25,242 results match your criteria Journal of the American College of Cardiology[Journal]


RESPONSE: Establishing a Strong Foundation for Lifelong Learning.

Authors:
Sunil V Rao

J Am Coll Cardiol 2019 Feb;73(7):871-872

The Duke Clinical Research Institute, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.01.008DOI Listing
February 2019

Rethinking the Modern Cardiology Morbidity and Mortality Conference: Harmonizing Quality Improvement and Education.

J Am Coll Cardiol 2019 Feb;73(7):868-872

Division of Cardiology, Department of Internal Medicine, University of Texas Southwest Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jacc.2019.01.007DOI Listing
February 2019

Editor-in-Chief's Top Picks From 2018.

Authors:
Valentin Fuster

J Am Coll Cardiol 2019 Feb;73(7):826-867

Each week, I record audio summaries for every article in JACC, as well as an issue summary. Although this process is quite time-consuming, I have become familiar with every paper that we publish. Thus, I have personally selected the top 100 papers (both Original Investigations and Review Articles) from 15 distinct specialties each year. Read More

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http://dx.doi.org/10.1016/j.jacc.2019.01.004DOI Listing
February 2019
1 Read

Bad Atrioventricular Valve, Bad Fontan: Stop Creating Bad Fontans.

J Am Coll Cardiol 2019 Feb;73(7):823-825

Division of Pediatric Cardiology and Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.jacc.2018.12.026DOI Listing
February 2019

Atrioventricular Valve Failure in Fontan Palliation.

J Am Coll Cardiol 2019 Feb;73(7):810-822

Department of Cardiac Surgery, Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia; Heart Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. Electronic address:

Background: Atrioventricular valve failure (moderate or greater regurgitation, or valve operation) is a risk factor for adverse outcomes in patients undergoing Fontan palliation.

Objectives: This study determined the incidence of atrioventricular valve failure and its clinical impact on patients undergoing Fontan palliation.

Methods: A retrospective cohort longitudinal study was conducted using patient data extracted from an existing bi-national, population-based registry. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.12.025DOI Listing
February 2019

Is Sacubitril/Valsartan Antifibrotic?

J Am Coll Cardiol 2019 Feb;73(7):807-809

Université de Lorraine, Inserm, Centre d'Investigations Cliniques-Plurithématique 14-33, and Inserm U1116, CHRU, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

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http://dx.doi.org/10.1016/j.jacc.2018.11.041DOI Listing
February 2019

Effects of Sacubitril/Valsartan on Biomarkers of Extracellular Matrix Regulation in Patients With HFrEF.

J Am Coll Cardiol 2019 Feb;73(7):795-806

Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.

Background: Myocardial fibrosis is an important pathophysiological mechanism underlying the development of heart failure (HF). Given the biochemical targets of sacubitril/valsartan, we hypothesized that circulating biomarkers reflecting the mechanisms that determine extracellular matrix (ECM) homeostasis, including collagen synthesis, processing, and degradation, are altered by sacubitril/valsartan in comparison to enalapril.

Objectives: The purpose of this study was to examine the effects of sacubitril/valsartan on biomarkers of ECM homeostasis and the association between the rate of primary composite outcome (cardiovascular death or HF hospitalization) and these biomarkers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183950
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http://dx.doi.org/10.1016/j.jacc.2018.11.042DOI Listing
February 2019
21 Reads

Cardiac Magnetic Resonance and Cardio-Oncology: Does T Signal the End of Anthracycline Cardiotoxicity?

J Am Coll Cardiol 2019 Feb;73(7):792-794

Cardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1016/j.jacc.2018.11.045DOI Listing
February 2019

Serial Magnetic Resonance Imaging to Identify Early Stages of Anthracycline-Induced Cardiotoxicity.

J Am Coll Cardiol 2019 Feb;73(7):779-791

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Cardiology Department, IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain. Electronic address:

Background: Anthracycline-induced cardiotoxicity is a major clinical problem, and early cardiotoxicity markers are needed.

Objectives: The purpose of this study was to identify early doxorubicin-induced cardiotoxicity by serial multiparametric cardiac magnetic resonance (CMR) and its pathological correlates in a large animal model.

Methods: Twenty pigs were included. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.046DOI Listing
February 2019

Anticoagulation, the Unknown of the Antithrombotic Equation After Stenting of an Acute Coronary Syndrome.

J Am Coll Cardiol 2019 Feb;73(7):775-778

Division of Cardiology, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida.

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http://dx.doi.org/10.1016/j.jacc.2018.12.022DOI Listing
February 2019

Post-Procedural Bivalirudin Infusion at Full or Low Regimen in Patients With Acute Coronary Syndrome.

J Am Coll Cardiol 2019 Feb;73(7):758-774

Department of Cardiology, Bern University Hospital, Bern, Switzerland. Electronic address:

Background: The value of prolonged bivalirudin infusion after percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) patients with or without ST-segment elevation remains unclear.

Objectives: The purpose of this study was to assess efficacy and safety of a full or low post-PCI bivalirudin regimen in ACS patients with or without ST-segment elevation.

Methods: The MATRIX program assigned bivalirudin to patients without or with a post-PCI infusion at either a full (1. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.12.023DOI Listing
February 2019

Optimizing DAPT Duration in High-Risk Patients After Coronary Stent Implantation: Bleeding Risk Takes It All.

J Am Coll Cardiol 2019 Feb;73(7):755-757

Intensive Cardiac Care Unit and Cardiology Department, Centre Hospitalier Regional Universitaire de Tours & Tours University, Loire Valley Cardiovascular Collaboration, Tours, France.

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http://dx.doi.org/10.1016/j.jacc.2018.11.047DOI Listing
February 2019

Dual Antiplatelet Therapy Duration Based on Ischemic and Bleeding Risks After Coronary Stenting.

J Am Coll Cardiol 2019 Feb;73(7):741-754

Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland. Electronic address:

Background: Complex percutaneous coronary intervention (PCI) is associated with higher ischemic risk, which can be mitigated by long-term dual antiplatelet therapy (DAPT). However, concomitant high bleeding risk (HBR) may be present, making it unclear whether short- or long-term DAPT should be prioritized.

Objectives: This study investigated the effects of ischemic (by PCI complexity) and bleeding (by PRECISE-DAPT [PREdicting bleeding Complications in patients undergoing stent Implantation and SubsequEnt Dual AntiPlatelet Therapy] score) risks on clinical outcomes and on the impact of DAPT duration after coronary stenting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183954
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http://dx.doi.org/10.1016/j.jacc.2018.11.048DOI Listing
February 2019
1 Read

Financial Hardship From Medical Bills Among Nonelderly U.S. Adults With Atherosclerotic Cardiovascular Disease.

J Am Coll Cardiol 2019 Feb;73(6):727-732

Center for Outcomes Research and Evaluation, Yale New Haven Health, New Haven, Connecticut; Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.12.004DOI Listing
February 2019

Diagnosis and Treatment of Lyme Carditis: JACC Review Topic of the Week.

J Am Coll Cardiol 2019 Feb;73(6):717-726

Department of Cardiology, Queen's University, Kingston, Ontario, Canada. Electronic address:

The incidence of Lyme disease, a tick-borne bacterial infection, is dramatically increasing in North America. The diagnosis of Lyme carditis (LC), an early disseminated manifestation of Lyme disease, has important implications for patient management and preventing further extracutaneous complications. High-degree atrioventricular block is the most common presentation of LC, and usually resolves with antibiotic therapy. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.035DOI Listing
February 2019
1 Read

Venoarterial ECMO for Adults: JACC Scientific Expert Panel.

J Am Coll Cardiol 2019 Feb;73(6):698-716

Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York.

Venoarterial extracorporeal membrane oxygenation (ECMO) is a rescue therapy that can stabilize patients with hemodynamic compromise, with or without respiratory failure, for days or weeks. In cardiology, the main indications for ECMO include cardiac arrest, cardiogenic shock, post-cardiotomy shock, refractory ventricular tachycardia, and acute management of complications of invasive procedures. The fundamental premise underlying ECMO is that it is a bridge-to recovery, to a more durable bridge, to definitive treatment, or to decision. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.038DOI Listing
February 2019
1 Read

The Feminine Face of Ischemic Heart Disease: Challenges and Opportunities.

Authors:
Nanette K Wenger

J Am Coll Cardiol 2019 Feb;73(6):694-697

Division of Cardiology, Emory University School of Medicine, Emory Heart and Vascular Center, and Emory Women's Heart Center, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.12.011DOI Listing
February 2019

Impact of Abnormal Coronary Reactivity on Long-Term Clinical Outcomes in Women.

J Am Coll Cardiol 2019 Feb;73(6):684-693

Division of Cardiovascular Disease, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Currently as many as one-half of women with suspected myocardial ischemia have no obstructive coronary artery disease (CAD), and abnormal coronary reactivity (CR) is commonly found.

Objectives: The authors prospectively investigated CR and longer-term adverse cardiovascular outcomes in women with and with no obstructive CAD in the National Heart, Lung, and Blood Institute-sponsored WISE (Women's Ischemia Syndrome Evaluation) study.

Methods: Women (n = 224) with signs and symptoms of ischemia underwent CR testing. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383781PMC
February 2019
1 Read

Endovascular Treatment of the Superficial Femoral Artery: When Nothing Is Actually Quite Something.

J Am Coll Cardiol 2019 Feb;73(6):680-683

Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.12.009DOI Listing
February 2019

Drug-Eluting Stent Versus Drug-Coated Balloon Revascularization in Patients With Femoropopliteal Arterial Disease.

J Am Coll Cardiol 2019 Feb;73(6):667-679

Division of Angiology, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Leipzig, Germany. Electronic address:

Background: Randomized trials of drug-eluting stents (DES) and drug-coated balloons (DCB) for femoropopliteal interventions reported superior patency rates for both strategies compared to standard balloon angioplasty. To date, head-to-head comparisons are missing.

Objectives: The authors sought to compare DES versus DCB for femoropopliteal lesions through 36 months. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.039DOI Listing
February 2019

Unloading Is Not the Only Question in Cardiogenic Shock.

J Am Coll Cardiol 2019 Feb;73(6):663-666

Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2018.11.036DOI Listing
February 2019
1 Read

Left Ventricular Unloading During Extracorporeal Membrane Oxygenation in Patients With Cardiogenic Shock.

J Am Coll Cardiol 2019 Feb;73(6):654-662

University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:

Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a widely used form of mechanical circulatory support in patients with refractory cardiogenic shock. A common drawback of this modality is a resultant increase in left ventricular afterload.

Objectives: The purpose of this meta-analysis was to examine the efficacy and safety of left ventricular unloading strategies during VA-ECMO in adult patients with cardiogenic shock. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.085DOI Listing
February 2019
1 Read

TEVAR Versus Open Surgery in Medicare Patients With Descending Thoracic Aneurysms: And the Winner Is?

J Am Coll Cardiol 2019 Feb;73(6):652-653

New Mexico Heart Institute, Albuquerque, New Mexico; University of New Mexico, Albuquerque, New Mexico.

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http://dx.doi.org/10.1016/j.jacc.2018.11.037DOI Listing
February 2019

Endovascular Versus Open Repair of Intact Descending Thoracic Aortic Aneurysms.

J Am Coll Cardiol 2019 Feb;73(6):643-651

Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California. Electronic address:

Background: For the management of descending thoracic aortic aneurysms, recent evidence has suggested that outcomes of open surgical repair may surpass thoracic endovascular aortic repair (TEVAR) in as early as 2 years.

Objectives: The purpose of this study was to evaluate the comparative effectiveness of TEVAR and open surgical repair in the treatment of intact descending thoracic aortic aneurysms.

Methods: Using the Medicare database, a retrospective study using regression discontinuity design and propensity score matching was performed on patients with intact descending thoracic aortic aneurysms who underwent TEVAR or open surgical repair between 1999 and 2010 with follow-up through 2014. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.086DOI Listing
February 2019
1 Read

Academic Advancement in the Current Era: Integrating and Empowering Clinician Educators.

J Am Coll Cardiol 2019 Feb;73(5):620-623

Division of Cardiology, Department of Medicine, National Jewish Health, Denver, Colorado. Electronic address: https://twitter.com/heartcuredoc.

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http://dx.doi.org/10.1016/j.jacc.2018.11.032DOI Listing
February 2019

Atrial Fibrillation and Cognitive Function: JACC Review Topic of the Week.

J Am Coll Cardiol 2019 Feb;73(5):612-619

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Numerous vascular risk factors and vascular diseases contribute to cognitive impairment and dementia. Many studies and registries show an association of atrial fibrillation (AF) with cognitive impairment, cognitive decline, and dementia. This is true for vascular dementia and Alzheimer's disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183934
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http://dx.doi.org/10.1016/j.jacc.2018.10.077DOI Listing
February 2019
4 Reads

Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review.

J Am Coll Cardiol 2019 Feb;73(5):602-611

Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, North Carolina; Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, Durham, North Carolina. Electronic address:

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of HF, affecting over 3 million adults in the United States alone. HFpEF is a heterogenous syndrome. One important phenotype may be related to comorbid conditions, including diabetes mellitus (DM). Read More

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http://dx.doi.org/10.1016/j.jacc.2018.11.033DOI Listing
February 2019
16.503 Impact Factor

Cardiac Amyloidosis and the Risks of Cardioversion.

J Am Coll Cardiol 2019 Feb;73(5):598-601

Cardiology Department, Marshfield Clinic, Marshfield, Wisconsin; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.10.080DOI Listing
February 2019

Direct Current Cardioversion of Atrial Arrhythmias in Adults With Cardiac Amyloidosis.

J Am Coll Cardiol 2019 Feb;73(5):589-597

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Arrhythmias, conduction abnormalities, and intracardiac thrombus are common in patients with cardiac amyloidosis (CA). Outcomes of direct-current cardioversion (DCCV) for atrial arrhythmias in patients with CA are unknown.

Objectives: This study sought to examine DCCV procedural outcomes in patients with CA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183939
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http://dx.doi.org/10.1016/j.jacc.2018.10.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378685PMC
February 2019
3 Reads
16.503 Impact Factor

Clues to Diagnose Myocardial Infarction in the Young: No Longer a Needle in the Haystack.

Authors:
Basmah Safdar

J Am Coll Cardiol 2019 Feb;73(5):585-588

Department of Emergency Medicine, Yale University, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.11.034DOI Listing
February 2019
1 Read

Modifiable Risk Factors in Young Adults With First Myocardial Infarction.

J Am Coll Cardiol 2019 Feb;73(5):573-584

Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, New York.

Background: Modifiable risk factors (RFs) play an important role in the development and prognosis of acute myocardial infarction (AMI).

Objectives: This study sought to study the prevalence rates of modifiable RFs during a first AMI, sex/race differences, and temporal trends in U.S. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.084DOI Listing
February 2019

Infective Endocarditis in Injection Drug Users: A Recurrent Disease.

J Am Coll Cardiol 2019 Feb;73(5):571-572

Aix-Marseille Université, Institut de Recherche pour le Developpement, Assistance Publique Hopitaux de Marseille, Microbes Evolution Phylogeny and Infection, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.

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http://dx.doi.org/10.1016/j.jacc.2018.10.081DOI Listing
February 2019
1 Read

Clinical Outcomes of Infective Endocarditis in Injection Drug Users.

J Am Coll Cardiol 2019 Feb;73(5):559-570

Cardiovascular Outcomes Research Laboratories, Division of Cardiac Surgery, David Geffen School of Medicine, University of California, Los Angeles, California. Electronic address:

Background: Rising rates of hospitalization for infective endocarditis (IE) have been increasingly tied to rising injection drug use (IDU) associated with the opioid epidemic.

Objectives: This study analyzed recent trends in IDU-IE hospitalization and characterized outcomes and readmissions for IDU-IE patients.

Methods: The authors evaluated the National Readmissions Database (NRD) for IE cases between January 2010 and September 2015. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.082DOI Listing
February 2019
2 Reads

The Long Quest for the Holy Grail in Transcatheter Aortic Bioprosthesis: Durability and Long-Term Performance.

J Am Coll Cardiol 2019 Feb;73(5):554-558

University of Liège Hospital, GIGA Cardiovascular Sciences, Departments of Cardiology and Cardiovascular Surgery, Heart Valve Clinic, CHU Sart Tilman, Liège, Belgium.

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http://dx.doi.org/10.1016/j.jacc.2018.11.043DOI Listing
February 2019

Durability of Transcatheter and Surgical Bioprosthetic Aortic Valves in Patients at Lower Surgical Risk.

J Am Coll Cardiol 2019 Feb;73(5):546-553

Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Transcatheter aortic valve replacement (TAVR) is an alternative to surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis and intermediate or high surgical risk.

Objectives: The aim of this study was to compare the durability of transcatheter and surgical bioprosthetic aortic valves using standardized criteria.

Methods: In the NOTION (Nordic Aortic Valve Intervention) trial, all-comer patients with severe aortic stenosis and lower surgical risk for mortality were randomized 1:1 to TAVR (n = 139) or SAVR (n = 135). Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.083DOI Listing
February 2019
1 Read

Long-Term Durability of Transcatheter Aortic Valve Prostheses.

J Am Coll Cardiol 2019 Feb;73(5):537-545

Department of Cardiology, Royal Sussex County Hospital, Brighton, United Kingdom.

Background: Very little is known about long-term valve durability after transcatheter aortic valve replacement (TAVR).

Objectives: This study sought to evaluate the incidence of structural valve degeneration (SVD) 5 to 10 years post-procedure.

Methods: Demographic, procedural, and in-hospital outcome data on patients who underwent TAVR from 2007 to 2011 were obtained from the U. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.078DOI Listing
February 2019
3 Reads