79,579 results match your criteria Juvenile Rheumatoid Arthritis


Management of persistent juvenile angiofibroma after endoscopic resection: Analysis of a single institution series of 74 patients.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Background: Management of persistent juvenile angiofibroma (pJA) after transnasal endoscopic resection is controversial. To better understand its behavior, optimize treatment, and minimize morbidity, we report our experience in pJA focusing on follow-up strategies and disease progression.

Methods: A retrospective review of clinical records of all JA cases treated with endoscopic surgery at the Unit of Otorhinolaryngology of the University of Brescia between January 1994 and October 2015 was performed. Read More

View Article
December 2018

The Praxis of Decoloniality in Researcher Training and Community-Based Data Collection.

Am J Community Psychol 2018 Dec 11. Epub 2018 Dec 11.

Steinhardt School of Culture, Education, and Human Development, New York University, New York, NY, USA.

In this paper, we detail our praxis of decoloniality in the context of a community-based study that employs a quantitative experimental methodology to evaluate an intervention for girls involved in the juvenile legal system. We resist the essentializing of methodology that positions quantitative paradigms as impermeable to reflexivity and decoloniality, and describe a model for training and supervising researchers engaged in an experimental randomized controlled trial of an advocacy program for girls, most of whom are girls of color and about half of whom identify as LGBT. In this way, we consider researcher training as a critical teaching context and describe the ways in which our training, community-based data collection, and supervision structure are anchored in de/anti/post colonial and indigenous scholarships. Read More

View Article
December 2018

Cutaneous adult xanthogranuloma with a small portion of BRAF mutated Langerhans cell histiocytosis populations: A case report and the review of published work.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Histiocytoses, including Langerhans cell histiocytosis (LCH), juvenile or adult xanthogranuloma (AXG) and Rosai-Dorfman disease (RDD), are rare disorders characterized by the proliferation of cells derived from monocyte/macrophage lineages. A few cases of LCH coexisting with xanthogranuloma or RDD have been reported. The etiology of these diseases remains unclear. Read More

View Article
December 2018

Population Pharmacokinetics and Exposure-Response Modeling Analyses of Golimumab in Children With Moderately to Severely Active Ulcerative Colitis.

J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Global Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, PA, USA.

Population pharmacokinetics (PK) and exposure-response (E-R) analyses were conducted to compare the PK and E-R relationships of golimumab between children and adults with ulcerative colitis. PK data following subcutaneous golimumab administration to children with ulcerative colitis (6-17 years) in the PURSUIT-PEDS-PK study, adults with ulcerative colitis in the PURSUIT study, and children with pediatric polyarticular juvenile idiopathic arthritis (2-17 years) in the GO-KIDS study, were included in the population PK analysis. E-R analysis was conducted using logistic regression to link serum golimumab concentration and Mayo score-based efficacy outcomes in pediatric and adult ulcerative colitis. Read More

View Article
December 2018

Natural Concurrent Infection of Vibrio harveyi and V. alginolyticus in Cultured Hybrid Groupers in Malaysia.

J Aquat Anim Health 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Oral Biology, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

In September 2016, a marine fish farm operator in Selangor, Malaysia reported a disease outbreak affecting juvenile Hybrid Groupers (Camouflage Grouper Epinephelus polyphekadion x Tiger Grouper E. fuscoguttatus). The average daily mortality was 120 fish, resulting in a cumulative mortality rate of 29% within 10 days. Read More

View Article
December 2018

Changes in digestive enzyme activities during early ontogeny of Seriola rivoliana.

Fish Physiol Biochem 2018 Dec 8. Epub 2018 Dec 8.

Laboratorio de Fisiología Comparada y Genómica Funcional, Centro de Investigaciones Biológicas del Noroeste, La Paz, BCS, Mexico.

This study contributes to basic knowledge on the development of larval digestive enzyme activities of Seriola rivoliana, a carnivorous species that has shown high mortality in larval stage. The study was conducted under laboratory-controlled conditions until larvae reached 30 days after hatching (DAH). The specific activity of amylase and pepsin was analysed by spectrophotometric methods, and lipase, trypsin, chymotrypsin and alkaline phosphatase by fluorometry. Read More

View Article
December 2018

The clinical and imaging features of gray matter heterotopia: a clinical analysis on 15 patients.

Neurol Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.

Objective: To investigate the clinical and imaging features of gray matter heterotopia (GMH) and improve the clinicians' understanding of the disease.

Methods: A retrospective study was performed on 15 patients with GMH diagnosed at The Affiliated Hospital of Xuzhou Medical University from November 2014 to November 2016. Their clinical and imaging features are also summarized. Read More

View Article
December 2018

Isolation and Functional Analysis of Homolog From .

Front Plant Sci 2018 26;9:1743. Epub 2018 Nov 26.

Key Laboratory of Three Gorges Regional Plant Genetics & Germplasm Enhancement (CTGU)/Biotechnology Research Center, China Three Gorges University, Yichang, China.

() homologs are crucial regulators of flower development in angiosperms. In this study, we isolated the homolog from , a basal angiosperm belonging to the Magnoliaceae. Molecular phylogenetic analysis suggested that was grouped into the PI/GLO lineages of B-class MADS-box gene with the distinctive PI motif. Read More

View Article
November 2018

Pre-clinical Development of a Lentiviral Vector Expressing the Anti-sickling βAS3 Globin for Gene Therapy for Sickle Cell Disease.

Mol Ther Methods Clin Dev 2018 Dec 1;11:167-179. Epub 2018 Nov 1.

Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Sickle cell disease (SCD) is caused by a mutation (E6V) in the hemoglobin (Hb) β-chain that induces polymerization of Hb tetramers, red blood cell deformation, ischemia, anemia, and multiple organ damage. Gene therapy is a potential alternative to human leukocyte antigen (HLA)-matched allogeneic hematopoietic stem cell transplantation, available to a minority of patients. We developed a lentiviral vector expressing a β-globin carrying three anti-sickling mutations (T87Q, G16D, and E22A) inhibiting axial and lateral contacts in the HbS polymer, under the control of the β-globin promoter and a reduced version of the β-globin locus-control region. Read More

View Article
December 2018

Infectious and Noninfectious Acute Pericarditis in Children: An 11-Year Experience.

Int J Pediatr 2018 8;2018:5450697. Epub 2018 Nov 8.

Division of Infectious Diseases, Children's Hospital of Michigan, Detroit, MI, USA.

Objective: The study was undertaken to determine the etiology, review management, and outcome in children diagnosed with acute pericarditis during 11 years at tertiary pediatric institution.

Methods: Retrospective chart review of children diagnosed between 2004 and 2014. Patients with postsurgical pericardial effusions were excluded. Read More

View Article
November 2018

Feeding responses of the golden jackal after reduction of anthropogenic food subsidies.

PLoS One 2018 7;13(12):e0208727. Epub 2018 Dec 7.

Carnivore Ecology Research Group, Kaposvár University, Kaposvár, Hungary.

Little is known of the resources that limit or promote the rapidly expanding golden jackal (Canis aureus) population in Europe. We hypothesised that in an area of intensive big game hunting, a reduction of the main food resource (human subsidised big game viscera) would result in dietary switching. We used multivariate analyses to test whether the dietary composition of 200 jackal stomachs varied between two 2-yearly survey occasions, the first without big game viscera removal (availability of 68 kg viscera/year/km2) followed by a period with viscera removal (minimum of 50 kg of viscera/year/km2 removed). Read More

View Article
December 2018

Short-term Optic Disc Cupping Reversal in a Patient with Mild Juvenile Open-angle Glaucoma Due to Early Idiopathic Intracranial Hypertension.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Vanderbilt Eye Institute, Vanderbilt University Medical Center, 2311 Pierce Avenue, Nashville, TN, 37232.

Purpose: The purpose of this study is to report a case of optic disc cupping reversal in an adult without significant intraocular pressure lowering treatment.

Patient: A 20-year-old female with a history of mild juvenile open-angle glaucoma who developed subjective blurred vision and a decrease in cupping of her optic discs.

Results: Dilated examination demonstrated decreased cup-to-disc ratios in both eyes with slight blurring of the disc margin in the right eye. Read More

View Article
December 2018

Correlation of temporomandibular joint clinical signs with cone beam computed tomography radiologic features in juvenile idiopathic arthritis patients.

Stomatologija 2018 ;20(3):82-89

Department of Orthodontics, Institute of Stomatology, Riga Stradins University, Dzirciema 20, LV -1007, Riga, Latvia.

Objective: Patients with juvenile idiopathic arthritis (JIA) have a high risk of temporomandibular joint (TMJ) involvement. Early detection of osseous destruction of the TMJ that can be seen radiographically is vital to provide appropriate treatment before significant craniofacial deformities and problems with occlusion arise. The aim of study was to evaluate whether there is a correlation between the clinical signs and cone beam computed tomography (CBCT) radiologic features of TMJ in patients with JIA. Read More

View Article
January 2018

Aeromonas induced polyostotic osteomyelitis in a juvenile loggerhead sea turtle Caretta caretta.

Dis Aquat Organ 2018 Dec;132(1):79-84

Department of Veterinary Medicine and Animal Productions, University Federico II, 80137, Naples, Italy.

Bacterial bone infections have been occasionally reported in wild sea turtles. This study reports on a sub-adult Caretta caretta affected by Aeromonas hydrophila osteomyelitis, with extensive involvement of cranial and caudal flippers. The turtle was severely debilitated, had limited flipper mobility and showed signs of pain in reaction to manipulation. Read More

View Article
December 2018

Comprehensive Transcriptional Profiling of the Gastrointestinal Tract of Ruminants from Birth to Adulthood Reveals Strong Developmental Stage Specific Gene Expression.

G3 (Bethesda) 2018 Dec 10. Epub 2018 Dec 10.

University of Edinburgh

One of the most significant physiological challenges to neonatal and juvenile ruminants is the development and establishment of the rumen. Using a subset of RNA-Seq data from our high-resolution atlas of gene expression in sheep () we have provided the first comprehensive characterisation of transcription of the entire gastrointestinal (GI) tract during the transition from pre-ruminant to ruminant. The dataset comprises 164 tissue samples from sheep at four different time points (birth, one week, 8 weeks and adult). Read More

View Article
December 2018

The electroclinical features of idiopathic generalized epilepsy patients presenting with fixation-off sensitivity.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Epilepsy and Sleep Disorders Unit, Department of Neurology, The Fourth Military Medical University, Xi'an, 710032, China.

To determine the electroclinical features of fixation-off sensitivity (FOS) in patients with idiopathic generalized epilepsy (IGE). We searched the EEG database using the terms "fixation-off sensitivity" and "idiopathic generalized epilepsy" over a four-year period from March 2014 to April 2018 in the Xijing Hospital, Xi'an, China. FOS was evaluated according to the technique proposed by Panayiotopoulos. Read More

View Article
December 2018

Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

IRCCS Institute of Neurological Sciences, Bologna, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

We describe a 68-year-old woman who had typical absence seizures since 14 years of age. The absences were refractory to treatment and persisted into adulthood, with no seizure-free periods until seizure control at 59 years of age. After six years of being seizure-free, she presented with an episode characterized by mental confusion, abnormal behaviour, and amnesia, lasting for several hours. Read More

View Article
December 2018

Successful Slow Desensitization to Tocilizumab in a 15-Year-Old Patient.

J Investig Allergol Clin Immunol 2018 Dec;28(6):436-438

Erciyes University, School of Medicine, Department of Pediatrics, Division of Allergy, Kayseri, Turkey.

View Article
December 2018

Prenatal alcohol exposure and sleep-wake behaviors: exploratory and naturalistic observations in the clinical setting and in an animal model.

Sleep Med 2018 Oct 25;54:101-112. Epub 2018 Oct 25.

Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Introduction: Clinical research and studies using animal models have revealed a complex and relatively under-explored interaction between prenatal alcohol exposure (PAE) and alterations in sleep-wake behaviors.

Objectives: To utilize a structured naturalistic observation-based methodology, consisting of descriptive elements, to provide insight into possible links between altered sleep and disruptive daytime presentations in children and adolescents with fetal alcohol spectrum disorder (FASD). To apply a similar structured behavioral observation protocol in a PAE animal model to compare outcomes from the experimental and clinical studies utilizing naturalistic observational methodology. Read More

View Article
October 2018

Psychosocial complications in juvenile myoclonic epilepsy.

Epilepsy Behav 2018 Dec 7;90:122-128. Epub 2018 Dec 7.

Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Juvenile myoclonic epilepsy (JME) constitutes about 10% of all epilepsies. Because of executive dysfunction, people with JME may be prone to impulsivity and risk-taking behavior. Our aim was to investigate whether psychosocial issues associated with impulsivity are more prominent in people with JME than in those with other types of genetic generalized epilepsy (GGE). Read More

View Article
December 2018

Gene expression profiles of putative biomarkers in juvenile loggerhead sea turtles (Caretta caretta) exposed to polycyclic aromatic hydrocarbons.

Environ Pollut 2018 Nov 30;246:99-106. Epub 2018 Nov 30.

School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III Da Varano, I-62032, Camerino, MC, Italy. Electronic address:

There is evidence that polycyclic aromatic hydrocarbons (PAHs) are consistently the predominant organic contaminants in concentration found in loggerhead sea turtles (Caretta caretta) from the North and Central Adriatic Sea. Hence this study investigates the PAH toxicity to loggerheads by using a particular set of genes [i.e. Read More

View Article
November 2018

Understanding Commercially Sexually Exploited Youths' Facilitators and Barriers Towards Contraception Use: I Didn't Really Have A Choice.

J Pediatr Adolesc Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, David Geffen School of Medicine at UCLA and Mattel Children's Hospital, Los Angeles, CA, phone: (310) 206-1483, fax: (310) 206-4855, UCLA Pediatrics, Box 951752m 12-467 MDCC, Los Angeles, CA, United States, 90095-1752. Electronic address:

Study Objective: Given the high reproductive health risks that commercially sexually exploited youth (CSEY) face, we sought to understand facilitators and barriers related to their utilization of both condoms and hormonal contraception.

Design: We conducted semi-structured interviews with 21 females identified as CSEY. Interviews were audio-recorded, transcribed, and coded for emergent themes. Read More

View Article
December 2018

Reappraising localized juvenile spongiotic gingival hyperplasia.

J Am Dent Assoc 2018 Dec 7. Epub 2018 Dec 7.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion of unknown cause. The purpose of this study is to present a series of LJSGH cases and compare the findings with the literature.

Methods: After obtaining institutional review board approval, cases of biopsy-proven LJSGH from 2008 through 2018 were retrieved from the University of Pittsburgh Oral Pathology Biopsy Service archives and reviewed. Read More

View Article
December 2018

Toxicity of phenolic compounds to entomopathogenic nematodes: A case study with Heterorhabditis bacteriophora exposed to lentisk (Pistacia lentiscus) extracts and their chemical components.

J Invertebr Pathol 2018 Dec 4;160:43-53. Epub 2018 Dec 4.

Department of Entomology and Nematology, Agricultural Research Organization, The Volcani Center, Bet Dagan 50250, Israel.

Insects show adaptive plasticity by ingesting plant secondary compounds, such as phenolic compounds, that are noxious to parasites. This work examined whether exposure to phenolic compounds affects the development of insect parasitic nematodes. As a model system for parasitic life cycle, we used Heterorhabditis bacteriophora (Rhabditida; Heterorhabditiade) grown with Photorhabdita luminescens supplemented with different concentrations of plant phenolic extracts (0, 600, 1200, 2400 ppm): a crude ethanol extract of lentisk (Pistacia lentiscus) or lentisk extract fractionated along a scale of hydrophobicity with hexane, chloroform and ethyl acetate; and flavonoids (myricetin, catechin), flavanol-glycoside (rutin) or phenolic acids (chlorogenic and gallic acids). Read More

View Article
December 2018

Winner and loser effects in lobster cockroach contests for social dominance.

Horm Behav 2018 Dec 7. Epub 2018 Dec 7.

Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan, ROC.

In the context of animal aggression, the winner/loser effect is a cross-taxa phenomenon. In the present study, the effect of social contest experience on winning and losing subsequent encounters was investigated in the furious male lobster cockroach, Nauphoeta cinerea. Dominant and subordinate individuals were generated as the result of an encounter between two socially naïve males (SNMs); the winner and loser were designated as 1st encounter dominants and 1st encounter subordinates, respectively. Read More

View Article
December 2018

Medetomidine-ketamine-sevoflurane anaesthesia in juvenile Nile crocodiles (Crocodylus niloticus) undergoing experimental surgery.

Vet Anaesth Analg 2018 Sep 19. Epub 2018 Sep 19.

Department of Clinical Sciences and Services, The Royal Veterinary College, Hatfield, UK. Electronic address:

Objective: To describe the anaesthetic, physiological and side effects of intramuscular (IM) medetomidine and ketamine, followed by inhalational anaesthesia with sevoflurane, in Nile crocodiles (Crocodylus niloticus).

Study Design: Observational trial.

Animals: Ten juvenile captive-bred Nile crocodiles undergoing surgical implantation of skeletal beads and muscular electrodes. Read More

View Article
September 2018

Characteristic expressions of the natriuretic peptide family in the telencephalon of juvenile chick.

Brain Res 2018 Dec 5. Epub 2018 Dec 5.

College of Liberal Arts and Sciences, Kitasato University, Sagamihara, Kanagawa 252-0373, Japan. Electronic address:

Elucidation of the genes regulating the critical (sensitive) period of imprinting behavior may shed light on the mechanism underlying neural plasticity in early childhood learning. We focused on the family of natriuretic peptides (NPs) as candidates involved in the regulation of the critical period. In avians, several structurally related molecules comprised the NP family, including renal NP (RNP), B-type NP (BNP) and C-type NP (CNP1, CNP3 and CNPP). Read More

View Article
December 2018

Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis.

Best Pract Res Clin Rheumatol 2018 04 19;32(2):206-222. Epub 2018 Nov 19.

ARUK Centre for Epidemiology, Stopford Building, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, M13 9PT, UK. Electronic address:

Juvenile idiopathic arthritis (JIA) is the most common inflammatory joint condition of childhood and represents seven JIA subtypes characterised by distinct clinical and laboratory variables. Genetic and environmental factors are known to influence JIA, although many unanswered questions remain. Measurement of health outcomes in JIA is imperative for both clinical practice and research. Read More

View Article

Juvenile myoclonic epilepsy has hyper dynamic functional connectivity in the dorsolateral frontal cortex.

Neuroimage Clin 2018 Nov 19. Epub 2018 Nov 19.

Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Sweden.

Purpose: Characterize the static and dynamic functional connectivity for subjects with juvenile myoclonic epilepsy (JME) using a quantitative data-driven analysis approach.

Methods: Whole-brain resting-state functional MRI data were acquired on a 3 T whole-body clinical MRI scanner from 18 subjects clinically diagnosed with JME and 25 healthy control subjects. 2-min sliding-window approach was incorporated in the quantitative data-driven data analysis framework to assess both the dynamic and static functional connectivity in the resting brains. Read More

View Article
November 2018

Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20).

Arthritis Res Ther 2018 Dec 10;20(1):274. Epub 2018 Dec 10.

Department of Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.

View Article
December 2018

Seroprevalence and Related Factors of Toxoplasma gondii in Pigeons Intended for Human Consumption in Northern China.

Vector Borne Zoonotic Dis 2018 Dec 11. Epub 2018 Dec 11.

1 College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, PR China.

Toxoplasma gondii, the causative agent of toxoplasmosis, is carried by a range of intermediate hosts, including pigeons. Eating raw or undercooked pigeon meat, as is common in regions of China, can easily pass on a potentially fatal T. gondii infection. Read More

View Article
December 2018
1 Read

Juvenile rat and pediatric trazodone studies: how to gain extra sensitivity to overcome bioanalytical challenges.

Bioanalysis 2018 Dec 10. Epub 2018 Dec 10.

Angelini RR&D (Research, Regulatory & Development), Angelini SpA, Piazzale della Stazione snc, 00071 - S Palomba-Pomezia (Rome), Italy.

Aim: Trazodone (TZD) is used for the treatment of depression in adults and, off-label, as a sleep medication in adult and pediatric populations. The off-label use is well documented, however further clinical studies are needed to confirm its efficacy and safety for the treatment of sleep disorders. In this scenario, we developed a bioanalytical method to quantify low TZD concentrations in samples collected by capillary microsampling (CMS) to support dose finding, Good Laboratory Practice juvenile rat toxicokinetic and upcoming pediatric studies. Read More

View Article
December 2018

Psychology and public policy: A 50-year adventure.

Am Psychol 2018 Dec;73(9):1224-1235

Department of Psychology, University of Virginia.

This article provides an overview of my research on children, families, and the law over the past 50 years, while also providing the context for psychological research and action during this time period. The general framework requires using autobiographical information to understand my primary goal of contributing to a research base for intervention and policy change, especially within the juvenile justice system. Overall, my research and action endeavors have been related to prevention, children, and the legal system with changing foci over time: (a) changing juvenile correctional settings, (b) understanding and preventing child sexual abuse, (c) intervening with violent juveniles, (d) exploiting the myth of extreme recidivism rates among juvenile sex offenders, (e) understanding decision-making among youth in legal contexts, and (f) examining violence in teen dating relationships. Read More

View Article
December 2018

Combined juvenile polyposis syndrome and hereditary hemorrhagic telangiectasia (JPS/HHT) with MRI and endoscopic correlation.

Clin Imaging 2018 Dec 2;54:37-39. Epub 2018 Dec 2.

Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA.

Juvenile polyposis syndrome (JPS) may coexist with hereditary hemorrhagic telangiectasia (HHT) due to implication of the SMAD4 gene in a subset of both diseases. To the best of our knowledge, we present the first case in the radiologic literature on the MRI findings in a patient with this rare combined diagnosis undergoing workup for burden of disease. Read More

View Article
December 2018
2 Reads

An affinity peptide exerts antiviral activity by strongly binding nervous necrosis virus to block viral entry.

Fish Shellfish Immunol 2018 Dec 4;86:465-473. Epub 2018 Dec 4.

State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. Electronic address:

Nervous necrosis virus (NNV) causes viral nervous necrosis (VNN), a disease that leads to almost 100% mortality among larvae and juvenile fish, severely affecting the aquaculture industry. VNN vaccines based on inactivated viruses or virus-like particles (VLPs) are unsuitable for fish fry with immature adaptive immune systems. Here, we applied an anti-NNV strategy based on affinity peptides (AFPs). Read More

View Article
December 2018
1 Read

A databank for intracellular electrophysiological mapping of the adult somatosensory cortex.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurophysiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen - the Netherlands.

Background: Neurons in the supragranular layers of the somatosensory cortex integrate sensory (bottom-up) and cognitive/perceptual (top-down) information as they orchestrate communication across cortical columns. It has been inferred, based on intracellular recordings from juvenile animals, that supragranular neurons are electrically mature by the fourth postnatal week. However, the dynamics of the neuronal integration in the adulthood is largely unknown. Read More

View Article
December 2018
1 Read

Novel Paranannizziopsis species in a Wagler's viper (Tropidolaemus wagleri), tentacled snakes (Erpeton tentaculatum), and a rhinoceros snake (Rhynchophis boulengeri) in a zoological collection.

Med Mycol 2018 Dec 6. Epub 2018 Dec 6.

Mycology Unit, Facultat de Medicina i Ciències de la Salut and IISPV, University Rovira i Virgili, Reus, Spain.

We report several cases of fungal infections in snakes associated with a new species within the genus Paranannizziopsis. Three juvenile Wagler's vipers (Tropidolaemus wagleri) presented with skin abnormalities or ulcerative dermatitis, and two snakes died. Histologic examination of skin from the living viper revealed hyperplastic, hyperkeratotic, and crusting epidermitis with intralesional fungal elements. Read More

View Article
December 2018
3 Reads

Nervous system characterization during the development of a basal echinoderm, the feather star Antedon mediterranea.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Environmental Science and Policy, Università degli Studi di Milano, Milano, Italy.

Neural development of echinoderms has always been difficult to interpret, as larval neurons degenerate at metamorphosis and a tripartite nervous system differentiates in the adult. Despite their key phylogenetic position as basal echinoderms, crinoids have been scarcely studied in developmental research. However, since they are the only extant echinoderms retaining the ancestral body plan of the group, crinoids are extremely valuable models to clarify neural evolution in deuterostomes. Read More

View Article
December 2018
1 Read

Dataset on the numbers and proportion of mortality attributable to hunting, trapping, and powerlines in wild and captive-bred migratory Asian houbara .

Data Brief 2018 Dec 3;21:1848-1852. Epub 2018 Nov 3.

School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ, UK.

The data shown in this article are the number and proportion of deaths attributable to hunting/trapping, powerline collisions and natural causes in migratory Asian houbara originating from a breeding population in Uzbekistan. For wild adult and juvenile Asian houbara wintering in Central Asia during the period 2011-2018, 53.9% and 52. Read More

View Article
December 2018

Ecology and life history of (Araneae: Tetragnathidae) from Monte Albo (Sardinia, Italy).

Authors:
Enrico Lunghi

PeerJ 2018 29;6:e6049. Epub 2018 Nov 29.

Department of Biogeography, Trier University, Trier, Germany.

The orb-weaver spider Simon 1922 (Araneae: Tetragnathidae) is one of the most common cave predators occurring in the Mediterranean basin. Although the congeneric represented the model species in several studies, our knowledge of is only founded on observations performed on a handful of populations. In this study spiders were studied in caves of Monte Albo (Sardinia, Italy) over a year. Read More

View Article
November 2018

Overuse injuries in sport: a comprehensive overview.

J Orthop Surg Res 2018 Dec 5;13(1):309. Epub 2018 Dec 5.

Department of Musculoskeletal Disorders, School of Medicine and Dentistry, University of Salerno, Salerno, Italy.

Background: The absence of a single, identifiable traumatic cause has been traditionally used as a definition for a causative factor of overuse injury. Excessive loading, insufficient recovery, and underpreparedness can increase injury risk by exposing athletes to relatively large changes in load. The musculoskeletal system, if subjected to excessive stress, can suffer from various types of overuse injuries which may affect the bone, muscles, tendons, and ligaments. Read More

View Article
December 2018
3 Reads

Exploring the reason for increased activity of SHP2 caused by D61Y mutation through molecular dynamics.

Comput Biol Chem 2018 Oct 29;78:133-143. Epub 2018 Oct 29.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Juvenile myelomonocytic leukaemia, an aggressive myeloproliferative neoplasm, is characterized by thrombocytopenia, splenomegaly, fever and excess myelomonocytic cells. Approximately 35% of patients with JMML occur D61Y mutation in PTPN11, and it increases the activity of the protein. However, the effect of the D61Y mutation on SHP2 conformations in molecular basis is poorly understood. Read More

View Article
October 2018

Transformation of Recurrent Respiratory Papillomatosis: Squamous Cell Carcinoma in a Pregnant Teen.

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, Heart and Vascular Institute, Cleveland Clinic. Cleveland. Ohio. United States. Electronic address:

Recurrent Respiratory Papillomatosis (RRP) is a rare intractable benign disease with a bimodal age distribution. We present a rare case of malignant transformation of juvenile-onset RRP in a 19-year old pregnant female, who was found to have a right upper lobe mass and cavitary nodules bilaterally that were biopsy proven to be node negative, multifocal squamous cell carcinoma. In her second trimester, she underwent Video Assisted Thoracoscopic (VATS) right upper lobectomy and middle lobe lateral segmentectomy, followed by left lower lobe segmentectomy nine months later. Read More

View Article
November 2018

Cardiorespiratory fitness in long-term juvenile dermatomyositis: a controlled, cross-sectional study of active/inactive disease.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology, Oslo University Hospital, Rikshospitalet.

Objectives: To compare cardiorespiratory fitness (CRF) expressed as maximal oxygen uptake (VO2max) between patients with long-term JDM and controls and between patients with active and inactive disease, as well as to explore exercise limiting factors and associations between CRF and disease variables.

Methods: JDM patients (n = 45) and age- and gender-matched controls (n = 45) performed a cardiopulmonary exercise test (CPET) on a treadmill until exhaustion. Physical activity was measured by accelerometers. Read More

View Article
November 2018

Clinical and Genetic Features of Patients with Juvenile Amyotrophic Lateral Sclerosis with Fused in Sarcoma (FUS) Mutation.

Med Sci Monit 2018 Dec 3;24:8750-8757. Epub 2018 Dec 3.

Department of Neuromuscular Disorders, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND Juvenile amyotrophic lateral sclerosis (JALS) is a rare form of motor neuron disease and occurs before 25 years of age. Only a few cases of juvenile-onset ALS have been reported. MATERIAL AND METHODS To study genetic and clinicopathological features in Chinese patients with juvenile ALS, we retrospectively reviewed ALS patients in our hospital and screened out 2 patients with disease onset before the age of 25. Read More

View Article
December 2018

Contemporary management of juvenile angiofibroma.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 30. Epub 2018 Nov 30.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Purpose Of Review: To illustrate the latest developments and trends in the management of juvenile angiofibroma.

Recent Findings: Endoscopic surgery is currently the primary management strategy for juvenile angiofibroma. Recent reports on the use of multiportal approaches have contributed to further extend its indications. Read More

View Article
November 2018

Understanding mutuality: Unpacking relational processes in youth mentoring relationships.

J Community Psychol 2019 Jan 5;47(1):147-162. Epub 2018 Jul 5.

University of Virginia.

Evidence suggests that a close interpersonal bond is important for the success of youth-adult mentoring relationships. Mutuality has been suggested to be important for developing a close interpersonal bond (Rhodes, 2002, 2005), but mutuality remains an abstract construct, difficult to understand and cultivate. Using thematic analysis of mentor and mentee (n = 42) interviews, we investigate how mentoring pairs reflect on mutuality. Read More

View Article
January 2019

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.

Glia 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia.

The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate nervous system development and myelin regeneration after injury. In this study, we investigated the role of amyloid precursor protein (APP) and its paralogue amyloid precursor-like protein 2 (APLP2) in myelination using APP and APLP2 knockout (KO) mice. Given that BACE1 regulates myelination and myelin sheath thickness in both the peripheral and central nervous systems, we sought to determine if APP and APLP2, as alternate BACE1 substrates, also modulate myelination, and therefore provide a better understanding of the events regulating axonal myelination. Read More

View Article
December 2018