5,084 results match your criteria Journal of the Formosan Medical Association = Taiwan yi zhi[Journal]


Cognitive impairment in patients with end-stage renal disease: Accelerated brain aging?

J Formos Med Assoc 2019 Feb 7. Epub 2019 Feb 7.

Institute of Public Health, School of Medicine, National Yang Ming University, Taipei, Taiwan; Preventive Medicine Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background: Chronic kidney disease exhibits a prominent premature aging phenotype in many different organ systems, including the brain. Nevertheless, a comprehensive characterization of brain aging in non-demented patients with end-stage renal disease (ESRD) is lacking and it remains unclear if the collective changes of cognitive functions and brain structures in ESRD is compatible with aging.

Methods: We compared 56 non-demented, independently living dialysis patients (mean age 59. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.011DOI Listing
February 2019
1 Read

Predisposing factors of necrotizing fasciitis with comparison to cellulitis in Taiwan: A nationwide population-based case-control study.

J Formos Med Assoc 2019 Feb 6. Epub 2019 Feb 6.

Division of Plastic Surgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan. Electronic address:

Background: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with low incidence that requires prompt surgery. In the initial stage, it is difficult to distinguish NF and cellulitis, and limited population-based reports are available.

Methods: We queried inpatient data sets of National Health Institute Research Database in Taiwan from 2002 to 2011 for all patients with diagnoses of NF. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.014DOI Listing
February 2019
1 Read

Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.

J Formos Med Assoc 2019 Feb 5. Epub 2019 Feb 5.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.

Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.016DOI Listing
February 2019
1 Read

Emergency department utilization and resuscitation rate among patients receiving maintenance hemodialysis.

J Formos Med Assoc 2019 Jan 31. Epub 2019 Jan 31.

Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Background: End-stage renal disease (ESRD) is a growing global health concern with increased disease burden and high medical costs. Utilization of the emergency department (ED) among dialyzed patients and the associated risk factors remain unknown.

Methods: Participants of this study, selected from the National Health Insurance Database in Taiwan, were aged 19-90 years and received maintenance hemodialysis from January 1, 2010, to December 31, 2010. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183066
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http://dx.doi.org/10.1016/j.jfma.2019.01.007DOI Listing
January 2019
1 Read

Modulation of parietal cytokine and chemokine gene profiles by mesenchymal stem cell as a basis for neurotrauma recovery.

J Formos Med Assoc 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, Chi Mei Medical Center, Tainan 710, Taiwan. Electronic address:

Background & Purpose: Following traumatic brain injury (TBI), primary mechanical injury to the brain may cause blood-brain-barrier damage followed by secondary injury, ultimately culminating in cell death. We aimed to test whether one injection of mesenchymal stem cells (MSC) derived from the human umbilical cord can modulate brain cytokine and chemokine gene profiles and attenuate neurological injury in rats with TBI.

Methods: One-day post-TBI, the injured rats were treated with one injection of MSC (4 × 10/rat, i. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.008DOI Listing
January 2019
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Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy.

J Formos Med Assoc 2019 Jan 29. Epub 2019 Jan 29.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: The irradiation of 660-nm light-emitting diodes (LEDs) has exhibited potential to accelerate oral wound healing and prevent periodontal breakdown in rodents. This study was to evaluate the clinical effectiveness of 660-nm LEDs during non-surgical periodontal therapy (NSPT).

Methods: Nineteen patients with at least one periodontitis-involved tooth in three quadrants received NSPT, and three protocols of LED light irradiation, including LED light irradiation from initial clinical assessment (T0) until the completion of scaling and root planning (T1) (LED01), LED light irradiation from T1 until re-evaluation (T2) (LED02), and no LED light irradiation (control treatment), were randomly assigned to respective quadrant. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.010DOI Listing
January 2019
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Integration of imaging and molecular approaches in selective fetal reduction in twin pregnancies with one carrying a pathogenic genomic aberration.

J Formos Med Assoc 2019 Jan 29. Epub 2019 Jan 29.

Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital and Department of Genomic Science and Technology, Changhua Christian Hospital Healthcare System, Changhua, Taiwan; Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan; Department of Medical Research, Changhua Christian Hospital, Changhua, Taiwan; Department of Molecular Biotechnology, Dayeh University, Changhua, Taiwan. Electronic address:

Background/purpose: With the evolution of assisted fertility and prenatal diagnostic technology, the prevalence of multi-fetal pregnancy increased, followed by the demand for prenatal intervention if genomic aberration was detected. How to distinguish the affected foetus from the normal co-twin before selective fetal reduction is therefore challenging.

Objectives: We retrospectively reviewed the cases of dichorionic twins at our centre during 2004-2018, where selective fetal reduction was requested because one foetus carried a pathogenic genomic aberration. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.009DOI Listing
January 2019
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Successful management of type IV hypersensitivity reactions to human insulin analogue with injecting mixtures of biphasic insulin aspart and dexamethasone.

J Formos Med Assoc 2019 Jan 28. Epub 2019 Jan 28.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Although hypersensitivity reaction to insulin was supposed to be less-frequent with current insulin analogue, case reports with different types of allergic reactions to insulin analogue were still reported. The most common form is type I hypersensitivity reaction with IgE-mediated. Besides, type III (IgG and IgM-mediated) and type IV (T-cell mediated delayed reaction) hypersensitivity reactions were also reported. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.004DOI Listing
January 2019
1 Read

Reply to: "The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease".

J Formos Med Assoc 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09296646193001
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http://dx.doi.org/10.1016/j.jfma.2019.01.006DOI Listing
January 2019
6 Reads

The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease.

J Formos Med Assoc 2019 Jan 19. Epub 2019 Jan 19.

Unit of Gastroenterology and Hepatology, Molinette-SGAS Hospital, Turin, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183092
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http://dx.doi.org/10.1016/j.jfma.2019.01.005DOI Listing
January 2019
4 Reads

The effectiveness of music therapy for individuals with Rett syndrome and their families.

J Formos Med Assoc 2019 Jan 19. Epub 2019 Jan 19.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: Patients with Rett syndrome (RTT) present characteristic regression in communication and hand skills, which eventually leads to intellectual and physical disability. Moreover, caregivers of patients with RTT face stressors related to patients' medical and developmental concerns. Given the indications from case reports, this pilot study investigated the effectiveness of music therapy on RTT patients, as well as on parental stress for families of children with RTT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183042
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http://dx.doi.org/10.1016/j.jfma.2019.01.001DOI Listing
January 2019
2 Reads

Early timing of single balloon enteroscopy is associated with increased diagnostic yield in patients with overt small bowel bleeding.

J Formos Med Assoc 2019 Jan 17. Epub 2019 Jan 17.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Although performing balloon enteroscopy soon after the onset of small bowel bleeding appeared to enhance diagnostic rate, the optimal timing was unclear.

Methods: A retrospective cohort study in a single referral center. Patients with overt, suspected small bowel bleeding who underwent primary single-balloon enteroscopy (SBE) were evaluated to determine the association between procedure timing and diagnostic yield rates. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.003DOI Listing
January 2019
1 Read

Microbiota and gastrointestinal cancer.

J Formos Med Assoc 2019 Jan 14. Epub 2019 Jan 14.

Departments of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. Electronic address:

Gut microbiota plays important roles in many diseases, including cancer. It may promote carcinogenesis by inducing oxidative stress, genotoxicity, host immune response disturbance, and chronic inflammation. Colorectal cancer, hepatocellular carcinoma, and gastric cancer are the major gastrointestinal tract cancers in Taiwan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183092
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http://dx.doi.org/10.1016/j.jfma.2019.01.002DOI Listing
January 2019
3 Reads

Seasonal influenza prevention and control in Taiwan-Strategies revisited.

J Formos Med Assoc 2019 Jan 12. Epub 2019 Jan 12.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Influenza remains a serious public health threat in Taiwan. During 2017-18, Taiwan experienced two seasonal influenza epidemics caused by A/H3N2 and B, respectively. In addition to national influenza vaccination campaign, Taiwan Centers for Diseases Control and Infectious Disease Control Advisory Committee has multi-faceted strategies for seasonal influenza prevention and control to mitigate the risk of disease transmission among vulnerable groups and decrease influenza-related morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183077
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http://dx.doi.org/10.1016/j.jfma.2018.12.022DOI Listing
January 2019
3 Reads

The impact of orbital bony or fat decompression on the outcome of strabismus surgery in patients with Graves' ophthalmopathy.

J Formos Med Assoc 2019 Jan 7;118(1 Pt 3):387-394. Epub 2018 Jul 7.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; School of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: To compare the outcomes of strabismus surgery in patients with Graves' ophthalmopathy (GO) who had undergone bone removal orbital decompression (BROD) or fat removal orbital decompression (FROD) with those who had not undergone any orbital decompression.

Methods: The records of patients with GO who underwent strabismus surgery over a period of 66 months were retrospectively reviewed.

Results: Eighty-nine patients with a mean age of 55. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.06.009DOI Listing
January 2019
2 Reads

The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy.

J Formos Med Assoc 2019 Jan 10. Epub 2019 Jan 10.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: The binding of anti-phospholipase A2 receptor (anti-PLA2R) antibody to podocyte and complement activation is the mechanisms of idiopathic membranous nephropathy (IMN). C5a, a complement activation end product, is a strong inflammatory cell stimulator and can influence the behavior of T cells and dendritic cells. This study examined the etiology-disease relationship and significance of auto-antibody and C5a with short-term remission. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183073
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http://dx.doi.org/10.1016/j.jfma.2018.12.026DOI Listing
January 2019
8 Reads

Does one-man method better than two-man method for colonoscopy insertion in children.

J Formos Med Assoc 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: One-man method had shown several advantages over two-man method in adult colonoscopy insertion. However, whether this advantage can be extended to children is largely unknown. The aim of this study is to test the hypothesis that one-man method is the preferred method to two-man method in pediatric colonoscopy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183070
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http://dx.doi.org/10.1016/j.jfma.2018.12.024DOI Listing
January 2019
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Tuberculosis case finding: Supplement intensified case finding among acute lower respiratory infection (ALRI) hospitalized patients in Sa Kaeo province, Thailand.

J Formos Med Assoc 2019 Jan 9. Epub 2019 Jan 9.

Department of Epidemiology, Faculty of Public Health, Mahidol University, Thailand. Electronic address:

Background And Purpose: We aimed to estimate TB prevalence among in-patients hospitalized with acute lower respiratory infection (ALRI) through a routine TB case finding approach (Patient-Initiated-Pathway, PIP) and among those without initial TB detection by PIP using a supplementary-Intensified-Case-Finding (supplementary-ICF) approach to determine the extent of active TB infection in patients enrolled in population-based surveillance in Sa Keao, Thailand. We also investigated secondary TB transmission through household contacts (HHCs).

Methods: This was a prospective cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.016DOI Listing
January 2019

Etiologies and clinical characteristics of non-obstructive dysphagia in a Taiwanese population: A prospective study based on high-resolution impedance manometry.

J Formos Med Assoc 2019 Jan 8. Epub 2019 Jan 8.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: Esophageal motility disorders are the major cause of non-obstructive dysphagia (NOD), but may be underdiagnosed. In this high-resolution impedance manometry (HRIM)-based study, we aimed to clarify the etiologies and clinical characteristics of patients presenting with NOD in a Taiwanese population.

Methods: From October 2014 to July 2017, consecutive patients with the chief complaint of dysphagia were prospectively enrolled in the study at a tertiary medical center. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.019DOI Listing
January 2019
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Traumatic dislocation of the mandibular condyle into the middle cranial fossa treated by an intraoral approach.

J Formos Med Assoc 2019 Jan 7. Epub 2019 Jan 7.

Department of Dentistry, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan. Electronic address:

Dislocation of the mandibular condyle is one of several consequences of facial trauma that can be anticipated. The condylar neck is inherently weak and likely to fracture at the time of impact before dislocating into the middle cranial fossa. A review of the literature revealed that most cases of dislocation of the mandibular condyle into the middle cranial fossa are treated by open reduction and internal fixation via an extraoral approach or are treated conservatively with closed reduction. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.025DOI Listing
January 2019

Blood loss and operative time associated with orthognathic surgery utilizing a novel navigation system in cleft lip and palate patients.

J Formos Med Assoc 2019 Jan 7. Epub 2019 Jan 7.

Department of Craniofacial Orthodontics, Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Purpose: This retrospective study evaluated the volume of blood loss and operative time associated with management of nongrowing patients with cleft lip and palate (CLP) using bimaxillary orthognathic surgery (OGS) designed by a three-dimensional (3D) computer-assisted simulation and navigation for orthognathic surgery (CASNOS) system.

Methods: This study included 53 skeletal Class III nongrowing patients with unilateral CLP who underwent bimaxillary OGS using either the CASNOS protocol (n = 30) or the traditional two-dimensional (2D) method (n = 23). The skeletal parameters of jaw-bone components, the levels of hemoglobin (Hb) and hematocrit (Hct) were measured before and after surgery. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.011DOI Listing
January 2019

Outcomes research and quality improvement for the global Asian populations: Opportunity for Taiwan.

J Formos Med Assoc 2019 Jan 7. Epub 2019 Jan 7.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2018.12.021DOI Listing
January 2019

Post-transplantation lymphoproliferative disease in pediatric liver recipients in Taiwan.

J Formos Med Assoc 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, National Taiwan University Hospital, No. 8, Chung-Shan S. Rd., Taipei, Taiwan. Electronic address:

Background: Post-transplantation lymphoproliferative disorder (PTLD) is a heterogeneous, potentially life-threatening complication after liver transplantation in children. In this study, the disease characteristics, outcomes, and prognostic factors of PTLD were investigated.

Methods: A retrospective, observational study was conducted on 16 pediatric liver transplant (LT) recipients who developed PTLD between February 2001 and December 2013 at a tertiary referral center in Taiwan. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.023DOI Listing
January 2019
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Resident burnout in Taiwan Hospitals-and its relation to physician felt trust from patients.

J Formos Med Assoc 2019 Jan 7. Epub 2019 Jan 7.

Institute of Public Health, National Yang-Ming University, No.155, Sec. 2, Linong St., Beitou Dist, Taipei, Taiwan. Electronic address:

Background/purpose: This study hypothesized that low 'felt trust' from patients may induce resident burnout. The authors developed and validated a scale to measure physician felt trust from patients and surveyed residents in Taiwan to estimate the prevalence of burnout, and to verify the association between felt trust and burnout.

Methods: Residents in Taiwan were surveyed between November 2015 and May 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646173080
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http://dx.doi.org/10.1016/j.jfma.2018.12.015DOI Listing
January 2019
1 Read

Transient elastography correlated with diffusion-weighted magnetic resonance imaging and cholestatic complications.

J Formos Med Assoc 2019 Jan 6. Epub 2019 Jan 6.

Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: The study aim to investigate the correlation between diffusion-weighted magnetic resonance imaging (DW-MRI) and transient elastography (TE) liver fibrosis findings in children with cholestatic liver diseases, and the utility of TE findings to predict cholestatic complications in children.

Methods: This cross-sectional study enrolled 36 cholestatic children (21 boys and 15 girls). All study subjects underwent TE and DW-MRI studies to assess liver stiffness. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.018DOI Listing
January 2019

Noisy breathing sounds - A life-threatening cause of an infant with a vallecular cyst.

J Formos Med Assoc 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, National Taiwan University Children Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2018.12.020DOI Listing
January 2019

Prenatal diagnosis of paternal uniparental disomy for chromosome 14 using a single-nucleotide-polymorphism-based microarray analysis: A case report.

J Formos Med Assoc 2019 Jan 4. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Paternal uniparental disomy 14 (UDP(14)pat) is a rare imprinting disorder with a set of unique neonatal clinical features documented, including craniofacial abnormalities, thoracic and abdominal wall defects, and polyhydraminos. To date, no studies focus on prenatal diagnosis of uniparental disomy have been published. We report a case of a fetus with abnormal ultrasound features at 18 weeks of gestation and normal karyotype result. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.010DOI Listing
January 2019
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Factors associated with long-term progression of pediatric chronic kidney disease of nonglomerular etiologies.

J Formos Med Assoc 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng-Kung University Hospital, College of Medicine, Tainan, Taiwan. Electronic address:

Background/purpose: The aims of this study were to determine the long-term associated factors for chronic kidney disease (CKD) progression in a pediatric group with non-glomerular (non-GN) etiologies.

Methods: Pediatric patients with a presumptive diagnosis of CKD were enrolled to this study. Recorded information included demographic and laboratory information. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.016DOI Listing
January 2019

A case of recalcitrant pediatric Vogt-Koyanagi-Harada disease successfully controlled with adalimumab.

J Formos Med Assoc 2019 Jan 5. Epub 2019 Jan 5.

Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai, New York, USA; Midtown Ophthalmology, P.C. Manhattan, New York, USA.

Vogt-Koyanagi-Harada (VKH) disease is uncommon in the pediatric population and can have an aggressive course with serious visual sequelae. A 12-year-old Han Chinese American female, who presented with mild headaches and panuveitis with diffuse serous retinal detachments, was diagnosed with VKH. Despite treatment with a combination of high-dose systemic corticosteroids, intravitreal triamcinolone injection, and mycophenolate mofetil, ocular inflammation was inadequately controlled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183065
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http://dx.doi.org/10.1016/j.jfma.2018.12.014DOI Listing
January 2019
5 Reads

Advanced physical examination training course improves medical students' confidence in physical examination.

J Formos Med Assoc 2019 Jan 3. Epub 2019 Jan 3.

Department of Internal Medicine, National Taiwan University College of Medicine, and National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: Physical examination (PE) is a basic diagnostic tool in clinical settings. It is important to enhance medical students' skills and confidence in PE.

Subjects And Methods: Our medical students begin learning PE in the fourth medical year (M4). Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.013DOI Listing
January 2019

A registry of acromegaly patients and one year following up in Taiwan.

J Formos Med Assoc 2019 Jan 3. Epub 2019 Jan 3.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: The objectives of this study were to describe epidemiological data, treatment outcomes, and quality of life (QOL) of patients with acromegaly in Taiwan.

Methods: From 2013 to 2015, subjects with acromegaly were recruited through five medical centers. After enrollment, each patient was kept on observation for 1 year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183054
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http://dx.doi.org/10.1016/j.jfma.2018.12.017DOI Listing
January 2019
3 Reads

Survival analysis of extracorporeal membrane oxygenation in neonatal and pediatric patients - A nationwide cohort study.

J Formos Med Assoc 2019 Jan 4. Epub 2019 Jan 4.

Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.

Background: Extracorporeal membrane oxygenation (ECMO) provides short-term cardiopulmonary support for patients with acute cardiac and respiratory failure. This study reported the survival rate for pediatric patients from Taiwan's national cohort.

Methods: Patients under the age of 18 who received ECMO from January 1, 2002 to December 31, 2012 were identified from the Taiwan National Health Insurance Research Database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183059
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http://dx.doi.org/10.1016/j.jfma.2018.12.008DOI Listing
January 2019
8 Reads

Roles of Epstein-Barr virus viral load monitoring in the prediction of posttransplant lymphoproliferative disorder in pediatric liver transplantation.

J Formos Med Assoc 2019 Jan 3. Epub 2019 Jan 3.

Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: This study is aimed to investigate the risk factors and clinical characteristics of posttransplant lymphoproliferative disorder (PTLD) after conducting Epstein-Barr virus (EBV) viral load monitoring in pediatric liver transplant (LT) patients in Taiwan, where EBV infection is endemic.

Methods: From 2007 to 2013, pediatric LT recipients who underwent EBV viral load monitoring within 3 months after LT were recruited in this study. The impact of clinical parameters-including age at LT, sex, peak EBV viral load and immunosuppressant levels after LT-on the risk of PTLD were assessed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183023
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http://dx.doi.org/10.1016/j.jfma.2018.12.007DOI Listing
January 2019
1 Read

Effectiveness and appropriateness in the application of office hysteroscopy.

J Formos Med Assoc 2019 Jan 2. Epub 2019 Jan 2.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital (Linkou), Tao-Yuan, Taiwan; Chang Gung University College of Medicine, Tao-Yuan, Taiwan.

With the advances in miniature instruments, office hysteroscopy on conscious patients has been the standard to explore the intrauterine pathology, with the ability to perform some minor procedures concomitantly. Patients usually appreciate the efficient "see and treat" procedures with such minimal discomfort that exempt from the inconvenience of going into the operating room and the need for anesthesia. However, controversies exist in the appropriateness of its application in some clinical situations. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.012DOI Listing
January 2019
2 Reads

Taiwanese depression questionnaire revisit: Factor structure and measurement invariance across genders.

J Formos Med Assoc 2018 Dec 29. Epub 2018 Dec 29.

Department of Public Health, College of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background/purpose: Taiwanese Depression Questionnaire (TDQ) was widely used in Taiwan to measure individuals' proneness to depression. In light of well-established gender differences in the manifestation of depression, TDQ's structure invariance and measurement invariance across genders were examined in this study.

Methods: Data from 2604 adults was analyzed. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.006DOI Listing
December 2018

Impact of concomitant dyspepsia and irritable bowel syndrome on symptom burden in patients with gastroesophageal reflux disease.

J Formos Med Assoc 2018 Dec 21. Epub 2018 Dec 21.

Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background: Patients with gastroesophageal reflux disease (GERD) frequently report symptoms like dyspepsia or/and irritable bowel syndrome (IBS). The aim of the study was to investigate the impact of symptom overlap on GERD symptom burden. We also investigate whether GERD overlapping dyspepsia or/and IBS would have different clinical and psychological features as compared with GERD alone. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.002DOI Listing
December 2018

2019 Taiwan Society of Lipids and Atherosclerosis expert consensus statement on statin intolerance.

J Formos Med Assoc 2018 Dec 21. Epub 2018 Dec 21.

Departments of Internal Medicine and Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Statin reduces low-density lipoprotein cholesterol and improves clinical outcomes in high risk patients. In general, statin is a safe and well-tolerated medication. However, varieties of adverse effects are reported in some patients and may interfere long-term drug compliance. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.017DOI Listing
December 2018

Application of high-fidelity simulation in critical care residency training as an effective learning, assessment, and prediction tool for clinical performance.

J Formos Med Assoc 2018 Dec 21. Epub 2018 Dec 21.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Medicine, National Taiwan University, College of Medicine, Taipei, Taiwan.

Background/purpose: This study was conducted to assess: 1) the impact of the HFS curriculum on residents' knowledge and skills, and 2) the correlation between learning outcomes and the clinical performance.

Methods: An HFS-based curriculum was implemented for junior residents prior to their ICU rotations. Residents completed written tests before (pre-test) and after (post-test) the curriculum and were assessed on their performance during the simulation sessions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183049
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http://dx.doi.org/10.1016/j.jfma.2018.12.003DOI Listing
December 2018
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Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients.

J Formos Med Assoc 2018 Dec 20. Epub 2018 Dec 20.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCAAG) and GPCA-negative AG (GPCAAG) patients.

Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCAAG, 780 GPCAAG patients, and 532 healthy control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183080
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http://dx.doi.org/10.1016/j.jfma.2018.12.005DOI Listing
December 2018
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Factors affecting serum concentration of dabigatran in Asian patients with non-valvular atrial fibrillation.

J Formos Med Assoc 2018 Dec 20. Epub 2018 Dec 20.

Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

Background/purpose: Dabigatran is effective in preventing ischemic stroke and systemic embolism in patients with atrial fibrillation. Although the therapeutic window for dabigatran is wide, its pharmacokinetic properties can differ between specific populations. This study aimed to establish a real-life plasma dabigatran concentration database and investigate potential factors affecting this concentration in Asians. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183059
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http://dx.doi.org/10.1016/j.jfma.2018.11.013DOI Listing
December 2018
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Timely eradication of HCV viremia by PegIFN/RBV is crucial in prevention of post RFA recurrence in CHC-HCC patients.

J Formos Med Assoc 2018 Dec 20. Epub 2018 Dec 20.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; College of Medicine, Chang Gung University, Taiwan. Electronic address:

Background: Secondary prevention of hepatocellular carcinoma (HCC) among patients with chronic hepatitis C (CHC) who achieve sustained virologic response (SVR) with interferon-based therapy has been proved effective. However, tertiary prevention with PegIFN/RBV therapy of HCC recurrence seems limited effect in CHC-HCC patients post curative therapies. This study aims to investigate the timing and impact of PegIFN/RBV treatment on prevention of HCC recurrence in patients after RFA treatment. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.014DOI Listing
December 2018
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Developing a novel cholesterol-based nanocarrier with high transfection efficiency and serum compatibility for gene therapy.

J Formos Med Assoc 2018 Dec 19. Epub 2018 Dec 19.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; National Taiwan University Hospital, Taipei, Taiwan; Molecular Imaging Center, National Taiwan University, Taipei, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Primary cells are sensitive to culture conditions, which can be more difficult to get efficient transfection. The purpose of this study is to develop a serum-compatible cholesterol-based nanocarrier for delivering therapeutic nucleic acids into cells efficiently for future clinical gene therapy.

Methods: A novel cationic 3-β-[N-(2-guanidinoethyl)carbamoyl]-cholesterol (GEC-Chol) was mixed with cholesterol and superparamagnetic iron oxide (SPIO) nanoparticles to form GCC-FeO nanocarrier. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.08.026DOI Listing
December 2018

Correlation between visual association memory test and structural changes in patients with Alzheimer's disease and amnestic mild cognitive impairment.

J Formos Med Assoc 2018 Dec 19. Epub 2018 Dec 19.

Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan. Electronic address:

Background: Visual association memory test (VAMT) is a brief 6-point cognition test that has been shown to be effective in differentiating Alzheimer's disease (AD) from other types of dementia. This study aimed to investigate the correlation of the VAMT performance with amyloid plaque burden and hippocampal atrophy.

Methods: Fourteen patients with AD, 29 with amnestic mild cognitive impairment (aMCI), and 11 normal cognition (NC) subjects were recruited. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.001DOI Listing
December 2018

PI3K inhibitor provides durable response in metastatic metaplastic carcinoma of the breast: A hidden gem in the BELLE-4 study.

J Formos Med Assoc 2018 Dec 18. Epub 2018 Dec 18.

Department of Oncology, National Taiwan University Hospital, Taiwan; Department of Oncology, National Taiwan University Cancer Center, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taiwan. Electronic address:

Purpose: Metaplastic carcinoma of the breast (MCB) is a rare cancer characterized by the histologic presence of two or more histological cell types originating from epithelial and mesenchymal stem cells. Patients with metastatic MCB have a low response rate to conventional chemotherapy and poor survival. Optimal treatment strategies for metastatic MCB are urgently needed. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.004DOI Listing
December 2018
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IL-1β-induced ICAM-1 and IL-8 expression/secretion of dental pulp cells is differentially regulated by IRAK and p38.

J Formos Med Assoc 2018 Dec 14. Epub 2018 Dec 14.

Department of Dentistry and School of Dentistry, National Taiwan University Hospital and National Taiwan University Medical College, Taiwan. Electronic address:

Background/purpose: Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine involved in the acute and chronic inflammatory processes of dental pulp. Intercellular adhesion molecule-1 (ICAM-1) and IL-8 are two major inflammatory mediators. However, the role of interleukin-1 receptor-associated kinases (IRAKs) signaling pathways in responsible for the inflammatory effects of IL-1β on dental pulp cells is not clear. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.015DOI Listing
December 2018
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Prognostic factors on outcomes of follicular thyroid cancer.

J Formos Med Assoc 2018 Dec 10. Epub 2018 Dec 10.

Division of Biostatistics, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address:

Purposes: We investigated the influences of prognostic factors on long-term survival of patients with follicular thyroid cancer (FTC) based on all-cause mortality and two exclusive causes of death, FTC and non-FTC.

Methods: In this retrospective cohort study, we collected data of 204 patients with FTC diagnosed between 1985 and 2007 at National Taiwan University Hospital. For all-cause mortality, Cox proportional hazards models were used to estimate hazard ratios for prognostic factors. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.010DOI Listing
December 2018

Nonintubated laryngomicrosurgery with Transnasal Humidified Rapid-Insufflation Ventilatory Exchange: A case series.

J Formos Med Assoc 2018 Dec 3. Epub 2018 Dec 3.

Department of Anesthesiology, National Taiwan University, College of Medicine and Hospital, No. 7, Chung-Shan S. Rd., Taipei, Taiwan. Electronic address:

Background: Nonintubation anaesthesia for laryngomicrosurgery (LMS) provides both excellent visualization of the surgical field and complete examination on vocal cord. However, adequate oxygenation remains challenging during nonintubated LMS. Recently, transnasal humidified rapid-insufflation ventilator exchange (THRIVE) has been reported effectively maintaining apneic oxygenation in patient with difficult airways. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.009DOI Listing
December 2018
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Clinical relevance of different handgrip strength indexes and cardiovascular disease risk factors: A cross-sectional study in suburb-dwelling elderly Chinese.

J Formos Med Assoc 2018 Dec 3. Epub 2018 Dec 3.

Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China; Department of Rehabilitation Medicine, Tianjin Medical University, Tianjin, China. Electronic address:

Background: Reduced muscle strength, as measured by handgrip strength (HS), has been associated with an increased risk of cardiovascular disease (CVD). The aim of this study was to examine the association between different HS indexes and CVD risk factors in elderly Chinese individuals. We also determine optimal cutoffs of HS indexes for predicting CVD risk factors. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.001DOI Listing
December 2018
1 Read

Guardian of economic security-National Pension Insurance.

Authors:
Chia-Yen Chung

J Formos Med Assoc 2019 Jan 24;118(1 Pt 1). Epub 2018 Oct 24.

National Chung Hsing University, National Pension Supervisory Committee Ministry of Health and Welfare, 5th Floor, No. 1, Nanhai Road, Zhongzheng District, Taipei, 10066, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2018.08.018DOI Listing
January 2019
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Efficacy and safety of 12 weeks of daclatasvir, asunaprevir plus ribavirin for HCV genotype-1b infection without NS5A resistance-associated substitutions.

J Formos Med Assoc 2018 Dec 4. Epub 2018 Dec 4.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background/purpose: Treatment with daclatasvir plus asunaprevir (DCV + ASV) for 24 weeks provided a sustained virologic response (SVR) rate of over 90% in hepatitis C virus genotype 1b (HCV-1b) infected patients without non-structural 5A (NS5A) resistance-associated substitutions (RASs) at the L31 and Y93 sites. In this study, we investigated whether adding ribavirin to the DCV + ASV combination could shorten the original treatment regimen to 12 weeks without compromising the treatment efficacy for HCV-1b patients without NS5A RASs.

Methods: In the prospective, open-label, single-arm, nationwide multi-center phase III study, a total of 70 interferon-naïve or interferon-experienced HCV-1b patients without baseline L31/Y93 RASs received daclatasvir (60 mg/day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks, with a 12-week post-treatment follow-up. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.11.007DOI Listing
December 2018