1,055 results match your criteria Journal of the Renin-Angiotensin-Aldosterone System[Journal]


The angiotensin II type 1 receptor blocker azilsartan can overwhelm the sympathetic nerve activation stimulated by coadministration of calcium channel blockers.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319839525

1 Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan.

Objective:: In our recent study, non-Gaussianity of heart rate variability (λ), an indicator of sympathetic nerve activity, did not change during two-day treatment with the angiotensin II type 1 receptor blocker (ARB) azilsartan. Coadministration of calcium channel blockers (CCBs) might affect the study results.

Methods:: In this subanalysis, 20 patients with chronic kidney disease (14 men; age 61±15 years) were divided into three groups: patients with coadministration of L-type CCB, patients without coadministration of CCB, and patients with coadministration of sympathoinhibitory (L/T- or L/T/N-type) CCB. Read More

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http://dx.doi.org/10.1177/1470320319839525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437324PMC

Genetic knockdown of brain-derived neurotrophic factor in the nervous system attenuates angiotensin II-induced hypertension in mice.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319834406

2 Department of Psychological and Brain Sciences, University of Iowa, USA.

Introduction:: Brain-derived neurotropic factor (BDNF) is expressed throughout the central nervous system and peripheral organs involved in the regulation of blood pressure, but the systemic effects of BDNF in the control of blood pressure are not well elucidated.

Materials And Methods:: We utilized loxP flanked BDNF male mice to cross with nestin-Cre female mice to generate nerve system BDNF knockdown mice, nestin-BDNF (+/-), or injected Cre adenovirus into the subfornical organ to create subfornical organ BDNF knockdown mice. Histochemistry was used to verify injection location. Read More

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http://dx.doi.org/10.1177/1470320319834406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429654PMC
March 2019
1 Read

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch-Schönlein purpura: a meta-analysis.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319836302

Department of Pediatrics, Hangzhou Hospital of Traditional Chinese Medicine, China.

Objective:: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch-Schönlein purpura.

Methods:: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Read More

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http://dx.doi.org/10.1177/1470320319836302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413430PMC

Syndrome of inappropriate secretion of antidiuretic hormone associated with angiotensin-converting enzyme inhibitor therapy in the perioperative period.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319834409

1 Department of Internal Medicine, Ashikaga Red Cross Hospital, Japan.

Introduction:: Angiotensin-converting enzyme (ACE) inhibitors are one of the most commonly used medications for hypertension. Rarely, ACE inhibitors have the potential to cause a syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

Case Presentation:: A 70-year-old woman with > 10 years ACE inhibitor therapy with normonatremia suddenly developed severe SIADH when she took a liquid diet in the uneventful perioperative period, with hemodynamic stability and no surgical complications. Read More

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http://dx.doi.org/10.1177/1470320319834409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407162PMC
March 2019
1 Read

The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319827449

1 Bioscience CKD, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Sweden.

Introduction:: AZD9977 is a novel mineralocorticoid receptor (MR) modulator, which in preclinical studies demonstrated organ protection without affecting aldosterone-regulated urinary electrolyte excretion. However, when tested in humans, using fludrocortisone as an MR agonist, AZD9977 exhibited similar effects on urinary Na/K ratio as eplerenone. The aim of this study is to understand whether the contradictory results seen in rats and humans are due to the mineralocorticoid used. Read More

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http://dx.doi.org/10.1177/1470320319827449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396052PMC
March 2019
1 Read

Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320318823927

1 Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, China.

Objective:: Although the angiotensinogen ( AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. The present meta-analysis was conducted to determine the correlation of AGT T174M polymorphism with DN.

Methods:: We retrospectively extracted relevant studies from Embase as well as PubMed databases. Read More

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http://dx.doi.org/10.1177/1470320318823927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350140PMC
February 2019
1 Read

Association of mononucleotide polymorphisms of angiotensinogen gene at promoter region with antihypertensive response to angiotensin receptor blockers in hypertensive Chinese.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319827205

Department of Cardiology, Beijing Tiantan Hospital, Capital University of Medical Science, People's Republic of China.

Introduction:: This study aimed to investigate whether mononucleotide polymorphisms of the angiotensinogen gene at promoter were associated with the blood-pressure-lowering response to telmisartan treatment.

Materials And Methods:: After a two-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy with 80 mg/day of telmisartan and then were followed up for eight weeks. The -6A/G and -20A/C polymorphisms of the angiotensinogen gene at promoter were determined through polymerase chain reaction and restriction fragment length polymorphsim analysis. Read More

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http://dx.doi.org/10.1177/1470320319827205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362516PMC
February 2019

Association of angiotensin ІІ type 1 receptor gene A1166C polymorphism with cancer risk: An updated meta-analysis.

Authors:
Xue Hu Jing Chen

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319827207

Department of Occupation Medicine, Hangzhou Hospital for the Prevention and Treatment of Occupational Diseases, China.

Objective:: The association between angiotensin II type 1 receptor ( AGTR1) gene A1166C polymorphism and cancer risk has been investigated in many studies. However, the results have been inconclusive. A meta-analysis was performed to obtain a more precise estimation of the relationship. Read More

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http://dx.doi.org/10.1177/1470320319827207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362515PMC
February 2019
1 Read

The association between apelin polymorphisms and hypertension in China: A meta-analysis.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319827204

2 China-Japan Union Hospital, Jilin University, Changchun, Jilin, China.

Introduction:: Apelin plays an important part in regulating blood pressure, metabolism, and the development of cancer. Recent studies have investigated the association of apelin polymorphisms and hypertension risk, but no meta-analysis has been conducted.

Materials And Methods:: Five studies were included in this meta-analysis in total. Read More

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http://dx.doi.org/10.1177/1470320319827204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376513PMC
February 2019

The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension.

J Renin Angiotensin Aldosterone Syst 2018 Oct-Dec;19(4):1470320318810022

1 1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Kraków, Poland.

Introduction:: The aim of the study was to evaluate clinical and biochemical differences between patients with low-renin and high-renin primary arterial hypertension (AH), mainly in reference to serum lipids, and to identify factors determining lipid concentrations.

Materials And Methods:: In untreated patients with AH stage 1 we measured plasma renin activity (PRA) and subdivided the group into low-renin (PRA < 0.65 ng/mL/h) and high-renin (PRA ⩾ 0. Read More

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http://journals.sagepub.com/doi/10.1177/1470320318810022
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http://dx.doi.org/10.1177/1470320318810022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240969PMC
January 2019
15 Reads
2.271 Impact Factor

Salt and cardiovascular disease in PURE: A large sample size cannot make up for erroneous estimations.

J Renin Angiotensin Aldosterone Syst 2018 Oct-Dec;19(4):1470320318810015

Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK.

The latest Prospective Urban Rural Epidemiology (PURE) study claims that salt reduction should be confined to settings where its intake exceeds 12.7 g/day and that eating less than 11.1 g/day of salt could increase cardiovascular risk. Read More

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http://journals.sagepub.com/doi/10.1177/1470320318810015
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http://dx.doi.org/10.1177/1470320318810015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240978PMC
January 2019
12 Reads

Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists.

J Renin Angiotensin Aldosterone Syst 2018 Oct-Dec;19(4):1470320318810940

1 Obstetrics and Gynaecology Department, Besançon University Medical Centre, Franche-Comté University, France.

We report a case of prenatal exposure to angiotensin II receptor antagonists (ARA II) from the beginning of pregnancy in a patient with a hypokinetic dilated cardiomyopathy. This case report emphasizes the fetal renal impact of prolonged intrauterine exposure to renin-angiotensin system (RAS) blockers, and highlights that this exposure can cause severe prenatal hypocalvaria. This delayed ossification can be reversible after birth, but the presence of anhydramnios indicates an early and irreversible block of RAS blockers in the fetus that is responsible for fetal kidney development abnormalities. Read More

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http://dx.doi.org/10.1177/1470320318810940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243420PMC
January 2019
17 Reads

His-Leu, an angiotensin I-derived peptide, does not affect haemodynamics in rats.

J Renin Angiotensin Aldosterone Syst 2018 Oct-Dec;19(4):1470320318808879

1 Department of Experimental Physiology and Pathophysiology, Laboratory of the Centre for Preclinical Research, Medical University of Warsaw, Poland.

Introduction:: The dipeptide histidine-leucine (His-Leu) is formed in the process of converting angiotensin I into angiotensin II. Several studies show that short peptides containing His-Leu may produce significant haemodynamic effects; however, to the best of our knowledge, data on haemodynamic effects of His-Leu are not available in medical databases.

Materials And Methods:: We evaluated acute haemodynamic effects of intravenous administration of either 0. Read More

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http://dx.doi.org/10.1177/1470320318808879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207977PMC
January 2019
19 Reads

Effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on cardiovascular events in patients with diabetes and overt nephropathy: a meta-analysis of randomised controlled trials.

J Renin Angiotensin Aldosterone Syst 2018 Oct-Dec;19(4):1470320318803495

3 Changchun University of Chinese Medicine, China.

Objective: The efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in reducing cardiovascular outcomes in patients with diabetes and overt nephropathy is still a controversial issue.

Methods: We systematically searched MEDLINE, Embase and Cochrane Library for randomised controlled trials.

Results: Thirteen trials containing 4638 patients with diabetes and overt nephropathy were included. Read More

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http://journals.sagepub.com/doi/10.1177/1470320318803495
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http://dx.doi.org/10.1177/1470320318803495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178369PMC
January 2019
5 Reads

Long-term clinical spectrum and circulating RAS evaluation of anephric patients undergoing hemodialysis: A report of four cases and literature review.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318799904

Department of Nephrology, China-Japan Friendship Hospital, Beijing, PR China.

Introduction: Bilateral nephrectomy leads to a short-term reduction in blood pressure. This is mainly due to a sharp change in the circulating renin-angiotensin system (RAS), but data on the long-term outcomes of their clinical status and further changes in circulating RAS are rare.

Materials And Methods: We enrolled four Chinese patients who had both of their kidneys removed two (1), six (1) and eight (2) years prior to this study, respectively. Read More

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http://dx.doi.org/10.1177/1470320318799904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166312PMC
January 2019
11 Reads

Hyperglycemia activates the renin-angiotensin system and induces epithelial-mesenchymal transition in streptozotocin-induced diabetic kidneys.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318803009

5 Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Introduction: The renin-angiotensin system and epithelial-mesenchymal transition play crucial roles in the development of kidney fibrosis. The connection between the renin-angiotensin system and transforming growth factor-β in epithelial-mesenchymal transition remains largely unknown.

Materials And Methods: We assessed oxidative stress, cytokine levels, renal morphology, profibrotic growth factor and renin-angiotensin system component expression, and cell-specific E- and N-cadherin expression in the kidneys of gerbils with streptozotocin-induced diabetes mellitus. Read More

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http://dx.doi.org/10.1177/1470320318803009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166313PMC
January 2019
1 Read

Angiotensin IV suppresses inflammation in the brains of rats with chronic cerebral hypoperfusion.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318799587

1 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, People's Republic of China.

Introduction: This study aimed to evaluate the influence of central angiotensin IV (Ang IV) infusion on chronic cerebral hypoperfusion (CCH)-related neuropathological changes including amyloid-β (Aβ), hyperphosphorylated tau (p-tau) and the inflammatory response.

Materials And Methods: Rats with CCH received central infusion of Ang IV, its receptor ATR antagonist divalinal-Ang IV or artificial cerebrospinal fluid for six weeks. During this procedure, the systolic blood pressure (SBP) was monitored, and the levels of Aβ, p-tau and pro-inflammatory cytokines in the brain were detected. Read More

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http://dx.doi.org/10.1177/1470320318799587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144503PMC
January 2019
1 Read
2.270 Impact Factor

A randomized trial of the efficacy and safety of azilsartan medoxomil combined with chlorthalidone.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318795000

5 Takeda Pharmaceuticals America, Inc., USA.

Introduction: We measured the effects of azilsartan medoxomil co-administered with chlorthalidone 25 mg in stage 2 hypertension.

Methods: Azilsartan medoxomil 40 or 80 mg plus chlorthalidone were compared with placebo plus chlorthalidone once daily in a randomized, double-blind, 6-week trial. The primary endpoint was change from baseline in 24-hour mean systolic blood pressure by ambulatory blood pressure monitoring. Read More

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http://dx.doi.org/10.1177/1470320318795000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122257PMC
January 2019
2 Reads

Orthotopic renal autotransplantation for young-onset and medical treatment-requiring complex renovascular hypertension.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318789861

1 Department of Vascular Surgery, Peking Union Medical Hospital, China.

Objective: In this article, we aim to prove the safety and effectiveness of orthotopic renal autotransplantation using ex vivo repair for the treatment of complex renovascular hypertension (RVH).

Methods: We retrospectively reviewed five consecutive patients (three women, two men) with young-onset RVH from January 2009 to August 2014. Orthotopic renal autotransplantation using ex vivo repair was performed and perioperative data were collected for statistical analysis. Read More

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http://dx.doi.org/10.1177/1470320318789861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104217PMC
January 2019
2 Reads

Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318795001

Department of Ophthalmology, Kagawa University Faculty of Medicine, Japan.

Objective: The purpose of this article is to investigate the relationship between the plasma concentration of aldosterone and changes in the number of retinal ganglion cells (RGCs) after systemic administration of aldosterone.

Methods: An osmotic minipump that was subcutaneously implanted into the midscapular region of rats administered 40, 80 or 160 μg/kg/day aldosterone or vehicle. Enzyme immunoassay kits were used to measure the plasma aldosterone concentrations two weeks after the systemic administration of aldosterone or vehicle. Read More

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http://dx.doi.org/10.1177/1470320318795001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104211PMC
January 2019

Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318789323

1 Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, USA.

Hypothesis: Hyperglycemia decreases angiotensin-(1-7), the endogenous counter-regulator of angiotensin II in the retina.

Materials And Methods: The distribution and levels of retinal angiotensin II (Ang II) and angiotensin-(1-7) (Ang-(1-7)) were evaluated by confocal imaging and quantitative immunohistochemistry during the development of streptozotocin-induced diabetes in rats.

Results: In the nondiabetic eye, Ang II was localized to the endfeet of Müller cells, extending into the cellular processes of the inner plexiform layer and inner nuclear layer; Ang-(1-7) showed a wider distribution, extending from the foot plates of the Müller cells to the photoreceptor layer. Read More

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http://dx.doi.org/10.1177/1470320318789323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104213PMC
January 2019
2 Reads

Age-related changes in vascular responses to angiotensin-(1-7) in female mice.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318789332

2 Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.

The vasodilatory effect of angiotensin-(1-7) seems to vary between sexes, and estradiol (E2) can modulate the magnitude of the Ang-(1-7) vasodilatory response in female rats. However, there are few studies addressing the influence of sex on the age-related vasodilatory effect of Ang-(1-7). Here, we evaluated the vasodilatory response to Ang-(1-7) on vascular ageing. Read More

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http://dx.doi.org/10.1177/1470320318789332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053867PMC
January 2019
5 Reads

Tumour necrosis factor-related apoptosis-inducing ligand expression in patients with diabetic nephropathy.

J Renin Angiotensin Aldosterone Syst 2018 Jul-Sep;19(3):1470320318785744

1 Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, China.

Objective: The objective of this study was to evaluate the expression profile of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in patients with diabetic nephropathy (DN).

Methods: A total of 126 Chinese subjects were enrolled in this study, including 42 patients with diabetes mellitus (DM), 42 patients with DN and 42 healthy controls. Real-time polymerase chain reaction was performed to analyze levels of TRAIL mRNA in peripheral blood mononuclear cells (PBMCs). Read More

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http://dx.doi.org/10.1177/1470320318785744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047249PMC
January 2019
6 Reads
2.271 Impact Factor

Inhibition of renin-angiotensin axis reduces the risk of thrombus formation in the left atrial appendage in patients with hypertension complicated by atrial fibrillation.

J Renin Angiotensin Aldosterone Syst 2018 Apr-Jun;19(2):1470320318782623

1 Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, People's Republic of China.

Aims: We examined whether the use of a renin-angiotensin-aldosterone system (RAS) inhibitor plays a role in protecting against left atrial appendage thrombus (LAAT) in patients with hypertension complicated by atrial fibrillation (AF).

Methods: Two observational studies were conducted on patients with diagnoses of hypertension and AF, who were categorized into RAS inhibitor user or nonuser groups. Demographic characteristics, clinical characteristics, echocardiographic parameters and hemostatic markers were examined and the occurrence of LAAT during follow-up were recorded. Read More

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http://dx.doi.org/10.1177/1470320318782623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077910PMC
October 2018
15 Reads

A pilot investigation into the effects of acute normobaric hypoxia, high altitude exposure and exercise on serum angiotensin-converting enzyme, aldosterone and cortisol.

J Renin Angiotensin Aldosterone Syst 2018 Apr-Jun;19(2):1470320318782782

1 Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, UK.

Introduction: Aldosterone decreases at high altitude (HA) but the effect of hypoxia on angiotensin-converting enzyme (ACE), a key step in the renin-angiotensin-aldosterone system, is unclear.

Methods: We investigated the effects of exercise and acute normobaric hypoxia (NH, ~11.0% FiO) on nine participants and six controls undertaking the same exercise at sea level (SL). Read More

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http://dx.doi.org/10.1177/1470320318782782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077905PMC
October 2018
24 Reads

Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly.

J Renin Angiotensin Aldosterone Syst 2018 Apr-Jun;19(2):1470320318782622

1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil.

Objective: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. Read More

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http://dx.doi.org/10.1177/1470320318782622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024535PMC
October 2018
15 Reads

Sulfur dioxide improves endothelial dysfunction by downregulating the angiotensin II/ATR pathway in D-galactose-induced aging rats.

J Renin Angiotensin Aldosterone Syst 2018 Apr-Jun;19(2):1470320318778898

4 Basic Laboratory, Suining Central Hospital, China.

The aim of this study was to investigate the protective effects of sulfur dioxide (SO) on the endothelial function of the aorta in D-galactose (D-gal)-induced aging rats. Sprague Dawley rats were randomized into a D-gal group, a D-gal + SO group and a control group, then injected with D-gal, D-gal + SO donor or equivalent volumes of saline, respectively, for 8 consecutive weeks. After 8 weeks, the mean arterial pressure was significantly increased in the D-gal group, but was lowered by SO. Read More

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http://dx.doi.org/10.1177/1470320318778898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985551PMC
October 2018
9 Reads
2.270 Impact Factor

Association of angiotensin-converting enzyme gene I/D polymorphism with chronic obstructive pulmonary disease: a meta-analysis.

J Renin Angiotensin Aldosterone Syst 2018 Apr-Jun;19(2):1470320318770546

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, China.

Objectives: We conducted a meta-analysis of published studies on the angiotensin-converting enzyme ( ACE) gene insertion/deletion (I/D) polymorphism associated with the risk of chronic obstructive pulmonary disease, as well as with pulmonary function and circulating angiotensin-converting enzyme changes.

Methods: A literature search, quality assessment and data extraction were completed independently and in duplicate.

Results: A total of 16 articles were meta-analysed, including 12 articles (2113 patients and 8786 controls) for chronic obstructive pulmonary disease risk and eight articles (11,664 subjects) for pulmonary and circulating phenotypes. Read More

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http://dx.doi.org/10.1177/1470320318770546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954319PMC
October 2018
5 Reads

Aerobic exercise training differentially affects ACE C- and N-domain activities in humans: Interactions with ACE I/D polymorphism and association with vascular reactivity.

J Renin Angiotensin Aldosterone Syst 2018 Apr-Jun;19(2):1470320318761725

1 School of Physical Education and Sport, University of São Paulo, Brazil.

Introduction: Previous studies have linked angiotensin-converting enzyme ( ACE) insertion (I)/deletion (D) polymorphism (II, ID and DD) to physical performance. Moreover, ACE has two catalytic domains: NH2 (N) and COOH (C) with distinct functions, and their activity has been found to be modulated by ACE polymorphism. The aim of the present study is to investigate the effects of the interaction between aerobic exercise training (AET) and ACE I/D polymorphism on ACE N- and C-domain activities and vascular reactivity in humans. Read More

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http://dx.doi.org/10.1177/1470320318761725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894927PMC
October 2018
8 Reads

Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-β signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis.

J Renin Angiotensin Aldosterone Syst 2018 Jan-Mar;19(1):1470320318759358

1 Department of Pathology, Dalhousie University, Halifax, NS, Canada.

Introduction: Transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) are often described as the initial pro-fibrotic mediators upregulated early in fibrosis models dependent on angiotensin II (Ang-II). In the present study, we explore the mechanistic link between TGF-β and CTGF expression by using a novel TGF-β trap.

Materials And Methods: NIH/3T3 fibroblasts were subjected to TGF-β with or without TGF-β trap or 1D11 antibody, CTGF or CTGF plus TGF-β for six or 24 hours, and then used for quantitative real-time polymerase chain reaction (qRT-PCR) or immunocytochemistry. Read More

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http://dx.doi.org/10.1177/1470320318759358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888824PMC
September 2018
5 Reads

A randomized intervention study to evaluate the effect of calcitriol therapy on the renin-angiotensin system in diabetes.

J Renin Angiotensin Aldosterone Syst 2018 Jan-Mar;19(1):1470320317754178

1 Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.

Background: Prior studies suggest that vitamin D therapy may decrease cardiovascular disease risk in type 2 diabetes (T2DM) by lowering renin-angiotensin system (RAS) activity. However, randomized human intervention studies to evaluate the effect of vitamin D receptor (VDR) agonists on RAS activity are lacking.

Objective: The objective of this article is to investigate the effect of direct VDR activation with calcitriol on circulating RAS activity and vascular hemodynamics in T2DM. Read More

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http://dx.doi.org/10.1177/1470320317754178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896865PMC
September 2018
2 Reads

The relationship between ACE/AGT gene polymorphisms and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes.

J Renin Angiotensin Aldosterone Syst 2018 Jan-Mar;19(1):1470320317752955

1 Department of Immunology, Xiangya School of Medicine, Central South University, China.

Aims: This study aims to investigate the association between renin-angiotensin system gene polymorphism and diabetic retinopathy (DR) in Chinese patients with type 2 diabetes.

Methods: We consecutively included 1491 patients for the assessment of ACE I/D and AGT M/T gene polymorphisms in 345 DR cases and 1146 patients without retinopathy (DNR). Albuminuria was defined by urine albumin creatinine ratio and albumin excretion rate. Read More

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http://journals.sagepub.com/doi/10.1177/1470320317752955
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http://dx.doi.org/10.1177/1470320317752955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843891PMC
September 2018
8 Reads

Irbesartan prevents sodium channel remodeling in a canine model of atrial fibrillation.

J Renin Angiotensin Aldosterone Syst 2018 Jan-Mar;19(1):1470320318755269

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, China.

Introduction: Activation of the renin-angiotensin system (RAS) plays an important role in atrial electrical remodeling (AER). The purpose of the present study was to evaluate the effects of irbesartan on cardiac sodium current (I) in a canine model of atrial fibrillation.

Materials And Methods: Eighteen dogs were randomized into sham, pacing or pacing+irbesartan groups ( n = 6 in each group). Read More

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http://dx.doi.org/10.1177/1470320318755269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843850PMC
September 2018
4 Reads

Contribution of angiotensinogen M235T and T174M gene variants and haplotypes to preeclampsia and its severity in (North African) Tunisians.

J Renin Angiotensin Aldosterone Syst 2018 Jan-Mar;19(1):1470320317753924

1 Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), College of Pharmacy, University of Monastir, Tunisia.

Background: Preeclampsia (PE) is a pregnancy-associated hypertensive disorder and a leading cause of maternal and neonatal morbidity and mortality. While its pathogenesis remains ill defined, several candidate genes for PE have been identified, but results remain inconclusive. We investigated the association of the angiotensinogen ( AGT) gene variants M235T and T174M with PE, and we analyzed the contribution of both variants to the severity of PE. Read More

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http://dx.doi.org/10.1177/1470320317753924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843851PMC
September 2018
16 Reads
2.271 Impact Factor

Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis.

J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317741066

Department of Preventive Medicine, Wannan Medical College, China.

Objective: The results of studies on the association between tumor necrosis factor-a -308G/A (TNF-a -308G/A) polymorphism, and susceptibility to essential hypertension are controversial. To derive a more precise estimation, we conducted a meta-analysis of all similar articles.

Methods: The summary effect odds ratios and 95% confidence intervals were obtained. Read More

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http://dx.doi.org/10.1177/1470320317741066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843847PMC
July 2018
4 Reads

Haplotype-based association of renin gene polymorphisms with essential hypertension in Han population of northern china.

J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317744917

2 Institute of Polygenic Disease, Qiqihar Medical University, China.

Introduction: The renin gene has been suggested as a good candidate in the study of genetic mechanism of essential hypertension. However, studies on the contribution of renin gene polymorphisms to essential hypertension, have not had consistent outcomes. The purpose of the present study is to explore the association of renin gene polymorphisms with essential hypertension in the Han population of northern China. Read More

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http://dx.doi.org/10.1177/1470320317744917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843929PMC
July 2018
4 Reads

Association of the genetic and traditional risk factors of ischaemic heart disease with STEMI and NSTEMI development.

J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317739987

1 Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania.

Introduction: To evaluate the influence of traditional risk factors of ischaemic heart disease and genetic factors to predict different types of acute coronary syndromes.

Materials And Methods: Five hundred and twenty-three patients with acute coronary syndromes (393 with ST elevation myocardial infarction (STEMI) and 130 with non-ST elevation myocardial infarction (NSTEMI)) comprised the study group. The control group consisted of 645 subjects free from symptoms of ischaemic heart disease and stroke. Read More

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http://dx.doi.org/10.1177/1470320317739987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843915PMC
July 2018
15 Reads

A case report of hyponatremia after surgery for Conn's adenoma.

J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317740240

1 Department of Medical Sciences, University of Trieste, Italy.

Primary aldosteronism (PA), also known as Conn's syndrome, is a frequent cause of secondary hypertension. If PA is due to a documented unilateral adrenal adenoma, adrenalectomy is the treatment of choice. Endocrine Society guidelines suggest monitoring potassium after adrenalectomy, while there is no mention of sodium disorders after surgery. Read More

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http://dx.doi.org/10.1177/1470320317740240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843937PMC
July 2018
12 Reads

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism.

J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317737184

Department of Veterinary Clinical Sciences, North Carolina State University, USA.

Objective: The objective of this study was to evaluate angiotensin-converting enzyme (ACE) activity in dogs and with and without an ACE polymorphism in the canine ACE gene, before and after treatment with an ACE inhibitor.

Methods: Thirty-one dogs (20 wild-type, 11 ACE polymorphism) with heart disease were evaluated with ACE activity measurement and systolic blood pressure before and after administration of an ACE inhibitor (enalapril).

Results: Median pre-treatment ACE activity was significantly lower for ACE polymorphism dogs than for dogs with the wild-type sequence ( P=0. Read More

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http://dx.doi.org/10.1177/1470320317737184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843865PMC
July 2018
21 Reads

Aldosterone breakthrough does not alter central hemodynamics.

J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317735002

Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA.

Introduction: Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are widely used in congestive heart failure and chronic kidney disease, but up to 40% of patients will experience aldosterone breakthrough, with aldosterone levels rising above pre-treatment levels after 6-12 months of renin-angiotensin-aldosterone system blockade. Aldosterone breakthrough has been associated with worsening congestive heart failure and chronic kidney disease, yet the pathophysiology remains unclear. Breakthrough has not been associated with elevated peripheral blood pressure, but no studies have assessed its effect on central blood pressure. Read More

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http://dx.doi.org/10.1177/1470320317735002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843861PMC
July 2018
4 Reads

Effect of unilateral nephrectomy on urinary angiotensinogen levels in living kidney donors: 1 year follow-up study.

J Renin Angiotensin Aldosterone Syst 2017 Oct-Dec;18(4):1470320317734082

1 Department of Nephrology, Ankara University School of Medicine, Turkey.

Background: Urinary angiotensinogen (uAGT) has recently been proposed as a marker of kidney injury and activated intrarenal renin-angiotensin system. We investigated the effects of living donor nephrectomy on uAGT levels, blood pressure, estimated glomerular filtration rate, proteinuria and compensatory hypertrophy in the remaining kidney of living kidney donors.

Methods: Twenty living kidney donors were included in the study and followed for 1 year. Read More

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http://dx.doi.org/10.1177/1470320317734082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843895PMC
July 2018
7 Reads

Adipocytes do not significantly contribute to plasma angiotensinogen.

J Renin Angiotensin Aldosterone Syst 2016 Oct-Dec;17(4):1470320316672348

3 Institute of Medical Sciences, Tokai University, Japan.

Recently, it has been reported that 25% of plasma angiotensinogen (Agt) is derived from fat. Meanwhile, liver-specific Agt knockout (KO) mice have markedly low plasma Agt, which may be due to reduced fat mass. To study the contribution of the fat to plasma Agt, we tested whether increasing fat mass can elevate plasma Agt and blood pressure in liver- Agt KO mice. Read More

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http://dx.doi.org/10.1177/1470320316672348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843855PMC
January 2018
3 Reads

Angiotensin-(1-7) attenuates atrial tachycardia-induced sympathetic nerve remodeling.

J Renin Angiotensin Aldosterone Syst 2017 Jul-Sep;18(3):1470320317729281

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, China.

Introduction: The effect of Angiotensin-(1-7) (Ang-(1-7)) on atrial autonomic remodeling is still unknown. We hypothesized that Ang-(1-7) could inhibit sympathetic nerve remodeling in a canine model of chronic atrial tachycardia.

Materials And Methods: Eighteen dogs were randomly assigned to sham group, pacing group and Ang-(1-7) group. Read More

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http://dx.doi.org/10.1177/1470320317729281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843893PMC
July 2018
8 Reads

Plasma renin activity in patients with heart failure and reduced ejection fraction on optimal medical therapy.

J Renin Angiotensin Aldosterone Syst 2017 Jul-Sep;18(3):1470320317729919

1 Department of Cardiology, Ziekenhuis Oost-Limburg, Belgium.

Background: Renin-angiotensin-aldosterone system (RAAS) activation in heart failure with reduced ejection fraction (HFREF) is detrimental through promotion of ventricular remodeling and salt and water retention.

Aims: The aims of this article are to describe RAAS activity in distinct HFREF populations and to assess its prognostic impact.

Methods: Venous blood samples were prospectively obtained in 76 healthy volunteers, 72 patients hospitalized for acute decompensated HFREF, and 78 ambulatory chronic HFREF patients without clinical signs of congestion. Read More

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http://dx.doi.org/10.1177/1470320317729919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843922PMC
July 2018
9 Reads

LY3045697: Results from two randomized clinical trials of a novel inhibitor of aldosterone synthase.

J Renin Angiotensin Aldosterone Syst 2017 Jul-Sep;18(3):1470320317717883

4 Division of Endocrinology, Skagit Regional Health, USA.

Introduction: LY3045697 is a potent and selective aldosterone synthase (CYP11B2) inhibitor that was developed as a safer alternative to mineralocorticoid receptor antagonists. Effects of LY3045697 on aldosterone and cortisol synthesis, as well as potassium ion homeostasis, were evaluated in two clinical studies in healthy subjects.

Materials And Methods: Two incomplete, placebo-controlled crossover-design clinical studies examined safety, pharmacodynamics, and pharmacokinetics under single and repeated dose conditions in healthy subjects. Read More

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http://dx.doi.org/10.1177/1470320317717883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843917PMC
July 2018
28 Reads

Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2.

J Renin Angiotensin Aldosterone Syst 2017 Jul-Sep;18(3):1470320317722270

2 The Department of Anesthesiology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Background: Diastolic dysfunction develops in response to hypertension and estrogen (E2) loss and is a forerunner to heart failure (HF) in women. The cardiac renin-angiotensin system (RAS) contributes to diastolic dysfunction, but its role with respect to E2 and blood pressure remain unclear.

Methods: We compared the effects of ovariectomy (OVX) or sham surgery on the cardiac RAS, left ventricular (LV) structure/function, and systemic/intracardiac pressures of spontaneously hypertensive rats (SHRs: n = 6 intact and 6 OVX) and age-matched Wistar-Kyoto (WKY: n = 5 intact and 4 OVX) controls. Read More

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http://dx.doi.org/10.1177/1470320317722270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805468PMC
July 2018
52 Reads

Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma.

J Renin Angiotensin Aldosterone Syst 2017 Jul-Sep;18(3):1470320317717904

7 Department of Hematology-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.

Introduction: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. Read More

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http://dx.doi.org/10.1177/1470320317717904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843911PMC
July 2018
8 Reads

The mTOR/p70S6K1 signaling pathway in renal fibrosis of children with immunoglobulin A nephropathy.

J Renin Angiotensin Aldosterone Syst 2017 Jul-Sep;18(3):1470320317717831

1 Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China.

Aim: The purpose of this study was to explore whether mTOR/p70S6K1 signaling is activated in renal fibrosis of immunoglobulin A nephropathy.

Methods: Seventy-two children with immunoglobulin A nephropathy were divided into three groups according to their clinical features and pathological grades. Six normal renal specimens were included in the control group. Read More

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http://dx.doi.org/10.1177/1470320317717831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843880PMC
July 2018
12 Reads

Will the recent hypertension trials change the guidelines?

Authors:
Peter Sever

J Renin Angiotensin Aldosterone Syst 2017 Apr-Jun;18(2):1470320317710891

International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, UK.

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http://dx.doi.org/10.1177/1470320317710891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843860PMC
July 2017
3 Reads

Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism.

J Renin Angiotensin Aldosterone Syst 2017 Apr-Jun;18(2):1470320317703451

1 Department of Biophysics, Federal University of São Paulo, Brazil.

Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents.

Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Read More

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http://dx.doi.org/10.1177/1470320317703451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843858PMC
March 2018
36 Reads