7,917 results match your criteria Journal of the European Academy of Dermatology and Venereology[Journal]


Frequency of isolated cutaneous involvement in adult mastocytosis: a cohort study.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

Reference Centre for Mastocytosis (CEREMAST) Toulouse, Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.

Background: Mastocytosis is characterized by the accumulation/proliferation of abnormal mast cells. The frequency of isolated cutaneous involvement in adults with mastocytosis has not been fully determined. The main objective of our study was to assess the frequency of isolated cutaneous mastocytosis (CM) in adults with mastocytosis skin lesions. Read More

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http://dx.doi.org/10.1111/jdv.15638DOI Listing

Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in psoriasis patients treated up to 5 years.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

Background: Secukinumab is a fully human monoclonal antibody that selectively neutralizes IL-17A, a key cytokine involved in psoriasis (PsO) and psoriatic arthritis (PsA) development, and has shown rapid and long lasting efficacy and safety in the complete spectrum of psoriasis manifestations. Monoclonal antibody therapies may be associated with the production of treatment-emergent anti-drug antibodies (TE-ADA) that can affect drug pharmacokinetics, diminish clinical responses via inhibition of target binding, or cause hypersensitivity reactions. Secukinumab exhibited minimal immunogenicity up to 52 weeks in patients with moderate-to-severe plaque psoriasis, as evidenced by TE-ADA in <1% patients. Read More

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http://dx.doi.org/10.1111/jdv.15637DOI Listing

Characteristics, risk factors, and treatment reality in livedoid vasculopathy - a multi-centre analysis.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

University Hospital of Muenster, Dept. of Dermatology, Von Esmarch Str. 58, 48149, Muenster, Germany.

Background: Livedoid vasculopathy is a rare cutaneous thrombotic disease. It is characterized by occlusion of dermal vessels resulting in livedo racemosa, ulceration and atrophie blanche. Clear guidelines for diagnosis and treatment are missing. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15639
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http://dx.doi.org/10.1111/jdv.15639DOI Listing
April 2019
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Dermatoscopy in leprosy and its correlation with clinical spectrum and histopathology: A prospective observational study.

J Eur Acad Dermatol Venereol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Venereology, Leprology, Post Graduate Institute of Medical Education and Research, Sector 12Chandigarh, India.

Background: Leprosy is a chronic granulomatous infection with varied clinical presentations. In this study, we aimed to describe the dermatoscopic features of the entire spectrum of leprosy and to correlate with clinical and histopathological findings.

Methodology: This was a prospective observational study of treatment naïve leprosy patients over a period of 1 year. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15635
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http://dx.doi.org/10.1111/jdv.15635DOI Listing
April 2019
1 Read
2.826 Impact Factor

Sarcoidosis occurring during BRAF/MEK inhibitors is associated with paradoxical ERK activation in Erdheim-Chester patients.

J Eur Acad Dermatol Venereol 2019 Apr 19. Epub 2019 Apr 19.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares, Lupus Systémique, Syndrome des Anticorps Antiphospholipides et Histiocytoses, Paris, 75013, France.

Almost 70% of patients with Erdheim-Chester disease (ECD), a rare non-Langerhans cell histiocytosis, harbor the somatic V600E mutation of the BRAF gene. BRAF and MEK inhibitors are dramatically efficacious for treating ECD, particularly in cases of life-threatening manifestations [1]. Sarcoidosis-like disorders have been described during treatments with targeted therapies for cancers [2]. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15636
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http://dx.doi.org/10.1111/jdv.15636DOI Listing
April 2019
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Atopic Eczema: Burden of disease and individual suffering - Results from a large EU-Study in adults.

J Eur Acad Dermatol Venereol 2019 Apr 19. Epub 2019 Apr 19.

European Federation of Allergy and Airway Diseases Patient's Associations, Brussels, Belgium.

Background: Atopic eczema (AE, atopic dermatitis) is one the most common non-communicable inflammatory skin diseases affecting 1-5% of the adult population in Europe with marked impairment in quality of life. In spite of great progress in understanding the pathophysiology of disturbed skin barrier and immune deviation, AE still represents a problem in daily clinical practice. Furthermore, the true impact of AE on individual suffering is often not recognized. Read More

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http://dx.doi.org/10.1111/jdv.15634DOI Listing

Efficacy of ixekizumab in patients with resistance or incomplete response to secukinumab.

J Eur Acad Dermatol Venereol 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, Toulouse University, Hôpital Larrey, Toulouse, France.

Clinical studies have the shown rapid efficacy biological agents targeting anti-IL17 in patients with moderate to severe plaque psoriasis. However, preliminary data from the Danish registry DERMBIO showed a significant loss of efficacy with secukinumab. This was a retrospective study of 14 patients treated with secukinumab for moderate-to-severe psoriasis who had an incomplete initial response or who experienced a loss of efficacy with secukinumab and who were subsequently treated with ixekizumab. Read More

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http://dx.doi.org/10.1111/jdv.15630DOI Listing

Absence of thick, nodular melanomas during long-term surveillance with total body photography and digital dermatoscopy.

J Eur Acad Dermatol Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Statistics and Data Science, Faculty of Statistical Studies, Universidad Complutense, Madrid, Spain.

We have read with great interest the article by Gassenmaier et al. stating that regular total body skin examination in patients with a first primary melanoma was associated with a reduction in thickness in subsequent melanomas. From a theoretical point of view, de novo fast-growing melanomas with rapid vertical growth from the outset, leading to thick nodular melanomas, would be difficult to avoid despite regular follow-up. Read More

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http://dx.doi.org/10.1111/jdv.15631DOI Listing
April 2019
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1-CD30 expression in cutaneous lesions of systemic mastocytosis: clinical, biological and histopathological analysis of 27 patients.

J Eur Acad Dermatol Venereol 2019 Apr 16. Epub 2019 Apr 16.

Sorbonne Université, UPMC Université Paris 06, Unité Fonctionnelle de Dermatologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.

Mastocytosis is a composite group of heterogeneous diseases defined by the accumulation of abnormal mast cells (MCs) in various tissues. Cutaneous and bone marrow tissues are the most frequently infiltrated in adult patients with systemic mastocytosis (SM) (1) The CD30 (KI-1 antigen) receptor, belongings to the tumor necrosis factor receptor family, may have a role in mastocytosis. CD30 expression in MCs cytoplasm was reported in 2011 by Sotlar K et al. Read More

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http://dx.doi.org/10.1111/jdv.15633DOI Listing
April 2019
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Ibrutinib-associated palmo-plantar fissures in a patient with Chronic Lymphocytic Leukaemia: a novel cutaneous adverse event.

J Eur Acad Dermatol Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Catholic University of the Sacred Heart, Fondazione Policlinico A. Gemelli - IRCCS, Rome.

Chronic lymphocytic leukaemia (CLL) is the most common adult-onset lymphoproliferative disorder, characterised by the accumulation of monoclonal neoplastic B lymphocytes. Patients are usually asymptomatic and diagnosis is often incidental. Poor prognosis is associated to cytogenetic alterations such as TP53 mutation or deletion(17p), and such patients show no response or rapid disease progression with standard rituximab-based combination chemotherapy. Read More

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http://dx.doi.org/10.1111/jdv.15632DOI Listing
April 2019
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Phenotypic analysis of atopic dermatitis in children aged 1-12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence.

J Eur Acad Dermatol Venereol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Dermatology, Shanghai Jiaotong University School of Medicine.

Background: Atopic dermatitis (AD) is the most common skin disorder in infancy. However, the diagnosis and definite significance of infantile AD remains a debated issue.

Objective: To analyze the phenotypes of AD in infancy, to establish diagnostic criteria, and to estimate the prevalence of this condition in China. Read More

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http://dx.doi.org/10.1111/jdv.15618DOI Listing
April 2019
2 Reads

Characterization of perianal fistulas in patients with hidradenitis suppurativa.

J Eur Acad Dermatol Venereol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease characterized by recurring abscesses, nodules and draining fistulas in the intertriginous regions of the body. Anogenital involvement is present in 18.8% of HS patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15629
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http://dx.doi.org/10.1111/jdv.15629DOI Listing
April 2019
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Pioneers in Dermatology and Venereology: An Interview with Prof. Robin Marks.

Authors:
R Marks

J Eur Acad Dermatol Venereol 2019 Apr 15. Epub 2019 Apr 15.

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http://dx.doi.org/10.1111/jdv.15607DOI Listing

Annular elastolytic giant cell granuloma following Herpes Zoster infection.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Institute of Dermatology, Catholic University - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

A 66-year-old psoriatic patient was examined for the occurrence of annular lesions with a dermatomeric distribution on the trunk since four weeks. The patient claimed that the lesions appeared at the site of a previous Herpes Zoster virus (HZV) infection, which had been treated with intravenous acyclovir three months earlier. At the time of the annular eruption, the patient was under treatment with apremilast (30 mg twice daily) for moderate-to-severe psoriasis, and systemic mycophenolate mofetil (1,250 gr daily), methylprednisolone (4 mg daily) and tacrolimus (1 mg daily) due to liver transplantation four years earlier for a cryptogenic liver cirrhosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15627
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http://dx.doi.org/10.1111/jdv.15627DOI Listing
April 2019
7 Reads

Climate change and skin cancer.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/jdv.15622DOI Listing

Integrating the concept of field cancerization in the classification and risk assessment of cutaneous squamous cell carcinoma: proposal for a new classification and terminology of keratinocyte skin cancer.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

The term keratinocyte skin cancer (KC) stands as an umbrella for different stages within the progression of cutaneous squamous cell carcinoma (cSCC). Its earliest form is named actinic keratosis (AK), while for the in-situ form different synonyms, namely intraepidermal carcinoma (IEC), Bowen's Diseases (BD) and cutaneous squamous cell carcinoma in situ [cSCC(Tis)] or intraepithelial squamous cell carcinoma (iSCC) are used. Instead, cSCC is histopathologically classified into well, moderately and poorly differentiated subtypes. Read More

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http://dx.doi.org/10.1111/jdv.15624DOI Listing
April 2019
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Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Glomus tumors are painful, benign perivascular neoplasms of the glomus body affecting the nail apparatus. Although diagnosis can be made clinically using Love's and Hildreth's tests, imaging is required to distinguish glomus tumors from other subungual vascular lesions. Clinical diagnosis is complicated when the nail has no visible abnormalities. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15626
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http://dx.doi.org/10.1111/jdv.15626DOI Listing
April 2019
3 Reads

Successful response of genital psoriasis to ixekizumab: report of 6 cases.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Consorci Hospital General Universitari de Valencia.

Psoriasis is a chronic inflammatory disease affecting up to 2-3% of the population worldwide . Genital psoriasis (GenPs) is a frequent, debilitating, stigmatizing and difficult-to-treat manifestation of plaque psoriasis. Literature is scarce on controlled trials dedicated to the management and effective treatment of this special localization . Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15623
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http://dx.doi.org/10.1111/jdv.15623DOI Listing
April 2019
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Migraine is not the most common comorbidity in hidradenitis suppurativa patients.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of dermatology, allergology and venereology, Helsinki University Central Hospital, Helsinki, Finland.

Migraine is the most common primary headache syndrome worldwide, affecting approximately 12% of the Caucasian population [1]. Migraine has been associated with various cardiovascular [2] and psychiatric co-morbidities [3], more recently inflammatory disorders such as psoriasis [4] and inflammatory bowel disease [5]. As hidradenitis suppurativa (HS) shares common comorbidity risks, we sought to investigate the possible link between migraine and HS. Read More

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http://dx.doi.org/10.1111/jdv.15625DOI Listing
April 2019
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Efficacy of sirolimus in the treatment of microcystic lymphatic malformation of the tongue.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Farhat Hached University Hospital, Sousse, Tunisia.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15628
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http://dx.doi.org/10.1111/jdv.15628DOI Listing
April 2019
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Malignant proliferating trichilemmal tumour arising on a trichilemmal cyst with dermoscopic and histopathologic findings.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Ankara University, Faculty of Medicine, Department of Pathology, Ankara, Turkey.

Cutaneous adnexial tumours derived from the outer root sheath of hair follicles are trichilemmal tumours or pilar cysts. These tumours show trichilemmal keratinization as formation of a dense keratin layer without interposition of the granular cell layer. Trichilemmal cysts can form rapidly multiplying trichilemmal tumors, also called proliferating trichilemmal tumour (PTT) or cyst. Read More

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http://dx.doi.org/10.1111/jdv.15621DOI Listing
April 2019
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Dermoscopy use in UK primary care: a survey of GPs with a special interest in dermatology.

J Eur Acad Dermatol Venereol 2019 Apr 12. Epub 2019 Apr 12.

The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, UK.

Background: Melanoma accounts for 90% of skin cancer mortality and typically presents in primary care, where it can be challenging to distinguish from benign lesions. Dermoscopy is a tool for skin visualisation that is routinely used for melanoma diagnosis in secondary care. However, the role of dermoscopy in primary care remains unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15614
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http://dx.doi.org/10.1111/jdv.15614DOI Listing
April 2019
5 Reads

Increased incidence of ischaemic heart disease and cerebrovascular disease in psoriasis patients with depression: A nationwide retrospective cohort study.

J Eur Acad Dermatol Venereol 2019 Apr 12. Epub 2019 Apr 12.

Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Psoriasis is known to confer a higher risk of cardiovascular and cerebrovascular diseases. However, very few studies have investigated whether the development of depression in psoriasis patients may further increase this vascular risk.

Objective: We investigated the risk of ischaemic heart disease and cerebrovascular disease in Taiwanese psoriasis patients with and without depression. Read More

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http://dx.doi.org/10.1111/jdv.15616DOI Listing
April 2019
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Validation and psychometric evaluation of a brief screening questionnaire for psychological distress in patients with psoriasis.

J Eur Acad Dermatol Venereol 2019 Apr 12. Epub 2019 Apr 12.

St. Vincent's University Hospital.

Background: Patients with psoriasis are at risk of a comorbid diagnosis of depression and/or anxiety. It is therefore essential for dermatologists to have valid and effective instruments that can screen and monitor depression and anxiety symptoms in psoriasis patients.

Objective: The aim of this study was to validate the Mental Health Inventory (MHI-5) as a brief measure that can be used to evaluate psychological distress related to anxiety and depression in psoriasis patients. Read More

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http://dx.doi.org/10.1111/jdv.15612DOI Listing
April 2019
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External validation and comparison of four confocal microscopic scores for melanoma diagnosis on a retrospective series of highly suspicious melanocytic lesions.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Italy.

Background: In-vivo reflectance confocal microscopy significantly improves melanoma diagnosis as compared to clinical/dermoscopic examination alone. Several confocal criteria have been described allowing to differentiate melanoma from nevi; by combining different criteria three pure confocal scores (Pellacani 2005, Segura 2009 and Pellacani 2012) and one mixed dermoscopic/confocal score (Borsari 2018) were constructed.

Objective: Our aim was to externally validate and compare the performance of these confocal scores. Read More

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http://dx.doi.org/10.1111/jdv.15617DOI Listing
April 2019
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Distinguishing melanocytic nevi from melanomas using static and dynamic infrared thermal imaging.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

LABIOMEP, INEGI-LAETA, Faculdade de Engenharia, Universidade do Porto.

Background: The incidence rates of melanoma have risen to worrying levels over the last decade. Delayed diagnosis, due to faults on the detection stage, indicate the necessity of new aiding diagnosis techniques. Since metabolic activity is highly connected to neoplasia formation, a detection technique that focus its results on vascular responses, as IRT, seems to be a viable option. Read More

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http://dx.doi.org/10.1111/jdv.15611DOI Listing
April 2019
1 Read

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

CentroDerm GmbH, Heinz-Fangman-Straße 57, Wuppertal, Germany.

Background: Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).

Objective: To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive SCCs.

Methods: All samples were histologically evaluated. Read More

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http://dx.doi.org/10.1111/jdv.15615DOI Listing
April 2019
2 Reads

Position statement for the diagnosis and management of anogenital warts.

J Eur Acad Dermatol Venereol 2019 Apr 10. Epub 2019 Apr 10.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Anogenital warts (AGW) can cause economic burden on healthcare systems and are associated with emotional, psychological and physical issues.

Objective: To provide guidance to physicians on the diagnosis and management of AGW.

Methods: Fourteen global experts on AGW developed guidance on the diagnosis and management of AGW in an effort to unify international recommendations. Read More

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http://dx.doi.org/10.1111/jdv.15570DOI Listing
April 2019
2 Reads

2018 European guideline on the organization of a consultation for sexually transmitted infections.

J Eur Acad Dermatol Venereol 2019 Apr 10. Epub 2019 Apr 10.

University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15577
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http://dx.doi.org/10.1111/jdv.15577DOI Listing
April 2019
1 Read

Quality of life measurement in skin cancer patients: literature review and position paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer.

J Eur Acad Dermatol Venereol 2019 May 8;33(5):816-827. Epub 2019 Apr 8.

Department of Dermatology and Wound Healing, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information about the impact of SC on QoL. Generic, dermatology-specific, cancer-specific, SC-specific, facial SC-specific, NMSC-specific, basal cell carcinoma-specific and melanoma-specific QoL questionnaires have been used to assess HRQoL in SC patients. Read More

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http://dx.doi.org/10.1111/jdv.15487DOI Listing
May 2019
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Treatment of atopic dermatitis with dupilumab: experience from a tertiary referral center.

J Eur Acad Dermatol Venereol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermato-venereology, Bispebjerg Hospital, University of Copenhagen, Denmark.

Background: Management of moderate-to severe atopic dermatitis (AD) frequently requires treatment with systemic therapies. Dupilumab is the first biological agent approved for treatment of moderate-to severe AD. Although promising results have appeared in clinical trials, real-life data on efficacy and safety are lacking. Read More

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http://dx.doi.org/10.1111/jdv.15609DOI Listing
April 2019
1 Read

Position statement: LEPROSY: Diagnosis, treatment and follow-up.

J Eur Acad Dermatol Venereol 2019 Apr 3. Epub 2019 Apr 3.

Department of Dermatovenereology, Ayder Referral Hospital Mekelle University, Mekelle, Tigray, Ethiopia.

Background: Leprosy or Hansen's disease is a chronic infection caused by Mycobacterium leprae (M. leprae) or Mycobacterium lepromatosis (M. lepromatosis). Read More

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http://dx.doi.org/10.1111/jdv.15569DOI Listing
April 2019
3 Reads

Topical steroids for the treatment of retronychia.

J Eur Acad Dermatol Venereol 2019 Apr 1. Epub 2019 Apr 1.

Hôpitaux universitaires Saint Pierre & Brugmann, Hôpital universitaire des enfants Reine-Fabiola, Université Libre de Bruxelles, Belgium.

The term retronychia originated in 1999 (1) and a first series of cases was published in 2008. (2) A disturbance in the continuous longitudinal nail growth (3) leads to an upward and backward nail displacement with posterior embedding. Several nail plates pile up beneath the proximal nail fold (PNF) generating paronychia and granulation tissue. Read More

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http://dx.doi.org/10.1111/jdv.15603DOI Listing
April 2019
1 Read

Another source of allergic contact dermatitis to isothiazolinones in children-urgent call for regulation.

J Eur Acad Dermatol Venereol 2019 Mar 29. Epub 2019 Mar 29.

Dermatology Department, Coimbra University Hospital, Coimbra, Portugal.

Allergic contact dermatitis (ACD) from isothiazolinones is frequent and following an epidemic sensitization their use in leave-on products in Europe was forbidden and restricted that in rinse-off cosmetics, with a consequent decrease in the frequency of new cases in Europe, but still not evident in Portugal. Although more common in adults, methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are also prevalent paediatric contact sensitizers. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/jdv.15602DOI Listing
March 2019
1 Read

Pioneers in dermatology and venereology: an interview with Prof. Andrew Finlay.

Authors:
A Y Finlay

J Eur Acad Dermatol Venereol 2019 Apr;33(4):633-636

Cardiff University School of Medicine, Cardiff, UK.

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http://dx.doi.org/10.1111/jdv.15550DOI Listing

Severity, heterogeneity and systemic inflammation in psoriasis.

J Eur Acad Dermatol Venereol 2019 Apr;33(4):643-647

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Psoriasis may express as active severe disease or as mild stable disease. In particular, patients with active severe disease present systemic involvement, including comorbidities and increased values of parameters reflecting an active state of innate immunity. In contrast, patients with mild stable disease show a dominancy of acquired immunity. Read More

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http://dx.doi.org/10.1111/jdv.15339DOI Listing

A two-step immunoblot assay for serological diagnosis of anti-laminin γ-1 pemphigoid.

Authors:
J Yamagami M Amagai

J Eur Acad Dermatol Venereol 2019 Apr;33(4):632

Department of Dermatology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdv.15555DOI Listing

The skin is close to our heart.

Authors:
J Ring

J Eur Acad Dermatol Venereol 2019 Apr;33(4):627-628

Department Dermatology and Allergy Biederstein, Technical University, Munich, Munich, Germany.

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http://dx.doi.org/10.1111/jdv.15549DOI Listing

Evaluation of cutaneous adverse events of encorafenib and binimetinb: COMMENT on article by Graf et al.

Authors:
E Livingstone

J Eur Acad Dermatol Venereol 2019 Apr;33(4):630-631

Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1111/jdv.15527DOI Listing

Taking daylight-PDT home.

Authors:
E Ramelyte L Imhof

J Eur Acad Dermatol Venereol 2019 Apr;33(4):629

Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/jdv.15535DOI Listing

Laser therapy for onychomycosis in patients with diabetes at risk for foot ulcers: A randomised, quadruple-blind, sham controlled trial (LASER-1).

J Eur Acad Dermatol Venereol 2019 Mar 28. Epub 2019 Mar 28.

Medical Research Group Langerhans, Gerard Doustraat 36, 7731 MX, Ommen, the Netherlands.

Backgrounds: Patients with diabetes mellitus are at high risk for onychomycosis, which is related to development of foot ulcers.

Objective: The aim of this study was to evaluate the safety and efficacy of the treatment of onychomycosis with local laser therapy.

Methods: In a single-centre, randomised (1:1), quadruple blind, sham-controlled trial, patients with diabetes mellitus, at risk for developing diabetic foot ulcers (Sims classification score 1,2) and a clinical suspicion on onychomycosis were randomised to either 4 sessions neodymium- doped yttrium aluminium garnet (Nd-YAG) 1064nM laser or sham treatment. Read More

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http://dx.doi.org/10.1111/jdv.15601DOI Listing
March 2019
1 Read

Rapid onset of action of calcipotriol/betamethasone dipropionate cutaneous foam in psoriasis, even in patients with more severe disease.

J Eur Acad Dermatol Venereol 2019 Mar 27. Epub 2019 Mar 27.

Dermatology Private Practice, Tremelo, Belgium.

Background: The effectiveness of topical therapies in psoriasis is dependent on, amongst other factors, patient adherence. Together with treatment effectiveness and reduction of symptoms, speed of onset and health-related quality of life (HRQoL) are important influencers of adherence.

Methods: This pooled analysis of three Phase II/III trials evaluated the efficacy of topical fixed-dose combination calcipotriol 50 μg/g plus betamethasone dipropionate 0. Read More

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http://dx.doi.org/10.1111/jdv.15398DOI Listing

Port wine stain treatment outcomes have not improved over the past three decades.

J Eur Acad Dermatol Venereol 2019 Mar 25. Epub 2019 Mar 25.

Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, China.

Background: Since the early '80s, the pulsed dye laser has been the standard treatment tool for non-invasive port wine stain (PWS) removal. In the last three decades, a considerable amount of research has been conducted to improve clinical outcomes, given that a fraction of PWS patients proved recalcitrant to laser treatment. Whether this research actually led to increased therapeutic efficacy has not been systematically investigated. Read More

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http://dx.doi.org/10.1111/jdv.15599DOI Listing
March 2019
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The microbiome of tunnels in hidradenitis suppurativa patients.

J Eur Acad Dermatol Venereol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Zealand University Hospital, Roskilde, Health Sciences Faculty, University of Copenhagen, Denmark.

Background: Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. Recent Next Generation Sequencing (NGS) studies suggest genera such as Prevotella spp., Peptoniphilus spp. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15597
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http://dx.doi.org/10.1111/jdv.15597DOI Listing
March 2019
7 Reads

Spatial clustering, social vulnerability and risk of leprosy in an endemic area in Northeast Brazil: an ecological study.

J Eur Acad Dermatol Venereol 2019 Mar 23. Epub 2019 Mar 23.

Centre for Epidemiology and Public Health, Federal University of Alagoas, Arapiraca, Brazil.

Background: Despite the global decline in the detection of leprosy cases, its incidence has remains unchanged in certain settings and requires the determination of the factors linked to its persistence. We examined the spatial and space-time distribution of leprosy and the influence of social vulnerability on the occurrence of the disease in an endemic area of Northeast Brazil.

Methods: We performed an ecological study of all leprosy cases reported by Sergipe state, Northeast Brazil from 2001 to 2015, to examine the association of the social vulnerability index and the prevalence and persistence of leprosy among the State's municipalities. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15596
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http://dx.doi.org/10.1111/jdv.15596DOI Listing
March 2019
9 Reads

A case-control study of risk factors associated with Zoon balanitis in men.

J Eur Acad Dermatol Venereol 2019 Mar 23. Epub 2019 Mar 23.

Urology Department, University of Padova, Padova, Italy.

Background: Zoon balanitis (ZB) is a chronic inflammatory benign mucositis. Its etiopathogenesis still remains hypothetical and speculative.

Objectives: To determine risk factors associated with genital ZB in men. Read More

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http://dx.doi.org/10.1111/jdv.15594DOI Listing

Association of sensitive skin with sensitive corneas and sensitive eyelids.

J Eur Acad Dermatol Venereol 2019 Mar 23. Epub 2019 Mar 23.

EMMA, Fontenay-sous-Bois, France.

Background: Sensitive scalp or irritable bowel syndrome has been previously shown to be associated with sensitive skin. We wondered whether sensitive eyelids and sensitive eyes could also be associated with sensitive skin.

Methods: A cross-sectional epidemiological study was carried out on a representative sample of French people, according to the quota method, using a questionnaire. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15595
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http://dx.doi.org/10.1111/jdv.15595DOI Listing
March 2019
5 Reads

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Authors:
W Chen G Plewig

J Eur Acad Dermatol Venereol 2019 Mar 23. Epub 2019 Mar 23.

Department of Dermatology and Allergy, Ludwig-Maximilian-University of Munich, Munich, Germany.

Since its first description as ulcus vulvae acutum by Benjamin Lipschütz in 1912, the etiopathogenesis of this peculiar genital ulcer remains incompletely understood. In his original description, two different types of genital ulcers were observed and proposed, which were not precisely defined and distinguished in most subsequent reports. The first type is characterized by acute excruciating genital ulcers of first-time onset with self-limited non-recurrent course in association with gravely symptomatic systemic infections, in which a primary Epstein-Barr virus (EBV) infection is later identified to be probably the most common aetiology. Read More

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http://dx.doi.org/10.1111/jdv.15598DOI Listing

Response from the CLOTHES Trial team.

Authors:
K S Thomas

J Eur Acad Dermatol Venereol 2019 Mar 21. Epub 2019 Mar 21.

Centre of Evidence Based Dermatology, University of Nottingham, UK.

We would like to respond to the recent letter by Wüthrich and colleagues.[1]. As Wüthrich et al. Read More

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http://dx.doi.org/10.1111/jdv.15587DOI Listing

An art-based visual literacy training course to enhance clinical skills in dermatology trainees.

J Eur Acad Dermatol Venereol 2019 Mar 21. Epub 2019 Mar 21.

Centre for Dermatology Research, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/jdv.15588DOI Listing