1,328 results match your criteria Journal of vascular research[Journal]


Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells.

J Vasc Res 2019 Apr 17;56(1):39-53. Epub 2019 Apr 17.

Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

Natural direct current electric fields (DC EFs) within tissues undergoing angiogenesis have the potential to influence vessel formation, but how they affect endothelial cells is not clear. We therefore quantified behaviours of human umbilical vein endothelial cells (HUVEC) and human microvasculature endothelial cells (HMEC) stimulated by EFsin vitro. Both cell types migrated faster and toward the cathode; HUVECs responded to fields as low as 50mV/mm, but the HMEC threshold was 100 mV/mm. Read More

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http://dx.doi.org/10.1159/000495311DOI Listing

Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits.

J Vasc Res 2019 Apr 4;56(1):28-38. Epub 2019 Apr 4.

Department of Molecular Pathology, Faculty of Medicine, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi, Japan,

Background: Hypertension is a major risk factor for atherosclerotic disease. However, it is still not clear whether mechanical stress caused by hypertension directly affects the atherosclerotic development in the aorta and coronary arteries.

Objectives And Methods: We generated a hypertensive (HTN) rabbit model by surgical removal of the left kidney and partial ligation of the right renal artery. Read More

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http://dx.doi.org/10.1159/000498897DOI Listing
April 2019
1 Read

Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-Îł/HO-1 Pathway.

J Vasc Res 2019 Mar 15;56(1):17-27. Epub 2019 Mar 15.

Division of Spine, Department of Orthopedics, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai, China,

Vitamin D has an important protective effect on chronic inflammatory disease. Angiotensin II (AngII) triggers vascular damage and plays a key role in vascular diseases via several mechanisms, including inflammation. Conversely, vitamin D has been shown to have an important protective effect on chronic inflammation. Read More

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https://www.karger.com/Article/FullText/496164
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http://dx.doi.org/10.1159/000496164DOI Listing
March 2019
8 Reads

Erratum.

Authors:

J Vasc Res 2019 Feb 14;56(1):16. Epub 2019 Feb 14.

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http://dx.doi.org/10.1159/000497305DOI Listing
February 2019
1 Read

Marked Vascular Dysfunction in a Case of Peripartum Cardiomyopathy.

J Vasc Res 2019 Feb 14;56(1):11-15. Epub 2019 Feb 14.

Stanford Cardiovascular Institute, Stanford, California, USA,

Peripartum cardiomyopathy (PPCM) is a rare form of congestive heart failure characterized by left ventricular dysfunction that develops towards the end of pregnancy or during the early postpartum phase. Even though the majority of PPCM patients show partial or complete recovery of their heart functions, the mortality rate of PPCM remains high. Previous research has suggested that vascular dysfunction triggered by late-gestational hormones and potent anti-angiogenic factors play key roles in the pathogenesis of PPCM; however, the exact mechanisms remain elusive due to limited patient tissues for characterization. Read More

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http://dx.doi.org/10.1159/000496163DOI Listing
February 2019

Panax notoginseng Saponins Ameliorate Leukocyte Adherence and Cerebrovascular Endothelial Barrier Breakdown upon Ischemia-Reperfusion in Mice.

J Vasc Res 2019 Feb 14;56(1):1-10. Epub 2019 Feb 14.

Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Panax notoginseng saponins (PNS) are known as clinical anti-stroke herbal medicines. The aim of this study is to describe the impact of PNS on ischemia-reperfusion-induced cerebral microvasculature barrier dysfunction which has not been investigated yet. Mice were subjected to transient middle cerebral artery occlusion and PNS were administrated to mice 3 days before and 2 days after surgery. Read More

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http://dx.doi.org/10.1159/000494935DOI Listing
February 2019
2 Reads

Glycyrrhizin, a High-Mobility Group Box 1 Inhibitor, Improves Lipid Metabolism and Suppresses Vascular Inflammation in Apolipoprotein E Knockout Mice.

J Vasc Res 2018 16;55(6):365-377. Epub 2019 Jan 16.

Department of Cardiology, First College of Clinical Medical Sciences, China Three Gorges University, Yichang, China.

Background: High-mobility group box protein 1 (HMGB1) is known to have proinflammatory properties; however, the mechanisms by which HMGB1 influences immune responses during atherosclerosis (AS) development are not well understood. Thus, this study investigated the relationship between HMGB1 and vascular inflammation in Apoe-/- mice and whether glycyrrhizin (GLY), a small inhibitor of HMGB1, could have atheroprotective effects in AS.

Methods: Apoe-/- mice on a high-fat diet were treated with GLY (50 mg/kg) or vehicle by gavage once daily for 12 weeks, respectively. Read More

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https://www.karger.com/Article/FullText/495310
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http://dx.doi.org/10.1159/000495310DOI Listing
January 2019
10 Reads

Advanced Methods for the Investigation of Cell Contact Dynamics in Endothelial Cells Using Florescence-Based Live Cell Imaging.

J Vasc Res 2018 13;55(6):350-364. Epub 2018 Dec 13.

Institute of Anatomy and Vascular Biology, Westfälische Wilhelms-Universität Münster, Münster, Germany,

Endothelial cells of the vascular system are dynamic cells whose molecular adaptability is decisive for the adjustment of homeostasis and organ perfusion. Advanced microscopic techniques, automation processing, and image analysis software was shown to improve the understanding of vascular biology. In this work, we describe advanced methods that allow investigating the dynamics of endothelial cell contacts. Read More

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https://www.karger.com/Article/FullText/494933
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http://dx.doi.org/10.1159/000494933DOI Listing
December 2018
3 Reads

Vascular Remodeling Process of Heparin-Conjugated Poly(ε-Caprolactone) Scaffold in a Rat Abdominal Aorta Replacement Model.

J Vasc Res 2018 28;55(6):338-349. Epub 2018 Nov 28.

Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing, China,

In the field of vascular graft research, poly-ε-caprolactone (PCL) is used owing to its good mechanical strength and biocompatibility. In this study, PCL scaffold was prepared by electrospinning and surface modification with heparin via hexamethylenediamine. Then the scaffolds were implanted into the infrarenal abdominal aorta of Wistar rats and contrast-enhanced micro-ultrasound was used to monitor the patency of grafts after implantation. Read More

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http://dx.doi.org/10.1159/000494509DOI Listing
November 2018
4 Reads
2.901 Impact Factor

Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction.

J Vasc Res 2018 8;55(6):329-337. Epub 2018 Nov 8.

Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan.

Purpose: To determine: (1) whether variables of a pulse wave form analysis of ocular microcirculation shown by laser speckle flowgraphy (LSFG) correlate with left ventricular (LV) systolic dysfunction and (2) whether these variables correlate with LV diastolic dysfunction in subjects without LV systolic dysfunction as assessed by echocardiography.

Methods: We studied 200 consecutive subjects. LV systolic dysfunction has been determined to be present when the LV ejection fraction was < 50%. Read More

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https://www.karger.com/Article/FullText/494066
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http://dx.doi.org/10.1159/000494066DOI Listing
November 2018
11 Reads

Pregnancy-Induced Physiologic Adaptation of the Abdominal Aorta Is Associated with Changes in Gene Expression and Genomic Methylation.

J Vasc Res 2018 22;55(5):319-327. Epub 2018 Oct 22.

Background/aims: Ten-eleven translocation 2 (Tet2), a DNA demethylase enzyme, has been identified as a master epigenetic regulator of vascular smooth muscle cell plasticity. We hypothesized that pregnancy will induce significant adaptive changes in aortic biomechanics that correlate with the Tet family gene expression.

Methods: Abdominal aortas from pregnant and nonpregnant mice were dissected and cannulated. Read More

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https://www.karger.com/Article/FullText/493682
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http://dx.doi.org/10.1159/000493682DOI Listing
October 2018
2 Reads

Association between Atrial Fibrillation and Aortic Aneurysms: A Population-Based Cohort Study.

J Vasc Res 2018 22;55(5):299-307. Epub 2018 Oct 22.

Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei,

Objective: Atrial fibrillation (AF) is the most common form of sustained arrhythmia. Several molecular pathways associated with the pathogenesis of AF also participate in the initiation and progression of aortic aneurysm (AA). In this study, we aimed to evaluate potential associations between AA and AF. Read More

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https://www.karger.com/Article/FullText/493692
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http://dx.doi.org/10.1159/000493692DOI Listing
October 2018
13 Reads

Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina.

J Vasc Res 2018 22;55(5):308-318. Epub 2018 Oct 22.

Center for Cardiovascular Research, Columbus, Ohio,

Loss of vascular pericytes has long been associated with the onset of diabetic retinopathy; however, mechanisms contributing to pericyte dropout are not understood. Notch3 has been implicated in pericyte stability and survival, and linked to vascular integrity. Notch3 mutant mice exhibit progressive loss of retinal pericytes. Read More

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https://www.karger.com/Article/FullText/493151
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http://dx.doi.org/10.1159/000493151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280662PMC
October 2018
11 Reads

Histological and Mechanical Assessment of Decellularized Porcine Biografts, and Its Biological Evaluation following Aortic Implantation during Mid-Term Follow-Up.

J Vasc Res 2018 19;55(5):287-298. Epub 2018 Sep 19.

Department of Vascular Surgery, Medical School, University of PĂ©cs, PĂ©cs, Hungary.

Aims: Prosthetic graft infection frequently requires graft replacement. Among other options, a biological graft could serve as an alternative choice. Decellularization reduces tissue immunogenicity. Read More

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https://www.karger.com/Article/FullText/491929
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http://dx.doi.org/10.1159/000491929DOI Listing
September 2018
4 Reads

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease.

J Vasc Res 2018 17;55(4):244-254. Epub 2018 Sep 17.

Department of Physiology, Defence Institute of Physiology & Allied Sciences, Timarpur, New Delhi, India.

High mobility group box 1 protein (HMGB1), a sterile inflammatory molecule and damage-associated molecular pattern (DAMP) released from various cells during stress has been implicated in inflammation. Several reports show that there is a direct relationship between inflammation and cardiovascular diseases (CVDs) such as thrombosis, hypertension, insulin resistance, preeclampsia, etc. Here, we intend to summarize the concept of the emerging link between HMGB1 and CVDs. Read More

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http://dx.doi.org/10.1159/000491390DOI Listing
September 2018

Intussusceptive Pillar Formation in Developing Porcine Glomeruli.

J Vasc Res 2018 13;55(5):278-286. Epub 2018 Sep 13.

Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke,

Background/aims: Intussusceptive angiogenesis (IA) is a dynamic process which contributes to vascular expansion and remodeling. Intraluminal pillars have long been the distinctive structural indicator of IA. However, the mechanism of their formation has not been fully elucidated. Read More

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http://dx.doi.org/10.1159/000490905DOI Listing
September 2018
1 Read

Carotid-Jugular Fistula Model to Study Systemic Effects and Fistula-Related Microcirculatory Changes.

J Vasc Res 2018 10;55(5):268-277. Epub 2018 Sep 10.

Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen,

Background: Arteriovenous fistulae impair the distal circulation, but their effects at the microcirculatory level are not well understood. This study presents the carotid-jugular fistula (CJF) as a model to evaluate fistula-related microcirculatory and systemic changes.

Materials And Methods: Female Wistar rats were anesthetized and divided into a fistula group (FG, n = 10) and a sham group (SG, n = 6). Read More

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http://dx.doi.org/10.1159/000491930DOI Listing
September 2018
17 Reads

Perfusion Tissue Culture Initiates Differential Remodeling of Internal Thoracic Arteries, Radial Arteries, and Saphenous Veins.

J Vasc Res 2018 4;55(5):255-267. Epub 2018 Sep 4.

Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, South Carolina,

Adaptive remodeling processes are essential to the maintenance and viability of coronary artery bypass grafts where clinical outcomes depend strongly on the tissue source. In this investigation, we utilized an ex vivo perfusion bioreactor to culture porcine analogs of common human bypass grafts: the internal thoracic artery (ITA), the radial artery (RA), and the great saphenous vein (GSV), and then evaluated samples acutely (6 h) and chronically (7 days) under in situ or coronary-like perfusion conditions. Although morphologically similar, primary cells harvested from the ITA illustrated lower intimal and medial, but not adventitial, cell proliferation rates than those from the RA or GSV. Read More

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http://dx.doi.org/10.1159/000492484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230500PMC
September 2018
3 Reads
2.901 Impact Factor

Obstructive Sleep Apnoea and Aortic Aneurysm: A Nationwide Population-Based Retrospective Study.

J Vasc Res 2018 22;55(4):235-243. Epub 2018 Aug 22.

Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Objective: To determine whether patients with obstructive sleep apnoea (OSA) have an increased risk of aortic aneurysm (AA).

Methods: The data for the nationwide population-based retrospective cohort study described here were obtained from the Taiwan National Health Insurance Research Database (NHIRD). We selected adult patients who had been newly diagnosed as having OSA and were followed up between 2000 and 2010. Read More

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https://www.karger.com/Article/FullText/491928
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http://dx.doi.org/10.1159/000491928DOI Listing
August 2018
15 Reads

Thyroid Hormone Receptor Alpha Deletion in ApoE-/- Mice Alters the Arterial Renin-Angiotensin System and Vascular Smooth Muscular Cell Cholesterol Metabolism.

J Vasc Res 2018 9;55(4):224-234. Epub 2018 Aug 9.

Platform ANIPHY, University Lyon 1, Lyon, France.

Thyroid hormone (TH) regulates gene transcription by binding to TH receptors (TRs). TRs regulate the genes of lipid metabolism and the renin-angiotensin system (RAS). We examined the effect of TRα deletion in ApoE-/- mice (DKO mice) on the following: (i) the expression of genes controlling cholesterol metabolism and tissue (t)RAS in the liver and aorta and (ii) the expression of these genes and the regulation of cholesterol content in cultured vascular smooth muscle cells (VSMCs). Read More

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http://dx.doi.org/10.1159/000491430DOI Listing
August 2018
5 Reads

Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging.

J Vasc Res 2018 2;55(4):210-223. Epub 2018 Aug 2.

Age-associated structural and functional remodeling of the arterial wall produces a productive environment for the initiation and progression of hypertension and atherosclerosis. Chronic aging stress induces low-grade proinflammatory signaling and causes cellular proinflammation in arterial walls, which triggers the structural phenotypic shifts characterized by endothelial dysfunction, diffuse intimal-medial thickening, and arterial stiffening. Microscopically, aged arteries exhibit an increase in arterial cell senescence, proliferation, invasion, matrix deposition, elastin fragmentation, calcification, and amyloidosis. Read More

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http://dx.doi.org/10.1159/000490244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174095PMC
August 2018
2 Reads

Effects of Selenium in the Microcirculation of Fructose-Fed Hamsters.

J Vasc Res 2018 12;55(4):203-209. Epub 2018 Jul 12.

Background And Aims: Fructose intake is directly related to vascular dysfunction and it is a risk factor for the development of metabolic and cardiovascular diseases, such as obesity, diabetes, and hypertension. Selenium, a component of antioxidant enzymes, improves hyperglycemia and vascular function in diabetic animals. The aim of this study was to evaluate the effects of dietary selenium supplementation on microcirculatory and metabolic parameters of fructose-fed hamsters. Read More

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http://dx.doi.org/10.1159/000489957DOI Listing
July 2018
16 Reads

No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss.

J Vasc Res 2018 11;55(4):189-202. Epub 2018 Jul 11.

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Background: Aging, obesity, and diabetes favor vascular dysfunction. Endothelial activation of adenosine monophosphate-activated protein kinase (AMPK) has protective effects in diabetes.

Methods: Mice with constitutive endothelial activation of AMPK (CA-AMPK) were given a high fat diet to induce obesity or kept on standard chow as lean controls for up to 2 years. Read More

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http://dx.doi.org/10.1159/000489959DOI Listing
July 2018
7 Reads

A Simple Method for Normalization of Aortic Contractility.

J Vasc Res 2018 5;55(3):177-186. Epub 2018 Jul 5.

Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA.

Vascular contractile function changes in proliferative vascular diseases, e.g. atherosclerosis, and is documented using isolated blood vessels; yet, many laboratories differ in their approach to quantification. Read More

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http://dx.doi.org/10.1159/000490245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054883PMC
August 2018
1 Read

Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells.

J Vasc Res 2018 4;55(3):169-176. Epub 2018 Jul 4.

Coronary heart disease (CHD) remains a major public health burden. Endothelial-dependent coronary artery vasoreactivity is a significant indicator of vascular function. Endothelial dysfunction is characterized by decreased nitric oxide (NO) bioavailability and predicts late cardiovascular events. Read More

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http://dx.doi.org/10.1159/000489958DOI Listing
August 2018
1 Read

β-Adrenoceptor Blockade for Infantile Hemangioma Therapy: Do β3-Adrenoceptors Play a Role?

J Vasc Res 2018 22;55(3):159-168. Epub 2018 Jun 22.

Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.

Infantile hemangiomas (IH) are frequent (4-5% of the childhood population) benign vascular tumors that involve accumulation, proliferation, and differentiation of aberrant vascular cells. Typically, IH are innocuous and spontaneously disappear, but they represent a potential risk for harmful effects in the body (e.g. Read More

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http://dx.doi.org/10.1159/000489956DOI Listing

Differential Stiffening between the Abdominal and Thoracic Aorta: Effect of Salt Loading in Stroke-Prone Hypertensive Rats.

J Vasc Res 2018 8;55(3):144-158. Epub 2018 Jun 8.

Cardiovascular Discovery Research Unit Suresnes, Servier Research Institute, Suresnes, France.

Central artery stiffening is recognized as a cardiovascular risk. The effects of hypertension and aging have been shown in human and animal models but the effect of salt is still controversial. We studied the effect of a high-salt diet on aortic stiffness in salt-sensitive spontaneously hypersensitive stroke-prone rats (SHRSP). Read More

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https://www.karger.com/Article/FullText/488877
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http://dx.doi.org/10.1159/000488877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106143PMC
August 2018
5 Reads

A Novel ex vivo Mouse Mesometrium Culture Model for Investigating Angiogenesis in Microvascular Networks.

J Vasc Res 2018 18;55(3):125-135. Epub 2018 May 18.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA.

Background: The development of models that incorporate intact microvascular networks enables the investigation of multicellular dynamics during angiogenesis. Our laboratory introduced the rat mesentery culture model as such a tool, which would be enhanced with mouse tissue. Since mouse mesentery is avascular, an alternative is mouse mesometrium, the connective tissue of uterine horns. Read More

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https://www.karger.com/Article/FullText/489102
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http://dx.doi.org/10.1159/000489102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314041PMC
August 2018
3 Reads

Intraoperative Incident Dark Field Imaging of the Human Peritoneal Microcirculation.

J Vasc Res 2018 18;55(3):136-143. Epub 2018 May 18.

Department of Surgery, Academic Medical Center, Amsterdam, the Netherlands.

Background/aims: This study describes the peritoneal microcirculation, compares quantitative parameters and angioarchitecture to the standard of sublingual microcirculatory assessment, and determines the practical feasibility of this method.

Methods: Incident dark field imaging was performed of the peritoneum and sublingually to determine angioarchitecture, total and perfused vessel density (TVD and PVD), the proportion of perfused vessels (PPV), the microvascular flow index (MFI) and image acquisition time.

Results: Peritoneal angioarchitecture was characterized by a quadrangular network of longitudinally oriented capillaries, often flanked by fat cells. Read More

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http://dx.doi.org/10.1159/000488392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106141PMC
August 2018
4 Reads

RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain.

J Vasc Res 2018 10;55(2):111-123. Epub 2018 Apr 10.

School of Biotechnology, Dublin City University, Dublin, Ireland.

Receptor activator of nuclear factor-ÎşB ligand (RANKL) promotes vascular calcification, while osteoprotegerin (OPG) opposes it by blocking RANKL activity. It remains unclear which vascular cell populations produce and secrete OPG/RANKL. This study characterizes the production of OPG/RANKL from human aortic endothelial and smooth muscle cells (HAECs and HASMCs) under various conditions. Read More

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http://dx.doi.org/10.1159/000486787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375687PMC
July 2018
4 Reads

Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.

J Vasc Res 2018 16;55(2):98-110. Epub 2018 Feb 16.

Department of Cellular Biology and Anatomy, School of Medicine, Shreveport, Louisiana, USA.

Background: Mitochondrial reactive oxygen species (ROS) contribute to inflammation and vascular remodeling during atherosclerotic plaque formation. C57BL/6N (6N) and C57BL/6J (6J) mice display distinct mitochondrial redox balance due to the absence of nicotinamide nucleotide transhydrogenase (NNT) in 6J mice. We hypothesize that differential NNT expression between these animals alters plaque development. Read More

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http://dx.doi.org/10.1159/000486337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287760PMC
July 2018
7 Reads

Remodeling of Wall Mechanics and the Myogenic Mechanism of Rat Intramural Coronary Arterioles in Response to a Short-Term Daily Exercise Program: Role of Endothelial Factors.

J Vasc Res 2018 14;55(2):87-97. Epub 2018 Feb 14.

Department of Pathophysiology, Semmelweis University, Budapest, Hungary.

Purpose: Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure.

Methods: Male rats were subjected to a progressively increasing 4-week treadmill exercise program (over 60 min/day, 1 mph in the final step). Read More

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https://www.karger.com/Article/FullText/486571
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http://dx.doi.org/10.1159/000486571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970044PMC
July 2018
3 Reads

Ligand-Activated Peroxisome Proliferator-Activated Receptor δ Attenuates Vascular Oxidative Stress by Inhibiting Thrombospondin-1 Expression.

J Vasc Res 2018 6;55(2):75-86. Epub 2018 Feb 6.

Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea.

Thrombospondin-1 (TSP-1) is implicated in vascular diseases associated with oxidative stress, such as abdominal aortic aneurysms, ischemia-reperfusion injury, and atherosclerosis. However, the regulatory mechanisms underlying TSP-1 expression are not fully elucidated. In this study, we found that peroxisome proliferator-activated receptor δ (PPARδ) inhibited oxidative stress-induced TSP-1 expression and migration in vascular smooth muscle cells (VSMCs). Read More

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http://dx.doi.org/10.1159/000486570DOI Listing
July 2018
11 Reads

The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model.

J Vasc Res 2018 29;55(2):63-74. Epub 2018 Jan 29.

Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, Nara City, Japan.

Abdominal aortic aneurysm (AAA) is a vascular disease characterized by chronic inflammation in the infrarenal aorta. Most cases of AAA remain asymptomatic until rupture, and the mortality rate of patients with AAA rupture is very high. Currently, the relation between dietary habits and AAA development remains unknown. Read More

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http://dx.doi.org/10.1159/000481780DOI Listing
July 2018
6 Reads

Cooperative Effects of Q10, Vitamin D3, and L-Arginine on Cardiac and Endothelial Cells.

J Vasc Res 2018 5;55(1):47-60. Epub 2018 Jan 5.

Laboratory of Physiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

This work demonstrates the cooperative effect of Q10, vitamin D3, and L-arginine on both cardiac and endothelial cells. The effects of Q10, L-arginine, and vitamin D3 alone or combined on cell viability, nitric oxide, and reactive oxygen species productions in endothelial and cardiac cells were studied. Moreover, the involvement of PI3K/Akt and ERK/MAPK pathways leading to eNOS activation as well as the involvement of vitamin D receptor were also investigated. Read More

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http://dx.doi.org/10.1159/000484928DOI Listing
June 2018
2 Reads

Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease.

J Vasc Res 2018 13;55(1):35-46. Epub 2017 Dec 13.

Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK.

Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (≥5 cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage aneurysm. Read More

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https://www.karger.com/Article/FullText/484088
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http://dx.doi.org/10.1159/000484088DOI Listing
June 2018
15 Reads

Perturbations in Endothelial Dysfunction-Associated Pathways in the Nitrofen-Induced Congenital Diaphragmatic Hernia Model.

J Vasc Res 2018 8;55(1):26-34. Epub 2017 Dec 8.

Department of Pediatric Surgery, University of Texas McGovern Medical School, Houston, TX, USA.

Although it is well known that nitrofen induces congenital diaphragmatic hernia (CDH), including CDH-associated lung hypoplasia and pulmonary hypertension (PH) in rodents, the mechanism of pathogenesis remains largely unclear. It has been reported that pulmonary artery (PA) endothelial cell (EC) dysfunction contributes to the development of PH in CDH. Thus, we hypothesized that there is significant alteration of endothelial dysfunction-associated proteins in nitrofen-induced CDH PAs. Read More

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https://www.karger.com/Article/FullText/484087
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http://dx.doi.org/10.1159/000484087DOI Listing
June 2018
14 Reads

Comparative Anti-Platelet Profiling Reveals a Potent Anti-Aggregatory Effect of CD34+ Progenitor Cell-Derived Late-Outgrowth Endothelial Cells in vitro.

J Vasc Res 2018 2;55(1):13-25. Epub 2017 Dec 2.

Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, School of Medicine, University of Ioannina, Ioannina, Greece.

Background/aims: Platelets affect endothelial progenitor cell (EPC) functionality, inducing their differentiation into mature endothelial cells. However, it remains to be established whether EPCs can influence platelet functionality.

Methods: Mononuclear proangiogenic cells (MPCs) and early outgrowth cells (EOCs) were prepared from peripheral blood mononuclear cells, whereas late-outgrowth endothelial cells (OECs) were prepared from cord blood CD34+ cells. Read More

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http://dx.doi.org/10.1159/000481779DOI Listing
June 2018
17 Reads
2.901 Impact Factor

Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats.

J Vasc Res 2018 23;55(1):1-12. Epub 2017 Nov 23.

Weldon School of Biomedical Engineering, West Lafayette, IN, USA.

The apolipoprotein E-deficient (apoE-/-) mouse model has advanced our understanding of cardiovascular disease mechanisms and experimental therapeutics. This spontaneous model recapitulates aspects of human atherosclerosis, and allows for the development of dissecting abdominal aortic aneurysms (AAAs) when combined with angiotensin II. We characterized apoE-/- rats and hypothesized that, similar to mice, they would develop dissecting AAAs. Read More

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http://dx.doi.org/10.1159/000484086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829005PMC
June 2018
5 Reads

Effect of Calcium-Infiltrated Hydroxyapatite Scaffolds on the Hematopoietic Fate of Human Umbilical Vein Endothelial Cells.

J Vasc Res 2017 23;54(6):376-385. Epub 2017 Nov 23.

Department of Mechanical Engineering and Materials Science, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Foamed hydroxyapatite offers a three-dimensional scaffold for the development of bone constructs, mimicking perfectly the in vivo bone structure. In vivo, calcium release at the surface is assumed to provide a locally increased gradient supporting the maintenance of the hematopoietic stem cells niche. We fabricated hydroxyapatite scaffolds with high surface calcium concentration by infiltration, and used human umbilical vein endothelial cells (HUVECs) as a model to study the effects on hematopoietic lineage direction. Read More

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http://dx.doi.org/10.1159/000481778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720900PMC
December 2017
2 Reads

Toll-Like Receptor 4 Reduces Occludin and Zonula Occludens 1 to Increase Retinal Permeability Both in vitro and in vivo.

J Vasc Res 2017 15;54(6):367-375. Epub 2017 Nov 15.

Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA.

We reported that β-adrenergic receptors regulate toll-like receptor 4 (TLR4) signaling in the retina of diabetic mice and in retinal endothelial cells (REC) and Müller cells. We hypothesized that TLR4 regulates retinal permeability both in vitro and in vivo in the retinal vasculature. We used REC cultured in normal and high-glucose conditions and TLR4 siRNA treatments for cell culture studies of permeability and protein analyses of tumor necrosis factor α, occludin, and zonula occludens 1 (ZO-1). Read More

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http://dx.doi.org/10.1159/000480455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896294PMC
December 2017
20 Reads

Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice.

J Vasc Res 2017 9;54(6):359-366. Epub 2017 Nov 9.

Department of Anatomy, MTA-PTE PACAP Research Group, Medical School, University of Pecs, Pecs, Hungary.

Pituitary adenylate cyclase-activating peptide (PACAP; 1-38 and 1-27) and vasoactive intestinal peptide (VIP) are related neuropeptides of the secretin/glucagon family. Overlapping signaling through G-protein-coupled receptors mediates their vasomotor activity. We previously showed that PACAP deficiency (PACAP-KO) shifts the mechanisms of vascular response and maintains arterial relaxation through the VIP backup mechanism and (mainly) its VPAC1R, but their age-dependent modulation is still unknown. Read More

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http://dx.doi.org/10.1159/000481781DOI Listing
December 2017
5 Reads

Low-Frequency Components in Rat Pial Arteriolar Rhythmic Diameter Changes.

J Vasc Res 2017 25;54(6):344-358. Epub 2017 Oct 25.

Department of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.

This study aimed to analyze the frequency components present in spontaneous rhythmic diameter changes in rat pial arterioles. Pial microcirculation was visualized by fluorescence microscopy. Rhythmic luminal variations were evaluated via computer-assisted methods. Read More

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http://dx.doi.org/10.1159/000478984DOI Listing
December 2017
4 Reads

Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats.

J Vasc Res 2017 18;54(6):329-343. Epub 2017 Oct 18.

Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Aim: The objective of this study was to examine the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on coronary arterial large conductance Ca2+-activated K+ (BK) channel function in coronary smooth muscle cells (SMCs) of streptozotocin-induced diabetic rats.

Methods: The effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on coronary BK channel open probabilities were determined using the patch clamp technique. The mRNA and protein expressions of BK channel subunits were measured using qRT-PCR and Western blots. Read More

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http://dx.doi.org/10.1159/000479870DOI Listing
December 2017
22 Reads

Overexpression of Insulin-Like Growth Factor-2 in Expanded Endothelial Progenitor Cells Improves Left Ventricular Function in Experimental Myocardial Infarction.

J Vasc Res 2017 27;54(6):321-328. Epub 2017 Sep 27.

Deutsches Herzzentrum, Technischen Universität München, Munich, Germany.

Insulin-like growth factors (IGFs) are mediators of growth hormone-induced metabolic and anabolic actions, but also regulate cell growth, differentiation, and apoptosis and show beneficial effects in acute myocardial ischemia. Since endothelial progenitor cells (EPCs) improve myocardial function after acute myocardial infarction, we sought to investigate whether overexpression of IGF-2 in expanded EPCs (eEPCs) further contributes to improvement in left ventricular function after myocardial infarction. EPCs were isolated from human cord blood and transduced by a retroviral vector expression of IGF-2 (IGF-2 eEPCs) or vector only. Read More

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http://dx.doi.org/10.1159/000479872DOI Listing
December 2017
11 Reads

Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease: The iPOWER Study.

J Vasc Res 2017 23;54(5):309-319. Epub 2017 Sep 23.

Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark.

Purpose: We investigated whether impaired flow-mediated dilation (FMD) and plasma biomarkers reflecting endothelial dysfunction are associated with coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease (CAD).

Methods: Patients (n = 194) were randomly selected women with angina pectoris and no obstructive CAD (<50% stenosis). A reference population of asymptomatic women without CAD (n = 25) was included. Read More

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http://dx.doi.org/10.1159/000479374DOI Listing
October 2017
22 Reads

Epigallocatechin-3-Gallate Ameliorates Angiotensin II-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells through the Activation of Nrf2/Caspase-3 Signaling.

J Vasc Res 2017 23;54(5):299-308. Epub 2017 Sep 23.

Department of Cardiology, The First People's Hospital of Yunnan, Kunming, China.

Introduction: This study aimed to investigate whether epigallocatechin-3-gallate (EGCG) shows antioxidant activity against angiotensin II (Ang II)-induced human umbilical vein endothelial cell (HUVEC) apoptosis.

Materials And Methods: The viability of HUVECs was revealed by MTT and LDH assay. The cell apoptosis was detected by FITC-PI assay. Read More

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https://www.karger.com/Article/FullText/479873
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http://dx.doi.org/10.1159/000479873DOI Listing
October 2017
6 Reads

VEGF and IGF Delivered from Alginate Hydrogels Promote Stable Perfusion Recovery in Ischemic Hind Limbs of Aged Mice and Young Rabbits.

J Vasc Res 2017 21;54(5):288-298. Epub 2017 Sep 21.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.

Biomaterial-based delivery of angiogenic growth factors restores perfusion more effectively than bolus delivery methods in rodent models of peripheral vascular disease, but the same success has not yet been demonstrated in clinically relevant studies of aged or large animals. These studies explore, in clinically relevant models, a therapeutic angiogenesis strategy for the treatment of peripheral vascular disease that overcomes the challenges encountered in previous clinical trials. Alginate hydrogels providing sustained release of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF) were injected into ischemic hind limbs in middle-aged and old mice, and also in young rabbits, as a test of the scalability of this local growth factor treatment. Read More

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http://dx.doi.org/10.1159/000479869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642984PMC
October 2017
16 Reads

Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice.

J Vasc Res 2017 21;54(5):280-287. Epub 2017 Sep 21.

Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.

Background/aims: Endoplasmic reticulum (ER) stress has emerged as a potential mechanism contributing to diabetes and its comorbidities. However, the importance of ER stress in diabetic vascular dysfunction is unclear. The purpose of this study was to examine the effects of the ER stress inhibitor, tauroursodeoxycholic acid (TUDCA), on arterial stiffness and endothelial dysfunction in type 2 diabetic mice. Read More

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http://dx.doi.org/10.1159/000479967DOI Listing
October 2017
9 Reads

Impact of Age and Aerobic Exercise Training on Conduit Artery Wall Thickness: Role of the Shear Pattern.

J Vasc Res 2017 15;54(5):272-279. Epub 2017 Sep 15.

Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

Hemodynamic shear stress is the frictional force of blood on the arterial wall. The shear pattern in the conduit artery affects the endothelium and may participate in the development and progression of atherosclerosis. We investigated the role of the shear pattern in age- and aerobic exercise-induced changes in conduit artery wall thickness via cross-sectional and interventional studies. Read More

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http://dx.doi.org/10.1159/000479871DOI Listing
October 2017
25 Reads