7,774 results match your criteria Journal of the European Academy of Dermatology and Venereology[Journal]


Methylation and expression analysis of mismatch repair genes in extramammary Paget's disease.

J Eur Acad Dermatol Venereol 2019 Feb 19. Epub 2019 Feb 19.

Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China.

Background: Extramammary Paget's disease (EMPD) is a rare skin cancer with relative high frequencies of germline and somatic mismatch repair (MMR) genes mutations. However, the methylation and expression of these genes have not been validated in EMPD.

Objective: This study aims to confirm the methylation and expression of MMR genes in EMPD. Read More

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http://dx.doi.org/10.1111/jdv.15404DOI Listing
February 2019

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case-control study.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Atopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children.

Materials And Methods: All children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population. Read More

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http://dx.doi.org/10.1111/jdv.15413DOI Listing
February 2019

T cell-rich angiomatoid polypoid pseudolymphoma arising after local injury on the lip of a pregnant woman.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1111/jdv.15395DOI Listing
February 2019

Glomerular filtration rate in patients with moderate to severe psoriasis.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Psoriasis could be associated to comorbidities that can affect kidney function, including diabetes mellitus, arterial hypertension and hyperuricaemia. Chronic kidney disease (CKD) affects up to 10.4% of patients with psoriasis , and it is a risk factor for renal failure, cardiovascular diseases and overall mortality. Read More

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http://dx.doi.org/10.1111/jdv.15506DOI Listing
February 2019

Palisaded neutrophilic and granulomatous dermatitis in a patient with chronic myelomonocytic leukemia.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, University Hospital Leipzig, Germany.

Cutaneous granulomatous reaction patterns are inflammatory disorders with variable clinical and histological manifestations. We report on a patient with the rare case of palisaded neutrophilic and granulomatous dermatitis (PNGD). This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/jdv.15504DOI Listing
February 2019

A case of childhood-onset cutaneous mastocytosis with loss of wild-type KIT allele.

J Eur Acad Dermatol Venereol 2019 Feb 17. Epub 2019 Feb 17.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Childhood-onset cutaneous mastocytosis (CM) have been regarded as a clonal disease similar to adult-onset systemic mastocytosis since the discovery of somatic KIT mutations in pediatric patients. To our knowledge, all mutations previously detected in CM have been heterozygous. Here we report a case of pediatric CM in which only a KIT 502_503dupAY mutation, but not the wild-type allele, was detected. Read More

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http://dx.doi.org/10.1111/jdv.15501DOI Listing
February 2019

Nested case-control study investigating the diagnostic role of tissue eosinophilia in adverse cutaneous drug reactions.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Although tissue-eosinophilia has traditionally been considered diagnostically supportive of adverse cutaneous drug reactions (ACDRs), studies have suggested it is neither a sensitive nor a specific finding in drug eruptions (DEs).

Objectives: Determining whether skin-tissue eosinophilia is a reliable indicator of ACDR.

Methods: A nested case-control retrospective study conducted in a cohort of 170 patients at a single institution. Read More

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http://dx.doi.org/10.1111/jdv.15509DOI Listing
February 2019
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Clinicians vs. epidemiologists: Patch testing with methyldibromo glutaronitrile as a controversial issue.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Information Network of Departments of Dermatology (IVDK), University Medical Center, 37073, Göttingen, Germany.

The preservative methyldibromo glutaronitrile (MDBGN) (CAS 35691-65-7) is known since long as an important contact allergen mainly used in cosmetics (Review: [1]). MDBGN was banned EU-wide from being used in leave-on products in 2005, for rinse-off products in 2008, and further restricted for non-cosmetic (technical) applications in 2010. However, positive reactions in patch testing (PT) continued to occur. Read More

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http://dx.doi.org/10.1111/jdv.15505DOI Listing
February 2019

Ultrasonography for early detection of non-infectious necrotizing fasciitis secondary to cutaneous loxoscelism.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

A 50-year-old woman consulted to the emergency department for painful erythematous swelling on her forearm hours after a spider bite. The patient had spent the evening cleaning the outside of her home, located in the periphery of an urban area, next to a ravine, on the western Mediterranean Basin, when she identified a spider on the dorsum of her forearm. She described it as a light-brown coloured spider, with darker long legs, between 1 and 1,5 cm in size. Read More

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http://dx.doi.org/10.1111/jdv.15503DOI Listing
February 2019
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Comparison of efficacy of cold trypsinization versus warm trypsinization in preparation of autologous noncultured epidermal cell suspension for treatment of stable vitiligo.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

Surgical modalities are the mainstay of treatment for medically resistant vitiligo. Among various techniques, non-cultured epidermal cell suspension (NCES) has proven to be an effective and most accepted technique because of its advantage of treating large areas. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/jdv.15502DOI Listing
February 2019

Extended surgical safety margins and ulceration are associated with an improved prognosis in pleomorphic dermal sarcomas (PDS).

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Background: Pleomorphic dermal sarcomas (PDS) are frequent UV-induced sarcomas of the skin of intermediate grade malignant potential. Despite the fact that PDS have a noteworthy potential to recur (up to 28%) as well as to metastasize (up to 20%), there are no specific clinical guidelines with respect to follow-up these patients. Moreover, little is known about clinical, histological or molecular prognostic factors in PDS. Read More

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http://dx.doi.org/10.1111/jdv.15493DOI Listing
February 2019

Response to "Korean gender differences in hidradenitis suppurativa: nature or nurture?"

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

We thank R. Happle for his invaluable comments on our recent article regarding the prevalence of hidradenitis suppurativa (HS) in Korea. We agree with the opinion that the low prevalence of HS in Korean women may be due to the low number of female smokers in Korea. Read More

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http://dx.doi.org/10.1111/jdv.15500DOI Listing
February 2019

General health status in psoriasis patients, as assessed by the SF-12 questionnaire, is poorly associated with PASI.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Clinical Epidemiology Unit, IDI-IRCCS, Rome, Italy.

An important issue in medicine is how to measure the clinical severity of a disease. In psoriasis this is traditionally assessed using the Psoriasis Area and Severity Assessment (PASI). However, it is a concern that this measure does not really capture the burden that the disease has on patients. Read More

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http://dx.doi.org/10.1111/jdv.15495DOI Listing
February 2019

Food Protein-Induced Enterocolitis Syndrome in South Tyrol 2012-2016: a population based study.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

College of Health-Care Professions Claudiana, Bolzano/Bozen.

Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE-mediated food allergy to protein mainly in cow milk (CM) that typically presents in early infancy. Projectile and repetitive vomiting are the main clinical symptoms after 1-4 hours of trigger food ingestion. Rapid recognition and installment of a specific diet are important to avoid serious complications in affected children (see figure 1). Read More

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http://doi.wiley.com/10.1111/jdv.15510
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http://dx.doi.org/10.1111/jdv.15510DOI Listing
February 2019
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Psoriasis and skin pain: real-life effectiveness of calcipotriol plus betamethasone dipropionate in aerosol foam formulation.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Advanced Biomedical Sciences, University of Naples "Federico II", Italy.

Background/objective: Although 40% of psoriasis patients reported skin pain, this symptom is often underestimated. A new formula of calcipotriol plus betamethasone dipropionate (Cal/BD) has been recently approved for psoriasis treatment. Therefore, we aimed to evaluate the efficacy of Cal/BD aerosol foam on skin pain of patients with plaque psoriasis. Read More

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http://dx.doi.org/10.1111/jdv.15488DOI Listing
February 2019

Validation of the dermatology-specific proxy instrument the Infants and Toddlers Dermatology Quality of Life.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics number 1, National Medical University, Kiev, Ukraine.

Background: The first dermatology-specific proxy health related quality of life (HRQoL) instrument for children 0-4 years old with skin diseases, the Infants and Toddlers Dermatology Quality of Life (InToDermQoL), was recently developed. In order to avoid the problem of cross-cultural inequivalence focus groups work and pilot tests were organized simultaneously in all national centres of the project. The InToDermQoL showed good comprehensibility, clarity and acceptance. Read More

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http://dx.doi.org/10.1111/jdv.15496DOI Listing
February 2019

Alopecia neoplastica as a sign of visceral malignancies: a systematic review.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio, Emilia, Italy.

Alopecia neoplastica (AN) from visceral tumors is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumor. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. Read More

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http://dx.doi.org/10.1111/jdv.15498DOI Listing
February 2019
1 Read

The spectrum of benign dermal dendritic melanocytic proliferations.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Professor of Pathology, Department of Pathology, Istanbul Faculty of Medicine, Istanbul University.

Dermal melanocytoses (DMs) comprise a heterogeneous group of benign lesions, located on skin and mucous membranes, characterized by dendritic melanocytes in the dermis. Although they share common histopathological features, some variants may present only as bluish or gray patches, some only as papules/nodules/plaques and others may show combination of all of these lesions. Despite the fact that blue nevus is typically characterized with papulonodular lesions, its variants may show all of the aforementioned presentations. Read More

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http://doi.wiley.com/10.1111/jdv.15492
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http://dx.doi.org/10.1111/jdv.15492DOI Listing
February 2019
2 Reads

Korean gender differences in hidradenitis suppuratva: nature or nurture?

Authors:
R Happle

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Medical Center - University of Freiburg, Germany.

In a recent population-based study on hidradenitis suppurativa (HS) in Korea, Lee et al. found that the female to male ratio was 1:1.6. Read More

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http://dx.doi.org/10.1111/jdv.15507DOI Listing
February 2019

JAK inhibitors for alopecia areata: a systematic review and meta-analysis.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Liverpool Hospital, Sydney, Australia.

Background: There have been a number of case reports and small clinical trials reporting promising outcomes of JAK inhibitors tofacitinib, ruxolitinib, and baracitinib for alopecia areata (AA). The majority of the literature to date is based on small volume data, with a lack of definitive evidence or guidelines.

Objective: To determine the expected response of AA to JAK inhibitor therapy, and factors which influence response and recurrence rates. Read More

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http://dx.doi.org/10.1111/jdv.15489DOI Listing
February 2019
1 Read

Algorithms for ascertaining keratinocyte carcinomas using health insurance claims and prescription records.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Skin Science, University of British Columbia.

Skin cancer is the most common human malignancy with an ongoing continual increase in global incidence. Despite their high prevalence, keratinocyte carcinomas (KCs), namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are often excluded from population-based cancer registries. As there are over 3000 defined skin disease varieties that can be diagnosed, robust ascertainment methods are needed to capture KC cases for epidemiologic purposes. Read More

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http://dx.doi.org/10.1111/jdv.15490DOI Listing
February 2019

Commentary to 'Minimal clinically important difference (MCID) for work productivity and activity impairment (WPAI) questionnaire in psoriasis patients' by J.J. Wu et al.

Authors:
S M John

J Eur Acad Dermatol Venereol 2019 Feb;33(2):257-258

Department of Dermatology, Environmental Medicine, Health Theory, University of Osnabruck, Osnabrueck, Germany.

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http://dx.doi.org/10.1111/jdv.15418DOI Listing
February 2019

Pioneers in dermatology and venereology: an interview with Prof. Enno Christophers.

Authors:
E Christophers

J Eur Acad Dermatol Venereol 2019 Feb;33(2):260-262

Department of Dermatology, University of Kiel.

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http://dx.doi.org/10.1111/jdv.15436DOI Listing
February 2019

Long-term efficacy of ixekizumab in erythrodermic and generalized pustular psoriasis patients.

J Eur Acad Dermatol Venereol 2019 Feb;33(2):259

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/jdv.15416DOI Listing
February 2019

The course of chronic itch in hemodialysis patients: Results of a 4-year follow-up study of GEHIS (German Epidemiological Hemodialysis Itch Study).

J Eur Acad Dermatol Venereol 2019 Feb 11. Epub 2019 Feb 11.

Department of Clinical Social Medicine, Occupational and Environmental Dermatology, Ruprecht Karls University, University Hospital Heidelberg, Germany.

Background: Chronic itch (CI) is a frequent symptom in hemodialysis (HD) patients. Previous studies demonstrated great impairments of general well-being and health-related quality of life (HRQOL) as well as a higher mortality in those suffering from CI.

Objective: The German Epidemiological Hemodialysis Itch Study (GEHIS) is a representative cohort of HD patients in Germany. Read More

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http://dx.doi.org/10.1111/jdv.15483DOI Listing
February 2019

Galli-Galli disease successfully treated with alitretinoin.

J Eur Acad Dermatol Venereol 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands.

A 62-year-old man presented with a 10-year history of itchy erosions starting in the axillary region and inguinal area with progression to the trunk. He was previously diagnosed with Hailey-Hailey disease after clinicopathological correlation. Treatment with different combinations of topical and systemic antibiotics and corticosteroids showed no response. Read More

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http://dx.doi.org/10.1111/jdv.15485DOI Listing
February 2019

Iceberg sign as a dermoscopic clue of actinic keratosis neglecta.

J Eur Acad Dermatol Venereol 2019 Feb 11. Epub 2019 Feb 11.

Dermatology department, Hospital de la Santa Creu i Sant Pau.

Diagnosis of actinic keratosis (AK) is mainly clinical, but dermoscopy has proven useful in improving diagnostic accuracy. The patterns, structures and colors of AK can vary widely. Lesions may appear as white scales on a pseudo-network pattern, as keratotic plugs on a scaly white to yellow background, or as a strawberry pattern with white to yellow areas and keratotic follicular openings on an erythematous background. Read More

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http://doi.wiley.com/10.1111/jdv.15484
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http://dx.doi.org/10.1111/jdv.15484DOI Listing
February 2019
5 Reads

Epidermal aquaporin-3 downexpression in symmetrical acrokeratoderma.

J Eur Acad Dermatol Venereol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.

We read with interest the article by Chen et al that proposes a new term "pigmented carpotarsal hyperkeratosis" for "symmetrical acral keratoderma" or "symmetrical acrokeratoderma (SAK)". Aquaporin-3 (AQP3) is the most abundant aquaglyceroporin in human epidermis, and regulates skin hydration, keratinocyte migration and proliferation, wound healing, and tumorigenesis. Although skin hydration was decreased with incremental transepidermal water loss (TEWL) in SAK, AQP3 expression is unreported in SAK. Read More

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http://dx.doi.org/10.1111/jdv.15476DOI Listing
February 2019

Efficacy and safety of systemic treatments in psoriatic arthritis. A systematic review, meta-analysis and GRADE evaluation.

J Eur Acad Dermatol Venereol 2019 Feb 8. Epub 2019 Feb 8.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Department of Dermatology, Venerology und Allergy, Division of Evidence-Based Medicine (dEBM).

Twenty percent of patients with plaque psoriasis also have psoriatic arthritis - a disease affecting joints and entheses. Different treatment options exist but currently no succinct systematic overview exists. A systematic review of approved systemic treatments for psoriatic arthritis was conducted. Read More

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http://dx.doi.org/10.1111/jdv.15482DOI Listing
February 2019
2 Reads

"Trough (C0) and 2-hour post-dose (C2) cyclosporine monitoring in patients with moderate-to-severe psoriasis".

J Eur Acad Dermatol Venereol 2019 Feb 8. Epub 2019 Feb 8.

Dermatology department. Hospital, Universitario de La Princesa, Madrid, Spain.

Cyclosporine (CyA) has successfully been used to treat moderate-to-severe psoriasis. Therapeutic drug monitoring is an increasingly useful tool to optimize the management of immunosuppressant drugs. In transplantation grounds, dose management based on C2 (CyA blood levels 2 hours after the drug administration) has resulted in reduced incidence of acute rejection and treatment failure rates compared to dose management based on C0 (CyA blood levels immediately before drug administration). Read More

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http://dx.doi.org/10.1111/jdv.15481DOI Listing
February 2019
1 Read

Prostaglandins in androgenetic alopecia in 12 men and 4 female.

J Eur Acad Dermatol Venereol 2019 Feb 7. Epub 2019 Feb 7.

Universidad Autónoma de Nuevo León, Facultad de Medicina, Departamento de Dermatología, Monterrey, Mexico.

Androgenetic alopecia (AGA) is the most common form of hair loss in humans. Evidence suggests the participation of prostaglandins in the development of AGA. The aim of this study was to analyze the expression of the PTGDR2 (GPR44 receptor), PTGDS (Prostaglandin D2 synthase), and PTGES (Prostaglandin E synthase) transcripts in biopsies from balding scalp of hispanic patients with AGA and female androgenetic alopecia (FAGA). Read More

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http://dx.doi.org/10.1111/jdv.15479DOI Listing
February 2019
1 Read

Defining and measuring "eczema control": An international qualitative study to explore the views of those living with and treating atopic eczema.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.

Background: Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients' health and wellbeing. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that "long-term control of eczema" is measured in all clinical trials 3 months or longer in duration. However, little has been published on what eczema control means to those living with or treating atopic eczema. Read More

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http://dx.doi.org/10.1111/jdv.15475DOI Listing
February 2019
2 Reads

Stereophotogrammetric 3D photography is an accurate and precise planimetric method for the clinical visualization and quantification of HPV-induced skin lesions.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centre for Human Drug Research, Leiden, Netherlands.

Background: Quantification of HPV-induced skin lesions is essential for the clinical assessment of the course of disease and the response to treatment. However, clinical assessments that measure dimensions of lesions using a caliper, do not provide complete insight into 3D lesions and its inter-rater variability is often poor.

Objective: The aim of this study was to validate a stereophotogrammetric 3D camera system for the quantification of HPV-induced lesions. Read More

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http://dx.doi.org/10.1111/jdv.15474DOI Listing
February 2019

Mucous membrane pemphigoid of the oral lichen type: a retrospective analysis of 16 cases.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Inselspital - Bern University Hospital, CH-3010, Bern, Switzerland.

Mucous membrane pemphigoid (MMP) and oral lichen planus (OLP) may be difficult to distinguish. We describe the characteristics of a retrospective series of patients with MMP with isolated oral involvement who presented clinical features indistinguishable from OLP. Proper classification of these MMP cases critically depended on the performance of direct immunofluorescence (DIF) microscopy studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15473
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http://dx.doi.org/10.1111/jdv.15473DOI Listing
February 2019
4 Reads

Reply to Woltsche N. et al. Managing adverse effects by dose reduction during routine treatment of locally advanced basal cell carcinoma with the hedgehog inhibitor vismodegib: a single center experience.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

We read with great interest the article entitled "Managing adverse effects by dose reduction during routine treatment of locally advanced basal cell carcinoma (laBCC) with the hedgehog inhibitor vismodegib: a single center experience" recently published in your journal and we want to report also our experience regarding the effect of dose reduction of hedgehog inhibitor vismodegib treatment as a new therapeutic option in order to reduce the high frequency of adverse events and increase patients compliance. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/jdv.15469DOI Listing
February 2019

Innate immune response of human epidermal keratinocytes and dermal fibroblast to in vitro incubation of Trichophyton benhamiae DSM 6916.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Jena University Hospital, Jena, Germany.

Background: Superficial cutaneous infection caused by the zoophilic dermatophyte Trichophyton benhamiae is often associated with a highly inflammatory immune response. As non-professional immune cells, epidermal keratinocytes and dermal fibroblasts contribute to the first line of defence by producing pro-inflammatory cytokines and antimicrobial peptides (AMP).

Objective: Purpose of this study was to gain a deeper understanding of the pathogenesis and the fungal-host interaction as not much is known about the innate immune response of these cutaneous cells against T. Read More

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http://dx.doi.org/10.1111/jdv.15472DOI Listing
February 2019

Peritumoral clefting as a key feature in differentiating basal cell carcinoma from trichoblastoma through in-vivo reflectance confocal microscopy.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

Adnexal tumors represent one of the most troublesome differential diagnosis when dealing with skin lesions with clinical and dermoscopic criteria suggestive for basal cell carcinoma (BCC). Among these, benign follicular tumors, and in particular trichoblastoma and trichoepithelioma, deserve a special mention as BCC mimickers. These are benign tumors showing differentiation toward the outer follicular sheath. Read More

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http://dx.doi.org/10.1111/jdv.15467DOI Listing
February 2019
10 Reads

Allergic contact dermatitis to gold weight upper-eyelid implant.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Hospital Universitario, 12 de Octubre, I+12 Research Institute Universidad Complutense, Madrid, Spain.

Gold-weights are used for the correction of lagophthalmos associated with facial nerve injury since the 1960s. Complications associated with these are rare, being more frequent those associated with incorrect size and weight of the implant or infections processes. Non-infectious persistent inflammatory reactions, suggesting type IV hypersensitivity to gold, are poorly described in the literature. Read More

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http://dx.doi.org/10.1111/jdv.15470DOI Listing
February 2019
1 Read

Acquired linear hyperpigmentation of the lips - a new entity?

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Université Nice Côte d'Azur. Centre Hospitalier Universitaire Nice, Department of Dermatology. Nice, France.

we observed the occurrence of an acquired and long-lasting linear hyperpigmentation located only on the lips that does not correspond to any of previously described entity. We conducted a multicentric retrospective study from June 2016 to April 2018 to characterize the clinical presentation and to determine if it corresponds to a new entity. All the patients presenting with acquired hyperpigmentation of the lips were included. Read More

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http://dx.doi.org/10.1111/jdv.15471DOI Listing
February 2019

Declining Recommended Surgery in Primary Cutaneous Melanoma: An Analysis of Risk Factors and Survival.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

With over 1.2 million Americans currently living with primary cutaneous melanoma and an estimated 85,000 cases new cases diagnosed in 2017, melanoma represents one of the most commonly diagnosed tumors. The standard of care often involves surgical treatment. Read More

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http://dx.doi.org/10.1111/jdv.15468DOI Listing
February 2019
1 Read

Pigmented aqua-exacerbated symmetrical acral hyperkeratosis (PASAH).

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

We congratulate Chen et al for summarizing 'symmetrical acral keratoderma (SAK)' in an exhaustive review. We had recently reported the first non-Chinese series of 5 patients of SAK from India. As observed by Chen and colleagues, and also reported by other authors, SAK rarely involves the palms and soles, but commonly affects the dorsal hands and feet, flexural surface of wrists and forearms and might also extend to involve the elbows and knees. Read More

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http://dx.doi.org/10.1111/jdv.15466DOI Listing
February 2019

CD103 negative memory T cells may play important roles in making regulatory T cell-enriched environments in skin tumors.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Human skin contains resident memory T cells (T ) and central memory T cells (T ) . T are characterized by CD69 expression and can be divided into 2 subpopulations: CD103 T and CD103 T . Although both T and T showed antitumor efficacy in a mouse model , little is known about their role in human skin cancer. Read More

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http://dx.doi.org/10.1111/jdv.15478DOI Listing
February 2019

Alopecic patches of the scalp: a variant of primary cutaneous follicle center B-cell lymphoma reported in a series of 14 cases.

J Eur Acad Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

INSERM, UMR976, Centre de Recherche sur la Peau.

Primary cutaneous follicle center lymphoma (PCFCL) is the most frequent primary cutaneous B-cell lymphoma. It presents usually with erythematous papules, plaques and tumors that predominate on the head, neck and upper trunk. The evolution is indolent but relapses are frequent. Read More

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http://dx.doi.org/10.1111/jdv.15477DOI Listing
February 2019
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Comment on Dai R. et al.: The effect of milk consumption on acne: a meta-analysis of observational studies.

J Eur Acad Dermatol Venereol 2019 Feb 3. Epub 2019 Feb 3.

Dermalife Centre, Bucharest-Ploiesti Road no 10, Bucharest, Romania.

We have read with interest the article on milk implication in acne pathogenesis and we would like to congratulate the authors for creating the first meta-analysis on this subject (1). Acne is a cutaneous disease with major implications for both adolescent and adult patients and each step towards the establishment of a complete, complex and individually adapted management plan (including dietary interventions) is of most importance. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/jdv.15465DOI Listing
February 2019

Variable response to low-dose naltrexone in patients with Darier disease: a case series.

J Eur Acad Dermatol Venereol 2019 Feb 3. Epub 2019 Feb 3.

Dermatology of Technical, University of Munich.

Background: Darier disease is a rare autosomal-dominant genodermatosis with a loss of function of a Ca -ATPase pump (SERCA2-pump). Clinically, the disease is characterized by red-brown keratotic papules mainly in seborrheic areas and has only limited and unsatisfactory treatment options. Previously, low-dose naltrexone was described as a successful treatment option in Hailey-Hailey-disease, a genodermatosis with a genetic mutation coding for a similar loss of function of a Ca -ATPase pump (hSPCA1-pump). Read More

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http://doi.wiley.com/10.1111/jdv.15457
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http://dx.doi.org/10.1111/jdv.15457DOI Listing
February 2019
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Understanding roofers' sun protection behaviour: A qualitative study.

J Eur Acad Dermatol Venereol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.

The incidence of keratinocyte carcinoma (KC), which includes squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and actinic keratosis (AK), has steadily increased in the last few decades; moreover, KC is the most common malignancy in Caucasians worldwide. As exposure to solar ultraviolet radiation (UVR) is the main risk factor for KC, outdoor workers bear a high risk for KC. Therefore, SCC and AK were officially recognised as occupational diseases in Germany in 2015. Read More

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http://dx.doi.org/10.1111/jdv.15460DOI Listing
February 2019
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Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis.

J Eur Acad Dermatol Venereol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstr. 9-11, 80337, Munich, Germany.

Background: Photodynamic therapy (PDT) is a highly effective treatment option for patients with actinic keratoses (AK). However, efficacy can be reduced by insufficient illumination or hyperkeratotic nature of lesions.

Objectives: To investigate if PDT combined with a topical intervention is superior to monotherapy in terms of efficacy and tolerability. Read More

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http://dx.doi.org/10.1111/jdv.15459DOI Listing
February 2019

MULTISYSTEM NON-ARTHROPATHIC RETICULOHISTIOCYTOSIS Problems and pitfalls in the differential diagnosis of multisystem non-Langerhans cell histiocytoses.

J Eur Acad Dermatol Venereol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Histiocytoses are rare proliferative disorders of the mononuclear-phagocyte system. Within non-Langerhans-cell histiocytoses (NLCH), multisystem (MS) cases potentially constitute a subset at high risk of complications and progression. The current 2016 revised classification subdivides histiocytoses in 5 groups, based on highly heterogeneous criteria. Read More

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http://dx.doi.org/10.1111/jdv.15461DOI Listing
February 2019
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Atenolol treatment for severe infantile hemangiomas: comparison with a propranolol group of our centre.

J Eur Acad Dermatol Venereol 2019 Feb 1. Epub 2019 Feb 1.

First Department of Pediatrics, University of Athens, Aghia Sofia" Children's Hospital, Athens, Greece.

Infantile hemangiomas (IHs) are common benign vascular tumors of infancy . Although most of them tend to resolve spontaneously, it is estimated that approximately 10% require intervention due to complications or disfigurements . The discovery of the inhibitory effects of propranolol, a non selective b blocker, during the prolipherative phase of IHs was an important development in the treatment of IHs, though its mechanism of action is not yet clear . Read More

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http://dx.doi.org/10.1111/jdv.15464DOI Listing
February 2019

The influence of adalimumab on the expression profile of mRNAs and miRNAs related to the IL-12 and IL- 23 signal paths.

J Eur Acad Dermatol Venereol 2019 Feb 1. Epub 2019 Feb 1.

Department of Molecular Biology, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice.

This study was financed by the Medical University of Silesia in Katowice/Poland on the basis of decision no. KNW-1-029/N/6/O. This research was supported in part by PLGrid Infrastructure. Read More

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http://dx.doi.org/10.1111/jdv.15463DOI Listing
February 2019