6,645 results match your criteria Journal of separation science[Journal]


The utility of statistical moments in chromatography using trapezoidal and Simpson's rules of peak integration.

J Sep Sci 2019 Feb 16. Epub 2019 Feb 16.

Department of Chemistry & Biochemistry, University of Texas at Arlington, Texas.

Modern chromatographic data acquisition software often behave as black boxes where the researchers have little control over the raw data processing. One of the significant interests of separation scientists is to extract physico-chemical information from chromatographic experiments and peak parameters. In addition, column developers need the total peak shape analysis to characterize the flow profile in chromatographic beds. Read More

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http://dx.doi.org/10.1002/jssc.201801131DOI Listing
February 2019

Recent strategies to enhance the performance of polymer monoliths for analytical separations.

J Sep Sci 2019 Feb 15. Epub 2019 Feb 15.

Australian Centre for Research on Separation Science (ACROSS), School of Natural Sciences-Chemistry, University of Tasmania, Hobart, TAS, Australia.

This review summarizes recent development made in the incorporation of functional materials into organic polymer monoliths, together with new monolithic forms and formats, which enhance their application as supports and stationary phase materials for sample preparation and chromatographic separations. While polymer monoliths are well known supports for the separation of large molecules, recent development have been made to improve their features for the separation of small molecules. The selectivity and performance of organic polymer monoliths has been improved by the incorporation of different materials, such as metal-organic frameworks, covalent organic frameworks, or other types of nanostructured materials (carbon nanohorns, nanodiamonds, polyoxometalates, layered double hydroxides, or attapulgite). Read More

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http://dx.doi.org/10.1002/jssc.201801126DOI Listing
February 2019

Magnetic solid phase extraction of benzoylurea insecticides in tea samples with Fe O -hyperbranched polyester magnetic composite as sorbent.

J Sep Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Applied Chemistry, College of Science, China Agricultural University,, Beijing, China.

In this work, a method for the analysis of benzoylurea insecticides, including hexaflumuron, flufenoxuron, lufenuron and chlorfluazuron, in tea samples by HPLC with Fe O - hyperbranched polyester nanocomposite as the adsorbent for magnetic solid-phase extraction was developed. The magnetic nanocomposite was prepared and characterized by infrared spectroscopy, vibrating sample magnetometry and scanning electron microscopy. The as-prepared nanocomposite was used as the sorbent for extraction and preconcentration of pesticide residues in tea samples. Read More

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http://dx.doi.org/10.1002/jssc.201801159DOI Listing
February 2019

Identification and Characterization of Forced Degradation Products and Stability-indicating Assay for Notoginsenoside Fc by Using UHPLC-Q-TOF-MS and UHPLC-MS/MS: Insights into Stability Profile and Degradation Pathways.

J Sep Sci 2019 Feb 15. Epub 2019 Feb 15.

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Shanghai, China.

Notoginsenoside Fc (NGFc), a protopanaxadiol-type saponin, shows multi-pharmacological activities. Chemical stability evaluation plays a crucial role in drug development. In this study, the forced degradation behavior of NGFc was investigated under hydrolytic and oxidative conditions. Read More

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http://dx.doi.org/10.1002/jssc.201801295DOI Listing
February 2019

Determination of chlorogenic acid, polyphenols and antioxidants in green coffee by thin-layer chromatography, effect-directed analysis and dot blot - comparison to HPLC and spectrophotometry methods.

J Sep Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Veterinary Microbiology, University of Life Sciences, Lublin, Poland.

The great prevalence of thin-layer chromatography over HPLC is connected with the possibility of analyzing many samples in parallel. Therefore, the method is often used in screening and/or effect directed analysis to compare composition and chemical/biological properties of many samples in one run. It was already proved, that high performance thin-layer chromatography, in many cases, can replace HPLC for quantitative analysis. Read More

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http://dx.doi.org/10.1002/jssc.201801174DOI Listing
February 2019

Determination of Residual Solvents in Isobutylboronic Acid: Masking Derivatization Improves Stability of GC Column.

J Sep Sci 2019 Feb 14. Epub 2019 Feb 14.

Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University, Olomouc, Czech Republic.

The masking derivatization was introduced for the determination of residual solvents in samples containing a volatile reactive matrix component(s). Isobutylboronic acid, used in the last step of Bortezomib synthesis, represents such a compound passing to the gas phase and deteriorating a chromatographic column during a headspace analysis. The masking derivatization with 1,8-diaminonaphthalene allowed a simple and straightforward conversion of isobutylboronic acid to a stable nonvolatile derivative and thus prevented GC column deterioration. Read More

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http://dx.doi.org/10.1002/jssc.201800968DOI Listing
February 2019

Extraction of antidepressant drugs in biological samples using alkanol-based nano structured supramolecular solvent microextraction followed by gas chromatography-mass spectrometric analysis.

J Sep Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran.

In the present study, a supramolecular solvent was formed from reverse micelle aggregates of octanol. The proposed supramolecular solvent was used for rapid extraction of some antidepressants drugs including amitriptyline, imipramine, desipramine, maprotiline, sertraline, and doxepin from biological samples. Alkanol-based supramolecular solvent have a unique array of physicochemical properties, making them a very attractive alternative to replace organic solvents in analytical extractions. Read More

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http://dx.doi.org/10.1002/jssc.201801152DOI Listing
February 2019

Preparation of A Stoichiometric molecularly imprinted polymers for Auramine O and application in solid phase extraction.

J Sep Sci 2019 Feb 13. Epub 2019 Feb 13.

CAS Key Laboratory of Coastal Environment Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, P. R. China.

This paper describes a stoichiometric approach to synthesis molecularly imprinted polymers specific for auramine O. Using the stoichiometric interaction in molecular imprinting no excess of binding sites is necessary and binding sites are only located inside the imprinted cavities. The free base of template was obtained to facilitate the interaction with the monomers. Read More

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http://dx.doi.org/10.1002/jssc.201801234DOI Listing
February 2019

Preparative mass-spectrometry profiling of minor concentrated metabolites in Salicornia gaudichaudiana Moq by high-speed countercurrent chromatography and off-line electrospray mass-spectrometry injection.

J Sep Sci 2019 Feb 11. Epub 2019 Feb 11.

Institute of Food Chemistry, Technische Universität Braunschweig, Braunschweig, Germany.

Salicornia species have just been introduced to the European market as a vegetable named 'samphire', 'green asparagus' or 'sea asparagus'. Due to its increasing attention, and associated value, minor compounds of Salicornia gaudichaudiana Moq were investigated. The use of countercurrent chromatography and mass spectrometry enabled the search for known, as well as potentially novel natural products. Read More

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http://dx.doi.org/10.1002/jssc.201801195DOI Listing
February 2019

On-site sampling of inorganic contamination on the metal surface and analysis with capillary electrophoresis.

J Sep Sci 2019 Feb 11. Epub 2019 Feb 11.

Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry &Chemical Biology, Tsinghua University, Beijing, China.

Pipes are the primary structural elements used for transporting fluid in various industries. The most common damage mechanism is corrosion, which occurs in pipes surface of turbine. The corrosive compounds for pipes are inorganic ion (Na , Cl , NH , NO , et al. Read More

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http://dx.doi.org/10.1002/jssc.201800916DOI Listing
February 2019

A method based on precolumn derivatization and ultraperformance liquid chromatography high resolution mass spectrometry for the simultaneous determination of phthalimide and phthalic acid in tea.

J Sep Sci 2019 Feb 11. Epub 2019 Feb 11.

Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, China.

Phthalimide can be formed from either degradation of folpet and phosmet, or reaction of phthalic anhydride with primary amino groups. Consequently, the sum of phthalimide and folpet, expressed as folpet-residue definition, is highly prone to false-positive levels of folpet in tea. An analytical method is thus urgently needed to investigate the residue level and source of phthalimide in tea. Read More

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http://dx.doi.org/10.1002/jssc.201801128DOI Listing
February 2019

A hierarchical screening method for detection of illegal adulterants in Fur seal ginseng pills by profiling analysis of HPLC multi-dimensional fingerprints.

J Sep Sci 2019 Feb 11. Epub 2019 Feb 11.

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.

A novel method for hierarchical screening of illegal adulterants in Fur seal ginseng pills products was developed by multi-dimensional fingerprint profiling analysis. fingerprint feature of the samples was acquired by HPLC analysis of 11 batches of samples with diode array detector and fluorescence detector, and then potential illegal adulterants including phosphodiesterase type-5 inhibitors, androgens, α receptor antagonists and yohimbine, were further separated at multiple wavelengths to reduce or remove interferences from sample matrix for highlight their chromatographic characteristics. Accordingly, a hierarchical screening strategy was designed by first-order and second-order fingerprints combined with spectral examination to achieve high accuracy and reliability. Read More

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http://dx.doi.org/10.1002/jssc.201900003DOI Listing
February 2019
2.737 Impact Factor

Determination of several synthetic cathinones and an amphetamine-like compound in urine by gas-chromatography/mass spectrometry. Method validation and application to real cases.

J Sep Sci 2019 Feb 11. Epub 2019 Feb 11.

Centro Regionale Antidoping e di Tossicologia "A. Bertinaria", 10043, Orbassano, Turin, Italy.

Most routine practices for drugs-of-abuse testing do not include screening procedures for new psychoactive substances, despite their increasing diffusion, preventing clear knowledge of the real consumption of these drugs in the populations. To make up for this shortcoming, a GC-MS method was developed for the simultaneous determination of 18 synthetic cathinones and one amphetamine-like compound in human urine. The sample preparation was based on liquid-liquid extraction under alkaline condition followed by derivatization with trifluoroacetic anhydride. Read More

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http://dx.doi.org/10.1002/jssc.201801249DOI Listing
February 2019

Comparative analysis of main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma.

J Sep Sci 2019 Feb 7. Epub 2019 Feb 7.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, P. R. China.

In this study, a rapid and highly sensitive ultra performance liquid chromatography-triple quadrupole mass spectrometer method with the mobile phases of acetonitrile and 0.1% aqueous formic acid was established and successfully applied to comparatively analyze main active components after their compatibility. Besides, the effects of Scutellariae Radix, Coptidis Rhizoma and combined extracts on type 2 diabetic rats induced by high-fat diet along with low dose of streptozocin were investigated. Read More

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http://dx.doi.org/10.1002/jssc.201801204DOI Listing
February 2019

Application of magnetized MOF-74 to phthalate esters extraction from Chinese liquor.

J Sep Sci 2019 Feb 8. Epub 2019 Feb 8.

College of Science, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, P.R. China.

In this study, magnetized MOF-74 (Ni) was prepared using an ultrasound-assisted synthesis method. This novel functional magnetic adsorbent was characterized using various techniques. Using the prepared material as adsorbents, a magnetic solid-phase extraction method coupled with HPLC was proposed for determining four phthalate esters in Chinese liquor samples. Read More

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http://dx.doi.org/10.1002/jssc.201801244DOI Listing
February 2019

Electrospun metal-organic framework/polyacrylonitrile composite nanofibrous mat as a microsorbent for extraction of tetracycline residue in human blood plasma.

J Sep Sci 2019 Feb 7. Epub 2019 Feb 7.

School of Chemistry, College of Science, University of Tehran, Tehran, Iran.

A new composite nanofiber of polyacrylonitrile doped with copper benzene-1,3,5-tricarboxylate metal-organic framework was fabricated by electrospinning and used as a microsorbent in solid phase extraction of trace tetracycline. The chemical structure of adsorbent was studied by X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, Brunauer-Emmett-Teller surface area analysis and Barrett-Joyner-Halenda pore size and volume analysis techniques. The significant parameters of the method including desorption solvent kind and volume, adsorbent mass, pH, and salt percentage were investigated. Read More

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http://dx.doi.org/10.1002/jssc.201801305DOI Listing
February 2019

Determination of estrone and 17α-ethinylestradiol in digested sludge by ultrasonic liquid extraction and high-performance liquid chromatography with fluorescence detection.

J Sep Sci 2019 Jan 31. Epub 2019 Jan 31.

CESAM & Department of Environment and Planning, University of Aveiro, Aveiro, Portugal.

Estrone, 17β-estradiol and 17α-ethinylestradiol are increasingly recognised as important micropollutants to be monitored in wastewater treatment plants. These estrogens are retained onto sludge due to their high adsorption and since they are largely used in land applications, the monitoring of these chemicals in sludge samples is of great importance. This study describes a method for the determination of estrone and 17α-ethinylestradiol in fresh sludge samples. Read More

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http://dx.doi.org/10.1002/jssc.201801114DOI Listing
January 2019
1 Read

Investigation of dynamic accumulation and regularity of nine glycosides and saccharides in Rehmannia glutinosa by rapid quantitative analysis technology.

J Sep Sci 2019 Jan 31. Epub 2019 Jan 31.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, State Administration of traditional Chinese medicine, Traditional Chinese medicine Resource Recycling, Nanjing University of Chinese Medicine, Nanjing, China.

In the process of planting and harvesting of Rehmannia glutinosa, only the underground part is used, and a large number of stems and leaves that are considered non-medicinal parts are usually discarded. Recent studies have shown that the chemical components in the leaves are similar to those identified in the roots. In this study, we selected leaves and roots from Rehmannia glutinosa at different growth stages and leaves from different cultivation regions to investigate the dynamic accumulation of 3 kinds of glycosides (catalpol, acteoside and ajugol), 6 kinds of carbohydrates (rhamnose, fructose, sucrose, melibiose, stachyose, and verbascose) and acidic and neutral polysaccharides via rapid quantitative analysis technology, including ultra-performance liquid chromatography triple quadrupole tandem mass spectrometry, HPLC and UV. Read More

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http://dx.doi.org/10.1002/jssc.201801185DOI Listing
January 2019
1 Read

Ultrasensitive separation of methylprednisolone acetate using photo responsive molecular imprinting polymer incorporated polyester dendrimer-based on magnetic nano-particles.

J Sep Sci 2019 Jan 28. Epub 2019 Jan 28.

Tehran Chemie Pharmaceutical Co, Tehran, Iran.

This study introduced a developed approach for the use of polyester dendrimer during the imprinting process to raise the number of recognized sites in the polymer matrix and improve its identification ability. Photo-responsive molecular imprinting polymers were synthesized on modified magnetic nano-particles involving polyester dendrimer which uses the reactivity between allyl glycidyl ether and acrylic acid for the high-yielding assembly by surface polymerization. The photo responsive molecular imprinting polymers were constructed using methylprednisoloneacetate as the template, water-soluble azobenzene involving 5-[(4, 3-(methacryloyloxy) phenyl) diazenyl] dihydroxy aniline as the novel functional monomer, and ethylene glycol dimethacrylate as the cross-linker. Read More

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http://dx.doi.org/10.1002/jssc.201801093DOI Listing
January 2019
4 Reads

An in situ electrochemical fabrication of layered by layered graphenized graphite- polyaniline as a stable solid phase microextraction fiber coating for trace environmental analysis.

J Sep Sci 2019 Jan 25. Epub 2019 Jan 25.

Department of Chemistry, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.

A layered by layered graphenized graphite/ polyaniline coating was fabricated on commercial pencil lead substrate by an in situ facile, fast and efficient electrochemical procedure. The electrodeposited polyaniline film on surface confined graphene structure can integrate the advantages of the both layers that were used for solid phase microextraction. Effective experimental parameters in electrochemical production of graphene nanosheets and electropolymerization of aniline were optimized. Read More

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http://dx.doi.org/10.1002/jssc.201801200DOI Listing
January 2019

Design of selective molecularly imprinted sorbent for the optimized solid-phase extraction of S-pramipexole from the model multicomponent sample of human urine.

J Sep Sci 2019 Jan 25. Epub 2019 Jan 25.

Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.

The objective of this article was to design the selective molecularly imprinted sorbent dedicated to the solid-phase extraction of S-pramipexole from the complex matrix such as human urine. For that purpose, S-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole was used as the template acting as the structural analog of S-pramipexole and five various monomers were employed in the presence of ethylene glycol dimethacrylate to produce molecularly imprinted polymers. The binding capabilities of resulted polymers revealed that the highest imprinting effect was noted for polymer prepared from the itaconic acid. Read More

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http://dx.doi.org/10.1002/jssc.201801101DOI Listing
January 2019

Characterization of the multiple chemical components of Glechomae Herba using ultra high performance liquid chromatography coupled to quadrupole-time-of-flight tandem mass spectrometry with diagnostic ion filtering strategy.

J Sep Sci 2019 Jan 25. Epub 2019 Jan 25.

The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, P. R. China.

Glechomae Herba is a traditional Chinese medicine used for the treatment of urolithiasis, cholelithiasis, and urinary tract infections in China. Identification of chemical constituents is helpful to discover the potential active ingredients. However, this significant work is stymied by complex chemical constituents. Read More

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http://dx.doi.org/10.1002/jssc.201801212DOI Listing
January 2019
4 Reads

Molecularly imprinted solid-phase extraction method for the gas chromatographic analysis of organochlorine fungicides in ginseng.

J Sep Sci 2019 Jan 25. Epub 2019 Jan 25.

College of Resources and Environment Science, Jilin Agricultural University, Changchun, Jilin, P. R. China.

A highly selective molecularly imprinted solid-phase extraction coupled with gas chromatography method was developed for the simultaneous isolation and determination of four organochlorine fungicides (pentachloronitrobenzene, pentachloroaniline, methylpentachlorophenyl sulfide and hexachlorobenzene) in ginseng samples. A novel molecularly imprinted polymers with pentachloronitrobenzene as template was synthesized by precipitation polymerization employing butanone: N-heptane (6.5: 3. Read More

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http://dx.doi.org/10.1002/jssc.201800765DOI Listing
January 2019

Novel capsule phase microextraction in combination with high performance liquid chromatography with diode array detection for rapid monitoring of sulfonamide drugs in milk.

J Sep Sci 2019 Jan 24. Epub 2019 Jan 24.

Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Capsule phase microextraction is introduced herein for the first time to determine four sulfonamide residues in milk samples (sulfanilamide, sulfadiazine, sulfamethizole, and sulfathiazole). The technique eloquently integrates filtration and stirring mechanism into the extraction device, as such no filtration of the sample is needed prior to introducing the extraction device into the sample, and when placed on a magnetic stirrer, the device spins itself in order to diffuse the sample, resulting in faster extraction equilibrium. Microextraction capsules consist of three main parts; a magnet, a cellulose fiber substrate coated with high performance sol-gel hybrid organic-inorganic sorbent, and a porous membrane. Read More

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http://dx.doi.org/10.1002/jssc.201801283DOI Listing
January 2019
2.737 Impact Factor

Rapid analysis of pyridinoline and deoxypyridinoline in biological samples by liquid chromatography with mass spectrometry and a silica hydride column.

J Sep Sci 2019 Jan 24. Epub 2019 Jan 24.

Department of Chemistry, San Jose State University, San Jose, USA.

Pyridinoline and deoxypyridinoline crosslinks are biomarkers found in urine for collagen degradation in bone turnover. For the first time, a rapid, sensitive, and ion-pairing free method is described for the analysis of pyridinoline and deoxypyridinoline using ultra-high performance liquid chromatography with Cogent Diamond Hydride column and detection by Q Exactive hybrid quadrupole-orbitrap high resolution accurate mass spectrometry. The separation was achieved using both isocratic and gradient conditions and run time <5 min under isocratic conditions of 20% acetonitrile in water containing 0. Read More

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http://dx.doi.org/10.1002/jssc.201801292DOI Listing
January 2019
1 Read

Open-Tubular Capillary Electrochromatography for the Simultaenous Determination of Cadmium and Copper in Plants.

J Sep Sci 2019 Jan 24. Epub 2019 Jan 24.

INQUISAL, Department of Chemistry National University of San Luis, CONICET. Chacabuco y Pedernera. D5700BWS, San Luis, Argentina.

This paper discusses the separation and determination of cadmium and copper in plant samples such as Triticum durum (wheat) and Helianthus annuus (sunflower) using open tubular capillary electrochromatography with indirect detection. Before performing the analysis, the samples were digested by microwave assisted methods using HNO . Regarding the electrophoretic system, several experimental parameters were previously evaluated such as the capillary surface, mobile phase composition, buffer, pH and voltage applied. Read More

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http://dx.doi.org/10.1002/jssc.201800853DOI Listing
January 2019

A hybrid triazine-imine core-shell magnetic covalent organic polymer for analysis of pesticides in fruit samples by ultra high performance liquid chromatography with tandem mass spectrometry.

J Sep Sci 2019 Jan 25. Epub 2019 Jan 25.

School of Chemistry, Sun Yat-sen University, Guangzhou, China.

A novel hybrid triazine-imine core-shell magnetic covalent organic polymer with high adsorption capacity and excellent stability was fabricated by surface-assisted in situ growth technique. The composite possesses porous and extended π-conjugated system, and was applied as the magnetic sorbent for efficient enrichment and rapid separation of pesticides. A new analytical method for simultaneous determination of eight pesticides in fruit samples was developed by magnetic solid phase extraction combined with ultra high performance liquid chromatography and tandem mass spectrometry. Read More

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http://dx.doi.org/10.1002/jssc.201801299DOI Listing
January 2019

Facile synthesis of magnetic zinc metal-organic framework for extraction of N-containing heterocyclic fungicides from lettuce vegetable samples.

J Sep Sci 2019 Jan 24. Epub 2019 Jan 24.

Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Key Laboratory of Vegetables Quality and Safety Control, Ministry of Agriculture and Rural Affairs of China, Beijing, P. R. China.

We present a simple method for the fabrication of a magnetic amino-functionalized zinc metal-organic framework based on a magnetic graphene oxide composite. The resultant framework exhibited a porous 3D structure, high surface area and good adsorption properties for N-containing heterocyclic fungicides adsorption. The adsorption process and capacity indicated that the primary adsorption mechanism might be hydrogen bonding and π-π conjugation. Read More

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http://dx.doi.org/10.1002/jssc.201801169DOI Listing
January 2019

Tetra-proline-modified calix[4]arene-bonded silica stationary phase for simultaneous reversed-phase/hydrophilic interaction mixed-mode chromatography.

J Sep Sci 2019 Jan 24. Epub 2019 Jan 24.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.

A new water-soluble tetra-proline-modified calix[4]arene-bonded silica stationary phase was prepared straightforwardly by an indirect method and characterized by elemental analysis, energy dispersive Spectrometry, solid-state C NMR spectroscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. Due to the simultaneous introduction of polar tetra-proline and nonpolar calix[4]arene, the developed column possessing a double retention mode of reverse-phase liquid chromatography and hydrophilic interaction liquid chromatography. A series of hydrophobic and hydrophilic test samples, including nucleosides and nucleotides, amines, monosubstituted benzenes, chiral compounds, and phenols, were used to evaluate the developed stationary phase. Read More

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http://dx.doi.org/10.1002/jssc.201800967DOI Listing
January 2019
1 Read

Rapid characterization of the chemical constituents and rat metabolites of the Wen-Jing decoction by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

J Sep Sci 2019 Jan 23. Epub 2019 Jan 23.

Innovation Center of Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai, P. R. China.

The Wen-Jing decoction, a traditional Chinese medicine formula, has been used as a blood-activating and stasis-eliminating drug to treat gynaecological syndromes, such as dysmenorrhea, amenorrhea, and menstrual disorders. However, its pharmacodynamic material basis and mechanism of action have not been thoroughly elucidated to date. The goal of this study was to characterize and identify multiple constituents and metabolites in Wen-Jing decoction. Read More

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http://dx.doi.org/10.1002/jssc.201801020DOI Listing
January 2019
2 Reads
2.737 Impact Factor

Simultaneous detection of four flavonoids and two alkaloids in rat plasma by LC-MS/MS and its application to a comparative study of the pharmacokinetics between Abri Herba and Abri mollis Herba extract after oral administration.

J Sep Sci 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.

Abri Herba and Abri mollis Herba both were important members of the Leguminosae family in southwestern China. Abri mollis Herba was often used as Abri Herba due to their proximity, but there are few studies on pharmacokinetics to compare their main identical active compositions. A sensitive and selective high-performance liquid chromatography with tandem mass spectrometry method in the positive/negative electrospray ionization switching mode was developed and validated for the simultaneous analysis of four flavonoids and two alkaloids in rat plasma. Read More

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http://doi.wiley.com/10.1002/jssc.201801122
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http://dx.doi.org/10.1002/jssc.201801122DOI Listing
January 2019
8 Reads

A natural and renewable biosorbent phase as a low-cost approach in disposable pipette extraction technique for the determination of emerging contaminants in lake water samples.

J Sep Sci 2019 Jan 22. Epub 2019 Jan 22.

Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

This study proposes an efficient analytical methodology using a biosorbent (cork) as an extraction phase in disposable pipette extraction technique for the rapid determination of the emerging contaminants methyl paraben, ethyl paraben, benzophenone, 3-(4-methylbenzylidene) camphor and 2-(ethylhexyl)-4-(dimethylamino) benzoate in lake water samples using high-performance liquid chromatography with diode array detection. The optimized conditions were comprised of 800 μL of sample, three cycles of 30 s each for the extraction, pH 6, addition of 30% w/v of NaCl. For the desorption step, the optimized desorption conditions were achieved with 100 μL of a mixture comprised of 50% methanol and 50% acetonitrile v/v, using one cycle of 30 s. Read More

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http://dx.doi.org/10.1002/jssc.201801005DOI Listing
January 2019
1 Read

Fast fabrication of a hybrid monolithic column containing cyclic and aliphatic hydrophobic ligands via photo-initiated thiol-ene polymerization.

J Sep Sci 2019 Jan 22. Epub 2019 Jan 22.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.

Three monomers, octakis (3-mercaptopropyl) octasilsesquioxane, 1,2,4-trivinylcyclohexane and isophytol were employed to synthesize a novel monolithic stationary phase via photo-initiated thiol-ene click polymerization for reversed-phase liquid chromatography. Several factors such as porogenic system, reaction time and the molar ratio of functional groups were investigated in detail. The resulting poly(POSS-co-TVCH-co-isophytol) monolithic column exhibited suitable permeability for fast separation and outstanding thermal stability. Read More

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http://dx.doi.org/10.1002/jssc.201801033DOI Listing
January 2019

A LC-MS/MS method for simultaneous determination of seven alkaloids in rat plasma after oral administration of Phellodendri chinensis cortex extract and its application to a pharmacokinetic study.

J Sep Sci 2019 Jan 22. Epub 2019 Jan 22.

Key Laboratory of Chinese MateriaMedica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin, China.

A sensitive and rapid LC-MS/MS method has been developed for simultaneous determination of berberine (I), jateorhizine (II), palmatine (III), tetrahydropalmatine (IV), phellodendrine (V), protopine (VI) and columbamine (VII) in rat plasma after oral administration of Phellodendri chinensis cortex extraction. The plasmas were extracted by liquid-liquid extraction. The tandem mass spectrometric detection was performed in the multiple reaction monitoring mode in the positive ionization. Read More

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http://dx.doi.org/10.1002/jssc.201801018DOI Listing
January 2019
1 Read

Marinobufagenin extraction from Rhinella marina toad glands: Alternative approaches for a systematized strategy.

J Sep Sci 2019 Jan 22. Epub 2019 Jan 22.

Laboratory of Pharmaceutical Analysis, Faculty of medicine and pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium.

Marinobufagenin is a bufadienolide compound detected mainly in skin and parotoid gland secretions of Rhinella marina (L.) toad. Bufadienolides regulate the Na /K -ATPase pump by inhibiting the cardiotonic steroid dependent-site and act as cardiac inotropes with vasoconstrictive properties. Read More

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http://doi.wiley.com/10.1002/jssc.201800879
Publisher Site
http://dx.doi.org/10.1002/jssc.201800879DOI Listing
January 2019
6 Reads

Selective enrichment and quantification of okadaic acid in shellfish using an immunomagnetic-bead-based liquid chromatography with tandem mass spectrometry assay.

J Sep Sci 2019 Jan 22. Epub 2019 Jan 22.

Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, P. R. China.

Okadaic acid is a marine biotoxin that primarily occurs in shellfish and can cause diarrheic shellfish poisoning in humans. When analyzing biological samples using liquid chromatography with tandem mass spectrometry, the presence of complex matrices is a major issue. Thus, it is crucial to selectively and simply extract the target analyte from samples and minimize matrix effects simultaneously. Read More

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http://dx.doi.org/10.1002/jssc.201800875DOI Listing
January 2019

Application of characteristic fragment filtering with ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry for comprehensive identification of components in Schisandrae chinensis Fructus.

J Sep Sci 2019 Jan 22. Epub 2019 Jan 22.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

An integrated strategy of characteristic fragment filtering combined with target database screening based on ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry was proposed for comprehensive profiling of components in Schisandrae chinensis Fructus. The strategy consisted of following five steps: (1) Representative standards were analyzed by ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer for characteristic fragments and fragmentation rules of each structure type. (2) The raw data of 70% methanol extract was collected by ultra-high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry. Read More

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http://dx.doi.org/10.1002/jssc.201801203DOI Listing
January 2019
1 Read

Capillary electrophoresis integrated immobilized enzyme reactor for kinetic and inhibition assays of β-secretase as the Alzheimer's disease drug target.

J Sep Sci 2019 Jan 21. Epub 2019 Jan 21.

Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.

Capillary electrophoresis integrated immobilized enzyme reactors are becoming an increasingly popular alternative for enzyme kinetic and inhibition assays thanks to their unique set of features including cost effectiveness, repeated use of the enzyme, minuscule sample consumption, rapid analysis time and easy automation. In this work we present the development and application of a capillary electrophoresis integrated immobilized enzyme reactor based on magnetic particles for kinetic and inhibition studies of β-secretase, a key enzyme in the development of Alzheimer's disease and a promising drug target. We document the optimization of the immobilization procedure, characterization of immobilized β-secretase, optimization of a mutually compatible incubation protocol and separation method as well as the production of the capillary electrophoresis integrated immobilized enzyme reactor. Read More

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http://dx.doi.org/10.1002/jssc.201800947DOI Listing
January 2019
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Identification of flavonoids in Dendrobium huoshanense and comparison with those in allied species of Dendrobium by TLC, HPLC and HPLC coupled with electrospray ionization multi-stage tandem MS analyses.

J Sep Sci 2019 Jan 21. Epub 2019 Jan 21.

School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China.

Dendrobium huoshanense, a unique species in the genus Orchidaceae, is only found in China and is known as "mihu". Due to the lack of quality control, the use of D. huoshanense in the herbal market has been limited. Read More

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http://dx.doi.org/10.1002/jssc.201801021DOI Listing
January 2019
4 Reads

Organic polymer-based monolithic capillary columns and their applications in food analysisψ.

J Sep Sci 2019 Jan 21. Epub 2019 Jan 21.

Department of Chemistry, Oklahoma State University, Stillwater, OK, USA.

In recent years, the use of organic polymer monolithic capillary columns in separation science has gained popularity due to the fact that they are easy to fabricate and do not require retaining frits. These materials have been applied in different fields including foods, proteomics, and pharmaceuticals. The interest in food analysis still needs to develop in order to increase the sensitivity towards micro/nano-scale food applications for food samples of < 5 μg (e. Read More

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http://dx.doi.org/10.1002/jssc.201801051DOI Listing
January 2019

Applications of monolithic columns in gas chromatography and supercritical fluid chromatography.

J Sep Sci 2019 Jan 18. Epub 2019 Jan 18.

Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia.

Porous monoliths are well-known stationary phases in high-performance liquid chromatography and capillary electrochromatography. Contrastingly, their use in other types of separation methods such as gas or supercritical fluid chromatography is limited and scarce. In particular, very few studies address the use of monolithic columns in supercritical fluid chromatography. Read More

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http://doi.wiley.com/10.1002/jssc.201801071
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http://dx.doi.org/10.1002/jssc.201801071DOI Listing
January 2019
4 Reads

Combination of capillary electrophoresis and molecular modeling to study the enantiomer affinity pattern between β-blockers and anionic cyclodextrin derivatives in a methanolic and water background electrolyte.

J Sep Sci 2019 Jan 19. Epub 2019 Jan 19.

School of Stomatology and Medicine, Foshan University, Foshan, China.

In order to have deep insights into the mechanisms of enantiomer affinity pattern in both aqueous and non-aqueous systems, an approach combining capillary electrophoresis and molecular modeling was undertaken. A chiral β-blocker; acebutolol, was enantioseparated in aqueous capillary electrophoresis and non-aqueous capillary electrophoresis using two anionic β-cyclodextrin derivatives. The enantiomer affinity pattern of acebutolol was found to be opposite when an aqueous background electrolyte was replaced with non-aqueous background electrolyte in the presence of heptakis(2,3-di-O-acetyl-6-sulfo)-β-cyclodextrin but remained the same in the presence of heptakis(2,3-di-O-methyl-6-sulfo)-β-cyclodextrin. Read More

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http://dx.doi.org/10.1002/jssc.201800884DOI Listing
January 2019
1 Read

A green extraction material - natural cotton fiber for in-tube solid-phase microextraction.

J Sep Sci 2019 Jan 18. Epub 2019 Jan 18.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, P. R. China.

Natural cotton fiber was applied as a green extraction material for in-tube solid-phase microextraction. Cotton fibers were characterized by scanning electron microscope. A bundle of cotton fibers (685 mg, 20 cm) was directly packed into a polyetheretherketone tube (i. Read More

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http://dx.doi.org/10.1002/jssc.201801233DOI Listing
January 2019
1 Read

Ligand fishing of anti-neurodegenerative components from Lonicera japonica using magnetic nanoparticles immobilised with monoamine oxidase B.

J Sep Sci 2019 Jan 17. Epub 2019 Jan 17.

Chinese Academy of Sciences, Chengdu Institute of Biology, Chengdu, P. R. China.

In this work, monoamine oxidase B was immobilised onto magnetic nanoparticles to prepare a new type of affinity solid-phase extraction adsorbent, which was used to extract the possible anti-neurodegenerative components from the Lonicera japonica flower extracts. Coupled with high-performance liquid chromatography with mass spectrometry, two monoamine oxidase B ligands were fished-out and identified as isochlorogenic acid A and isochlorogenic acid C, which were found to be inhibitors of the enzyme for the first time, with similar half maximal inhibitory concentration values of 29.05 ± 0. Read More

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http://dx.doi.org/10.1002/jssc.201801255DOI Listing
January 2019
1 Read

Pressurized liquid extraction of cyclitols and sugars: optimization of extraction parameters and selective separation.

J Sep Sci 2019 Jan 17. Epub 2019 Jan 17.

Interdisciplinary Centre of Modern Technologies, Nicolaus Copernicus University, Wileńska, Toruń, Poland.

Cyclitols and sugars were obtained as a mixture from Medicago sativa L., in a comparative study by using maceration, and pressurized liquid extraction, as a modern and green extraction techniques. The influence of extraction parameters including: extraction temperature, time and number of cycles on the content of sugars and cyclitols was investigated based on response surface methodology. Read More

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http://dx.doi.org/10.1002/jssc.201801269DOI Listing
January 2019

Combination of a modified quick, easy, cheap, efficient, rugged, and safe extraction method with a deep eutectic solvent based microwave-assisted dispersive liquid-liquid microextraction: Application in extraction and preconcentration of multiclass pesticide residues in tomato samples.

J Sep Sci 2019 Jan 17. Epub 2019 Jan 17.

Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

In this study, a new two-step extraction procedure based on the combination of a modified quick, easy, cheap, effective, rugged, and safe extraction method with a deep eutectic solvent based microwave-assisted dispersive liquid-liquid microextraction has been developed for the extraction of multiclass pesticides in tomato samples before their analysis by gas chromatography with flame ionization detection. In this method, initially, an aliquot of tomato is crushed and diluted with deionized water. The mixture is then passed through a filter paper and its residue and aqueous phase are separated. Read More

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http://dx.doi.org/10.1002/jssc.201801107DOI Listing
January 2019
2 Reads

A liquid chromatography with tandem mass spectrometry method to simultaneously determinate chlorpyrifos, imidacloprid and imidacloprid metabolites in wheat.

J Sep Sci 2019 Jan 17. Epub 2019 Jan 17.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, P. R. China.

A liquid chromatography with tandem mass spectrometry method was developed and validated to simultaneously determine chlorpyrifos, imidacloprid, and imidacloprid metabolites in soil, wheat grain, and wheat straw matrices. Satisfactory linearity (R ≥ 0.9965) of the method was obtained for all analytes. Read More

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http://dx.doi.org/10.1002/jssc.201801163DOI Listing
January 2019

Separation of six compounds from pigeon pea leaves by elution-extrusion counter-current chromatography.

J Sep Sci 2019 Jan 17. Epub 2019 Jan 17.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.

A valid and reliable method was established to separate six compounds from pigeon pea leaves via elution-extrusion counter-current chromatography. A solvent system composed of n-hexane/methanol/formic acid aqueous solution with pH = 3 (10:6:4, v/v) was screened to achieve satisfactory isolation from the ethanol extract of pigeon pea leaves. Four compounds, 9. Read More

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http://doi.wiley.com/10.1002/jssc.201801111
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http://dx.doi.org/10.1002/jssc.201801111DOI Listing
January 2019
7 Reads

Determination of multi-class antibiotic residues in compost by microwave-enhanced accelerated solvent extraction and ultra performance convergence chromatography-tandem mass spectrometry.

J Sep Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Pharmacy, Liaoning cancer hospital, Shenyang, China.

This work reports the development and application of a multi-class compound analysis method for the determination of 20 antibiotic residues in compost. Samples were processed by microwave-enhanced accelerated solvent extraction at 120°C for 7.5 min. Read More

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http://dx.doi.org/10.1002/jssc.201801032DOI Listing
January 2019
2 Reads
2.737 Impact Factor

Graphene oxide-based molecularly imprinted polymers modified with β-cyclodextrin for selective extraction of di (2-ethylhexyl) phthalate in environmental waters.

J Sep Sci 2019 Jan 14. Epub 2019 Jan 14.

Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA, USA.

Graphene oxide based molecularly imprinted polymers modified with β-cyclodextrin were prepared as solid phase extraction column sorbents for specific recognition and sensitive detection of di (2-ethylhexyl) phthalate in water samples. The morphology and composition of synthesized sorbents were characterized by scanning electron microscopy, thermo-gravimetric analysis, Raman spectroscopy, and Fourier-transform infrared spectroscopy. The conditions affecting the performance of extraction procedures such as desorption solvent types and volume, sample pH and volume were investigated. Read More

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http://doi.wiley.com/10.1002/jssc.201801171
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http://dx.doi.org/10.1002/jssc.201801171DOI Listing
January 2019
4 Reads