14,003 results match your criteria Juvenile Rheumatoid Arthritis


The iCanCope pain self-management application for adolescents with juvenile idiopathic arthritis: a pilot randomized controlled trial.

Rheumatology (Oxford) 2020 Jul 2. Epub 2020 Jul 2.

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario.

Objectives: To evaluate the feasibility and preliminary effectiveness of iCanCope with Pain (iCanCope), a smartphone-based pain self-management program, in adolescents with JIA. iCanCope featured symptom tracking, goal-setting, pain coping skills and social support.

Methods: A two-arm pilot randomized controlled trial was used to evaluate the iCanCope app compared with a version with symptom tracking only. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa178DOI Listing

Is it Kawasaki shock syndrome, Kawasaki-like disease or pediatric inflammatory multisystem disease? The importance of semantic in the era of COVID-19 pandemic.

RMD Open 2020 Jun;6(2)

Department of Clinical Sciences and Community Health, University of Milan, and ASST G. Pini, Milan, Italy.

A few weeks after the peak of the global 2019 novel coronavirus disease pandemic, cases of shock, multisystem inflammation and severe myocarditis have occurred in children and adolescents, generating some concerns and above all many questions. An almost immediate association raised with shock syndrome related to Kawasaki disease (KD). However, in light of bo/th experience and literature have taught us about severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection, and what already known on the epidemiology of KD, we suggest here the hypothesis of a new 'post-viral' systemic inflammatory disease related to excessive adaptive immune response rather than a form of KD caused by SARS-COV-2. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001333DOI Listing

Characterising pain flares in adolescent inflammatory and non-inflammatory musculoskeletal disorders: A qualitative study using an interpretative phenomenological approach.

Eur J Pain 2020 Jul 1. Epub 2020 Jul 1.

Centre for Epidemiology Versus Arthritis, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Adolescents with musculoskeletal disorders experience acute exacerbations in pain, colloquially called 'pain flares' in adult literature. This study aimed to explore adolescents' lived experience of pain flares, including what pain flares are, why they occur, how they are managed and what lasting effects they have on adolescents.

Methods: A sample of 10 adolescents diagnosed with juvenile idiopathic arthritis or chronic idiopathic pain syndrome were recruited from a tertiary hospital in the UK. Read More

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http://dx.doi.org/10.1002/ejp.1626DOI Listing

[Survival of bDMARDs in bionaive patients with rheumatoid arthritis: data from a retrospective 12-month follow-up].

Ter Arkh 2020 Jun 5;92(5):39-45. Epub 2020 Jun 5.

Nasonova Research Institute of Rheumatology.

Aim: Analysis of survival on biological therapy in previously bionaive patients with rheumatoid arthritis (RA) during the first year of therapy in real clinical practice.

Materials And Methods: The retrospective study included 204 adult patients with RA. In the hospital, patients were first prescribed therapy with various biological disease-modifying antirheumatic drugs (bDMARDs): infliximab, adalimumab, etanercept, certolizumab pegol, tocilizumab, abatacept (ABA), rituximab (RTM). Read More

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http://dx.doi.org/10.26442/00403660.2020.05.000630DOI Listing

[Sjögren's syndrome with juvenile onset].

Ter Arkh 2019 May 15;91(5):54-60. Epub 2019 May 15.

V.A. Nasonova Scientific and Research Institute of Rheumatology, Pediatric Department.

Aim to analyze demographic data, clinical features and results of laboratory and instrumental examinations in children with primary and secondary Sjögren syndrome (SS).

Materials And Methods: The study included all consequently patients, who hospitalized to the pediatric department of V.A. Read More

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http://dx.doi.org/10.26442/00403660.2019.05.000189DOI Listing

Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate.

Int J Pharm 2020 Jun 25;586:119580. Epub 2020 Jun 25.

School of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom. Electronic address:

Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) and it is mainly administered either orally or by subcutaneous (SC) injection, which are not so satisfactory. While orally administered MTX is associated with variable bioavailability and causes gastrointestinal side effects, including nausea and vomiting, SC injection is painful and produces high peak blood levels of MTX. Transdermal delivery presents an attractive alternative administration route. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119580DOI Listing

Successful Rituximab Monotherapy in Advanced-stage, Epstein-Barr Virus-positive Diffuse Large B-Cell Lymphoma in an Adolescent With Systemic Juvenile Idiopathic Arthritis.

J Pediatr Hematol Oncol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pediatrics, Division of Pediatric Hematology/Oncology.

Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV+ DLBCL) in pediatrics most commonly occurs as an iatrogenic immunodeficiency-associated lymphoproliferative disease. We report an 18-year-old female individual with refractory systemic juvenile idiopathic arthritis, treated with multiple immunosuppressive agents, who was diagnosed with stage III, EBV+ DLBCL. The patient achieved sustained complete remission after 4 weekly doses of rituximab monotherapy and reduction of immunosuppression. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001869DOI Listing

Prevalence, incidence and epidemiology of childhood uveitis.

Acta Ophthalmol 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To analyse the prevalence, incidence and aetiology of paediatric uveitis.

Methods: A retrospective, population-based cohort study of Finnish children with uveitis in Northern Ostrobothnia Hospital District in 2008-2017. The data included parameters for age, gender, age at diagnosis, laterality, chronicity, anatomical distribution of the disease, aetiology and systemic association. Read More

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http://dx.doi.org/10.1111/aos.14535DOI Listing

50 Years Ago in The Journal of Pediatrics: The Clinical Significance of Serologic Testing for Juvenile Idiopathic Arthritis: Then and Now.

Authors:
Philip J Hashkes

J Pediatr 2020 Jul;222:206

Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.jpeds.2020.01.040DOI Listing

Rheumatology practice amidst the COVID-19 pandemic: a pragmatic view.

RMD Open 2020 Jun;6(2)

Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon Academic Medical Centre, Lisbon, Portugal

The coronavirus disease 2019 (COVID-19) pandemic has come with many challenges for healthcare providers and patients alike. In addition to the direct burden it has placed on societies and health systems, it had a significant impact in the care of patients with chronic diseases, as healthcare resources were deployed to fight the crisis, and major travel and social restrictions were adopted. In the field of rheumatology, this has required notable efforts from departments and clinicians to adapt to the novel and assure the follow-up of patients with rheumatic and musculoskeletal diseases. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001314DOI Listing

[Rheumatic diseases in childhood and adolescence: importance of early multi-professional care].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2020 Jul;63(7):846-855

Programmbereich Epidemiologie, Arbeitsgruppe Kinderrheumatologie, Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Deutschland.

Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic disease in children. Both the disease, which is accompanied by pain and movement restrictions, and its usually complex, long-term therapy, are associated with burdens for those affected until adulthood. Impairments can affect many areas of life. Read More

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http://dx.doi.org/10.1007/s00103-020-03173-0DOI Listing

Parenchymal lung disease in adult onset Still's disease: an emergent marker of disease severity-characterisation and predictive factors from Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort of patients.

Arthritis Res Ther 2020 Jun 22;22(1):151. Epub 2020 Jun 22.

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, delta 6 building, PO box 67100, L'Aquila, Italy.

Background: Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown aetiology usually affecting young adults. Interestingly, recent evidence from the juvenile counterpart of AOSD suggested the emergent high fatality rate of lung disease (LD) in these patients. In this work, we aimed to characterise LD in AOSD, to identify associated clinical features and predictive factors, and to describe long-term outcomes of the disease comparing patients with LD and those without. Read More

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http://dx.doi.org/10.1186/s13075-020-02245-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310010PMC

Oral Complementary Medicine Use among People with Inflammatory Arthritis: An Australian Rheumatology Association Database Analysis.

Int J Rheumatol 2020 5;2020:6542965. Epub 2020 Jun 5.

Monash Department of Clinical Epidemiology, Cabrini Institute, Melbourne, Australia.

Objectives: To describe oral complementary medicine (CM) use in people with inflammatory arthritis, associations with use, and changes in use over time.

Methods: Demographic, clinical, and patient-reported outcome data from 5,630 participants with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA) were extracted from the Australian Rheumatology Association Database (ARAD), a national observational database. CM use at entry into ARAD was ascertained for participants recruited between 2002 and 2018. Read More

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http://dx.doi.org/10.1155/2020/6542965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293745PMC

Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases.

Clin Rev Allergy Immunol 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.

Type I interferons (IFN-Is) are a very important group of cytokines that are produced by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral, antitumor, and anti-proliferative effects, as well are associated with the initiation and maintenance of autoimmune disorders. Studies have shown that aberrantly expressed IFN-Is and/or type I IFN-inducible gene signatures in the serum or tissues of patients with autoimmune disorders are linked to their pathogenesis, clinical manifestations, and disease activity. Read More

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http://dx.doi.org/10.1007/s12016-020-08798-2DOI Listing

Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation.

Rheumatology (Oxford) 2020 Jun 18. Epub 2020 Jun 18.

Department of Infectious Diseases, Aarhus University Hospital.

Objectives: We investigated a patient with systemic juvenile idiopathic arthritis (sJIA) and recurrent macrophage activation syndrome (MAS) to discover genetic and immunological contributing factors.

Methods: Severe recurrent MAS motivated whole exome sequencing (WES) to identify genetic variants potentially involved in disease pathogenesis. In vitro peripheral blood mononuclear cell (PBMC) stimulations for cytokine expression and caspase-1 activity assays as well as NF-κB reporter luciferase assays were performed to functionally characterize variants. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa242DOI Listing

Adverse Childhood Experiences are Associated with Childhood-Onset Arthritis in a National Sample of US Youth: An Analysis of the 2016 National Survey of Children's Health.

J Pediatr 2020 Jun 15. Epub 2020 Jun 15.

Albert Einstein College of Medicine, Department of Pediatrics, Division of Developmental Medicine, Bronx, New York; Children's Hospital at Montefiore, Division of Developmental Medicine, Bronx, New York.

Objectives: To determine whether there is an association between adverse childhood experiences (ACEs) and childhood-onset arthritis, comparing youth with arthritis to both healthy youth and youth with other acquired chronic physical diseases (OCPD); and to examine whether ACEs are associated with disease-related characteristics among children with arthritis.

Study Design: In a cross-sectional analysis of data from the 2016 National Survey of Children's Health we examined whether ACEs were associated with having arthritis versus either being healthy or having a non-rheumatologic OCPD. ACE scores were categorized as 0, 1, 2-3, ≥4 ACEs. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.046DOI Listing

Image guided sacroiliac joint corticosteroid injections in children: an 18-year single-center retrospective study.

Pediatr Rheumatol Online J 2020 Jun 17;18(1):52. Epub 2020 Jun 17.

Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

Background: Sacroiliitis is commonly seen in enthesitis-related arthritis (ERA), a subtype of juvenile idiopathic arthritis (JIA). Sacroiliitis is characterized by the inflammation of the sacroiliac (SI) joints (+/- adjacent tissues). The treatment options include systemic therapy with or without corticosteroid SI joint injections. Read More

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http://dx.doi.org/10.1186/s12969-020-00435-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301971PMC

The musculoskeletal impairment negatively impacts the quality of life of children and adolescents with psoriasis.

Adv Rheumatol 2020 Jun 17;60(1):33. Epub 2020 Jun 17.

Pediatric Dermatology Division of the Department of Pediatrics, Federal University of Paraná, Curitiba, Paraná, Brazil.

Background: The severity of nail disease, the presence of arthralgia and fatigue are predictors of development of psoriatic arthritis (PsA) in patients with psoriasis (Pso). In children, little is known about the musculoskeletal (MSK) impairment in patients with Pso and its effect on health-related quality of life (HRQoL).

Objectives: To determine the frequencies of pain and MSK inflammation (i. Read More

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http://dx.doi.org/10.1186/s42358-020-00136-6DOI Listing

Efficacy and safety of canakinumab in systemic juvenile idiopathic arthritis: 48-week results from an open-label Phase III study in Japanese patients.

Mod Rheumatol 2020 Jun 17:1-24. Epub 2020 Jun 17.

Children's intractable disease rheumatism center, Fuji Toranomon Orthopedics Hospital, Shizuoka, Japan.

To assess the efficacy and safety of canakinumab in Japanese patients with systemic juvenile idiopathic arthritis (sJIA). This was an open-label, single-arm active treatment study. sJIA patients, aged ≥2-<20 years, were administered canakinumab 4 mg/kg every 4 weeks for ≤48 weeks. Read More

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http://dx.doi.org/10.1080/14397595.2020.1783163DOI Listing

Midfoot Arthritis in Children: Is There Any Relation With Malignancy?

Clin Med Insights Arthritis Musculoskelet Disord 2020 8;13:1179544120924643. Epub 2020 Jun 8.

Department of Pediatrics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Musculoskeletal symptoms are a presenting manifestation in a number of lymphoproliferative disorders including leukemia, especially in children. Among these primary symptoms, midfoot arthritis seems to be an important alarm for malignancy in children. The aim of this study is evaluation association of midfoot arthritis with malignancy in children. Read More

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http://dx.doi.org/10.1177/1179544120924643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281876PMC

Macrophage activation syndrome as a complication of dermatomyositis: A case report.

World J Clin Cases 2020 Jun;8(11):2339-2344

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Macrophage activation syndrome (MAS) can be a fatal complication of rheumatic disorders, which occurs most commonly in patients with systemic juvenile idiopathic arthritis or systemic lupus erythematosus. It has rarely been reported in patients with dermatomyositis. Here, we describe a fatal case of MAS that developed in an adult patient with dermatomyositis. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281037PMC

The Possible Relationship Between Familial Mediterranean Fever and Chronic Nonbacterial Osteomyelitis: Coincidence or Coexistence?

J Clin Rheumatol 2020 Jun 12. Epub 2020 Jun 12.

From the Departments of Pediatric Rheumatology.

Background/objectives: Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disease characterized by recurrent attacks and remissions due to sterile bone inflammation. The CNO may be accompanied by various inflammatory diseases. The aims of our study were to determine the clinical, laboratory, and radiological characteristics of children with CNO, and to investigate the possible effect of concomitant diseases on the course of CNO. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001431DOI Listing

Inflammatory Bowel Disease in Children with Systemic Juvenile Idiopathic Arthritis.

J Rheumatol 2020 Jun 15. Epub 2020 Jun 15.

Department of Pediatrics, Department of Medicine, and Department of Health Research & Policy, Stanford University School of Medicine, Stanford, CA;Department of Pediatrics, Children's Mercy Hospital, University of Missouri-Kansas City, Kansas City, MO; Department of Pediatrics, Saint Barnabas Medical Center and Children's Hospital of New Jersey, Livingston, NJ; Department of Pediatrics, Washington University School of Medicine, St Louis, MO; Paris University, Imagine Institute, RAISE Reference Centre and Necker Hospital, Assistance Publique Hopitaux de Paris, Paris, France; Department of Pediatrics and Department of Genetics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA; Department of Pediatrics, Boys Town National Research Hospital, Omaha, NE; Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Amsterdam Universitair Medische Centra, Amsterdam, Netherlands; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil; Department of Rheumatology and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel. Address correspondence to Dr. E.D. Mellins, Program in Immunology, Division of Human Gene Therapy, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5164, USA. Email:

Objective: The incidence of inflammatory bowel disease (IBD) in juvenile idiopathic arthritis (JIA) is higher than in the general pediatric population. However, reports of IBD in the systemic JIA (sJIA) subtype are limited. We sought to characterize sJIA patients diagnosed with IBD and to identify potential contributing risk factors. Read More

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http://dx.doi.org/10.3899/jrheum.200230DOI Listing

Fertility and sexuality of women with inflammatory arthritis.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 2;251:199-205. Epub 2020 Jun 2.

Department of Reproductive Medicine, Toulouse University Hospital, France; Groupe de Recherche en Fertilité Humaine (Human Fertility Research Group) EA 3694, Université Paul Sabatier, Toulouse, France. Electronic address:

Objective: This study aimed to evaluate the impact of the four main types of inflammatory arthritis (rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PA), juvenile chronic arthritis (JCA)) on female fertility.

Design: We performed a monocentric observational study, which took place in the Reproductive Medicine Department and the Rheumatology Department of the Toulouse University Hospital. An anonymous questionnaire was sent to patients aged 18-50 with RA, AS, PA or JCA who were diagnosed before the age of 40 and who consented to participate in the study. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.068DOI Listing

Alloplastic Temporomandibular Joint Reconstruction for Patients With Juvenile Idiopathic Arthritis.

J Oral Maxillofac Surg 2020 May 12. Epub 2020 May 12.

Program Director,Oral and Maxillofacial Surgery Department, The University of Texas-Health at San Antonio, San Antonio, TX. Electronic address:

Purpose: The purpose of this study was to assess the efficacy of alloplastic temporomandibular joint (TMJ) total joint replacement (TJR) in patients with juvenile idiopathic arthritis (JIA).

Materials And Methods: All patients with a formal diagnosis of JIA requiring a TMJ patient-specific TJR between 2010 and 2018 at The University of Texas-Health at San Antonio were retrospectively analyzed. To be included, patients must have had a formal diagnosis of JIA, complete records, and TMJ reconstruction with the TMJ Concepts patient-specific total joint prosthesis (TMJ Concepts, Ventura, CA). Read More

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http://dx.doi.org/10.1016/j.joms.2020.05.006DOI Listing

Intestinal microbiota and juvenile idiopathic arthritis: current understanding and future prospective.

World J Pediatr 2020 Jun 12. Epub 2020 Jun 12.

Department of Rheumatology, Capital Institute of Pediatrics, Beijing, China.

Background: Juvenile idiopathic arthritis (JIA) characterized by arthritis of unknown origin is the most common childhood chronic rheumatic disease, caused by both host genetic factors and environmental triggers. Recent evidence has mounted to focus on the intestinal microbiota, a potentially recognized set of environmental triggers affecting JIA development. Here we offer an overview of recently published animal and human studies that support the impact of intestinal microbiota in JIA. Read More

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http://dx.doi.org/10.1007/s12519-020-00371-3DOI Listing

Global prevalence estimates of three chronic musculoskeletal conditions: club foot, juvenile idiopathic arthritis and juvenile systemic lupus erythematosus.

Pediatr Rheumatol Online J 2020 Jun 12;18(1):49. Epub 2020 Jun 12.

Population Health Sciences Institute, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, Tyne and Wear, NE24HH, UK.

Background: Musculoskeletal (MSK) conditions are a major source of morbidity and disability. There is a lack of global comparable data on the burden of MSK conditions in children and young people. Our aim was to estimate the global prevalence of three MSK conditions - Talipes Equinovarus (Clubfoot), Juvenile Idiopathic Arthritis (JIA) and Juvenile Systemic Lupus Erythematosus (JSLE). Read More

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http://dx.doi.org/10.1186/s12969-020-00443-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291758PMC

Serious adverse events in children with juvenile idiopathic arthritis and other rheumatic diseases on tocilizumab - a real-world experience.

Semin Arthritis Rheum 2020 May 30;50(4):744-748. Epub 2020 May 30.

IMAGINE Institute, RAISE reference center for rare diseases, Department of Pediatric Immunology, Hematology and Rheumatology, Necker Hospital, AP-HP, Paris, France; Paris University, Paris, France. Electronic address:

Objectives: To assess the incidence rate and type of serious adverse events (SAE) in children with rheumatic inflammatory diseases treated with the interleukin 6 blocker tocilizumab (TCZ).

Methods: A retrospective review of all consecutive patients diagnosed with an inflammatory rheumatic disease and receiving at least one dose of TCZ was performed in two French tertiary pediatric rheumatology centers between 01/2007 and 06/2019. SAE were defined as a life-threatening event and/or an event requiring hospital admission, leading to permanent disability or treatment discontinuation. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.05.013DOI Listing

Periodic fever syndromes: a patient diagnosed with recurrent Kawasaki disease.

Cardiol Young 2020 Jun 11:1-3. Epub 2020 Jun 11.

Department of Pediatric Immunology, Faculty of Medicine, Ege University, Izmir, Turkey.

Kawasaki disease, known as mucocutaneous lymph node syndrome, is a multi-system disease of unknown aetiology that occurs in young children under 5 years of age. The recurrence rate of Kawasaki disease is as rare as 1-3%. Especially in cases with coronary artery involvement, recurrent Kawasaki disease should be investigated in terms of underlying rheumatologic diseases such as periodic fever syndromes, microscopic polyangiitis, polyarteritis nodosa, and systemic-onset juvenile arthritis. Read More

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http://dx.doi.org/10.1017/S1047951120001444DOI Listing

New medications are needed for children with juvenile idiopathic arthritis.

Arthritis Rheumatol 2020 Jun 10. Epub 2020 Jun 10.

Objectives: To document the need for additional FDA approved medications for the treatment of juvenile idiopathic arthritis (JIA).

Methods: The electronic medical record of JIA patients treated at Cincinnati Children's Hospital Medical Center (CCHMC) and data from JIA patients enrolled in the Childhood Arthritis & Rheumatology Research Alliance (CARRA) Registry were included in this study. Unmet medication need was measured in two ways: (A) presence of chronically uncontrolled JIA defined as a physician global-assessment of JIA activity (0-10; 0=inactive) ≥3 OR ≥3 active joints OR a patient global-assessment of well-being (0-10; 0=very well) ≥3, despite sequential use of ≥2 biologic disease-modifying anti-rheumatic drugs (bDMARDs); and (B) use of ≥1 bDMARD not approved for any JIA category. Read More

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http://dx.doi.org/10.1002/art.41390DOI Listing

Management of children with COVID-19: experiences from China.

World J Pediatr 2020 06;16(3):217-218

Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China.

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http://dx.doi.org/10.1007/s12519-020-00373-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284170PMC

Corneal endothelium in paediatric patients with uveitis: a prospective longitudinal study.

Br J Ophthalmol 2020 Jun 10. Epub 2020 Jun 10.

Department of Ophthalmology and Visual Sciences, University of Toronto, Toronto, Ontario, Canada.

Purpose: To study the longitudinal effect of anterior chamber inflammation on the corneal endothelium in children.

Methods: In this prospective longitudinal observational study, children (aged <18 years) with anterior chamber inflammation and those at risk of developing uveitis due to juvenile idiopathic arthritis (JIA) were included. Changes in central endothelial cell density (ECD) and morphological variables were determined by non-contact specular microscopy, and their correlations with uveitis activity and surgical interventions were analysed. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316120DOI Listing

Impact of core stability exercises on bone mineralization and functional capacity in children with polyarticular juvenile idiopathic arthritis: a randomized clinical trial.

Clin Rheumatol 2020 Jun 8. Epub 2020 Jun 8.

Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Background: Juvenile idiopathic arthritis (JIA) is the most prevalent rheumatic disease in children. The core stability exercises ensure proper muscular strength and balance around the lumbo-pelvic-hip complex.

Objective: This study evaluated whether the use of core stability exercises would increase the effectiveness of conventional physical therapy (PT) in enhancing bone mineralization and improving functional capacity in children with polyarticular JIA. Read More

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http://dx.doi.org/10.1007/s10067-020-05219-9DOI Listing

Efficacy and safety of switching from reference adalimumab to SB5 in a real-life cohort of inflammatory rheumatic joint diseases.

Clin Rheumatol 2020 Jun 8. Epub 2020 Jun 8.

Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Firenze, Via delle Oblate 4, 50141, Florence, Italy.

Objective: SB5 showed comparable efficacy and safety profile in respect to adalimumab originator (ADA) in randomized clinical trials of rheumatoid arthritis (RA) and psoriasis. We aimed to describe the efficacy and safety of SB5 after switching from ADA in RA, axial spondyloarthritis (axSpA), psoriatic arthritis (PsA) and juvenile idiopathic arthritis (JIA) patients.

Method: Adult RA, PsA, axSpA, JIA patients treated with ADA for at least 6 months, switched to SB5 in stable clinical conditions, were eligible. Read More

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http://dx.doi.org/10.1007/s10067-020-05199-wDOI Listing

Vitamin D Profile in Juvenile Idiopathic Arthritis Patients in a Tertiary Care Hospital in Bangladesh.

Mymensingh Med J 2020 Apr;29(2):311-316

Dr Sufia Khatun Sumi, Pediatrician, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh; E-mail:

There are multi-factorial causes of decrease in bone mass in Juvenile Idiopathic Arthritis (JIA) patients who correlate with the duration of active disease. By measuring the vitamin D level we can assess the deficiency or insufficiency earlier and can predict the risk of osteoporotic bone fracture & can give appropriate supplementation of vitamin D & calcium. This study was done to determine the status of serum 25(OH)D in patients with JIA and to see the relationship among various subtypes and disease duration. Read More

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Associated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER).

Semin Arthritis Rheum 2020 May 30;50(4):657-662. Epub 2020 May 30.

Rheumatology Department, University Hospital Complex, IRIDIS Group, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, Spain. Electronic address:

Objective: To assess the incidence of serious infection (SI) and associated factors in a large juvenile-onset systemic lupus erythematosus (jSLE) retrospective cohort.

Methods: All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet ≥4 ACR-97 SLE criteria and disease onset <18 years old (jSLE), were retrospectively investigated for SI (defined as either the need for hospitalization with antibacterial therapy for a potentially fatal infection or death caused by the infection). Standardized SI rate was calculated per 100 patient years. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.05.016DOI Listing

Abatacept in the treatment of localized scleroderma: A pediatric case series and systematic literature review.

Semin Arthritis Rheum 2020 May 19;50(4):645-656. Epub 2020 May 19.

Department of Pediatrics, University of New Mexico, 1127 University Blvd NE, MSC10, Albuquerque, NM 87131-0001, USA; Department of Dermatology, University of New Mexico, 1127 University Blvd NE, MSC10, Albuquerque, NM 87131-0001, USA.

Background: Localized scleroderma (LS) is a rare chronic immune-mediated skin condition of unknown etiology characterized by an inflammatory response in the skin and subcutaneous tissues resulting in collagen deposition and subsequent fibrosis. There is no cure for LS. No therapies have been licensed specifically for the treatment of LS and the clinical management of the disease remains largely empirical. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.03.020DOI Listing

Prevalence of co-existing autoimmune disease in juvenile idiopathic arthritis: a cross-sectional study.

Pediatr Rheumatol Online J 2020 Jun 5;18(1):43. Epub 2020 Jun 5.

Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Many autoimmune diseases share common pathogenic mechanisms, cytokine pathways and systemic inflammatory cascades; however, large studies quantifying the co-existence of autoimmune diseases in patients with juvenile idiopathic arthritis (JIA) have not been conducted.

Methods: We performed a cross-sectional study using two United States administrative healthcare claims databases (Truven Health MarketScan® Commercial Database and IMS PharMetrics database) to screen for the prevalence of multiple autoimmune diseases in patients with JIA and in a control group with attention deficit hyperactivity disorder (ADHD). Patients with a diagnosis code for JIA or ADHD between January 1, 2006 and September 30, 2017 were separated into two age cohorts (< 18 and ≥ 18 years) and matched (maximum 1:5) based on age, sex, number of medical encounters, and calendar year of diagnosis. Read More

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http://dx.doi.org/10.1186/s12969-020-00426-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275412PMC

Trochleitis presenting with double vision in a patient with juvenile idiopathic arthritis.

Orbit 2020 Jun 5:1-2. Epub 2020 Jun 5.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School , Boston, Massachusetts, USA.

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http://dx.doi.org/10.1080/01676830.2020.1772317DOI Listing

IL-21 CD4 T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis.

Clin Immunol 2020 May 30;217:108484. Epub 2020 May 30.

Pediatric Immunology, , Department of Pediatrics, University of Würzburg, Germany; Pediatric Rheumatology, Department of Pediatrics, University of Würzburg, Germany. Electronic address:

Juvenile Idiopathic Arthritis (JIA) is currently classified into seven subgroups. Recently, antinuclear antibody (ANA) positive JIA patients were suggested to encompass a clinically homogenous new subgroup. CD4 T helper (Th) cells play an essential role in JIA pathogenesis. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108484DOI Listing

Systemic Treatment for Temporomandibular Joint Arthritis in Juvenile Idiopathic Arthritis.

J Rheumatol 2020 Jun;47(6):793-795

Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.3899/jrheum.191169DOI Listing

Early joint replacement in juvenile idiopathic arthritis (JIA): trend over time and factors influencing implant survival.

Arthritis Care Res (Hoboken) 2020 May 31. Epub 2020 May 31.

ASST G.Pini-CTO, Milan, Italy.

Objective: To describe early prostheses implantation in a cohort of patients with juvenile idiopathic arthritis (JIA) followed in a tertiary referral hospital and to analyze possible factors influencing implant survival.

Methods: This is a retrospective cohort study. Charts of all JIA patients who underwent total joint replacement at G. Read More

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http://dx.doi.org/10.1002/acr.24337DOI Listing

"Pressure pain threshold over masticatory muscles and temporomandibular joint in patients with juvenile idiopathic arthritis".

J Oral Rehabil 2020 May 31. Epub 2020 May 31.

School of Orthodontics, Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples Federico II, Naples, Italy.

Background: Juvenile idiopathic arthritis (JIA) is an autoimmune, chronic, inflammatory joint disease, affecting children and adolescents. Patients with JIA may have pain and fatigue in muscles. There are not studies evaluating the pressure pain thresholds (PPTs) of both masticatory muscles and temporomandibular joint (TMJ) in patients with JIA. Read More

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http://dx.doi.org/10.1111/joor.13024DOI Listing

Posterior reversible encephalopathy syndrome (PRES) as a neurological association in severe Covid-19.

J Neurol Sci 2020 07 23;414:116943. Epub 2020 May 23.

Division of Neurology, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2020.116943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245308PMC

Long non‑coding RNA RP11‑340F14.6 promotes a shift in the Th17/Treg ratio by binding with P2X7R in juvenile idiopathic arthritis.

Int J Mol Med 2020 Aug 27;46(2):859-868. Epub 2020 May 27.

Department of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.

Long non‑coding RNA (lncRNAs) have been identified to play important roles in multiple human diseases via the regulation of cell proliferation, cell invasion, or cell death. However, little is known about the role of lncRNAs in the process of shifts in the Th17/Treg ratio during the progression of juvenile idiopathic arthritis (JIA). The aim of the present study was to determine the role of lncRNA RP11‑340F14. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4618DOI Listing

Pediatric Uveitis in a Referral Center in North Part of Turkey.

Ocul Immunol Inflamm 2020 May 28:1-5. Epub 2020 May 28.

Department of Ophthalmology, Ondokuz Mayis University, Samsun, Turkey.

: To analyze the demographic characteristics, clinical features, ocular complications, and visual outcome of pediatric patients with uveitis.: Retrospective evaluation of medical records.: The study included 156 eyes of 93 patients. Read More

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http://dx.doi.org/10.1080/09273948.2020.1758158DOI Listing

Self-healing juvenile cutaneous mucinosis, a sclerodermoid disorder simulating juvenile dermatomyositis: a case-based review.

Rheumatol Int 2020 Apr 22. Epub 2020 Apr 22.

Department of Pediatric Clinical Immunology and Rheumatology, Allergy Immunology Unit, Postgraduate Institute of Medical Education and Research, Advanced Pediatric Center, Chandigarh, 160012, India.

Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare childhood disease with characteristic cutaneous and rheumatic manifestations. Cutaneous manifestations include a combination of nodules affecting peri-articular (especially interphalangeal joints) and head and neck areas; and linearly arranged ivory white papules over an erythematous indurated skin. Despite a benign course, an abrupt onset of symptoms with extensive cutaneous involvement often leads to parental anxiety, overenthusiastic evaluation and sometimes aggressive treatment. Read More

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http://dx.doi.org/10.1007/s00296-020-04578-5DOI Listing
April 2020
1.627 Impact Factor

The Effects of Age and Cell Isolation on Collagen II Synthesis by Articular Chondrocytes: Evidence for Transcriptional and Posttranscriptional Regulation.

Biomed Res Int 2020 30;2020:4060135. Epub 2020 Apr 30.

Centre for OA Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK.

Adult articular cartilage synthesises very little type II collagen in comparison to young cartilage. The age-related difference in collagen II synthesis is poorly understood. This is the first systematic investigation of age-related differences in extracellular matrix synthesis in fresh articular cartilage and following isolation of chondrocytes. Read More

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http://dx.doi.org/10.1155/2020/4060135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212282PMC

Eric Bywaters a life story: 1 June 1910 to 2 April 2003.

Authors:
David Isenberg

Ann Rheum Dis 2020 May 26. Epub 2020 May 26.

Division of Medicine, UCL, Centre for Rheumatology Research, Division of Medicine UCL, London WC1E 6JF, UK

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http://dx.doi.org/10.1136/annrheumdis-2020-217153DOI Listing