112 results match your criteria Journal of signal transduction[Journal]


Thyroid Hormones as Renal Cell Cancer Regulators.

J Signal Transduct 2016 13;2016:1362407. Epub 2016 Mar 13.

Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.

It is known that thyroid hormone is an important regulator of cancer development and metastasis. What is more, changes across the genome, as well as alternative splicing, may affect the activity of the thyroid hormone receptors. Mechanism of action of the thyroid hormone is different in every cancer; therefore in this review thyroid hormone and its receptor are presented as a regulator of renal cell carcinoma. Read More

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http://dx.doi.org/10.1155/2016/1362407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808550PMC
April 2016
6 Reads

Analysis of AKAP7γ Dimerization.

J Signal Transduct 2015 31;2015:371626. Epub 2015 Aug 31.

Pat and Jim Calhoun Center for Cardiology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that contribute to spatiotemporal regulation of PKA-mediated phosphorylation events. In particular, AKAP7 is a family of alternatively spliced proteins that participates in cardiac calcium dynamics. Here, we demonstrate via pull-down from transfected cells and by direct protein-protein association that AKAP7γ self-associates. Read More

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https://www.hindawi.com/archive/2015/371626/
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http://dx.doi.org/10.1155/2015/371626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568377PMC
September 2015
10 Reads

Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling.

Authors:
Travis J Jerde

J Signal Transduct 2015 3;2015:282567. Epub 2015 Aug 3.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, IU-Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.

Phosphatase and tensin homologue (PTEN) is a critical cell endogenous inhibitor of phosphoinositide signaling in mammalian cells. PTEN dephosphorylates phosphoinositide trisphosphate (PIP3), and by so doing PTEN has the function of negative regulation of Akt, thereby inhibiting this key intracellular signal transduction pathway. In numerous cell types, PTEN loss-of-function mutations result in unopposed Akt signaling, producing numerous effects on cells. Read More

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http://dx.doi.org/10.1155/2015/282567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539077PMC
September 2015
3 Reads

Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system.

J Signal Transduct 2014 11;2014:731350. Epub 2014 Nov 11.

Department of Pathophysiology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, 1113 Buenos Aires, Argentina.

The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Angiotensin II, atrial natriuretic peptide and intrarenal dopamine play a pivotal role in this interactive network. The balance between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide, by one side, and the prooxidant effect of the renin angiotensin system, by the other side, contributes to ensuring the normal function of the kidney. Read More

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https://www.hindawi.com/archive/2014/731350/
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http://dx.doi.org/10.1155/2014/731350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243602PMC
December 2014
7 Reads

Signaling Network Map of Endothelial TEK Tyrosine Kinase.

J Signal Transduct 2014 13;2014:173026. Epub 2014 Oct 13.

Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore 560066, India.

TEK tyrosine kinase is primarily expressed on endothelial cells and is most commonly referred to as TIE2. TIE2 is a receptor tyrosine kinase modulated by its ligands, angiopoietins, to regulate the development and remodeling of vascular system. It is also one of the critical pathways associated with tumor angiogenesis and familial venous malformations. Read More

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http://dx.doi.org/10.1155/2014/173026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211299PMC
November 2014
8 Reads
7 Citations

TGF- β Signaling Cooperates with AT Motif-Binding Factor-1 for Repression of the α -Fetoprotein Promoter.

J Signal Transduct 2014 3;2014:970346. Epub 2014 Jul 3.

Laboratory of Biochemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.

α-Fetoprotein (AFP) is known to be highly produced in fetal liver despite its barely detectable level in normal adult liver. On the other hand, hepatocellular carcinoma often shows high expression of AFP. Thus, AFP seems to be an oncogenic marker. Read More

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http://dx.doi.org/10.1155/2014/970346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106063PMC
August 2014
20 Reads

A Network Map of FGF-1/FGFR Signaling System.

J Signal Transduct 2014 16;2014:962962. Epub 2014 Apr 16.

Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.

Fibroblast growth factor-1 (FGF-1) is a well characterized growth factor among the 22 members of the FGF superfamily in humans. It binds to all the four known FGF receptors and regulates a plethora of functions including cell growth, proliferation, migration, differentiation, and survival in different cell types. FGF-1 is involved in the regulation of diverse physiological processes such as development, angiogenesis, wound healing, adipogenesis, and neurogenesis. Read More

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http://dx.doi.org/10.1155/2014/962962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009234PMC
June 2014
7 Reads

Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders.

J Signal Transduct 2014 24;2014:593934. Epub 2014 Feb 24.

Department of Clinical Pharmacology, China Medical University, No. 92 Beier Road, Heping District, Shenyang, China.

Chronic treatment with fluoxetine or other so-called serotonin-specific reuptake inhibitor antidepressants (SSRIs) or with a lithium salt "lithium", carbamazepine, or valproic acid, the three classical antibipolar drugs, exerts a multitude of effects on astrocytes, which in turn modulate astrocyte-neuronal interactions and brain function. In the case of the SSRIs, they are to a large extent due to 5-HT2B-mediated upregulation and editing of genes. These alterations induce alteration in effects of cPLA2, GluK2, and the 5-HT2B receptor, probably including increases in both glucose metabolism and glycogen turnover, which in combination have therapeutic effect on major depression. Read More

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http://dx.doi.org/10.1155/2014/593934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953578PMC
June 2014
2 Reads

Upregulation of voltage-gated calcium channel cav1.3 in bovine somatotropes treated with ghrelin.

J Signal Transduct 2013 18;2013:527253. Epub 2013 Dec 18.

Department of Cell Biology, Center for Research and Advanced Studies, National Polytechnic Institute, Mexico City, Mexico.

Activation of the growth hormone (GH) secretagogue receptor (GHS-R) by synthetic GH releasing peptides (GHRP) or its endogenous ligand (Ghrelin) stimulates GH release. Though much is known about the signal transduction underlying short-term regulation, there is far less information on the mechanisms that produce long-term effects. In the current report, using an enzyme-linked immunosorbent assay for GH detection and whole-cell patch-clamp recordings, we assessed the long-term actions of such regulatory factors on voltage-activated Ca(2+) currents in bovine somatotropes (BS) separated on a Percoll gradient and detected by immunohistochemistry. Read More

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http://dx.doi.org/10.1155/2013/527253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880704PMC
January 2014
3 Reads

AP-1 Gene Expression Levels May Be Correlated with Changes in Gene Expression of Some Stemness Factors in Colon Carcinomas.

J Signal Transduct 2013 11;2013:497383. Epub 2013 Dec 11.

Research Genetic Cancer Centre Ltd. (RGCC Ltd.), Filotas, 53070 Florina, Greece.

The AP-1 transcription factor is a heterodimer protein that regulates gene expression in response to a variety of extrinsic stimuli through signal transduction. It is involved in processes including differentiation, proliferation, and apoptosis. Among the genes it regulates are transcription factors that contribute to the stemness phenotype. Read More

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https://www.hindawi.com/archive/2013/497383/
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http://dx.doi.org/10.1155/2013/497383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874301PMC
January 2014
6 Reads

The functional state of hormone-sensitive adenylyl cyclase signaling system in diabetes mellitus.

J Signal Transduct 2013 28;2013:594213. Epub 2013 Sep 28.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez Avenue 44, Saint Petersburg 194223, Russia.

Diabetes mellitus (DM) induces a large number of diseases of the nervous, cardiovascular, and some other systems of the organism. One of the main causes of the diseases is the changes in the functional activity of hormonal signaling systems which lead to the alterations and abnormalities of the cellular processes and contribute to triggering and developing many DM complications. The key role in the control of physiological and biochemical processes belongs to the adenylyl cyclase (AC) signaling system, sensitive to biogenic amines and polypeptide hormones. Read More

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http://dx.doi.org/10.1155/2013/594213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804439PMC
June 2014
4 Reads

A Novel Interaction between Pyk2 and MAP4K4 Is Integrated with Glioma Cell Migration.

J Signal Transduct 2013 15;2013:956580. Epub 2013 Sep 15.

Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.

Glioma cell migration correlates with Pyk2 activity, but the intrinsic mechanism that regulates the activity of Pyk2 is not fully understood. Previous studies have supported a role for the N-terminal FERM domain in the regulation of Pyk2 activity as mutations in the FERM domain inhibit Pyk2 phosphorylation. To search for novel protein-protein interactions mediated by the Pyk2 FERM domain, we utilized a yeast two-hybrid genetic selection to identify the mammalian Ste20 homolog MAP4K4 as a binding partner for the Pyk2 FERM domain. Read More

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http://dx.doi.org/10.1155/2013/956580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791834PMC
October 2013
8 Reads

An fc gamma receptor-mediated upregulation of the production of interleukin 10 by intravenous immunoglobulin in bone-marrow-derived mouse dendritic cells stimulated with lipopolysaccharide in vitro.

J Signal Transduct 2013 18;2013:239320. Epub 2013 Jun 18.

Japan Blood Products Organization, Central Research Laboratory, Protein Pharmacology Research Section, 1-5-2 Minatojima Minami-machi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

Intravenous immunoglobulin (IVIG), a highly purified immunoglobulin fraction prepared from pooled plasma of several thousand donors, increased anti-inflammatory cytokine IL-10 production, while decreased proinflammatory cytokine IL-12p70 production in bone-marrow-derived mouse dendritic cells (BMDCs) stimulated with lipopolysaccharide (LPS). The changes of cytokine production were confirmed with the transcription levels of these cytokines. To study the mechanisms of this bidirectional effect, we investigated changes of intracellular molecules in the LPS-induced signaling pathway and observed that IVIG upregulated ERK1/2 phosphorylation while downregulated p38 MAPK phosphorylation. Read More

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http://downloads.hindawi.com/journals/jst/2013/239320.pdf
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http://dx.doi.org/10.1155/2013/239320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703884PMC
July 2013
7 Reads

Signals regulating adhesion dynamics.

J Signal Transduct 2012 31;2012:785196. Epub 2012 Dec 31.

Departments of Biological Sciences and Cancer Biology, Vanderbilt University, Nashville, TN 37235, USA.

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http://dx.doi.org/10.1155/2012/785196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549360PMC
January 2013
2 Reads

Signal transduction alterations in glioma: implications for diagnosis and therapy.

J Signal Transduct 2012 9;2012:704247. Epub 2012 Dec 9.

Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore" (IEOS), CNR, 80131 Naples, Italy.

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http://dx.doi.org/10.1155/2012/704247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523599PMC
January 2013
4 Reads

Commitment of Satellite Cells Expressing the Calcium Channel α2δ1 Subunit to the Muscle Lineage.

J Signal Transduct 2012 29;2012:460842. Epub 2012 Nov 29.

Department of Physiology and Biophysics and Center for Cardiovascular Research, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612, USA.

Satellite cells can maintain or repair muscle because they possess stem cell properties, making them a valuable option for cell therapy. However, cell transplants into skeletal muscle of patients with muscular dystrophy are limited by donor cell attachment, migration, and survival in the host tissue. Cells used for therapy are selected based on specific markers present in the plasma membrane. Read More

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http://dx.doi.org/10.1155/2012/460842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517858PMC
December 2012
4 Reads

Protein-tyrosine kinase signaling in the biological functions associated with sperm.

J Signal Transduct 2012 11;2012:181560. Epub 2012 Nov 11.

Laboratory of Cell Signaling and Development, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan.

In sexual reproduction, two gamete cells (i.e., egg and sperm) fuse (fertilization) to create a newborn with a genetic identity distinct from those of the parents. Read More

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https://www.hindawi.com/archive/2012/181560/
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http://dx.doi.org/10.1155/2012/181560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503396PMC
December 2012
10 Reads

Levels of Ca(V)1.2 L-Type Ca(2+) Channels Peak in the First Two Weeks in Rat Hippocampus Whereas Ca(V)1.3 Channels Steadily Increase through Development.

J Signal Transduct 2012 14;2012:597214. Epub 2012 Oct 14.

Department of Biological Sciences, Marquette University, P.O. Box 1881, Milwaukee, WI 53201, USA ; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled receptors such as GABA(B) receptors. Of the four isoforms of L-type channels, only Ca(V)1. Read More

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http://dx.doi.org/10.1155/2012/597214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477797PMC
October 2012
2 Reads

Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells.

J Signal Transduct 2012 9;2012:204236. Epub 2012 Oct 9.

Molecular Pathogenesis Group, National Toxicology Program (NTP) Laboratory, NTP, Department of Health and Human Services (DHHS), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC 27709, USA.

Estrogen and growth factors play a major role in uterine leiomyoma (UtLM) growth possibly through interactions of receptor tyrosine kinases (RTKs) and estrogen receptor-alpha (ERα) signaling. We determined the genomic and nongenomic effects of 17β-estradiol (E(2)) on IGF-IR/MAPKp44/42 signaling and gene expression in human UtLM cells with intact or silenced IGF-IR. Analysis by RT(2) Profiler PCR-array showed genes involved in IGF-IR/MAPK signaling were upregulated in UtLM cells by E(2) including cyclin D kinases, MAPKs, and MAPK kinases; RTK signaling mediator, GRB2; transcriptional factors ELK1 and E2F1; CCNB2 involved in cell cycle progression, proliferation, and survival; and COL1A1 associated with collagen synthesis. Read More

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https://www.hindawi.com/archive/2012/204236/
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http://dx.doi.org/10.1155/2012/204236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474284PMC
October 2012
5 Reads

Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.

J Signal Transduct 2012 27;2012:951497. Epub 2012 Sep 27.

Section of Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Pharmacology, Institute for Personalized Respiratory Medicine, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL 60612, USA.

Pulmonary circulation is an important circulatory system in which the body brings in oxygen. Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that predominantly affects women. Sustained pulmonary vasoconstriction, excessive pulmonary vascular remodeling, in situ thrombosis, and increased pulmonary vascular stiffness are the major causes for the elevated pulmonary vascular resistance (PVR) in patients with PAH. Read More

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http://dx.doi.org/10.1155/2012/951497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465915PMC
October 2012
5 Reads

The role of semaphorins and their receptors in gliomas.

J Signal Transduct 2012 23;2012:902854. Epub 2012 Sep 23.

Neurobiology/Ageing Programme, Department of Physiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Centre for Life Sciences, 28 Medical Drive, Singapore 117456.

Gliomas are the most common tumor in the central nervous system. High-grade glioblastomas are characterized by their high invasiveness and resistance to radiotherapy, leading to high recurrence rate and short median survival despite radical surgical resection. Characterizations of gliomas at molecular level have revealed aberrations of various growth factor receptors, receptor tyrosine kinases, and tumor suppressor genes that lead to deregulation of multiple signaling pathways, thereby contributing to abnormal proliferation, invasion, and resistance to apoptosis in cancer cells. Read More

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http://gu.med.harvard.edu/documents/gureview2013.pdf
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http://www.hindawi.com/journals/jst/2012/902854/
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http://dx.doi.org/10.1155/2012/902854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461631PMC
October 2012
4 Reads

Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses.

J Signal Transduct 2012 3;2012:483796. Epub 2012 Sep 3.

Laboratory of Cell Signaling and Development, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan ; Laboratory of Gene Biology, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh.

Protein-tyrosine phosphorylation, which is catalyzed by protein-tyrosine kinase (PTK), plays a pivotal role in a variety of cellular functions related to health and disease. The discovery of the viral oncogene Src (v-Src) and its cellular nontransforming counterpart (c-Src), as the first example of PTK, has opened a window to study the relationship between protein-tyrosine phosphorylation and the biology and medicine of cancer. In this paper, we focus on the roles played by Src and other PTKs in cancer cell-specific behavior, that is, evasion of apoptosis or cell death under stressful extracellular and/or intracellular microenvironments (i. Read More

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https://www.hindawi.com/archive/2012/483796/
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http://dx.doi.org/10.1155/2012/483796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439988PMC
September 2012
8 Reads

RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt.

J Signal Transduct 2012 5;2012:248759. Epub 2012 Sep 5.

Département d'Anatomie et Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4 ; Pharmacology Department, Weill Cornell Medical College, New York, NY 10065, USA.

Interactions between the extracellular matrix (ECM) and integrin receptors trigger structural and functional bonds between the cell microenvironment and the cytoskeleton. Such connections are essential for adhesion structure integrity and are key players in regulating transduction of specific intracellular signals, which in turn regulate the organization of the cell microenvironment and, consequently, cell function. The RGD peptide-dependent integrins represent a key subgroup of ECM receptors involved in the maintenance of epithelial homeostasis. Read More

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http://dx.doi.org/10.1155/2012/248759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440950PMC
September 2012
4 Reads

Prolonged Action Potential and After depolarizations Are Not due to Changes in Potassium Currents in NOS3 Knockout Ventricular Myocytes.

J Signal Transduct 2012 28;2012:645721. Epub 2012 Aug 28.

Department of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43221, USA.

Ventricular myocytes deficient in endothelial nitric oxide synthase (NOS3(-/-)) exhibit prolonged action potential (AP) duration and enhanced spontaneous activity (early and delayed afterdepolarizations) during β-adrenergic (β-AR) stimulation. Studies have shown that nitric oxide is able to regulate various K(+) channels. Our objective was to examine if NOS3(-/-) myocytes had altered K(+) currents. Read More

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http://dx.doi.org/10.1155/2012/645721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434404PMC
September 2012
6 Reads

The Role of HCN Channels on Membrane Excitability in the Nervous System.

J Signal Transduct 2012 13;2012:619747. Epub 2012 Aug 13.

Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8787, Japan.

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels were first reported in heart cells and are recently known to be involved in a variety of neural functions in healthy and diseased brains. HCN channels generate inward currents when the membrane potential is hyperpolarized. Voltage dependence of HCN channels is regulated by intracellular signaling cascades, which contain cyclic AMP, PIP(2), and TRIP8b. Read More

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https://www.hindawi.com/archive/2012/619747/
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http://dx.doi.org/10.1155/2012/619747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425855PMC
August 2012
6 Reads

Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway.

J Signal Transduct 2012 26;2012:473410. Epub 2012 Jul 26.

Cardiovascular Institute, Loyola University Chicago Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA.

Intracellular nitric oxide (NO(i)) is a physiological regulator of excitation-contraction coupling, but is also involved in the development of cardiac dysfunction during hypertrophy and heart failure. To determine whether contractile activity regulates nitric oxide synthase (NOS) expression, spontaneously contracting, neonatal rat ventricular myocytes (NRVM) were treat with L-type calcium channel blockers (nifedipine and verapamil) or myosin II ATPase inhibitors (butanedione monoxime (BDM) and blebbistatin) to produce contractile arrest. Both types of inhibitors significantly reduced iNOS but not eNOS expression, and also reduced NO(i) production. Read More

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http://dx.doi.org/10.1155/2012/473410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412095PMC
August 2012
4 Reads

Focal adhesion kinases in adhesion structures and disease.

J Signal Transduct 2012 19;2012:296450. Epub 2012 Jul 19.

Department of Oral Biology, Indiana University School of Dentistry, DS241, 1121 W. Michigan Street, Indianapolis, IN 46202, USA.

Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. Read More

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http://dx.doi.org/10.1155/2012/296450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409539PMC
August 2012
4 Reads

Prolactin and dexamethasone regulate second messenger-stimulated cl(-) secretion in mammary epithelia.

J Signal Transduct 2012 25;2012:192142. Epub 2012 Jul 25.

Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.

Mammary gland ion transport is essential for lactation and is regulated by prolactin and glucocorticoids. This study delineates the roles of prolactin receptors (PRLR) and long-term prolactin and dexamethasone (P-D)-mediation of [Ca(2+)](i) and Cl(-) transport in HC-11 cells. P-D (24 h) suppressed ATP-induced [Ca(2+)](i). Read More

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http://dx.doi.org/10.1155/2012/192142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410352PMC
August 2012
12 Reads

DNA methylation, histone modifications, and signal transduction pathways: a close relationship in malignant gliomas pathophysiology.

J Signal Transduct 2012 17;2012:956958. Epub 2012 Jul 17.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Alcalá, Carretera Madrid-Barcelona Km. 33.6, 28871 Madrid, Spain.

Gliomas are the most common type of primary brain tumor. Although tremendous progress has been achieved in the recent years in the diagnosis and treatment, its molecular etiology remains unknown. In this regard, epigenetics represents a new approach to study the mechanisms that control gene expression and function without changing the sequence of the genome. Read More

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https://www.hindawi.com/archive/2012/956958/
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http://dx.doi.org/10.1155/2012/956958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407642PMC
August 2012
11 Reads

Angiogenic signalling pathways altered in gliomas: selection mechanisms for more aggressive neoplastic subpopulations with invasive phenotype.

J Signal Transduct 2012 17;2012:597915. Epub 2012 Jul 17.

Laboratory of Clinical and Experimental Neuroscience (LaNCE), Department of Nursing I, University of the Basque Country, 48940 Leioa, Spain.

The angiogenesis process is a key event for glioma survival, malignancy and growth. The start of angiogenesis is mediated by a cascade of intratumoural events: alteration of the microvasculature network; a hypoxic microenvironment; adaptation of neoplastic cells and synthesis of pro-angiogenic factors. Due to a chaotic blood flow, a consequence of an aberrant microvasculature, tissue hypoxia phenomena are induced. Read More

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http://dx.doi.org/10.1155/2012/597915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407647PMC
August 2012
2 Reads

NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases.

J Signal Transduct 2012 18;2012:123253. Epub 2012 Jul 18.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada T6G 2E1.

Anaplastic lymphoma kinase (ALK) was first identified in 1994 with the discovery that the gene encoding for this kinase was involved in the t(2;5)(p23;q35) chromosomal translocation observed in a subset of anaplastic large cell lymphoma (ALCL). The NPM-ALK fusion protein generated by this translocation is a constitutively active tyrosine kinase, and much research has focused on characterizing the signalling pathways and cellular activities this oncoprotein regulates in ALCL. We now know about the existence of nearly 20 distinct ALK translocation partners, and the fusion proteins resulting from these translocations play a critical role in the pathogenesis of a variety of cancers including subsets of large B-cell lymphomas, nonsmall cell lung carcinomas, and inflammatory myofibroblastic tumours. Read More

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http://dx.doi.org/10.1155/2012/123253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407651PMC
August 2012
14 Reads

The phosphorylation-dependent regulation of mitochondrial proteins in stress responses.

J Signal Transduct 2012 15;2012:931215. Epub 2012 Jul 15.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

To maintain cellular homeostasis, cells are equipped with precise systems that trigger the appropriate stress responses. Mitochondria not only provide cellular energy but also integrate stress response signaling pathways, including those regulating cell death. Several lines of evidence suggest that the mitochondrial proteins that function in this process, such as Bcl-2 family proteins in apoptosis and phosphoglycerate mutase family member 5 (PGAM5) in necroptosis, are regulated by several kinases. Read More

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http://dx.doi.org/10.1155/2012/931215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403084PMC
August 2012
4 Reads

Elimination of the actin-binding domain in kelch-like 1 protein induces T-type calcium channel modulation only in the presence of action potential waveforms.

J Signal Transduct 2012 11;2012:505346. Epub 2012 Jul 11.

Neuroscience Graduate Program, Loyola University Chicago, Chicago, IL 60153, USA.

The Kelch-like 1 protein (KLHL1) is a neuronal actin-binding protein that modulates calcium channel function. It increases the current density of Ca(v)3.2 (α(1H)) calcium channels via direct interaction with α(1H) and actin-F, resulting in biophysical changes in Ca(v)3. Read More

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http://dx.doi.org/10.1155/2012/505346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401526PMC
August 2012
3 Reads

Receptor tyrosine kinases: molecular switches regulating CNS axon regeneration.

J Signal Transduct 2012 16;2012:361721. Epub 2012 Jul 16.

Neuropharmacology and Neurobiology Section, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

The poor or lack of injured adult central nervous system (CNS) axon regeneration results in devastating consequences and poor functional recovery. The interplay between the intrinsic and extrinsic factors contributes to robust inhibition of axon regeneration of injured CNS neurons. The insufficient or lack of trophic support for injured neurons is considered as one of the major obstacles contributing to their failure to survive and regrow their axons after injury. Read More

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http://dx.doi.org/10.1155/2012/361721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405719PMC
August 2012
5 Reads

Regulation of adherens junction dynamics by phosphorylation switches.

J Signal Transduct 2012 12;2012:125295. Epub 2012 Jul 12.

Mechanobiology Institute Singapore, National University of Singapore, Singapore 117411.

Adherens junctions connect the actin cytoskeleton of neighboring cells through transmembrane cadherin receptors and a network of adaptor proteins. The interactions between these adaptors and cadherin as well as the activity of actin regulators localized to adherens junctions are tightly controlled to facilitate cell junction assembly or disassembly in response to changes in external or internal forces and/or signaling. Phosphorylation of tyrosine, serine, or threonine residues acts as a switch on the majority of adherens junction proteins, turning "on" or "off" their interactions with other proteins and/or their enzymatic activity. Read More

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http://dx.doi.org/10.1155/2012/125295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403498PMC
August 2012
10 Reads

Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis.

J Signal Transduct 2012 5;2012:570183. Epub 2012 Jul 5.

Institute for Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Cytotoxic necrotizing factors (CNFs) encompass a class of autotransporter toxins produced by uropathogenic E. coli (CNF1) or Y. pseudotuberculosis (CNFy). Read More

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https://www.hindawi.com/archive/2012/570183/
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http://dx.doi.org/10.1155/2012/570183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398657PMC
August 2012
3 Reads

Antiangiogenic therapy for glioma.

J Signal Transduct 2012 8;2012:483040. Epub 2012 Jul 8.

Department of Pharmacology, CNR Institute of Neuroscience, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy.

Currently, antiangiogenic agents are routinely used for the treatment of patients with glioma. However, despite advances in pharmacological and surgical therapy, glioma remains an incurable disease. Indeed, the formation of an abnormal tumor vasculature and the invasion of glioma cells along neuronal tracts are proposed to comprise the major factors that are attributed to the therapeutic resistance of these tumors. Read More

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http://dx.doi.org/10.1155/2012/483040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399341PMC
August 2012
4 Reads

Pivotal Role of AKAP12 in the Regulation of Cellular Adhesion Dynamics: Control of Cytoskeletal Architecture, Cell Migration, and Mitogenic Signaling.

J Signal Transduct 2012 28;2012:529179. Epub 2012 Jun 28.

Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

Cellular dynamics are controlled by key signaling molecules such as cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). AKAP12/SSeCKS/Gravin (AKAP12) is a scaffold protein for PKA and PKC which controls actin-cytoskeleton reorganization in a spatiotemporal manner. AKAP12 also acts as a tumor suppressor which regulates cell-cycle progression and inhibits Src-mediated oncogenic signaling and cytoskeletal pathways. Read More

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http://dx.doi.org/10.1155/2012/529179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395252PMC
August 2012
4 Reads

The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease.

J Signal Transduct 2012 25;2012:649079. Epub 2012 Jun 25.

School of Life Sciences, The University of Warwick, Coventry CV4 7AL, UK.

A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases. In this review we will discuss the cellular localisation and activation of p38 MAPK and the recent advances on the molecular and cellular mechanisms of its substrates: MAPKAPK 2 (MK2) and tau protein. In particular we will focus our attention on the understanding of the p38 MAPK-MK2 and p38 MAPK-tau activation axis in controlling neuroinflammation, actin remodelling and tau hyperphosphorylation, processes that are thought to be involved in normal ageing as well as in neurodegenerative diseases. Read More

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http://dx.doi.org/10.1155/2012/649079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389708PMC
August 2012
3 Reads

Effects of somatic mutations in the C-terminus of insulin-like growth factor 1 receptor on activity and signaling.

J Signal Transduct 2012 14;2012:804801. Epub 2012 Jun 14.

Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

The insulin-like growth factor I receptor (IGF1R) is overexpressed in several forms of human cancer, and it has emerged as an important target for anticancer drug design. Cancer genome sequencing efforts have recently identified three somatic mutations in IGF1R: A1374V, a deletion of S1278 in the C-terminal tail region of the receptor, and M1255I in the C-terminal lobe of the kinase catalytic domain. The possible effects of these mutations on IGF1R activity and biological function have not previously been tested. Read More

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http://dx.doi.org/10.1155/2012/804801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384887PMC
August 2012
4 Reads

Beyond Genetics in Glioma Pathways: The Ever-Increasing Crosstalk between Epigenomic and Genomic Events.

Authors:
Ramón Martínez

J Signal Transduct 2012 18;2012:519807. Epub 2012 Jun 18.

Department of Neurosurgery, University of Goettingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany.

Diffuse gliomas are the most frequent brain tumor in adults. This group of brain neoplasms, ranging from histologically benign to aggressive malignant forms, represents a challenge in modern neurooncology because of the diffuse infiltrative growth pattern and the inherent tendency to relapse as a more malignant tumor. Once the disease achieves the stage of glioblastoma multiforme (GBM), the prognosis of patients is dismal and the median survival time is 15 months. Read More

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http://dx.doi.org/10.1155/2012/519807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385669PMC
August 2012
2 Reads

The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors.

J Signal Transduct 2012 14;2012:412089. Epub 2012 Jun 14.

Department of Biology and Biotechnology, Division of Biochemistry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.

Integrins and other families of cell adhesion receptors are responsible for platelet adhesion and aggregation, which are essential steps for physiological haemostasis, as well as for the development of thrombosis. The modulation of platelet adhesive properties is the result of a complex pattern of inside-out and outside-in signaling pathways, in which the members of the Rap family of small GTPases are bidirectionally involved. This paper focuses on the regulation of the main Rap GTPase expressed in circulating platelets, Rap1b, downstream of adhesion receptors, and summarizes the most recent achievements in the investigation of the function of this protein as regulator of platelet adhesion and thrombus formation. Read More

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http://dx.doi.org/10.1155/2012/412089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382407PMC
August 2012
3 Reads

Nucleic acids in human glioma treatment: innovative approaches and recent results.

J Signal Transduct 2012 21;2012:735135. Epub 2012 May 21.

Istituto per l'Endocrinologia e l'Oncologia Sperimentale del CNR "G. Salvatore", Via Pansini 5, 80131 Naples, Italy.

Gliomas are the most common primary central nervous system tumors with a dismal prognosis. Despite recent advances in surgery, radiotherapy, and chemotherapy, current treatment regimens have a modest survival benefit. A crucial challenge is to deliver drugs effectively to invasive glioma cells residing in a sanctuary within the central nervous system. Read More

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http://dx.doi.org/10.1155/2012/735135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364599PMC
August 2012
3 Reads

Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.

J Signal Transduct 2012 17;2012:421564. Epub 2012 May 17.

Dipartimento di Biologia Cellulare e Ambientale, Universita' di Perugia, Via Pascoli 1, I-06123 Perugia, Italy.

Glioblastomas are characterized by altered expression of several ion channels that have important consequences in cell functions associated with their aggressiveness, such as cell survival, proliferation, and migration. Data on the altered expression and function of the intermediate-conductance calcium-activated K (KCa3.1) channels in glioblastoma cells have only recently become available. Read More

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http://dx.doi.org/10.1155/2012/421564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362965PMC
August 2012
23 Reads

Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.

J Signal Transduct 2012 17;2012:414913. Epub 2012 May 17.

Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.

Abl is a nonreceptor tyrosine kinase and plays an essential role in the modeling and remodeling of F-actin by transducing extracellular signals. Abl and its paralog, Arg, are unique among the tyrosine kinase family in that they contain an unusual extended C-terminal half consisting of multiple functional domains. This structural characteristic may underlie the role of Abl as a mediator of upstream signals to downstream signaling machineries involved in actin dynamics. Read More

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http://dx.doi.org/10.1155/2012/414913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362954PMC
August 2012
4 Reads

In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase.

J Signal Transduct 2012 9;2012:694386. Epub 2012 May 9.

Department of Biology, Molecular Biology Institute and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182, USA.

ITK-SH3-mediated interactions, both with exogenous ligands and via intermolecular self-association with ITK-SH2, have been shown to be important for regulation of ITK activity. The biological significance of these competing SH3 interactions is not completely understood. A mutant of ITK where substitution of the SH3 domain with that of the related kinase BTK (ITK-BTK((SH3))) was used to disrupt intermolecular self-association of ITK while maintaining canonical binding to exogenous ligands such as SLP-76. Read More

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http://dx.doi.org/10.1155/2012/694386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357558PMC
August 2012
5 Reads

A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway.

J Signal Transduct 2012 9;2012:376470. Epub 2012 May 9.

Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.

TNF-related weak inducer of apoptosis (TWEAK) is a new member of the TNF superfamily. It signals through TNFRSF12A, commonly known as Fn14. The TWEAK-Fn14 interaction regulates cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, tissue remodeling and inflammation. Read More

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http://dx.doi.org/10.1155/2012/376470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357548PMC
August 2012
12 Reads

The role of bacteria in the pathogenesis of ulcerative colitis.

J Signal Transduct 2012 24;2012:704953. Epub 2012 Apr 24.

Division of Digestive Diseases, Atlanta Veterans Administration Medical Center, Emory University, Whitehead Biomedical Research Building, Suite 201, 615 Michael Street, Atlanta, GA 30322, USA.

Factors implicated in the pathophysiology of ulcerative colitis (UC) are an abnormal immune response, defect in intestinal epithelial barrier function, and gut microbiota. Currently, it is unclear whether specific bacterial strains are responsible for the induction of intestinal inflammation, but increased bacterial tissue invasion has been described in affected UC patients. Further, a quantitative and qualitative microbial imbalance in UC, defined as dysbiosis, has been characterized by an increase in Rhodococcus spp. Read More

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http://dx.doi.org/10.1155/2012/704953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348635PMC
August 2012
3 Reads

The role of phosphoinositide 3-kinase signaling in intestinal inflammation.

J Signal Transduct 2012 9;2012:358476. Epub 2012 Apr 9.

Mucosal Immunology Laboratory, Department of Pediatrics, 114 16th Street, Massachusetts General Hospital for Children, Charlestown MA 02129, USA.

The phosphatidylinositol 3-kinase signaling pathway plays a central role in regulating the host inflammatory response. The net effect can either be pro- or anti-inflammatory depending on the system and cellular context studied. This paper focuses on phosphatidylinositol 3-kinase signaling in innate and adaptive immune cells of the intestinal mucosa. Read More

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http://dx.doi.org/10.1155/2012/358476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337621PMC
August 2012
8 Reads
2 Citations

Crosstalk between p53 and TGF-β Signalling.

J Signal Transduct 2012 28;2012:294097. Epub 2012 Mar 28.

Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.

Wild-type p53 and TGF-β are key tumour suppressors which regulate an array of cellular responses. TGF-β signals in part via the Smad signal transduction pathway. Wild-type p53 and Smads physically interact and coordinately induce transcription of a number of key tumour suppressive genes. Read More

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http://dx.doi.org/10.1155/2012/294097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321553PMC
August 2012
4 Reads