3,144 results match your criteria Journal of the Mechanical Behavior of Biomedical Materials [Journal]


Incorporation of dimethyl sulfoxide to model adhesive resins with different hydrophilicities: Physico/mechanical properties.

J Mech Behav Biomed Mater 2019 Feb 14;93:143-150. Epub 2019 Feb 14.

Department of Cariology and Restorative Dentistry, Institute of Dentistry, University of Turku, Turku, Finland; Adhesive Dentistry Research Group, Biomaterials and Medical Device Research Program, Biocity, Turku, Finland; Turku University Hospital, TYKS, University of Turku, Turku, Finland.

Objective: To understand dimethyl sulfoxide (DMSO) interaction with distinct methacrylate monomer blends and the impact on polymer formation by investigating the combined relationship among degree of resin hydrophilicity, presence of DMSO and specific physico/mechanical properties.

Methods: One hydrophobic (R2) and one hydrophilic (R5) methacrylate-based resins with different monomer compositions were solvated in ascending DMSO concentrations (0, 0.01, 0. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.015DOI Listing
February 2019

Polydimethylsiloxane and poly(ether) ether ketone functionally graded composites for biomedical applications.

J Mech Behav Biomed Mater 2019 Feb 12;93:130-142. Epub 2019 Feb 12.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.

Functionally graded materials (FGMs), with varying spatial, chemical and mechanical gradients (continuous or stepwise), have the potential to mimic heterogenous properties found across biological tissues. They can prevent stress concentrations and retain healthy cellular functions. Here, we show for the first time the fabrication of polydimethylsiloxane and poly(ether) ether ketone (PDMS-PEEK) composites. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.012DOI Listing
February 2019

In situ probing of switchable nanomechanical properties of responsive high-density polymer brushes on poly(dimethylsiloxane): An AFM nanoindentation approach.

J Mech Behav Biomed Mater 2019 Feb 6;93:118-129. Epub 2019 Feb 6.

Institute of Polymeric Materials, Sahand University of Technology, P.O.Box 51335-1996, Tabriz, Iran; Faculty of Polymer Engineering, Sahand University of Technology, Tabriz, Iran.

Nanomechanical characteristics of end grafted polymer brushes were studied by AFM based, colloidal probe nanoindentation measurements. A high-density polymer brush of poly(2-hydroxyethyl methacrylate) (PHEMA) was precisely prepared on the surface of a flexible poly(dimethylsiloxane) (PDMS) substrate oxidized in ultraviolet/ozone (UVO). Exposure times less than 10min resulted in laterally homogeneous oxidized surfaces, characterized by a SiO thickness ∼35nm and an increased modulus up to 9MPa, as shown by AFM nanoindentation measurements. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.002DOI Listing
February 2019

Effects of the addition of boron nitride nanoplate on the fracture toughness, flexural strength, and Weibull Distribution of hydroxyapatite composites prepared by spark plasma sintering.

J Mech Behav Biomed Mater 2019 Jan 31;93:105-117. Epub 2019 Jan 31.

Mechanical Engineering Department, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:

Hydroxyapatite (HA) has inherently low fracture toughness and low flexural strength, thus limiting it from wide scale application as an implant material in the biomedical field. To increase the fracture toughness and flexural strength, HA composites were fabricated by adding boron nitride nanoplatelets (BNNP) as reinforcement. Spark plasma sintering was utilized to achieve fine grain structure. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.021DOI Listing
January 2019

A fast degrading PLLA composite with a high content of functionalized octacalcium phosphate mineral phase induces stem cells differentiation.

J Mech Behav Biomed Mater 2019 Feb 6;93:93-104. Epub 2019 Feb 6.

Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Octacalcium phosphate (OCP) was synthesized yielding a combination of OCP and hydroxyapatite (HA) with a ratio of 90:10 (OCP/HA). A method was developed to functionalize the surface of the apatite using lauroyl chloride to improve the dispersion of the mineral phase in a poly(L-lactide) (PLLA) polymeric matrix. Infrared spectra and thermal gravimetric analysis confirmed the presence of laurate on the surface of calcium phosphate (CaP) particles. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.003DOI Listing
February 2019

Material anisotropy and elasticity of cortical and trabecular bone in the adult mouse femur via AFM indentation.

J Mech Behav Biomed Mater 2019 Jan 31;93:81-92. Epub 2019 Jan 31.

Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, Montreal, QC, Canada H3A 0C3. Electronic address:

This paper investigates the elastic properties of bone tissue in the adult mouse femur through Atomic Force Microscopy (AFM) indentation with the goal of understanding its microstructure and underlying mechanics at the nano length scale. Both trabecular and cortical bone types are studied. In particular, we examined the elasticity of cortical bone and individual trabeculae in the longitudinal and transverse directions of the samples. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.024DOI Listing
January 2019

Theoretical analysis of nanoshell-assisted thermal treatment for subcutaneous tumor.

J Mech Behav Biomed Mater 2019 Feb 1;93:70-80. Epub 2019 Feb 1.

CAS Key Laboratory of Mechanical Behavior and Design of Materials, University of Science and Technology of China, Hefei, Anhui 230027, PR China.

The hyperthermia is an efficient technique for tumor treatment, in which the tumor is subjected to a heating source, such as laser, supersonic or electromagnetic field. In order to improve the therapeutic efficiency and to protect the surrounding healthy tissues, gold nanoshells are embedded in the tumor as the additive to make it absorb more thermal energy than the healthy tissues. In the present study, a one-dimensional three-layered model is established to investigate the thermal response of the bio-tissue in the hyperthermia treatment for subcutaneous tumor. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.016DOI Listing
February 2019

Atomic force microscopy-indentation demonstrates that alginate beads are mechanically stable under cell culture conditions.

J Mech Behav Biomed Mater 2019 Jan 30;93:61-69. Epub 2019 Jan 30.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus off Roosevelt Drive, OX3 7DQ, United Kingdom. Electronic address:

Alginate microbeads are extensively used in tissue engineering as microcarriers and cell encapsulation vessels. In this study, we used atomic force microscopy (AFM) based indentation using 20 µm colloidal probes to assess the local reduced elastic modulus (E * ) using a novel method to detect the contact point based on the principle of virtual work, to measure microbead mechanical stability under cell culture conditions for 2 weeks. The bead diameter and swelling were assessed in parallel. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.019DOI Listing
January 2019
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Development and characterization of biological bovine dentin posts.

J Mech Behav Biomed Mater 2019 Jan 30;92:197-205. Epub 2019 Jan 30.

Analytical Laboratory of Restorative Biomaterials - LABiom-R, Universidade Federal Fluminense / Faculdade de Odontologia - Rua Mário Santos Braga, n° 30 - Campus Valonguinho, Centro CEP 24040-110, Niterói, RJ, Brazil. Electronic address:

This study aimed at evaluating the use of biological dentin post (BDP), achieved by milling bovine root, through the analyses of mechanical and optical properties. BDPs were compared to a glass fiber post (GFP) in the following tests (n = 10): a) elastic modulus (E) and flexural resistance (σ) by three point bending test; b) fracture resistance (FR) by compressive load at 45° and failure pattern; c) light transmitting (LT) ability and their influence on the resin cement's degree of conversion (DC%); d) bond strength (BS) by push-out test and failure pattern. Bovine teeth were decoronated and root length was standardized at 14 mm. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.018DOI Listing
January 2019

Assessment of PCL/carbon material scaffolds for bone regeneration.

J Mech Behav Biomed Mater 2019 Jan 31;93:52-60. Epub 2019 Jan 31.

School of Mechanical, Aerospace and Civil Engineering, The University of Manchester, Manchester M13 9PL, UK. Electronic address:

Biomanufacturing is a relatively new research domain focusing on the use of additive manufacturing technologies, biomaterials, cells and biomolecular signals to produce tissue constructs for tissue engineering. For bone regeneration, researchers are focusing on the use of polymeric and polymer/ceramic scaffolds seeded with osteoblasts or mesenchymal stem cells. However, the design of high-performance scaffolds in terms of mechanical, cell-stimulation and biological performance is still required. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.020DOI Listing
January 2019

A noninvasive MRI based approach to estimate the mechanical properties of human knee ligaments.

J Mech Behav Biomed Mater 2019 Feb 7;93:43-51. Epub 2019 Feb 7.

Orthopaedic Research Lab, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; Laboratory of Biomechanical Engineering, University of Twente, Enschede, the Netherlands.

Characterization of the main tibiofemoral ligaments is an essential step in developing patient-specific computational models of the knee joint for personalized surgery pre-planning. Tensile tests are commonly performed in-vitro to characterize the mechanical stiffness and rupture force of the knee ligaments which makes the technique unsuitable for in-vivo application. The time required for the limited noninvasive approaches for properties estimation based on knee laxity remained the main obstacle in clinical implementation. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.022DOI Listing
February 2019

Hydro air abrasion on dental glass-ceramics: A direct 3D analysis by stylus profilometry.

J Mech Behav Biomed Mater 2019 Feb 4;93:36-42. Epub 2019 Feb 4.

DISC Department, Genoa Dental School, Genoa University, Italy.

Air abrasion is used in dentistry for cavity opening, post-endodontic cavity cleaning, and removal of hard deposits or stains. Different applications may require different settings. We aimed to gain better understanding of the effect of some operating parameters on the efficiency of air abrasion on a model dental material. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.005DOI Listing
February 2019

Corrosion and metal release from overlapping arterial stents under mechanical and electrochemical stress - An experimental study.

J Mech Behav Biomed Mater 2019 Feb 4;93:31-35. Epub 2019 Feb 4.

Department of Clinical Science, Faculty of Medicine, University of Bergen, N-5021 Bergen, Norway; Department of Vascular Surgery, Haukeland University Hospital, Norway.

Intra-arterial stenosis due to atherosclerosis is often treated with endovascular balloon dilatation with a metal stent. Restenosis is common and is frequently treated with a new stent placed inside the existing one or the stents are placed with overlap to cover a larger area of the vessels. Observations of stent fractures, stent compression, accumulation of immunocompetent cells around stents have suggested the possibility of immunologic reactions to substances released from stents. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.001DOI Listing
February 2019
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Structural, chemical and mechanical study of TiAlV film on UHMWPE produced by DC magnetron sputtering.

J Mech Behav Biomed Mater 2019 Jan 12;93:23-30. Epub 2019 Jan 12.

Cátedras-CONACyT, Universidad de Guadalajara-CUCEI, Guadalajara, Jalisco, México. Electronic address:

Ultra High Molecular Weight Polyethylene (UHMWPE), with a semi-trapezoidal topography, and glass samples were coated with a TiAlV film using magnetron sputtering in order to study its structure, chemical composition and the adhesion film properties on the polymer surfaces. The magnetron sputtering is a PVD technique that depending on the deposited parameter produces a coating with structural, chemical and specific topographic characteristics that increase the electrical, mechanical, optical and biological surface properties of the organic compounds. The quantities of Vanadium (V) and Aluminum (Al) were similar to that of Ti64 alloy. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.010DOI Listing
January 2019
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Finite element simulation of three dimensional residual stress in the aortic wall using an anisotropic tissue growth model.

J Mech Behav Biomed Mater 2019 Jan 16;92:188-196. Epub 2019 Jan 16.

Tissue Mechanics Laboratory, The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30313-2412, United States. Electronic address:

Residual stress is believed to play a significant role in the in vivo stress state of the arterial wall, but quantifying residual stress in vivo is challenging. Based on the well-known assumptions that residual stress is a result of heterogeneous arterial growth and that it homogenizes the transmural distribution of arterial wall stress, we propose a new anisotropic tissue growth model for the aorta to recover the three-dimensional residual stress field in a bi-layer human aortic wall. Finite element simulations showed that the predicted residual stress magnitude with this method are within the documented range for human aorta. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.007DOI Listing
January 2019

Mechanical behavior of metastatic femurs through patient-specific computational models accounting for bone-metastasis interaction.

J Mech Behav Biomed Mater 2019 Jan 30;93:9-22. Epub 2019 Jan 30.

Department of Orthopaedics and Trauma Surgery, Campus Bio-Medico University of Rome, Italy.

This paper proposes a computational model based on a finite-element formulation for describing the mechanical behavior of femurs affected by metastatic lesions. A novel geometric/constitutive description is introduced by modelling healthy bone and metastases via a linearly poroelastic constitutive approach. A Gaussian-shaped graded transition of material properties between healthy and metastatic tissues is prescribed, in order to account for the bone-metastasis interaction. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.014DOI Listing
January 2019
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The effects of surface treatments on tensile bond strength of polyether-ketone-ketone (PEKK) to veneering resin.

J Mech Behav Biomed Mater 2019 Jan 30;93:1-8. Epub 2019 Jan 30.

Dental Materials Science, Discipline of Applied Oral Sciences, Faculty of Dentistry, the University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong Special Administrative Region. Electronic address:

Objectives: To test the different PEKK surface treatment methods on the tensile bond strength (TBS) of a resin composite to PEKK.

Methods: Two hundred and fifty polished PEKK specimens were fabricated, divided into 5 groups (n = 50) and underwent the following treatments: no pre-treatment (control group C), 110 µm AlO gritblasting at 2 bar for 10 s (Group Al), 98 wt% sulfuric acid etching for 60 s (Group SA), tribochemical silica-coating through air-abrasion with Rocatec Plus 110 µm at 2 bar for 10 s (Group Trib), and sulfuric acid etching and subsequent tribochemical silica-coating (Group SATrib). Ten specimens in each group were taken out for surface characterization. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.015DOI Listing
January 2019

Tough robust dual responsive nanocomposite hydrogel as controlled drug delivery carrier of asprin.

J Mech Behav Biomed Mater 2019 Jan 30;92:179-187. Epub 2019 Jan 30.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.

Smart mechanical strong hydrogels have gained increasing attention in the last decade. A novel tough robust biocompatible and dual pH- and temperature- responsive poly (N-isopropylacrylamide)/clay (Laponite XLS)/gold nanoparticles (Au-S-S NPs)/caboxymethyl chitosan (CMCTs) nanocomposite hydrogel was synthesized by a facile one-pot in situ free radical polymerization, using clay and Au-S-S NPs as the cross-linkers instead of toxic organic molecules. By tuning the crucial factors, concentration of Au-S-S NPs, CMCTs and clay, the obtained hydrogels exhibited the highest tensile stress of 535. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.017DOI Listing
January 2019

In vivo adhesive behavior of human facial skin by a modified indentation test.

J Mech Behav Biomed Mater 2019 Jan 26;92:172-178. Epub 2019 Jan 26.

Department of Mechanics, Tianjin University, Tianjin 300350, China.

A better understanding of the adhesive behavior of human facial skin is important for dermatological or cosmetic applications. For their in vivo experimental characterization and analysis, the indentation test is an effective and widely used method. In this study, our independently developed transparent indenter and curved surface optical imaging technique are improved, by which the contact area of facial skin can be in vivo and in situ obtained during an indentation test. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.013DOI Listing
January 2019
1 Read

Porous and biodegradable polycaprolactone-borophosphosilicate hybrid scaffolds for osteoblast infiltration and stem cell differentiation.

J Mech Behav Biomed Mater 2019 Jan 15;92:162-171. Epub 2019 Jan 15.

Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON, Canada N6A 5B9; School of Biomedical Engineering, The University of Western Ontario, London, ON, Canada N6A 5B9. Electronic address:

The composition and microstructure of bone tissue engineering scaffolds play a significant role in regulating cell infiltration, proliferation, differentiation, and extracellular matrix production. While boron is an essential trace element for bone formation, growth, and health, boron-containing biomaterials are poorly studied. Specifically, the effect of boron in hybrid scaffolds on stem cell differentiation is unknown. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.011DOI Listing
January 2019
1 Read

Multi-modal characterization of polymeric gels to determine the influence of testing method on observed elastic modulus.

J Mech Behav Biomed Mater 2019 Jan 10;92:152-161. Epub 2019 Jan 10.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 Eighth St., Troy, NY 12180, USA. Electronic address:

Demand for materials that mechanically replicate native tissue has driven development and characterization of various new biomaterials. However, a consequence of materials and characterization technique diversity is a lack of consensus within the field, with no clear way to compare values measured via different modalities. This likely contributes to the difficulty in replicating findings across the research community; recent evidence suggests that different modalities do not yield the same mechanical measurements within a material, and direct comparisons cannot be made across different testing platforms. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.003DOI Listing
January 2019

Wear of ceramic-based dental materials.

J Mech Behav Biomed Mater 2019 Jan 12;92:144-151. Epub 2019 Jan 12.

Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

An investigation is made of wear mechanisms in a suite of dental materials with a ceramic component and tooth enamel using a laboratory test that simulates clinically observable wear facets. A ball-on-3-specimen wear tester in a tetrahedral configuration with a rotating hard antagonist zirconia sphere is used to produce circular wear scars on polished surfaces of dental materials in artificial saliva. Images of the wear scars enable interpretation of wear mechanisms, and measurements of scar dimensions quantify wear rates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161183173
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http://dx.doi.org/10.1016/j.jmbbm.2019.01.009DOI Listing
January 2019
2 Reads

Friction in the contact between skin and a soft counter material: Effects of hardness and surface finish.

J Mech Behav Biomed Mater 2019 Jan 10;92:137-143. Epub 2019 Jan 10.

Department of Mechanical Engineering, Imperial College London, United Kingdom. Electronic address:

The interaction behaviour of skin with a counter surface depends strongly on the surface roughness of the counter surface. For relatively hard surfaces this effect is described in various literature, but for soft, or compliant, materials this is much less studied. Inside the contact, the protuberances on the surface will deform substantially. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.006DOI Listing
January 2019
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Shape recovery strain and nanostructures on recovered polyurethane films and their regulation to osteoblasts morphology.

J Mech Behav Biomed Mater 2019 Jan 11;92:128-136. Epub 2019 Jan 11.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Lab for Smart & Bioinspired Materials, College of Bioengineering, Chongqing University, Chongqing 400045, China. Electronic address:

Shape memory polyurethanes (SMPUs) have emerged as novel dynamic substrates to regulate cell alignment, in which recovery-induced change in substrates topography has been described as the major contributor. This work, for the first time, confirmed the pivotal roles of recovery strain and phase-separated nanostructures of SMPUs in regulating cell morphology. SMPU films with different stretching ratios (0%, 50%, 100%, and 200%) were found to produce an average recovery strain from 19. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.008DOI Listing
January 2019
1 Read

The role of bacterial biofilm and mechanical forces in modulating dental implant failures.

J Mech Behav Biomed Mater 2019 Jan 17;92:118-127. Epub 2019 Jan 17.

Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080, United States. Electronic address:

Currently many assume that bacteria are the primary etiological factor associated with failure of titanium dental implants. However, emerging data indicates a possible role for mechanical forces in implant failure. This study is based on the hypothesis that the synergistic effect of mechanical forces and bacterial biofilm can lead to surface damage resulting in in vivo release of metallic particles. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.012DOI Listing
January 2019
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Developing functionally graded PVA hydrogel using simple freeze-thaw method for artificial glenoid labrum.

J Mech Behav Biomed Mater 2019 Mar 26;91:406-415. Epub 2018 Dec 26.

Medical Devices Technology Centre (Meditec), Faculty of Engineering, School of Biomedical Engineering & Health Sciences, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia. Electronic address:

Intact glenoid labrum is one of passive stabilizer for glenohumeral joint, which have various stiffness at different region. The aim of this study is to develop new artificial glenoid labrum from Polyvinyl Alcohol (PVA) hydrogel, which known as good biomaterial due to its biocompatibility and ability to tailor its modulus. PVA hydrogel was formed using freeze-thaw (FT) method and the stiffness of PVA was controlled by manipulating the concentration of PVA and number of FT cycles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161183110
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http://dx.doi.org/10.1016/j.jmbbm.2018.12.033DOI Listing
March 2019
1 Read

Multiscale modeling of skeletal muscle tissues based on analytical and numerical homogenization.

J Mech Behav Biomed Mater 2018 Dec 27;92:97-117. Epub 2018 Dec 27.

LMS, CNRS, École Polytechnique, Université Paris-Saclay, 91128 Palaiseau, France. Electronic address:

A novel multiscale modeling framework for skeletal muscles based on analytical and numerical homogenization methods is presented to study the mechanical muscle response at finite strains under three-dimensional loading conditions. First an analytical microstructure-based constitutive model is developed and numerically implemented in a general purpose finite element program. The analytical model takes into account explicitly the volume fractions, the material properties, and the spatial distribution of muscle's constituents by using homogenization techniques to bridge the different length scales of the muscle structure. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.030DOI Listing
December 2018
1 Read

Effect of epigallocatechin-3- gallate solutions on bond durability at the adhesive interface in caries-affected dentin.

J Mech Behav Biomed Mater 2019 Mar 30;91:398-405. Epub 2018 Nov 30.

São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo, Brazil. Electronic address:

Hydrolytic and enzymatic degradation by matrix metalloproteinases (MMPs) reduces the durability of composite resin restorations on caries-affected dentin (CAD). The use of MMP inhibitors such as epigallocatechin-3-gallate (EGCG) could increase the longevity of the bond to dentin. This study aimed to evaluate the use of EGCG at different aqueous concentrations on the resin-dentin microtensile bond strength (μTBS), fracture pattern and nanoleakage (NL) in immediate (IM) time interval and after 12-months of water storage (1Y) when using a two-step etch-and-rinse adhesive system on CAD. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.11.022DOI Listing
March 2019
1 Read

Mechanical properties and microstructure of Ti-Mn alloys produced via powder metallurgy for biomedical applications.

J Mech Behav Biomed Mater 2019 Mar 8;91:391-397. Epub 2018 Dec 8.

Waikato Centre for Advanced Materials, School of Engineering, The University of Waikato, Hamilton 3240, New Zealand.

Titanium and especially its alloys are highly employed materials in biomedical applications because of their balanced mechanical properties and biocompatibility. Ti-Mn alloys (1, 5, and 10 wt%. Mn) were produced by powder metallurgy as a potential alternative material for biomedical applications. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.005DOI Listing

PVA-gelatin hydrogels formed using combined theta-gel and cryo-gel fabrication techniques.

J Mech Behav Biomed Mater 2019 Jan 7;92:90-96. Epub 2019 Jan 7.

Department of Mechanical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT 05405, USA; Bioengineering Program, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT 05405, USA; Department of Electrical and Biomedical Engineering, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT 05405, USA; Materials Science Program, Graduate College, University of Vermont, Burlington, VT 05405, USA. Electronic address:

Poly(vinyl alcohol) (PVA) is a synthetic, biocompatible polymer that has been widely studied for use in bioengineered tissue scaffolds due to its relatively high strength, creep resistance, water retention, and porous structure. However, PVA hydrogels traditionally exhibit low percent elongation and energy dissipation. PVA material and mechanical properties can be fine-tuned by controlling the physical, non-covalent crosslinks during hydrogel formation through various techniques; PVA scaffolds were modified with gelatin, a natural collagen derivative also capable of forming reversible hydrogen bonds. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.002DOI Listing
January 2019
1 Read

Design and material evaluation for a novel lumbar disc replacement implanted via unilateral transforaminal approach.

J Mech Behav Biomed Mater 2019 Mar 20;91:383-390. Epub 2018 Dec 20.

Department of Mechanical Engineering, School of Engineering, University of Birmingham, UK.

The degeneration of the intervertebral disc is one of the principal causes of low back pain. Total disc replacement is a surgical treatment that aims to replace the degenerated disc with a dynamic implant to restore spine biomechanics. This paper proposes the first design of an elastomeric lumbar disc replacement that is implanted as a pair of devices via unilateral transforaminal surgical approach. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.011DOI Listing
March 2019
1 Read

Numerical modeling of bone as a multiscale poroelastic material by the homogenization technique.

J Mech Behav Biomed Mater 2019 Mar 15;91:373-382. Epub 2018 Dec 15.

DIMA, University of Rome, La Sapienza, Rome, Italy.

Bone is a complex material showing a hierarchical and porous structure but also a natural ability to remodel thanks to cells sensitive to fluid flows. Based on these characteristics, a multiscale numerical model has been developed in order to represent the bone response under mechanical solicitation. It relies on the homogenization technique, simulating bone as a homogeneous structure having a porous microstructure saturated with bone fluid. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.015DOI Listing

Biodegradable waterborne polyurethane grafted with gelatin hydrolysate via solvent-free copolymerization for potential porous scaffold material.

J Mech Behav Biomed Mater 2019 Jan 9;92:79-89. Epub 2019 Jan 9.

School of Light Industry and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China. Electronic address:

One potential porous scaffold material based on polyester waterborne polyurethane (PEUR) grafted with modified gelatin hydrolysate (GH) has been investigated in this research. First, the GH was modified with a silane coupling agent (KH550), and then the modified GH was mixed with pre-polymer emulsion of PEUR to obtain the PEUR grafted GH emulsion (PEUR-g-GH). The synthesized PEUR-g-GH emulsions were characterized by stability analysis and viscosity test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161183140
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http://dx.doi.org/10.1016/j.jmbbm.2019.01.005DOI Listing
January 2019
3 Reads

Quantitative/qualitative analysis of adhesive-dentin interface in the presence of 10-methacryloyloxydecyl dihydrogen phosphate.

J Mech Behav Biomed Mater 2018 Dec 30;92:71-78. Epub 2018 Dec 30.

Department of Conservative Dentistry, Division of Biomaterials and Engineering, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Dental adhesive provides effective retention of filling materials via adhesive-dentin hybridization. The use of co-monomers, such as 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP), is thought to be crucial for hybridization owing to their ionic-binding to calcium and co-polymerization in the polymerizable adhesives. Optimal hybridization partly depends on the mechanical properties of polymerized adhesives, which are likely to be proportional to the degree of conversion ratio. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.038DOI Listing
December 2018

Response of pre-crystallized CAD/CAM zirconia-reinforced lithium silicate glass ceramic to cyclic nanoindentation.

J Mech Behav Biomed Mater 2019 Jan 10;92:58-70. Epub 2019 Jan 10.

School of Mechanical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address:

This paper reports on a cyclic nanoindentation approach of a pre-crystallized zirconia-reinforced lithium silicate glass ceramic (ZLS) to understand its material behavior associated with its machinability in dental CAD/CAM diamond abrasive milling. The material response to the cyclic nanoindentation using a Berkovich diamond tip was quantitatively determined in terms of the indentation contact hardness, elastic modulus, elasticity and plasticity for each loading cycle at peak loads of 2.5-10 mN. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.004DOI Listing
January 2019

Crack initiation from a clinically relevant notch in a highly-crosslinked UHMWPE subjected to static and cyclic loading.

J Mech Behav Biomed Mater 2019 Mar 28;91:366-372. Epub 2018 Dec 28.

Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, OH 44106, United States. Electronic address:

Crosslinked Ultra High Molecular Weight Polyethylene (UHMWPE), which is used as a bearing material in total joint replacement components, is subjected to static and cyclic loads in vivo. Resistance to crack initiation from a notch as a function of static and cyclic loads is not well understood for crosslinked UHMWPE. This study estimated the resistance of crosslinked UHMWPE (crosslinked with 100 kGy gamma radiation and remelted to extinguish free radicals) to crack initiation for a clinically relevant notch under both static and cyclic loading conditions. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.032DOI Listing

Processing and properties of Na-doped porous calcium polyphosphates - Mechanical properties and in vitro degradation characteristics.

J Mech Behav Biomed Mater 2019 Mar 21;91:355-365. Epub 2018 Dec 21.

Institute of Biomaterials & Biomedical Engineering, University of Toronto, Canada; Laboratory of Medicine & Pathobiology, Mount Sinai Hospital, Toronto, Canada.

Porous calcium polyphosphate (CPP) is being investigated for use as a biodegradable bone substitute and for repair of osteochondral defects. The necessary requirements for these applications, particularly in load-bearing sites, include sufficient strength to withstand functional forces prior to bone ingrowth and substitution of the initial porous CPP template with new bone and cartilage (for osteochondral implants) in a timely and efficacious manner. The present study explored the effects of Na doping and processing to form porous structures of both higher strength and faster degradation than previously reported for 'pure' (non-doped) CPP structures of similar geometry. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.025DOI Listing

Myoglobin and troponin concentrations are increased in early stage deep tissue injury.

J Mech Behav Biomed Mater 2018 Dec 21;92:50-57. Epub 2018 Dec 21.

Regenerative Engineering & Materials, Department of Biomedical Engineering, Eindhoven University of Technology, the Netherlands.

Pressure-induced deep tissue injury is a form of pressure ulcer which is difficult to detect and diagnose at an early stage, before the wound has severely progressed and becomes visible at the skin surface. At the present time, no such detection technique is available. To test the hypothesis that muscle damage biomarkers can be indicative of the development of deep tissue injury after sustained mechanical loading, an indentation test was performed for 2 h on the tibialis anterior muscle of rats. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.026DOI Listing
December 2018

Experimental and numerical study on tensile failure behavior of bionic suture joints.

J Mech Behav Biomed Mater 2019 Jan 4;92:40-49. Epub 2019 Jan 4.

School of Aeronautics, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China; Shaanxi Key Laboratory of Impact Dynamics and its Engineering Applications, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China. Electronic address:

Sutured architectures with weak interfaces, such as bone or nacres, have a great potential in engineering for the design of joints. In this investigation, which is inspired by the subtle designs that occur in nature, the geometrically structured interfaces of living and fossil organisms are converted into a model for a suture joint. Through a combined numerical and experimental study using three-dimensional (3D) printed suture joint specimens, the tensile failure behavior of first-order bionic suture joints is systematically studied. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.01.001DOI Listing
January 2019

Research of the role of microstructure in the wear mechanism of canine and bovine enamel.

J Mech Behav Biomed Mater 2018 Dec 28;92:33-39. Epub 2018 Dec 28.

Tribology Research Institute, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China.

The relationship between the microstructure and tribological behavior of mammalian tooth enamel has not been fully understood. In this paper, the microstructure, mechanical properties, and tribological behavior of canine (carnivore) and bovine (herbivore) enamel are studied using scanning electronic microscopy and nano-indentation/scratch technique, aiming to reveal the contribution of enamel microstructure to its mechanical and tribological properties. Canine enamel has a microstructure of hard keyhole-like rods embedded in soft inter-rod enamel, and its surface exhibits high resistance against both micro-crack initiation and crack-induced delamination during friction and wear process. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.036DOI Listing
December 2018

"Peroperative estimation of bone quality and primary dental implant stability".

J Mech Behav Biomed Mater 2018 Dec 28;92:24-32. Epub 2018 Dec 28.

Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014 Bern, Switzerland; Institute for Mechanical, Process and Energy Engineering, Heriot-Watt University, UK EH14 4AS, Edinburgh, United Kingdom.

Objectives: Dental implants are widely used to restore function and appearance. It may be essential to choose the appropriate drilling protocol and implant design in order to optimise primary stability. This could be achieved based on an assessment of the implantation site with respect to bone quality and objective biomechanical descriptors such as stiffness and strength of the bone-implant system. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.035DOI Listing
December 2018

Anisotropic cellular forces support mechanical integrity of the Stratum Corneum barrier.

J Mech Behav Biomed Mater 2018 Dec 27;92:11-23. Epub 2018 Dec 27.

L'Oréal Research and Innovation, Aulnay-sous-Bois, France. Electronic address:

The protective function of biological surfaces that are exposed to the exterior of living organisms is the result of a complex arrangement and interaction of cellular components. This is the case for the most external cornified layer of skin, the stratum corneum (SC). This layer is made of corneocytes, the elementary 'flat bricks' that are held together through adhesive junctions. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.027DOI Listing
December 2018
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Integrating structural heterogeneity, fiber orientation, and recruitment in multiscale ECM mechanics.

J Mech Behav Biomed Mater 2018 Dec 21;92:1-10. Epub 2018 Dec 21.

Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. Electronic address:

Extracellular matrix (ECM) plays critical roles in establishing tissue structure-function relationships and controlling cell fate. However, the mechanisms by which ECM mechanics influence cell and tissue behavior remain to be elucidated since the events associated with this process span length scales from the tissue to molecular level. Entirely new methods are needed in order to better understand the multiscale mechanics of ECM. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.023DOI Listing
December 2018

Mechanical properties of Bio-Ferrography isolated cancerous cells studied by atomic force microscopy.

J Mech Behav Biomed Mater 2019 Mar 31;91:345-354. Epub 2018 Dec 31.

Biomaterials and Corrosion Laboratory, Department of Materials Science and Engineering, Tel-Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel. Electronic address:

Detecting the presence of circulating tumor cells (CTCs) in peripheral blood can be useful for monitoring treatment in patients, metastasis prognosis, and even early detection. The epidermal growth factor receptor (EGFR) is overexpressed in carcinoma, e.g. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.039DOI Listing

Dry sliding wear behaviour of β-type Ti-Nb and Ti-Mo surfaces designed by diffusion treatments for biomedical applications.

J Mech Behav Biomed Mater 2019 Mar 24;91:335-344. Epub 2018 Dec 24.

University Carlos III of Madrid, Department of Materials Science and Engineering, IAAB, Avda. Universidad, 30, 28911 Leganés, Spain; ALvaro Alonso Barba Technological Institute of Chemistry And Materials, University Carlos III of Madrid, Spain. Electronic address:

The dry sliding wear behaviour of different Ti-Nb and Ti-Mo surfaces was investigated in order to evaluate the role of Nb and Mo β-stabilizing elements in titanium wear resistance to consider them for biomedical applications. Dry sliding wear tests were performed under unlubricated conditions using a ball-on-plate tribometer (UMT) with reciprocating lineal movement of 1 Hz frequency at different loads (2 and 5 N) and against two counterface materials (alumina and stainless steel) to assess the effect of these parameters on wear. The results indicated an improvement in wear resistance for all the modified Ti surfaces. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.029DOI Listing

Sequential usage of diamond bur for CAD/CAM milling: Effect on the roughness, topography and fatigue strength of lithium disilicate glass ceramic.

J Mech Behav Biomed Mater 2019 Mar 27;91:326-334. Epub 2018 Dec 27.

MSciD and PhD Post-Graduate Program in Restorative Dentistry (Prosthodontics Unit), São Paulo State University (Unesp), Institute of Science and Technology, São José dos Campos, São Paulo State, Brazil. Electronic address:

The aim of this study was to evaluate the effect of sequential usage (milling order) of CAD/CAM diamond burs on the surface roughness, topography and fatigue performance of a lithium disilicate glass-ceramic. Seventy-two (72) ceramic discs (Ø= 13.5 mm; thickness= 1. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.037DOI Listing

Static and time-dependent mechanical response of organic matrix of bone.

J Mech Behav Biomed Mater 2019 Mar 24;91:315-325. Epub 2018 Dec 24.

Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.

Bone derives its mechanical strength from the complex arrangement of collagen fibrils (type-I primarily) reinforced with hydroxy-apatite (HAp) mineral crystals in extra- and intra-fibrillar compartments. This study demonstrates a novel approach to obtain organic matrix of bone through its demineralization as well as mechanically characterize it at small length scales using static and dynamic indentation techniques. Sample surface preparation protocol used in the present work maintained the surface integrity of demineralized bone samples which resulted sample surface of roughness (RMS) magnitude of approximately 14 nm (averaged over 1 × 1 μm area duly verified by atomic force microscope (AFM)). Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.031DOI Listing
March 2019
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Composite vs. ionomer vs. mixed restoration of wedge-shaped dental cervical lesions: Marginal quality relative to eccentric occlusal loading.

J Mech Behav Biomed Mater 2019 Mar 25;91:309-314. Epub 2018 Dec 25.

Department of Operative Dentistry, University of São Paulo, School of Dentistry, Avenida Professor Lineu Prestes, 2227, São Paulo, SP 05508-000, Brazil. Electronic address:

Dental cervical restorations may be impacted by resultants of occlusal loads that may have already contributed to the development of the lesion and should rely on materials' favorable properties to bear the stresses. The marginal quality of cervical restorations made with materials of different moduli of elasticity in essence, isolated, or in combination, was evaluated relative to eccentric occlusal loading. Cervical wedge-shaped cavities, prepared in extracted premolars, were restored with a composite resin (CR), a restorative ionomer (GIC), or the composite in combination with a lining ionomer (Mixed restoration: M). Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.034DOI Listing

Interaction of ACP and MDP and its effect on dentin bonding performance.

J Mech Behav Biomed Mater 2019 Mar 18;91:301-308. Epub 2018 Dec 18.

Department of Prosthodontics, Hospital of Stomatology Affiliated to Zhejiang University School of Medicine, Yan'an Road 395,Hangzhou 310006, Zhejiang, China; Key Laboratory for Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, Zhejiang, China. Electronic address:

Objectives: The study investigated the solid reactants of amorphous calcium phosphate (ACP) nanoparticles with 10-methacryloyloxydecyl dihydrogen phosphate (MDP) in ethanol-aqueous solution, and the effect of ACP-MDP suspension as a novel primer on dentin micro-tesnisl bond strengths (MTBS) prior to application of self-etch adhesives.

Materials And Methods: The ACP nanoparticles were synthesized. The solid reactants of ACP nanoparticles with MDP ethanol-aqueous solution were analyzed by TEM, SEM, XRD and AFM. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.12.017DOI Listing
March 2019
8 Reads

Full-field analysis of epicardial strain in an in vitro porcine heart platform.

J Mech Behav Biomed Mater 2019 Mar 30;91:294-300. Epub 2018 Nov 30.

Mathematical Modelling in Medicine Group, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, UK. Electronic address:

The quantitative assessment of cardiac strain is increasingly performed to provide valuable insights on heart function. Currently, the most frequently used technique in the clinic is ultrasound-based speckle tracking echocardiography (STE). However, verification and validation of this modality are still under investigation and further reference measurements are required to support this activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161183130
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http://dx.doi.org/10.1016/j.jmbbm.2018.11.025DOI Listing
March 2019
1 Read