6,423 results match your criteria Journal of the American Academy of Child and Adolescent Psychiatry[Journal]


Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation.

J Am Acad Child Adolesc Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

University of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington.

Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype.

Method: Age 14 adolescents from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties ("dysregulated"; n=233) who were compared to a matched sample from a low symptom class (controls, n=233). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193026
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http://dx.doi.org/10.1016/j.jaac.2019.01.021DOI Listing
April 2019
1 Read

Meta-Analysis: 13-Year Follow-Up of Psychotherapy Effects on Youth Depression.

J Am Acad Child Adolesc Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

Objective: Youth depression is a debilitating condition that constitutes a major public health concern. A 2006 meta-analysis found modest benefits for psychotherapy vs. control. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.04.002DOI Listing

Editorial: What Cures One Can Kill Another.

J Am Acad Child Adolesc Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Denver Health and Hospital Authority, University of Colorado Anschutz Medical Campus, Aurora. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193026
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http://dx.doi.org/10.1016/j.jaac.2018.12.014DOI Listing
April 2019
1 Read

Editorial: Prescription for Addiction.

Authors:
Paula Riggs

J Am Acad Child Adolesc Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

University of Colorado School of Medicine, Denver. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.030DOI Listing

Proband and Familial Autoimmune Diseases Are Associated With Proband Diagnosis of Autism Spectrum Disorders.

J Am Acad Child Adolesc Psychiatry 2019 Feb 16. Epub 2019 Feb 16.

Columbia University Irving Medical Center, New York, NY; New York State Psychiatric Institute, New York, NY.

Objective: There is evidence that parental autoimmune diseases (ADs) are associated with autism spectrum disorders (ASD) in offspring. The association between offspring ASD and ADs diagnosed in siblings and probands remains less clear. We examined whether proband and familial diagnoses of ADs were associated with increased odds of ASD in probands. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.444DOI Listing
February 2019

Validation of the UCLA PTSD Reaction Index for DSM-5: A Developmentally-Informed Assessment Tool for Youth.

J Am Acad Child Adolesc Psychiatry 2019 Apr 3. Epub 2019 Apr 3.

University of California, Los Angeles (UCLA); UCLA/Duke University National Center for Child Traumatic Stress, Los Angeles, CA, and Durham, NC.

Objective: To describe the test construction procedure and evaluate the internal consistency, criterion-referenced validity, and diagnostic accuracy of the Child/Adolescent Self-Report Version of the UCLA PTSD Reaction Index for DSM-5 (RI-5) across two independent samples.

Method: Study 1 examined the clarity, developmental appropriateness, acceptability of individual RI-5 items, and the internal consistency and criterion-referenced validity of the full test. The Study 1 sample included 486 youth recruited from two major U. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.10.019DOI Listing
April 2019
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Symptom Profiles Specific to Trauma in a Child Inpatient Unit.

J Am Acad Child Adolesc Psychiatry 2019 Apr 3. Epub 2019 Apr 3.

The Reach Institute, New York, NY.

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http://dx.doi.org/10.1016/j.jaac.2019.03.024DOI Listing

VitalSign: Screening, Diagnosis, and Treatment of Depression for Adolescents Presenting to Pediatric Primary and Specialty Care Settings.

J Am Acad Child Adolesc Psychiatry 2019 Apr 3. Epub 2019 Apr 3.

University of Texas Southwestern Medical Center Dallas.

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http://dx.doi.org/10.1016/j.jaac.2019.01.019DOI Listing
April 2019
3 Reads

Randomized Trial of a Computer-Assisted Intervention for Children With Autism in Schools.

J Am Acad Child Adolesc Psychiatry 2019 Apr 3. Epub 2019 Apr 3.

Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Objective: Computer-assisted interventions (CAI) are popular for educating children with autism, but their effectiveness is not well-established. We evaluated the effectiveness of one CAI designed to improve children's language, cognitive, and academic skills, TeachTown: Basics, in a large urban school district.

Method: Teachers (n = 59) in autism support classrooms and their consented students in kindergarten through second grade (n = 154) were randomized to TeachTown: Basics or waitlist control. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.03.029DOI Listing

Did Bullying Victimization Decrease After Nationwide School-Based Anti-Bullying Program? A Time-Trend Study.

J Am Acad Child Adolesc Psychiatry 2019 Apr 2. Epub 2019 Apr 2.

Faculty of Medicine, University of Turku, Finland; Turku University Hospital, Turku, Finland.

Objective: We assessed changes in traditional and cyberbullying victimization, and their associations with mental health, before and after the introduction of a nationwide anti-bullying program in Finnish schools in 2009.

Method: This time-trend assessment comprised two methodologically identical cross-sectional survey studies, with 2,061 adolescents in 2008 (response rate 90.2%) and 1,936 in 2014 (91. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.03.023DOI Listing

Prognostic Implications for Adolescents With Depression Who Drop Out of Psychological Treatment During a Randomized Controlled Trial.

J Am Acad Child Adolesc Psychiatry 2019 Apr 1. Epub 2019 Apr 1.

Child Attachment and Psychological Therapies Research Unit (ChAPTRe), Anna Freud National Centre for Children and Families, London, UK; University College London, UK.

Objective: High therapy dropout rates among adolescents have been reported, but little is known about whether dropout is associated with poor outcomes. This study aimed to examine clinical outcomes in adolescents with depression who dropped out of psychological therapy and to determine if this varied by treatment type.

Method: Data was drawn from the IMPACT study; a randomised controlled trial, comparing a Brief Psychosocial Intervention, Cognitive-Behavioral Therapy and Short-Term Psychoanalytic Psychotherapy in the treatment of adolescent major depression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193021
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http://dx.doi.org/10.1016/j.jaac.2018.11.019DOI Listing
April 2019
4 Reads

Editorial: Understanding the Child at Risk for Substance Use Disorders: Neuroimaging Addiction Risk.

J Am Acad Child Adolesc Psychiatry 2019 Mar 27. Epub 2019 Mar 27.

Indiana University School of Medicine, Indianapolis. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.018DOI Listing

Editorial: Making Use of What We Know: Medical Decision-Making and Antipsychotics.

Authors:
Gail A Edelsohn

J Am Acad Child Adolesc Psychiatry 2019 Mar 27. Epub 2019 Mar 27.

Community Care Behavioral Health Organization, University Pittsburgh Medical Center Insurance Division, PA. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.019DOI Listing
March 2019
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Sources of Nonmedical Prescription Drug Misuse Among US High School Seniors: Differences in Motives and Substance Use Behaviors.

J Am Acad Child Adolesc Psychiatry 2019 Mar 26. Epub 2019 Mar 26.

Center for the Study of Drugs, Alcohol, Smoking and Health, School of Nursing and Institute for Research on Women and Gender, University of Michigan, Ann Arbor.

Objective: To examine whether sources of nonmedical use of prescription drugs (NMUPD) involving anxiolytics, opioids, and stimulants were associated with sociodemographic characteristics, NMUPD characteristics (eg, frequency) and other substance use.

Method: Nationally representative samples of U.S. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.11.018DOI Listing
March 2019
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Saliva microRNA Differentiates Children With Autism From Peers With Typical and Atypical Development.

J Am Acad Child Adolesc Psychiatry 2019 Mar 26. Epub 2019 Mar 26.

State University of New York Upstate Medical University, Syracuse, NY.

Objective: Clinical diagnosis of autism spectrum disorder (ASD) relies on time-consuming subjective assessments. The primary purpose of this study was to investigate the utility of salivary microRNAs for differentiating children with ASD from peers with typical development (TD), and non-autism developmental delay (DD). The secondary purpose was to explore microRNA patterns among ASD phenotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193021
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http://dx.doi.org/10.1016/j.jaac.2019.03.017DOI Listing
March 2019
9 Reads

Home Visiting and Antenatal Depression Affect the Quality of Mother and Child Interactions in South Africa.

J Am Acad Child Adolesc Psychiatry 2019 Mar 26. Epub 2019 Mar 26.

Stellenbosch University, South Africa.

Objective: To examine whether maternal depressed mood at birth moderated the protective effect of a home-visiting intervention on the quality of caregiving for children growing up in a low- and middle-income country.

Method: Almost all pregnant mothers in 24 Cape Town neighborhoods were recruited into a cluster RCT matched by neighborhoods to either: the Philani home-visiting condition (HVC) or standard care (SC). At 3-years post-birth, the quality of mother-child interactions between HVC and SC mothers with and without antenatal depressed mood was assessed in a representative subset by rating videotaped observations of mother-child interactions on ten dimensions of caregiving. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.03.016DOI Listing

Mind the Gap: Considering Disparities in Implementing Measurement-Based Care.

J Am Acad Child Adolesc Psychiatry 2019 Apr;58(4):459-461

University of Washington School of Medicine, Seattle.

Synergistic advancements in evidence-based practice, implementation science, health care policy, and health information technology (HIT) have led to increasing efforts to broadly implement measurement-based care (MBC)-the systematic use of repeated outcome measures to monitor treatment progress and support clinical decision making-in psychiatric services. Much of this work has been done with adult populations, and more efforts are needed for MBC to gain traction in child and adolescent psychiatry. In this Letter to the Editor, we describe a quality improvement (QI) project that leveraged HIT to implement MBC in the child and adolescent psychiatry department of a regional pediatric tertiary-care center and report long-term (5-year) implementation outcomes (ie, adoption and penetration). Read More

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http://dx.doi.org/10.1016/j.jaac.2018.11.015DOI Listing
April 2019
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Editorial: Cognitive Behavior Therapy Versus Serotonin Reuptake Inhibitors for Pediatric Obsessive-Compulsive Disorder.

Authors:
Joseph Strayhorn

J Am Acad Child Adolesc Psychiatry 2019 Mar 20. Epub 2019 Mar 20.

private practice in Ithaca, NY, and is director of the Organization for Psychoeducational Tutoring, Inc. in Ithaca, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.015DOI Listing
March 2019
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Editorial: Autism Spectrum Disorder and Autoimmune Diseases: A Pathway in Common?

J Am Acad Child Adolesc Psychiatry 2019 Mar 19. Epub 2019 Mar 19.

School of Medicine, Universidade do Vale do Taquari (UNIVATES), Lajeado, Brazil, the National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Porto Alegre, Brazil; Translational Research Group in Autism Spectrum Disorders GETTEA, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.014DOI Listing
March 2019
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Longitudinal Links Between Callous-Unemotional Behaviors and Parenting in Early Childhood: A Genetically-Informed Design.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Objective: Most research on callous-unemotional behaviors (CU) and parenting does not focus on directions of effect, and work that does so has not been genetically-informed. The present study is the first to examine potential reciprocal effects between parenting and CU in a community sample of early childhood. Use of a twin sample also allows us to distinguish child-based genetic effects from environmentally-driven effects, which is necessary before translating this research to interventions. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.03.013DOI Listing

The Influence of Maternal Parenting Style on the Neural Correlates of Emotion Processing in Children.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Objective: The importance of parenting in influencing mental health outcomes, particularly depression, during childhood and adolescence is well known. However, the mechanisms are unclear. Emotion processing impairments in children are thought to be both influenced by negative parenting behaviors, and fundamental to depression. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.01.018DOI Listing

Hoarding Symptoms in Children and Adolescents With Obsessive-Compulsive Disorder: Clinical Features and Response to Cognitive-Behavioral Therapy.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

UCLA Semel Institute for Neuroscience & Human Behavior, Los Angeles, CA.

Objective: Although adult hoarding disorder is relatively common and often debilitating, few studies have examined the phenomenology of pediatric hoarding. We examined the clinical phenomenology and response to cognitive-behavioral therapy (CBT) treatment in youth with a diagnosis of obsessive-compulsive disorder (OCD) with and without hoarding symptoms. Age was tested as a moderator across analyses given prior findings that the impact of hoarding symptoms may not become apparent until adolescence. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.01.017DOI Listing
March 2019
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Patterns of Social Media Use Among Psychiatrically Hospitalized Adolescents.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

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http://dx.doi.org/10.1016/j.jaac.2019.03.009DOI Listing

Editorial: Structural Brain Alterations in Youth With Psychosis and Bipolar Spectrum Symptoms.

Authors:
Sophia Frangou

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.010DOI Listing

A Randomized Controlled Trial of Attention Bias Modification Treatment in Youth With Treatment-Resistant Anxiety Disorders.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Objective: Randomized clinical trials of augmentation strategies for youth with treatment-resistant anxiety disorders do not exist. We present findings from an efficacy trial of attention bias modification treatment (ABMT) as an augment for this population, in comparison with attention control training (ACT).

Method: Sixty-four youths (34 boys; M age=11. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.02.018DOI Listing
March 2019
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Out of Control: Examining the Association Between Family Conflict and Self-Control in Adolescence in a Genetically Sensitive Design.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Objective: Family conflict is associated with low self-control in adolescence. Thus far research about the direction of this association is inconclusive. In this study, we sort out whether this association reflects a causal effect or whether it is explained by a common underlying cause, including genetic factors. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.02.017DOI Listing

Children With Early-Onset Disruptive Behavior: Parental Mental Disorders Predict Poor Psychosocial Functioning in Adolescence.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Leiden University Medical Center in Oegstgeest, The Netherlands; Center for Criminological and Psychosocial Research, Örebro University, Örebro, Sweden.

Objective: Parental mental disorders (MD) and child early-onset disruptive behavior (DB) are well-established risk factors for poor outcomes in adolescence. However, it is not clear whether parental MD increases risk of future maladjustment among children who already display DB.

Method: Parents of 9-year-old children reported on child DB, while a patient registry was used to determine parental MD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193019
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http://dx.doi.org/10.1016/j.jaac.2018.10.017DOI Listing
March 2019
9 Reads

Editorial: Using Parent's Past to Predict Children's Future: Testing Parental History of Mental Disorders as a Predictor of Outcomes in Children With Disruptive Behavior.

Authors:
Jasmin Wertz

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Duke University, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.011DOI Listing
March 2019
2 Reads

Out of Control: More Evidence That Both Family Ecology and Genetic Influences Contribute to the Origins of Poor Self-Control Among Adolescents.

Authors:
David J Bridgett

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Northern Illinois University, DeKalb. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.007DOI Listing

Editorial: Grief in Children: Phenomenology and Beyond.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

University of Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.jaac.2019.03.008DOI Listing
March 2019
3 Reads

The Distinctiveness of Grief, Depression, and Posttraumatic Stress: Lessons From Children After 9/11.

J Am Acad Child Adolesc Psychiatry 2019 Mar 12. Epub 2019 Mar 12.

Objective: The clinical and nosological significance of grief reactions in youth exposed to a shared trauma (9/11) was tested by examining whether the (1) predictors (i.e., non-loss related trauma vs. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.12.012DOI Listing
March 2019
8 Reads

Cardiometabolic Adverse Effects and Its Predictors in Children and Adolescents With First-Episode Psychosis During Treatment With Quetiapine-Extended Release Versus Aripiprazole: 12-Week Results From the Tolerance and Effect of Antipsychotics in Children and Adolescents With Psychosis (TEA) Trial.

J Am Acad Child Adolesc Psychiatry 2019 Mar 8. Epub 2019 Mar 8.

Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Objective: To investigate cardiometabolic effects and its predictors in youth with first-episode psychosis (FEP) treated with quetiapine-extended release (ER) vs. aripiprazole.

Method: Youths with FEP aged 12-17 years were randomized to quetiapine-ER or aripiprazole in the 12-week, double-blinded, Tolerability and Efficacy of Antipsychotics (TEA) trial. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.01.015DOI Listing
March 2019
3 Reads

A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment.

J Am Acad Child Adolesc Psychiatry 2019 Mar 8. Epub 2019 Mar 8.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, Germany; Development, Health, and Disease Research Program, University of California, Irvine. Electronic address:

Objective: Women exposed to childhood maltreatment (CM) are more likely to exhibit insensitive parenting, which may have consequences for their offspring´s development. Variation in the Oxytocin-receptor gene (OXTR) moderates risk of CM-associated long-term sequelae associated with mother-child attachment, although functionality of previously investigated SNPs remained elusive. Here, we investigated the role of OXTR rs237895, a brain tissue expression quantitative trait locus (eQTL), as a moderator of the relationship between CM and maternal behavior (MB) and the association between MB and offspring attachment security. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.03.006DOI Listing
March 2019
2 Reads

Editorial: Putting Practicality Into "P": Leveraging General Factor Models of Psychopathology in Clinical Intervention.

Authors:
John D Haltigan

J Am Acad Child Adolesc Psychiatry 2019 Mar 7. Epub 2019 Mar 7.

University of Toronto, The Centre for Addiction and Mental Health (CAMH), and The Hospital for Sick Children, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.005DOI Listing
March 2019
3 Reads

Editorial: Trials and Tribulations in Early Autism Intervention Research.

Authors:
Tony Charman

J Am Acad Child Adolesc Psychiatry 2019 Mar 7. Epub 2019 Mar 7.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.03.004DOI Listing
March 2019
3 Reads

Recurrence Risk of Autism in Siblings and Cousins: A Multi-National, Population-Based Study.

J Am Acad Child Adolesc Psychiatry 2019 Mar 6. Epub 2019 Mar 6.

Objective: Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrum disorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex.

Method: Population-based cohort study of 1998-2007 livebirths from California, Denmark, Finland, Israel, Sweden and Western Australia followed through 2011-2015. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.11.017DOI Listing
March 2019
4 Reads
7.260 Impact Factor

Cumulative Prevalence of Onset and Recurrence of Child Maltreatment Reports.

J Am Acad Child Adolesc Psychiatry 2019 Mar 6. Epub 2019 Mar 6.

Brown School of Social Work, Washington University in St. Louis, MO.

Objective: We estimated cumulative probabilities of onset and recurrences of child maltreatment reports from birth to age 11. Estimates were provided overall and within subcategories of race/ethnicity, gender, and subtype.

Method: We developed synthetic life tables from national Child Protective Services records (2003-2016) and Census data. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.02.015DOI Listing

Parent-Based Treatment as Efficacious as Cognitive Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions.

J Am Acad Child Adolesc Psychiatry 2019 Mar 6. Epub 2019 Mar 6.

Yale University Child Study Center, New Haven, CT.

Objective: Treatment for childhood anxiety disorders is insufficient in many cases. Parent involvement has been examined as an augment to child-based cognitive behavioral therapy (CBT), but no studies have compared the efficaciousness of stand-alone parent-based treatment to CBT. Research implicates family accommodation in the maintenance and course of childhood anxiety. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.02.014DOI Listing
March 2019
8 Reads

Longitudinal Associations Between Sleep Patterns and Psychiatric Symptom Severity in High-Risk and Community Comparison Youth.

J Am Acad Child Adolesc Psychiatry 2019 Mar 6. Epub 2019 Mar 6.

University of Pittsburgh, PA.

Objective: Sleep disturbance may be involved in symptom progression across multiple domains of psychopathology and could represent a target for treatment development in youth. Our objective was to identify sleep patterns that longitudinally change in conjunction with psychiatric symptom severity in at-risk youth.

Method: The study included 484 Pittsburgh Bipolar Offspring Study youth with at least two sleep assessments occurring between 10 and 18 years-old: 267 offspring of parents with bipolar I or II disorder and 217 community comparison offspring. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.448DOI Listing
March 2019
1 Read

Typical Levels of Eye-Region Fixation in Toddlers With ASD Across Multiple Contexts.

J Am Acad Child Adolesc Psychiatry 2019 Mar 6. Epub 2019 Mar 6.

University of California, San Diego Autism Center of Excellence. Electronic address:

Objective: Unusual eye contact is a common clinical feature in ASD, yet eye tracking studies that quantify eye fixation reveal inconsistent results, possibly due to small sample sizes, varied stimuli, and considerable heterogeneity of eye-region fixation even within typical development. Goals were to examine: (1) eye-region fixation levels in a large, very young cohort; (2) the degree to which the presence of speech, hand gestures, and a geometric distractor influence eye-region fixation; and (3) possible developmental changes across time.

Method: In Experiment 1, 385 toddlers (143 with ASD; 242 non-ASD, 11 to 47 months) watched an actress engaging in child-directed speech with hand gestures against a plain background. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193017
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http://dx.doi.org/10.1016/j.jaac.2018.12.011DOI Listing
March 2019
30 Reads

Editorial: Does an Attention-Deficit/Hyperactivity Disorder Pill a Day Keep Failing Grades Away?

J Am Acad Child Adolesc Psychiatry 2019 Apr 5;58(4):395-397. Epub 2019 Mar 5.

Penn State College of Medicine, Hershey, PA.

Numerous studies have found that attention-deficit/hyperactivity disorder (ADHD) significantly impairs academic functioning. Observed impairments span diverse outcomes, from grade point average (GPA) and standardized test scores to grade retention and dropout. The impact of treating ADHD on academic functioning has received appreciable attention but remains a topic of debate because of the mixed and somewhat underwhelming results to date. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.01.014DOI Listing
April 2019
3 Reads

Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project.

J Am Acad Child Adolesc Psychiatry 2019 Mar 4. Epub 2019 Mar 4.

Tulane University School of Medicine, New Orleans, LA.

Objective: Telomere length has been linked to several psychiatric conditions in children and adults. Telomere shortening is accelerated by early adversity, including maltreatment and psychosocial deprivation. These experiences also increase the risk of psychopathology in many domains. Read More

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http://dx.doi.org/10.1016/j.jaac.2019.02.013DOI Listing

Leaping Over Walls.

Authors:
Craigan Usher

J Am Acad Child Adolesc Psychiatry 2019 Mar;58(3):378

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http://dx.doi.org/10.1016/j.jaac.2019.01.002DOI Listing

Whole Exome Sequencing Guides Pharmacotherapy for an Adolescent With Autism Spectrum Disorder and Psychosis.

J Am Acad Child Adolesc Psychiatry 2019 Mar;58(3):376-377

Naval Medical Center, San Diego, CA.

Genomic testing, including whole exome sequencing (WES), can result in specific changes to medical management. To illustrate the clinical utility of WES for complex neuropsychiatric disease, we report a male adolescent with autism spectrum disorder, psychosis, and regression and discuss how the WES findings guided his pharmacologic management. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.432DOI Listing