744 results match your criteria Juvenile Nasopharyngeal Angiofibroma


Pediatric sinonasal and skull base lesions.

World J Otorhinolaryngol Head Neck Surg 2020 Jun 8;6(2):118-124. Epub 2020 Apr 8.

Department of Otolaryngology, Head and Neck Surgery, New York Presbyterian Hospital - Columbia University Medical Center, New York, NY, USA.

Pediatric skull base lesions are complex and challenging disorders. Safe and comprehensive management of this diverse group of disorders requires the expertise of an experienced multidisciplinary skull base team. Adult endoscopic skull base surgery has evolved due to technologic and surgical advancements, multidisciplinary team approaches, and continued innovation. Read More

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http://dx.doi.org/10.1016/j.wjorl.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296510PMC

Juvenile Nasopharyngeal Angiofibroma and Familial Adenomatous Polyposis.

Ear Nose Throat J 2020 Jun 16:145561320934602. Epub 2020 Jun 16.

Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.

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http://dx.doi.org/10.1177/0145561320934602DOI Listing

Mixed olfactory neuroblastoma and neuroendocrine carcinoma: An unusual case report and literature review.

Surg Neurol Int 2020 9;11:97. Epub 2020 May 9.

Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Medical Center, California, USA.

Background: The aim of the study was to present a case of mixed olfactory neuroblastoma (ONB) and carcinoma, an extremely rare tumor with only a few cases in the published literature.

Case Description: An otherwise healthy 27-year-old male presented with sinus complaints, headache, and unilateral eye discharge. Imaging and endoscopy revealed a mass presumed to represent a juvenile nasopharyngeal angiofibroma. Read More

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http://dx.doi.org/10.25259/SNI_473_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265421PMC

Olfaction in Juvenile Nasopharyngeal Angiofibroma: The first study.

Am J Otolaryngol 2020 Jul - Aug;41(4):102298. Epub 2019 Sep 10.

Department of Otorhinolaryngology and Head and Neck Surgery, King George's Medical University, Lucknow, India.

Background: To study the pattern of olfactory dysfunction/recovery in juvenile nasopharyngeal angiofibroma (JNA).

Methods: Olfactory assessment was undertaken in 30 patients (category1) both pre- & post-operatively and in another 18 (category 2) only postoperative. All patients underwent transpalatal excision and variables of interest included age, radiological stage/parameters & tumor size. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.102298DOI Listing
September 2019

Fusion 68Ga-Prostate-Specific Membrane Antigen PET/MRI on Postoperative Surveillance of Juvenile Nasal Angiofibroma.

Clin Nucl Med 2020 Jul;45(7):e325-e326

Nuclear Medicine.

Prostate-specific membrane antigen (PSMA) is expressed universally in juvenile nasopharyngeal angiofibroma (JNA). As contrast enhancement of postoperative scar is common with contrast-enhanced MRI (CEMRI), diagnosis of residual/recurrent JNA remains perplexing. Prostate-specific membrane antigen PET targets only the neovasculature and may aid in resolving this dilemma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003041DOI Listing
July 2020
3.931 Impact Factor

Robotic-assisted transmaxillary approach for removal of juvenile nasopharyngeal angiofibroma of the pterygopalatine and infratemporal fossa.

Head Neck 2020 May 4. Epub 2020 May 4.

Department of Otolaryngology-Head and Neck Surgery, West Virginia University Health Sciences Center, Morgantown, West Virginia, USA.

Endoscopic transmaxillary approaches to remove juvenile nasopharyngeal angiofibromas (JNAs) have been described previously and are used for tumors that extend laterally in the pterygopalatine fossa (PPF) and infratemporal fossa (ITF). There is no previous description of robotic-assisted JNA removal in the literature. The video will demonstrate the success of this technique. Read More

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http://dx.doi.org/10.1002/hed.26236DOI Listing

Juvenile Nasal Angiofibroma on Ga-DOTANOC PET/CT: Exploring Theranostic Avenues.

Indian J Nucl Med 2020 Apr-Jun;35(2):176-177. Epub 2020 Mar 12.

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Somatostatin (SST) cell surface receptors (SSTRs) are expressed in many different malignant, benign, and neuroendocrine tumors. SSTRs are also expressed in the endothelium of human vessels during angiogenesis and not in the nonproliferating vessels. We present a case of 19-year-old boy with juvenile nasal angiofibroma (JNA), who underwent Ga-DOTANOC PET/CT to explore SSTRs expression and theranostic potential. Read More

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http://dx.doi.org/10.4103/ijnm.IJNM_207_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182334PMC

The role of diagnostic and interventional radiology in juvenile nasopharyngeal angiofibroma: A case report and literature review.

Radiol Case Rep 2020 Jul 22;15(7):812-815. Epub 2020 Apr 22.

Department of Radiology, Faculty of Medicine Universitas Indonesia-Dr, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Juvenile Nasopharyngeal Angiofibroma is a rare and locally aggressive benign tumor. It is characterized by high vascularization leading to spontaneous bleeding or massive hemorrhage. We reported a case of 13 years old boy with a swollen at the right face, nasal congestion, recurrent nose bleeding, hyposmia, headache, breathing difficulty, and a nasopharyngeal mass at CT scan. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182694PMC

Clinical Applications of Ga-PSMA PET/CT on Residual Disease Assessment of Juvenile Nasopharyngeal Angiofibroma (JNA).

Nucl Med Mol Imaging 2020 Feb 18;54(1):63-64. Epub 2019 Dec 18.

2Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

We present a case of a 16-year-old boy who underwent Ga-PSMA PET/CT for residual disease assessment of juvenile nasal angiofibroma. Positive uptake was noted in residual tumor on PET/CT imaging. However, there was no abnormal uptake in surrounding scar tissues as compared with contrast-enhanced magnetic resonance imaging. Read More

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http://dx.doi.org/10.1007/s13139-019-00628-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062951PMC
February 2020

Comparison of 68Ga-PSMA PET/CT and Contrast-Enhanced MRI on Residual Disease Assessment of Juvenile Nasal Angiofibroma.

Clin Nucl Med 2020 Apr;45(4):308-309

Nuclear Medicine.

Prostate-specific membrane antigen (PSMA) is expressed in the endothelial cells of tumor-associated neovasculature of various nonprostatic benign and malignant neoplasms including juvenile nasopharyngeal angiofibroma (JNA). Positive uptake on PET/CT imaging with Ga-labeled PSMA is noted in a patient with residual disease after initial surgery without any abnormal uptake in postoperative fibrosis, in contrast to contrast-enhanced MRI, which was confirmed by biopsy. Ga-PSMA PET/CT may be a useful tool clinically for identifying early biochemical recurrences and in specifically differentiating recurrences from surgical site reparative tissue. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002951DOI Listing
April 2020
3.931 Impact Factor

Juvenile nasopharyngeal angiofibroma with intracranial extension - diagnosis and treatment.

Otolaryngol Pol 2019 Oct;74(2):1-7

Zakład Radiologii Zabiegowej i Neuroradiologii, Uniwersytet Medyczny w Lublinie.

Introduction: This retrospective study analyzes radiological findings, therapeutic management and outcomes of patients with intracranial extension of JNA. The routes of intracranial spread, incidence of intracranial disease and influence on therapeutic approach are discussed.

Material And Methods: An evaluation on the records of 62 patients with JNA was performed and 10 patients with intracranial tumors were included in the study. Read More

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http://dx.doi.org/10.5604/01.3001.0013.5275DOI Listing
October 2019

Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma.

Pediatr Blood Cancer 2020 04 11;67(4):e28162. Epub 2020 Jan 11.

Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute, Hemangioma and Vascular Malformations Center, University of Cincinnati, Cincinnati, Ohio.

Juvenile nasopharyngeal angiofibroma (JNA) is a pathologically benign yet locally aggressive and destructive tumor that develops in the choana and nasopharynx. Historical treatment of JNA has included embolization, surgical resection, and radiation. Here, we describe three patients who received therapy with the mTOR inhibitor sirolimus with improvement in clinical symptoms, imaging, and overall well-being. Read More

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http://dx.doi.org/10.1002/pbc.28162DOI Listing

Juvenile Nasopharyngeal Angiofibroma Outcomes and Cost: Analysis of the Kids' Inpatient Database.

Ann Otol Rhinol Laryngol 2020 May 26;129(5):498-504. Epub 2019 Dec 26.

Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.

Objective: To report trends in Juvenile Nasopharyngeal Angiofibroma (JNA) hospitalizations and identify key factors affecting treatment outcomes and cost of care in JNA patients.

Methods: The Healthcare Cost and Utilization Project (HCUP) Kids' Inpatient Database was queried for all cases of JNA between the years of 1997 and 2016. Key factors extracted were patient demographics, geographic region, hospital size, teaching status, elective admissions, and number of diagnoses and procedures performed during the hospitalization. Read More

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http://dx.doi.org/10.1177/0003489419896597DOI Listing

Trimodal embolization of juvenile nasopharyngeal angiofibroma with intracranial extension.

Int J Pediatr Otorhinolaryngol 2020 Mar 4;130:109805. Epub 2019 Dec 4.

Department of Otolaryngology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address:

Objectives/purpose: 1. Understand three different techniques for embolization of juvenile nasal angiofibroma (JNA) and assess their combined efficacy. 2. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.109805DOI Listing

From Juvenile Nasopharyngeal Angiofibroma to Nasopharyngeal Carcinoma; A Rare Case Report of Nasopharyngeal Mass.

Bull Emerg Trauma 2019 Oct;7(4):424-426

Department of Rhinology and Skull Base Surgery, ENT and Head and Neck Research Center, Hazrat Rasoul Hospital, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.

Nasopharyngeal masses in young males, first of all presumes Juvenile Nasopharyngeal Angiofibroma (JNA) in the mind, but other benign or malignant tumors should be considered for successful and adequate management of patients and also for minimizing morbidity from unnecessary interventions. We herein present a patient with nasopharyngeal carcinoma (NPC) mimicking JNA. The patient was presumed as JNA and underwent excessive surgical intervention and the final histopathology report was NPC. Read More

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http://dx.doi.org/10.29252/beat-070414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911716PMC
October 2019

[Primary juvenile nasal angiofibroma in a 38 year-old male (case report)].

Vestn Otorinolaringol 2019 ;84(5):76-80

N.N. Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia, 125047.

Juvenile nasal angiofibroma (JNA) is a benign, fibro-vascular, locally aggressive tumor with invasive growth patterns and high probability of recurrence. JNA present exclusively in adolescent boys between 9 and 19 years of age, total about 0.05% of head and neck tumors. Read More

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http://dx.doi.org/10.17116/otorino20198405176DOI Listing
January 2020

Massive Angiomatous Nasal Polyp Mimicking Nasopharyngeal Angiofibroma.

Indian J Otolaryngol Head Neck Surg 2019 Nov 15;71(Suppl 3):2114-2116. Epub 2018 Nov 15.

Department of ENT, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Angiomatous Nasal polyps is the rarest entity amongst the various types of nasal polyps known. It presents as mass filling the nasal cavity with extensions into surrounding structures; patients often presenting with symptoms of nasal obstruction and epistaxis, thus, mimicking nasal angiofibromas or malignancies. Here, we present a case of 16-year-old male, with complaints of unilateral nasal obstruction, intermittent epistaxis, anosmia, headache, ipsilateral epiphora and facial swelling. Read More

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http://dx.doi.org/10.1007/s12070-018-1536-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848473PMC
November 2019

Is 'Group and Save' Blood Request Routinely Required for Nasopharyngeal Biopsy?

Indian J Otolaryngol Head Neck Surg 2019 Nov 1;71(Suppl 3):1730-1733. Epub 2017 Feb 1.

2Department of Surgery, Delta State University, Abraka, Nigeria.

To establish our current practice of 'group and save' blood for nasopharyngeal tumour biopsy (NB), and to determine the rate of blood transfusions among patients who underwent NB under general anaesthesia. A retrospective chart review of all patients who underwent biopsy of NB in our tertiary institution between January 2006 and December 2015 was undertaken. Those with Juvenile nasopharyngeal angiofibroma were excluded. Read More

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http://dx.doi.org/10.1007/s12070-017-1078-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848325PMC
November 2019

Recurrence Rate after Endoscopic vs. Open Approaches for Juvenile Nasopharyngeal Angiofibroma: A Meta-analysis.

J Neurol Surg B Skull Base 2019 Dec 26;80(6):577-585. Epub 2018 Dec 26.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta Georgia, United States.

 The effect on recurrence rate between patients with juvenile nasopharyngeal angiofibroma (JNA), treated by an endoscopic versus open approach, has not been well established.  A meta-analysis of the available literature concerning recurrence rate in patients who underwent surgery for JNA.  A retrospective meta-analysis of studies analyzing recurrence rate after endoscopic or open surgery for patients with JNA was performed using the DerSimonian-Laird random-effects method. Read More

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http://dx.doi.org/10.1055/s-0038-1676562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864430PMC
December 2019

Case Report: Massive epistaxis from juvenile angiofibroma in an adolescent with severe haemophilia A.

F1000Res 2019 5;8:1593. Epub 2019 Sep 5.

Otorhinolaryngology, Philippine General Hospital, University of the Philippines, Ermita, Manila, 1000, Philippines.

Epistaxis may be profuse in individuals with normal bleeding parameters, but in an individual with haemophilia, it may be life-threatening. It is even more dangerous when epistaxis is caused by an undetected concomitant juvenile angiofibroma, and only one such case has been reported in the English literature. We report another case, of an 18-year-old Filipino adolescent with severe haemophilia A who was referred for repeated massive epistaxis. Read More

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http://dx.doi.org/10.12688/f1000research.20147.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758835PMC
June 2020
1 Read

Tissue microarray analysis reveals that cofilin expression is a poor prognostic factor in juvenile nasopharyngeal angiofibroma.

Int Forum Allergy Rhinol 2019 11 17;9(11):1273-1280. Epub 2019 Oct 17.

Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, People's Republic of China.

Background: Juvenile nasopharyngeal angiofibroma (JNA) has a high recurrence rate after surgery. Cofilin overexpression is associated with increased tumor cell metastasis, and progression of various human cancers. However, studies on cofilin expression in JNA are rare. Read More

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http://dx.doi.org/10.1002/alr.22413DOI Listing
November 2019
4 Reads

Endoscopic Resection of Pediatric Skull Base Tumors: An Evidence-Based Review.

J Neurol Surg B Skull Base 2019 Oct 11;80(5):527-539. Epub 2018 Dec 11.

Department of Otolaryngology - Head and Neck Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, United States.

 To perform a systematic review examining experiences with endoscopic resection of skull base lesions in the pediatric population, with a focus on outcomes, recurrence, and surgical morbidities.  PubMed/MEDLINE, Cochrane Library, Embase, and Web of Science databases were evaluated. Studies were assessed for level of evidence. Read More

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http://dx.doi.org/10.1055/s-0038-1676305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748853PMC
October 2019
6 Reads

Current perspectives on the origin theory of juvenile nasopharyngeal angiofibroma.

Discov Med 2019 06;27(150):245-254

Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China.

Juvenile nasopharyngeal angiofibroma (JNA) is a histopathologically benign and highly vascular neoplasm, which is mainly seen in young adolescent men. It is a rare tumor, accounting for 0.05% of all head and neck neoplasms. Read More

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June 2019
6 Reads

Posterior Nasal Pack After Transpalatal Excision of Juvenile Nasopharyngeal Angiofibroma: Can It be Avoided?

Indian J Otolaryngol Head Neck Surg 2019 Jun 7;71(2):278-281. Epub 2018 Feb 7.

Departments of Otorhinolaryngology, King George Medical University, Lucknow, India.

The evolution of the packing of postnasal space following transpalatal excision of JNA in the last 7 decades is described and a modification is presented for minimizing the immediate postoperative morbidity. Read More

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http://link.springer.com/10.1007/s12070-018-1267-x
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http://dx.doi.org/10.1007/s12070-018-1267-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582005PMC
June 2019
3 Reads

Occurrence of Hemi-Central Retinal Artery Occlusion Following Embolization in a Case of Recurrent Juvenile Nasopharyngeal Angiofibroma.

Ophthalmic Surg Lasers Imaging Retina 2019 06;50(6):385-387

Preoperative embolization is currently widely followed in the treatment of juvenile nasopharyngeal angiofibroma (JNA) to reduce intraoperative bleeding. However, embolization can result in untoward complications like stroke and blindness. The authors present the case of a 14-year-old boy with recurrent JNA who developed hemi-central retinal artery occlusion after embolization of branches of the external carotid artery. Read More

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http://dx.doi.org/10.3928/23258160-20190605-07DOI Listing
June 2019
5 Reads

Nasal Angiomyolipoma (AML) Mimicking Juvenile Nasopharyngeal Angiofibroma.

Iran J Otorhinolaryngol 2019 May;31(104):191-195

Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Introduction: Angiomyolipoma (AML), a benign mesenchymal tumor that commonly arises from the kidney, may be associated with tuberous sclerosis complex and perivascular epithelioid cell tumors (PEComas). Nasal angiomyolipoma is very rare and usually occurs in elderly individuals with epistaxis and nasal obstruction.

Case Report: We report a rare case of nasal angiomyolipoma in a young male. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556747PMC
May 2019
9 Reads

The Genetic and Molecular Determinants of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review.

Ann Otol Rhinol Laryngol 2019 Nov 31;128(11):1061-1072. Epub 2019 May 31.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, MA, USA.

Objective: Juvenile nasopharyngeal angiofibroma (JNA) is a rare vascular tumor of unknown etiology. Studies investigating the molecular and genetic determinants of JNA are limited by small sample size and inconsistent approaches. The purpose of this study is to examine all eligible JNA studies in aggregate, applying qualitative analysis to highlight areas of particular relevance, including potential targets for therapeutic intervention. Read More

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http://dx.doi.org/10.1177/0003489419850194DOI Listing
November 2019
4 Reads

Nasolacrimal Duct Management During Endoscopic Sinus and Skull Base Surgery.

Ann Otol Rhinol Laryngol 2019 Oct 14;128(10):932-937. Epub 2019 May 14.

1 Department of Otolaryngology-Head and Neck Surgery, New York University Langone Health, NY, USA.

Objective: To evaluate rates of epiphora after transection and marsupialization of the nasolacrimal duct (NLD) during endoscopic sinus and skull base surgery.

Introduction: The nasolacrimal canal forms part of the medial wall of the maxillary sinus. Transecting the NLD is sometimes necessary for tumor resection or surgical access to maxillary sinus and infratemporal fossa pathology. Read More

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http://dx.doi.org/10.1177/0003489419848454DOI Listing
October 2019
12 Reads

Nasopharyngeal Angiofibroma Staging with a Novel Nominal Basis: An 18-Year Study in a Tertiary Center.

Otolaryngol Head Neck Surg 2019 08 23;161(2):352-361. Epub 2019 Apr 23.

2 Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Objective: To develop a systematic method for anatomic mapping of juvenile nasopharyngeal angiofibroma (JNA) tumors to standardize communication, facilitate surgical planning, and convey prognosis.

Study Design: Retrospective cohort.

Setting: Tertiary referral center. Read More

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http://dx.doi.org/10.1177/0194599819842155DOI Listing
August 2019
131 Reads
1.721 Impact Factor

A Man with Juvenile Nasopharyngeal Angiofibroma, Vestibular Schwannoma, Cleft Lip and Cleft Palate, and Various Nevi: Case Report and Review.

Cureus 2018 Sep 14;10(9):e3304. Epub 2018 Sep 14.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Juvenile nasopharyngeal angiofibroma is a vascular tumor that typically occurs in men. Vestibular schwannoma (acoustic neuroma) is a tumor affecting the vestibulocochlear nerve. A 38-year-old man with various pigmented lesions and history of juvenile nasopharyngeal angiofibroma, vestibular schwannoma, and cleft lip and cleft palate is described. Read More

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http://dx.doi.org/10.7759/cureus.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417465PMC
September 2018
18 Reads

The risk factors for residual juvenile nasopharyngeal angiofibroma and the usual residual sites.

Am J Otolaryngol 2019 May - Jun;40(3):343-346. Epub 2018 Nov 22.

Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, No. 83, Fenyang Road, 200031 Shanghai, China. Electronic address:

Objective: Juvenile nasopharyngeal angiofibroma (JNA) is non-metastasizing but potentially locally destructive tumor of the nasopharynx. It can destroy the skull base and invade into the cerebrum. Surgical management is the primary standard but residual disease is always a risk factor. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.11.010DOI Listing
October 2019
7 Reads

Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ENT department of IPO-PORTO.

Clin Otolaryngol 2019 05 12;44(3):456-460. Epub 2019 Mar 12.

Department of Otorhinolaryngology-Head and Neck Surgery, Instituto Português de Oncologia do Porto, Porto, Portugal.

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http://dx.doi.org/10.1111/coa.13309DOI Listing
May 2019
11 Reads

Implication of embolization in residual disease in lateral extension of juvenile nasopharyngeal angiofibroma.

J Oral Biol Craniofac Res 2019 Jan-Mar;9(1):115-118. Epub 2018 Dec 2.

Department of Otorhinolaryngology, King George Medical University, Lucknow, India.

A few studies have reported incomplete resection of juvenile nasopharyngeal angiofibroma (JNA) following embolization. The likely effects of embolization, viz. shrinkage/reduced tensile strength may have increased the fragility of tumour, leaving remnants postoperatively particularly across hour-glass constriction of sphenopalatine foramina. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22124268183017
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http://dx.doi.org/10.1016/j.jobcr.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310683PMC
December 2018
10 Reads

Transoral Finger-Retraction for Endonasal Endoscopic Resection of Masseteric and Buccal Space Lesions.

J Craniofac Surg 2019 May/Jun;30(3):800-802

Department of Otolaryngology - Head and Neck Surgery.

Lesions involving the masseteric and buccal spaces have traditionally required transoral or transcervical approaches. Herein, the authors describe the successful endonasal endoscopic resection of a juvenile nasopharyngeal angiofibroma (JNA) with significant extension into the masseteric and buccal spaces facilitated by transoral finger retraction. Juvenile nasopharyngeal angiofibromas are hypervascular tumors originating in the pterygopalatine fossa (PPF) with complex relationships to skull base and orbital structures. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004931DOI Listing
July 2019
11 Reads

Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC).

Eur Arch Otorhinolaryngol 2019 Feb 21;276(2):613-617. Epub 2018 Dec 21.

Department of Virology, University of Helsinki, Helsinki, Finland.

Purpose: Approximately 20% of cancers are estimated to have a viral etiology. We aimed to investigate whether DNA of 8 human parvoviruses [bocavirus 1-4 (HBoV1-4), parvovirus B19 (B19V), protoparvoviruses (bufa-, tusa-, and cutavirus)] and 13 human polyomaviruses (HPyV) can be detected in oropharyngeal and oral cavity squamous cell carcinoma (OPSCC/OSCC), and in juvenile nasopharyngeal angiofibroma (JNA) tissue samples.

Methods: Fresh samples of seven JNA tissues and ten paired tissues of OSCC/OPSCC tumor and adjacent healthy tissues were collected. Read More

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http://link.springer.com/10.1007/s00405-018-5250-7
Publisher Site
http://dx.doi.org/10.1007/s00405-018-5250-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394423PMC
February 2019
32 Reads

Juvenile nasopharyngeal angiofibroma in prepubertal males: A diagnostic dilemma.

Laryngoscope 2019 08 19;129(8):1777-1783. Epub 2018 Dec 19.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts.

Objectives/hypothesis: To highlight the presentation and management of juvenile nasopharyngeal angiofibroma (JNA) in prepubertal children.

Study Design: Single-institution 10-year retrospective review.

Methods: All identified cases of pathologically confirmed JNA in children <10 years of age were assessed from a gender, imaging and embolization findings, tumor stage, surgical approach, and clinical outcomes standpoint, and compared to a group of stage-matched older patients from the same time period. Read More

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http://doi.wiley.com/10.1002/lary.27633
Publisher Site
http://dx.doi.org/10.1002/lary.27633DOI Listing
August 2019
32 Reads

Nasopharyngeal angiofibroma in an elderly female patient: A rare case report.

Mol Clin Oncol 2018 Dec 5;9(6):702-704. Epub 2018 Oct 5.

Department of Sense Organs, Sapienza University of Rome, I-00186 Rome, Italy.

'Juvenile' nasopharyngeal angiofibroma, which accounts for <1% of all head and neck neoplasms, occurs predominantly in males between 10 and 18 years of age. The small number of patients older than 30 years confirms that presentation after this age is exceptional. Only rare cases of nasopharyngeal angiofibroma in female patients have been documented to date, and some authors believe that sex chromosome studies are indicated in such cases. Read More

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http://dx.doi.org/10.3892/mco.2018.1735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256179PMC
December 2018
8 Reads

Comparative Study between Conventional Method and Endonasal Endoscopic Resection of Juvenile Nasopharyngeal Angiofibroma.

Mymensingh Med J 2018 Oct;27(4):785-792

Dr KM Reza-Ul-Haq, Assistant Professor, Department of ENT and Head Neck Surgery, Delta Medical College, Mirpur, Dhaka, Bangladesh.

Juvenile Nasopharyngeal Angiofibroma (JNA) is an uncommon, benign and extremely vascular tumour which accounts for 0.05-0.5% of all head and neck tumours. Read More

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October 2018
4 Reads

Transnasal microscopic approach for juvenile nasopharyngeal angiofibroma.

Otolaryngol Pol 2018 Aug;72(5):31-36

Uniwersytet Medyczny w Lublinie II Wydział Lekarski z Oddziałem Anglojęzycznym Zakład Epidemiologii i Metodologii Badań Klinicznych.

Introduction: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign, vascular tumor originating in the nasopharynx. The treatment of choice for JNA is surgical excision. In recent years, surgical management has been greatly influenced by the use of the transnasal endoscopic technique. Read More

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https://otolaryngologypl.com/gicid/01.3001.0012.2303
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http://dx.doi.org/10.5604/01.3001.0012.2303DOI Listing
August 2018
18 Reads

Morbidity and Volumetric Progression in Juvenile Nasopharyngeal Angiofibroma in a Long-Term Follow-Up.

J Neurol Surg B Skull Base 2018 Dec 9;79(6):533-537. Epub 2018 Apr 9.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, Switzerland.

 We compare the open and transnasal approaches for the excision of juvenile nasopharyngeal angiofibromas regarding the rate of morbidity, and residual tumor and its symptomatic recurrence over time. In addition, we present volumetric measurements of juvenile nasopharyngeal angiofibromas over time.  All surgically treated patients of our institution were reviewed back to 1969 for type of surgery, residual tumor by magnetic resonance imaging (MRI)-based volumetry, recurrence, and morbidity. Read More

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http://dx.doi.org/10.1055/s-0038-1635255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239873PMC
December 2018
11 Reads

Molecular interactions in juvenile nasopharyngeal angiofibroma: preliminary signature and relevant review.

Eur Arch Otorhinolaryngol 2019 Jan 1;276(1):93-100. Epub 2018 Nov 1.

Department of Otorhinolaryngology, Nepalgunj Medical College, Nepalgunj, Nepal.

Background: The molecular profile of juvenile nasopharyngeal angiofibroma (JNA) is extremely variable. In absence of established molecular signature the molecular targeting seems difficult for this heterogeneous disease. To establish a basic molecular signature, this paper analyses the interaction of 7 markers according to their ranks as per the decreasing scale of molecular expression. Read More

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http://link.springer.com/10.1007/s00405-018-5178-y
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http://dx.doi.org/10.1007/s00405-018-5178-yDOI Listing
January 2019
31 Reads

Juvenile nasopharyngeal angiofibroma: a single centre's 11-year experience.

J Laryngol Otol 2018 Nov 22;132(11):978-983. Epub 2018 Oct 22.

Department of Otorhinolaryngology,Faculty of Medicine,Hacettepe University,Ankara,Turkey.

Objective: This study aimed to present the clinical features and surgical outcomes of juvenile nasopharyngeal angiofibroma patients who were surgically treated.

Methods: The medical records of 48 male patients histologically confirmed as having juvenile nasopharyngeal angiofibroma, who underwent transnasal endoscopic surgery between 2005 and 2016, were retrospectively reviewed.

Results: The overall recurrence rate was 20. Read More

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http://dx.doi.org/10.1017/S0022215118001779DOI Listing
November 2018
4 Reads

Clinical correlation of molecular (VEGF, FGF, PDGF, c-Myc, c-Kit, Ras, p53) expression in juvenile nasopharyngeal angiofibroma.

Eur Arch Otorhinolaryngol 2018 Nov 31;275(11):2719-2726. Epub 2018 Aug 31.

Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, India.

Background: A molecular surrogate may exist for the clinical behaviour of juvenile nasopharyngeal angiofibroma (JNA).

Methods: In 9-14 cases, a 'correlation' of clinical behaviour with molecular expression (m-RNA expression through RT-PCR) of VEGF, FGF, PDGF, Ras, c-Myc, c-Kit and p53 was undertaken.

Results: A comparison of the two extremes of expressions characterized some specific clinical phenotypes for every marker except c-Myc. Read More

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http://link.springer.com/10.1007/s00405-018-5110-5
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http://dx.doi.org/10.1007/s00405-018-5110-5DOI Listing
November 2018
9 Reads

Radiation-Induced Sarcoma Originating in Recurrent Juvenile Nasopharyngeal Angiofibroma.

Case Rep Oncol Med 2018 15;2018:5695803. Epub 2018 Jul 15.

Department of Otolaryngology & Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.

Juvenile nasopharyngeal angiofibroma is a benign disease affecting young males with a propensity to invade intracranially and into the orbit along preformed pathways. Complete surgical excision is the mainstay of management. Patients with multiple recurrences along with tumour extension into skull base and orbit can be considered for external beam radiation as either adjuvant or definitive treatment. Read More

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http://dx.doi.org/10.1155/2018/5695803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079622PMC
July 2018
7 Reads

Cerebrospinal Fluid Leak in Juvenile Nasopharyngeal Angiofibroma-Rare Sequelae of Flutamide-Induced Tumor Shrinkage.

World Neurosurg 2018 Dec 9;120:78-81. Epub 2018 Aug 9.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Nonsteroidal androgen receptor blockers like flutamide have been described as an adjuvant treatment for preoperative shrinkage of extensive juvenile nasopharyngeal angiofibroma. We present a case of cerebrospinal fluid (CSF) leak due to flutamide-induced tumor shrinkage.

Case Report: A 15-year-old male with a prior diagnosis of juvenile nasopharyngeal angiofibroma stage IIIB on preoperative flutamide for 3. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.288DOI Listing
December 2018
20 Reads

Juvenile nasopharyngeal angiofibroma surgical treatment in paediatric patients.

Acta Otorrinolaringol Esp 2019 Sep - Oct;70(5):279-285. Epub 2018 Aug 6.

Instituto Nacional de Salud del Niño, Lima, Perú.

Introduction And Objectives: The juvenile nasopharyngeal angiofibroma is a highly vascularised benign neoplasm of complex treatment in its surgical preparation, surgery to be performed, risks and recurrences. The aim of the study was to analyze the management and surgical treatment for the pathology of juvenile nasoangiofibroma.

Materials And Methods: We reviewed the clinical histories and images of the patients who underwent surgery with a pathology result of juvenile nasoangiofibroma in the period from January 2008 to December 2016. Read More

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http://dx.doi.org/10.1016/j.otorri.2018.06.003DOI Listing
February 2020
7 Reads