711 results match your criteria Juvenile Nasopharyngeal Angiofibroma


Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ent Department of ipo-Porto.

Clin Otolaryngol 2019 Feb 9. Epub 2019 Feb 9.

Otorhinolaryngology-Head and Neck Surgery Department, Instituto Português de Oncologia do Porto, Porto, Portugal.

Juvenile nasopharyngeal angiofibroma (JNA) is a benign, rare and highly vascular tumour, occurring in adolescent males. Clinical records of 27 patients who underwent surgical resection, performed between 1989 and 2017, were reviewed. Three patients were submitted to paralatero-nasal rhinotomy, 23 patients (85%), to the sublabial transnasomaxillary approach (Rouge Denker approach), complemented in 19 (70. Read More

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http://dx.doi.org/10.1111/coa.13309DOI Listing
February 2019
2 Reads

Implication of embolization in residual disease in lateral extension of juvenile nasopharyngeal angiofibroma.

J Oral Biol Craniofac Res 2019 Jan-Mar;9(1):115-118. Epub 2018 Dec 2.

Department of Otorhinolaryngology, King George Medical University, Lucknow, India.

A few studies have reported incomplete resection of juvenile nasopharyngeal angiofibroma (JNA) following embolization. The likely effects of embolization, viz. shrinkage/reduced tensile strength may have increased the fragility of tumour, leaving remnants postoperatively particularly across hour-glass constriction of sphenopalatine foramina. Read More

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http://dx.doi.org/10.1016/j.jobcr.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310683PMC
December 2018

Transoral Finger-Retraction for Endonasal Endoscopic Resection of Masseteric and Buccal Space Lesions.

J Craniofac Surg 2018 Dec 29. Epub 2018 Dec 29.

Department of Otolaryngology - Head and Neck Surgery.

Lesions involving the masseteric and buccal spaces have traditionally required transoral or transcervical approaches. Herein, the authors describe the successful endonasal endoscopic resection of a juvenile nasopharyngeal angiofibroma (JNA) with significant extension into the masseteric and buccal spaces facilitated by transoral finger retraction. Juvenile nasopharyngeal angiofibromas are hypervascular tumors originating in the pterygopalatine fossa (PPF) with complex relationships to skull base and orbital structures. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004931DOI Listing
December 2018

Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC).

Eur Arch Otorhinolaryngol 2018 Dec 21. Epub 2018 Dec 21.

Department of Virology, University of Helsinki, Helsinki, Finland.

Purpose: Approximately 20% of cancers are estimated to have a viral etiology. We aimed to investigate whether DNA of 8 human parvoviruses [bocavirus 1-4 (HBoV1-4), parvovirus B19 (B19V), protoparvoviruses (bufa-, tusa-, and cutavirus)] and 13 human polyomaviruses (HPyV) can be detected in oropharyngeal and oral cavity squamous cell carcinoma (OPSCC/OSCC), and in juvenile nasopharyngeal angiofibroma (JNA) tissue samples.

Methods: Fresh samples of seven JNA tissues and ten paired tissues of OSCC/OPSCC tumor and adjacent healthy tissues were collected. Read More

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http://link.springer.com/10.1007/s00405-018-5250-7
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http://dx.doi.org/10.1007/s00405-018-5250-7DOI Listing
December 2018
7 Reads

Juvenile nasopharyngeal angiofibroma in prepubertal males: A diagnostic dilemma.

Laryngoscope 2018 Dec 19. Epub 2018 Dec 19.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts.

Objectives/hypothesis: To highlight the presentation and management of juvenile nasopharyngeal angiofibroma (JNA) in prepubertal children.

Study Design: Single-institution 10-year retrospective review.

Methods: All identified cases of pathologically confirmed JNA in children <10 years of age were assessed from a gender, imaging and embolization findings, tumor stage, surgical approach, and clinical outcomes standpoint, and compared to a group of stage-matched older patients from the same time period. Read More

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http://doi.wiley.com/10.1002/lary.27633
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http://dx.doi.org/10.1002/lary.27633DOI Listing
December 2018
7 Reads

Nasopharyngeal angiofibroma in an elderly female patient: A rare case report.

Mol Clin Oncol 2018 Dec 5;9(6):702-704. Epub 2018 Oct 5.

Department of Sense Organs, Sapienza University of Rome, I-00186 Rome, Italy.

'Juvenile' nasopharyngeal angiofibroma, which accounts for <1% of all head and neck neoplasms, occurs predominantly in males between 10 and 18 years of age. The small number of patients older than 30 years confirms that presentation after this age is exceptional. Only rare cases of nasopharyngeal angiofibroma in female patients have been documented to date, and some authors believe that sex chromosome studies are indicated in such cases. Read More

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http://dx.doi.org/10.3892/mco.2018.1735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256179PMC
December 2018

Comparative Study between Conventional Method and Endonasal Endoscopic Resection of Juvenile Nasopharyngeal Angiofibroma.

Mymensingh Med J 2018 Oct;27(4):785-792

Dr KM Reza-Ul-Haq, Assistant Professor, Department of ENT and Head Neck Surgery, Delta Medical College, Mirpur, Dhaka, Bangladesh.

Juvenile Nasopharyngeal Angiofibroma (JNA) is an uncommon, benign and extremely vascular tumour which accounts for 0.05-0.5% of all head and neck tumours. Read More

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October 2018

Transnasal microscopic approach for juvenile nasopharyngeal angiofibroma.

Otolaryngol Pol 2018 Aug;72(5):31-36

Uniwersytet Medyczny w Lublinie II Wydział Lekarski z Oddziałem Anglojęzycznym Zakład Epidemiologii i Metodologii Badań Klinicznych.

Introduction: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign, vascular tumor originating in the nasopharynx. The treatment of choice for JNA is surgical excision. In recent years, surgical management has been greatly influenced by the use of the transnasal endoscopic technique. Read More

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https://otolaryngologypl.com/gicid/01.3001.0012.2303
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http://dx.doi.org/10.5604/01.3001.0012.2303DOI Listing
August 2018
5 Reads

Morbidity and Volumetric Progression in Juvenile Nasopharyngeal Angiofibroma in a Long-Term Follow-Up.

J Neurol Surg B Skull Base 2018 Dec 9;79(6):533-537. Epub 2018 Apr 9.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Switzerland.

 We compare the open and transnasal approaches for the excision of juvenile nasopharyngeal angiofibromas regarding the rate of morbidity, and residual tumor and its symptomatic recurrence over time. In addition, we present volumetric measurements of juvenile nasopharyngeal angiofibromas over time.  All surgically treated patients of our institution were reviewed back to 1969 for type of surgery, residual tumor by magnetic resonance imaging (MRI)-based volumetry, recurrence, and morbidity. Read More

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http://dx.doi.org/10.1055/s-0038-1635255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239873PMC
December 2018
7 Reads

Molecular interactions in juvenile nasopharyngeal angiofibroma: preliminary signature and relevant review.

Eur Arch Otorhinolaryngol 2019 Jan 1;276(1):93-100. Epub 2018 Nov 1.

Department of Otorhinolaryngology, Nepalgunj Medical College, Nepalgunj, Nepal.

Background: The molecular profile of juvenile nasopharyngeal angiofibroma (JNA) is extremely variable. In absence of established molecular signature the molecular targeting seems difficult for this heterogeneous disease. To establish a basic molecular signature, this paper analyses the interaction of 7 markers according to their ranks as per the decreasing scale of molecular expression. Read More

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http://link.springer.com/10.1007/s00405-018-5178-y
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http://dx.doi.org/10.1007/s00405-018-5178-yDOI Listing
January 2019
14 Reads

Juvenile nasopharyngeal angiofibroma: a single centre's 11-year experience.

J Laryngol Otol 2018 Nov 22;132(11):978-983. Epub 2018 Oct 22.

Department of Otorhinolaryngology,Faculty of Medicine,Hacettepe University,Ankara,Turkey.

Objective: This study aimed to present the clinical features and surgical outcomes of juvenile nasopharyngeal angiofibroma patients who were surgically treated.

Methods: The medical records of 48 male patients histologically confirmed as having juvenile nasopharyngeal angiofibroma, who underwent transnasal endoscopic surgery between 2005 and 2016, were retrospectively reviewed.

Results: The overall recurrence rate was 20. Read More

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http://dx.doi.org/10.1017/S0022215118001779DOI Listing
November 2018

Clinical correlation of molecular (VEGF, FGF, PDGF, c-Myc, c-Kit, Ras, p53) expression in juvenile nasopharyngeal angiofibroma.

Eur Arch Otorhinolaryngol 2018 Nov 31;275(11):2719-2726. Epub 2018 Aug 31.

Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, India.

Background: A molecular surrogate may exist for the clinical behaviour of juvenile nasopharyngeal angiofibroma (JNA).

Methods: In 9-14 cases, a 'correlation' of clinical behaviour with molecular expression (m-RNA expression through RT-PCR) of VEGF, FGF, PDGF, Ras, c-Myc, c-Kit and p53 was undertaken.

Results: A comparison of the two extremes of expressions characterized some specific clinical phenotypes for every marker except c-Myc. Read More

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http://link.springer.com/10.1007/s00405-018-5110-5
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http://dx.doi.org/10.1007/s00405-018-5110-5DOI Listing
November 2018
2 Reads

Radiation-Induced Sarcoma Originating in Recurrent Juvenile Nasopharyngeal Angiofibroma.

Case Rep Oncol Med 2018 15;2018:5695803. Epub 2018 Jul 15.

Department of Otolaryngology & Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.

Juvenile nasopharyngeal angiofibroma is a benign disease affecting young males with a propensity to invade intracranially and into the orbit along preformed pathways. Complete surgical excision is the mainstay of management. Patients with multiple recurrences along with tumour extension into skull base and orbit can be considered for external beam radiation as either adjuvant or definitive treatment. Read More

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http://dx.doi.org/10.1155/2018/5695803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079622PMC
July 2018
1 Read

Cerebrospinal Fluid Leak in Juvenile Nasopharyngeal Angiofibroma-Rare Sequelae of Flutamide-Induced Tumor Shrinkage.

World Neurosurg 2018 Dec 9;120:78-81. Epub 2018 Aug 9.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Nonsteroidal androgen receptor blockers like flutamide have been described as an adjuvant treatment for preoperative shrinkage of extensive juvenile nasopharyngeal angiofibroma. We present a case of cerebrospinal fluid (CSF) leak due to flutamide-induced tumor shrinkage.

Case Report: A 15-year-old male with a prior diagnosis of juvenile nasopharyngeal angiofibroma stage IIIB on preoperative flutamide for 3. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.288DOI Listing
December 2018
8 Reads

Juvenile nasopharyngeal angiofibroma surgical treatment in paediatric patients.

Acta Otorrinolaringol Esp 2018 Aug 6. Epub 2018 Aug 6.

Instituto Nacional de Salud del Niño, Lima, Perú.

Introduction And Objectives: The juvenile nasopharyngeal angiofibroma is a highly vascularised benign neoplasm of complex treatment in its surgical preparation, surgery to be performed, risks and recurrences. The aim of the study was to analyze the management and surgical treatment for the pathology of juvenile nasoangiofibroma.

Materials And Methods: We reviewed the clinical histories and images of the patients who underwent surgery with a pathology result of juvenile nasoangiofibroma in the period from January 2008 to December 2016. Read More

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http://dx.doi.org/10.1016/j.otorri.2018.06.003DOI Listing

Management and Outcome in Patients with Advanced Juvenile Nasopharyngeal Angiofibroma.

J Neurol Surg B Skull Base 2018 Aug 27;79(4):353-360. Epub 2017 Nov 27.

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

 To report the management outcome in a series of patients with advanced juvenile nasopharyngeal angiofibroma (JNA).  Retrospective study.  Tertiary care teaching hospital. Read More

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http://dx.doi.org/10.1055/s-0037-1608658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043168PMC
August 2018
14 Reads

Infratemporal fossa tumors: When to suspect a malignant tumor? A retrospective cohort study of 62 cases.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 10;135(5):311-314. Epub 2018 Jul 10.

Head and Neck Department, Lariboisière Hospital, University Paris 7, 2, rue Amboise-Paré, 75010 Paris, France.

Objectives: Infratemporal fossa (ITF) tumors are rare and little is known about their general epidemiology, making it sometimes difficult for clinicians, who seldom encounter them, to distinguish between benign and malignant forms on the basis of the initial clinical and radiological work-up alone. The objectives of this retrospective study were: (i) to determine the respective prevalences of the various histologic types of ITF tumor, and (ii) to assess associations between certain clinical and radiological features and malignancy.

Methods: A single-center observational study in a university hospital included all new consecutive cases of ITF tumor treated from January 2000 to December 2016. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.06.005DOI Listing
October 2018
1 Read

Endoscopic endonasal transmaxillary ligation of a feeding artery and coblation plasma technology enables en bloc resection of advanced juvenile nasopharyngeal angiofibroma without preoperative embolization.

Auris Nasus Larynx 2018 Jul 3. Epub 2018 Jul 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Juvenile nasopharyngeal angiofibroma (JNA) is a hypervascular tumor and uncontrolled hemorrhage makes its removal very difficult. Although preoperative intravascular embolization of a feeding artery is recommended, serious complications such as iatrogenic thrombosis in the brain and insufficient decrease in blood flow to the tumor are concerns. Recently, coblation plasma technology has been reported to be useful for tumor removal with minimum hemorrhage under a clear surgical field. Read More

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http://dx.doi.org/10.1016/j.anl.2018.06.007DOI Listing
July 2018
8 Reads

Juvenile Nasopharyngeal Angiofibroma: Our Experience in a Tertiary Hospital.

Indian J Otolaryngol Head Neck Surg 2018 Jun 22;70(2):273-277. Epub 2017 Nov 22.

2Department of ENT, Osmania Medical College, Hyderabad, India.

Nasopharyngeal angiofibroma is a highly vascular tumor seen typically in young adolescent males. It is an uncommon tumor accounting for less than 0.5% of all head and neck tumors. Read More

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http://dx.doi.org/10.1007/s12070-017-1205-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015575PMC

Assisted resection of lateral extension of juvenile nasopharyngeal angiofibroma using a sphenopalatine fossa dissector.

Authors:
A Mishra

J Laryngol Otol 2018 Jul 18;132(7):657-660. Epub 2018 Jun 18.

Department of Otorhinolaryngology,King George's Medical University,Lucknow,India.

Background: Juvenile nasopharyngeal angiofibroma often attaches firmly to the adjoining bony region around the sphenopalatine foramina-sphenopalatine fossa-pterygomaxillary fissure. This can result in hourglass-shaped constriction and predispose to incomplete resection (residual disease) with a transpalatal approach. This paper describes attempts to address this 'inaccessible' area with a novel instrument, used since 2012. Read More

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http://dx.doi.org/10.1017/S0022215118000798DOI Listing
July 2018
1 Read

Management of Epistaxis in Children and Adolescents: Avoiding a Chaotic Approach.

Pediatr Clin North Am 2018 06;65(3):607-621

Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, 4102 St. Antoine, 5E-UHC, Detroit, MI 48201, USA.

This article provides an organized foundation that facilitates the management of acute epistaxis and an understanding of features that merit further diagnostic workup. Prompt management, including measures such as holding pressure and using nasal packing, takes precedence over comprehensive diagnostic workup. Severe, recurrent, and posteriorly based bleeds should prompt consideration of alternate interventions and expert consultation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313955183002
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http://dx.doi.org/10.1016/j.pcl.2018.02.007DOI Listing
June 2018
30 Reads

Nasopharyngeal rhinosporidiosis with intracranial extension masquerading as juvenile angiofibroma: an unusual entity.

Br J Neurosurg 2018 May 10:1-4. Epub 2018 May 10.

a Department of Neuro-Surgery , Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER) , New Delhi , India.

Rhinosporidiosis is a chronic fungal inflammatory disease prevalent in India and Sri Lanka. Its manifestations are mostly nasal and extranasal lesions are relatively rare. Occasional atypical presentations of this disease lead to diagnostic dilemma. Read More

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http://dx.doi.org/10.1080/02688697.2018.1472215DOI Listing
May 2018
13 Reads
0.950 Impact Factor

Hypoxia-Inducible Factor-1α (HIF-1α) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis.

Ann Otol Rhinol Laryngol 2018 Jun 2;127(6):357-366. Epub 2018 May 2.

1 Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China.

Objective: To examine the expression of hypoxia-inducible factor-1α (HIF-1α) and its related molecules (cellular repressor of E1A-stimulated genes [CREG], osteopontin [OPN], proto-oncogene tyrosine-protein kinase Src [c-Src], and vascular endothelial growth factor [VEGF]) in juvenile nasopharyngeal angiofibroma (JNA) and explore the correlation between clinical prognosis and HIF-1α expression.

Methods: The study performed a retrospective review of the clinical records of patients with JNA treated between 2003 and 2007. Specimens were analyzed by immunohistochemistry for HIF-1α, CREG, OPN, c-Src, and VEGF expression, and microvessel density (MVD) was assessed by tissue microarray. Read More

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http://journals.sagepub.com/doi/10.1177/0003489418765563
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http://dx.doi.org/10.1177/0003489418765563DOI Listing
June 2018
6 Reads

Low CT Attenuation Values of Sinonasal Benign Tumours Relative to the Brainstem Identify Schwannomas.

ORL J Otorhinolaryngol Relat Spec 2018 17;80(1):41-50. Epub 2018 Apr 17.

Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Objectives: On computed tomography (CT), sinonasal schwannoma displays as a soft-tissue mass without any distinctive features. Our aim was to define the radiological criteria for distinguishing schwannoma from other sinonasal benign tumours.

Methods: We retrospectively identified consecutive patients who were pathologically diagnosed with benign sinonasal tumours between 2007 and 2016. Read More

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http://dx.doi.org/10.1159/000487240DOI Listing
November 2018
6 Reads

Differential Gene Expression and Pathway Analysis in Juvenile Nasopharyngeal Angiofibroma Using RNA Sequencing.

Otolaryngol Head Neck Surg 2018 Sep 10;159(3):572-575. Epub 2018 Apr 10.

1 Department of Otolaryngology-Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.

Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascularized and locally aggressive tumor that typically presents in adolescent males. The molecular biology of this tumor remains understudied. We sought to identify differentially expressed genes in the JNA transcriptome through messenger RNA sequencing of primary fibroblasts from 2 tumor explants and tonsil tissue from tumor-free subjects. Read More

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http://dx.doi.org/10.1177/0194599818769879DOI Listing
September 2018
5 Reads

Juvenile primary extranasopharyngeal angiofibroma, presenting as cheek swelling.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S73-S76

Department of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India.

Angiofibroma is a locally advancing immensely vascular tumor that essentially arises from the nasopharynx. The clinical characteristics of extranasopharyngeal angiofibroma (ENA) do not accord to that of nasopharyngeal angiofibroma and can present a diagnostic confront. We describe a case of primary juvenile ENA in a 19-year-old patient who presented with a rapidly enlarging mass of the cheek region. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_43_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824524PMC
January 2018
2 Reads

Facial Palsy Following Embolization of a Juvenile Nasopharyngeal Angiofibroma.

Ann Otol Rhinol Laryngol 2018 May 28;127(5):344-348. Epub 2018 Feb 28.

2 University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objectives: To describe a case of the rare complication of facial palsy following preoperative embolization of a juvenile nasopharyngeal angiofibroma (JNA). To illustrate the vascular supply to the facial nerve and as a result, highlight the etiology of the facial nerve palsy.

Methods: The angiography and magnetic resonance (MR) imaging of a case of facial palsy following preoperative embolization of a JNA is reviewed. Read More

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http://dx.doi.org/10.1177/0003489418761456DOI Listing
May 2018
6 Reads

Juvenile Nasopharyngeal Angiofibroma With Sphenoid Sinus Invasion and Protrusion: Treatment Approach With Le Fort I Osteotomy.

J Craniofac Surg 2018 Jun;29(4):e405-e408

Oral and Maxillofacial Surgery, PUCRS, Porto Alegre.

Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor that occurs predominantly in young males. The authors report the case of a 22-year-old male patient who presented with a painless, exophytic tumor mass protruding through the right nostril, with anterior lateral extension associated with severe posterior involvement, erosion of the sphenoid bone to the right of the pterygoid process, and significant epistaxis. The preoperative evaluation, surgical approach, postoperative results, and a review of the literature are presented. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004410DOI Listing
June 2018
16 Reads

Magnetic Resonance Imaging in Evaluation of Sinonasal Masses with Histopathological Correlation.

Mymensingh Med J 2018 Jan;27(1):26-33

Dr Mst Shahnwaz Begum, Assistant Professor, Prime Medical College & Hospital, Rangpur, Bangladesh.

Sinonasal mass is the abnormal growth of tissue from nasal cavity and mucosa of the paranasal sinuses. The growth may be benign or malignant. The benign lesion grows slowly and does not metastasize. Read More

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January 2018
3 Reads

Juvenile Nasopharyngeal Angiofibroma: Combined Approach for Excision, Transpalatal and Endoscopic; A New Perspective.

Indian J Otolaryngol Head Neck Surg 2018 Mar 19;70(1):125-129. Epub 2016 Oct 19.

Department of ENT Head and Neck Surgery, King George Medical University, Lucknow, 226003 India.

Juvenile angiofibroma is a rare, highly vascular, histologically benign but locally invasive tumour, affecting predominantly male adolescents. To describe our experience in diagnosis of angiofibroma and treatment by combined endoscopic and transpalatal route. We analysed a case series of 50 patients of nasopharyngeal angiofibroma in Fisch stages I and II who presented at our institute during a period of four years 2011-2014, their clinical presentation, their treatment by combined transpalatal and endoscopic approach, intraoperative and post operative course, complications and tumour recurrence. Read More

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http://dx.doi.org/10.1007/s12070-016-1027-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807276PMC
March 2018
1 Read

Cumulative sum analysis of the learning curve for endoscopic resection of juvenile nasopharyngeal angiofibroma.

Surg Endosc 2018 Jul 24;32(7):3181-3191. Epub 2018 Jan 24.

Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Background: To determine the learning curve with cumulative sum analysis for endoscopic resection of juvenile nasopharyngeal angiofibroma (JNA) and investigate whether the surgeon's expertise is a risk factor for recurrence.

Materials And Methods: We reviewed the medical records of patients with JNA who underwent endoscopic or endoscopic-assisted surgery between 2006 and 2015. We used cumulative sum (Cusum) analysis to plot the learning curve for operation time versus chronological sequence, and verified the Cusum curve by risk-adjusted Cusum (RA-Cusum) analysis. Read More

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http://dx.doi.org/10.1007/s00464-018-6035-1DOI Listing
July 2018
5 Reads

Angiofibroma Localized in the Sphenoid Sinus.

Case Rep Otolaryngol 2017 22;2017:4287293. Epub 2017 Nov 22.

Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.

Juvenile nasopharyngeal angiofibroma is the most common benign tumor of the nasopharynx with complaints of unilateral nasal obstruction and recurrent nosebleeds in the young male population. Despite being a benign tumor, it can be aggressively destructive in surrounding tissues and bones by acting locally. The gold standard treatment method is the surgical excision of the tumor. Read More

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http://dx.doi.org/10.1155/2017/4287293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735683PMC
November 2017
2 Reads

A rare case of extra-nasopharyngeal angiofibroma of the septum in a female child.

J Laryngol Otol 2018 Feb 16;132(2):184-187. Epub 2017 Nov 16.

Department of Otorhinolaryngology - Head and Neck Surgery,Lady Hardinge Medical College and Associated Hospitals,New Delhi,India.

Background: Extra-nasopharyngeal angiofibroma is a rare but distinct clinical entity, different from juvenile angiofibroma.

Methods: This clinical record elucidates the only case of extra-nasopharyngeal angiofibroma arising from the septum in a female child, who presented with epistaxis.

Results: The histopathological diagnosis was confirmed by immunohistochemistry, and the case was managed surgically with no recurrence. Read More

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http://dx.doi.org/10.1017/S0022215117002122DOI Listing
February 2018
10 Reads

Patterns of vascularization and surgical morbidity in juvenile nasopharyngeal angiofibroma: A case series, systematic review, and meta-analysis.

Head Neck 2018 02 11;40(2):428-443. Epub 2017 Nov 11.

Department of Otolaryngology - Head and Neck Surgery, Division of Rhinology, San Francisco, California.

Background: Vascular patterns of juvenile nasopharyngeal angiofibroma (JNA) are poorly defined. We performed both institutional and systematic literature reviews to characterize the relationship between arterial supply patterns of JNA with intraoperative blood loss and tumor recurrence.

Methods: A retrospective review of 26 patients with JNA treated at our institution from 1995 to 2015 with available angiograms, and systematic reviews and meta-analyses of 828 JNA cases undergoing angiographic embolization published between 1995 and 2015 were completed per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

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http://doi.wiley.com/10.1002/hed.24987
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http://dx.doi.org/10.1002/hed.24987DOI Listing
February 2018
13 Reads

Endoscopic Three-surgeon Six-handed Transorbital Transnasal Technique for Excision of Juvenile Nasopharygeal Angiofibroma: New Frontier Explored.

Asian J Neurosurg 2017 Oct-Dec;12(4):790-793

Department of Otorhinolaryngology, Royal Pearl Hospital, Tiruchirapally, Tamil Nadu, India.

Endoscopic endonasal transorbital approach has been described for the removal of orbital lesions located anteromedially in temporal fossa. The same has been observed to be a versatile approach to the anterior and middle cranial fossa only in laboratory studies. This is the first clinical report of combined transorbital transnasal endoscopic approach to the cavernous sinus, superior orbital fissure, and middle cranial fossa in a case of recurrent nasopharyngeal angiofibroma using the three-surgeon six-handed technique. Read More

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http://dx.doi.org/10.4103/1793-5482.181148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652126PMC
November 2017
10 Reads

Acquired Vascular Tumors of the Head and Neck.

Otolaryngol Clin North Am 2018 Feb 27;51(1):255-274. Epub 2017 Oct 27.

Department of Otolaryngology-Head and Neck Surgery, NYU School of Medicine, New York, NY, USA. Electronic address:

Vascular neoplasms of the head and neck present with a wide spectrum of signs and symptoms. Diagnosis requires a high index of suspicion and is usually made after tumors are large enough to be visually apparent or cause symptoms. This article discusses the most common acquired benign and malignant vascular tumors, with an emphasis on their evaluation and treatment. Read More

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http://dx.doi.org/10.1016/j.otc.2017.09.015DOI Listing
February 2018
11 Reads

Angiofibroma In A 50-Year-Old Patient.

J Ayub Med Coll Abbottabad 2017 Jul-Sep;29(3):499-501

Department of Medicine, Khyber Medical College, Peshawar, Pakistan.

Juvenile Angiofibroma (JNA) is a benign tumour that tends to bleed and occur in the nasopharynx with most cases occurring in pre-pubertal and adolescent males 10-20 years. We present the case of a 50-year-old male shopkeeper who consulted the ENT out patients' department (OPD) of Khyber Teaching Hospital (KTH) with the chief complaint of right sided nasal obstruction for the last 2.5 months which was associated with two episodes of epistaxis and diplopia which started 2 months back. Read More

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October 2017
17 Reads

Endoscopic endonasal approach for mass resection of the pterygopalatine fossa.

Clinics (Sao Paulo) 2017 Oct;72(9):554-561

Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University, University Hospital Motol, V Úvalu 84, 150 06, Prague 5, Czech Republic.

Objectives: Access to the pterygopalatine fossa is very difficult due to its complex anatomy. Therefore, an open approach is traditionally used, but morbidity is unavoidable. To overcome this problem, an endoscopic endonasal approach was developed as a minimally invasive procedure. Read More

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http://dx.doi.org/10.6061/clinics/2017(09)06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629706PMC
October 2017
12 Reads

Masses of the Nose, Nasal Cavity, and Nasopharynx in Children.

Radiographics 2017 Oct;37(6):1704-1730

From the Department of Radiology, Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH 43205 (D.P.R.); and Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio (E.S.O., B.L.K.).

A wide range of masses develop in the nose, nasal cavity, and nasopharynx in children. These lesions may arise from the nasal ala or other structures of the nose, including the mucosa covering any surface of the nasal cavity, the cartilaginous or osseous portion of the nasal septum, the nasal turbinates, and the nasal bones. Lesions may also arise from the nasopharynx or adjacent structures and involve the nose by way of direct extension. Read More

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http://dx.doi.org/10.1148/rg.2017170064DOI Listing
October 2017
38 Reads

The Four-Port Bradoo Technique: An Alternative to the Modified Endoscopic Denker's Approach for Giant JNA.

Indian J Otolaryngol Head Neck Surg 2017 Sep 28;69(3):277-281. Epub 2017 Jun 28.

Department of ENT and Head-Neck Surgery, Lokmanya Tilak Municipal Medical College and General Hospital (Sion Hospital), Room No 441, 4th Floor, College Building, Sion, Mumbai, 400022 India.

The aim of this study is to emphasise the importance of preserving the anterior facial skeleton in angiofibroma surgery and to introduce a new approach by which tumors with far lateral extensions can be operated upon successfully without disruption of the anterior facial skeleton. This is a prospective study conducted at a tertiary referral academic centre. Two patients with extensive juvenile nasopharyngeal angiofibroma with far lateral extensions were recruited and they underwent surgery between July and August 2016. Read More

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http://dx.doi.org/10.1007/s12070-017-1150-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581775PMC
September 2017
120 Reads

Cellular Angiofibroma of the Nasopharynx.

J Craniofac Surg 2017 Nov;28(8):e720-e722

Department of Otolaryngology Head and Neck Surgery, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey.

Angiofibroma is a common tumor of the nasopharynx region but cellular type is extremely rare in head and neck. A 13-year-old boy presented with frequent epistaxis and nasal obstruction persisting for 6 months. According to the clinical symptoms and imaging studies juvenile angiofibroma was suspected. Read More

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http://dx.doi.org/10.1097/SCS.0000000000003845DOI Listing
November 2017
10 Reads

Four-dimensional CT angiography (4D-CTA) in the evaluation of juvenile nasopharyngeal angiofibromas: comparison with digital subtraction angiography (DSA) and surgical findings.

Dentomaxillofac Radiol 2017 Dec 10;46(8):20170171. Epub 2017 Oct 10.

1 Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objectives: To explore the value of four-dimensional CT angiography (4D-CTA) in the preoperative evaluation of juvenile nasopharyngeal angiofibromas (JNAs) using 320-row volume CT.

Methods: 4D-CTA and DSA data of 18 patients with histopathologically proven JNAs were retrospectively reviewed. The location, extent, feeding vessels and stage of JNAs were assessed by two radiologists independently and blindly. Read More

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http://dx.doi.org/10.1259/dmfr.20170171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965941PMC
December 2017
16 Reads
1.271 Impact Factor

Perioperative airway management of a 16-year-old boy with progressive airway obstruction due to juvenile nasopharyngeal angiofibroma.

Clin Case Rep 2017 08 23;5(8):1274-1276. Epub 2017 Jun 23.

Department of Anesthesiology Sasaki Foundation Kyoundo Hospital Tokyo Japan.

Juvenile nasopharyngeal angiofibroma (JNA) involves difficult anesthetic management because of the risk of massive bleeding, while airway management is rarely a problem in JNA. This report presents an unusual case of JNA causing airway obstruction. Read More

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http://dx.doi.org/10.1002/ccr3.1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538053PMC
August 2017
7 Reads

Massive juvenile nasopharyngeal angiofibroma: ode to the open surgical approach.

BMJ Case Rep 2017 Aug 1;2017. Epub 2017 Aug 1.

Department of ENT, Maulana Azad Medical College, New Delhi, India.

The management of juvenile nasopharyngeal angiofibroma has undergone a significant evolution, with more surgeons moving towards the minimal invasive endoscopic approaches. Although considered the standard of care by most, an endoscopic approach may not be sufficient for extensive tumours, as exemplified by the current case of a young man presenting with the largest juvenile nasopharyngeal angiofibroma described in English literature until the present that was eventually excised via an anterior external approach. Read More

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http://dx.doi.org/10.1136/bcr-2016-218731DOI Listing
August 2017
6 Reads

Can Diffusion Weighted Imaging Aid in Differentiating Benign from Malignant Sinonasal Masses?: A Useful Adjunct.

Pol J Radiol 2017 28;82:345-355. Epub 2017 Jun 28.

Department of Otolaryngorhinology, All India Institute of Medical Sciences, New Delhi, India.

Background: To evaluate the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) values at 3 Tesla in characterizing sinonasal masses.

Material/methods: After ethical clearance, 79 treatment naive patients with head and neck masses underwent magnetic resonance imaging (MRI), including DWI at 3 Tesla using the following b values - 0, 500 and 1000 s/mm. Thirty-one patients were found to have sinonasal tumours and were subsequently analysed. Read More

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http://dx.doi.org/10.12659/PJR.900633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499628PMC
June 2017
25 Reads

Access Osteotomy in the Maxillofacial Skeleton.

Ann Maxillofac Surg 2017 Jan-Jun;7(1):98-103

Command Military Dental Centre, Lucknow, India.

Surgical accesses for the facial skeleton are based on the concept of modular osteotomies. Various techniques and combination of osteotomies facilitate access to the most inaccessible tumors of craniomaxillofacial region. Most appropriate surgical access is determined by considering size, location, extension of the tumor, and experience of the surgical team. Read More

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http://dx.doi.org/10.4103/ams.ams_88_12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502524PMC
July 2017
50 Reads

Inhibition of fibroblast growth factor receptor with AZD4547 mitigates juvenile nasopharyngeal angiofibroma.

Int Forum Allergy Rhinol 2017 10 14;7(10):973-979. Epub 2017 Jul 14.

Department of Otolaryngology, University of Kansas Medical Center and University of Kansas Cancer Center, Kansas City, KS.

Background: Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision is the mainstay of treatment, recurrences complicate treatment. There is a need to develop less invasive approaches for management. Read More

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http://dx.doi.org/10.1002/alr.21987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827962PMC
October 2017
8 Reads