2,030 results match your criteria Journal of toxicology[Journal]


Hepatic and Renal Toxicity Induced by TiO Nanoparticles in Rats: A Morphological and Metabonomic Study.

J Toxicol 2019 3;2019:5767012. Epub 2019 Mar 3.

Laboratory of Histology, University of Mons, Institute for Health Sciences and Technology, Faculty of Medicine and Pharmacy, 23 Place du Parc, 7000 Mons, Belgium.

Titanium dioxide (TiO) nanoparticles (NPs) are produced abundantly and are frequently used as a white pigment in the manufacture of paints, foods, paper, and toothpaste. Despite the wide ranges of uses, there is a lack of information on the impact of NPs on animal and human health. In the present study, rats were exposed to different doses of TiO nanoparticles and sacrificed, respectively, 4 days, 1 month, and 2 months after treatment. Read More

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https://www.hindawi.com/journals/jt/2019/5767012/
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http://dx.doi.org/10.1155/2019/5767012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421043PMC
March 2019
1 Read

Bio Assay to Assess the Water and Sediment Cytogenotoxicity in a Tropical Stream Subjected to Multiple Point and Nonpoint Source Pollutants.

J Toxicol 2019 3;2019:5420124. Epub 2019 Mar 3.

Department of Zoology and Environmental Management, University of Kelaniya, Kelaniya, Sri Lanka.

The present study was conducted to assess the cytotoxicity of water and sediments of an industrial effluent receiving water body in the western province of Sri Lanka using bioassay. Six sampling sites (Site A: Urban; B: Industrial; C: Water intake for public water supply; D: Industrial; E: Agricultural; F: Reference) were selected from the study area. Ten replicate water and sediment samples were collected from each site, and physical and chemical parameters were measured using standard analytical methods. Read More

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http://dx.doi.org/10.1155/2019/5420124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421030PMC
March 2019
1 Read

Assessment of Phytoremediation Potential of to Treat Toxic Pollutants of Textile Effluent.

J Toxicol 2019 3;2019:8351272. Epub 2019 Feb 3.

Department of Applied Sciences, Chitkara University, Rajpura 140401, India.

Textile effluent released into water bodies is prone to be toxic for aquatic flora and fauna. In the present study, the phytoremediation potential of ( is investigated for treatment of textile effluent. The highly concentrated and toxic textile effluent is diluted to different concentrations 10%, 25%, 50%, and 75% to check the accessibility of macroalgae to bear pollutant load of textile effluent. Read More

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http://dx.doi.org/10.1155/2019/8351272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377995PMC
February 2019
1 Read

Phytochemical Screening and Toxicological Study of Linn Roots: Histopathological and Biochemical Evidence.

J Toxicol 2019 3;2019:8203832. Epub 2019 Feb 3.

Laboratory of Chemistry-Biochemistry, Environment, Nutrition, and Health, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, 19 rue Tarik Ibn Ziad, Casablanca, Morocco.

(A) is a wild species of Aristolochiaceae family; its roots are used by Moroccan people against cancer for many years ago. The objective of the study was to investigate the phytochemical screening, acute and subacute toxicity of roots growing in the north of Morocco. Qualitative and quantitative analyses of roots were performed using standard methods; the acute toxicity of the root extract of the studied plant was assessed in mice by gavage of single doses of 1, 2, and 4 g/kg body weight for 14 days; by the time the subacute toxicity was done using repeated doses 1, 1. Read More

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http://dx.doi.org/10.1155/2019/8203832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377958PMC
February 2019
1 Read

Evaluation of Skin Irritation and Acute and Subacute Oral Toxicity of Essential Oils in Rabbit and Mice.

J Toxicol 2019 27;2019:5979546. Epub 2019 Jan 27.

Plant Biology and Biodiversity Management Department, College of Computational Sciences and Natural, Addis Ababa University, Private P.O. Box 34731, Addis Ababa, Ethiopia.

is used in traditional and folk medicines of Ankober District, North Central Ethiopia, for the treatment of several livestock and human disorders. This toxicity study aimed to investigate essential oil oral toxicity in mice and skin irritation in rabbit. essential oil was analyzed using gas chromatography-mass spectrometry methods and showed predominance of Eucalyptol (52. Read More

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http://dx.doi.org/10.1155/2019/5979546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369505PMC
January 2019

Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund's Adjuvant-Induced Arthritis Model in Rats.

J Toxicol 2019 17;2019:7898914. Epub 2019 Jan 17.

Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of bark confirms the presence of flavonoids, polyphenols, and tannins. Read More

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http://dx.doi.org/10.1155/2019/7898914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354132PMC
January 2019
2 Reads

Histological, Genotoxic, and Biochemical Effects on (Jenyns 1842) (Cyprinodontiformes, Poeciliidae): Early Response Bioassays to Assess the Impact of Receiving Waters.

J Toxicol 2019 1;2019:4687685. Epub 2019 Jan 1.

Programa de Ecofisiología Aplicada (PRODEA), Instituto de Ecología y Desarrollo Sustentable (INEDES, CONICET-UNLU), Universidad Nacional de Luján (B6700ZBA), Luján, Argentina.

In the present study, the toxicity of receiving waters from a highly polluted urban watercourse, the Reconquista River, Argentina, collected at a dam in the upstream part of the river was evaluated. a widely distributed fish species in Pampasic rivers proposed for use in ecotoxicological evaluations, was used as a test organism. A 96-h acute toxicity bioassay with river water quality which has been characterized as moderately contaminated was performed. Read More

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http://dx.doi.org/10.1155/2019/4687685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332968PMC
January 2019
1 Read

Environmental Chemical Contaminants in Food: Review of a Global Problem.

J Toxicol 2019 1;2019:2345283. Epub 2019 Jan 1.

Laboratory of Advanced Lipid Analysis, Department of Health Sciences and Technology, Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Contamination by chemicals from the environment is a major global food safety issue, posing a serious threat to human health. These chemicals belong to many groups, including metals/metalloids, polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs), perfluorinated compounds (PFCs), pharmaceutical and personal care products (PPCPs), radioactive elements, electronic waste, plastics, and nanoparticles. Some of these occur naturally in the environment, whilst others are produced from anthropogenic sources. Read More

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http://dx.doi.org/10.1155/2019/2345283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332928PMC
January 2019
1 Read

Zebrafish Embryo Toxicity of a Binary Mixture of Pyrethroid Insecticides: d-Tetramethrin and Cyphenothrin.

J Toxicol 2018 26;2018:4182694. Epub 2018 Dec 26.

Department of Zoology, Faculty of Natural Sciences, The Open University of Sri Lanka, Nawala, Nugegoda, Sri Lanka.

Pesguard FG161™, a mixture of d-tetramethrin and cyphenothrin (1:3 ratio), is extensively used to achieve rapid control of adult dengue vector, during the disease outbreaks. Both d-tetramethrin and cyphenothrin are synthetic pyrethroids that are known to have adverse effects on non-mammalian organisms such as fish. The present study intended to use zebrafish embryo toxicity model to investigate the toxic effect of the above binary mixture on fish. Read More

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https://www.hindawi.com/journals/jt/2018/4182694/
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http://dx.doi.org/10.1155/2018/4182694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327251PMC
December 2018
21 Reads

A Review of Metal Exposure and Its Effects on Bone Health.

J Toxicol 2018 23;2018:4854152. Epub 2018 Dec 23.

Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Argentina.

The presence of metals in the environment is a matter of concern, since human activities are the major cause of pollution and metals can enter the food chain and bioaccumulate in hard and soft tissues/organs, which results in a long half-life of the metal in the body. Metal intoxication has a negative impact on human health and can alter different systems depending on metal type and concentration and duration of metal exposure. The present review focuses on the most common metals found in contaminated areas (cadmium, zinc, copper, nickel, mercury, chromium, lead, aluminum, titanium, and iron, as well as metalloid arsenic) and their effects on bone tissue. Read More

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http://dx.doi.org/10.1155/2018/4854152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323513PMC
December 2018
3 Reads

Toxicity Evaluation of a Novel Magnetic Resonance Imaging Marker, CoCl2-N-Acetylcysteine, in Rats.

J Toxicol 2018 2;2018:9173452. Epub 2018 Dec 2.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, USA.

C4 (cobalt dichloride-N-acetylcysteine [1% CoCl:2% NAC]) is a novel magnetic resonance imaging contrast marker that facilitates visualization of implanted radioactive seeds in cancer brachytherapy. We evaluated the toxicity of C4. Rats were assigned to control (0% CoCl:NAC), low-dose (0. Read More

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https://www.hindawi.com/journals/jt/2018/9173452/
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http://dx.doi.org/10.1155/2018/9173452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304599PMC
December 2018
18 Reads

The Pesticide Exposure of People Living in Agricultural Community, Northern Thailand.

J Toxicol 2018 29;2018:4168034. Epub 2018 Nov 29.

NCD Center of Excellence, Environment and Health Research Unit, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

Background And Aim: Biomarkers of pesticide exposure are generally lacking in communities where agricultural crops are grown. The purpose of this study was to focus on evaluating biomarkers of pesticide exposure in people living in an agricultural area of San Pa Tong District in Chiang Mai Province, northern Thailand.

Materials And Methods: One hundred and twenty-four participants (38 nonfarm workers, 38 rice growers, 31 longan growers, and 17 vegetable growers) from San Pa Tong District gave consent to participate in the study. Read More

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http://dx.doi.org/10.1155/2018/4168034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304500PMC
November 2018

Protective Effect of Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF- and TGF-1.

J Toxicol 2018 2;2018:2642714. Epub 2018 Dec 2.

Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Jakarta, Indonesia.

is one of the Indonesian herbal plants which has been shown to have a hepatoprotective effect. This study was conducted to evaluate the protective effect of water extract of mahkota dewa () in liver fibrosis and to elucidate its mechanism of action. Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl) for 8 weeks to induce liver fibrosis. Read More

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https://www.hindawi.com/journals/jt/2018/2642714/
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http://dx.doi.org/10.1155/2018/2642714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304574PMC
December 2018
15 Reads

Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine.

J Toxicol 2018 21;2018:8023840. Epub 2018 Nov 21.

Antomy and Embryology Department, Faculty of Medicine, Zagazig University, Egypt.

Objective: The aim of our study is to compare the role of the new natural alternative (Quercetin) with the current iron-chelation therapy (Deferoxamine (DFO)) in the effect of iron overload on small intestinal tissues and to investigate the possible underlying molecular mechanisms of such toxicity.

Methods: Forty-two adult male albino rats were divided into six groups: control groups, DFO, Quercetin, iron overload, iron overload+DFO, and iron overload+Quercetin groups. Animals received daily intraperitoneal injection of Deferoxamine (125 mg /kg), Quercetin (10 mg/kg), and ferric dextran (200 mg/kg) for 2 weeks. Read More

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http://dx.doi.org/10.1155/2018/8023840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280249PMC
November 2018
1 Read

Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF- and ERK 1/2 Pathways.

J Toxicol 2018 14;2018:5360496. Epub 2018 Nov 14.

Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Indonesia.

Liver fibrosis is characterized by excessive accumulation of extracellular matrix in chronic liver injury. Alcohol-induced fibrosis may develop into cirrhosis, one of the major causes of liver disease mortality. Previous studies have shown that alpha mangostin can decrease ratio of pSmad/Smad and pAkt/Akt in TGF--induced liver fibrosis model . Read More

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http://dx.doi.org/10.1155/2018/5360496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261236PMC
November 2018

Sublethal Effects of Ionic and Nanogold on the Nematode .

J Toxicol 2018 1;2018:6218193. Epub 2018 Nov 1.

Water Research Group, Unit for Environmental Sciences and Management, Potchefstroom Campus, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

The nematode is used as an ecotoxicological model species in both aqueous medium and solid substrates. It is easy and of low cost to maintain in the laboratory and it produces hundreds of offspring within a short period of time. It also has a small body size (1 mm), making it possible for assays to be conducted in 12-well plates. Read More

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http://dx.doi.org/10.1155/2018/6218193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236908PMC
November 2018

Risk Assessment of Kumasi Metropolis Population in Ghana through Consumption of Fish Contaminated with Formaldehyde.

J Toxicol 2018 1;2018:4785031. Epub 2018 Nov 1.

Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

This study evaluates the exposure of the Ghanaian population of the Kumasi Metropolis of Ghana to formaldehyde through the consumption of fish using 3-Methyl-2-Benzothiazoline Hydrazone method, with trichloroacetic acid as an extracting agent. A total of sixty (60) fish species comprising both local and imported fish were bought from cold stores and fish ponds were analysed. Formaldehyde was found in all the species analysed with concentration ranging from 0. Read More

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http://dx.doi.org/10.1155/2018/4785031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236555PMC
November 2018
1 Read

Assessment of Pharmaceuticals, Personal Care Products, and Hormones in Wastewater Treatment Plants Receiving Inflows from Health Facilities in North West Province, South Africa.

J Toxicol 2018 30;2018:3751930. Epub 2018 Oct 30.

Department of Environmental, Water and Earth Sciences, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.

The presence of 17 pharmaceutical and personal care products (PPCPs) belonging to various therapeutic categories was investigated in two hospital wastewater treatment plants (WWTPs) in North West Province, South Africa. The compounds were extracted from wastewater samples by solid-phase extraction and analysed by liquid chromatography-tandem mass spectrometry. The results showed that ofloxacin, chloramphenicol, and bezafibrate were generally below the limit of quantification (LOQ) in the analysed samples. Read More

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http://dx.doi.org/10.1155/2018/3751930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232802PMC
October 2018
1 Read

Quantitative Characterization of the Hemorrhagic, Necrotic, Coagulation-Altering Properties and Edema-Forming Effects of Zebra Snake () Venom.

J Toxicol 2018 24;2018:6940798. Epub 2018 Oct 24.

Department of Wildlife Management and Ecotourism, Katima Mulilo Campus, Faculty of Agriculture and Natural Resources, University of Namibia, P. Bag 1096, Ngweze, Katima Mulilo, Namibia.

This study was designed to investigate the cytotoxicity and haemotoxicity of the Western barred (zebra) spitting cobra () venom to help explain atypical and inconsistent reports on syndromes by Namibian physicians treating victims of human ophidian accidents. Freeze-dried venom milked from adult zebra snakes was dissolved in phosphate buffered saline (PBS) for use in this study. Haemorrhagic and necrotic activity of venom were studied in New Zealand albino rabbits. Read More

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https://www.hindawi.com/journals/jt/2018/6940798/
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http://dx.doi.org/10.1155/2018/6940798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220379PMC
October 2018
11 Reads

Biosorption of Cadmium by Filamentous Fungi Isolated from Coastal Water and Sediments.

J Toxicol 2018 22;2018:7170510. Epub 2018 Oct 22.

Department of Biological Sciences, Visayas State University, Visca, Baybay City, Leyte 6521-A, Philippines.

The use of microorganisms in decontaminating the environment encumbered with heavy metal pollutants through biosorption is considered as a good option for bioremediation. This study was conducted to isolate Cadmium (Cd) tolerant fungi from coastal waters and sediments, compare their biosorption capabilities, and identify the isolates with the highest Cd uptake. Water and sediment samples were collected near the effluent sites of industrial belt in Ibo, Lapu-lapu City, Cebu, Philippines. Read More

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https://www.hindawi.com/journals/jt/2018/7170510/
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http://dx.doi.org/10.1155/2018/7170510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217744PMC
October 2018
12 Reads

Role of Phytoremediation in Reducing Cadmium Toxicity in Soil and Water.

J Toxicol 2018 23;2018:4864365. Epub 2018 Oct 23.

Department of Applied Sciences, Chitkara University, Rajpura 140401, India.

Heavy metals are a noxious form of pollutants present in soil and water. A new plant-based solar energy driven technology, phytoremediation, emerges as eco-friendly and cost-effective approach to remove heavy metal from various media with the help of hyperaccumulating plant species. This review paper aims to provide information on phytoremediation and its mechanisms for heavy metal removal especially to focus on Cadmium (Cd) metal and highlights the role of various hyperaccumulating plants for Cd metal remediation in soil and water. Read More

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https://www.hindawi.com/journals/jt/2018/4864365/
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http://dx.doi.org/10.1155/2018/4864365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218723PMC
October 2018
17 Reads

Effect of Essential Oils from Ginger () and Turmeric () Rhizomes on Some Inflammatory Biomarkers in Cadmium Induced Neurotoxicity in Rats.

J Toxicol 2018 8;2018:4109491. Epub 2018 Oct 8.

Cell Biology and Neurotoxicity Unit, Department of Anatomy, College of Medicine and Health Sciences, Nigeria.

Studies have revealed that anti-inflammatory agents could provide beneficial effect in lowering the incidence/progression of neurological diseases. Hence, this study sought to investigate the effect of essential oils from Nigeria ginger and turmeric rhizomes on some cytokines in cadmium induced neurotoxicity. The result revealed that essential oil from ginger and turmeric rhizomes exerts anti-inflammatory effect by preventing alterations of some cytokines/inflammatory biomarkers (IL-6, IL-10 and TNF-Alpha) levels and inhibits both hippocampus and prefrontal cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities (important enzymes relevant in the management/prevention of neurodegenerative diseases) in Cd treated rats. Read More

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https://www.hindawi.com/journals/jt/2018/4109491/
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http://dx.doi.org/10.1155/2018/4109491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196928PMC
October 2018
1 Read

Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro.

J Toxicol 2018 1;2018:1367801. Epub 2018 Oct 1.

Department of Chemical and Materials Engineering, University of Dayton, Dayton, OH 45469, USA.

Due to their distinctive physicochemical properties, platinum nanoparticles (PtNPs) have emerged as a material of interest for a number of biomedical therapeutics. However, in some instances NP exposure has been correlated to health and safety concerns, including cytotoxicity, activation of cellular stress, and modification to normal cell functionality. As PtNPs have induced differential cellular responses , the goal of this study was to further characterize the behavior and toxicological potential of PtNPs within a HepG2 liver model. Read More

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https://www.hindawi.com/journals/jt/2018/1367801/
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http://dx.doi.org/10.1155/2018/1367801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188585PMC
October 2018
15 Reads

The Role of (L.) Merr. Leaf Powder in the Broiler Chickens Fed a Diet Naturally Contaminated with Aflatoxin.

J Toxicol 2018 1;2018:2069073. Epub 2018 Oct 1.

Undergraduate Student, Program of Medical Laboratory Technology, Faculty of Health, University of Muhammadiyah Sidoarjo, East Java, Indonesia.

Aflatoxin (AF) is the secondary metabolite of and commonly contaminates feed during storage. AF causes lowered growth rate, stress, and increased mortality in the poultry, especially for broiler industries. The aims of this study are to determine the effects of (L. Read More

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https://www.hindawi.com/journals/jt/2018/2069073/
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http://dx.doi.org/10.1155/2018/2069073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188729PMC
October 2018
10 Reads

The Venom of Spectacled Cobra (Elapidae: ): Study from Distinct Geographical Origins in Sri Lanka.

J Toxicol 2018 27;2018:7358472. Epub 2018 Sep 27.

Department of Veterinary Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka.

Several countries residing envenomation due to had revealed a disparity in the venom composition according to their geographic location and Sri Lankan cobra still lacks the evidence to support this. Therefore, the current study was focused on addressing relationship between the histopathological changes according to geographic variation of Sri Lankan venom. The histopathological changes in vital organs and muscle tissues following intramuscular administration of venom of were studied using BALB/c mice. Read More

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https://www.hindawi.com/journals/jt/2018/7358472/
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http://dx.doi.org/10.1155/2018/7358472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180993PMC
September 2018
13 Reads

Toxicity and Bioremediation of Heavy Metals Contaminated Ecosystem from Tannery Wastewater: A Review.

J Toxicol 2018 27;2018:2568038. Epub 2018 Sep 27.

Chemical and Biochemical Remediation Unit, Directorate of Research and Development, Nigerian Institute of Leather and Science Technology, Zaria 810001, Kaduna State, Nigeria.

The discharge of untreated tannery wastewater containing biotoxic substances of heavy metals in the ecosystem is one of the most important environmental and health challenges in our society. Hence, there is a growing need for the development of novel, efficient, eco-friendly, and cost-effective approach for the remediation of inorganic metals (Cr, Hg, Cd, and Pb) released into the environment and to safeguard the ecosystem. In this regard, recent advances in microbes-base heavy metal have propelled bioremediation as a prospective alternative to conventional techniques. Read More

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http://dx.doi.org/10.1155/2018/2568038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180975PMC
September 2018
14 Reads

The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission.

J Toxicol 2018 17;2018:7252606. Epub 2018 Sep 17.

Research Unit of Cerebral Monitoring in Neuro-Reanimation, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.

Purpose: The aim of this study is to investigate the possible role of heavy metals (lead and cadmium) and imbalance of trace elements (chromium, iron, zinc, copper, and manganese) in death among patients with severe traumatic brain injury.

Material And Methods: A case-control study was conducted with 64 comatose patients with severe TBI, in the Department of Anesthesiology and Reanimation, Ibn Sina University Hospital and Hospital of Specialties in Rabat, Morocco; 22 healthy volunteers were recruited in Blood Transfusion Center of Rabat. Blood samples were collected from TBI patients, in the first week (3h after admission and each 48h during one week) and from healthy volunteers one time. Read More

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https://www.hindawi.com/journals/jt/2018/7252606/
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http://dx.doi.org/10.1155/2018/7252606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166378PMC
September 2018
1 Read

The Application of a Macroinvertebrate Indicator in Afrotropical Regions for Pesticide Pollution.

J Toxicol 2018 12;2018:2581930. Epub 2018 Sep 12.

Water Research Group, Unit for Environmental Sciences and Management, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.

Many biotic integrity indices are not able to isolate community effects due to pesticide exposure as the communities also respond to other anthropogenic and natural stressors. A macroinvertebrate trait bioindicator system that is pesticide specific was therefore developed to overcome these challenges. This system, called SPEAR (SPEcies At Risk), was applied in South Africa as an indicator to link known pesticide catchment usage to changes in the macroinvertebrate community, especially when analytical methods are inconclusive. Read More

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http://dx.doi.org/10.1155/2018/2581930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157111PMC
September 2018

An Investigation into Tetrodotoxin (TTX) Levels Associated with the Red Dorsal Spots in Eastern Newt () Efts and Adults.

J Toxicol 2018 2;2018:9196865. Epub 2018 Sep 2.

Department of Biology, Hanover College, 517 Ball Drive, Hanover, IN 47243, USA.

We investigated the concentration of tetrodotoxin (TTX) in sections of skin containing and lacking red dorsal spots in both Eastern newt () efts and adults. Several other species, such as and have granular glands concentrated in brightly pigmented regions on the dorsum, and thus we hypothesized that the red dorsal spots of Eastern newts may also possess higher levels of TTX than the surrounding skin. We found no difference between the concentrations of TTX in the red spots as compared to neighboring skin lacking these spots in either efts or adults. Read More

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http://dx.doi.org/10.1155/2018/9196865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139183PMC
September 2018

An Appraisal of Pumpkin Seed Extract in 1, 2-Dimethylhydrazine Induced Colon Cancer in Wistar Rats.

J Toxicol 2018 2;2018:6086490. Epub 2018 Sep 2.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Background: Cancer is one of the most important public health burdens in developed and developing countries. Colon cancer (CC) is the sixth most common cause of death in India and third most important cause in developed countries. For treating cancer, several synthetic agents are available but they cause side effects. Read More

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http://dx.doi.org/10.1155/2018/6086490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139218PMC
September 2018

MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo.

J Toxicol 2018 28;2018:8460490. Epub 2018 Aug 28.

Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, UFSC, Campus Universitário, Trindade, Florianópolis, SC 88040-900, Brazil.

Methylmercury (MeHg) is a known neurodevelopmental toxicant, which causes changes in various structures of the central nervous system (CNS). However, ultrastructural studies of its effects on the developing CNS are still scarce. Here, we investigated the effect of MeHg on the ultrastructure of the cells in spinal cord layers. Read More

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http://dx.doi.org/10.1155/2018/8460490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136469PMC

Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells.

J Toxicol 2018 23;2018:4671326. Epub 2018 Aug 23.

Department of Cell Biology and Genetics, University of Lagos, Nigeria.

Artemisinin-based combination therapy is used to treat uncomplicated malaria disease in most endemic countries. Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell. Here, the cytogenotoxicity of dihydroartemisinin-piperaquine phosphate (DHAP), a coformulation for artemisinin-based combination therapy, was evaluated using model. Read More

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http://dx.doi.org/10.1155/2018/4671326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126092PMC

Estimation and Human Health Risk Assessment of Organochlorine Pesticides in Raw Milk Marketed in Zagazig City, Egypt.

J Toxicol 2018 12;2018:3821797. Epub 2018 Aug 12.

Food Control Department, Faculty of Veterinary Medicine, Zagazig University, 44519, Egypt.

Milk is nearly a perfect natural food and is widely used by all segments of our population especially for infants and the elderly. Organochlorine pesticides (OCPs) have been used worldwide, particularly in many African countries as in Egypt for the control of pests. OCPs are characterized by their bioaccumulation in the environment, especially in the food chain, where they find their way into the human body. Read More

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https://www.hindawi.com/journals/jt/2018/3821797/
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http://dx.doi.org/10.1155/2018/3821797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109547PMC
August 2018
20 Reads

Genotoxicity of Copper and Nickel Nanoparticles in Somatic Cells of .

J Toxicol 2018 19;2018:7278036. Epub 2018 Jul 19.

Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès (Barcelona), Spain.

Copper and nickel nanoparticles (Cu-NPs and Ni-NPs, respectively) are used in a variety of industrial applications, such as semiconductors, catalysts, sensors, and antimicrobial agents. Although studies on its potential genotoxicity already exist, few of them report data. In the present study we have used the wing-spot assay in to determine the genotoxic activity of Cu-NPs and Ni-NPs, and these data have been compared with those obtained with their microparticle forms (MPs). Read More

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http://dx.doi.org/10.1155/2018/7278036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077325PMC
July 2018
1 Read

An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin.

J Toxicol 2018 16;2018:6872753. Epub 2018 Jul 16.

Vimta Labs Limited, Pre-Clinical Division, Vimta Life Sciences Facility, Plot No. 5, MN Science and Technology Park, Genome Valley, Hyderabad 500 078, India.

A battery of toxicological studies was conducted in accordance with international guidelines to investigate the genotoxicity and repeated-dose oral toxicity in rats of synthetic curcumin (VEAMIN 99, >99% purity). There was no evidence of mutagenicity in a bacterial reverse mutation test, whereas an in vitro mammalian chromosomal aberration test was positive for induction of chromosomal aberrations which is in line with results reported for natural curcumin. There was no evidence of genotoxicity in an in vivo mammalian micronucleus test. Read More

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https://www.hindawi.com/journals/jt/2018/6872753/
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http://dx.doi.org/10.1155/2018/6872753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077508PMC
July 2018
25 Reads

Microbiological Quality and Risk Assessment for Aflatoxins in Groundnuts and Roasted Cashew Nuts Meant for Human Consumption.

J Toxicol 2018 3;2018:1308748. Epub 2018 Jun 3.

Department of Animal Health, School of Agriculture, Faculty of Agriculture, Science and Technology, North-West University, Mafikeng Campus, Private Bag X2046, Mmabatho 2735, South Africa.

Nuts are one of the commonly consumed snacks but poor handling and storage practices can make them prone to foodborne infections. The study aimed at assessing the microbiological quality and risk assessment for aflatoxins in groundnuts and cashew nuts consumed in selected locations in Nigeria. The moisture content, colony counts, incidence of pathogenic bacteria, aflatoxin contamination, and risk assessment for aflatoxins were evaluated using standard methods. Read More

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http://dx.doi.org/10.1155/2018/1308748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038661PMC
June 2018
92 Reads

An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp.

J Toxicol 2018 7;2018:8143582. Epub 2018 Jun 7.

Toxi-Coop Zrt., Magyar Jakobinusok Tere 4/B, Budapest 1122, Hungary.

A battery of toxicological studies was conducted on a supercritical CO extract of the aerial parts of the plant, containing approximately 25% cannabinoids. No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames), in an in vitro mammalian chromosomal aberration test, or in an in vivo mouse micronucleus study. A 14-day repeated oral dose-range finding study conducted in Wistar rats at 1000, 2000, and 4000 mg/kg bw/day resulted in effects where a NOAEL could not be concluded. Read More

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http://dx.doi.org/10.1155/2018/8143582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011091PMC
June 2018
32 Reads

Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements.

J Toxicol 2018 10;2018:9412167. Epub 2018 May 10.

R&D, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Industrial Area, 19th KM Stone, Hosur Road, Bangalore, Karnataka 560100, India.

Herbal products are being used and trusted globally for thousands of years for their health benefits and limited side effects. Globally, a general belief amongst the consumers is that herbal supplements are always safe because they are "natural." But later, research reveals that they may not be safe. Read More

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http://dx.doi.org/10.1155/2018/9412167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971330PMC
May 2018
2 Reads

Synergistic Effect of Quercetin and -Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats.

J Toxicol 2018 16;2018:2817036. Epub 2018 May 16.

Department of Biochemistry, College of Science, P.O. Box 22452, King Saud University, Riyadh 11495, Saudi Arabia.

Objectives: The present study was carried out to study the protective effects of quercetin and -lipoic acid alone and in combination against aluminum chloride induced neurotoxicity in rats.

Materials And Methods: The study consisted of eight groups, namely, Group 1: control rats, Group 2: rats receiving aluminium chloride 7 mg/kg body weight intraperitoneal route (i.p) for two weeks, Group 3: rats receiving quercetin 50 mg/kg body weight i. Read More

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https://www.hindawi.com/journals/jt/2018/2817036/
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http://dx.doi.org/10.1155/2018/2817036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976966PMC
May 2018
3 Reads

Inventory of Toxic Plants in Morocco: An Overview of the Botanical, Biogeography, and Phytochemistry Studies.

J Toxicol 2018 3;2018:4563735. Epub 2018 May 3.

Laboratoire de Chimie Analytique et de Bromatologie, Faculté de Médecine et de Pharmacie, Université Mohamed V, Rabat, Morocco.

Since they are natural, plants are wrongly considered nondangerous; therefore people used them in various contexts. Each plant is used alone or in mixture with others, where knowledge and the requirements of preparation and consumption are not mastered. Thus, intoxications due to the use of plants have become more and more frequent. Read More

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https://www.hindawi.com/journals/jt/2018/4563735/
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http://dx.doi.org/10.1155/2018/4563735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960541PMC
May 2018
9 Reads

Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application.

J Toxicol 2018 15;2018:5475784. Epub 2018 Apr 15.

IBR (Israeli Biotechnology Research) Ltd., 8122503 Yavne, Israel.

The colorless carotenoids phytoene and phytofluene are comparatively understudied compounds found in common foods (e.g., tomatoes) and in human plasma, internal tissues, and skin. Read More

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http://dx.doi.org/10.1155/2018/5475784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925131PMC

Aquatic Toxic Analysis by Monitoring Fish Behavior Using Computer Vision: A Recent Progress.

J Toxicol 2018 3;2018:2591924. Epub 2018 Apr 3.

The Key Laboratory of Water and Air Pollution Control of Guangdong Province, South China Institute of Environmental Sciences, MEP, Guangzhou 510065, China.

Video tracking based biological early warning system achieved a great progress with advanced computer vision and machine learning methods. Ability of video tracking of multiple biological organisms has been largely improved in recent years. Video based behavioral monitoring has become a common tool for acquiring quantified behavioral data for aquatic risk assessment. Read More

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http://dx.doi.org/10.1155/2018/2591924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903295PMC
April 2018
1 Read

Cinnamon in Anticancer Armamentarium: A Molecular Approach.

J Toxicol 2018 29;2018:8978731. Epub 2018 Mar 29.

UGC-DAE Consortium for Scientific Research, Kolkata Centre, Sector-III, Block-LB-8, Salt Lake, Kolkata, West Bengal 700106, India.

In recent years, natural bioactive components draw a major attention for their potent anticarcinogenic activity. Cinnamon, one of the traditional spices, most frequently used in almost every household of tropical countries has got enormous efficacy to combat cancer. Cinnamon as a whole and/or its active components exhibited significant antineoplastic activity in different types of cancer. Read More

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http://dx.doi.org/10.1155/2018/8978731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896244PMC

Reactive Oxygen Species Generation in Human Cells by a Novel Magnetic Resonance Imaging Contrast Agent.

J Toxicol 2018 26;2018:6362426. Epub 2018 Mar 26.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The novel positive-contrast magnetic resonance imaging (MRI) marker C4 consists of an aqueous solution of cobalt chloride (CoCl) complexed with the chelator N-acetylcysteine (NAC). We evaluated whether the presence of C4 or its components would produce reactive oxygen species (ROS, including hydroxyl, peroxyl, or other reactive oxygen species) in cultured cells. Human cancer or normal cells were incubated with 1% (w/v) CoCl·6HO or 2% NAC or a combination of both (1% CoCl·6HO : 2% NAC in an aqueous solution, abbreviated as Co : NAC) in the presence or absence of HO. Read More

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http://dx.doi.org/10.1155/2018/6362426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892220PMC
March 2018
6 Reads

Implementation of Fractal Dimension and Self-Organizing Map to Detect Toxic Effects of Toluene on Movement Tracks of .

J Toxicol 2018 26;2018:2637209. Epub 2018 Feb 26.

The Key Laboratory of Water and Air Pollution Control of Guangdong Province, South China Institute of Environmental Sciences, MEP, Guangzhou 510655, China.

Movement behaviors of an indicator species, , in response to contaminants have been implemented to monitor environmental disturbances. Complexity in movement tracks of was characterized by use of fractal dimension and self-organizing map. The individual movement tracks of were continuously recorded for 24 hours before and after treatments with toluene at the concentration of 10 mg/L, respectively. Read More

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http://dx.doi.org/10.1155/2018/2637209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846358PMC
February 2018
1 Read

A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™).

J Toxicol 2018 23;2018:5243617. Epub 2018 Jan 23.

Liveon Biolabs (P) Ltd., Tumkur, Karnataka 572106, India.

A series of toxicological investigations were conducted in order to evaluate the genotoxic potential and repeated-dose oral toxicity of CuroWhite, a proprietary extract of curcumin that has been hydrogenated and standardized to not less than 25% hydrogenated curcuminoid content. All tests were conducted in general accordance with internationally accepted standards. The test item was not mutagenic in the bacterial reverse mutation test or in vitro mammalian chromosomal aberration test, and no in vivo genotoxic activity was observed in rat bone marrow in the micronucleus test. Read More

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http://dx.doi.org/10.1155/2018/5243617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828043PMC
January 2018
2 Reads

and Toxicity Evaluation of Hydroethanolic Extract of (Crassulaceae) Leaves.

J Toxicol 2018 21;2018:6849765. Epub 2018 Jan 21.

Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

The species , known as , has anti-inflammatory, antimicrobial, and antihistamine activities. It also has the quercetin and kaempferol flavonoids, which exert their therapeutic activities. With extensive popular use besides the defined therapeutical properties, the study of possible side effects is indispensable. Read More

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http://dx.doi.org/10.1155/2018/6849765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822915PMC
January 2018
6 Reads

Acute Pesticide Poisoning in Children: Hospital Review in Selected Hospitals of Tanzania.

J Toxicol 2017 26;2017:4208405. Epub 2017 Dec 26.

School of Public Health & Family Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa.

Background: Acute pesticide poisoning (APP) is a serious problem worldwide. Because the burden of childhood APP is unknown in Tanzania, this study describes the distribution, circumstances, and patterns of APP involving children under 18 years in Tanzania.

Methodology: A 12-month prospective study was conducted in 10 Tanzanian healthcare facilities in 2006 using a data collection tool for surveillance. Read More

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http://dx.doi.org/10.1155/2017/4208405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758850PMC
December 2017
1 Read

Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia.

J Toxicol 2017 21;2017:6913106. Epub 2017 Dec 21.

Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, 44340 Guadalajara, JAL, Mexico.

Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, hydrolyzes several organophosphate pesticides and oxidized lipids. The PON1 Q192R polymorphism affects the catalytic efficiency and is considered a risk factor for pesticide intoxication and cardiovascular disease (CVD) but the association is not consistent between individuals or populations. We aimed to study the association of PON1 Q192R polymorphism with CVD risk in coffee harvesters of central Colombia. Read More

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http://dx.doi.org/10.1155/2017/6913106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753010PMC
December 2017
3 Reads

The Hypoactivity Associated with the Repeated Exposure to Atrazine Is Related to Decreases in the Specific Binding to D1-DA Receptors in the Striatum of Rats.

J Toxicol 2017 6;2017:2169212. Epub 2017 Dec 6.

Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, 76230 Querétaro, QRO, Mexico.

The herbicide atrazine (ATR) has a potential toxic effect on the neuronal circuits of the brain, specifically on two major dopaminergic pathways: the nigrostriatal and mesolimbic circuits. In this work, we repeatedly exposed adult male Sprague-Dawley rats to 6 injections of 100 mg ATR/kg of body weight (for two weeks) and one saline injection two days after ATR administration. Locomotor activity was assessed for 15 minutes and/or 2 hours after ATR or saline injection and 2 months after the final ATR administration. Read More

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http://dx.doi.org/10.1155/2017/2169212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736928PMC
December 2017
14 Reads