13,214 results match your criteria Juvenile Rheumatoid Arthritis


The mortality rate and causes of death among juvenile idiopathic arthritis patients in Finland.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Children and Adolescents, Oulu University Hospital; Medical Research Centre, University of Oulu and Oulu University Hospital; and PEDEGO Research Unit, University of Oulu, Finland.

Objectives: To explore mortality rates and causes of death in juvenile idiopathic arthritis (JIA) patients in Finland compared with the general population.

Methods: All incident patients with JIA (age <16 years at the index day) during 2000-2014 were collected from the nationwide register maintained by the Social Insurance Institution of Finland and The National Population Registry identified three age-, sex- and residence-matched controls for each case. They were followed up together until 31st Dec 2015. Read More

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February 2019

Relative risk of tuberculosis in patients with rheumatic diseases managed with anti-tumour necrosis factor-alpha therapy: A nationwide cohort study.

J Clin Pharm Ther 2019 Feb 14. Epub 2019 Feb 14.

Turkish Medicines and Medical Devices Agency, Ministry of Health, Ankara, Turkey.

What Is Known And Objective: Anti-tumour necrosis factor-alpha (anti-TNF-α) therapy is known to raise the risk of granulomatous infections, leading to development of risk management strategies at national or global level. This study aimed to determine the relative risk (RR) of tuberculosis (TB) due to anti-TNF-α usage in patients with rheumatologic diseases (RDs) in a nationwide basis.

Method: This retrospective cohort study included patients with rheumatoid arthritis (RA), ankylosing spondylitis, juvenile idiopathic arthritis or psoriatic arthritis (PsA) that treated with or without anti-TNF-α agents, as registered in the national prescription information system between years 2013 and 2015. Read More

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http://dx.doi.org/10.1111/jcpt.12814DOI Listing
February 2019

Long-term outcomes in juvenile idiopathic arthritis: 18 years of follow-up in the population-based Nordic Juvenile Idiopathic Arthritis (JIA) cohort.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.

Objectives: This study assessed the long-term course, remission rate and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population-based setting from the early biologic era.

Methods: A total of 510 consecutive cases of JIA with disease onset between 1997 and 2000 from defined geographic regions in Denmark, Norway, Sweden and Finland were prospectively included in this 18-year cohort study. At the follow-up visit, patient-reported, demographic and clinical data were collected. Read More

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http://dx.doi.org/10.1002/acr.23853DOI Listing
February 2019

Fatigue and sleep in children and adolescents with juvenile idiopathic arthritis:a cross-sectional study

Turk J Med Sci 2019 Feb 11;49(1):58-65. Epub 2019 Feb 11.

Background/aim: The aims of this study were to primarily investigate fatigue and sleep and to secondarily examine possible relationships between disease activity, pain, and functional ability in children and adolescents with juvenile idiopathic arthritis (JIA).

Materials And Methods: Ninety-six patients were enrolled in the study. Disease activity, functional ability, fatigue symptoms, fatigue severity, and sleep quality were assessed with the Juvenile Arthritis Disease Activity Score (JADAS), Childhood Health Assessment Questionnaire (CHAQ), Pediatric Quality of Life Inventory-Multidimensional Fatigue Scale (PedsQL-F), visual analog scale (VAS), and Pittsburgh Sleep Quality Index (PSQI), respectively. Read More

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http://dx.doi.org/10.3906/sag-1711-167DOI Listing
February 2019

Participation in school sports among children and adolescents with juvenile idiopathic arthritis in the German National Paediatric Rheumatologic Database, 2000-2015: results from a prospective observational cohort study.

Pediatr Rheumatol Online J 2019 Feb 11;17(1). Epub 2019 Feb 11.

Epidemiology Unit, German Rheumatism Research Centre Berlin and Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Chariteplatz 1, 10117, Berlin, Germany.

Background: Regular school sports can help adolescents achieve the recommended amount of daily physical activity and provide knowledge, attitudes and behavioral skills that are needed in order to adopt and maintain a physically active lifestyle. Furthermore, it reaches all children including those that are at risk for engaging in more sedentary types of behavior. Since adolescents with juvenile idiopathic arthritis (JIA) are less involved in physical and social activities than their healthy peers, the objectives were to (1) estimate the prevalence of participation in school sports among patients with JIA; (2) determine the correlates associated with school sports absenteeism; and (3) investigate whether attendance in school sports has changed in the era of biologics. Read More

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http://dx.doi.org/10.1186/s12969-019-0306-9DOI Listing
February 2019

Children with Enthesitis Have Worse Quality of Life, Function, and Pain, Irrespective of their Juvenile Arthritis Category.

Arthritis Care Res (Hoboken) 2019 Feb 11. Epub 2019 Feb 11.

School of Public Health, University of Alberta.

Objective: To estimate the impact of enthesitis on patient-reported outcomes (PROs) in children with juvenile idiopathic arthritis (JIA), irrespective of JIA category.

Methods: Children in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were studied. Entheseal tenderness by physician examination in 33 defined locations, Juvenile Arthritis Quality of life Questionnaire (JAQQ), Quality of My Life questionnaire (QoML), Childhood Health Assessment Questionnaire (CHAQ), and a pain visual analogue scale (VAS) were completed at enrolment, every 6 months for 2 years, and then yearly up to 5 years. Read More

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http://dx.doi.org/10.1002/acr.23844DOI Listing
February 2019

Targeting Tregs in Juvenile Idiopathic Arthritis and Juvenile Dermatomyositis-Insights From Other Diseases.

Front Immunol 2019 25;10:46. Epub 2019 Jan 25.

Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, United Kingdom.

Regulatory T cells (Tregs) are believed to be dysfunctional in autoimmunity. Juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) result from a loss of normal immune regulation in specific tissues such as joints or muscle and skin, respectively. Here, we discuss recent findings in regard to Treg biology in oligo-/polyarticular JIA and JDM, as well as what we can learn about Treg-related disease mechanism, treatment and biomarkers in JIA/JDM from studies of other diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355674PMC
January 2019
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Juvenile Idiopathic Arthritis-Education, Knowledge, and Patient Outcomes.

Authors:
Yosef Uziel

J Pediatr 2019 Feb 5. Epub 2019 Feb 5.

Pediatric Rheumatology Unit, Department of Pediatrics, Meir Medical Center, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2019.01.027DOI Listing
February 2019

Evidence for M2 macrophage activation in patients with enthesitis-related arthritis category of juvenile idiopathic arthritis.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.

Recently, an increase in CD163 macrophages in ileal biopsies from ankylosing spondylitis patients and an increase in intermediate monocytes in enthesitis-related arthritis (ERA) have been reported. Thus, we studied sCD163 levels as M2 macrophage marker in serum and synovial fluid (SF) of ERA children and CD163 expression on monocyte subsets. Serum samples from ERA patients and healthy controls (HC) were assayed for sCD163 (ELISA). Read More

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http://dx.doi.org/10.1007/s10067-018-04408-xDOI Listing
February 2019
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Janus kinase 1/2 inhibition with baricitinib in the treatment of juvenile dermatomyositis.

Brain 2019 Feb 1. Epub 2019 Feb 1.

Infection, Inflammation and Rheumatology Section, UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1093/brain/awz005DOI Listing
February 2019
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The Association of Short-term Ultraviolet Radiation Exposure and Disease Severity in Juvenile Dermatomyositis.

Arthritis Care Res (Hoboken) 2019 Feb 4. Epub 2019 Feb 4.

University of California, San Francisco.

Objective: Ultraviolet radiation (UVR) is considered to be an important environmental factor in the clinical course of children with JDM. We aimed to evaluate the association between UVR and severe disease outcomes in JDM.

Methods: This is a cross-sectional study of JDM subjects enrolled in the U. Read More

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http://dx.doi.org/10.1002/acr.23840DOI Listing
February 2019
1 Read

Anterior atlantoaxial subluxation with Down syndrome and arthritis: case report.

J Spine Surg 2018 Dec;4(4):803-809

Nueva Granada Military University, Bogotá, Colombia.

Down syndrome (DS) occurs when an individual has a full or partial extra copy of chromosome 21 and is the most common of all malformation syndromes. Associating with numerous pathologies like anterior atlantoaxial subluxation (AAAS) which is an increase in the space between the anterior arch of the first cervical vertebra (C1) and the odontoid process of the second vertebra (C2), most of the time its asymptomatic, only 1-2% to all the 30% who may have the AAAS and DS develop clinical symptoms. In this occasion, we present the case of a patient with SD and Juvenile chronic arthritis (JCA) who has atlantoaxial subluxation of approximately 11mm, basilar impression and platybasia with severe medullary compression in 2 points, requiring surgical management by the Neurological Surgery Service in Bucaramanga-Colombia. Read More

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http://dx.doi.org/10.21037/jss.2018.12.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330583PMC
December 2018

Progressive pseudorheumatoid dysplasia: a report of three cases and a review of radiographic and magnetic resonance imaging findings.

Skeletal Radiol 2019 Feb 2. Epub 2019 Feb 2.

Department of Radiology, The Children's Hospital of Philadelphia, 34th Street & Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Progressive pseudorheumatoid dysplasia (PPD) is a rare disorder of postnatal skeletal and cartilage development that often presents with similar clinical findings to juvenile idiopathic arthritis. Patients with PPD display findings of progressive cartilage loss and secondary osteoarthritis over serial imaging studies and have an absence of elevation of inflammatory markers. Awareness of the imaging features of PPD on radiographs and magnetic resonance imaging (MRI) may be important for early diagnosis and surveillance of the disease. Read More

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http://dx.doi.org/10.1007/s00256-019-3165-zDOI Listing
February 2019
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Juvenile Idiopathic Arthritis: An Idea Whose Time Has Gone?

J Rheumatol 2019 Feb;46(2):124-126

Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.3899/jrheum.180922DOI Listing
February 2019

Spondyloarthritis Research Consortium of Canada Scoring System for Sacroiliitis in Juvenile Spondyloarthritis/Enthesitis-related Arthritis: A Reliability, Validity, and Responsiveness Study.

J Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

From the Joint Department of Medical Imaging, University Health Network, University of Toronto; Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto; Division of Pediatric Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario; Division of Pediatric Rheumatology, Department of Pediatrics, The University of Alberta, Edmonton, Alberta; Kanchi Kamakoti CHILDS Trust Hospital, Chennai; Department of Radiology, Christian Medical College, Vellore, India; Makassed Hospital, Jerusalem, Israel; Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada. J. Panwar, MD, FRCR, Joint Department of Medical Imaging, University Health Network, University of Toronto, and Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, and Department of Radiology, Christian Medical College; S.M. Tse, MD, Division of Pediatric Rheumatology, The Hospital for Sick Children, University of Toronto; L. Lim, MD, FRCPC, Division of Pediatric Rheumatology, Department of Pediatrics, The University of Alberta; M.A. Tolend, Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto; S. Radhakrishnan, MD, Kanchi Kamakoti CHILDS Trust Hospital; M. Salman, MD, Makassed Hospital; R. Moineddin, PhD, Department of Family and Community Medicine, University of Toronto; A.S. Doria, MD, PhD, MSc, Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto; J. Stimec, MD, Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto. Address correspondence to Dr. J. Panwar, Department of Diagnostic Imaging, 555 University Ave., Toronto, Ontario M5G 1X8, Canada; or Department of Radiology, Christian Medical College, Vellore-632004, India. E-mail: Accepted for publication September 12, 2018.

Objective: Intra- and interreader reliability, construct validity, and responsiveness of the Spondyloarthritis Research Consortium of Canada (SPARCC) magnetic resonance imaging (MRI) scoring system were investigated for scoring sacroiliitis in patients with juvenile spondyloarthritis (JSpA)/enthesitis-related arthritis (ERA) who have received biologic and/or nonbiologic treatment.

Methods: Ninety whole-body MRI examinations with dedicated oblique coronal planes of the sacroiliac joints in 46 patients were independently reviewed and scored by 2 pediatric musculoskeletal radiologists, blinded to clinical details, using the SPARCC system. Intra- and interreader reliability was assessed by intraclass correlation coefficients (ICC). Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180222
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http://dx.doi.org/10.3899/jrheum.180222DOI Listing
February 2019
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Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis.

Pediatr Radiol 2019 Feb 1. Epub 2019 Feb 1.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.

Background: Post-contrast synovial thickness measurement is necessary for scoring disease activity in juvenile idiopathic arthritis (JIA). However, the timing of post-contrast sequences varies widely among institutions. This variation in timing could influence thickness measurements. Read More

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http://dx.doi.org/10.1007/s00247-018-04332-xDOI Listing
February 2019
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Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration.

Front Immunol 2018 15;9:3167. Epub 2019 Jan 15.

Arthritis Research UK Centre for Adolescent Rheumatology at UCL, ULCH and GOSH, London, United Kingdom.

Type 1 interferons (IFN) are an antiviral cytokine family, important in juvenile onset systemic lupus erythematosus (jSLE) which is more common in females, around puberty. We report that plasmacytoid dendritic cells (pDC) from healthy females produced more type 1 IFN after toll like receptor (TLR) 7 signaling than males, even before puberty, but that puberty itself associated with increased production of type 1 IFN. A unique human model allows us to show that this was related to X chromosome number, and serum testosterone concentration, in a manner which differed depending on the number of X chromosomes present. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345344PMC
January 2019
1 Read

Surgical correction of dentofacial deformities in juvenile idiopathic arthritis: a systematic literature review.

Int J Oral Maxillofac Surg 2019 Jan 28. Epub 2019 Jan 28.

Department of Oral and Maxillofacial Surgery, Aarhus University Hospital and Section of Oral Surgery and Oral Pathology, Aarhus University, Aarhus, Denmark.

The aim of this study was to assess current evidence for the surgical correction of dentofacial deformities in patients with temporomandibular joint (TMJ) involvement from juvenile idiopathic arthritis (JIA). A systematic literature review, according to the PRISMA guidelines, was conducted. Meta-analyses, randomized controlled trials, cohort studies, observational studies, and case reports were eligible for inclusion. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.01.007DOI Listing
January 2019

An image-based kinematic model of the tibiotalar and subtalar joints and its application to gait analysis in children with Juvenile Idiopathic Arthritis.

J Biomech 2019 Jan 9. Epub 2019 Jan 9.

Department of Mechanical Engineering and INSIGNEO Institute for in silico Medicine, University of Sheffield, Sheffield, United Kingdom.

In vivo estimates of tibiotalar and the subtalar joint kinematics can unveil unique information about gait biomechanics, especially in the presence of musculoskeletal disorders affecting the foot and ankle complex. Previous literature investigated the ankle kinematics on ex vivo data sets, but little has been reported for natural walking, and even less for pathological and juvenile populations. This paper proposes an MRI-based morphological fitting methodology for the personalised definition of the tibiotalar and the subtalar joint axes during gait, and investigated its application to characterise the ankle kinematics in twenty patients affected by Juvenile Idiopathic Arthritis (JIA). Read More

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http://dx.doi.org/10.1016/j.jbiomech.2018.12.041DOI Listing
January 2019
2.751 Impact Factor

Juvenile case of multiple morphea profunda resulting in joint contracture that was successfully treated with cyclosporin A: A case report and review of the published works.

J Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Morphea profunda refers to inflammatory and sclerotic lesions that start primarily from the deep dermis, subcutaneous fat and fascia. Its pediatric case published work is limited. Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate. Read More

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http://dx.doi.org/10.1111/1346-8138.14801DOI Listing
January 2019
1 Read

Juvenile Sjögren's syndrome: clinical characteristics with focus on salivary gland ultrasonography.

Arthritis Care Res (Hoboken) 2019 Jan 30. Epub 2019 Jan 30.

Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Norway.

Background/objectives: Juvenile Sjögren's syndrome (jSS) is a rare, poorly defined and possibly underdiagnosed condition affecting children/adolescents. The aim of this study was to characterize symptoms and clinical findings of jSS, and to explore the clinical application of major salivary gland ultrasonography (SGUS) in patients with jSS.

Methods: A cross-sectional multicenter study recruited patients with disease onset until 18 years of age (n=67). Read More

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http://dx.doi.org/10.1002/acr.23839DOI Listing
January 2019
1 Read

A Case of Sporadic Blau Syndrome with an Uncommon Clinical Course.

Case Rep Rheumatol 2018 30;2018:6292308. Epub 2018 Dec 30.

Department of Pediatrics, National Hospital Organization Higashi-Saga Hospital, 7324 Harakoga, Miyaki-machi, Saga 849-0101, Japan.

Background: Sporadic Blau syndrome (SBS), a rare systemic inflammatory disease in children, is associated with gene mutations. SBS is often misdiagnosed as juvenile idiopathic arthritis (JIA) because of their similar clinical manifestations. Herein, we present a case of SBS with an uncommon clinical course. Read More

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http://dx.doi.org/10.1155/2018/6292308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332973PMC
December 2018

Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis.

Front Immunol 2018 14;9:3168. Epub 2019 Jan 14.

Division of Pediatric Rheumatology, Department of Pediatrics, and the Center for Immunology, University of Minnesota, Minneapolis, MN, United States.

Autoantibody production occurs in juvenile idiopathic arthritis (JIA) and numerous other autoimmune diseases. In some conditions, the autoantibodies are clearly pathogenic, whereas in others the roles are less defined. Here we review various autoantibodies associated with JIA, with a particular focus on antinuclear antibodies and antibodies recognizing citrullinated self-antigens. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03168
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http://dx.doi.org/10.3389/fimmu.2018.03168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339949PMC
January 2019
2 Reads

Interleukin-6 in juvenile idiopathic arthritis.

Authors:
Shinji Akioka

Mod Rheumatol 2019 Jan 28:1-30. Epub 2019 Jan 28.

a Department of Pediatrics , Kyoto Prefectural University of Medicine , Kyoto Japan.

Juvenile idiopathic arthritis (JIA) is a chronic childhood arthritis. Its pathogenesis is very complicated, with the involvement of not only immune cells but various types of parenchymal cells, and is affected by both genetic and environmental predispositions. The clinical spectrum from inflammation to related conditions is largely mediated by cytokines including interleukin (IL)-6. Read More

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http://dx.doi.org/10.1080/14397595.2019.1574697DOI Listing
January 2019

A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases.

J Immunol 2019 Jan 25. Epub 2019 Jan 25.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229; and

CD163 facilitates regulation and resolution of inflammation and removal of free hemoglobin and is highly expressed in myeloid cells from patients with inflammatory disorders, such as systemic juvenile idiopathic arthritis (SJIA) and macrophage activation syndrome (MAS). Our recent studies indicate that regulation of CD163 mRNA expression is a key functional property of polarized monocytes and macrophages and is mediated at the transcriptional and posttranscriptional level, including via microRNAs. The goal of the current study is to develop a multiparameter flow cytometry panel incorporating detection of CD163 mRNA for polarized monocyte and macrophage populations in disorders such as SJIA and MAS. Read More

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http://dx.doi.org/10.4049/jimmunol.1800765DOI Listing
January 2019
1 Read

Hypertrophic cervical spine pachymeningitis due to sarcoidosis: a case report.

Hosp Pract (1995) 2019 Feb 6:1-5. Epub 2019 Feb 6.

d Pathology , Lehigh Valley Health Network , Allentown , PA , USA.

Hypertrophic pachymeningitis (HP) is a chronic, progressive diffuse inflammatory condition that leads to thickening of the dura mater and can be idiopathic or associated with sarcoidosis among other disorders. In this case report, we present a rare case of cervical spine HP in a 29-year-old woman in the post-partum period, who had a history of pituitary adenoma and juvenile rheumatoid arthritis. Magnetic resonance imaging (MRI) of the spine revealed a soft tissue mass and moderate cord compression. Read More

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https://www.tandfonline.com/doi/full/10.1080/21548331.2019.1
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http://dx.doi.org/10.1080/21548331.2019.1575645DOI Listing
February 2019
7 Reads

The American College of Rheumatology Provisional criteria for clinically relevant improvement in children & adolescents with childhood-onset systemic lupus erythematosus.

Arthritis Care Res (Hoboken) 2019 Jan 25. Epub 2019 Jan 25.

Department of Environmental Health Sciences, University of Cincinnati, Cincinnati, OH.

Objectives: To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with focus on clinically relevant improvement (CRI ).

Methods: Pediatric nephrology and rheumatology subspecialists (n=213) experienced in cSLE management were invited to define CRI and rate a total of 433 unique patient-profiles for the presence/absence of CRI . Patient-profiles included the cSLE core response variables [cSLE-CRVs: global assessment of patient well-being (Patient-global), physician assessment of cSLE activity (MD-global), disease activity index score (here: Systemic Lupus Erythematosus Disease Activity Index), urine protein-to-creatinine ratio (UPCR), Child Health Questionnaire physical summary score (CHQ-PhS)]. Read More

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http://dx.doi.org/10.1002/acr.23834DOI Listing
January 2019
1 Read

The association of CAT-262C/T polymorphism with catalase activity and treatment response in juvenile idiopathic arthritis.

Rheumatol Int 2019 Mar 24;39(3):551-559. Epub 2019 Jan 24.

Faculty of Medicine, Department of Biochemistry, University of Niš, Bulevar dr Zorana Djindjića 81, Niš, 18000, Serbia.

Oxidative stress is believed to be of great importance for both the etiology and the persistence of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate the association of -262C/T polymorphism of the catalase (CAT) gene with JIA, as well as to evaluate whether this polymorphism can influence plasma CAT activity and outcome in JIA patients treated with etanercept. A total of 154 subjects (60 JIA patients and 94 healthy volunteers) were screened for CAT-262C/T gene polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Read More

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http://dx.doi.org/10.1007/s00296-019-04246-3DOI Listing
March 2019
4 Reads

Pediatrician Beliefs about Juvenile Idiopathic Arthritis May Result in Referral Delays: A Spanish National Survey.

J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Pediatric Rheumatology Unit, University Hospital 12 de Octubre, Madrid, Spain; Department of Public Health and Maternal and Pediatric Health, Complutense University of Madrid, Madrid, Spain. Electronic address:

We explored, through a national survey, pediatrician beliefs and misconceptions that could interfere with early referral of patients with juvenile idiopathic arthritis. A total of 831 pediatricians participated. Approximately one-half of the respondents underestimated the incidence of the disease and thought that pain was the leading symptom of oligoarticular forms. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.038DOI Listing
January 2019
1 Read

Drug Retention Rate and Predictive Factors of Drug Survival for Interleukin-1 Inhibitors in Systemic Juvenile Idiopathic Arthritis.

Front Pharmacol 2018 8;9:1526. Epub 2019 Jan 8.

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Few studies have reported the drug retention rate (DRR) of biologic drugs in juvenile idiopathic arthritis (JIA), and none of them has specifically investigated the DRR of interleukin (IL)-1 inhibitors on systemic JIA (sJIA). This study aims to describe IL-1 inhibitors DRR and evaluate predictive factors of drug survival based on data from a real-world setting concerning sJIA. Medical records from sJIA patients treated with anakinra (ANA) and canakinumab (CAN) were retrospectively analyzed from 15 Italian tertiary referral centers. Read More

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http://dx.doi.org/10.3389/fphar.2018.01526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331484PMC
January 2019

JIA and the Gut Microbiome: More Clues, More Questions.

Authors:
Daniel B Horton

Arthritis Rheumatol 2019 Jan 22. Epub 2019 Jan 22.

Division of Pediatric Rheumatology, Rutgers Robert Wood Johnson Medical School.

When we diagnose children with juvenile idiopathic arthritis, JIA's middle name serves as a reminder of our ignorance of its origins. Even the largest, most comprehensive genomic studies on JIA performed to date have explained only a minority of disease heritability. Families rightfully ask why their children have developed this condition, and many of us perform our own version of the "genetics and environment" hand-waving show, often (at least for this clinician) to an unsatisfied audience. Read More

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http://dx.doi.org/10.1002/art.40842DOI Listing
January 2019

Temporomandibular joint damage in juvenile idiopathic arthritis: Diagnostic validity of diagnostic criteria for temporomandibular disorders.

J Oral Rehabil 2019 Jan 21. Epub 2019 Jan 21.

School of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples "Federico II", Naples, Italy.

Background: Diagnostic criteria reported in the expanded taxonomy for temporomandibular disorders include a standardised clinical examination and diagnosis (DC/TMD 3.B) of temporomandibular joint (TMJ) damage in patients with juvenile idiopathic arthritis (JIA); however, their validity is unknown.

Objectives: To assess the validity of DC/TMD 3. Read More

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http://dx.doi.org/10.1111/joor.12769DOI Listing
January 2019
2 Reads

Discontinuing TNF-inhibitors before gestational week 20 in well-controlled rheumatoid arthritis and juvenile arthritis is not associated with a disease worsening in late pregnancy.

Arthritis Rheumatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics and Family Medicine and Public Health, University of California San Diego, San Diego, California, USA.

Objective: To investigate whether the discontinuation of tumor necrosis factor inhibitors (TNFi) during pregnancy is associated with any changes of the disease course in women with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).

Methods: Pregnant women from the U.S. Read More

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http://doi.wiley.com/10.1002/art.40821
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http://dx.doi.org/10.1002/art.40821DOI Listing
January 2019
4 Reads

Systemic calprotectin and chronic inflammatory rheumatic diseases.

Joint Bone Spine 2019 Jan 17. Epub 2019 Jan 17.

GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France; Sinnovial SAS, Avenue de Kimberley, 38130 Échirolles, France.

Calprotectin is a calcium binding protein produced by neutrophils and monocytes locally at the site of inflammation in order to trigger the innate immunity receptors. This unique characteristic makes it a good proxy for evaluation of local inflammation in chronic inflammatory rheumatic diseases. Complete data suggest, in inflammatory rheumatic diseases, a relevant role of calprotectin in the inflammatory process. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183034
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http://dx.doi.org/10.1016/j.jbspin.2019.01.003DOI Listing
January 2019
9 Reads

The effects of TNF-alpha inhibitor therapy on the incidence of infection in JIA children: a meta-analysis.

Pediatr Rheumatol Online J 2019 Jan 18;17(1). Epub 2019 Jan 18.

Department of Paediatrics, Medical School, University of Pécs, 7. József Attila street, Pécs, 7623, Hungary.

Background: Juvenile Idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The diagnosis is based on the underlying symptoms of arthritis with an exclusion of other diseases Biologic agents are increasingly used on the side of disease-modifying anti-rheumatic drugs (DMARD) in JIA treatment.

Main Body: The aim of this meta-analysis was to investigate the observed infections in JIA children during tumor necrosis factor (TNF)-alpha inhibitor therapy. Read More

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http://dx.doi.org/10.1186/s12969-019-0305-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339290PMC
January 2019
2 Reads

Association of hand grip strength with disease activity, disability and quality of life in children and adolescents with Juvenile Idiopathic Arthritis.

Adv Rheumatol 2018 Jun 28;58(1):11. Epub 2018 Jun 28.

Rheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Juvenile idiopathic arthritis (JIA) affects wrist and hand joints leading to decrease hand function and patients' daily living activities. The assessment of hand grip strength (HGS) in children and adolescents with JIA is of major importance, and the association of HGS with JIA disease activity, disability and quality of life has not been explored. The primary objective of this study was to evaluate hand grip strength (HGS) in children and adolescents with Juvenile Idiopathic Arthritis (JIA) compared to matched healthy peers. Read More

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https://advancesinrheumatology.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s42358-018-0012-1DOI Listing
June 2018
6 Reads

Heel pain in a young patient: Calcaneal involvement in juvenile spondyloarthritis.

Arthritis Rheumatol 2019 Jan 17. Epub 2019 Jan 17.

Lariboisière Hospital, Paris, France.

An 11-year-old boy presented with left heel pain and mild fever. He recently experienced diffuse arthralgias (right knee, costochondral junctions and both ankles). Biologic tests were normal except for a slightly increased erythrocyte sedimentation rate. Read More

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http://dx.doi.org/10.1002/art.40839DOI Listing
January 2019
1 Read

The long and winding road in pharmaceutical development of canakinumab from rare genetic autoinflammatory syndromes to myocardial infarction and cancer.

Authors:
Hermann Gram

Pharmacol Res 2019 Jan 14. Epub 2019 Jan 14.

Novartis Institutes for BioMedical Research, Forum 1, CH-4002 Basel, Switzerland. Electronic address:

Interleukin-1beta (IL-1β) is an ancient and evolutionary conserved cytokine, which orchestrates innate immune responses triggered by infections in vertebrates. While temporally limited induction of IL-1β protects the organism against traumatic or infectious insults, its chronic production in unabated inflammation causes or enhances clinical manifestations of disease in almost all organ systems. Therefore, pharmacological targeting of IL-1β in a variety of clinical inflammatory conditions may provide symptomatic relief or profound disease modification. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.023DOI Listing
January 2019
1 Read

Self-Healing Juvenile Cutaneous Mucinosis: A Case Report in the Middle East.

Am J Case Rep 2019 Jan 16;20:65-69. Epub 2019 Jan 16.

Department of Pediatrics and Adolescent Medicine, Lebanese American University Medical Center, Beirut, Lebanon.

BACKGROUND Self-healing juvenile cutaneous mucinosis (SHJCM) is a rarely diagnosed disease worldwide, with less than 20 reported cases in the literature. It is characterized by a rather benign course in juvenile patients with nodular and mucinous skin eruption and edema. CASE REPORT A 12-year-old male patient previously healthy presented to the pediatrics clinic with a 1-week history of bilateral palmer pruritus and plantar tenderness upon walking, preceded by eruption of erythematous patch on his neck. Read More

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https://www.amjcaserep.com/abstract/index/idArt/910047
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http://dx.doi.org/10.12659/AJCR.910047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345112PMC
January 2019
2 Reads

Predictors of Effectiveness of Anakinra in Systemic Juvenile Idiopathic Arthritis.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the Università degli Studi di Genova, and the Istituto Giannina Gaslini, Genoa; Fondazione Institute for Research and Health Care (IRCCS) Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Instituto de Criança - Faculty of Medicine of the University of São Paulo (FMUSP), São Paulo, Brazil. MG has received speaking or consultant fees from Sobi. B. Saccomanno, MD, Research Fellow, Università degli Studi di Genova; J. Tibaldi, MD, PhD Student, Università degli Studi di Genova; F. Minoia, MD, Dirigente Medico, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico; F. Bagnasco, PhD, Biostatistician, Istituto Giannina Gaslini; A. Pistorio, MD, PhD, Dirigente Medico, Istituto Giannina Gaslini; A. Guariento, MD, Research Fellow, Istituto Giannina Gaslini, and Instituto de Criança - FMUSP; R. Caorsi, MD, Dirigente Medico, Istituto Giannina Gaslini; A. Consolaro, MD, PhD, Assistant Professor, Università degli Studi di Genova and Istituto Giannina Gaslini; M. Gattorno, MD, Dirigente Medico, Istituto Giannina Gaslini; A. Ravelli, MD, Professor of Pediatrics, Università degli Studi di Genova and Istituto Giannina Gaslini. Dr. Saccomanno and Dr. Tibaldi contributed equally to the study. Address correspondence to Dr. A. Ravelli, Clinica Pediatrica e Reumatologia, Istituto G. Gaslini, Via G. Gaslini 5, 16147 Genoa, Italy. E-mail: Accepted for publication September 20, 2018.

Objective: To seek predictors of therapeutic response to the interleukin (IL)-1 inhibitor anakinra in children with systemic-onset juvenile idiopathic arthritis (sJIA).

Methods: The clinical charts of all patients with sJIA who were newly treated with anakinra at our center between 2004 and 2017 were reviewed retrospectively. Predictors included baseline demographic, clinical, and laboratory variables as well as previous or concomitant therapies. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180331
Publisher Site
http://dx.doi.org/10.3899/jrheum.180331DOI Listing
January 2019
8 Reads

Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the Department of Dentistry and Oral Health, Aarhus University; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital; Department of Orthodontics, Aarhus University; Department of Pediatrics, Aarhus University Hospital; Pediatric Rheumatology Clinic, Pediatrics and Adolescent Medicine, Aarhus University Hospital; Section of Oral Surgery and Oral Pathology, Aarhus University, Aarhus, Denmark; Harvard School of Dental Medicine and Harvard Medical School; Department of Plastic and Oral Surgery, Boston Children's Hospital; Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, Massachusetts; Oral and Maxillofacial Surgery and Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia; University of Alabama at Birmingham, Birmingham, Alabama; Perelman School of Medicine, University of Pennsylvania; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Seattle Children's Hospital, Seattle, Washington, USA; Department of Neuroscience, Reproductive Sciences and Oral Sciences, Section of Orthodontics, University of Naples Federica II, Naples; Dental School, Section of Paediatric Dentistry, University of Turin, Turin, Italy; Department of Orthodontics and Pediatric Dentistry, UZB, University Center for Dental Medicine, Basel; Department of Diagnostic Imaging, University Children's Hospital Zurich, Switzerland; Department of Pediatrics, University of North Norway and Department of Clinical Medicine, UiT the Arctic University of Norway, Tromso; Section of Orthodontics, Department of Maxillofacial Radiology, Institute of Clinical Dentistry, University of Oslo, Oslo; Department of Otorhinolaryngology, Division of Oral and Maxillofacial Surgery, University Hospital North Norway; The Public Dental Service Competence Centre of North Norway; Department of Clinical Medicine, Faculty of Health Sciences, The Arctic University of Norway, Tromso, Norway; Department of Orthodontics, Faculty of Dentistry, Rigas Stradins University, Riga, Latvia; Department of Pediatrics, Division of Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario; Department of Pediatrics, Cumming School of Medicine, University of Calgary; Alberta Children's Hospital, Calgary, Alberta, Canada; Malmo University, Faculty of Odontology, Orofacial Pain Unit, Malmo and Skane University Hospital, Specialized Pain Rehabilitation, Lund, Sweden; Department of Ear and Oral Diseases, Tampere University Hospital; Faculty of Medicine and Life Sciences, University of Tampere; Institute of Dentistry and University of Eastern Finland, Kuopio, Finland. P. Stoustrup, Associate Professor, Section of Orthodontics, Department of Dentistry and Oral Health, Aarhus University; C.M. Resnick, Assistant Professor, Oral and Maxillofacial Surgery, Harvard School of Dental Medicine and Harvard Medical School, and Department of Plastic and Oral Surgery, Boston Children's Hospital; T.K. Pedersen, PhD, Consultant Orthodontist, Professor, Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Section of Orthodontics, Aarhus University; S. Abramowicz, DMD, MPH, FACS, Associate Professor, Oral and Maxillofacial Surgery and Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta; A. Michelotti, DDS, Orthodontist, Department of Neuroscience, Reproductive Sciences and Oral Sciences, Section of Orthodontics, University of Naples Federica II; A. Küseler, DDS, PhD, Department of Orthodontics, Aarhus University Hospital; C. Verna, DDS, PhD, Professor, Head, Department of Orthodontics and Pediatric Dentistry, UZB, University Center for Dental Medicine; C.J. Kellenberger, MD, Prof., Dr. med., Department of Diagnostic Imaging, University Children's Hospital Zurich; E. Berit Nordal, MD, PhD, Department of Pediatrics, University of North Norway, and Department of Clinical Medicine, UiT the Arctic University of Norway; G. Caserta, DDS, Lecturer, CIR - Dental School, Section of Paediatric Dentistry, University of Turin; I. Jankovska, DDS, PhD, Assistant Professor, Department of Orthodontics, Faculty of Dentistry, Rigas Stradins University; J.M. Halbig, Dr. med. Dent., DDS, The Public Dental Service Competence Centre of North Norway; K.D. Kristensen, DDS, PhD, Guest Researcher, Section of Orthodontics, Department of Dentistry and Oral Health, Aarhus University; L.Z. Arvidsson, DDS, PhD, Associate Professor, Department of Maxillofacial Radiology, Institute of Clinical Dentistry, University of Oslo; L. Spiegel, MD, FRCPC, Department of Pediatrics, Division of Rheumatology, The Hospital for Sick Children, University of Toronto; M.L. Stoll, MD, PhD, MSCS, University of Alabama at Birmingham; M. Lerman, MD, MSc, PhD, Assistant Professor of Clinical Pediatrics, Perelman School of Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia; M. Glerup, MD, Department of Pediatrics, Aarhus University Hospital; P. Defabianis, MD, DDS, Associate Professor, Chairman and Program Director of Pediatric Dentistry, Section of Pediatric Dentistry, CIR-Dental School, University of Turin; P. Frid, DDS, Department of Otorhino - laryngology, Division of Oral and Maxillofacial Surgery, University Hospital North Norway, and Public Dental Service Competence Centre of North Norway, and Department of Clinical Medicine, Faculty of Health Sciences, The Arctic University of Norway; P. Alstergren, DDS, PhD, Malmo University, Faculty of Odontology, Orofacial Pain Unit, and Skane University Hospital, Specialized Pain Rehabilitation; R.Q. Cron, MD, PhD, University of Alabama at Birmingham; S. Ringold, MD, MS, Seattle Children's Hospital; S.E. Nørholt, DDS, PhD, Clinical Professor, Consultant Surgeon, Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, and Section of Oral Surgery and Oral Pathology, Aarhus University; T. Peltomäki, DDS, PhD, Department of Ear and Oral Diseases, Tampere University Hospital, and Faculty of Medicine and Life Sciences, University of Tampere, and Institute of Dentistry and University of Eastern Finland; T. Herlin, MD, DMSci, Pediatric Rheumatology Clinic, Pediatrics and Adolescent Medicine, Aarhus University Hospital; Z.S. Peacock, DMD, MD, Assistant Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, and Harvard School of Dental Medicine; M. Twilt, MD, MSCE, PhD, Assistant Professor, Department of Pediatrics, Cumming School of Medicine, University of Calgary, and Alberta Children's Hospital. Address correspondence to Dr. P. Stoustrup, Section of Orthodontics, Department of Dentistry and Oral Health, Aarhus University, Vennelyst Boulevard 9-11, 8000 Aarhus C, Denmark. E-mail: Accepted for publication September 24, 2018.

Objective: To propose multidisciplinary, consensus-based, standardization of operational terminology and method of assessment for temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA).

Methods: Using a sequential expert group-defined terminology and methods-of-assessment approach by (1) establishment of task force, (2) item generation, (3) working group consensus, (4) external expert content validity testing, and (5) multidisciplinary group of experts final Delphi survey consensus.

Results: Seven standardized operational terms were defined: TMJ arthritis, TMJ involvement, TMJ arthritis management, dentofacial deformity, TMJ deformity, TMJ symptoms, and TMJ dysfunction. Read More

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http://dx.doi.org/10.3899/jrheum.180785DOI Listing
January 2019
1 Read

Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the British Columbia Children's Hospital and the University of British Columbia, Vancouver; Simon Fraser University, Burnaby, British Columbia; London Health Sciences Centre and Western University, London; Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario; IWK Health Centre and Dalhousie University, Halifax, Nova Scotia; Winnipeg Children's Hospital and University of Manitoba, Winnipeg, Manitoba; Hospital for Sick Children and University of Toronto, Toronto, Ontario; McGill University Health Centre and McGill University, Montreal, Quebec; Janeway Children's Health and Rehabilitation Centre and Memorial University, Saint John's, Newfoundland and Labrador; Royal University Hospital and University of Saskatchewan, Saskatoon, Saskatchewan; Centre Hospitalier Universitaire Sainte-Justine and Université de Montréal, Montreal; Centre Hospitalier Universitaire de Sherbrooke and Université de Sherbrooke, Sherbrooke, Quebec; Alberta Children's Hospital and University of Calgary, Alberta, Canada; Shands Children's Hospital and University of Florida, Gainesville, Florida, USA. The Research in Arthritis in Canadian Children Emphasizing Outcomes cohort was funded by a New Emerging Team research grant from the Canadian Institutes of Health Research (funding reference QNT 69301). Dr. Guzman was funded by a Clinical Investigator Award from the BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. J. Guzman, MD, MSc, Department of Pediatrics, University of British Columbia; A. Henrey, PhD, Department of Statistics and Actuarial Sciences, Simon Fraser University; T. Loughin, PhD, Department of Statistics and Actuarial Sciences, Simon Fraser University; R.A. Berard, MD, MSc, Department of Pediatrics, Western University; N.J. Shiff, MD, MHSc, Department of Pediatrics, University of Florida; R. Jurencak, MD, Department of Pediatrics, University of Ottawa; A.M. Huber, MD, MSc, Department of Pediatrics, Dalhousie University; K. Oen, MD, Department of Pediatrics and Child Health, University of Manitoba; K. Gerhold, MD, Department of Pediatrics and Child Health, University of Manitoba; B.M. Feldman, MD, MSc, Department of Pediatrics and Dalla Lana School of Public Health, University of Toronto; R. Scuccimarri, MD, Research Institute of the McGill University Health Centre; K. Houghton, MD, MSc, Department of Pediatrics, University of British Columbia; G. Chédeville, MD, Research Institute of the McGill University Health Centre; K. Morishita, MD, MHSc, Department of Pediatrics, University of British Columbia; B. Lang, MD, Department of Pediatrics, Dalhousie University; P. Dancey, MD, Department of Pediatrics, Memorial University; A.M. Rosenberg, MD, Department of Pediatrics, University of Saskatchewan; J. Barsalou, MD, MSc, Centre Hospitalier Universitaire Sainte-Justine and Université de Montréal; A. Bruns, MD, MSc, Centre Hospitalier Universitaire de Sherbrooke and Université de Sherbrooke; K. Watanabe Duffy, MD, Department of Pediatrics, University of Ottawa; S. Benseler, MD, PhD, Department of Pediatrics, University of Calgary; C.M. Duffy, MB, MSc, Department of Pediatrics, University of Ottawa; L.B. Tucker, MD, Department of Pediatrics, University of British Columbia. Address correspondence to Dr. J. Guzman, Division of Pediatric Rheumatology, BC Children's Hospital, 4500 Oak St., Suite K4-122, Vancouver, British Columbia V6H 3N1, Canada. E-mail: Accepted for publication September 13, 2018.

Objective: To estimate the probability of early remission with conventional treatment for each child with juvenile idiopathic arthritis (JIA). Children with a low chance of remission may be candidates for initial treatment with biologics or triple disease-modifying antirheumatic drugs (DMARD).

Methods: We used data from 1074 subjects in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180456
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http://dx.doi.org/10.3899/jrheum.180456DOI Listing
January 2019
6 Reads

The role of extracellular histones in systemic-onset juvenile idiopathic arthritis.

Ital J Pediatr 2019 Jan 14;45(1):14. Epub 2019 Jan 14.

Department of Rheumatology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, 200127, China.

Background: To explore the effects of extracellular histones released by activated neutrophils on systemic-onset juvenile idiopathic arthritis (SoJIA), and to study the change of serum histone level between the active and remissive stage of SoJIA, then to clarify the role of serum histone in the pathogenesis of SoJIA.

Methods: Twenty-six patients with SoJIA were recruited, and clinical informations were collected, and the serum histone was detected by ELISA. While neutrophils from normal children were incubated with the serum from the patients with SoJIA, also including incubated with FeCL3 and histone, the extracellular histone was detected, respectively; heparin was added to the above-mentioned groups to observe the changes of extracellular histone levels. Read More

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http://dx.doi.org/10.1186/s13052-019-0605-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332604PMC
January 2019
1 Read

SLICC classification criteria for juvenile systemic lupus erythematosus: a cross sectional study.

Acta Reumatol Port 2018 Oct-Dec;43(4):279-283

Universidade Federal de São Paulo.

Objectives: to verify the sensitivity and specificity of the criteria for systemic lupus erythematosus, proposed by the Systemic Lupus International Collaborating Clinics (SLICC) and compare it to the ACR lupus criteria, in a pediatric population.

Patients And Methods: this is an observational cohort study, with a descriptive analysis of data from a Pediatric Rheumatology center, including 23 patients with Juvenile Systemic Lupus Erythematosus (jSLE) and a control group of 24 patients with Juvenile Idiopathic Arthritis (JIA), both groups recently diagnosed and virgin of treatment. Information on signs and symptoms was obtained on the diagnostic consult, and the ACR and SLICC criteria were applied to both groups. Read More

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January 2019
3 Reads

Gut microbiota in children and altered profiles in juvenile idiopathic arthritis.

J Autoimmun 2019 Jan 9. Epub 2019 Jan 9.

Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence, Viale G. Pieraccini 24, 50139, Florence, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health, Meyer Children's Hospital, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy. Electronic address:

Microbial diversity plays a key role in the maintenance of intestinal homeostasis and in the development of the immune system in the gut mucosa. Maybe one of the most important function of our gut microbiota is the immune system education, in particular the discrimination of friends from foes that occurs during childhood. In addition to bacterial antigens, several metabolites of microbial origin have a crucial role in training of the immune system, such as Short Chain Fatty Acids (SCFAs). Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.001DOI Listing
January 2019
8.410 Impact Factor

Psoriatic fasciitis in a pediatric patient: A case report.

World J Clin Cases 2019 Jan;7(1):69-72

Department of Pediatric Rheumatology, Pamukkale University School of Medicine, Denizli 20070, Turkey.

Background: Diffuse fasciitis with psoriatic arthritis on magnetic resonance imaging (MRI) has not been previously described in childhood. Here we present the first case report of a pediatric patient developing fasciitis, beyond plantar fasciitis, with psoriatic arthritis.

Case Summary: An 11-year-old female was admitted with the complaints of psoriatic rash on the body associated with severe pain in the lower extremities and arthritis in the right knee. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i1.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327131PMC
January 2019
2 Reads

'Reluctant to assess pain': A qualitative study of healthcare professionals' beliefs about the role of pain in Juvenile Idiopathic Arthritis.

Arthritis Care Res (Hoboken) 2019 Jan 10. Epub 2019 Jan 10.

Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester.

Objective: Reducing pain is one of the main health priorities for children and young people with Juvenile Idiopathic Arthritis (JIA), however some studies indicate that pain is not routinely assessed in this patient group. The aim of this study was to explore healthcare professionals' (HCPs') beliefs about the role of pain and the prioritisation of its assessment in children and young people with JIA.

Methods: Semi-structured interviews were conducted with HCPs who manage children and young people (CYP) with JIA in the UK (including consultant and trainee paediatric rheumatologists, nurses, physiotherapists and occupational therapists). Read More

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http://dx.doi.org/10.1002/acr.23827DOI Listing
January 2019
2 Reads
4.713 Impact Factor

Prevalence and course of lower limb disease activity and walking disability over the first 5 years of juvenile idiopathic arthritis: results from the childhood arthritis prospective study.

Rheumatol Adv Pract 2018 24;2(2):rky039. Epub 2018 Nov 24.

School of Health & Life Sciences, Glasgow Caledonian University, Glasgow.

Objective: The aim was to investigate the time course of lower limb disease activity and walking disability in children with JIA over a 5-year course.

Methods: The Childhood Arthritis Prospective Study is a longitudinal study of children with a new JIA diagnosis. Childhood Arthritis Prospective Study data include demographics and core outcome variables at baseline, 6 months and yearly thereafter. Read More

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http://dx.doi.org/10.1093/rap/rky039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312095PMC
November 2018
1 Read