889 results match your criteria Journal of the Association for Research in Otolaryngology [Journal]


Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice.

J Assoc Res Otolaryngol 2019 Apr 18. Epub 2019 Apr 18.

Institute of Human Genetics, Jena University Hospital, Friedrich Schiller Universität, Am Klinikum 1, 07747, Jena, Germany.

The unique composition of the endolymph with a high extracellular K concentration is essential for sensory transduction in the inner ear. It is secreted by a specialized epithelium, the stria vascularis, that is connected to the fibrocyte meshwork of the spiral ligament in the lateral wall of the cochlea via gap junctions. In this study, we show that in mice the expression of the bicarbonate transporter Slc4a10/Ncbe/Nbcn2 in spiral ligament fibrocytes starts shortly before hearing onset. Read More

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http://link.springer.com/10.1007/s10162-019-00719-1
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http://dx.doi.org/10.1007/s10162-019-00719-1DOI Listing
April 2019
3 Reads

Evaluating Psychophysical Polarity Sensitivity as an Indirect Estimate of Neural Status in Cochlear Implant Listeners.

J Assoc Res Otolaryngol 2019 Apr 4. Epub 2019 Apr 4.

Massachusetts Eye and Ear, 243 Charles St., Boston, MA, 02114, USA.

The physiological integrity of spiral ganglion neurons is presumed to influence cochlear implant (CI) outcomes, but it is difficult to measure neural health in CI listeners. Modeling data suggest that, when peripheral processes have degenerated, anodic stimulation may be a more effective neural stimulus than cathodic stimulation. The primary goal of the present study was to evaluate the emerging theory that polarity sensitivity reflects neural health in CI listeners. Read More

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http://link.springer.com/10.1007/s10162-019-00718-2
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http://dx.doi.org/10.1007/s10162-019-00718-2DOI Listing
April 2019
4 Reads

The Estimated Electrode-Neuron Interface in Cochlear Implant Listeners Is Different for Early-Implanted Children and Late-Implanted Adults.

J Assoc Res Otolaryngol 2019 Mar 25. Epub 2019 Mar 25.

Department of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles St., Boston, MA, 02114, USA.

Cochlear implant (CI) programming is similar for all CI users despite limited understanding of the electrode-neuron interface (ENI). The ENI refers to the ability of each CI electrode to effectively stimulate target auditory neurons and is influenced by electrode position, neural health, cochlear geometry, and bone and tissue growth in the cochlea. Hearing history likely affects these variables, suggesting that the efficacy of each channel of stimulation differs between children who were implanted at young ages and adults who lost hearing and received a CI later in life. Read More

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http://dx.doi.org/10.1007/s10162-019-00716-4DOI Listing
March 2019
2 Reads

Towards a Mechanistic-Driven Precision Medicine Approach for Tinnitus.

J Assoc Res Otolaryngol 2019 Apr 1;20(2):115-131. Epub 2019 Mar 1.

Pittsburgh Hearing Research Center and Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

In this position review, we propose to establish a path for replacing the empirical classification of tinnitus with a taxonomy from precision medicine. The goal of a classification system is to understand the inherent heterogeneity of individuals experiencing and suffering from tinnitus and to identify what differentiates potential subgroups. Identification of different patient subgroups with distinct audiological, psychophysical, and neurophysiological characteristics will facilitate the management of patients with tinnitus as well as the design and execution of drug development and clinical trials, which, for the most part, have not yielded conclusive results. Read More

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http://dx.doi.org/10.1007/s10162-018-00709-9DOI Listing
April 2019
1 Read

A Randomized Controlled Crossover Study of the Impact of Online Music Training on Pitch and Timbre Perception in Cochlear Implant Users.

J Assoc Res Otolaryngol 2019 Feb 27. Epub 2019 Feb 27.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of California - San Francisco (UCSF), 2380 Sutter St, 1st Floor, San Francisco, CA, 94115, USA.

Cochlear implant (CI) biomechanical constraints result in impoverished spectral cues and poor frequency resolution, making it difficult for users to perceive pitch and timbre. There is emerging evidence that music training may improve CI-mediated music perception; however, much of the existing studies involve time-intensive and less readily accessible in-person music training paradigms, without rigorous experimental control paradigms. Online resources for auditory rehabilitation remain an untapped potential resource for CI users. Read More

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http://dx.doi.org/10.1007/s10162-018-00704-0DOI Listing
February 2019
1 Read

Inhibition of Histone Methyltransferase G9a Attenuates Noise-Induced Cochlear Synaptopathy and Hearing Loss.

J Assoc Res Otolaryngol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Walton Research Building, Room 403-E, 39 Sabin Street, Charleston, SC, 29425, USA.

Posttranslational modification of histones alters their interaction with DNA and nuclear proteins, influencing gene expression and cell fate. In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the human EHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice. The conditions of noise exposure used in this study led to losses of cochlear synapses and outer hair cells (OHCs) and permanent auditory threshold shifts. Read More

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http://dx.doi.org/10.1007/s10162-019-00714-6DOI Listing
February 2019
2 Reads

The Effect of Stimulus Polarity on the Relation Between Pitch Ranking and ECAP Spread of Excitation in Cochlear Implant Users.

J Assoc Res Otolaryngol 2019 Jan 31. Epub 2019 Jan 31.

Boys Town National Research Hospital, Omaha, NE, 68131, USA.

Although modern cochlear implants (CIs) use cathodic-leading symmetrical biphasic pulses to stimulate the auditory nerve, a growing body of evidence suggests that anodic-leading pulses may be more effective. The positive polarity has been shown to produce larger electrically evoked compound action potential (ECAP) amplitudes, steeper slope of the amplitude growth function, and broader spread of excitation (SOE) patterns. Polarity has also been shown to influence pitch perception. Read More

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http://dx.doi.org/10.1007/s10162-018-00712-0DOI Listing
January 2019
1 Read

Effects of Musical Training and Hearing Loss on Fundamental Frequency Discrimination and Temporal Fine Structure Processing: Psychophysics and Modeling.

J Assoc Res Otolaryngol 2019 Jan 28. Epub 2019 Jan 28.

Hearing Systems Group, Department of Electrical Engineering, Technical University of Denmark, Ørsteds Plads, Building 352, 2800, Lyngby, Denmark.

Several studies have shown that musical training leads to improved fundamental frequency (F) discrimination for young listeners with normal hearing (NH). It is unclear whether a comparable effect of musical training occurs for listeners whose sensory encoding of F is degraded. To address this question, the effect of musical training was investigated for three groups of listeners (young NH, older NH, and older listeners with hearing impairment, HI). Read More

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http://link.springer.com/10.1007/s10162-018-00710-2
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http://dx.doi.org/10.1007/s10162-018-00710-2DOI Listing
January 2019
6 Reads

Neural Switch Asymmetry in Feature-Based Auditory Attention Tasks.

J Assoc Res Otolaryngol 2019 Apr 23;20(2):205-215. Epub 2019 Jan 23.

Institute for Learning and Brain Sciences, University of Washington, 1715 Columbia Rd NE, Box 357988, 98195-7988, Seattle, WA, 98195, USA.

Active listening involves dynamically switching attention between competing talkers and is essential to following conversations in everyday environments. Previous investigations in human listeners have examined the neural mechanisms that support switching auditory attention within the acoustic featural cues of pitch and auditory space. Here, we explored the cortical circuitry underlying endogenous switching of auditory attention between pitch and spatial cues necessary to discern target from masker words. Read More

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http://dx.doi.org/10.1007/s10162-018-00713-zDOI Listing
April 2019
2 Reads

Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology.

J Assoc Res Otolaryngol 2019 Feb 11;20(1):1-19. Epub 2019 Jan 11.

Department of Biological Structure, University of Washington, Health Sciences Building H-501, 1959 NE Pacific Street, Box 357420, Seattle, WA, 98195-7420, USA.

Although perhaps best known for their use in developmental studies, over the last couple of decades, zebrafish have become increasingly popular model organisms for investigating auditory system function and disease. Like mammals, zebrafish possess inner ear mechanosensory hair cells required for hearing, as well as superficial hair cells of the lateral line sensory system, which mediate detection of directional water flow. Complementing mammalian studies, zebrafish have been used to gain significant insights into many facets of hair cell biology, including mechanotransduction and synaptic physiology as well as mechanisms of both hereditary and acquired hair cell dysfunction. Read More

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http://dx.doi.org/10.1007/s10162-018-00711-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364261PMC
February 2019
3 Reads

Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness.

J Assoc Res Otolaryngol 2019 Feb 8;20(1):37-56. Epub 2019 Jan 8.

Eaton-Peabody Laboratories, Massachusetts Eye & Ear, Boston, MA, 02114, USA.

Users of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Read More

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http://link.springer.com/10.1007/s10162-018-00708-w
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http://dx.doi.org/10.1007/s10162-018-00708-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364264PMC
February 2019
23 Reads

Interaural Pitch-Discrimination Range Effects for Bilateral and Single-Sided-Deafness Cochlear-Implant Users.

J Assoc Res Otolaryngol 2019 Apr 8;20(2):187-203. Epub 2019 Jan 8.

National Military Audiology and Speech Pathology Center, Walter Reed National Military Medical Center, Bethesda, MD, 20889, USA.

By allowing bilateral access to sound, bilateral cochlear implants (BI-CIs) or unilateral CIs for individuals with single-sided deafness (SSD; i.e., normal or near-normal hearing in one ear) can improve sound localization and speech understanding in noise. Read More

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http://dx.doi.org/10.1007/s10162-018-00707-xDOI Listing
April 2019
9 Reads

A New Model for Congenital Vestibular Disorders.

J Assoc Res Otolaryngol 2019 Apr 18;20(2):133-149. Epub 2018 Dec 18.

Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, 2300 I Street NW, Washington, DC, 20037, USA.

Many developmental disorders of the inner ear are manifested clinically as delayed motor development and challenges in maintaining posture and balance, indicating involvement of central vestibular circuits. How the vestibular circuitry is rewired in pediatric cases is poorly understood due to lack of a suitable animal model. Based on this, our lab designed and validated a chick embryo model to study vestibular development in congenital vestibular disorders. Read More

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http://dx.doi.org/10.1007/s10162-018-00705-zDOI Listing
April 2019
1 Read

Effect of Chronic Stimulation and Stimulus Level on Temporal Processing by Cochlear Implant Listeners.

J Assoc Res Otolaryngol 2019 Apr 12;20(2):169-185. Epub 2018 Dec 12.

Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB2 7EF, UK.

A series of experiments investigated potential changes in temporal processing during the months following activation of a cochlear implant (CI) and as a function of stimulus level. Experiment 1 tested patients on the day of implant activation and 2 and 6 months later. All stimuli were presented using direct stimulation of a single apical electrode. Read More

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http://dx.doi.org/10.1007/s10162-018-00706-yDOI Listing
April 2019
1 Read

Speech Perception with Spectrally Non-overlapping Maskers as Measure of Spectral Resolution in Cochlear Implant Users.

J Assoc Res Otolaryngol 2019 Apr 19;20(2):151-167. Epub 2018 Nov 19.

Department of Psychology, University of Minnesota, N218 Elliott Hall, 75 East River Parkway, Minneapolis, MN, 55455, USA.

Poor spectral resolution contributes to the difficulties experienced by cochlear implant (CI) users when listening to speech in noise. However, correlations between measures of spectral resolution and speech perception in noise have not always been found to be robust. It may be that the relationship between spectral resolution and speech perception in noise becomes clearer in conditions where the speech and noise are not spectrally matched, so that improved spectral resolution can assist in separating the speech from the masker. Read More

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http://dx.doi.org/10.1007/s10162-018-00702-2DOI Listing
April 2019
14 Reads

Time-Compressed Speech Identification Is Predicted by Auditory Neural Processing, Perceptuomotor Speed, and Executive Functioning in Younger and Older Listeners.

J Assoc Res Otolaryngol 2019 Feb 19;20(1):73-88. Epub 2018 Nov 19.

Department of Otolaryngology, Medical University of South Carolina, 135 Rutledge Avenue, MSC 550, Charleston, SC, 29425-5500, USA.

Older adults typically have difficulty identifying speech that is temporally distorted, such as reverberant, accented, time-compressed, or interrupted speech. These difficulties occur even when hearing thresholds fall within a normal range. Auditory neural processing speed, which we have previously found to predict auditory temporal processing (auditory gap detection), may interfere with the ability to recognize phonetic features as they rapidly unfold over time in spoken speech. Read More

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http://dx.doi.org/10.1007/s10162-018-00703-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364265PMC
February 2019
18 Reads

Vestibular Evoked Myographic Correlation.

J Assoc Res Otolaryngol 2019 Feb 12;20(1):99-114. Epub 2018 Nov 12.

ENT Clinic, Münster University Hospital, Kardinal-von-Galen-Ring 10, 48129, Münster, Germany.

This work started from the hypothesis that the physiological processes giving rise to the vestibular evoked myogenic potential (VEMP) can be induced not only by transient sounds but also by a continuous stimulation with a stochastic signal. The hypothesis is based on the idea that the number of motor unit action potentials (MUAPs) decreases after a momentary amplitude increase of the effective stimulus, whereas a momentary amplitude decrease has the opposite effect. This concept was theoretically analyzed by assuming that the effective stimulus is closely related to the envelope of the stimulus actually presented. Read More

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http://dx.doi.org/10.1007/s10162-018-00698-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364267PMC
February 2019
3 Reads

Interaction Between Pitch and Timbre Perception in Normal-Hearing Listeners and Cochlear Implant Users.

J Assoc Res Otolaryngol 2019 Feb 30;20(1):57-72. Epub 2018 Oct 30.

College of Health Solutions, Arizona State University, Coor Hall, 975 S. Myrtle Av., P. O. Box 870102, Tempe, AZ, 85287, USA.

Despite their mutually exclusive definitions, pitch and timbre perception interact with each other in normal-hearing (NH) listeners. Cochlear implant (CI) users have worse than normal pitch and timbre perception. However, the pitch-timbre interaction with CIs is not well understood. Read More

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http://dx.doi.org/10.1007/s10162-018-00701-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364262PMC
February 2019
1 Read

Amplitude Modulation Detection in Children with a History of Temporary Conductive Hearing Loss Remains Impaired for Years After Restoration of Normal Hearing.

J Assoc Res Otolaryngol 2019 Feb 17;20(1):89-98. Epub 2018 Oct 17.

Department of Otolaryngology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 629, Rochester, NY, 14642, USA.

Otitis media with effusion (OME) is considered a form of relative sensory deprivation that often occurs during a critical period of language acquisition in children. Animal studies have demonstrated that hearing loss during early development can impair behavioral sensitivity to amplitude modulation (AM), critical for speech understanding, even after restoration of normal hearing thresholds. AM detection in humans with a history of OME-associated conductive hearing loss (CHL) has not been previously investigated. Read More

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http://link.springer.com/10.1007/s10162-018-00699-8
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http://dx.doi.org/10.1007/s10162-018-00699-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364263PMC
February 2019
5 Reads

Study of the Mechanisms by Which Aminoglycoside Damage Is Prevented in Chick Embryonic Hair Cells.

J Assoc Res Otolaryngol 2019 Feb 18;20(1):21-35. Epub 2018 Oct 18.

Department of Otorhinolaryngology, The General Hospital of the PLA Rocket Force, Beijing, 100088, China.

A major side effect of aminoglycoside antibiotics is mammalian hair cell death. It is thus intriguing that embryonic chick hair cells treated with aminoglycosides at embryonic day (E) 12 are insensitive to ototoxicity. To exclude some unknown factors in vivo that might be involved in preventing aminoglycoside damage to embryonic hair cells, we first cultured chick embryonic basilar papilla (BP) with an aminoglycoside antibiotic in vitro. Read More

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http://link.springer.com/10.1007/s10162-018-00700-4
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http://dx.doi.org/10.1007/s10162-018-00700-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364266PMC
February 2019
12 Reads

Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear.

J Assoc Res Otolaryngol 2018 Dec 27;19(6):703-715. Epub 2018 Sep 27.

Department of ORL, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). Read More

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http://dx.doi.org/10.1007/s10162-018-00697-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249156PMC
December 2018
4 Reads

Human Vestibulo-Ocular Reflex Adaptation Training: Time Beats Quantity.

J Assoc Res Otolaryngol 2018 Dec 24;19(6):729-739. Epub 2018 Sep 24.

Balance and Vision Laboratory, Neuroscience Research Australia, Cnr Barker Street & Easy Street, Randwick, NSW, 2031, Australia.

The vestibulo-ocular reflex (VOR) is the main gaze stabilising system during rapid head movements. The VOR is highly plastic and its gain (eye/head velocity) can be increased via training that induces an incrementally increasing retinal image slip error signal to drive VOR adaptation. Using the unilateral incremental VOR adaptation technique and horizontal active head impulses as the vestibular stimulus, we sought to determine the factors important for VOR adaptation including: the total training time, ratio and number of head impulses to each side (adapting and non-adapting sides; the adapting side was pseudo-randomised left or right) and exposure time to the visual target during each head impulse. Read More

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http://dx.doi.org/10.1007/s10162-018-00689-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249163PMC
December 2018
1 Read

The Masked ABR (mABR): a New Measurement Method for the Auditory Brainstem Response.

J Assoc Res Otolaryngol 2018 Dec 20;19(6):753-761. Epub 2018 Sep 20.

Institute of Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

The auditory brainstem response (ABR) is relatively non-invasive, and in many species, the only practical way to assess auditory sensitivity. The two main methods for measuring ABR are using either transients or tone bursts as a stimulus. The transient stimulus produces strong neural responses that contain no frequency information. Read More

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http://dx.doi.org/10.1007/s10162-018-00696-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249162PMC
December 2018
5 Reads

Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners.

J Assoc Res Otolaryngol 2018 Dec 19;19(6):669-680. Epub 2018 Sep 19.

Autifony Therapeutics Limited, Imperial College Incubator, London, UK.

Temporal processing by cochlear implant listeners is degraded and is affected by auditory deprivation. The fast-acting Kv3.1 potassium channel is important for sustained temporally accurate firing and is also susceptible to deprivation, the effects of which can be partially restored in animals by the molecule AUT00063. Read More

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http://dx.doi.org/10.1007/s10162-018-00694-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249161PMC
December 2018
3 Reads

The Stress Response in the Non-sensory Cells of the Cochlea Under Pathological Conditions-Possible Role in Mediating Noise Vulnerability.

J Assoc Res Otolaryngol 2018 Dec 6;19(6):637-652. Epub 2018 Sep 6.

Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, P.O. Box 65, 00014, Helsinki, Finland.

Various stressors, such as loud sounds and the effects of aging, impair the function and viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological changes in the cochlear non-sensory cells as well. We have here studied the stress response mounted in the lateral wall of the cochlea during acute noise stress and during age-related chronic stress. Read More

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http://link.springer.com/10.1007/s10162-018-00691-2
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http://dx.doi.org/10.1007/s10162-018-00691-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249157PMC
December 2018
5 Reads

Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish.

J Assoc Res Otolaryngol 2018 Dec 6;19(6):741-752. Epub 2018 Sep 6.

Department of Psychology, University of Washington, Seattle, WA, 98195, USA.

Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on sensorimotor behaviors of larval (5-7 days post-fertilization) zebrafish (Danio rerio), particularly the auditory-evoked startle response and hearing sensitivity to acoustic startle stimuli. We observed a temporary 10-15 dB decrease in startle response threshold after 18 h of flat-spectrum noise exposure at 20 dB re·1 ms. Read More

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http://dx.doi.org/10.1007/s10162-018-00685-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249159PMC
December 2018
1 Read

Surface Motion of Tympanic Membrane in a Chinchilla Model of Acute Otitis Media.

J Assoc Res Otolaryngol 2018 Dec 6;19(6):619-635. Epub 2018 Sep 6.

School of Aerospace and Mechanical Engineering and Biomedical Engineering Center, University of Oklahoma, 865 Asp Avenue, Room 200, Norman, OK, 73019, USA.

The conductive hearing loss caused by acute otitis media (AOM) is commonly related to a reduction of the tympanic membrane (TM) mobility in response to sound stimuli. However, spatial alterations of the TM surface motion associated with AOM have rarely been addressed. In this study, the TM surface motion was determined using scanning laser Doppler vibrometry (SLDV) in a chinchilla model of AOM. Read More

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http://dx.doi.org/10.1007/s10162-018-00683-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249160PMC
December 2018
6 Reads

Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals.

J Assoc Res Otolaryngol 2018 Dec 6;19(6):681-702. Epub 2018 Sep 6.

Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 243 Charles St, Boston, MA, 02114, USA.

Bilateral cochlear implant (CI) users have poor perceptual sensitivity to interaural time differences (ITDs), which limits their ability to localize sounds and understand speech in noisy environments. This is especially true for high-rate (> 300 pps) periodic pulse trains, which are used as carriers in CI processors. Here, we investigate a novel stimulation strategy in which extra pulses are added to high-rate periodic pulse trains to introduce short inter-pulse intervals (SIPIs). Read More

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http://dx.doi.org/10.1007/s10162-018-00693-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249155PMC
December 2018
1 Read

Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.

J Assoc Res Otolaryngol 2018 Dec 5;19(6):653-668. Epub 2018 Sep 5.

Translational Research Center, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.

Noise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of the Stephania tetrandra S. Read More

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http://dx.doi.org/10.1007/s10162-018-00690-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249158PMC
December 2018
6 Reads

Correction to: Effect of Stimulus Polarity on Detection Thresholds in Cochlear Implant Users: Relationships with Average Threshold, Gap Detection, and Rate Discrimination.

J Assoc Res Otolaryngol 2018 10;19(5):569

Department of Speech and Hearing Sciences, University of Washington, 1417 NE 42nd St, Seattle, WA, 98105, USA.

The middle initial of Julie G. Arenberg's name was incorrect in the original publication; it is correct as displayed here. Read More

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http://link.springer.com/10.1007/s10162-018-00695-y
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http://dx.doi.org/10.1007/s10162-018-00695-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226414PMC
October 2018
3 Reads

Intracochlear Sound Pressure Measurements in Normal Human Temporal Bones During Bone Conduction Stimulation.

J Assoc Res Otolaryngol 2018 10 31;19(5):523-539. Epub 2018 Aug 31.

Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.

Bone conduction (BC) is heavily relied upon in the diagnosis and treatment of hearing loss, but is poorly understood. For example, the relative importance and frequency dependence of various identified BC sound transmission mechanisms that contribute to activate the cochlear partition remain unknown. Recently, we have developed techniques in fresh human cadaveric specimens to directly measure scalae pressures with micro-fiberoptic sensors, enabling us to monitor the input pressure drive across the cochlear partition that triggers the cochlear traveling wave during air conduction (AC) and round-window stimulation. Read More

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http://link.springer.com/10.1007/s10162-018-00684-1
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http://dx.doi.org/10.1007/s10162-018-00684-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226413PMC
October 2018
5 Reads

Effects of 3,3'-Iminodipropionitrile on Hair Cell Numbers in Cristae of CBA/CaJ and C57BL/6J Mice.

J Assoc Res Otolaryngol 2018 10 31;19(5):483-491. Epub 2018 Aug 31.

Department of Biological Structure, University of Washington, 1959 NE Pacific St., Box 357420, Seattle, WA, 98195, USA.

This study examines absolute hair cell numbers in the cristae of C57BL/6J mice and CBA/CaJ mice from weaning to adulthood as well as the dose required for 3,3'-iminodiproprionitrile (IDPN)-injury of the cristae in C57BL/6J mice and CBA/CaJ mice, the two mouse strains most commonly used by inner ear researchers. In cristae of CBA/CaJ and C57BL/6J mice, no loss of hair cells was observed up to 24 weeks. In both strains, dose-dependent loss of hair cells was observed 7 days after IDPN treatment of 2-month-old mice (IC = 16. Read More

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http://dx.doi.org/10.1007/s10162-018-00687-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226411PMC
October 2018
9 Reads

Effects of Masker Envelope Fluctuations on the Temporal Effect.

J Assoc Res Otolaryngol 2018 Dec 20;19(6):717-727. Epub 2018 Aug 20.

Department of Communication Sciences and Disorders, The University of Utah, 390 South, 1530 East, BEHS 1201, Salt Lake City, UT, 84112, USA.

Under certain conditions, detection thresholds in simultaneous masking improve when the onset of a short sinusoidal probe is delayed from the onset of a long masker. This improvement, known as the temporal effect, is largest for broadband maskers and is smaller or absent for narrowband maskers centered on the probe frequency. This study tests the hypothesis that small or absent temporal effects for narrowband maskers are due to the inherent temporal envelope fluctuations of Gaussian noise. Read More

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http://dx.doi.org/10.1007/s10162-018-00688-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249164PMC
December 2018
25 Reads

Human Vestibulo-Ocular Reflex Adaptation: Consolidation Time Between Repeated Training Blocks Improves Retention.

J Assoc Res Otolaryngol 2018 10 17;19(5):601-610. Epub 2018 Aug 17.

Balance and Vision Laboratory, Neuroscience Research Australia, Cnr Barker Street & Easy Street, Randwick, Sydney, NSW, 2031, Australia.

We sought to determine if separating vestibulo-ocular reflex (VOR) adaptation training into training blocks with a consolidation (rest) period in between repetitions would result in improved VOR adaptation and retention. Consolidation of motor learning refers to the brain benefitting from a rest period after prior exposure to motor training. The role of consolidation on VOR adaptation is unknown, though clinicians often recommend rest periods as a part of vestibular rehabilitation. Read More

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http://link.springer.com/10.1007/s10162-018-00686-z
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http://dx.doi.org/10.1007/s10162-018-00686-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226406PMC
October 2018
10 Reads

Correction to: Aminoglycoside Damage and Hair Cell Regeneration in the Chicken Utricle.

J Assoc Res Otolaryngol 2018 08;19(4):479-481

Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.

This article was updated to correct a formatting error in Table 1. Read More

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http://dx.doi.org/10.1007/s10162-018-0667-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081890PMC
August 2018
1 Read

Spectral Ripples in Round-Window Cochlear Microphonics: Evidence for Multiple Generation Mechanisms.

J Assoc Res Otolaryngol 2018 08 16;19(4):401-419. Epub 2018 Jul 16.

Auditory Research Center, Caruso Department of Otolarygnology, University of Southern California, Los Angeles, CA, USA.

The cochlear microphonic (CM) results from the vector sum of outer hair cell transduction currents excited by a stimulus. The classical theory of CM generation-that the response measured at the round window is dominated by cellular sources located within the tail region of the basilar membrane (BM) excitation pattern-predicts that CM amplitude and phase vary little with stimulus frequency. Contrary to expectations, CM amplitude and phase-gradient delay measured in response to low-level tones in chinchillas demonstrate a striking, quasiperiodic pattern of spectral ripples, even at frequencies > 5 kHz, where interference with neurophonic potentials is unlikely. Read More

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http://dx.doi.org/10.1007/s10162-018-0668-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081886PMC
August 2018
6 Reads

Chronic Deafness Degrades Temporal Acuity in the Electrically Stimulated Auditory Pathway.

J Assoc Res Otolaryngol 2018 10 2;19(5):541-557. Epub 2018 Jul 2.

Department of Otolaryngology, University of California at Irvine, Irvine, CA, 92697-5310, USA.

Electrical stimulation of the auditory nerve with a penetrating intraneural (IN) electrode in acutely deafened cats produces much more restricted spread of excitation than is obtained in that preparation with a conventional cochlear implant (CI) as reported by Middlebrooks and Snyder (J Assoc Res Otolaryngol 8:258-279, 2007). That suggests that a future auditory prosthesis employing IN stimulation might offer human patients greater frequency selectivity than is available with a present-day CI. Nevertheless, it is a concern that the electrical field produced by an IN electrode might be too restricted to produce adequate stimulation of the partially depopulated auditory nerve of a deaf patient. Read More

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http://link.springer.com/10.1007/s10162-018-0679-3
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http://dx.doi.org/10.1007/s10162-018-0679-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226412PMC
October 2018
2 Reads

Reflection- and Distortion-Source Otoacoustic Emissions: Evidence for Increased Irregularity in the Human Cochlea During Aging.

J Assoc Res Otolaryngol 2018 10 2;19(5):493-510. Epub 2018 Jul 2.

Auditory Research Center, Caruso Department of Otolaryngology, University of Southern California, 1640 Marengo Street, Suite 346, Los Angeles, CA, 90033, USA.

Previous research on distortion product otoacoustic emission (DPOAE) components has hinted at possible differences in the effect of aging on the two basic types of OAEs: those generated by a reflection mechanism in the cochlea and those created by nonlinear distortion (Abdala and Dhar in J Assoc Res Otolaryngol 13:403-421, 2012). This initial work led to the hypothesis that micromechanical irregularity ("roughness") increases in the aging cochlea, perhaps as the result of natural tissue degradation. Increased roughness would boost the backscattering of traveling waves (i. Read More

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http://dx.doi.org/10.1007/s10162-018-0680-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226410PMC
October 2018
4 Reads

Modeling the dependence of the distortion product otoacoustic emission response on primary frequency ratio.

J Assoc Res Otolaryngol 2018 10 26;19(5):511-522. Epub 2018 Jun 26.

Physics Department, University of Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133, Rome, Italy.

When measured as a function of primary frequency ratio r = f/f, using a constant f, distortion product otoacoustic emission (DPOAE) response demonstrates a bandpass shape, previously interpreted as the evidence for a cochlear "second filter." In this study, an alternate, interference-based explanation, previously advanced in variants, is forwarded on the basis of experimental data along with numerical and analytical solutions of nonlinear and linear cochlear models. The decrease of the DPOAE response with increasing and decreasing ratios is explained by a diminishing "overlap" generation region and the onset of negative interference among wavelets of different phase, respectively. Read More

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http://dx.doi.org/10.1007/s10162-018-0681-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226407PMC
October 2018
1 Read

Effect of Stimulus Polarity on Detection Thresholds in Cochlear Implant Users: Relationships with Average Threshold, Gap Detection, and Rate Discrimination.

J Assoc Res Otolaryngol 2018 10 7;19(5):559-567. Epub 2018 Jun 7.

Department of Speech and Hearing Sciences, University of Washington, 1417 NE 42nd St., Seattle, WA, 98105, USA.

Previous psychophysical and modeling studies suggest that cathodic stimulation by a cochlear implant (CI) may preferentially activate the peripheral processes of the auditory nerve, whereas anodic stimulation may preferentially activate the central axons. Because neural degeneration typically starts with loss of the peripheral processes, lower thresholds for cathodic than for anodic stimulation may indicate good local neural survival. We measured thresholds for 99-pulse-per-second trains of triphasic (TP) pulses where the central high-amplitude phase was either anodic (TP-A) or cathodic (TP-C). Read More

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http://dx.doi.org/10.1007/s10162-018-0677-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226408PMC
October 2018
2 Reads

Platelet-Derived Growth Factor Subunit B Signaling Promotes Pericyte Migration in Response to Loud Sound in the Cochlear Stria Vascularis.

J Assoc Res Otolaryngol 2018 08 4;19(4):363-379. Epub 2018 Jun 4.

Oregon Hearing Research Center, Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, Portland, OR, 97239, USA.

Normal blood supply to the cochlea is critical for hearing. Noise damages auditory sensory cells and has a marked effect on the microvasculature in the cochlear lateral wall. Pericytes in the stria vascularis (strial pericytes) are particularly vulnerable and sensitive to acoustic trauma. Read More

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http://dx.doi.org/10.1007/s10162-018-0670-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081892PMC
August 2018
8 Reads

Psychophysical Tuning Curves as a Correlate of Electrode Position in Cochlear Implant Listeners.

J Assoc Res Otolaryngol 2018 10 4;19(5):571-587. Epub 2018 Jun 4.

Department of Speech and Hearing Sciences, University of Washington, 4131 15th Ave NE, Seattle, WA, 98106, USA.

Speech understanding abilities vary widely among cochlear implant (CI) listeners. A potential source of this variability is the electrode-neuron interface (ENI), which includes peripheral factors such as electrode position and integrity of remaining spiral ganglion neurons. Suboptimal positioning of the electrode array has been associated with poorer speech outcomes; however, postoperative computerized tomography (CT) scans are often not available to clinicians. Read More

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http://dx.doi.org/10.1007/s10162-018-0678-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226415PMC
October 2018
5 Reads

Characterization of Adult Vestibular Organs in 11 CreER Mouse Lines.

J Assoc Res Otolaryngol 2018 08 4;19(4):381-399. Epub 2018 Jun 4.

Departments of Pharmacology and Surgery, Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Utricles are vestibular sense organs that encode linear head movements. They are composed of a sensory epithelium with type I and type II hair cells and supporting cells, sitting atop connective tissue, through which vestibular nerves project. We characterized utricular Cre expression in 11 murine CreER lines using the ROSA26 reporter line and tamoxifen induction at 6 weeks of age. Read More

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http://dx.doi.org/10.1007/s10162-018-0676-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081895PMC
August 2018
25 Reads

Contribution of Cochlear Compression to Discrimination of Rippled Spectra in On- and Low-frequency Noise.

J Assoc Res Otolaryngol 2018 10 21;19(5):611-618. Epub 2018 May 21.

Institute of Ecology and Evolution of Russian Academy of Sciences, 33 Leninsky prospect, Moscow, Russia, 119071.

The goal of the study was to assess cochlear compression when rippled-spectrum signals are perceived in noise assuming that the noise might produce both masking and confounding effects. In normal listeners, discrimination between rippled signals with and without ripple phase reversals was assessed in background noise. The signals were band-limited (0. Read More

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http://dx.doi.org/10.1007/s10162-018-0674-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226409PMC
October 2018
3 Reads

Intensity Discrimination and Speech Recognition of Cochlear Implant Users.

J Assoc Res Otolaryngol 2018 10 17;19(5):589-600. Epub 2018 May 17.

Bionics Institute, 384-388 Albert St, East Melbourne, 3002, Australia.

The relation between speech recognition and within-channel or across-channel (i.e., spectral tilt) intensity discrimination was measured in nine CI users (11 ears). Read More

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http://dx.doi.org/10.1007/s10162-018-0675-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226416PMC
October 2018
3 Reads

Tone-Evoked Acoustic Change Complex (ACC) Recorded in a Sedated Animal Model.

J Assoc Res Otolaryngol 2018 08 10;19(4):451-466. Epub 2018 May 10.

Department of Otolaryngology, University of California at Irvine, Irvine, CA, 92697-5310, USA.

The acoustic change complex (ACC) is a scalp-recorded cortical evoked potential complex generated in response to changes (e.g., frequency, amplitude) in an auditory stimulus. Read More

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http://dx.doi.org/10.1007/s10162-018-0673-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081888PMC
August 2018
2 Reads

Factors Affecting Speech Reception in Background Noise with a Vocoder Implementation of the FAST Algorithm.

J Assoc Res Otolaryngol 2018 08 9;19(4):467-478. Epub 2018 May 9.

Department of Otolaryngology, University of Southern California, Los Angeles, CA, USA.

Speech segregation in background noise remains a difficult task for individuals with hearing loss. Several signal processing strategies have been developed to improve the efficacy of hearing assistive technologies in complex listening environments. The present study measured speech reception thresholds in normal-hearing listeners attending to a vocoder based on the Fundamental Asynchronous Stimulus Timing algorithm (FAST: Smith et al. Read More

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http://dx.doi.org/10.1007/s10162-018-0672-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081891PMC
August 2018
2 Reads

Persistent Auditory Nerve Damage Following Kainic Acid Excitotoxicity in the Budgerigar (Melopsittacus undulatus).

J Assoc Res Otolaryngol 2018 08 9;19(4):435-449. Epub 2018 May 9.

Department of Otolaryngology, University of Rochester, 601 Elmwood Ave., Box 629, Rochester, NY, 14642, USA.

Permanent loss of auditory nerve (AN) fibers occurs with increasing age and sound overexposure, sometimes without hair cell damage or associated audiometric threshold elevation. Rodent studies suggest effects of AN damage on central processing and behavior, but these species have limited capacity to discriminate low-frequency speech-like sounds. Here, we introduce a new animal model of AN damage in an avian communication specialist, the budgerigar (Melopsittacus undulatus). Read More

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http://dx.doi.org/10.1007/s10162-018-0671-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081894PMC
August 2018
3 Reads

Supra-Threshold Hearing and Fluctuation Profiles: Implications for Sensorineural and Hidden Hearing Loss.

Authors:
Laurel H Carney

J Assoc Res Otolaryngol 2018 08 9;19(4):331-352. Epub 2018 May 9.

Departments of Biomedical Engineering, Neuroscience, and Electrical & Computer Engineering, Del Monte Institute for Neuroscience, University of Rochester, 601 Elmwood Ave., Box 603, Rochester, NY, 14642, USA.

An important topic in contemporary auditory science is supra-threshold hearing. Difficulty hearing at conversational speech levels in background noise has long been recognized as a problem of sensorineural hearing loss, including that associated with aging (presbyacusis). Such difficulty in listeners with normal thresholds has received more attention recently, especially associated with descriptions of synaptopathy, the loss of auditory nerve (AN) fibers as a result of noise exposure or aging. Read More

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http://dx.doi.org/10.1007/s10162-018-0669-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081887PMC
August 2018
6 Reads

Click-Evoked Auditory Efferent Activity: Rate and Level Effects.

J Assoc Res Otolaryngol 2018 08 7;19(4):421-434. Epub 2018 May 7.

Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, and The Knowles Hearing Center, Northwestern University, Evanston, IL, USA.

There currently are no standardized protocols to evaluate auditory efferent function in humans. Typical tests use broadband noise to activate the efferents, but only test the contralateral efferent pathway, risk activating the middle ear muscle reflex (MEMR), and are laborious for clinical use. In an attempt to develop a clinical test of bilateral auditory efferent function, we have designed a method that uses clicks to evoke efferent activity, obtain click-evoked otoacoustic emissions (CEOAEs), and monitor MEMR. Read More

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http://dx.doi.org/10.1007/s10162-018-0664-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081889PMC
August 2018
2 Reads