1,558 results match your criteria Journal of the International AIDS Society [Journal]


HIV care cascade and sustainable wellbeing of people living with HIV in context.

J Int AIDS Soc 2019 Feb;22(2):e25259

Department of Social Policy, London School of Economics and Politics (LSE), London, United Kingdom.

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http://dx.doi.org/10.1002/jia2.25259DOI Listing
February 2019

Persistence on HIV preexposure prophylaxis medication over a 2-year period among a national sample of 7148 PrEP users, United States, 2015 to 2017.

J Int AIDS Soc 2019 Feb;22(2):e25252

Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Introduction: Persistence on preexposure prophylaxis for HIV prevention (PrEP) medication has rarely been reported for periods greater than one year, or in real-world settings. This study used pharmacy fill records for PrEP users from a national chain pharmacy to describe persistence on PrEP medication over a two-year period, and to explore correlates with PrEP medication persistence in a real-world setting.

Methods: We analysed de-identified pharmacy fill records of 7148 eligible individuals who initiated PrEP in 2015 at a national chain pharmacy. Read More

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http://dx.doi.org/10.1002/jia2.25252DOI Listing
February 2019
1 Read

Pre-exposure prophylaxis initiation and adherence among Black men who have sex with men (MSM) in three US cities: results from the HPTN 073 study.

J Int AIDS Soc 2019 Feb;22(2):e25223

Department of Human Development, State University of New York at BinghamtonBinghamton, NY, USA.

Introduction: Randomized clinical trials have demonstrated the efficacy of antiretroviral pre-exposure prophylaxis (PrEP) in preventing HIV acquisition among men who have sex with men (MSM). However, limited research has examined initiation and adherence to PrEP among Black MSM (BMSM) in the United States (US) who are disproportionately represented among newly HIV infected and late to care individuals. This research reports on the HIV Prevention Trials Network 073 (HPTN 073) study aimed to examine PrEP initiation, utilization and adherence among Black MSM utilizing the theoretically principled, culturally informed and client-centered care coordination (C4) model. Read More

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http://dx.doi.org/10.1002/jia2.25223DOI Listing
February 2019
5.090 Impact Factor

Patterns and clinical consequences of discontinuing HIV preexposure prophylaxis during primary care.

J Int AIDS Soc 2019 Feb;22(2):e25250

Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Introduction: Discontinuations of HIV preexposure prophylaxis (PrEP) by at-risk individuals could decrease the effectiveness of PrEP. Our objective was to characterize patterns of, reasons for, and clinical outcomes associated with PrEP discontinuations in primary care.

Methods: We conducted medical chart reviews for patients prescribed PrEP during 2011 to 2014 at a Boston community health centre specializing in healthcare for sexual and gender minorities. Read More

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http://doi.wiley.com/10.1002/jia2.25250
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http://dx.doi.org/10.1002/jia2.25250DOI Listing
February 2019
2 Reads

Longitudinal changes in HIV DNA in HIV controllers: what do they mean?

J Int AIDS Soc 2019 Feb;22(2):e25254

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/jia2.25254DOI Listing
February 2019

ART adherence and viral suppression are high among most non-pregnant individuals with early-stage, asymptomatic HIV infection: an observational study from Uganda and South Africa.

J Int AIDS Soc 2019 Feb;22(2):e25232

Oregon Health & Science University-Portland State University School of Public Health, Portland, OR, USA.

Introduction: The success of universal antiretroviral therapy (ART) access and aspirations for an AIDS-free generation depend on high adherence in individuals initiating ART during early-stage HIV infection; however, adherence may be difficult in the absence of illness and associated support.

Methods: From March 2015 to October 2017, we prospectively observed three groups initiating ART in routine care in Uganda and South Africa: men and non-pregnant women with early-stage HIV infection (CD4 > 350 cells/μL), pregnant women with early-stage HIV infection and men and non-pregnant women with late-stage HIV infection (CD4 < 200 cells/μL). Socio-behavioural questionnaires were administered and viral loads were performed at 0, 6 and 12 months. Read More

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http://dx.doi.org/10.1002/jia2.25232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371013PMC
February 2019

A latent class approach to identify multi-risk profiles associated with phylogenetic clustering of recent hepatitis C virus infection in Australia and New Zealand from 2004 to 2015.

J Int AIDS Soc 2019 Feb;22(2):e25222

Kirby Institute, UNSW, Sydney, NSW, Australia.

Introduction: Over the last two decades, the incidence of hepatitis C virus (HCV) co-infection among men who have sex with men (MSM) living with HIV began increasing in post-industrialized countries. Little is known about transmission of acute or recent HCV, in particular among MSM living with HIV co-infection, which creates uncertainty about potential for reinfection after HCV treatment. Using phylogenetic methods, clinical, epidemiological and molecular data can be combined to better understand transmission patterns. Read More

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http://dx.doi.org/10.1002/jia2.25222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371014PMC
February 2019
1 Read

Retention on antiretroviral therapy during Universal Test and Treat implementation in Zomba district, Malawi: a retrospective cohort study.

J Int AIDS Soc 2019 Feb;22(2):e25239

Dignitas International, Zomba, Malawi.

Introduction: Since June 2016, the national HIV programme in Malawi has adopted Universal Test and Treat (UTT) guidelines requiring that all persons who test HIV positive will be referred to start antiretroviral therapy (ART). Although there is strong evidence from clinical trials that early initiation of ART leads to reduced morbidity and mortality, the impact of UTT on retention on ART in real-life programmatic settings in Africa is not yet known.

Methods: We conducted a retrospective cohort study in Zomba district, Malawi to compare ART outcomes of patients who initiated ART under 2016 UTT guidelines and those who started ART prior to rollout of UTT (pre-UTT). Read More

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http://dx.doi.org/10.1002/jia2.25239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367572PMC
February 2019

Current challenges and recent advances in the search for a cure for HIV.

Authors:
R Brad Jones

J Int AIDS Soc 2019 Feb;22(2):e25248

Infectious Diseases Division, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/jia2.25248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367571PMC
February 2019

PrEP uptake preferences among men who have sex with men in China: results from a National Internet Survey.

J Int AIDS Soc 2019 Feb;22(2):e25242

Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Introduction: HIV incidence among men who have sex with men (MSM) is high in China. Pre-exposure prophylaxis (PrEP) is a promising mean to prevent HIV transmission but it is not widely available in China. We conducted a large Internet-based online survey to assess the willingness of Chinese MSM to take PrEP and associated factors to their uptake preferences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jia2.25242
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http://dx.doi.org/10.1002/jia2.25242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364490PMC
February 2019
2 Reads

"Is it making any difference?" A qualitative study examining the treatment-taking experiences of asymptomatic people living with HIV in the context of Treat-all in Eswatini.

J Int AIDS Soc 2019 Jan;22(1):e25220

Médecins Sans Frontières, Nhlangano, Eswatini.

Introduction: Treat-all is being implemented in several African settings, in accordance with 2015 World Health Organisation guidelines. The factors known to undermine adherence to antiretroviral therapy (ART) may change in the context of Treat-all, where people living with HIV (PLHIV) increasingly initiate ART at earlier, asymptomatic stages of disease, soon after diagnosis. This paper aimed to examine the asymptomatic PLHIV's experiences engaging with early ART initiation under the Treat-all policy, including how they navigate treatment-taking over the longer term. Read More

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http://dx.doi.org/10.1002/jia2.25220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351702PMC
January 2019
5.090 Impact Factor

Trends and predictors of non-communicable disease multimorbidity among adults living with HIV and receiving antiretroviral therapy in Brazil.

J Int AIDS Soc 2019 Jan;22(1):e25233

National Institute of Infectology - Evandro Chagas, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Introduction: People living with HIV (PLHIV) on antiretroviral therapy (ART) experience high rates of non-communicable diseases (NCDs). These co-morbidities often accumulate and older adults may suffer from multimorbidity. Multimorbidity has been associated with loss of quality of life, polypharmacy, and increased risk of frailty and mortality. Read More

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http://dx.doi.org/10.1002/jia2.25233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351749PMC
January 2019
2 Reads

Diabetes mellitus burden among people living with HIV from the Asia-Pacific region.

J Int AIDS Soc 2019 Jan;22(1):e25236

HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Introduction: Comorbidities including diabetes mellitus (DM) among people living with HIV (PLHIV) are of increasing clinical concerns in combination antiretroviral therapy (cART) era. We aimed to determine the incidence and risk factors of new-onset DM among PLHIV in Asian settings.

Methods: PLHIV from a regional observational cohort without DM prior to antiretroviral therapy (ART) initiation were included in the analysis. Read More

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http://dx.doi.org/10.1002/jia2.25236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351701PMC
January 2019
1 Read

The HIV care continuum among resident and non-resident populations found in venues in East Africa cross-border areas.

J Int AIDS Soc 2019 Jan;22(1):e25226

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Introduction: HIV care and treatment in cross-border areas in East Africa face challenges perhaps not seen to the same extent in other geographic areas, particularly for mobile and migrant populations. Here, we estimate the proportion of people with HIV found in these cross-border areas in each stage of the HIV care and treatment cascade, including the proportion who knows their status, the proportion on treatment and the proportion virally suppressed.

Methods: Participants (n = 11,410) working or socializing in public places in selected East Africa cross border areas were recruited between June 2016 and February 2017 using the Priorities for Local AIDS Control Efforts method and administered a behavioural survey and rapid HIV test. Read More

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http://dx.doi.org/10.1002/jia2.25226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344908PMC
January 2019
4 Reads

Questionable assumptions mar modelling of Kenya home-based testing campaigns.

J Int AIDS Soc 2019 Jan;22(1):e25230

South African Centre for Epidemiological Modelling and Analysis, Stellenbosch, South Africa.

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http://dx.doi.org/10.1002/jia2.25230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341973PMC
January 2019

Effectiveness of dolutegravir-based regimens as either first-line or switch antiretroviral therapy: data from the Icona cohort.

J Int AIDS Soc 2019 Jan;22(1):e25227

Clinic of Infectious and Tropical Diseases, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.

Introduction: Concerns about dolutegravir (DTG) tolerability in the real-life setting have recently arisen. We aimed to estimate the risk of treatment discontinuation and virological failure of DTG-based regimens from a large cohort of HIV-infected individuals.

Methods: We performed a multicentre, observational study including all antiretroviral therapy (ART)-naïve and virologically suppressed treatment-experienced (TE) patients from the Icona (Italian Cohort Naïve Antiretrovirals) cohort who started, for the first time, a DTG-based regimen from January 2015 to December 2017. Read More

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http://dx.doi.org/10.1002/jia2.25227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340053PMC
January 2019
1 Read

Research priorities to inform "Treat All" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the International epidemiology Databases to Evaluate AIDS (IeDEA).

J Int AIDS Soc 2019 Jan;22(1):e25218

Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA.

Introduction: "Treat All" - the treatment of all people with HIV, irrespective of disease stage or CD4 cell count - represents a paradigm shift in HIV care that has the potential to end AIDS as a public health threat. With accelerating implementation of Treat All in sub-Saharan Africa (SSA), there is a need for a focused agenda and research to identify and inform strategies for promoting timely uptake of HIV treatment, retention in care, and sustained viral suppression and addressing bottlenecks impeding implementation.

Methods: The Delphi approach was used to develop consensus around research priorities for Treat All implementation in SSA. Read More

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http://dx.doi.org/10.1002/jia2.25218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338103PMC
January 2019
3 Reads
5.090 Impact Factor

Beyond HIV prevention: everyday life priorities and demand for PrEP among Ugandan HIV serodiscordant couples.

J Int AIDS Soc 2019 Jan;22(1):e25225

Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.

Introduction: Pre-exposure prophylaxis (PrEP) to prevent HIV infection is being rolled out in Africa. The uptake of PrEP to date has varied across populations and locations. We seek to understand the drivers of demand for PrEP through analysis of qualitative data collected in conjunction with a PrEP demonstration project involving East African HIV serodiscordant couples. Read More

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http://dx.doi.org/10.1002/jia2.25225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338102PMC
January 2019
1 Read
5.090 Impact Factor

"In the United States, we say, 'No breastfeeding,' but that is no longer realistic": provider perspectives towards infant feeding among women living with HIV in the United States.

J Int AIDS Soc 2019 Jan;22(1):e25224

Department of Gynecology/Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction: Currently, the United States (U.S.) recommends that infants born to women living with HIV (WLHIV) be fed formula, whereas many low-resource settings follow the World Health Organization's recommendation to exclusively breastfeed with ongoing antiretroviral therapy. Read More

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http://dx.doi.org/10.1002/jia2.25224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338297PMC
January 2019
2 Reads

Attrition of HIV-exposed infants from early infant diagnosis services in low- and middle-income countries: a systematic review and meta-analysis.

J Int AIDS Soc 2018 Nov;21(11):e25209

Yale School of Public Health, Yale University, New Haven, CT, USA.

Introduction: Identification and retention of HIV-exposed infants in early infant diagnosis (EID) services helps to ensure optimal health outcomes. This systematic review and meta-analysis examines the magnitude of attrition from EID services in low- and middle-income countries (LMICs).

Methods: We performed a comprehensive database search through April 2016. Read More

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http://doi.wiley.com/10.1002/jia2.25209
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http://dx.doi.org/10.1002/jia2.25209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287094PMC
November 2018
4 Reads

Dynamics in HIV-DNA levels over time in HIV controllers.

J Int AIDS Soc 2019 Jan;22(1):e25221

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Introduction: HIV controllers (HIC) maintain viraemia at low levels without antiretroviral treatment and have small HIV reservoirs. Nevertheless, they are heterogeneous regarding their risk of infection progression. The study of reservoirs can help elucidate this control. Read More

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http://doi.wiley.com/10.1002/jia2.25221
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http://dx.doi.org/10.1002/jia2.25221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327944PMC
January 2019
8 Reads

Trends in mortality among ART-treated HIV-infected adults in the Asia-Pacific region between 1999 and 2017: results from the TREAT Asia HIV Observational Database (TAHOD) and Australian HIV Observational Database (AHOD) of IeDEA Asia-Pacific.

J Int AIDS Soc 2019 Jan;22(1):e25219

AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

Introduction: AIDS-related deaths in people living with HIV/AIDS have been decreasing in number since the introduction of combination antiretroviral treatment (cART). However, data on recent causes of death in the Asia-Pacific region are limited. Hence, we analysed and compared AIDS-related and non-AIDS-related mortality in high- and low-income settings in the region. Read More

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http://doi.wiley.com/10.1002/jia2.25219
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http://dx.doi.org/10.1002/jia2.25219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322485PMC
January 2019
1 Read

Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation.

J Int AIDS Soc 2018 Nov;21(11):e25200

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Introduction: The CD4 cell count and percent at initiation of combination antiretroviral therapy (cART) are measures of advanced HIV disease and thus are important indicators of programme performance for children living with HIV. In particular, World Health Organization (WHO) 2017 guidelines on advanced HIV disease noted that >80% of children aged <5 years started cART with WHO Stage 3 or 4 disease or severe immune suppression. We compared temporal trends in CD4 measures at cART start in children from low-, middle- and high-income countries, and examined the effect of WHO treatment initiation guidelines on reducing the proportion of children initiating cART with advanced disease. Read More

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http://dx.doi.org/10.1002/jia2.25200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275813PMC
November 2018
5 Reads

Molecular epidemiology of a primarily MSM acute HIV-1 cohort in Bangkok, Thailand and connections within networks of transmission in Asia.

J Int AIDS Soc 2018 Nov;21(11):e25204

United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Introduction: Thailand plays a substantial role in global HIV-1 transmission of CRF01_AE. Worldwide, men who have sex with men (MSM) are at elevated risk for HIV-1 infection. Hence, understanding HIV-1 diversity in a primarily Thai MSM cohort with acute infection, and its connections to the broader HIV-1 transmission network in Asia is crucial for research and development of HIV-1 vaccines, treatment and cure. Read More

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http://dx.doi.org/10.1002/jia2.25204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282942PMC
November 2018
3 Reads
5.090 Impact Factor

Social franchising of community-based HIV testing and linkage to HIV care and treatment services: an evaluation of a pilot study in Tshwane, South Africa.

J Int AIDS Soc 2018 Dec;21(12):e25216

Foundation for Professional Development, Pretoria, South Africa.

Introduction: Although HIV testing services (HTS) have been successfully task-shifted to lay counsellors, no model has tested the franchising of HTS to lay counsellors as independent small-scale business owners. This paper evaluates the effectiveness of a social franchisee (SF) HTS-managed pilot project compared to the Foundation for Professional Development (FPD) employee-managed HTS programme in testing and linking clients to care.

Methods: Unemployed, formally employed or own business individuals were engaged as franchisees, trained and supported to deliver HTS services under a common brand in high HIV-prevalent communities in Tshwane district between 2016 and 2017. Read More

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http://dx.doi.org/10.1002/jia2.25216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300754PMC
December 2018

High prevalence of binge drinking among people living with HIV in four African countries.

J Int AIDS Soc 2018 Dec;21(12):e25202

Service de maladies infectieuses et tropicales, CRCF, CHU de Fann, Dakar, Sénégal.

Introduction: Excessive alcohol consumption leads to unfavourable outcomes in people living with HIV (PLHIV), including reduced adherence to antiretroviral therapy (ART) and engagement into care. However, there is limited information on alcohol consumption patterns among PLHIV in sub-Saharan Africa.

Methods: Using a cross-sectional approach, the Alcohol Use Disorders Identification Test (AUDIT-C) was administered to PLHIV attending HIV clinics in Côte d'Ivoire, Togo, Senegal and Zambia (2013 to 2015). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jia2.25202
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http://dx.doi.org/10.1002/jia2.25202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294116PMC
December 2018
14 Reads

Persons living with HIV with advanced HIV disease: need for novel care models.

J Int AIDS Soc 2018 Dec;21(12):e25210

ICAP-Columbia University, Mailman School of Public Health, Columbia University, New York, NY, USA.

Introduction: Despite increasing focus on test and treat strategies for people living with HIV (PLHIV), many continue to enrol late in care and initiate antiretroviral therapy (ART) when they have advanced HIV disease.

Methods: We analyzed PLHIV ≥15 years of age starting ART in Ethiopia, Kenya, Mozambique and Tanzania from 2005 to 2015 based on CD4+ groups at ART initiation (≥200, 100 to 199, 50 to 99 and <50 cells/mm ) to examine attrition (loss to follow-up (LTF) and death) using Kaplan-Meier estimators and Cox proportional hazards models. LTF was defined as no clinic visit >6 months; deaths were ascertained from medical records. Read More

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http://dx.doi.org/10.1002/jia2.25210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293147PMC
December 2018

Assessing the adoption of lopinavir/ritonavir oral pellets for HIV-positive children in Zimbabwe.

J Int AIDS Soc 2018 Dec;21(12):e25214

AIDS and TB Unit, The Ministry of Health and Child Care, Harare, Zimbabwe.

Introduction: Heat-stable lopinavir/ritonavir (LPV/r) oral pellets were developed to overcome challenges with administration and storage experienced with previously available tablet and syrup forms of LPV/r prescribed to paediatric HIV patients. We report on the adoption of LPV/r pellets for infants living with HIV in the public sector antiretroviral therapy (ART) programme in Zimbabwe.

Methods: Infants aged three months to three years who had been prescribed a LPV/r-based regimen (including ART-naïve patients) in fourteen facilities across the country were eligible to receive the pellets. Read More

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http://dx.doi.org/10.1002/jia2.25214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293134PMC
December 2018
2 Reads
5.090 Impact Factor

Mortality and losses to follow-up among adolescents living with HIV in the IeDEA global cohort collaboration.

J Int AIDS Soc 2018 Dec;21(12):e25215

TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand.

Introduction: We assessed mortality and losses to follow-up (LTFU) during adolescence in routine care settings in the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.

Methods: Cohorts in the Asia-Pacific, the Caribbean, Central, and South America, and sub-Saharan Africa (Central, East, Southern, West) contributed data, and included adolescents living with HIV (ALHIV) enrolled from January 2003 and aged 10 to 19 years (period of adolescence) while under care up to database closure (June 2016). Follow-up started at age 10 years or the first clinic visit, whichever was later. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jia2.25215
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http://dx.doi.org/10.1002/jia2.25215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291755PMC
December 2018
11 Reads
5.090 Impact Factor

Incorporating digital anorectal examinations for anal cancer screening into routine HIV care for men who have sex with men living with HIV: a prospective cohort study.

J Int AIDS Soc 2018 Dec;21(12):e25192

Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Introduction: Men who have sex with men (MSM) living with HIV have a high risk of anal cancer, which is often detected at late stages, when morbidity and mortality are high. The objective of this study was to describe the feasibility and challenges to incorporating regular digital anorectal examination (DARE) into routine HIV care for MSM living with HIV, from the perspective of patients, physicians and the health service.

Methods: In 2014, we recruited 327 MSM living with HIV, aged 35 and above from one major sexual health centre (n = 187), two high HIV caseload general practices (n = 118) and one tertiary hospital (n = 22) in Melbourne, Australia. Read More

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http://dx.doi.org/10.1002/jia2.25192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280647PMC
December 2018
1 Read
5.090 Impact Factor

Impact of a borderless sample transport network for scaling up viral load monitoring: results of a geospatial optimization model for Zambia.

J Int AIDS Soc 2018 Dec;21(12):e25206

Department of Global Health, School of Public Health, Boston University, Boston, MA, USA.

Introduction: The World Health Organization recommends viral load (VL) monitoring at six and twelve months and then annually after initiating antiretroviral treatment for HIV. In many African countries, expansion of VL testing has been slow due to a lack of efficient blood sample transportation networks (STN). To assist Zambia in scaling up testing capacity, we modelled an optimal STN to minimize the cost of a national VL STN. Read More

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http://dx.doi.org/10.1002/jia2.25206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280013PMC
December 2018
2 Reads

The importance of serostatus awareness in arresting the spread of HIV.

J Int AIDS Soc 2018 Nov;21(11):e25217

Journal of the International AIDS Society, Geneva, Switzerland.

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http://dx.doi.org/10.1002/jia2.25217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265236PMC
November 2018
12 Reads

Retention in clinic versus retention in care during the first year of HIV care in Nairobi, Kenya: a prospective cohort study.

J Int AIDS Soc 2018 Nov;21(11):e25196

Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Introduction: When measuring the success of HIV programmes to retain patients in care, few studies distinguish between retention in clinic (individual returns to the same clinic) and retention in care (individual is active in care at initial site or elsewhere). The objectives of this study were to quantify retention in clinic versus retention in care and determine risk factors associated with attrition from care in low-income settings in Nairobi, Kenya.

Methods: Between April 2013 and June 2015, adults testing positive for HIV were recruited at two comprehensive care clinics in informal urban settlements. Read More

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http://dx.doi.org/10.1002/jia2.25196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263088PMC
November 2018
5 Reads

The importance of local epidemic conditions in monitoring progress towards HIV epidemic control in Kenya: a modelling study.

J Int AIDS Soc 2018 Nov;21(11):e25203

Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

Introduction: Setting and monitoring progress towards targets for HIV control is critical in ensuring responsive programmes. Here, we explore how to apply targets for reduction in HIV incidence to local settings and which indicators give the strongest signal of a change in incidence in the population and are therefore most important to monitor.

Methods: We use location-specific HIV transmission models, tailored to the epidemics in the counties and major cities in Kenya, to project a wide range of plausible future epidemic trajectories through varying behaviours, treatment coverage and prevention interventions. Read More

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http://dx.doi.org/10.1002/jia2.25203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260921PMC
November 2018

Neonatal and infant diagnostic HIV-PCR uptake and associations during three sequential policy periods in Cape Town, South Africa: a longitudinal analysis.

J Int AIDS Soc 2018 Nov;21(11):e25212

Centre for Infectious Disease Epidemiology & Research, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

Introduction: To strengthen the early infant diagnosis (EID) programmes and timeously identify and treat HIV-infected infants, birth HIV-PCR for some/all infants has been recommended in the Western Cape, South Africa since 2014. Operational data on the implementation of such programmes in low- and middle-income countries are limited.

Methods: Utilizing the electronic records platform at primary care facilities, we developed an electronic register which consolidated obstetric and HIV-related data, allowing us to track a cohort of HIV-infected/exposed mother/infant dyads longitudinally from antenatal care through delivery to infant HIV-PCR. Read More

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http://dx.doi.org/10.1002/jia2.25212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256843PMC
November 2018
12 Reads

Clinical exigencies, psychosocial realities: negotiating HIV pre-exposure prophylaxis beyond the cascade among gay, bisexual and other men who have sex with men in Canada.

J Int AIDS Soc 2018 Nov;21(11):e25211

Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, ON, Canada.

Introduction: Notwithstanding the efficacy of oral pre-exposure prophylaxis (PrEP) in clinical trials, a number of obstacles exist to achieving population-level impact among gay, bisexual and other men who have sex with men (GBM). However, few studies have explored the subjective experiences of GBM PrEP users and non-users in the community, outside of clinical trials. The objectives of this study were to explore GBM's experiences of considering, accessing and using (or not using) PrEP, and to understand emerging sexual health, social and community issues among GBM in the PrEP era. Read More

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http://doi.wiley.com/10.1002/jia2.25211
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http://dx.doi.org/10.1002/jia2.25211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253066PMC
November 2018
13 Reads

90-90-90 by 2020? Estimation and projection of the adult HIV epidemic and ART programme in Zimbabwe - 2017 to 2020.

J Int AIDS Soc 2018 Nov;21(11):e25205

Institute for Global Health, UCL, London, UK.

Introduction: The 90-90-90 targets set by the United Nations aspire to 73% of people living with HIV (PLHIV) being virally suppressed by 2020. Using the HIV Synthesis Model, we aim to mimic the epidemic in Zimbabwe and make projections to assess whether Zimbabwe is on track to meet the 90-90-90 targets and assess whether recently proposed UNAIDS HIV transition metrics are likely to be met.

Methods: We used an approximate Bayesian computation approach to identify model parameter values which result in model outputs consistent with observed data, evaluated using a calibration score. Read More

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http://dx.doi.org/10.1002/jia2.25205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250855PMC
November 2018
15 Reads

Previous incarceration impacts access to hepatitis C virus (HCV) treatment among HIV-HCV co-infected patients in Canada.

J Int AIDS Soc 2018 Nov;21(11):e25197

Division of Infectious Diseases/Chronic Viral Illness Service, Department of Medicine, Glen site, McGill University Health Centre, Montreal, QC, Canada.

Introduction: The prevalence of hepatitis C virus (HCV) is far higher in prison settings than in the general population; thus, micro-elimination strategies must target people in prison to eliminate HCV. We aimed to examine incarceration patterns and determine whether incarceration impacts HCV treatment uptake among Canadian HIV-HCV co-infected individuals in the direct-acting antiviral (DAA) era.

Methods: The Canadian Co-Infection Cohort prospectively follows HIV-HCV co-infected people from 18 centres. Read More

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http://dx.doi.org/10.1002/jia2.25197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246945PMC
November 2018
10 Reads
5.090 Impact Factor

Retention in care among clinically stable antiretroviral therapy patients following a six-monthly clinical consultation schedule: findings from a cohort study in rural Malawi.

J Int AIDS Soc 2018 Nov;21(11):e25207

Epicentre, Paris, France.

Introduction: Longer intervals between clinic consultations for clinically stable antiretroviral therapy (ART) patients may improve retention in care and reduce facility workload. We assessed long-term retention among clinically stable ART patients attending six-monthly clinical consultations (SMCC) with three-monthly fast-track drug refills, and estimated the number of consultations "saved" by this model of ART delivery in rural Malawi.

Methods: Stable patients (aged ≥18 years, on first-line ART ≥12 months, CD4 count ≥300 cells/mL , without opportunistic infections, not pregnant/breastfeeding) were eligible for SMCC, with three-monthly drug refills from community health workers. Read More

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http://dx.doi.org/10.1002/jia2.25207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240757PMC
November 2018
7 Reads

Predictive factors associated with liver fibrosis and steatosis by transient elastography in patients with HIV mono-infection under long-term combined antiretroviral therapy.

J Int AIDS Soc 2018 Nov;21(11):e25201

Laboratory of Clinical Research in STI/AIDS (LAPCLIN-AIDS), National Institute of Infectious Diseases Evandro Chagas-Oswaldo Cruz Foundation (INI/FIOCRUZ), Rio de Janeiro, Brazil.

Introduction: Non-alcoholic fatty liver disease is characterized by the presence of hepatic steatosis and can be associated with fibrosis progression, development of cirrhosis and liver-related complications. Data on the prevalence of liver fibrosis and steatosis in HIV patients remain contradictory in resource-limited settings. We aimed to describe the prevalence and factors associated with liver fibrosis and steatosis in patients with HIV mono-infection under long-term antiretroviral therapy (ART) in Rio de Janeiro, Brazil. Read More

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http://doi.wiley.com/10.1002/jia2.25201
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http://dx.doi.org/10.1002/jia2.25201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216177PMC
November 2018
9 Reads

Repeated rectal application of a hyperosmolar lubricant is associated with microbiota shifts but does not affect PrEP drug concentrations: results from a randomized trial in men who have sex with men.

J Int AIDS Soc 2018 Oct;21(10):e25199

Division of Infectious Diseases, Department of Medicine, The Hope Clinic of the Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

Introduction: Oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is highly effective in preventing HIV infection among men who have sex with men (MSM). The effects of consistent personal lubricant use in the rectum on tissue PrEP drug concentrations and the rectal microbiota are unknown. We investigated rectal PrEP drug concentrations and the microbiota in MSM before and after repeated rectal application of a hyperosmolar lubricant. Read More

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http://doi.wiley.com/10.1002/jia2.25199
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http://dx.doi.org/10.1002/jia2.25199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207839PMC
October 2018
5 Reads
5.090 Impact Factor

Development of sensitive ddPCR assays to reliably quantify the proviral DNA reservoir in all common circulating HIV subtypes and recombinant forms.

J Int AIDS Soc 2018 Sep;21(9):e25185

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: The latent reservoir is the main barrier on the road to HIV cure, and clinical approaches towards eradication are often evaluated by their effect on proviral DNA. To ensure inclusiveness and representativeness in HIV cure studies, proviral DNA quantification assays that are able to detect all common circulating HIV clades are urgently needed. Here, three HIV DNA assays targeting three different genomic regions were evaluated for their sensitivity and subtype-tolerance using digital PCR. Read More

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http://doi.wiley.com/10.1002/jia2.25185
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http://dx.doi.org/10.1002/jia2.25185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138437PMC
September 2018
8 Reads

Internalized HIV stigma, ART initiation and HIV-1 RNA suppression in South Africa: exploring avoidant coping as a longitudinal mediator.

J Int AIDS Soc 2018 Oct;21(10):e25198

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Introduction: Cross-sectional evidence suggests that internalized HIV stigma is associated with lower likelihoods of antiretroviral therapy (ART) initiation and HIV-1 RNA suppression among people living with HIV (PLWH). This study examined these associations with longitudinal data spanning the first nine months following HIV diagnosis and explored whether avoidant coping mediates these associations.

Methods: Longitudinal data were collected from 398 South African PLWH recruited from testing centres in 2014 to 2015. Read More

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http://doi.wiley.com/10.1002/jia2.25198
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http://dx.doi.org/10.1002/jia2.25198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202800PMC
October 2018
4 Reads

Regional differences between people who inject drugs in an HIV prevention trial integrating treatment and prevention (HPTN 074): a baseline analysis.

J Int AIDS Soc 2018 Oct;21(10):e25195

Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA.

Introduction: People who inject drugs (PWID) experience high HIV incidence and face significant barriers to engagement in HIV care and substance use treatment. Strategies for HIV treatment as prevention and substance use treatment present unique challenges in PWID that may vary regionally. Understanding differences in the risk structure for HIV transmission and disease progression among PWID is essential in developing and effectively targeting intervention strategies of HIV treatment as prevention. Read More

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http://dx.doi.org/10.1002/jia2.25195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198168PMC
October 2018
4 Reads

Successes and challenges in optimizing the viral load cascade to improve antiretroviral therapy adherence and rationalize second-line switches in Swaziland.

J Int AIDS Soc 2018 Oct;21(10):e25194

Research Department, Médecins Sans Frontières, Mbabane, Swaziland.

Introduction: As antiretroviral therapy (ART) is scaled up, more patients become eligible for routine viral load (VL) monitoring, the most important tool for monitoring ART efficacy. For HIV programmes to become effective, leakages along the VL cascade need to be minimized and treatment switching needs to be optimized. However, many HIV programmes in resource-constrained settings report significant shortfalls. Read More

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http://doi.wiley.com/10.1002/jia2.25194
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http://dx.doi.org/10.1002/jia2.25194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198167PMC
October 2018
9 Reads

Bioinformatic data processing pipelines in support of next-generation sequencing-based HIV drug resistance testing: the Winnipeg Consensus.

J Int AIDS Soc 2018 Oct;21(10):e25193

IrsiCaixa AIDS Research Institute, Badalona, Catalonia, Spain.

Introduction: Next-generation sequencing (NGS) has several advantages over conventional Sanger sequencing for HIV drug resistance (HIVDR) genotyping, including detection and quantitation of low-abundance variants bearing drug resistance mutations (DRMs). However, the high HIV genomic diversity, unprecedented large volume of data, complexity of analysis and potential for error pose significant challenges for data processing. Several NGS analysis pipelines have been developed and used in HIVDR research; however, the absence of uniformity in data processing strategies results in lack of consistency and comparability of outputs from different pipelines. Read More

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http://dx.doi.org/10.1002/jia2.25193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198166PMC
October 2018

Collateral benefits: how the practical application of Good Participatory Practice can strengthen HIV research in sub-Saharan Africa.

J Int AIDS Soc 2018 Oct;21 Suppl 7:e25175

Wits RHI, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: The Good Participatory Practice (GPP): Guidelines for Biomedical HIV Prevention Trials, second edition (2011) were developed to provide clinical trial sponsors and implementers with a formal stakeholder engagement framework. As one of the largest African research institutes, Wits Reproductive Health and HIV Institute (Wits RHI) became an early adopter of GPP by implementing its principles within large-scale national and regional clinical trials. This article examines Wits RHI's lessons learned from implementing GPP, its ongoing efforts to institutionalize GPP, and the yet to be realized potential in creating fully sustainable structures for meaningful stakeholder engagement in HIV prevention research, implementation science and beyond. Read More

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http://dx.doi.org/10.1002/jia2.25175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193316PMC
October 2018
2 Reads

Power to participants: a call for person-centred HIV prevention services and research.

J Int AIDS Soc 2018 Oct;21 Suppl 7:e25167

International HIV/AIDS Alliance, Brighton & Hove, United Kingdom.

Introduction: While biomedical HIV prevention offers promise for preventing new HIV infections, access to and uptake of these technologies remain unacceptably low in some settings. New models for delivery of HIV prevention are clearly needed. This commentary highlights the potential of person-centred programming and research for increasing the cultural relevance, applicability and use of efficacious HIV prevention strategies. Read More

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http://dx.doi.org/10.1002/jia2.25167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193315PMC
October 2018