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Am J Otolaryngol 2022 Jun 11;43(5):103532. Epub 2022 Jun 11.

ENT, Maulana Azad Medical College, India.

Introduction: Juvenile nasopharyngeal angiofibroma(JNA) are highly vascular benign tumours originating in the sphenopalatine fossa and may extend to the pterygopalatine fossa, paranasal sinuses, and nasal cavity. The management of JNA has evolved greatly with development of endoscopy. Treatment modality has changed from open approach to endoscopic approach due to various advantages offered by the endoscopic approach. Read More

Int Forum Allergy Rhinol 2022 Jun 11. Epub 2022 Jun 11.

Skull Base Surgery Unit Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamil Nadu, India.

Cureus 2022 Apr 21;14(4):e24350. Epub 2022 Apr 21.

Radiodiagnosis and Imaging, NKP Salve Institute of Medical Sciences and Research Center, Nagpur, IND.

Juvenile nasopharyngeal angiofibroma (JNA) is a very uncommon condition. We are presenting a case of a teenage boy with painless nasal blockage and fullness of bilateral ears for two to three months. On nasal endoscopy, a firm proliferative mass obstructing the right nasal cavity was noted. Read More

Vestn Otorinolaringol 2022 ;87(1):91-93

Russian Medical Academy for Continuous Professional Education, Moscow, Russia.

The objective of this article is to demonstrate a clinical case with a good outcome by using a maxillary swing approach during the surgical treatment of extensive locally advanced form of the juvenile nasopharyngeal angiofibroma (JNA) stage Fisch-Andrews IIIb (Radkowski IIIb). Thus the maxillary swing approach has given an adequate exposure of the skull base and is an effective approach in the surgical treatment of extensive JNA with a good overview of anatomical structures and has a minimal risk of complications and to evaluate an efficacy of the results. Read More

BMJ Case Rep 2022 Mar 8;15(3). Epub 2022 Mar 8.

Radiodiagnosis, Datta Meghe Institute of Medical Sciences - Wardha Campus, Wardha, Maharashtra, India

Int J Pediatr Otorhinolaryngol 2022 May 18;156:111089. Epub 2022 Feb 18.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address:

Background: Pediatric skull base surgeries are confined by developmental and anatomical issues. Radiofrequency coblation integrates the functions of ablation, suction, and coagulation with the ability to dissolve tissues with limited thermal injury, making it an ideal instrument for pediatric skull base surgery. We sought to evaluated the clinical outcomes of coblation-assisted pediatric endoscopic skull base surgery. Read More

Laryngoscope 2022 06 1;132(6):E25. Epub 2022 Mar 1.

Department of Nuclear Medicine Teaching Block, All India Institute of Medical Sciences, New Delhi, India.

Laryngoscope 2022 06 1;132(6):E23-E24. Epub 2022 Mar 1.

Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, Italy.

BMJ Case Rep 2022 Feb 7;15(2). Epub 2022 Feb 7.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.

Bleeding nasal mass in adolescent boys has customarily been attributed to Juvenile nasopharyngeal angiofibroma. However, little is known regarding the extranasopharyngeal origin of angiofibroma, as highlighted in this case report of a 15-year-old boy who presented with recurrent epistaxis and nasal obstruction. On constructing a working diagnosis of nasal haemangioma, the patient was taken up for endoscopic excision under general anaesthesia. Read More

Clin Nucl Med 2022 Mar;47(3):e268-e270

Pathology, All India Institute of Medical Sciences, New Delhi, India.

Abstract: We present the case of a left-sided recurrent juvenile nasopharyngeal angiofibroma (JNA) in a 16-year-old boy who underwent endoscopic excision 2 years back. The preoperative contrast-enhanced MRI and histopathology were in favor of JNA. The follow-up 68Ga-prostate-specific membrane antigen (PSMA) PET/CT scan at 3-month interval revealed complete clearance of disease. Read More

Oper Neurosurg (Hagerstown) 2022 Jan;22(1):e44-e45

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Juvenile angiofibroma is a rare benign expansive lesion typically affecting young men. Surgery is the current mainstay of treatment. Because it is a very vascular lesion, preoperative transarterial embolization can decrease intraoperative bleeding. Read More

Int J Dermatol 2021 Nov 8. Epub 2021 Nov 8.

Division of Hematology/Oncology, Creighton University School of Medicine, Omaha, NE, USA.

Background: Juvenile nasopharyngeal angiofibroma (JNA) is a rare but potentially life-threatening fibrovascular tumor that is seen almost exclusively in adolescent males and usually presents with symptoms of nasal obstruction or severe epistaxis. The current gold standard of treatment consists of complete surgical resection; however, this is inherently challenging because of the tumor's invasive nature and a substantial risk of intraoperative hemorrhage. Flutamide, an anti-androgen antineoplastic agent, has been used preoperatively in attempts to reduce tumor volume allowing for surgical resection with more conservative procedural techniques and reduce intraoperative blood loss. Read More

Neurol India 2021 Sep-Oct;69(5):1438-1441

Department of Otorhinolaryngology, All India Institute of Medical Sciences, Ansari Nagar, India.

Cureus 2021 Sep 29;13(9):e18378. Epub 2021 Sep 29.

Radiology, Dr Ziauddin University Hospital, Karachi, PAK.

Introduction Juvenile nasal angiofibroma (JNA) is a highly vascular tumor of the nasopharynx. Endovascular embolization followed by surgery is the treatment of choice. This study aimed to determine that single catheter technique with Gelfoam is an effective and safe technique for embolization to reduce the financial burden on patients in a developing country. Read More

Acute Med 2021 ;20(3):231-233

Acute Medicine, Arrowe Park Hospital, UK.

An adolescent male with a history of recurrent epistaxis presented with headache and vomiting. Investigations revealed concurrent meningitis as well as the presence of a subarachnoid haemorrhage. Subsequent imaging identified a Juvenile Nasopharyngeal Angiofibroma; a rare but important cause of meningitis that should be considered in the young adult population. Read More

Biomedicines 2021 Sep 18;9(9). Epub 2021 Sep 18.

Department of Clinical Genetics, University Hospital of Southern Denmark, 7100 Vejle, Denmark.

Juvenile nasopharyngeal angiofibroma (JNA) is a rare fibrovascular benign tumor showing an invasive growth pattern and affecting mainly male adolescents. We investigated the role of epithelial-mesenchymal transition (EMT) and WNT signaling pathways in JNA. Gene expression profiles using nine JNA paired with four inferior nasal turbinate samples were interrogated using a customized 2. Read More

J Neurol Surg B Skull Base 2021 Oct 20;82(5):547-555. Epub 2020 Aug 20.

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

 This study was aimed to understand the usefulness of transarterial angiography and embolization in management of juvenile nasopharyngeal angiofibroma (JNA) and to apply the information obtained to stage the disease, select appropriate surgical approach, predict intraoperative bleeding, and prognosticate the disease.  This study represents a retrospective review of the patients of JNA with major focus on transarterial angiography and embolization findings and its clinical and surgical implications.  The study conducted at a tertiary-care super-specialty referral center. Read More

J Clin Med 2021 Aug 31;10(17). Epub 2021 Aug 31.

Department of Otorhinolaryngology, ASST Lariana, University of Insubria, 22100 Como, Italy.

Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor of the nasal cavity that predominantly affects young boys. Surgical removal remains the gold standard for the management of this disease. Preoperative intra-arterial embolization (PIAE) is useful for reductions in intraoperative blood loss and surgical complications. Read More

Am J Rhinol Allergy 2022 Mar 5;36(2):207-215. Epub 2021 Sep 5.

28862Department of Pathology, Maulana Azad Medical College & Associated Hospitals, New Delhi, Delhi, India.

Background: The sinonasal region is affected by a variety of neoplasms. A differentiation between benign and malignant masses is essential both for management and prognostication. Morphological analysis often does not allow this differentiation. Read More

World Neurosurg 2021 11 25;155:180. Epub 2021 Aug 25.

Department of Otolaryngology-Head & Neck Surgery, Mayo Clinic in Arizona, Phoenix, Arizona, USA; Department of Neurosurgery, Mayo Clinic in Arizona, Phoenix, Arizona, USA. Electronic address:

Juvenile nasopharyngeal angiofibromas (JNAs) are highly vascularized benign lesions that mainly arise in adolescent male patients. Current treatment options include observation, radiotherapy, or surgical resection. Surgical resection is the treatment of choice as it achieves immediate and complete results, thereby minimizing the risk of recurrence. Read More

Int J Pediatr Otorhinolaryngol 2021 Oct 5;149:110871. Epub 2021 Aug 5.

Department of Otolaryngology - Head and Neck Surgery, Jacobs School of Medicine & Biomedical Sciences at the University at Buffalo, Buffalo, NY, USA. Electronic address:

Background: Juvenile nasopharyngeal angiofibroma (JNA) is a locally aggressive benign vascular tumor that typically afflicts young adolescent males. Historically removed via open approaches, these tumors are now being removed endoscopically. As the modern healthcare setting emphasizes value, efficient utilization of resources may lead to decreased cost while maintaining or improving patient outcomes. Read More

Laryngoscope 2022 06 10;132(6):1160-1165. Epub 2021 Aug 10.

Department of Neuroradiology, ASST Sette Laghi, Circolo Hospital, Varese, Italy.

Objectives/hypothesis: The aim of the present study is to validate and compare four of the most widely used staging systems for juvenile angiofibroma on a homogeneous cohort of patients.

Study Design: Retrospective case series.

Methods: A retrospective review of patients treated with endoscopic or endoscopic-assisted surgical resection between 1999 and 2020 was carried out. Read More

Cureus 2021 Jun 21;13(6):e15804. Epub 2021 Jun 21.

Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.

Objective The current mainstay treatment for juvenile nasopharyngeal angiofibromas (JNAs) is surgical resection, but embolization of primary feeding arteries through endovascular transarterial and direct tumoral puncture embolizations with various agents has been described. We describe a single institutional experience with JNA embolization utilizing Onyx (Medtronic, Dublin, Ireland). Methods A retrospective records review was performed to identify patients who underwent embolization for devascularization of Fisch grades II-IVa JNA (tumor extension beyond the sphenopalatine region) before surgical resection between 2010 and 2019. Read More

Vasc Endovascular Surg 2022 Jan 16;56(1):58-61. Epub 2021 Jul 16.

Department of Interventional Radiology, 8945Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, UK.

Preoperative embolisation of juvenile nasopharyngeal angiofibromas (JNAs) is a well-established treatment that reduces intraoperative blood loss and improves surgical outcomes. While the bulk of arterial supply to the tumour is derived from the external carotid system, some degree of contribution from the internal carotid artery (ICA) is common. ICA branch embolisation in this setting has previously been avoided due to concerns over ischaemic neurological complications, possibly contributing to the increased intraoperative blood loss observed in patients with tumours with ICA supply. Read More

Case Rep Oncol 2021 May-Aug;14(2):739-745. Epub 2021 May 27.

Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Juvenile nasopharyngeal angiofibroma (JNA) is a relatively uncommon, benign neoplasm of the nasopharynx that can be very difficult to diagnose early due to inconspicuous and seemingly harmless presenting symptoms. Early diagnosis and treatment of JNA are essential for a good prognosis. JNA typically responds well to radiation therapy (RT), but when it does not, the most appropriate next course of action has not been readily defined due to the limited occurrence and experience with this neoplasm. Read More

Ear Nose Throat J 2021 Jun 16:1455613211026517. Epub 2021 Jun 16.

Witwatersrand Health Sciences, Johannesburg, South Africa.

Juvenile nasopharyngeal angiofibroma is a benign vascular tumor seen predominantly in adolescent males in the second decade of life. Extranasopharyngeal angiofibroma includes vascular fibrous masses that occur outside the nasopharynx. The diagnosis of an angiofibroma is based on the clinical presentation and imaging, with biopsies being avoided to avoid excessive bleeding. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 05;56(5):544-545

Department of Otorhinolaryngology Head and Neck surgery, Sichuan Provincial Corps Hospital, Leshan 614000, Sichuan Province, China.

Int Arch Otorhinolaryngol 2021 Apr 30;25(2):e267-e272. Epub 2020 Jun 30.

Department of ENT, Government Medical College, Nalgonda, India.

 Ear, nose and throat (ENT)pathologies can present with proptosis as the early manifestation. The majority of ENT pathologies present with ocular manifestations, due to close anatomical relationship.  To study proptosis in ENT disorders in terms of etiology, pathogenesis, and management. Read More