6,704 results match your criteria Journal of separation science[Journal]


Ballpoint connector-protected salt-oil-salt liquid phase microextraction for concentration and enrichment of trace anthraquinone compounds in Rhubarb.

J Sep Sci 2019 Apr 25. Epub 2019 Apr 25.

School of Pharmacy, Shanxi Medical University, Taiyuan, P. R. China.

This paper proposed a new ballpoint connector-protected salt-oil-salt liquid phase microextraction for extraction and enrichment of trace rhein and chrysophanol in Rhubarb prior to determination of the analytes by high performance liquid chromatography. In this study, a handy ballpoint connector (between ballpoint tip and ink chamber) was used as extraction device, in which its cavity was filled with n-octanol, and the bare n-octanol in its two opening ends was covered with a thin layer of sodium chloride film. The design subtly assembled salt film onto ballpoint connector for extraction and enrichment, which greatly improved the enrichment factors of the target analytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900040DOI Listing
April 2019
2.737 Impact Factor

Simultaneous determination of nine trace concentration angiotensin peptides in human serum using ultra performance liquid chromatography-mass spectrometry tandem with sephadex LH-20 gel solid-phase extraction.

J Sep Sci 2019 Apr 25. Epub 2019 Apr 25.

Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, P. R. China.

The renin angiotensin system is a highly complex enzymatic system consisting of multiple peptide hormones, enzymes, and receptors. Here, an assay to simultaneously quantify eight angiotensin peptides and bradykinin in human serum was developed and validated, using ultra-performance liquid chromatography coupled with tandem mass spectrometry. A pre-concentration method of Sephadex LH-20 gel solid-phase extraction was firstly applied for analysis of angiotensin peptides from serum sample. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801276DOI Listing

Profiling the constituents of Dachuanxiong decoction by liquid chromatography-high resolution tandem mass spectrometry using target and nontarget data mining.

J Sep Sci 2019 Apr 24. Epub 2019 Apr 24.

Beijing Research Institute of Chinese Medicine, Beijing, P. R. China.

Comprehensive characterization of the large number of compounds existing in traditional Chinese medicines is still a great challenge. In this paper, a strategy of precursor ion selected acquisition coupled with target and nontarget data mining was established to systematically characterize the chemical constituents of traditional Chinese medicines. This strategy consisted of four steps: 1) precursor ion selected acquisition was developed to trigger additional MS/MS fragmentation reactions, especially for trace constituents; 2) in-house database of compounds was established and diagnostic characteristics were summarized; 3) compounds were identified by target and nontarget data mining; 4) compound structures were elucidated based on accurate mass matching and comparison of fragment ions, and isomers were discriminated by the intensity of fragment ions, fragmentation pattern analysis and calculated logP values. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900064DOI Listing

Preparative isolation and purification of steroidal glycoalkaloid from the ripe berries of Solanum nigrum L. by preparative HPLC-MS and ultra high performance liquid chromatography time-of-flight-MS/MS and its anti-non-small cell lung tumours effects in vitro and in vivo.

J Sep Sci 2019 Apr 23. Epub 2019 Apr 23.

School of Pharmaceutical Sciences, Capital Medical University, Beijing, P. R. China.

Overcoming epidermal growth factor receptor resistance is a critical problem that needs to be solved in clinical practice. Drugs that downregulate the fatty acid synthase-epidermal growth factor receptor will become novel treatments for non-small cell lung cancer. Solanum nigrum, extracted with water at 4°C, shows strong cytotoxic activity and inhibits tumour growth in Lewis tumour bearing-mice in a dose-dependent manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801165DOI Listing

Fast determination of 14 mycotoxins in chestnut by dispersive solid-phase extraction coupled with ultra-performance liquid chromatography-tandem mass spectrometry.

J Sep Sci 2019 Apr 23. Epub 2019 Apr 23.

Institute of Agricultural Quality Standards and Testing Technology Research, Shandong Academy of Agricultural Sciences, Jinan, P. R. China.

A dispersive solid-phase extraction coupled with ultra-performance liquid chromatography-MS/MS method was developed and validated for the simultaneous determination of T-2 toxin, penicillic acid, fumonisins B , B , and B , aflatoxins B , B , G , and G , ochratoxin A, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, and zearalenone in chestnut samples. The method was used to analyse 136 samples obtained from Shandong province in China. The mycotoxins were extracted using a dispersive solid-phase extraction method and cleaned using an improved quick, easy, cheap, effective, rugged, and safe approach. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.2019000
Publisher Site
http://dx.doi.org/10.1002/jssc.201900050DOI Listing
April 2019
1 Read

Three phase hollow-fiber liquid-phase microextraction based on deep eutectic solvent as acceptor phase for extraction and preconcentration of main active compounds in a traditional Chinese medicinal formula.

J Sep Sci 2019 Apr 23. Epub 2019 Apr 23.

School of Pharmacy, Shanxi Medical University, Taiyuan, 030001, P. R. China.

A three phase hollow-fiber liquid-phase microextraction based on deep eutectic solvent as acceptor phase was developed and coupled with HPLC for the simultaneous extraction, enrichment, and determination of main active compounds (hesperidin, honokiol, shikonin, magnolol, emodin, and β,β'-dimethylacrylshikonin) in a traditional Chinese medicinal formula. In this procedure, two hollow fibers, impregnated with n-heptanol:n-nonanol (7:3, v/v) mixture in wall pores as the extraction phase and a combination (9:1, v/v) of methyltrioctylammonium chloride-glycerol (1:3, n/n) and methanol in lumen as the acceptor phase, were immersed in the aqueous sample phase. The target analytes in the sample solution were first extracted through the organic phase, and further back-extracted to the acceptor phase during the stirring process. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.2019001
Publisher Site
http://dx.doi.org/10.1002/jssc.201900184DOI Listing
April 2019
1 Read

Solid-phase extraction of phenoxyacetic acid herbicides in complex samples with Zr (IV)-based metal-organic framework.

J Sep Sci 2019 Apr 18. Epub 2019 Apr 18.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Chinese Academy of Sciences, Lanzhou Institute of Chemical Physics, Lanzhou, P. R. China.

A zirconium (IV)-based metal organic framework material (MOF-808) has been synthesized in a simple way and used for extraction of phenoxyacetic acids in complex samples. The material has good thermal and chemical stability, large specific surface area (905.36 m²/g) and high pore size (22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900243DOI Listing
April 2019
2 Reads

Dispersive liquid-liquid microextraction coupled with pressure-assisted electrokinetic injection for simultaneous enrichment of seven phenolic compounds in water samples followed by determination using capillary electrophoresis.

J Sep Sci 2019 Apr 18. Epub 2019 Apr 18.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China.

Off-line dispersive liquid-liquid microextraction combined with on-line pressure-assisted electrokinetic injection was developed to simultaneously enrich seven phenolic compounds in water samples, followed by determination using capillary electrophoresis, namely phenol, 4-chlorophenol, pentachlorophenol, 2,4,6-trichlorophenol, 2,4-dichlorophenol, 2-chlorophenol and 2,6-dichlorophenol. Several parameters affecting separation performance of capillary electrophoresis and the enrichment efficiency of pressure-assisted electrokinetic injection and dispersive liquid-liquid microextraction were systematically investigated. Under the optimal conditions, seven phenolic compounds were completely separated within 14 min and good enrichment factors were obtained of 61, 236, 3705, 3288, 920, 86 and 1807 for phenol, 4-chlorophenol, pentachlorophenol, 2,4,6-trichlorophenol, 2,4-dichlorophenol, 2-chlorophenol and 2,6-dichlorophenol, respectively. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.2019001
Publisher Site
http://dx.doi.org/10.1002/jssc.201900106DOI Listing
April 2019
2 Reads

Polydopamine-coated cotton fibers as the adsorbent for in-tube solid-phase microextraction.

J Sep Sci 2019 Apr 18. Epub 2019 Apr 18.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China.

The polydopamine was coated onto cotton fibers as the adsorbent to improve the extraction efficiency. Polydopamine-coated cotton fibers were placed into a polyetheretherketone tube for in-tube solid-phase microextraction. To develop online analysis system, the extraction tube was connected with high performance liquid chromatography. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.2018013
Publisher Site
http://dx.doi.org/10.1002/jssc.201801333DOI Listing
April 2019
2 Reads

Development and optimization of a supercritical fluid chromatography tandem mass spectrometry method for the high-throughput determination of nimodipine in beagle plasma.

J Sep Sci 2019 Apr 17. Epub 2019 Apr 17.

Wuya College of Innovation, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, PR China.

A simple, sensitive and efficient supercritical fluid chromatography tandem mass spectrometry method was established for the determination of nimodipine in beagle plasma. One-step protein precipitation with acetone was used to extract the analytes from the plasma. Nitrendipine was used as the internal standard. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900134DOI Listing
April 2019
1 Read

Carbonized cotton fibers via a facile method for highly sensitive solid-phase microextraction of polycyclic aromatic hydrocarbons.

J Sep Sci 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China.

Cotton fiber is an environmental and natural material with a certain extraction capacity, while its enrichment ability is poor. In order to improve the extraction efficiency of cotton fibers, it was carbonized to form a layer of amorphous carbon as the sorbent by a simple carbonization method. Carbonized cotton fibers were filled into a polyetheretherketone tube for in-tube solid-phase microextraction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900076DOI Listing
April 2019
1 Read

Extraction and determination of bioactive flavonoids from Abelmoschus manihot (Linn.) Medicus flowers using deep eutectic solvents coupled with high performance liquid chromatography.

J Sep Sci 2019 Apr 16. Epub 2019 Apr 16.

School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, P. R. China.

A highly efficient and ecofriendly extraction method using deep eutectic solvents as solvents was developed to extract bioactive flavonoids from Abelmoschus manihot (Linn.) Medicus flowers. Firstly, a series of deep eutectic solvents using choline chloride as hydrogen bond acceptor with different hydrogen bond donors were successfully synthesized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900031DOI Listing
April 2019
1 Read

Highly Sensitive and Selective Method for Rapid Determination and Preconcentration of Haloperidol by using Magnetite-Molecularly Imprinted Polymer.

J Sep Sci 2019 Apr 13. Epub 2019 Apr 13.

School of Medicine, Department of Psychiatry, Ege University, Bornova, Izmir, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900158DOI Listing
April 2019
1 Read

Matrix solid-phase dispersion coupled with hollow fiber liquid phase microextraction for determination of triazine herbicides in peanuts.

J Sep Sci 2019 Apr 13. Epub 2019 Apr 13.

College of Chemistry, Jilin University, Qianjin, Changchun, P. R. China.

In this article, two extraction procedures, matrix solid phase dispersion and hollow fiber liquid phase microextraction, were combined and applied to determine triazine herbicides in peanut samples. The results showed that the established method has high extraction efficiency and could greatly eliminate the interferences from complex matrix samples. A series of important experimental parameters were all investigated in detail. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.2018012
Publisher Site
http://dx.doi.org/10.1002/jssc.201801213DOI Listing
April 2019
6 Reads

Use of graphene coated with ZnO nanocomposites for microextraction in packed syringe of carbamate pesticides from juice samples.

J Sep Sci 2019 Apr 12. Epub 2019 Apr 12.

College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455000, P. R. China.

In this work, nanocomposites of reduced graphene oxide coated with ZnO were synthesized using a hydrothermal reduction strategy. It was then used as a sorbent for microextraction in a packed syringe and its application to the extraction of carbamate pesticides from juice samples prior to HPLC detection was demonstrated. Factors affecting the enrichment efficiency of the microextraction in a packed syringe procedure were optimized, including desorption conditions, sample pH, salting-out effect, washing solution, and sample cycles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900257DOI Listing
April 2019
1 Read

Organized Cryogel Composites with 3D Hierarchical Porosity as an Extraction Adsorbent for Nucleosides.

J Sep Sci 2019 Apr 12. Epub 2019 Apr 12.

College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.

Macroscopic monoliths are highly desired in many fields of application. Herein, well-organized organic-inorganic cryogel composite with a three-dimensional hierarchical meso- and macroporous structure are presented, which were produced by in situ copolymerization of mesoporous multifunctional silica (size: 1 to 20 μm; pore: 2 to 20 nm mostly) and monomers (hydroxyethyl methacrylate and diallyldimethylammonium chloride) in water below the freezing point. This copolymerization method effectively adjusted the macropores of the basic cryogel, and the nanosilica was more homogeneously dispersed in the basic cryogel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900174DOI Listing
April 2019
1 Read

Metabolites study on 5-O-methylvisammioside in vivo and in vitro by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.

J Sep Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.

5-O-methylvisammioside is one of major chromones of Radix Saposhnikoviae possessing definite pharmacological activities, but there are few reports with respect to the metabolism of 5-O-methylvisammioside. In this work, metabolites in vivo explored on male Sprague Dawley rats and in vitro investigated on rat intestinal bacteria incubation model were identified by using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. An on-line data acquisition method based on a multiple mass defect filter and dynamic background subtraction was developed to trace all probable metabolites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900001DOI Listing
April 2019
1 Read

A novel foam based separation strategy for extracting minute target impurities.

J Sep Sci 2019 Apr 10. Epub 2019 Apr 10.

Laboratory of Bioseparation Technology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm 5D18, Bethesda, MD, 20892, USA.

The purpose of this study was to extract impurities from compounds using a simple separatory bottle to purify target compounds with a foam column and allow for the further characterization of impurities. Charged dyes were used as target compounds due to the ease of detection of dyes and isolated impurities. Foaming agents were used in a glass bottle with a modified cap to separate a target impurity using an appropriately charged ligand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900057DOI Listing
April 2019
2 Reads

Thermodynamics-based modelling of GC separations across column geometries and GC systems including the prediction of peak widths.

J Sep Sci 2019 Apr 9. Epub 2019 Apr 9.

Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada.

Thermodynamics-based models have been demonstrated to be useful for predicting retention time and peak widths in GC and GC × GC separations. However, the collection of data to train the models can be time consuming, which lessens the practical utility of the method. In this contribution, a method for obtaining thermodynamic-based data to predict peak widths in temperature-programmed GC is presented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801294DOI Listing
April 2019
1 Read

Highly selective separation and detection of cyromazine from seawater using graphene oxide based molecularly imprinted solid-phase extraction.

J Sep Sci 2019 Apr 9. Epub 2019 Apr 9.

Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, P. R. China.

A novel molecularly imprinted polymer based on graphene oxide was prepared as a solid-phase extraction adsorbent for the selective adsorption and extraction of cyromazine from seawater samples. The obtained graphene oxide molecularly imprinted polymer and non-imprinted polymer were nanoparticles and characterized by scanning electron microscopy. The imprinted polymer showed higher adsorption capacity and better selectivity than non-imprinted polymer, and the maximum adsorption capacity was 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900232DOI Listing
April 2019
1 Read

Separation and purification of lanosterol, dihydrolanosterol, and cholesterol from lanolin by high-performance counter-current chromatography dual-mode elution method.

J Sep Sci 2019 Apr 5. Epub 2019 Apr 5.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University, Beijing, P. R. China.

Lanosterol is a potential drug for cataracts treatment, which can reverse the aggregation of intracrystalline proteins. The low concentration in lanolin calls for high-performance separation methods. In this study, a counter-current chromatography dual-mode elution method was developed for the first time to separate and purify lanosterol from hexane extract of lanolin after saponification, in which the column was first eluted with the lower phase as mobile phase in head-to-tail mode, followed by the upper phase in the tail-to-head mode. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.2019000
Publisher Site
http://dx.doi.org/10.1002/jssc.201900063DOI Listing
April 2019
4 Reads

Magnetic mesoporous polyimide composite for efficient extraction of Rhodamine B in food samples.

J Sep Sci 2019 Apr 4. Epub 2019 Apr 4.

Center for Advanced Analysis and Computational Science, Zhengzhou University, Zhengzhou, P. R. China.

A core-shell structured magnetic polyimide composite has been synthesized by the covalent coating of a mesoporous polyimide polymer onto the surface of magnetite nanoparticles. The nanocomposite was characterized by scanning electron microscopy, transmission electron microscopy, N adsorption-desorption isotherms, X-ray diffraction, infrared spectroscopy, and vibrating sample magnetometry. The results showed that the prepared composite had a large surface area (306. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900054DOI Listing
April 2019
3 Reads

A strategy for screening trypsin inhibitors from traditional Chinese medicine based on a monolithic capillary immobilized enzyme reactor coupled with offline liquid chromatography and mass spectrometry.

J Sep Sci 2019 Apr 4. Epub 2019 Apr 4.

Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

A novel strategy was successfully developed for screening trypsin inhibitors in traditional Chinese medicines based on monolithic capillary immobilized enzyme reactors combined with liquid chromatography-tandem mass spectrometry. Organic polymer based monolithic enzyme reactors were firstly prepared by covalently bonding trypsin to a poly(glycidyl methacrylate-co-poly (ethylene glycol) diacrylate) monolith by the ring-opening reaction of epoxy groups. The activity and kinetic parameters of the obtained monolithic trypsin reactors were systematically evaluated using micro-liquid chromatography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900169DOI Listing
April 2019
17 Reads

Microextraction by packed sorbent followed by ultra high performance liquid chromatography for the fast extraction and determination of six antidepressants in urine.

J Sep Sci 2019 Apr 4. Epub 2019 Apr 4.

Department of Analytical Chemistry, Faculty of Chemistry and Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, La Coruña, Spain.

The growing use of antidepressants in recent years has led to their increasing presence in forensic analyses. In this work, microextraction by packed sorbent followed by ultra-performance liquid chromatography with photodiode array detection provided a fast method for determining the antidepressants mirtazapine, venlafaxine, escitalopram, fluoxetine, fluvoxamine, and sertraline in human urine. The microextraction conditions (viz. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900060DOI Listing
April 2019
1 Read

Comprehensive characterization and quantification of multiple components in Dan-Huang-Qu-Yu capsule using a multivariate data processing approach based on microwave-assisted extraction with UHPLC and Q Exactive quadrupole-orbitrap high-resolution mass spectrometry.

J Sep Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.

Dan-Huang-Qu-Yu capsule, a Chinese herbal medicine compound preparation, is widely used for chronic pelvic inflammatory disease. In this study, a rapid, selective, and sensitive microwave-assisted extraction ultra-high-performance liquid chromatography-Q Exactive quadrupole-orbitrap high-resolution mass spectrometry method was developed for analyzing its chemical compositions. A total of 85 compounds, including 22 flavonoids, 8 terpenoids, 5 quinones, 5 phthaleolactone, 23 organic acids, and 22 other compounds were identified from Dan-Huang-Qu-Yu capsule. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801246DOI Listing
April 2019
4 Reads

Rapid electrophoretic monitoring of the anaesthetic ketamine and its metabolite norketamine in rat blood using a contactless conductivity detector to study the pharmacokinetics.

J Sep Sci 2019 Apr 1. Epub 2019 Apr 1.

Department of Physiology, Third Faculty of Medicine, Charles University, Prague, Czechia.

A method of capillary electrophoresis with contactless conductivity detection has been developed for non-enantioselective monitoring the anaesthetic ketamine and its main metabolite norketamine. The separation is performed in a 15 μm capillary with an overall length of 31.5 cm and length to detector of 18 cm; inner surface of the capillary is covered with a commercial coating solution to reduce the electroosmotic flow. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900116DOI Listing
April 2019
3 Reads

Solidification of floating organic droplet microextraction for determination of seven insecticides in fruit juice, vegetables and agricultural runoff using gas chromatography with flame ionization and mass spectrometry detection.

J Sep Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Chemistry, Faculty of Science and Technology, Thammasat University, Khlong Luang, Pathumthani, Thailand.

Liquid microextraction employing solidification of the floating organic droplet, with vortexing and heating to optimize extraction efficiency, was developed for the determination of seven insecticides in fruit juice, vegetables, and agricultural runoff water. The extracts were analyzed by gas chromatography with both flame ionization and mass spectrometry detection for the determination of chlorpyrifos, prothiofos, profenofos, ethion, λ-cyhalothrin, permethrin, and cypermethrin, respectively. Using 20 μL of 1-undecanol in 10 mL of aqueous solution containing 1% w/v sodium chloride provided preconcentration factor of 500. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.2018011
Publisher Site
http://dx.doi.org/10.1002/jssc.201801193DOI Listing
April 2019
3 Reads

Investigation of free and conjugated seleno-amino acids in wheat bran by hydrophilic interaction liquid chromatography with tandem mass spectrometry.

J Sep Sci 2019 Mar 28. Epub 2019 Mar 28.

Dipartimento di Chimica, Sapienza Università di Roma, Rome, Italy.

An analytical method for determining seleno-methionine, methyl-seleno-cysteine, and seleno-cystine in wheat bran was developed and validated. Four different extraction procedures were evaluated to simultaneously extract endogenous free and conjugated seleno-amino acids in wheat bran in order to select the best extraction protocol in terms of seleno amino acid quantitation. The extracted samples were subjected to a clean-up by a reversed phase/strong cation exchange solid-phase extraction and analyzed by chiral hydrophilic interaction liquid chromatography-tandem mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900047DOI Listing
March 2019
1 Read

Multi-scale Gaussian/Haar wavelet strategies coupled with sub-window factor analysis for an accurate alignment in nontargeted metabolic profiling to enhance herbal origin discrimination capability.

J Sep Sci 2019 Mar 27. Epub 2019 Mar 27.

Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, P. R. China.

Metabolic dataset can provide an overview of different herbal origin, which is conducted by some statistical procedures. Such results often deviate to a certain degree, due to peaks shifts in chromatographic signals. In order to solve this problem, an improved algorithm of combining sub-window factor analysis with the mass spectrum information is proposed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801077DOI Listing

Evaluating novel silica hydride-based stationary phases for the analysis of phytocannabinoids and other psychoactive drugs.

J Sep Sci 2019 Mar 27. Epub 2019 Mar 27.

Department of Chemistry, San José State University, San Jose, USA.

Three silica hydride based novel chromatographic phases chemically-bonded with allyloxy-DL-alpha-tocopherol, allylpentafluorophenyl, and 1-eicosene moieties were evaluated as separation media for selected phytocannabinoids and other substances of abuse. In order to assess column selectivity, a series of reference standards was analyzed and detected by using liquid chromatography with mass spectrometry. Further, quantitative detections of cannabidiol and tetrahydrocannabinol were attempted for the extracts of cannabis plants and cannabidiol gummy formulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900013DOI Listing
March 2019
1 Read

Sol-gel technique for the preparation of β-cyclodextrin gold nanoparticles as chiral stationary phase in open-tubular capillary electrochromatography.

J Sep Sci 2019 Mar 27. Epub 2019 Mar 27.

College of Pharmacy, Dalian Medical University, Dalian, Liaoning Province, P. R. China.

A novel open-tubular capillary electrochromatography column coated with β-cyclodextrin was prepared using the sol-gel technique. In the sol-gel approach, owing to the three-dimensional network of sol-gel and the strong chemical bond between the stationary phase and the surface of capillary columns, good chromatographic characteristics and unique selectivity in separating enantiomers were shown. The influences of capillary inner diameter, coating time, organic modifier, buffer pH, and buffer concentration on separation were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900071DOI Listing
March 2019
1 Read

Molecularly imprinted polymeric shell coated monodisperse-porous silica microspheres as a stationary phase for microfluidic boronate affinity chromatography.

J Sep Sci 2019 Mar 22. Epub 2019 Mar 22.

Department of Chemical Engineering, Hacettepe University, Ankara, Turkey.

Molecular imprinting of cis-diol functionalized agents via boronate affinity interaction has been usually performed using nanoparticles as a support which cannot be utilized as a stationary phase in continuous microcolumn applications. In this study, monodisperse-porous, spherical silica particles in the micron-size range, with bimodal pore diameter distribution were selected as a new support for the synthesis of a molecularly imprinted boronate affinity sorbent, using a cis-diol functionalized agent as the template. A specific surface area of 158 m /g was achieved with the imprinted sorbent by using monodisperse-porous silica microspheres containing both mesoporous and macroporous compartments as the support. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801258DOI Listing
March 2019
1 Read

Establishment of pressurized liquid extraction followed by HPLC-MS/MS method for the screening of adrenergic drugs, steroids, sedatives, colorants and antioxidants in swine feed.

J Sep Sci 2019 Mar 22. Epub 2019 Mar 22.

National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, P. R. China.

A facile and sensitive multi-residue detection approach of pressurized liquid extraction following high-performance liquid chromatography tandem mass spectrometry was established to detect the residues of adrenergic drugs, steroids, sedative, colorant and antioxidant in feed. The conditions employed for pressurized liquid extraction involved acetonitrile/ethyl acetate (1:1, v/v) as the extracting solvent, the temperature 80°C, two cycles and a static time of 10 min. The extraction was followed by a solid-phase extraction clean-up step. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801001DOI Listing

Multi-residue analysis of 44 pharmaceutical compounds in environmental water samples by solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry.

J Sep Sci 2019 Mar 18. Epub 2019 Mar 18.

CNRS/Univ Pau & Pays Adour/E2S UPPA, Institut Des Sciences Analytiques Et De Physicochimie Pour L'environnement Et Les Materiaux-MIRA, Anglet, France.

A solid-phase extraction combined with a liquid chromatography-tandem mass spectrometry analysis has been developed and validated for the simultaneous determination of 44 pharmaceuticals belonging to different therapeutic classes (i.e., antibiotics, anti-inflammatories, cardiovascular agents, hormones, neuroleptics, and anxiolytics) in water samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801214DOI Listing

In situ ionic liquid dispersive liquid-liquid microextraction combined with ultra high performance liquid chromatography for determination of neonicotinoid insecticides in honey samples.

J Sep Sci 2019 Mar 14. Epub 2019 Mar 14.

Yunnan Food Safety Research Institute, Kunming University of Science and Technology, Kunming, P. R. China.

An efficient in situ ionic liquid dispersive liquid-liquid microextraction followed by ultra-performance liquid chromatography was developed to determine four neonicotinoid insecticides in wild and commercial honey samples. In this method, a hydrophobic ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate, formed by in situ reaction between potassium hexafluorophosphate and 1-butyl-3-methylimidazolium bromide in sample solution, was used as the extraction solvent. In comparison with the traditional dispersive liquid-liquid microextraction method, the developed method required no dispersive solvent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801263DOI Listing
March 2019
2 Reads

Simultaneous high-performance liquid chromatography with tandem mass spectrometry quantification of six bioactive components in rat plasma after oral administration of Yougui pill.

J Sep Sci 2019 Mar 14. Epub 2019 Mar 14.

School of Traditional Chinese Medicine, Beijing Key Lab of TCM Collateral Disease Theory Research, Capital Medical University, Beijing, P. R. China.

Yougui pills are a classic Chinese medicine that shows significant effects on nerve regeneration and neuroprotection in modern pharmacological studies. With a complex formula, Yougui pills have faced significant challenges in the fields of bioanalysis and pharmacokinetics in animals and human studies. In the present study, a specific and accurate high-performance liquid chromatography with tandem mass spectrometry method was developed and validated for the quantitative determination of the six bioactive components in rat plasma after oral administration of Yougui pills. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201800772DOI Listing
March 2019
2 Reads

Characterization of chemical constituents and identification of absorbed components and metabolites in rat plasma of Fu-Ke-Zai-Zao pills by ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry.

J Sep Sci 2019 Mar 8. Epub 2019 Mar 8.

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China.

Fu-Ke-Zai-Zao pills, the famous traditional Chinese medicine formula, composed of 42 medicinal herbs, have been widely used to treat various gynecological diseases. However, the chemical constituents and metabolic profiling of Fu-Ke-Zai-Zao pills remain largely unknown, which hampers improvement of the quality control and pharmacological elucidation of this formula. In the present study, a sensitive and selective ultra high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry method was developed to separate and identify the comprehensive chemical constituents of Fu-Ke-Zai-Zao pills. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801161DOI Listing

The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers?

J Sep Sci 2019 Mar 8. Epub 2019 Mar 8.

School of Pharmacy, National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control, Shenyang Pharmaceutical University, Shenyang, China.

Insomnia, depression, and Alzheimer's disease are all neurodegenerative diseases and are associated with the levels of steroid hormones. To investigate the internal connection and difference of steroid hormones among these three diseases and distinguish them from the perspective of biomarkers, an easy, quick, and efficient high-performance liquid chromatography with tandem mass spectrometry method was established and validated to determine six steroid hormones simultaneously in rat serum. The separation was accomplished on a SHIM-PACK XR-ODS chromatographic column with 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801298DOI Listing
March 2019
1 Read

Screening and isolation of cyclooxygenase-2 inhibitors from the stem bark of Phellodendron amurense Ruprecht by ultrafiltration with liquid chromatography and tandem mass spectrometry, and complex chromatography.

J Sep Sci 2019 Mar 6. Epub 2019 Mar 6.

Central Laboratory, Changchun Normal University, Changchun, P. R. China.

Nonsteroidal anti-inflammatory drugs appear to reduce the risk of developing cancer. One mechanism through which nonsteroidal anti-inflammatory drugs act to prevent carcinogenesis is inhibition of the activity of the enzyme cyclooxygenase-2. The cyclooxygenase-2 inhibitors are widely used to reduce the risk of developing cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801262DOI Listing

Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold-stagnation and blood-stasis primary dysmenorrhoea after the administration of Leonurus japonicus houtt electuary.

J Sep Sci 2019 Mar 6. Epub 2019 Mar 6.

School of pharmacy, China Medical University, Shenyang, P. R. China.

Leonurus japonicus houtt, a well-known herb of traditional Chinese medicine, is widely used to treat gynaecological diseases. In this study, a rapid and sensitive liquid chromatography with tandem mass spectrometry method for simultaneously quantifying leonurine and stachydrine, the two main bioactive components in Leonurus japonicus houtt, was developed and validated. Plasma samples were prepared by protein precipitation with acetonitrile and separation by a Hewlett Packard XDB-C8 column (150 × 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801257DOI Listing
March 2019
3 Reads

Durable molybdenum oxide coated solid-phase microextraction fiber for highly selective and efficient extraction of polycyclic aromatic hydrocarbons in water.

J Sep Sci 2019 Mar 6. Epub 2019 Mar 6.

School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, P. R. China.

A bonding method was developed for coating molybdenum oxides onto a steel wire substrate, which was used as a solid-phase microextraction fiber, was coupled with gas chromatography. Based on the characterization, it is found that the as-prepared molybdenum oxides material contained a nanobelt structure with a uniform size and good dispersibility. In addition, there were a large number of small protrusions on the surface of the nanobelts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801280DOI Listing
March 2019
1 Read

Clay-Na as a sorbent for the extraction of anti-inflammatory compounds in water samples.

J Sep Sci 2019 Mar 6. Epub 2019 Mar 6.

Laboratory of Application Chemistry to the Resources and Natural Substances and the Environment (LACReSNE), Faculty of Science of Bizerte, Zarzouna, Bizerte, Tunisia.

In this work, clay-Na particles are used as the adsorbent for the solid-phase extraction of acidic compounds. The novel sorbent under study is based on high-specific surface area, cation-exchange capacity designed specifically to offer ion-exchange properties with the goal being to selectively extract a group of acidic compounds. The effects of the extraction parameters including extraction elution solvent, sample volume and pH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801251DOI Listing
March 2019
2 Reads

Analysis of fentanyl derivatives by ultra high performance liquid chromatography with diode array ultraviolet and single quadrupole mass spectrometric detection.

J Sep Sci 2019 Mar 4. Epub 2019 Mar 4.

George Washington University Department of Forensic Sciences, NW, Washington, DC, USA.

Fentanyl has become pervasive as a drug of abuse and as adulterant in seized drugs. Positional isomers analyzed by gas chromatography with mass spectrometry can follow the same fragmentation pathway and therefore may not be differentiated. Additionally, electron ionization leads to lack of discernible molecular ion for most fentanyl related compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801098DOI Listing
March 2019
3 Reads

Ionic liquid vortex-simplified matrix solid-phase dispersion for the simultaneous determination of terpenoids, crocins, quinic acid derivatives and flavonoids in Gardeniae fructus by UHPLC.

J Sep Sci 2019 Mar 3. Epub 2019 Mar 3.

Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.

A novel ionic-liquid-based vortex-simplified matrix solid-phase dispersion method using 2,6-dimethyl-β-cyclodextrin was established by ultra high performance liquid chromatography coupled with a photodiode array detector. 2,6-Dimethyl-β-cyclodextrin was first used as a promising adsorbent in this proposed method for simultaneous determination of eight compounds in Gardeniae fructus. These compounds are terpenoids (geniposidic acid, genipin-1-β-D-gentiobioside, geniposide, 8-o-acetyl shanzhiside methyl ester), crocins (crocin-I, crocin-II), quinic acid derivatives (chlorogenic acid), and flavonoids (isoquercitrin), respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801354DOI Listing
March 2019
7 Reads

Magnetic mesoporous nanoparticles modified with poly(ionic liquids) with multi-functional groups for enrichment and determination of pyrethroid residues in apples.

J Sep Sci 2019 Mar 3. Epub 2019 Mar 3.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, P. R. China.

Considering that the determination of pyrethroid residues is of value for the safety of food, a new poly(ionic liquid)-functionalized magnetic mesoporous nanoparticle was designed and used as an adsorbent in magnetic solid-phase extraction for the enrichment of eight pyrethroids. The porous structure and large surface area of the mesoporous silica shell endow the adsorbent with abundant binding sites. In contrast to the reported poly(ionic liquids) with only one kind of functional group in the cationic part, the new poly(ionic liquids) with mixed cyano and phenyl groups in cationic part matched the chemical structure of the analytes to improve extraction efficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900038DOI Listing
March 2019
4 Reads

Ionic liquids as mobile phase additives for determination of thiocyanate and iodide by liquid chromatography.

J Sep Sci 2019 Mar 1. Epub 2019 Mar 1.

Heilongjiang Province Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, P. R. China.

An analytical method was developed for the simultaneous determination of thiocyanate and iodide by reversed-phase liquid chromatography with UV detection using imidazolium ionic liquids as mobile phase additives. The chromatographic behaviors of the two anions on a C column were studied and compared with four types of reagents including imidazolium ionic liquids, pyridinium ionic liquids, 4-aminophenol hydrochloride and tetrabutylammonium as mobile phase additives. The effects of the concentrations of imidazolium ionic liquids, organic solvents and detection wavelength on separation and detection of the anions were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201801277DOI Listing
March 2019
5 Reads

LC method for the direct and simultaneous determination of four major furan derivatives in coffee grounds and brews.

J Sep Sci 2019 Feb 28. Epub 2019 Feb 28.

Institute of Biochemistry, Graz University of Technology, Graz, Austria.

The simultaneous quantification of two potential genotoxic hydroxymethyl furan derivatives in coffee (furfuryl alcohol and 5-hydroxymethylfurfural) alongside their carboxylic acid derivatives (2-furoic acid and 5-hydroxymethyl furoic acid, respectively) was carried out. Their extraction from ground roasted coffee using sonication, simple shaking or heat-assisted shaking lead to similar results. A minimum of 97. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201900061DOI Listing
February 2019
1 Read

A practicable strategy for enrichment and separation of four minor flavonoids including two isomers from barley seedlings by macroporous resin column chromatography, medium-pressure LC, and high-speed countercurrent chromatography.

J Sep Sci 2019 Feb 27. Epub 2019 Feb 27.

Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining, P. R. China.

Separation of minor compounds especially with similar polarities and structures from complex samples is a challenging work. In the present study, an efficient method was successfully established by macroporous resin column chromatography, medium-pressure liquid chromatography, and high-speed countercurrent chromatography for separation of four minor flavonoids from barley seedlings. Macroporous resin column chromatography and medium-pressure liquid chromatography were used for enrichment of these four flavonoids. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jssc.201801324
Publisher Site
http://dx.doi.org/10.1002/jssc.201801324DOI Listing
February 2019
6 Reads

A novel strategy to utilize ethylene glycol-ionic liquids for the selective precipitation of polysaccharides.

J Sep Sci 2019 Feb 27. Epub 2019 Feb 27.

Department of Chemistry, Zhejiang University, Hangzhou, P. R. China.

In the present work, three hydrophilic ionic liquids based on the combination between imidazolium cations attached with ethylene glycol polymers of various lengths and hexafluorophosphate anion were designed and synthesized for the separation of polysaccharides. By employing dextran 100 kDa as model compound, the effects of ionic liquid content, solvent/anti-solvent volume, and temperature on its recovery efficiency were investigated systematically. The ability of these ionic liquids to precipitate dextran 100 kDa, increases with the elongation of ethylene glycol polymer chain. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jssc.201801297
Publisher Site
http://dx.doi.org/10.1002/jssc.201801297DOI Listing
February 2019
5 Reads

Protein A chromatography: Challenges and progress in the purification of monoclonal antibodies.

J Sep Sci 2019 Feb 27. Epub 2019 Feb 27.

Tecnologico de Monterrey, School of Engineering and Science, Monterrey, NL, Mexico.

Antibodies for therapeutic use are being continuously approved and their demand has been steadily growing. As known, the golden standard for monoclonal antibody (mAb) purification is Protein A affinity chromatography, a technology that has gained high interest because of its great performance and capabilities. The main concerns are the elevated resins costs and their limited lifetime compared to other resins (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jssc.201800963DOI Listing
February 2019
1 Read