5,128 results match your criteria Journal of the Formosan Medical Association = Taiwan yi zhi[Journal]


Negative pressure pulmonary edema after vocal augmentation.

J Formos Med Assoc 2019 Apr 20. Epub 2019 Apr 20.

Department of Otolaryngology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.04.006DOI Listing

Pharmacotherapy and electroencephalographic evolution in SCN8A encephalopathy: A case report.

J Formos Med Assoc 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, National Taiwan University Children Hospital, National Taiwan University, Taipei, Taiwan; Department of Pediatric Neurology, National Taiwan University Children Hospital, National Taiwan University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.04.005DOI Listing

Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity.

J Formos Med Assoc 2019 Apr 17. Epub 2019 Apr 17.

Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA/TMAAG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA/TMAAG patients.

Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA/TMAAG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.04.002DOI Listing

Lower platelet count with increased density of platelet antigens in granulocyte colony-stimulating factor mobilized peripheral blood stem cell donors.

J Formos Med Assoc 2019 Apr 16. Epub 2019 Apr 16.

Department of Hematology and Oncology, Buddhist Hualien Tzu Chi Hospital, Hualien, Taiwan; Department of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background/purpose: Granulocyte colony-stimulating factor (G-CSF) is widely used for prophylaxis and treatment of neutropenia in cancer patients and also for peripheral blood stem cells (PBSC) mobilization. The aim of this study is to evaluate the possible changes of platelet surface antigens after G-CSF injection in PBSC donors compared with healthy control.

Methods: Between January 1st and December 31st, 2014, 48 healthy voluntary PBSC donors were eligible for this study. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.04.003DOI Listing

Three-dimensional cephalometry for orthognathic planning: Normative data and analyses.

J Formos Med Assoc 2019 Apr 16. Epub 2019 Apr 16.

Department of Plastic and Reconstructive Surgery, and Craniofacial Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background/purpose: The objective of this study was to create a normative database of 3D cephalometric measurements for adult Chinese in Taiwan to understand the specific features, as well as to provide information for 3-dimensional (3D) orthognathic surgery planning for patients with maxillofacial deformity.

Methods: A cross-sectional study was conducted on 30 male and 30 female adults with normal and balanced facial appearance, skeletal Class I pattern, and proper interincisal relationship with normal occlusion. Cone-beam computed tomography was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183067
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http://dx.doi.org/10.1016/j.jfma.2019.04.001DOI Listing
April 2019
4 Reads

The effects of losartan versus beta-blockers on cardiovascular protection in marfan syndrome: A systematic review and meta-analysis.

J Formos Med Assoc 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. Electronic address:

Background And Purpose: Variable effects of beta-blockers (BB) and/or angiotensin receptor blockers (ARB) were reported to retard aortic root growth in Marfan syndrome (MFS). This study aimed to compare the effects of BB therapy and ARB-related therapies on cardiovascular protection in MFS.

Methods: Studies of randomized control trials comparing the efficacy of only-BB and ARB-related (only-ARB or ARB-plus-BB) therapies for MFS published before July 31, 2018 in PubMed, Embase, and the Cochrane Library were selected. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.018DOI Listing

A community-based study on the application of fatty liver index in screening subjects with nonalcoholic fatty liver disease.

J Formos Med Assoc 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University at Keelung, Keelung, Taiwan; Community Medicine Research Center, Chang-Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Background/purpose: Nonalcoholic fatty liver disease (NAFLD) is now a global liver disease. The fatty liver index (FLI), which is calculated by the equation comprising waist circumference, body mass index (BMI), triglyceride, and gamma glutamyl transpeptidase (GGT), is frequently used for hepatic steatosis evaluation. This study aimed to evaluate the optimal cut-off point of FLI to select subjects for abdominal ultrasonography (US) screening for NAFLD in the community. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.016DOI Listing
April 2019
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Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative atrophic glossitis patients.

J Formos Med Assoc 2019 Apr 9. Epub 2019 Apr 9.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Our previous study found that 177 of 1064 atrophic glossitis (AG) patients have serum gastric parietal cell antibody (GPCA) positivity only (so-called GPCAAG patients). This study assessed whether serum GPCA positivity or AG itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCAAG or GPCA-negative, thyroglobulin antibody (TGA)-negative, and thyroid microsomal antibody (TMA)-negative AG (GPCA־TGA־TMA־AG) patients.

Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 177 GPCAAG patients, 476 GPCA־TGA־TMA־AG patients, and 532 healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.017DOI Listing
April 2019
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Reference levels for glucose-6-phosphate dehydrogenase enzyme activity in infants 7-90 days old in Taiwan.

J Formos Med Assoc 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. Electronic address:

Background: Nationwide newborn screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency has been implemented in Taiwan since 1987 and the G6PD enzyme activity levels were applied for diagnosis confirmation. As the reference value of G6PD enzyme activity was not available for infants aged 7-90 days, this study was performed to determine the enzyme level in different genotypes.

Methods: Between January 1, 2016 and June 30, 2017, 410 term infants aged 7-90 days old visiting National Taiwan University Hospital Hsinchu branch were enrolled. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.010DOI Listing

Reduction of blood pressure elevation by losartan in spontaneously hypertensive rats through suppression of LARG expression in vascular smooth muscle cells.

J Formos Med Assoc 2019 Apr 5. Epub 2019 Apr 5.

Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Cardiovascular Center, Fu Jen Catholic University College of Medicine and Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: This study sought to elucidate the mechanism by which losartan inhibits blood pressure (BP) elevation in spontaneously hypertensive rats (SHRs).

Methods: Four-week-old Wistar-Kyoto (WKY) rats and SHRs were either treated with losartan (20 mg/kg/day) for 8 weeks or served as untreated controls. BP was measured by the tail-cuff method. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.015DOI Listing
April 2019
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Role of mental health in the attitude toward same-sex marriage among people in Taiwan: Moderating effects of gender, age, and sexual orientation.

J Formos Med Assoc 2019 Apr 3. Epub 2019 Apr 3.

Department of Psychiatry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address:

Purpose: The aims of the study were to examine the role of mental health in peoples' attitude toward same-sex marriage in Taiwan, as well as the moderating effects of gender, age, and sexual orientation on the association between mental health and attitude toward same-sex marriage.

Methods: In total, 3235 participants were recruited through a Facebook advertisement. Each participant completed a questionnaire assessing attitude toward same-sex marriage and a 5-item Brief Symptom Rating Scale (BSRS-5). Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.011DOI Listing
April 2019
1.695 Impact Factor

Executive summary of the DAROC clinical practice guidelines for diabetes care- 2018.

J Formos Med Assoc 2019 Apr 2. Epub 2019 Apr 2.

It is estimated that there were 1.73-2.20 million people with diabetes in Taiwan in 2014-2015. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.016DOI Listing
April 2019
1 Read

Risk stratification of non-alcoholic fatty liver disease across body mass index in a community basis.

J Formos Med Assoc 2019 Apr 2. Epub 2019 Apr 2.

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address:

Background: The features and risk analysis of non-alcoholic fatty liver disease (NAFLD) in a community-based setting remain elusive. The predictors between obese and lean subjects need further clarification. We aimed to assess the characteristics of NAFLD during a community screening. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.014DOI Listing
April 2019
3 Reads

Snakebite (Protobothrops mucrosquamatus)-related myositis.

J Formos Med Assoc 2019 Mar 28. Epub 2019 Mar 28.

Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.03.013DOI Listing
March 2019
2 Reads

Characterization of a p.R76H mutation in Cx50 identified in a Chinese family with congenital nuclear cataract.

J Formos Med Assoc 2019 Mar 27. Epub 2019 Mar 27.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology &Visual Sciences Key Lab, Beijing, 100730, China. Electronic address:

Background/purpose: A three-generation Chinese family with autosomal dominant congenital nuclear cataract was recruited. This study aimed to identify the disease-causing gene for nuclear cataract with functional dissections of the identified mutant.

Methods: Detailed clinical data and family history were recorded. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.015DOI Listing

Major depressive episodes during pregnancy and after childbirth: A prospective longitudinal study in Taiwan.

J Formos Med Assoc 2019 Mar 27. Epub 2019 Mar 27.

College of Medicine, China Medical University, Taichung, Taiwan; Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan. Electronic address:

Background: Major depressive episodes (MDEs) are common during pregnancy and postpartum periods, and the consequences can be severe to mother and offspring. Few studies have investigated the clinical factors associated with the onset and remission of perinatal depression in different time points.

Methods: A cohort of 234 pregnant women was recruited and assessed with structured Mini-International Neuropsychiatric Interview (MINI) for diagnoses of MDEs. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.003DOI Listing
March 2019
3 Reads

miR-1246 as a therapeutic target in oral submucosa fibrosis pathogenesis.

J Formos Med Assoc 2019 Mar 28. Epub 2019 Mar 28.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan. Electronic address:

Background/purpose: Oral submucous fibrosis (OSF) is a precancerous condition of oral cancer with a complex etiology. Our previous work has demonstrated that non-coding RNA miR-1246 contributes to the cancer stemness of oral cancer. In the current study, we sought to investigate the effect of the inhibition of miR-1246 on the oral fibrogenesis. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.014DOI Listing
March 2019
2 Reads

Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease.

J Formos Med Assoc 2019 Mar 28. Epub 2019 Mar 28.

Division of Nephrology, Department of Medicine, Keelung Chang Gung Memorial Hospital, Taiwan. Electronic address:

Background/purpose: Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD).

Methods: We studied 147 patients with CKD stage 1-5 over a 3-year follow-up period. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.005DOI Listing
March 2019
1 Read

Complication rates after chorionic villus sampling and midtrimester amniocentesis: A 7-year national registry study.

J Formos Med Assoc 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Purpose: To assess the complication rates following chorionic villus sampling (CVS) and midtrimester amniocentesis in Taiwan.

Methods: This is a national registry-based cohort study from Taiwan. We included all women with singleton pregnancies who received either CVS (n = 1409) or midtrimester amniocentesis (n = 250,566) during 2006-2012. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.006DOI Listing
March 2019
2 Reads

Secular trends in the distribution of allogeneic blood components in Taiwan.

J Formos Med Assoc 2019 Mar 28. Epub 2019 Mar 28.

Head Office, Taiwan Blood Services Foundation, Taipei, Taiwan; Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Recent blood distribution profiles for transfusions in Taiwan have not been comprehensively documented. This study aimed to analyze trends in red blood cell (RBC), platelet, and plasma distribution rates, and compares these profiles with those in other countries. The distribution rates of RBC, platelets, and plasma in Taiwan during 2015 were 47. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.002DOI Listing
March 2019
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2018 TSOC guideline focused update on diagnosis and treatment of pulmonary arterial hypertension.

J Formos Med Assoc 2019 Mar 26. Epub 2019 Mar 26.

Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Pulmonary arterial hypertension (PAH) is characterized as a progressive and sustained increase in pulmonary vascular resistance, which may induce right ventricular failure. In 2014, the Working Group on Pulmonary Hypertension of the Taiwan Society of Cardiology (TSOC) conducted a review of data and developed a guideline for the management of PAH. In recent years, several advancements in diagnosis and treatment of PAH has occurred. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.009DOI Listing
March 2019
1 Read

Similarities and differences between IBS-C and FC with regards to symptomatology, sleep quality and psychological attributes.

J Formos Med Assoc 2019 Mar 25. Epub 2019 Mar 25.

Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background: Irritable bowel syndrome (IBS) and functional constipation (FC) are highly prevalent in the general population and have significant symptom overlap, while the clinical associations and psychological links between IBS and FC remains poorly understood. We aimed to compare the clinical, metabolic and psychological factors between patients with FC patients and constipation predominated IBS.

Methods: We consecutively enrolled 360 patients from the outpatient clinics of Hualien Tzu Chi medical center. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.017DOI Listing
March 2019
2 Reads

Treatment effectiveness of levamisole plus prednisolone on oral lichen planus patients with emphasis on levamisole-induced agranulocytosis or pancytopenia.

J Formos Med Assoc 2019 Mar 25. Epub 2019 Mar 25.

Oral Pathology and Family Dentistry Section, Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background/purpose: Physicians' and dentists' knowledge of levamisole-induced agranulocytosis or pancytopenia remains incomplete. This study aimed to evaluate the treatment effectiveness of levamisole plus prednisolone on oral lichen planus (OLP) patients with emphasis on levamisole-induced hematological changes.

Methods: Ninety patients with erosive OLP were given 120 mg/day new levamisole (Levazol) and 15 mg/day prednisolone for three consecutive days each week. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.007DOI Listing
March 2019
3 Reads

Ethnic disparity in prevalence and associated risk factors of myopia in adolescents.

J Formos Med Assoc 2019 Mar 22. Epub 2019 Mar 22.

Department of Ophthalmology, Sin-Lau Hospital, No. 57, Sec. 1, Dongmen Rd., East Dist., Tainan City, 70142, Taiwan.

Background/purpose: To examine ethnic disparity in prevalence and associated factors of myopia in adolescents using the Unites States National Health and Nutrition Examination Survey (NHANES) dataset.

Methods: Participants who were aged 12-19 years were included from NHANES (1999-2008). Logistic regression analyses were applied to identify risk factors associated with myopia after stratification by race. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.004DOI Listing
March 2019
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Utility of apolipoprotein measurements in predicting incident type 2 diabetes: A Chinese cohort study.

J Formos Med Assoc 2019 Mar 21. Epub 2019 Mar 21.

Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, Republic of China; Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, Republic of China. Electronic address:

Background/purpose: There is conflicting data regarding the utility of measuring apolipoproteins in addition to traditional lipid measures in risk assessment of cardiometabolic diseases. The aim of this study was to determine whether apolipoprotein measurements can improve the ability to predict the future development of type 2 diabetes beyond what is possible based on traditional type 2 diabetes risk factors and clinical routine lipid measurements.

Methods: A total of 4,223 Chinese adults without diabetes were followed for a mean duration of 5. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.001DOI Listing
March 2019
1 Read

Role of the IL-15 system in ischemia stroke pathophysiology and therapeutic strategies.

J Formos Med Assoc 2019 Mar 16. Epub 2019 Mar 16.

Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.02.013DOI Listing

Outcome for surgical treatment of infective endocarditis with periannular abscess.

J Formos Med Assoc 2019 Mar 14. Epub 2019 Mar 14.

Department of Surgery, National Taiwan University Hospital, and National Taiwan University, College of Medicine, Taiwan. Electronic address:

Background: Surgical treatment of infective endocarditis (IE) with aortic periannular abscess (PA) is a challenging issue with high mortality and morbidity rate in the current era. The present study is to review the results of surgical treatment for IE-PA based on an anatomy-guided surgical procedure selection for either aortic valve replacement (AVR) or aortic root reconstruction (ARR).

Methods: Patients with IE-PA received surgical treatment in National Taiwan University Hospital during the years 2001-2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.009DOI Listing
March 2019
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Targeted temperature management in severe middle cerebral artery infarction-related out-of-hospital cardiac arrest.

J Formos Med Assoc 2019 Mar 13. Epub 2019 Mar 13.

Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.02.018DOI Listing

The correlation between fatty liver disease and chronic kidney disease.

J Formos Med Assoc 2019 Mar 12. Epub 2019 Mar 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background/purpose: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study.

Methods: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.010DOI Listing
March 2019
1.695 Impact Factor

Radiological features and outcomes of combined hepatocellular-cholangiocarcinoma in patients undergoing surgical resection.

J Formos Med Assoc 2019 Mar 12. Epub 2019 Mar 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background/purpose: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer. Preoperative diagnosis of cHCC-CCA is difficult, and outcome of cHCC-CCA is obscured. Our study aimed to investigate the clinicopathological and radiological features of cHCC-CCA and compare their outcomes with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.012DOI Listing
March 2019
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Reduction of healthcare costs by implementing palliative family conference with the decision to withdraw life-sustaining treatments.

J Formos Med Assoc 2019 Mar 12. Epub 2019 Mar 12.

Institute of Health Policy and Management, National Taiwan University, No. 17, Xu-Zhou Road, Taipei, 100, Taiwan; Institute of Health Behavior and Community Sciences, National Taiwan University, College of Public Health, No. 17, Xu-Zhou Road, Taipei, 100, Taiwan. Electronic address:

Background: Evidence regarding the impact of early palliative family conferences (PFCs) and decision to withdraw life-sustaining treatment (DTW) on healthcare costs in an intensive care unit (ICU) setting is inconsistent.

Methods: We retrospectively analyzed patients who died in an ICU from 2013 to 2016. PFCs held within 7 days after ICU admission and DTWs were verified by reviewing medical records and claims data. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.011DOI Listing

Similar outcomes between vitamin K and non-vitamin K antagonist oral anticoagulants associated intracerebral hemorrhage.

J Formos Med Assoc 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurology and Stroke Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: The application of non-vitamin K antagonist oral anticoagulant (NOAC) reduces the risk of intracerebral hemorrhage (ICH) in comparison with vitamin K antagonist (VKA). However, the features and outcomes of NOAC-associated ICH are still unclear, especially for Asian populations.

Methods: We retrospectively analyzed 49 consecutive patients who had spontaneous ICH while using NOAC or VKA. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.008DOI Listing

Bugs to debug? The exploration of gut microbiome in human health and diseases.

Authors:
Yen-Hsuan Ni

J Formos Med Assoc 2019 Mar;118 Suppl 1:S1-S2

Department of Pediatrics, Medical Microbiota Center, College of Medicine, National Taiwan University, Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.01.017DOI Listing

Computed tomography-guided dual localization with microcoil and patent blue vital dye for deep-seated pulmonary nodules in thoracoscopic surgery.

J Formos Med Assoc 2019 Mar 9. Epub 2019 Mar 9.

Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taiwan.

Background/purpose: In video-assisted thoracic surgery (VATS) resection of small lung nodules, preoperative dye marking around the visceral pleura provides surface localization to help initiate resection, while implantation of a fiducial marker such as a microcoil can provide inner localization to aid nodule resection under fluoroscopic guidance. We aimed to determine whether dual localization with microcoil placement and dye marking is safe and useful for guiding the resection of small deep-seated lung nodules.

Methods: We retrospectively evaluated data pertaining to 39 consecutive patients (40 nodules) managed between January 2016 and December 2017 in our hospital. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.005DOI Listing
March 2019
1.695 Impact Factor

Weaning outcome of solid cancer patients requiring mechanical ventilation in the intensive care unit.

J Formos Med Assoc 2019 Mar 8. Epub 2019 Mar 8.

Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan; Center of Sleep Disorder, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan.

Background: Whether the weaning outcome of solid cancer patients receiving mechanical ventilation (MV) in the intensive care unit (ICU) is comparable to that in non-cancer patients is unknown. The aim of this study was to compare the weaning outcomes between non-cancer patients and patients with different types of cancer.

Methods: We studied patients requiring MV during ICU stay for medical reasons between 2012 and 2014. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.007DOI Listing
March 2019
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Low-dose nab-paclitaxel-based combination chemotherapy in heavily pretreated pancreatic cancer patients.

J Formos Med Assoc 2019 Mar 7. Epub 2019 Mar 7.

Department of Oncology, National Taiwan University Hospital, Taiwan; Graduate Institutes of Clinical Medicine, National Taiwan University College of Medicine, Taiwan; Graduate Institutes of Oncology, National Taiwan University College of Medicine, Taiwan; National Taiwan University Cancer Center, Taiwan. Electronic address:

Background: Heavily pretreated pancreatic cancer patients have a grave prognosis. In this case series study, we evaluated the safety and efficacy of nab-paclitaxel-based chemotherapy for such patients.

Methods: The data of pancreatic adenocarcinoma patients (n = 40) treated with nab-paclitaxel after the failure of gemcitabine or fluoropyrimidines at our institution in 2013-2015 were reviewed. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.015DOI Listing
March 2019
2 Reads

Outcomes of severe H1N1 pneumoniae: A retrospective study at intensive care units.

J Formos Med Assoc 2019 Mar 7. Epub 2019 Mar 7.

Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: The incidence of acute respiratory distress syndrome (ARDS) and the mortality rate of H1N1 influenza pneumonia are unclear. The aim of this study is to investigate the clinical features and outcomes of adult patients admitted to intensive care units (ICUs) with H1N1 pneumonia related ARDS.

Methods: This retrospective study included patients with confirmed H1N1 influenza pneumonia admitted to the ICUs of a medical center between July 2009 and May 2014. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.006DOI Listing
March 2019
1 Read
1.695 Impact Factor

First report of a Mongolian family with spinocerebellar ataxia type I.

J Formos Med Assoc 2019 Feb 28. Epub 2019 Feb 28.

Clinical Neurological Center, First Central Hospital of Mongolia, Mongolia. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.02.003DOI Listing
February 2019

Pitfalls in cerebrospinal fluid analysis: A case report of carcinomatous meningitis mimicking infective causes.

J Formos Med Assoc 2019 Feb 27. Epub 2019 Feb 27.

Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.02.004DOI Listing
February 2019

The role of SLC9A3 in Taiwanese patients with congenital bilateral absence of vas deferens (CBAVD).

J Formos Med Assoc 2019 Feb 20. Epub 2019 Feb 20.

School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Congenital bilateral absence of vas deferens (CBAVD) is a special entity in obstructive azoospermia. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are involved in Taiwanese CBAVD but most heterozygous 5T variant. The solute carrier family 9 isoform 3 (SLC9A3) is the Na+/H+ exchanger, which interacts with CFTR and regulates the Ca2+ homeostasis. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.019DOI Listing
February 2019

Simultaneous auricular reconstruction and transcutaneous bone conduction device implantation in patients with microtia.

J Formos Med Assoc 2019 Feb 20. Epub 2019 Feb 20.

School of Medicine, Chang Gung University, Taoyuan, Taiwan; Craniofacial Research Center, Division of Craniofacial Surgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

Background/purpose: The Bonebridge (BB) is a newly designed transcutaneous bone conduction hearing implant. We describe, for the first time, simultaneous BB implantation and different surgical techniques of auricular reconstruction for microtia patients with aural atresia/stenosis.

Methods: Ten patients with unilateral or bilateral microtia underwent BB implantation combined simultaneously with either total auricular reconstruction using bespoke hand-carved Medpor framework or second stage auricular projection using autologous costal cartilage framework. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.013DOI Listing
February 2019

Assessing the change of anisometropia in unilateral myopic children receiving monocular orthokeratology treatment.

J Formos Med Assoc 2019 Feb 16. Epub 2019 Feb 16.

Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; Department of Ophthalmology and Visual Science, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background: This study aimed at comparing the inter-eye axial elongation difference in order to evaluate the change of anisometropia in unilateral myopic children wearing monocular orthokeratology (Ortho-K) lens.

Methods: In this retrospective cohort study, we recruited monocular myopic subjects treated with monocular Ortho-K lens from May 2012 to January 2017. The axial length (AL) of both eyes was recorded, and we calculated the AL difference as our primary outcome, to evaluate myopia progression. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.001DOI Listing
February 2019

Control and prevention of invasive pneumococcal disease in Taiwan: Current achievements and future challenges.

J Formos Med Assoc 2019 Feb 15. Epub 2019 Feb 15.

Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.01.020DOI Listing
February 2019

Taiwan's Nationwide Cancer Registry System of 40 years: Past, present, and future.

J Formos Med Assoc 2019 Feb 14. Epub 2019 Feb 14.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Taiwan Cancer Registry, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2019.01.012DOI Listing
February 2019
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Cognitive impairment in patients with end-stage renal disease: Accelerated brain aging?

J Formos Med Assoc 2019 Feb 7. Epub 2019 Feb 7.

Institute of Public Health, School of Medicine, National Yang Ming University, Taipei, Taiwan; Preventive Medicine Research Center, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background: Chronic kidney disease exhibits a prominent premature aging phenotype in many different organ systems, including the brain. Nevertheless, a comprehensive characterization of brain aging in non-demented patients with end-stage renal disease (ESRD) is lacking and it remains unclear if the collective changes of cognitive functions and brain structures in ESRD is compatible with aging.

Methods: We compared 56 non-demented, independently living dialysis patients (mean age 59. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.011DOI Listing
February 2019
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Predisposing factors of necrotizing fasciitis with comparison to cellulitis in Taiwan: A nationwide population-based case-control study.

J Formos Med Assoc 2019 Feb 6. Epub 2019 Feb 6.

Division of Plastic Surgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan. Electronic address:

Background: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with low incidence that requires prompt surgery. In the initial stage, it is difficult to distinguish NF and cellulitis, and limited population-based reports are available.

Methods: We queried inpatient data sets of National Health Institute Research Database in Taiwan from 2002 to 2011 for all patients with diagnoses of NF. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.014DOI Listing
February 2019
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Gastric parietal cell and thyroid autoantibodies in patients with atrophic glossitis.

J Formos Med Assoc 2019 Feb 5. Epub 2019 Feb 5.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of presence of serum GPCA, TGA, and TMA in atrophic glossitis (AG) patients.

Methods: Serum GPCA, TGA, and TMA levels were measured in 1064 AG patients and in 532 age- and sex-matched healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.016DOI Listing
February 2019
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Emergency department utilization and resuscitation rate among patients receiving maintenance hemodialysis.

J Formos Med Assoc 2019 Jan 31. Epub 2019 Jan 31.

Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Background: End-stage renal disease (ESRD) is a growing global health concern with increased disease burden and high medical costs. Utilization of the emergency department (ED) among dialyzed patients and the associated risk factors remain unknown.

Methods: Participants of this study, selected from the National Health Insurance Database in Taiwan, were aged 19-90 years and received maintenance hemodialysis from January 1, 2010, to December 31, 2010. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183066
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http://dx.doi.org/10.1016/j.jfma.2019.01.007DOI Listing
January 2019
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Modulation of parietal cytokine and chemokine gene profiles by mesenchymal stem cell as a basis for neurotrauma recovery.

J Formos Med Assoc 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, Chi Mei Medical Center, Tainan 710, Taiwan. Electronic address:

Background & Purpose: Following traumatic brain injury (TBI), primary mechanical injury to the brain may cause blood-brain-barrier damage followed by secondary injury, ultimately culminating in cell death. We aimed to test whether one injection of mesenchymal stem cells (MSC) derived from the human umbilical cord can modulate brain cytokine and chemokine gene profiles and attenuate neurological injury in rats with TBI.

Methods: One-day post-TBI, the injured rats were treated with one injection of MSC (4 × 10/rat, i. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.008DOI Listing
January 2019
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Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy.

J Formos Med Assoc 2019 Jan 29. Epub 2019 Jan 29.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: The irradiation of 660-nm light-emitting diodes (LEDs) has exhibited potential to accelerate oral wound healing and prevent periodontal breakdown in rodents. This study was to evaluate the clinical effectiveness of 660-nm LEDs during non-surgical periodontal therapy (NSPT).

Methods: Nineteen patients with at least one periodontitis-involved tooth in three quadrants received NSPT, and three protocols of LED light irradiation, including LED light irradiation from initial clinical assessment (T0) until the completion of scaling and root planning (T1) (LED01), LED light irradiation from T1 until re-evaluation (T2) (LED02), and no LED light irradiation (control treatment), were randomly assigned to respective quadrant. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.010DOI Listing
January 2019
2 Reads