3,843 results match your criteria Journal of the American Heart Association[Journal]


Changes in Childhood Body-Mass Index and Risk of Venous Thromboembolism in Adulthood.

J Am Heart Assoc 2019 Mar;8(6):e011407

1 Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark.

Background Childhood weight trajectories may influence cardiometabolic traits and thereby the risk of venous thromboembolism ( VTE ) later in life. We examined whether overweight and changes in weight status during childhood were associated with risk of VTE in adulthood. Methods and Results We used Danish medical registries to conduct a population-based cohort study of Danish schoolchildren aged 7 to 13 years and born during 1930-1989. Read More

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http://dx.doi.org/10.1161/JAHA.118.011407DOI Listing
March 2019
1 Read

Metabolic Risk Factors and Left Ventricular Diastolic Function in Middle-Aged Chinese Living in the Tibetan Plateau.

J Am Heart Assoc 2019 Mar;8(6):e010454

1 State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Disease Division of Prevention and Community Health National Center for Cardiovascular Disease Fuwai Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China.

Background Data regarding the metabolic risk factors clustering on the risk of left ventricular diastolic dysfunction ( LVDD ) are lacking among people living at high altitude and under hypoxic conditions. In this study, we explored the association between metabolic risk factor clustering and LVDD among the Tibetan population of China. Methods and Results We conducted a cross-sectional survey in a representative sample of 1963 Tibetans in 2014 to 2016. Read More

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http://dx.doi.org/10.1161/JAHA.118.010454DOI Listing

High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis.

J Am Heart Assoc 2019 Mar;8(6):e008626

1 Department of Anesthesiology Washington University School of Medicine in St. Louis MO.

Background The recent introduction of high-sensitivity cardiac troponin (hs-cTn) assays has allowed clinicians to measure hs-cTn before and after cardiac stress testing, but the hs-cTn release pattern and potential utility in identifying inducible myocardial ischemia are unclear. We thus conducted a systematic review and meta-analysis to improve our understanding of hs-cTn release associated with exercise and pharmacological stress testing. Methods and Results Studies published between January 2008 and July 2016 that reported hs-cTn change values (high-sensitivity cardiac troponin T [hs-cTnT] or high-sensitivity cardiac troponin I [hs-cTnI]) in relation to cardiac stress testing were searched and reviewed by 2 independent screeners. Read More

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http://dx.doi.org/10.1161/JAHA.118.008626DOI Listing
March 2019
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Thoracic Aortic Dissection in Tetralogy of Fallot: A Review of the National Inpatient Sample Database.

J Am Heart Assoc 2019 Mar;8(6):e011943

1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Thoracic aortic aneurysm is common in patients with tetralogy of Fallot ( TOF ); the incidence of thoracic aortic dissection ( TAD ) is unknown, but generally considered to be uncommon. The purpose of this study was to determine incidence and risk factors for TAD in TOF patients. Methods and Results This work is a retrospective review of the National Inpatient Sample ( NIS ) database for cases of ascending TAD among all hospital admissions in adults with TOF , 2000-2014. Read More

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http://dx.doi.org/10.1161/JAHA.119.011943DOI Listing

Breastfeeding and Cardiovascular Disease Hospitalization and Mortality in Parous Women: Evidence From a Large Australian Cohort Study.

J Am Heart Assoc 2019 Mar;8(6):e011056

1 Prevention Research Collaboration Sydney School of Public Health The University of Sydney Camperdown New South Wales Australia.

Background Few studies have investigated the longitudinal association between breastfeeding and maternal cardiovascular disease ( CVD ) outcomes. This study examined the association between breastfeeding and CVD hospitalization and mortality in a large Australian cohort. Methods and Results Baseline questionnaire data (2006-2009) from a sample of 100 864 parous women aged ≥45 years from New South Wales, Australia, were linked to hospitalization and death data until June 2014 and December 2013, respectively. Read More

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http://dx.doi.org/10.1161/JAHA.118.011056DOI Listing

Accuracy of Left Ventricular Cavity Volume and Ejection Fraction for Conventional Estimation Methods and 3D Surface Fitting.

Authors:
Walter G O'Dell

J Am Heart Assoc 2019 Mar;8(6):e009124

1 Department of Radiation Oncology University of Florida College of Medicine Gainesville FL.

Background While left ventricular cavity volume ( LVV ) and ejection fraction ( LVEF ) are used routinely for clinical decision-making, the errors in LVV and LVEF estimates in the clinic have yet to be rigorously quantified and are perhaps underappreciated. Methods and Results The goal of this study was to quantify the accuracy and precision of several common geometric-model-based methods for estimating LVV and LVEF using a highly sampled, high-resolution magnetic resonance imaging data set and an independent ground truth. The effect on LVV and LVEF accuracy of slice number and orientation was also studied. Read More

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http://dx.doi.org/10.1161/JAHA.118.009124DOI Listing

Severe Symptomatic Aortic Stenosis? Check Troponin, Too.

J Am Heart Assoc 2019 Mar;8(6):e012156

2 Department of Cardiothoracic and Vascular Surgery University of Texas Health Science Center, Houston McGovern Medical School Houston TX.

See Article by Akodad et al. Read More

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http://dx.doi.org/10.1161/JAHA.119.012156DOI Listing

Glucocorticoid Receptor-Binding and Transcriptome Signature in Cardiomyocytes.

J Am Heart Assoc 2019 Mar;8(6):e011484

1 Department of Cell Biology and Molecular Medicine Rutgers New Jersey Medical School Newark NJ.

Background An increase in serum cortisol has been identified as a risk factor for cardiac failure, which highlights the impact of glucocorticoid signaling in cardiomyocytes and its influence in the progression of failure. Dexamethasone, a synthetic glucocorticoid, is sufficient for induction of cardiomyocyte hypertrophy, but little is known of the glucocorticoid receptor (GR) genome-binding and -dependent transcriptional changes that mediate this phenotype. Methods and Results In this study using high-resolution sequencing, we identified genomic targets of GR and associated change in the transcriptome after 1 and 24 hours of dexamethasone treatment. Read More

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http://dx.doi.org/10.1161/JAHA.118.011484DOI Listing

Degradation of Glycocalyx and Multiple Manifestations of Endothelial Dysfunction Coincide in the Early Phase of Endothelial Dysfunction Before Atherosclerotic Plaque Development in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice.

J Am Heart Assoc 2019 Mar;8(6):e011171

1 Jagiellonian University Jagiellonian Centre for Experimental Therapeutics Krakow Poland.

Background The impairment of endothelium-dependent vasodilation, increased endothelial permeability, and glycocalyx degradation are all important pathophysiological components of endothelial dysfunction. However, it is still not clear whether in atherosclerosis, glycocalyx injury precedes other features of endothelial dysfunction or these events coincide. Methods and Results Herein, we demonstrate that in 4- to 8-week-old apolipoprotein E/low-density lipoprotein receptor-deficient mice, at the stage before development of atherosclerotic plaques, impaired acetylcholine-induced vasodilation, reduced NO production in aorta, and increased endothelial permeability were all observed; however, flow-mediated dilation in the femoral artery was fully preserved. Read More

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http://dx.doi.org/10.1161/JAHA.118.011171DOI Listing

Prognostic Impact of Pre-Transcatheter and Post-Transcatheter Aortic Valve Intervention Troponin: A Large Cohort Study.

J Am Heart Assoc 2019 Mar;8(6):e011111

1 Interventional Cardiology Department Ramsay Générale de Santé Institut Cardiovasculaire Paris Sud Massy France.

Background Biomarkers were advocated as prognostic factors in patients undergoing transcatheter aortic valve intervention, with contradictory results concerning prognostic impact of troponin. Our aim was to assess the prognostic impact of preprocedural and postprocedural troponin in transcatheter aortic valve intervention. Methods and Results Preprocedural and postprocedural high-sensitivity troponin levels were measured in all patients undergoing transcatheter aortic valve intervention. Read More

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http://dx.doi.org/10.1161/JAHA.118.011111DOI Listing

Nationwide Increase in Complex Congenital Heart Diseases After the Fukushima Nuclear Accident.

J Am Heart Assoc 2019 Mar;8(6):e009486

3 Department of Cardiovascular Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Japan.

Background After the Chernobyl nuclear accident in 1986, an increase in the incidence of congenital heart disease ( CHD s) in the neighboring countries was reported. In 2011, Japan experienced the Great East Japan Earthquake and the nuclear accidents at Fukushima. However, a nationwide study of their effects has not been conducted yet. Read More

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http://dx.doi.org/10.1161/JAHA.118.009486DOI Listing

Association Between Serum High-Density Lipoprotein Cholesterol Levels and Progression of Chronic Kidney Disease: Results From the KNOW-CKD.

J Am Heart Assoc 2019 Mar;8(6):e011162

1 Department of Internal Medicine College of Medicine Institute of Kidney Disease Research Yonsei University Seoul Korea.

Background High-density lipoprotein cholesterol ( HDL -C) levels are generally decreased in patients with chronic kidney disease ( CKD ). However, studies on the relationship between HDL -C and CKD progression are scarce. Methods and Results We studied the association between serum HDL -C levels and the risk of CKD progression in 2168 participants of the KNOW - CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease). Read More

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http://dx.doi.org/10.1161/JAHA.118.011162DOI Listing

Interrelationships Between American Heart Association's Life's Simple 7, ECG Silent Myocardial Infarction, and Cardiovascular Mortality.

J Am Heart Assoc 2019 Mar;8(6):e011648

2 Epidemiological Cardiology Research Center (EPICARE) Department of Epidemiology and Prevention Wake Forest School of Medicine Winston-Salem NC.

Background We examined the interrelationships among cardiovascular health (CVH), assessed by the American Heart Association's Life's Simple 7 (LS7) health metrics, silent myocardial infarction (SMI), and cardiovascular disease (CVD) mortality. Methods and Results This analysis included 6766 participants without a history of coronary heart disease from the Third Report of the National Health and Nutrition Examination Survey. Poor, intermediate, and ideal CVH were defined as an LS7 score of 0 to 4, 5 to 9, and 10 to 14, respectively. Read More

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http://dx.doi.org/10.1161/JAHA.118.011648DOI Listing
March 2019
2 Reads

Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y Receptor Antagonist Effects in Patients With Acute Coronary Syndromes: Insights From the PLATO Trial.

J Am Heart Assoc 2019 Mar;8(6):e011139

1 University of Florida, College of Medicine-Jacksonville Jacksonville FL.

Background There are limited data on how the combination of diabetes mellitus ( DM ) and chronic kidney disease ( CKD ) affects cardiovascular outcomes as well as response to different P2Y receptor antagonists, which represented the aim of the present investigation. Methods and Results In this post hoc analysis of the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized acute coronary syndrome patients to ticagrelor versus clopidogrel, patients (n=15 108) with available DM and CKD status were classified into 4 groups: DM +/ CKD + (n=1058), DM +/ CKD - (n=2748), DM -/ CKD + (n=2160), and DM -/ CKD - (n=9142). The primary efficacy end point was a composite of cardiovascular death, myocardial infarction, or stroke at 12 months. Read More

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http://dx.doi.org/10.1161/JAHA.118.011139DOI Listing

Association Between Maternal Folic Acid Supplementation and Congenital Heart Defects in Offspring in Birth Cohorts From Denmark and Norway.

J Am Heart Assoc 2019 Mar;8(6):e011615

2 Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark.

Background Evidence linking individual-level maternal folic acid supplementation to offspring risk of congenital heart defects is lacking. We investigated whether folic acid supplementation in early pregnancy reduces offspring risk of heart defects in 2 large birth cohort studies. Methods and Results Women recruited in early pregnancy within the DNBC (Danish National Birth Cohort), 1996-2003, and MoBa (Norwegian Mother and Child Cohort Study), 2000-2009, were followed until delivery. Read More

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http://dx.doi.org/10.1161/JAHA.118.011615DOI Listing

Is Prevalence of Atherosclerotic Risk Factors Increasing Among Young Adults? It Depends on How You Ask.

J Am Heart Assoc 2019 Mar;8(6):e010883

6 Department of Neurology University of Michigan Health System Ann Arbor MI.

Background Incidence of cardiovascular disease in young adults is unabated. Increased prevalence of self-reported atherosclerotic risk factors may be driving this trend. The goal of this study was to examine whether the prevalence of atherosclerotic risk factors in young adults is increasing over time using both self-report and standard clinical criteria. Read More

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http://dx.doi.org/10.1161/JAHA.118.010883DOI Listing
March 2019
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Prognostic Importance of Defibrillator-Appropriate Shocks and Antitachycardia Pacing in Patients With Mild Heart Failure.

J Am Heart Assoc 2019 Mar;8(6):e010346

1 Heart Research Follow-Up Program Division of Cardiology Department of Medicine University of Rochester Medical Center Rochester NY.

Background Patients with heart failure and an implantable cardioverter-defibrillator ( ICD ) for primary prevention are at increased mortality risk after receiving shock therapy. We sought to determine the prognostic significance of ICD therapies, both shock and antitachycardia pacing, delivered for different ventricular arrhythmia ( VA ) rates. Methods and Results We evaluated mortality risk among 1790 ICD -implanted patients from MADIT -CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy). Read More

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http://dx.doi.org/10.1161/JAHA.118.010346DOI Listing

His Bundle Pacing: A New Strategy for Physiological Ventricular Activation.

J Am Heart Assoc 2019 Mar;8(6):e010972

1 Department of Cardiology Great Western Hospitals NHS Foundation Trust Swindon United Kingdom.

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http://dx.doi.org/10.1161/JAHA.118.010972DOI Listing

Social Factors, Sex, and Mortality Risk After Coronary Artery Bypass Grafting: A Population-Based Cohort Study.

J Am Heart Assoc 2019 Mar;8(6):e011490

1 Department of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.

Background Little is known of the impact of social factors on mortality after coronary artery bypass grafting ( CABG ). We explored sex- and age-specific associations between mortality risk after CABG and marital status, income, and education. Methods and Results This population-based register study included 110 742 CABG patients (21. Read More

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http://dx.doi.org/10.1161/JAHA.118.011490DOI Listing
March 2019
1 Read

Occupational Class and Risk of Cardiovascular Disease Incidence in Japan: Nationwide, Multicenter, Hospital-Based Case-Control Study.

J Am Heart Assoc 2019 Mar;8(6):e011350

1 Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health Boston MA.

Background In contemporary Western settings, higher occupational class is associated with lower risk for cardiovascular disease ( CVD ) incidence, including coronary heart disease ( CHD ) and stroke. However, in non-Western settings (including Japan), the occupational class gradient for cardiovascular disease risk has not been characterized. Methods and Results Using a nationwide, multicenter hospital inpatient data set (1984-2016) in Japan, we conducted a matched hospital case-control study with ≈1. Read More

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http://dx.doi.org/10.1161/JAHA.118.011350DOI Listing
March 2019
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Characteristics, Outcomes, and Treatment of Heart Failure With Improved Ejection Fraction.

J Am Heart Assoc 2019 Mar;8(6):e011077

2 Cardiovascular Center Division of Cardiology Seoul National University Bundang Hospital Seongnam Republic of Korea.

Background Many patients with heart failure ( HF ) with reduced ejection fraction ( HF r EF ) experience improvement or recovery of left ventricular ejection fraction ( LVEF ). Data on clinical characteristics, outcomes, and medical therapy in patients with HF with improved ejection fraction (HFiEF) are scarce. Methods and Results Of 5625 consecutive patients hospitalized for acute HF in the KorAHF (Registry [Prospective Cohort] for Heart Failure in Korea) study, 5103 patients had baseline echocardiography and 2302 patients had follow-up echocardiography at 12 months. Read More

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http://dx.doi.org/10.1161/JAHA.118.011077DOI Listing
March 2019
2 Reads

Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease.

J Am Heart Assoc 2019 Mar;8(6):e010748

1 Queensland Research Centre for Peripheral Vascular Disease College of Medicine and Dentistry James Cook University Townsville Queensland Australia.

Background Hypertension is an important risk factor for cardiovascular events in patients with peripheral artery disease; however, optimal blood pressure targets for these patients are poorly defined. This study investigated the association between systolic blood pressure ( SBP ) and cardiovascular events in a prospectively recruited patient cohort with peripheral artery disease. Methods and Results A total of 2773 patients were included and were grouped according to SBP at recruitment (≤120 mm Hg, n=604; 121-140 mm Hg, n=1065; and >140 mm Hg, n=1104). Read More

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http://dx.doi.org/10.1161/JAHA.118.010748DOI Listing
March 2019
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Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia.

J Am Heart Assoc 2019 Mar;8(6):e011179

6 Section of Cardiology Department of Medicine Sahlgrenska University Hospital/Östra Hospital Göteborg Sweden.

Background Angiotensin II type 1 receptor ( AT R) autoantibody ( AT 1- AA ) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II ), AT 1- AA can induce vasoconstriction in a sustained manner, causing a series of adverse effects, such as vascular injury and poor placental perfusion. However, its underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1161/JAHA.118.011179DOI Listing
March 2019
2 Reads
2.882 Impact Factor

Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study.

J Am Heart Assoc 2019 Mar;8(6):e010976

2 Section of Computational Biomedicine Department of Medicine Boston Medical Center Boston University School of Medicine Boston MA.

Background Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins. Methods and Results We performed proteomics assays among participants from the Framingham Heart Study Offspring attending their fifth examination. Plasma protein levels (n=1373) were measured by the SOMAscan proteomic profiling platform. Read More

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http://dx.doi.org/10.1161/JAHA.118.010976DOI Listing
March 2019
4 Reads

Characteristics and Prognosis of Patients With Moderate Aortic Stenosis and Preserved Left Ventricular Ejection Fraction.

J Am Heart Assoc 2019 Mar;8(6):e011036

1 Department of Cardiology Amiens University Hospital Amiens France.

Background Moderate aortic stenosis ( MAS ) has not been extensively studied and characterized, as no published study has been specifically devoted to this condition. Methods and Results We aimed to describe the characteristics of patients with MAS and to evaluate their long-term survival compared with that of the general population. This study included 508 patients (mean±SD age, 75±11 years) with MAS (aortic valve area between 1 and 1. Read More

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http://dx.doi.org/10.1161/JAHA.118.011036DOI Listing
March 2019
1 Read

"Worth the Walk": Culturally Tailored Stroke Risk Factor Reduction Intervention in Community Senior Centers.

J Am Heart Assoc 2019 Mar;8(6):e011088

1 David Geffen School of Medicine at UCLA Los Angeles CA.

Background Racial/ethnic minority older adults have worse stroke burden than non-Hispanic white and younger counterparts. Our academic-community partner team tested a culturally tailored 1-month (8-session) intervention to increase walking and stroke knowledge among Latino, Korean, Chinese, and black seniors. Methods and Results We conducted a randomized wait-list controlled trial of 233 adults aged 60 years and older, with a history of hypertension, recruited from senior centers. Read More

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http://dx.doi.org/10.1161/JAHA.118.011088DOI Listing
March 2019
1 Read

Greening of the Heart and Mind.

Authors:
John R Balmes

J Am Heart Assoc 2019 Mar;8(6):e012090

1 Department of Medicine University of California San Francisco CA.

See Article by Wang et al. Read More

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http://dx.doi.org/10.1161/JAHA.119.012090DOI Listing
March 2019
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Relationship of Neighborhood Greenness to Heart Disease in 249 405 US Medicare Beneficiaries.

J Am Heart Assoc 2019 Mar;8(6):e010258

1 University of Miami Miller School of Medicine Miami FL.

Background Nature exposures may be associated with reduced risk of heart disease. The present study examines the relationship between objective measures of neighborhood greenness (vegetative presence) and 4 heart disease diagnoses (acute myocardial infarction, ischemic heart disease, heart failure, and atrial fibrillation) in a population-based sample of Medicare beneficiaries. Methods and Results The sample included 249 405 Medicare beneficiaries aged 65 years and older whose location ( ZIP +4) in Miami-Dade County, Florida, did not change from 2010 to 2011. Read More

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http://dx.doi.org/10.1161/JAHA.118.010258DOI Listing
March 2019
4 Reads

Will Teens Go Red? Low Cardiovascular Disease Awareness Among Young Women.

J Am Heart Assoc 2019 Mar;8(6):e011195

2 Department of Pediatrics Harvard Medical School Boston MA.

Background The American Heart Association Go Red for Women campaign has improved awareness of cardiovascular disease ( CVD ) among adult women aged 25 years and older. Little is known about awareness among younger women. Methods and Results We assessed awareness of CVD and prevention efforts among 331 young women aged 15 to 24 years using the American Heart Association National Women's Health Study survey. Read More

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http://dx.doi.org/10.1161/JAHA.118.011195DOI Listing
March 2019
2 Reads

Determinants of In-Hospital Mortality After Percutaneous Coronary Intervention: A Machine Learning Approach.

J Am Heart Assoc 2019 Mar;8(5):e011160

3 Division of Cardiology Department of Medicine Weill Cornell Medicine New York NY.

Background The ability to accurately predict the occurrence of in-hospital death after percutaneous coronary intervention is important for clinical decision-making. We sought to utilize the New York Percutaneous Coronary Intervention Reporting System in order to elucidate the determinants of in-hospital mortality in patients undergoing percutaneous coronary intervention across New York State. Methods and Results We examined 479 804 patients undergoing percutaneous coronary intervention between 2004 and 2012, utilizing traditional and advanced machine learning algorithms to determine the most significant predictors of in-hospital mortality. Read More

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http://dx.doi.org/10.1161/JAHA.118.011160DOI Listing
March 2019
2 Reads

Effectiveness and Safety of Non-Vitamin K Antagonist Oral Anticoagulant and Warfarin in Cirrhotic Patients With Nonvalvular Atrial Fibrillation.

J Am Heart Assoc 2019 Mar;8(5):e011112

3 Center for Big Data Analytics and Statistics Chang Gung Memorial Hospital Linkou, Taoyuan Taiwan.

Background Liver cirrhotic patients with nonvalvular atrial fibrillation have been excluded from randomized clinical studies regarding oral anticoagulants for stroke prevention. Whether non-vitamin K antagonist oral anticoagulants ( NOAC s) are superior to warfarin for these patients remains unclear. Methods and Results This nationwide retrospective cohort study, with data collected from the Taiwan National Health Insurance Research Database, enrolled 2428 liver cirrhotic patients with nonvalvular atrial fibrillation taking apixaban (n=171), dabigatran (n=535), rivaroxaban (n=732), or warfarin (n=990) from June 1, 2012, to December 31, 2016. Read More

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http://dx.doi.org/10.1161/JAHA.118.011112DOI Listing
March 2019
9 Reads

Anticoagulation for Atrial Fibrillation in Cirrhosis of the Liver: Are Low-Dose Non-Vitamin K Oral Anticoagulants a Reasonable Alternative to Warfarin?

J Am Heart Assoc 2019 Mar;8(5):e012102

1 Centre for Heart Rhythm Disorders University of Adelaide and Royal Adelaide Hospital Adelaide Australia.

See Article by Lee et al. Read More

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http://dx.doi.org/10.1161/JAHA.119.012102DOI Listing
March 2019
1 Read

Improving the Diagnosis of Culprit Left Circumflex Occlusion With Acute Myocardial Infarction in Patients With a Nondiagnostic 12-Lead ECG at Presentation: A Retrospective Cohort Study.

J Am Heart Assoc 2019 Mar;8(5):e011029

1 Heart Centre Royal Victoria Hospital Belfast United Kingdom.

Background Left circumflex culprit is often missed by the standard 12-lead ECG . Extended lead systems (body surface potential map [ BSPM ]) should improve the diagnosis of culprit left circumflex stenosis with myocardial infarction. Methods and Results Retrospective analysis of a hospital research registry (August 2000-August 2010) comprising consecutive patients with (1) ischemic-type chest pain at rest; (2) 12-lead ECG and 80-lead BSPM at first medical contact; and (3) cardiac troponin-T 12 hours after symptom onset and/or creatine kinase MB fraction, were undertaken. Read More

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http://dx.doi.org/10.1161/JAHA.118.011029DOI Listing
March 2019
6 Reads

Thinking Machines and Risk Assessment: On the Path to Precision Medicine.

J Am Heart Assoc 2019 Mar;8(5):e011969

2 Applied Innovation Group Christiana Care Health System Wilmington DE.

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http://dx.doi.org/10.1161/JAHA.119.011969DOI Listing
March 2019
1 Read

Nocturia as an Unrecognized Symptom of Uncontrolled Hypertension in Black Men Aged 35 to 49 Years.

J Am Heart Assoc 2019 Mar;8(5):e010794

2 Department of Biomathematics David Geffen School of Medicine at UCLA Los Angeles CA.

Background Hypertension is assumed to be asymptomatic. Yet, clinically significant nocturia (≥2 nightly voids) constitutes a putative symptom of uncontrolled hypertension. Black men with hypertension may be prone to nocturia because of blunted nocturnal blood pressure ( BP ) dipping, diuretic drug use for hypertension, and comorbidity that predisposes to nocturia. Read More

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http://dx.doi.org/10.1161/JAHA.118.010794DOI Listing
March 2019
1 Read

Detection of Left Ventricular Hypertrophy Using Bayesian Additive Regression Trees: The MESA.

J Am Heart Assoc 2019 Mar;8(5):e009959

9 Epidemiological Cardiology Research Center Department of Epidemiology and Prevention Wake Forest School of Medicine Winston Salem NC.

Background We developed a new left ventricular hypertrophy ( LVH ) criterion using a machine-learning technique called Bayesian Additive Regression Trees ( BART ). Methods and Results This analysis included 4714 participants from MESA (Multi-Ethnic Study of Atherosclerosis) free of clinically apparent cardiovascular disease at enrollment. We used BART to predict LV mass from ECG and participant characteristics using cardiac magnetic resonance imaging as the standard. Read More

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http://dx.doi.org/10.1161/JAHA.118.009959DOI Listing
March 2019
1 Read

Abnormal Microstructural Development of the Cerebral Cortex in Neonates With Congenital Heart Disease Is Associated With Impaired Cerebral Oxygen Delivery.

J Am Heart Assoc 2019 Mar;8(5):e009893

1 Centre for the Developing Brain School of Biomedical Engineering and Imaging Sciences King's College London St Thomas' Hospital London United Kingdom.

Background Abnormal macrostructural development of the cerebral cortex has been associated with hypoxia in infants with congenital heart disease ( CHD ). Animal studies have suggested that hypoxia results in cortical dysmaturation at the cellular level. New magnetic resonance imaging techniques offer the potential to investigate the relationship between cerebral oxygen delivery and cortical microstructural development in newborn infants with CHD . Read More

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http://dx.doi.org/10.1161/JAHA.118.009893DOI Listing
March 2019
2 Reads

High-Sensitivity Cardiac Troponin I Improves Cardiovascular Risk Prediction in Older Men: HIMS (The Health in Men Study).

J Am Heart Assoc 2019 Mar;8(5):e011818

1 Medical School University of Western Australia Perth Australia.

Background The Framingham Risk Score estimates the 10-year risk of cardiovascular events. However, it performs poorly in older adults. We evaluated the incremental benefit of adding high-sensitivity cardiac troponin I (hs-cTnI) to the Framingham Risk Score. Read More

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http://dx.doi.org/10.1161/JAHA.118.011818DOI Listing
March 2019
2 Reads

Influence of 2-Methoxyestradiol and Sex on Hypoxia-Induced Pulmonary Hypertension and Hypoxia-Inducible Factor-1-α.

J Am Heart Assoc 2019 Mar;8(5):e011628

1 Research Institute of Cardiovascular and Medical Sciences College of Medical, Veterinary and Life Sciences University of Glasgow United Kingdom.

Background Women are at greater risk of developing pulmonary arterial hypertension, with estrogen and its downstream metabolites playing a potential role in the pathogenesis of the disease. Hypoxia-inducible factor-1-α (HIF 1α) is a pro-proliferative mediator and may be involved in the development of human pulmonary arterial hypertension . The estrogen metabolite 2-methoxyestradiol (2 ME 2) has antiproliferative properties and is also an inhibitor of HIF 1α. Read More

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http://dx.doi.org/10.1161/JAHA.118.011628DOI Listing
March 2019
2 Reads

Native Coronary Collateral Microcirculation Reserve in Rat Hearts.

J Am Heart Assoc 2019 Mar;8(5):e011220

1 Department of Thoracic Cardiovascular Surgery Affiliated Hospital of Xuzhou Medical University Xuzhou China.

Background We occasionally noticed that native collateral blood flow showed a recessive trend in the early stages of acute myocardial infarction in rats, which greatly interferes with the accurate assessment of native collateral circulation levels. Here, we sought to recognize the coronary collateral circulation system in depth, especially the microcirculation part, on this basis. Methods and Results In this study, we detected native collateral flow with positron emission tomography perfusion imaging in rats and found that the native flow is relatively abundant when it is initially recruited. Read More

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http://dx.doi.org/10.1161/JAHA.118.011220DOI Listing
March 2019
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Catheter Ablation of Ventricular Tachycardia in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: A Sequential Approach.

J Am Heart Assoc 2019 Mar;8(5):e010365

1 Department of Cardiology Asklepios Klinik St. Georg Hamburg Germany.

Background It has been suggested that endocardial and epicardial ablation of ventricular tachycardia ( VT ) improves outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia. We investigated our sequential approach for VT ablation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia in a single center. Methods and Results We included 47 patients (44±16 years) with definite (81%) or borderline (19%) arrhythmogenic right ventricular cardiomyopathy/dysplasia between 1998 and 2016. Read More

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http://dx.doi.org/10.1161/JAHA.118.010365DOI Listing
March 2019
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Rivaroxaban in Acute Coronary Syndromes: We Have a Compass and an Atlas, But Where Are We Headed?

J Am Heart Assoc 2019 Mar;8(5):e012014

1 Division of Cardiology Department of Medicine and Duke Clinical Research Institute Duke University Medical Center Durham NC.

See Article by Gibson et al. Read More

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http://dx.doi.org/10.1161/JAHA.119.012014DOI Listing
March 2019
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Influence of Sex on Relationship Between Total Anatomical and Physiologic Disease Burdens and Their Prognostic Implications in Patients With Coronary Artery Disease.

J Am Heart Assoc 2019 Mar;8(5):e011002

15 Department of Cardiology Wakayama Medical University Wakayama Japan.

Background Total atherosclerosis disease burden is associated with clinical outcomes in patients with coronary artery disease. However, the influence of sex on the relationship between total anatomical and physiologic disease burdens and their prognostic implications have not been well defined. Methods and Results A total of 1136 patients who underwent fractional flow reserve (FFR) measurement in all 3 major coronary arteries were included in this study. Read More

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http://dx.doi.org/10.1161/JAHA.118.011002DOI Listing
March 2019
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Impact of Mitral Regurgitation Severity and Cause on Effort Tolerance-Integrated Stress Myocardial Perfusion Imaging and Echocardiographic Assessment of Patients With Known or Suspected Coronary Artery Disease Undergoing Exercise Treadmill Testing.

J Am Heart Assoc 2019 Mar;8(5):e010974

1 Department of Medicine Weill Cornell Medical College New York NY.

Background Mitral regurgitation ( MR ) has the potential to impede exercise capacity; it is uncertain whether this is because of regurgitation itself or the underlying cause of valvular insufficiency. Methods and Results The population comprised 3267 patients who underwent exercise treadmill myocardial perfusion imaging and transthoracic echocardiography within 6±8 days. MR was present in 28%, including 176 patients (5%) with moderate or greater MR . Read More

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http://dx.doi.org/10.1161/JAHA.118.010974DOI Listing
March 2019
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Ultrastructural Changes of the Right Ventricular Myocytes in Pulmonary Arterial Hypertension.

J Am Heart Assoc 2019 Mar;8(5):e011227

1 Department of Pharmacology and Physiology Georgetown University Medical Center Washington DC.

Background Pulmonary arterial hypertension ( PAH ) is a serious disease without cure. Elevated pulmonary vascular resistance puts strain on the right ventricle ( RV ) and patients die of RV failure. Subjecting Sprague-Dawley rats to SU 5416 injection and hypoxia promotes severe PAH with pulmonary vascular lesions similar to human disease and has been well utilized to investigate pulmonary vascular pathology. Read More

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http://dx.doi.org/10.1161/JAHA.118.011227DOI Listing
March 2019
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DASH Dietary Pattern, Mediation by Mineral Intakes, and the Risk of Coronary Artery Disease and Stroke Mortality.

J Am Heart Assoc 2019 Mar;8(5):e011054

3 Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore.

Background The association of the Dietary Approaches to Stop Hypertension ( DASH ) dietary pattern with stroke and coronary artery disease ( CAD ) mortality has not been evaluated in Asian populations, and the role of mineral intakes as potential mediators is not clear. Methods and Results We used data from 57 078 participants of the Singapore Chinese Health Study aged 45 to 74 years at baseline (1993-1998). Information on usual diet was collected by a validated 165-item food frequency questionnaire at recruitment, and mortality information was obtained via registry linkage up to December 31, 2014. Read More

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March 2019
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Association Between Depression and Outcomes in Chinese Patients With Myocardial Infarction and Nonobstructive Coronary Arteries.

J Am Heart Assoc 2019 Mar;8(5):e011180

3 Department of Nephrology First Affiliated Hospital of Jiaxing University Jiaxing Zhejiang China.

Background Myocardial infarction with nonobstructive coronary arteries ( MINOCA ) occurs in ≈10% of all patients with myocardial infarction. Studies on effects of depression on MINOCA outcomes are lacking. Therefore, the aim of this study was to examine the association of depression with clinical outcomes in Chinese patients with MINOCA . Read More

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March 2019
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Development and Validation of a Novel Risk Score for In-Hospital Major Bleeding in Acute Myocardial Infarction:-The SWEDEHEART Score.

J Am Heart Assoc 2019 Mar;8(5):e012157

1 Department of Clinical Sciences Karolinska Institutet Danderyd Sweden.

Background Bleeding risk stratification in acute coronary syndrome is of highest clinical interest but current risk scores have limitations. We sought to develop and validate a new in-hospital bleeding risk score for patients with acute myocardial infarction. Methods and Results From the nationwide SWEDEHEART (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies) register, 97,597 patients with acute myocardial infarction enrolled from 2009 until 2014 were selected. Read More

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http://dx.doi.org/10.1161/JAHA.119.012157DOI Listing
March 2019
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Outcomes of Anticoagulation Therapy in Adults With Tetralogy of Fallot.

J Am Heart Assoc 2019 Mar;8(5):e011474

1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Available outcomes data for anticoagulation therapy in adults with congenital heart disease ( CHD ) provide assessment of global risk of this therapy for CHD patients (a heterogeneous population), but the risk of complications for the different CHD diagnoses is unknown. The purpose of the study was to describe the indications for anticoagulation, and the incidence and risk factors for major bleeding complication in adults with tetralogy of Fallot. Methods and Results We queried Mayo Adult Congenital Heart Disease (MACHD) database for tetralogy of Fallot patients (aged ≥18 years) that received anticoagulation, 1990-2017. Read More

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http://dx.doi.org/10.1161/JAHA.118.011474DOI Listing
March 2019
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Highlights From the American Heart Association's Joint Hypertension 2018 Scientific Sessions.

J Am Heart Assoc 2019 Mar;8(5):e011176

1 Department of Pharmacology and Toxicology Faculty of Medicine American University of Beirut Lebanon.

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http://dx.doi.org/10.1161/JAHA.118.011176DOI Listing
March 2019
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