13,702 results match your criteria Journal of the neurological sciences[Journal]


Striatal dopamine transporter abnormalities associated with midbrain hemiatrophy.

J Neurol Sci 2019 Feb 16;399:94-96. Epub 2019 Feb 16.

Department of Neurology and Stroke Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jns.2019.02.026DOI Listing
February 2019

Predictive role of presenting symptoms and clinical findings in idiopathic intracranial hypertension.

J Neurol Sci 2019 Feb 6;399:89-93. Epub 2019 Feb 6.

Danish Headache Center, Department of Neurology, University of Copenhagen, Rigshospitalet-Glostrup, Denmark.

Background: The aim of the study was to evaluate the presenting symptoms and signs of idiopathic intracranial hypertension (IIH) in a large cohort of patients and to estimate their possible role in establishing the diagnosis of IIH.

Methods: This prospective cohort study in two tertiary centers, the Danish Headache Center in Rigshospitalet-Glostrup and the Neurology Clinic of the Clinical Center of Serbia, included 286 patients referred by attending specialists for possible IIH evaluation. Patients were divided into two groups: one with confirmed IIH diagnosis and one with rejected IIH diagnosis. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.006DOI Listing
February 2019

A startling acoustic stimulation (SAS)-TMS approach to assess the reticulospinal system in healthy and stroke subjects.

J Neurol Sci 2019 Feb 11;399:82-88. Epub 2019 Feb 11.

Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center, Houston, United States; TIRR Memorial Hermann Research Center, TIRR Memorial Hermann Hospital, United States.

Reticulospinal (RS) hyperexcitability is observed in stroke survivors with spastic hemiparesis. Habituated startle acoustic stimuli (SAS) can be used to stimulate the RS pathways non-reflexively. However, the role of RS pathways in motor function and its interactions with the corticospinal system after stroke still remain unclear. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.018DOI Listing
February 2019

Low-dose versus standard-dose intravenous alteplase for octogenerian acute ischemic stroke patients: A multicenter prospective cohort study.

J Neurol Sci 2019 Jan 29;399:76-81. Epub 2019 Jan 29.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background And Purpose: The optimal dose of alteplase for acute ischemic stroke among geriatric patients is unclear. We aimed to assess the efficacy and safety of a low-dose (0.6 mg/kg) and standard-dose (0. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.047DOI Listing
January 2019

Letter to editors regarding the article "Predictive score for oral corticosteroid-induced initial worsening of seropositive generalized myasthenia gravis".

J Neurol Sci 2019 Feb 11. Epub 2019 Feb 11.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.02.009DOI Listing
February 2019

Response to "regarding the article 'Predictive score for oral corticosteroid-induced initial worsening of seropositive generalized myasthenia gravis'".

J Neurol Sci 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1016/j.jns.2019.02.011DOI Listing
February 2019

Clinical and neuroimaging features of the m.10197G>A mtDNA mutation: New case reports and expansion of the phenotype variability.

J Neurol Sci 2019 Feb 6;399:69-75. Epub 2019 Feb 6.

IRCCS Fondazione Stella Maris, viale del Tirreno 331, 56128 Calambrone, Pisa, Italy.

Complex I (CI) is the largest component of the mitochondrial respiratory chain (MRC) and it is made up of 7 mitochondrial DNA (mtDNA)-encoded and at least 38 nuclear DNA-encoded subunits. Isolated CI deficiency is the most common single enzyme deficiency in the heterogeneous group of MRC disorders and it is a relatively common etiology of Leigh-like syndrome (LS). With a few exceptions, descriptions of the clinical spectrum of specific mutations in CI are scarce. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.010DOI Listing
February 2019

Traumatic brain injuries in New Zealand: National Insurance (Accident Compensation Corporation) claims from 2012 to 2016.

J Neurol Sci 2019 Feb 12;399:61-68. Epub 2019 Feb 12.

Australian College of Physical Education, Department of Sport Performance, Sydney Olympic Park NSW, Australia.

Aim: To provide epidemiological data and related costs to the national health insurance scheme for traumatic brain injury (TBI) in New Zealand.

Method: A retrospective analytical review utilising detailed descriptive minor and moderate-to-severe epidemiological TBI data obtained from the Accident Compensation Corporation (ACC) for 2012-2016. Injuries were analysed by three levels of increasing severity: moderate, moderate-to-serious (MSC) and severe claims categories. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.049DOI Listing
February 2019

Deep brain stimulation of the subthalamic nucleus in Parkinson's disease patients over 75 years of age.

J Neurol Sci 2019 Feb 11;399:57-60. Epub 2019 Feb 11.

Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.

Introduction: Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease (PD). However, its effect in older patients is not extensively studied, as they are often excluded from DBS surgery due to concerns of complications or reduced benefit. We assessed clinical outcomes after subthalamic nucleus (STN) DBS in older patients (age > 75 years) with PD. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.019DOI Listing
February 2019
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NT-pro-BNP correlates with disease severity and predicts outcome in cerebral haemorrhage patients: Cohort study.

J Neurol Sci 2019 Feb 8;399:51-56. Epub 2019 Feb 8.

Internal Medicine Department, São João Hospital Centre, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Stroke Unit, São João Hospital Centre, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.

Background: Intracerebral haemorrhage (ICH) is a devastating condition, with more than half of patients dying or becoming dependent after such an event. Natriuretic peptides, frequently used in the management of heart failure, have been shown to correlate with disease severity and prognosis in brain disorders. The aim of this study was to test the hypothesis that NT-pro-BNP correlates with disease severity and is an independent prognostic marker for non-traumatic ICH patients. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.014DOI Listing
February 2019

Effectiveness of botulinum neurotoxin type A injections in naïve and previously-treated patients suffering from Torti- or Laterocollis or -caput: Results from a German-Austrian open-label prospective post-marketing surveillance study.

J Neurol Sci 2019 Feb 10;399:44-50. Epub 2019 Feb 10.

Klinik und Poliklinik für Neurologie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

AbobotulinumtoxinA (aboBoNT-A; Dysport®) is an effective treatment for cervical dystonia (CD) with a well-established safety profile. In this prospective, multicentre, non-interventional study (NCT01840462) the primary objective was effectiveness (Tsui score) of aboBoNT-A in botulinum neurotoxin type A (BoNT-A) treatment-naïve and previously-treated (>2 yrs) patients after two injection cycles (at visit 3). Secondary objectives included the effectiveness of aboBoNT-A overall visits and quality of life (CDQ-24) in different CD subtypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193007
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http://dx.doi.org/10.1016/j.jns.2019.02.017DOI Listing
February 2019
4 Reads

Evaluation of brain volume alterations in HCV-infected patients after interferon-free therapy: A pilot study.

J Neurol Sci 2019 Feb 7;399:36-43. Epub 2019 Feb 7.

Department of General Radiology, Interventional Radiology and Neuroradiology, Radiology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

The study was performed to evaluate cerebral volume changes in HCV-infected subjects before and after interferon-free therapy with direct-acting antiviral agents (DAA). We aimed also to estimate the impact of successful DAA therapy on the neuropsychological state of patients. Eleven HCV genotype 1 (GT1) patients treated with ombitasvir/paritaprevir (boosted with ritonavir) and dasabuvir, with or without ribavirin underwent brain magnetic resonance (MR) before and 24 weeks after completion of therapy. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.002DOI Listing
February 2019
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Acute sensorineural hearing loss in patients with vestibular schwannoma early after cyberknife radiosurgery.

J Neurol Sci 2019 Feb 6;399:30-35. Epub 2019 Feb 6.

Departments of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objective: This study reviewed our experience in treating patients with vestibular schwannoma (VS) who had acute sensorineural hearing loss (ASHL) early after radiosurgery.

Patients And Methods: Seventy VS patients underwent cyberknife radiosurgery. Of them, 6 patients had ASHL early (<6 m) after radiosurgery (Group A), accounting for 8. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.008DOI Listing
February 2019

Neural correlates of distinct cognitive phenotypes in early Parkinson's disease.

J Neurol Sci 2019 Feb 7;399:22-29. Epub 2019 Feb 7.

University of California San Diego, Department of Neurosciences, La Jolla, CA, USA.

Objective: Cognitive decline is common in Parkinson's disease (PD), but changes can occur in a variety of cognitive domains. The lack of a single cognitive phenotype complicates diagnosis and tracking. In an earlier study we used a data-driven approach to identify distinct cognitive phenotypes of early PD. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.013DOI Listing
February 2019
2 Reads

RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage.

J Neurol Sci 2019 Feb 5;399:6-14. Epub 2019 Feb 5.

Neurology, Henry Ford Hospital, Detroit MI-48202, USA. Electronic address:

Subarachnoid hemorrhage (SAH) results in neurological damage, acute cardiac damage and has a high mortality rate. Immunoresponse in the acute phase after SAH plays a key role in mediating vasospasm, edema, inflammation and neuronal damage. The S1P/S1PR pathway impacts multiple cellular functions, exerts anti-inflammatory and anti-apoptotic effects, promotes remyelination, and improves outcome in several central nervous system (CNS) diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193006
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http://dx.doi.org/10.1016/j.jns.2019.02.005DOI Listing
February 2019
3 Reads
2.474 Impact Factor

Cognitive dysfunction in mice with passively induced MuSK antibody seropositive myasthenia gravis.

J Neurol Sci 2019 Feb 4;399:15-21. Epub 2019 Feb 4.

Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden.

Recent reports on cognitive dysfunction, in addition to skeletal muscle fatigue, in muscle-specific tyrosine kinase antibody seropositive (MuSK+) myasthenia gravis (MG) patients led us to study cognition in mice with MuSK+ passive transfer MG (PTMG). Twelve 7-week-old female wild-type C57BL/6J mice were passively immunized with IgG from MuSK+ MG patients and 12 control mice received intraperitoneal saline injections. Mice were evaluated with clinical, neurophysiological and behavioral tests (Barnes maze (BM) and novel object recognition (NOR)), and the muscles were immunostained to evaluate the neuromuscular junction in the end of the study. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.001DOI Listing
February 2019

Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.

J Neurol Sci 2019 Feb 1;399:3-5. Epub 2019 Feb 1.

Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.01.051DOI Listing
February 2019

The "eye of the tiger" in a patient with multiple sclerosis.

Authors:
Shin C Beh

J Neurol Sci 2019 Feb 5;399:1-2. Epub 2019 Feb 5.

Department of Neurology, University of Texas Southwestern Medical Center, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.02.003DOI Listing
February 2019
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The role of repetitive transcranial magnetic stimulation (rTMS) in the treatment of cognitive impairment in patients with Alzheimer's disease: A systematic review and meta-analysis.

J Neurol Sci 2019 Jan 24;398:184-191. Epub 2019 Jan 24.

Department of Gerontology, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address:

Background: Although repetitive transcranial magnetic stimulation (rTMS) has been considered a potentially effective treatment for cognitive impairment in patients with Alzheimer's disease (AD), previous studies have produced inconsistent results. The objective of this meta-analysis was to evaluate the effects of rTMS on cognitive function in patients with AD.

Methods: PubMed, EMBASE, Web of Science, MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for relevant terms. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.038DOI Listing
January 2019
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Viral (aseptic) meningitis: A review.

J Neurol Sci 2019 Jan 31;398:176-183. Epub 2019 Jan 31.

Division of Hospital Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pinnacle, United States.

Viral meningitis is an inflammation of the meninges associated with acute onset of meningeal symptoms and fever, pleocytosis of the cerebrospinal fluid, and no growth on routine bacterial culture. It is sometimes associated with viral encephalitis and meningoencephalitis. Viruses reach the central nervous system (CNS) hematogenously or in a retrograde manner from nerve endings. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.050DOI Listing
January 2019
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Progress of intracranial pressure and cerebral perfusion pressure in patients during the development of brain death.

J Neurol Sci 2019 Jan 29;398:171-175. Epub 2019 Jan 29.

Department of Anesthesiology, University of Marburg, Marburg, Germany; Pain Center, Kassel, Germany.

Background: Clinical investigations of brain death are supposed to prove absence of cerebral perfusion. However, only limited data are available documenting intracranial pressure (ICP) and cerebral perfusion pressure (CPP) during the development of brain death. Our study presents additional data to understand the course of ICP and CPP in patients developing brain death. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.048DOI Listing
January 2019

Real-world durability of relapse rate reduction in patients with multiple sclerosis receiving fingolimod for up to 3 years: a retrospective US claims database analysis.

J Neurol Sci 2019 Jan 22;398:163-170. Epub 2019 Jan 22.

Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover, NJ, USA.

Objective: To assess real-world durability of reduction in relapse rates among patients with multiple sclerosis (MS) receiving fingolimod therapy over a longer-term period of follow-up.

Methods: Patients with MS who initiated fingolimod were identified from a US claims database (January 1, 2009 to September 30, 2016) and followed for 3 years post-initiation. Annualized relapse rates (ARRs) were calculated during the 1-year pre-initiation period, and during each year over the 3-year follow-up period. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.036DOI Listing
January 2019
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Cerebrovascular reactivity in subjects with migraine: Age paradox?

J Neurol Sci 2019 Jan 25. Epub 2019 Jan 25.

Neurology Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2019.01.040DOI Listing
January 2019

A score using left ventricular diastolic dysfunction to predict 90-day mortality in acute ischemic stroke: The DONE score.

J Neurol Sci 2019 Jan 17;398:157-162. Epub 2019 Jan 17.

Department of Neurology and Strokology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Purpose: The aim of this study was to identify whether diastolic dysfunction predicts death at 90 days after acute ischemic stroke.

Methods: We retrospectively analyzed patients with ischemic stroke. All patients underwent transthoracic echocardiography to evaluate systolic function and diastolic function by means of assessing ejection fraction and septal E/e'. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.021DOI Listing
January 2019
2.474 Impact Factor

A retrospective evaluation of thalamic targeting for tremor deep brain stimulation using high-resolution anatomical imaging with supplementary fiber tractography.

J Neurol Sci 2019 Jan 16;398:148-156. Epub 2019 Jan 16.

Department of Neurosurgery, Fukuoka University, Faculty of Medicine, Fukuoka, Japan.

Objectives: Deep brain stimulation (DBS) of the ventral intermediate (Vim) thalamic nucleus is used to treat tremors. Here, we identified the Vim nucleus on fast gray matter acquisition T1 inversion recovery (FGATIR) images and delineated the dentate-rubrothalamic tract (DRT) to determine the DBS target. We evaluated whether this method could consistently identify the Vim nucleus by anatomical imaging and fiber tractography. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.025DOI Listing
January 2019

Clinical, neuropsychological and imaging characteristics of Alzheimer's disease patients presenting as corticobasal syndrome.

J Neurol Sci 2019 Jan 29;398:142-147. Epub 2019 Jan 29.

1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece, 72-74 Vas. Sophias Ave., 11528 Athens, Greece.

Background: Corticobasal syndrome (CBS) can harbor diverse pathologies, such as corticobasal degeneration (CBD) and Alzheimer's disease (AD). CSF biochemical analysis in CBS patients can confidently distinguish between an AD (CBS-AD) and a non-AD (CBS-nAD) pathology.

Objective: We utilized classical CSF biomarkers to make a distinction between the two groups and examine their clinical, neuropsychological, neuropsychiatric and imaging differences. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.046DOI Listing
January 2019
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Hepatitis B and C virus infection as a risk factor for Parkinson's disease in Israel-A nationwide cohort study.

J Neurol Sci 2019 Jan 11;398:138-141. Epub 2019 Jan 11.

Department of Neurology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: To study the association between hepatitis C and B viruses and Parkinson's disease (PD) in Israel.

Methods: A retrospective cohort study was performed by analyzing the computerized database of Clalit Healthcare Service in Israel. Cohorts of people with hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection and nonalcoholic steatohepatitis (NASH) were constructed and compared to a reference cohort for prevalence of PD. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.012DOI Listing
January 2019
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Radiological features and outcomes of essential thrombocythemia-related stroke.

J Neurol Sci 2019 Jan 22;398:135-137. Epub 2019 Jan 22.

Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Background: Essential thrombocythemia (ET) is known to be associated with an increased vascular event, but the stroke patterns and prognosis have not been studied.

Methods: Between January 2013 and December 2017, acute ischemic stroke patients with ET who were admitted to two tertiary hospital stroke centers in Seoul, Korea were included. We retrospectively reviewed their clinical, laboratory and imaging data. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.035DOI Listing
January 2019
1 Read

Paradoxical association between age and cerebrovascular reactivity in migraine: A cross-sectional study.

J Neurol Sci 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Previous studies reported an increased risk of ischemic stroke in younger migraineurs. We aimed to investigate the association between age and cerebrovascular reactivity (CVR) to vasodilatory stimuli in cerebral arteries in patients with migraine and normal controls.

Methods: In this cross-sectional study, we recruited 248 patients with migraine and 105 normal controls at Samsung Medical Center between October 2015 and July 2018. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.039DOI Listing
January 2019
1 Read

Seizure-triggered Takotsubo syndrome - A need for cooperation between neurologists and cardiologists.

J Neurol Sci 2019 Jan 14. Epub 2019 Jan 14.

Krankenanstalt Rudolfstiftung, Wien, Austria.

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http://dx.doi.org/10.1016/j.jns.2019.01.016DOI Listing
January 2019

Stroke revealing Neuro-Behçet's disease with parenchymal and extensive vascular involvement.

J Neurol Sci 2019 Jan 26;398:131-134. Epub 2019 Jan 26.

Neurology's Department, Mongi Ben Hmida National Institute of Neurology, Tunis, Tunisia.

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http://dx.doi.org/10.1016/j.jns.2019.01.044DOI Listing
January 2019

Isolated choroid plexus involvement in a case of granulomatosis with polyangiitis negative for antineutrophil cytoplasmic antibodies (ANCA).

J Neurol Sci 2019 Jan 26;398:128-130. Epub 2019 Jan 26.

Division of Neurology, Department of Neurosciences, Santa Chiara Hospital, Trento, Italy.

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http://dx.doi.org/10.1016/j.jns.2019.01.045DOI Listing
January 2019
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Neurologic manifestations associated with cryoglobulinemia: A single center experience.

J Neurol Sci 2019 Jan 25;398:121-127. Epub 2019 Jan 25.

Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States. Electronic address:

Introduction: Limited information is available describing the spectrum of neurological complications of cryoglobulinemia.

Methods: Single center retrospective review of patients with neurologic symptoms and elevated serum cryoglobulins, with their potential association being classified as definite, possible, or unlikely using defined criteria.

Results: Among 492 patients, 131 (87 classified as definite and 44 as possible) had neurologic symptoms associated with cryoglobulinemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193005
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http://dx.doi.org/10.1016/j.jns.2019.01.041DOI Listing
January 2019
5 Reads

Initiatives to reduce neurophobia in medical students: a novel neuroscience conference model.

J Neurol Sci 2019 Jan 25;398:119-120. Epub 2019 Jan 25.

Faculty of Life Sciences and Medicine, King's College London, London, UK.

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http://dx.doi.org/10.1016/j.jns.2019.01.042DOI Listing
January 2019

A rapidly progressive motor neuron disease associated to a natural killer cells leukaemia.

J Neurol Sci 2019 Jan 17;398:117-118. Epub 2019 Jan 17.

IRCCS Centro Neurolesi Bonino Pulejo, Palermo, Italy.

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http://dx.doi.org/10.1016/j.jns.2019.01.029DOI Listing
January 2019

Amyloid PET pattern with dementia and amyloid angiopathy in Taiwan familial AD with D678H APP mutation.

J Neurol Sci 2019 Jan 3;398:107-116. Epub 2019 Jan 3.

Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Introduction: The novel D678H amyloid precursor protein (APP) gene mutation has been called the "Taiwan mutation". The study aims to identify amyloid deposition patterns and clinical features associated with this mutation.

Methods: we analyzed the clinical manifestations, brain neuroimages and F-AV-45 positron emission tomography (PET) findings in symptomatic patients and asymptomatic subjects with the autosomal-dominant Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.jns.2018.12.039DOI Listing
January 2019
1 Read

Stroke risk factors in couples. A population-based study in community-dwelling adults living in a remote rural setting (the Atahualpa Project).

J Neurol Sci 2019 Jan 23;398:98-100. Epub 2019 Jan 23.

Department of Epidemiology, Gilead Sciences, Inc., Foster City, CA, USA.

Purpose: By the use of a population-based design, this study aimed to evaluate the presence of similar stroke risk factors in couples living in a remote rural setting (Atahualpa).

Methods: Atahualpa residents aged ≥40 years were identified by means of door-to-door surveys, and those who signed a comprehensive consent form were enrolled in the Atahualpa Project. Baselines interviews and procedures, aimed to assess stroke risk factors, were collected at the time of admission in all participants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193003
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http://dx.doi.org/10.1016/j.jns.2019.01.037DOI Listing
January 2019
2 Reads

The King-Devick test in an outpatient concussion clinic: Assessing the diagnostic and prognostic value of a vision test in conjunction with exercise testing among acutely concussed adolescents.

J Neurol Sci 2018 Dec 22;398:91-97. Epub 2018 Dec 22.

Department of Psychiatry, University at Buffalo, SUNY, Buffalo, NY 14214, United States.

Objective: This study investigated the diagnostic and prognostic value of the King-Devick (K-D) test in conjunction with treadmill testing in adolescents after sport-related concussion (SRC) in an outpatient concussion management clinic without baseline measures.

Design: Prospective cohort.

Methods: The K-D test was administered pre- and post-exercise on a graded treadmill test to acutely concussed (AC, <10 days from injury, n = 46, 15. Read More

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http://dx.doi.org/10.1016/j.jns.2018.12.020DOI Listing
December 2018

Impulse control disorders in Parkinson's disease: A systematic review on risk factors and pathophysiology.

J Neurol Sci 2019 Jan 22;398:101-106. Epub 2019 Jan 22.

IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy. Electronic address:

Aim: Purpose of this review is to evaluate the potential risk factors that may predispose to the development of Impulse control disorders (ICDs) in Parkinson's Disease (PD) patients, including the effects of dopaminergic therapy.

Methods: This descriptive review was conducted to identificate risk factors that could cause impulsive control disorders in PD. Studies were found on PubMed (2010-2018), Web Of Science (January 2010-July 2018) and Cochrane (2010-2018) databases. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.034DOI Listing
January 2019

Rodent models with expression of PMP22: Relevance to dysmyelinating CMT and HNPP.

J Neurol Sci 2019 Jan 21;398:79-90. Epub 2019 Jan 21.

Department of Neurology, CHU Limoges, Dupuytren University Hospital, 2 avenue Martin Luther King, 87042 Limoges, France; National Reference Center for 'Rare Peripheral Neuropathies', CHU Limoges, Dupuytren University Hospital, 2 avenue Martin Luther King, 87042 Limoges, France. Electronic address:

Background: Charcot-Marie-Tooth diseases (CMT) are due to abnormalities of many genes, the most frequent being linked to PMP22 (Peripheral Myelin Protein 22). In the past, only spontaneous genetic anomalies occurring in mouse mutants such as Trembler (Tr) mice were available; more recently, several rodent models have been generated for exploration of the pathophysiological mechanisms underlying these neuropathies.

Methods: Based on the personal experience of our team, we describe here the pathological hallmarks of most of these animal models and compare them to the pathological features observed in some CMT patient nerves (CMT types 1A and E; hereditary neuropathy with liability to pressure palsies, HNPP). Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.030DOI Listing
January 2019
1 Read

A novel mutation in the N-terminal acting-binding domain of Filamin C protein causing a distal myofibrillar myopathy.

J Neurol Sci 2019 Jan 17;398:75-78. Epub 2019 Jan 17.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, Largo Daneo 3, 16132 Genova, Italy; Ospedale Policlinico San Martino IRCCS-Neurological Unit, Largo R. Benzi 10, 16132 Genoa, Italy. Electronic address:

Variants in Filamin C (FLNC) gene may cause either cardiomyopathies or different myopathies. We describe a family affected by a distal myopathy with autosomal dominant inheritance. The onset of the disease was in the third decade with gait impairment due to distal leg weakness. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.019DOI Listing
January 2019
2 Reads

Cephalosporin neurotoxicity: An overlooked cause of toxic-metabolic encephalopathy.

J Neurol Sci 2019 Jan 16. Epub 2019 Jan 16.

Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.jns.2018.12.007DOI Listing
January 2019

Maintenance dose of warfarin beyond time in therapeutic range for preventing vascular events.

J Neurol Sci 2019 Jan 18;398:69-74. Epub 2019 Jan 18.

Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea; The Korean Cerebrovascular Research Institute, Republic of Korea. Electronic address:

Background: The quality of anticoagulation is closely associated with efficacy and safety in warfarin users. Although genetic polymorphisms have been related to warfarin dosages and vascular events(VE), genetic evaluations have not been recommended for all warfarin users. The aim is to evaluate the significance of the maintenance dose of warfarin (MDW) on VE, considering the time in therapeutic range (TTR). Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.031DOI Listing
January 2019
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Serious central nervous system side effects of cephalosporins: A national analysis of serious reports registered in the French Pharmacovigilance Database.

J Neurol Sci 2019 Jan 16. Epub 2019 Jan 16.

Centre Régional de Pharmacovigilance, Service de Pharmacologie Clinique et Pharmacovigilance, APHM, INSERM, Inst Neurosci Syst, Aix Marseille Univ, Marseille, France. Electronic address:

Introduction: Among antibiotics, Central Nervous System (CNS) adverse drug reactions (ADRs) are often under-suspected and overlooked. Cephalosporins are an important cause of drug-induced CNS ADRs but the characteristics of such ADR have not been fully explored. We aimed to characterize the profile of cephalosporins serious CNS ADRs. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.018DOI Listing
January 2019
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Intracerebral hemorrhage outcome: A comprehensive update.

J Neurol Sci 2019 Jan 14;398:54-66. Epub 2019 Jan 14.

Neurology Department, Hospital de Braga, Portugal.

Non-traumatic intracerebral hemorrhage (ICH) is associated with a significant global burden of disease, and despite being proportionally less frequent than ischemic stroke, in 2010 it was associated with greater worldwide disability-adjusted life years lost. The focus of outcome assessment after ICH has been mortality in most studies, because of the high early case fatality which reaches 40% in some population-based studies. The most robust and consistent predictors of early mortality include age, severity of neurological impairment, hemorrhage volume and antithrombotic therapy at the time of the event. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.013DOI Listing
January 2019
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Interleukin-6 and amyotrophic lateral sclerosis.

J Neurol Sci 2019 Jan 16;398:50-53. Epub 2019 Jan 16.

Institute of Physiology and Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal; Department of Neurosciences and Mental Health, Hospital de Santa Maria-CHLN, Lisbon, Portugal. Electronic address:

Background: IL-6 is an inflammatory cytokine that is a possible factor in progression of the disease. We have investigated venous blood levels of IL-6 in controls and ALS patients in relation to clinical staging and respiratory function.

Methods: We studied 82 patients with ALS and 43 age and gender-matched healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.026DOI Listing
January 2019
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Gait analysis in a component timed-up-and-go test using a smartphone application.

J Neurol Sci 2019 Jan 16;398:45-49. Epub 2019 Jan 16.

Digital Standard Co., Ltd., 2-6-24 Sonezakishinchi, Kita-ku, Osaka, Japan. Electronic address:

Background: The timed-up-and-go test (TUG) is a popular test for mobility, but it only measures the total time to complete tasks. Recent advances in smartphone technology enables measuring respective times of 6 components in the test (Stand, Go, Turn1, Come, Turns and Sit). We examined availability of these data for assessing different gait patterns. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.023DOI Listing
January 2019

Serum magnesium level and hematoma expansion in patients with intracerebral hemorrhage.

J Neurol Sci 2019 Jan 16;398:39-44. Epub 2019 Jan 16.

Department of Neurology, University of Minnesota, Minneapolis, MN, United States; Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States. Electronic address:

Spontaneous intracerebral hemorrhage (ICH) is a devastating subtype of stroke that results in significant rates of mortality and morbidities. The initial hematoma volume, hematoma expansion (HE), blood pressure (BP), and coagulopathy are considered strong predictors of clinical outcomes and mortality. Low serum magnesium (Mg) levels have been shown to be associated with larger initial hematoma and greater HE. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.027DOI Listing
January 2019
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Cortical thinning across Parkinson's disease stages and clinical correlates.

J Neurol Sci 2019 Jan 17;398:31-38. Epub 2019 Jan 17.

Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address:

Background: Imaging studies have revealed cortical thinning and subcortical atrophy occurring in Parkinson's disease (PD); however, the topographical distribution and clinical associations related to advancing stages of PD remains unclear.

Objective: We aimed to investigate the topographical distribution of cortical and subcortical morphometric changes, and their clinical associations, related to increasing disease severity.

Methods: In this cross-sectional imaging study, T1-weighted structural magnetic resonance imaging data for 80 non-demented PD patients and 30 age-matched healthy controls were analysed using FreeSurfer software suite to derive morphometric changes using whole-brain vertex-wise analysis, and surface-based (cortical) and volume-based (subcortical) parcellation maps. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.020DOI Listing
January 2019
7 Reads