4,412 results match your criteria Journal of psychiatric research[Journal]


Exploring the role of BDNF DNA methylation and hydroxymethylation in patients with obsessive compulsive disorder.

J Psychiatr Res 2019 Apr 6;114:17-23. Epub 2019 Apr 6.

University of Milan, Department of Biomedical and Clinical Sciences Luigi Sacco, Milano, Italy; CRC "Aldo Ravelli", University of Milan, Milano, Italy; Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA. Electronic address:

Obsessive-compulsive disorder (OCD) is a clinically heterogeneous neuropsychiatric condition associated with profound disability, whose susceptibility, stemming from genetic and environmental factors that intersect with each other, is still under investigation. In this perspective, we sought to explore the transcriptional regulation of Brain Derived Neurotrophic Factor (BDNF), a promising candidate biomarker in both development and etiology of different neuropsychiatric conditions, in peripheral blood mononuclear cells from OCD patients and healthy controls. In particular, we focused on BDNF gene expression and interrogated in depth DNA methylation and hydroxymethylation at gene promoters (exons I, IV and IX) in a sample of OCD patients attending a tertiary OCD Clinic to receive guidelines-recommended treatment, and matched controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.04.006DOI Listing

Speech production and disorganization in schizotypy: Investigating the role of cognitive and affective systems.

J Psychiatr Res 2019 Mar 24;114:11-16. Epub 2019 Mar 24.

Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, United States.

Diminished productivity and elevated disorganization have been detected in the speech of individuals with schizotypy. However, the underlying mechanisms for these disruptions are not well understood. Separate lines of research suggest potential contributions from cognitive and affective systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.023DOI Listing

Childhood maltreatment, vulnerability characteristics and adult incident common mental disorders: 3-year longitudinal data among >10,000 adults in the general population.

J Psychiatr Res 2019 Mar 30;113:199-207. Epub 2019 Mar 30.

Department of Psychiatry and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands.

Childhood maltreatment (CM) is a strong predictor of incident (first-onset and recurrent) mental disorders in adulthood. However, less is known about underlying mechanisms and moderators of these associations. This study examines to what extent vulnerability characteristics (low social support, negative life events, parental psychopathology, neuroticism, history and comorbidity of mental and physical health) contribute to the impact of CM on adult psychopathology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.029DOI Listing
March 2019
1 Read

Cerebrospinal fluid BDNF pro-peptide levels in major depressive disorder and schizophrenia.

J Psychiatr Res 2019 Mar 26;113:190-198. Epub 2019 Mar 26.

Biomedical Research Institute (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan; Graduate School of Frontier Bioscience, Osaka University, Suita 565-0871, Japan. Electronic address:

The role of brain-derived neurotrophic factor (BDNF) and its related molecules has been extensively studied in the context of psychiatric disorders. In the present study, we focused on the newly identified BDNF pro-peptide, which is generated together with mature BDNF by proteolytic processing of their precursor, proBDNF. Here, we report, for the first time, that BDNF pro-peptide is present in human cerebrospinal fluid (CSF) and quantifiable by western blotting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.024DOI Listing

TEMPORARY REMOVAL: Letter to the editor: Pharmacogenomic testing is not ready for general use in psychiatry.

J Psychiatr Res 2019 Apr 6. Epub 2019 Apr 6.

UPMC Health Plan, 600 Grant Street, 55th Floor, Pittsburgh, PA, 15219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.04.003DOI Listing

Tamoxifen has an anti-manic effect but not protect the brain against oxidative stress in an animal model of mania induced by ouabain.

J Psychiatr Res 2019 Mar 26;113:181-189. Epub 2019 Mar 26.

Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address:

Studies have suggested the involvement of oxidative stress in the physiopathology of bipolar disorder. Preclinical data have shown that PKC inhibitors may act as mood-stabilizing agents and protect the brain in animal models of mania. The present study aimed to evaluate the effects of Lithium (Li) or tamoxifen (TMX) on behavioral changes and oxidative stress parameters in an animal model of mania induced by ouabain (OUA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.020DOI Listing
March 2019
1 Read

Interplay between pro-inflammatory cytokines, childhood trauma, and executive function in depressed adolescents.

J Psychiatr Res 2019 Apr 1;114:1-10. Epub 2019 Apr 1.

University of Illinois at Chicago, Department of Psychiatry, USA.

Background: Pro-inflammatory cytokines have been linked to depression, early childhood trauma, and impairment in executive function in adults. Whether these links are present during adolescence, a time when vulnerability to depression is heightened, a point more proximal to childhood trauma, and a critical period of brain development, is not well understood.

Method: Serum levels of interleukin (IL)-6, IL-1β, and tumor necrosis factor alpha (TNF-α) were measured in 70 adolescents aged 12-17, including 40 with a DSM-IV depressive disorder (DEP), a sub-set (n = 22) of whom reported a history of childhood trauma (DEP-T), and 30 healthy controls (HCs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.030DOI Listing
April 2019
1 Read

The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF).

J Psychiatr Res 2019 Mar 22;113:125-136. Epub 2019 Mar 22.

Duke-NUS Medical School, Singapore; Duke University, Durham, NC, USA; Texas Tech University, Permian Basin, TX, USA.

There is considerable diversity in how treatment-resistant depression (TRD) is defined. However, every definition incorporates the concept that patients with TRD have not benefited sufficiently from one or more adequate trials of antidepressant treatment. This review examines the issues fundamental to the systematic evaluation of antidepressant treatment adequacy and resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.021DOI Listing
March 2019
1 Read

Exploring common changes after acute mental stress and acute tryptophan depletion: Resting-state fMRI studies.

J Psychiatr Res 2019 Apr 1;113:172-180. Epub 2019 Apr 1.

Department of Psychiatry, University of Connecticut School of Medicine, Farmington, USA. Electronic address:

Stress and low serotonin levels are important biological factors in depression and anxiety etiologies. Although studies indicate that low serotonin levels, stress, and other factors may interact in depression/anxiety psychopathology, few studies have investigated the potentially shared neural substrates. We conducted resting-state fMRI scans pre- and post-stress task, and under control and tryptophan depletion condition, to explore the common changes induced by acute mental stress (AMS) and acute tryptophan depletion (ATD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.025DOI Listing
April 2019
3 Reads
3.957 Impact Factor

Sex differences in the association of baseline c-reactive protein (CRP) and acute-phase treatment outcomes in major depressive disorder: Findings from the EMBARC study.

J Psychiatr Res 2019 Mar 20;113:165-171. Epub 2019 Mar 20.

Center for Depression Research and Clinical Care, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390-9119, TX, USA. Electronic address:

Peripheral inflammation is associated with poor response to antidepressant treatments. However, whether sex differentially affects this association remains unknown. Participants of Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) with baseline plasma samples were included in this study (n = 220; male n = 75, female n = 145). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223956193002
Publisher Site
http://dx.doi.org/10.1016/j.jpsychires.2019.03.013DOI Listing
March 2019
2 Reads

Elevated peripheral kynurenine/tryptophan ratio predicts poor short-term auditory memory in panic disorder patients.

J Psychiatr Res 2019 Apr 2;113:159-164. Epub 2019 Apr 2.

Laboratory of Panic & Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rua Ataulfo de Paiva 135 S. 609, 22440-901, Brazil.

Abnormalities in the kynurenine pathway (KP) have been implicated in the cognitive deficits of psychiatry disorders, possibly through cytokines that increase the activity of indoleamine-2,3 dioxygenase (IDO), a key enzyme for tryptophan-to-kynurenine conversion. Some studies on panic disorder (PD) have detected elevated cytokines in blood. We aimed to determine the extent to which elevated peripheral cytokine levels and kynurenine/tryptophan (kyn/tryp) ratio (1) are biological markers for PD patients and (2) are related to cognition in PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.027DOI Listing
April 2019
1 Read

A clinical model for identifying an inflammatory phenotype in mood disorders.

J Psychiatr Res 2019 Feb 10;113:148-158. Epub 2019 Feb 10.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; VA Palo Alto Health Care System, Palo Alto, CA, USA.

Increasingly, clinical research has found inflammatory correlates of psychiatric disorders, particularly mood symptomatology. Biological measures may provide greater precision in many cases and may capture clinically-relevant inflammatory signposts, such as central obesity risk, inflammation-associated co-morbid medical conditions, or proinflammatory lifestyle choices. In order to expand understanding of the role of inflammation in mood disorders, we propose a more inclusive clinical model for capturing an inflammatory phenotype of depression by identifying clinically-relevant inflammatory phenotypes grounded in biology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.005DOI Listing
February 2019
3 Reads

Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease.

J Psychiatr Res 2019 Mar 30;113:141-147. Epub 2019 Mar 30.

Center for Neurodegenerative Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100050, China. Electronic address:

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. It shares clinical and pathological features with other types of dementia, such as vascular dementia (VaD), Lewy body dementia (LBD), and frontotemporal dementia (FTD). We have hypothesized that there might be an overlapping molecular mechanism and genetic basis to the different types of dementia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.026DOI Listing

Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia.

J Psychiatr Res 2019 Mar 24;113:137-140. Epub 2019 Mar 24.

Department of Neurology, Ulm University, Ulm, Germany. Electronic address:

The overlapping symptoms of behavioural variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (such as depressive disorder, schizophrenia spectrum, and bipolar disorder) present a challenge for the differential diagnosis of bvFTD in middle and older-aged people. Neurofilaments are cytoskeletal proteins in the neurons, and several studies have reported elevated levels of neurofilament light chain (NfL) in cerebrospinal fluid of neurodegenerative as well as psychiatric disorders. The study aims to determine the utility of serum NfL levels as a biomarker to differentiate between bvFTD and psychiatric disorder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.019DOI Listing
March 2019
8 Reads
3.957 Impact Factor

Cognitive functioning as a predictor of response to comprehensive cognitive remediation.

J Psychiatr Res 2019 Mar 21;113:117-124. Epub 2019 Mar 21.

Department of Occupational Therapy, Boston University, Center for Psychiatric Rehabilitation, 940 Commonwealth Avenue, Boston, MA, 02215, USA. Electronic address:

Cognitive remediation is aimed at reducing cognitive impairments in severe mental illnesses such as schizophrenia, but little is known about whether severity of cognitive impairment predicts benefit from this intervention. To address this question, this study aggregated data from five randomized controlled trials (N = 300) of a standardized comprehensive, multimodal outpatient cognitive remediation program, the Thinking Skills for Work program, and evaluated whether baseline level of cognitive impairment differentially predicted improvement in cognitive functioning following cognitive remediation vs. usual services. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.012DOI Listing
March 2019
1 Read

Distinct resting state functional connectivity abnormalities in hoarding disorder and major depressive disorder.

J Psychiatr Res 2019 Mar 26;113:108-116. Epub 2019 Mar 26.

Anxiety Disorders Center, Institute of Living/Hartford Hospital, 200 Retreat Avenue, Hartford, CT, 06106, USA; Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA.

Emerging research suggests that hoarding disorder (HD) is associated with abnormal hemodynamic activity in frontal brain regions. Prior studies have not examined intrinsic network connectivity in HD during unstructured "resting state" fMRI. Furthermore, it remains unclear whether previously observed HD abnormalities might be better explained by the presence of other disorders frequently comorbid with HD, such as major depressive disorder (MDD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.022DOI Listing
March 2019
2 Reads

Physical activity for diabetes-related depression: A systematic review and meta-analysis.

J Psychiatr Res 2019 Mar 19;113:100-107. Epub 2019 Mar 19.

Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Japan. Electronic address:

Patients with diabetes have an increased risk of developing depression compared with non-diabetic individuals. We aimed to examine the utility of physical activity in the treatment of diabetes-related depression using a meta-analysis. Multiple databases were searched from inception to February 1, 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.014DOI Listing
March 2019
1 Read

Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients.

J Psychiatr Res 2019 Mar 21;113:90-99. Epub 2019 Mar 21.

Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen, Guangdong, China. Electronic address:

Background: To probe the differences of gut microbiota among major depressive disorder (MDD), bipolar disorder with current major depressive episode (BPD) and health participants.

Methods: Thirty one MDD patients, thirty BPD patients, and thirty healthy controls (HCs) were recruited. All the faecal samples were analyzed by shotgun metagenomics sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.017DOI Listing
March 2019
1 Read

Elucidating the glutamatergic processes underlying mismatch negativity deficits in early stage bipolar disorder and schizophrenia: A combined H-MRS and EEG study.

J Psychiatr Res 2019 Mar 24;113:83-89. Epub 2019 Mar 24.

Brain and Mind Centre, University of Sydney, Australia; Sunshine Coast Mind and Neuroscience - Thompson Institute, University of the Sunshine Coast, Maroochydore, Australia.

Impairments in mismatch negativity (MMN) in schizophrenia are well-established; these findings have been extended to show impairments at early illness stages and in bipolar disorder. A substantial literature supports MMN as an index of NMDA receptor output, however, few studies have conducted in vivo assessments to elucidate the neurochemical underpinnings of MMN. Sixty young (16-33 years) participants with bipolar disorder (n = 47) or schizophrenia (n = 13) underwent H-MRS and MMN assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.018DOI Listing
March 2019
1 Read

The dynamic course of peripartum depression across pregnancy and childbirth.

J Psychiatr Res 2019 Mar 15;113:72-78. Epub 2019 Mar 15.

Institute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Psychiatry, University of Helsinki, Helsinki, Finland; Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland.

Objective: Peripartum depression (PPD) pertaining to depression in pregnancy and postpartum is one of the most common complications around childbirth with enduring adverse effects on mother and child health. Although psychiatric symptoms may improve or worsen over time, relatively little is known about the course of PPD symptoms and possible fluctuations.

Methods: We applied a person-centered approach to examine PPD symptom patterns across pregnancy and childbirth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.016DOI Listing
March 2019
1 Read

Low-frequency rTMS is better tolerated than high-frequency rTMS in healthy people: Empirical evidence from a single session study.

J Psychiatr Res 2019 Mar 20;113:79-82. Epub 2019 Mar 20.

Monash Alfred Psychiatry Research Centre, The Alfred and the Central Clinical School, Monash University, Australia; Epworth Centre for Innovation in Mental Health, Epworth Healthcare, Australia.

Low-frequency and high-frequency repetitive transcranial magnetic stimulation (rTMS) are similarly efficacious for treatment-resistant depression. Low-frequency is posited to be better tolerated than high-frequency rTMS, however, this is not supported by empirical evidence to date. This study aimed to quantify and compare the tolerability of low-versus high-frequency rTMS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.015DOI Listing
March 2019
1 Read

Is improved fitness following a 12-week exercise program associated with decreased symptom severity, better wellbeing, and fewer sleep complaints in patients with major depressive disorders? A secondary analysis of a randomized controlled trial.

J Psychiatr Res 2019 Mar 15;113:58-64. Epub 2019 Mar 15.

Institute of Exercise Training and Sport Informatics, German Sport University Cologne, Cologne, Germany. Electronic address:

Major depressive disorder (MDD) is one of the most burdensome disorders worldwide. While exercise training in patients with MDD contributes to clinically relevant improvements in cardiorespiratory fitness, whether and to what degree changes in cardiorespiratory fitness impact depressive symptom severity has not yet been addressed systematically in prior research. The purpose of our study was threefold. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223956183099
Publisher Site
http://dx.doi.org/10.1016/j.jpsychires.2019.03.011DOI Listing
March 2019
4 Reads

Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia.

J Psychiatr Res 2019 Mar 8;113:51-57. Epub 2019 Mar 8.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Parkville, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, Victoria, Australia; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada; Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

A number of recent studies have suggested the ubiquitin proteasome system (UPS) in schizophrenia is dysfunctional. The purpose of this study was to investigate UBE2K, a ubiquitin-conjugating (E2) enzyme within the UPS that has been associated with psychosis symptom severity, in the blood and brain of individuals with schizophrenia. Whole blood and erythrocytes from 128 (71 treatment-resistant schizophrenia, 57 healthy controls) individuals as well as frozen dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) post-mortem samples from 74 (37 schizophrenia, 37 controls) individuals were obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.005DOI Listing
March 2019
1 Read
3.957 Impact Factor

GHQ score changes from teenage to young adulthood.

J Psychiatr Res 2019 Mar 11;113:46-50. Epub 2019 Mar 11.

ESRC Centre for Learning and Life Chances in Knowledge Economies and Societies, Institute of Education, University College London, London, WC1H 0AL, UK.

This study investigated the change in the General Health Questionnaire (GHQ-12) scores from teenage years to young adulthood using a large, nationally representative sample in the UK. It took account of socio-demographic variables, childhood intelligence, behavioural problems and self-esteem at teenage and educational qualifications in early adulthood. In total, 3942 cohort members had the complete data on GHQ at ages 16 and 30 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.006DOI Listing

Corrigendum to "Psychotic symptoms in youth with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) may reflect syndrome severity and heterogeneity" [J. Psychiatr. Res. 110 (2019) 93-102].

J Psychiatr Res 2019 Mar 18;113:45. Epub 2019 Mar 18.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States; Stanford Pediatric Acute-onset Neuropsychiatric Syndrome Clinic and Research Program at Lucile Packard Children's Hospital, Stanford University, Stanford, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.010DOI Listing

Response to letter to the editor: When does selection generate bias in clinical samples?

J Psychiatr Res 2019 Feb 22. Epub 2019 Feb 22.

School of Public Health, The University of Queensland, Herston, 4006, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.011DOI Listing
February 2019

Topographic deficits in sleep spindle density and duration point to frontal thalamo-cortical dysfunctions in first-episode psychosis.

J Psychiatr Res 2019 Mar 11;113:39-44. Epub 2019 Mar 11.

Department of Psychiatry, University of Pittsburgh, USA. Electronic address:

Sleep spindles are NREM sleep EEG oscillations, which are initiated within the thalamus and are regulated by thalamo-cortical circuits. Previous work from our and other research groups has shown marked spindle deficits in patients with schizophrenia (SCZ). However, the presence of spindle impairments at illness onset, including which parameters are most affected, their topographic characteristics, and their relationships with clinical symptoms have yet to be characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.009DOI Listing
March 2019
1 Read

Microduplications at the 15q11.2 BP1-BP2 locus are enriched in patients with anorexia nervosa.

J Psychiatr Res 2019 Jan 29;113:34-38. Epub 2019 Jan 29.

The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. Electronic address:

Microduplication at 15q11.2 have been reported in genetic association studies of schizophrenia and autism. Given the potential overlap in psychiatric symptoms of schizophrenia and autism with anorexia nervosa (AN), we were inspired to test the association of this CNV locus with the genetic susceptibility of AN using ParseCNV, a highly quality controlled CNV pipeline developed by our group. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223956183102
Publisher Site
http://dx.doi.org/10.1016/j.jpsychires.2019.01.021DOI Listing
January 2019
3 Reads

Adjunctive ondansetron for schizophrenia: A systematic review and meta-analysis of randomized controlled trials.

J Psychiatr Res 2019 Mar 5;113:27-33. Epub 2019 Mar 5.

Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address:

The serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor has been implicated in the pathogenesis of schizophrenia. This meta-analysis of randomized controlled trials (RCTs) examined the efficacy and safety of adjunctive ondansetron, a potent 5-HT3 receptor antagonist, in the treatment of schizophrenia. Only RCTs examining adjunctive ondansetron for schizophrenia were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.024DOI Listing
March 2019
1 Read

Brain response features during forced break could predict subsequent recovery in internet gaming disorder: A longitudinal study.

J Psychiatr Res 2019 Mar 9;113:17-26. Epub 2019 Mar 9.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Department of Child Study Center, Yale University School of Medicine, New Haven, CT, USA; Connecticut Mental Health Center, New Haven, CT, USA.

Although internet gaming disorder (IGD) is associated with negative health measures, individuals may recover without professional intervention. Exploring neural features associated with natural recovery may provide insights into how best to promote health among people with IGD. Seventy-nine IGD subjects were scanned when they were performing cue-craving tasks before and after gaming was interrupted with a forced break. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.003DOI Listing

Health benefits of a physical exercise program for inpatients with mental health; a pilot study.

J Psychiatr Res 2019 Mar 8;113:10-16. Epub 2019 Mar 8.

Psychobiology Research Laboratory, Mazor Mental Health Center, Akko, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel. Electronic address:

The positive effect of exercise on human health and the relationship between physical activity, health, and wellbeing are well studied and extensively documented in the literature. However, considerably less attention is devoted to the impact of exercise on mental health and wellbeing for people experiencing a mental illness, in general, and in particular for inpatients in the mental health care system. Here, we determine the clinical feasibility and effects of short-term (up to three months) vs long-term (up to six months) group-based exercise program for inpatients with chronic mental health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.002DOI Listing

Recall accuracy for the symptoms of a major depressive episode among clinical trial participants.

J Psychiatr Res 2019 Mar 8. Epub 2019 Mar 8.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA; Department of Psychology, Emory University, Atlanta, GA, USA.

For patients with major depressive disorder (MDD), approaches to treatment differ for those with a single versus recurrent episodes. Based on studies of community samples, however, accuracy is low for identifying past episodes. Recall accuracy among clinical samples with a well-defined major depressive episode (MDE) has not been examined previously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.008DOI Listing

Glucose-6-phosphate dehydrogenase activity in bipolar disorder and schizophrenia: Relationship to mitochondrial impairment.

J Psychiatr Res 2019 May 5;112:99-103. Epub 2019 Mar 5.

University of Maryland School of Medicine, Department of Psychiatry, 22 S. Greene St, Baltimore, MD, 21201, USA. Electronic address:

Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway that is essential to maintaining cellular redox balance. G6PD is especially plentiful in brain, and its deficiency has been linked to mood and psychotic disorders. We measured G6PD activity spectrophotometrically in four groups of 15 parietal somatosensory association cortex [Brodmann area (BA) 7] tissue samples (N = 60) from individuals with bipolar disorder (BPD); nonpsychotic unipolar major depression (UPD); schizophrenia (SCZ), and controls without psychiatric illness (CON). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.03.004DOI Listing
May 2019
2 Reads

Alteration of miRNA-mRNA interactions in lymphocytes of individuals with schizophrenia.

J Psychiatr Res 2019 May 5;112:89-98. Epub 2019 Mar 5.

School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia; Centre for Brain and Mental Health Research, Hunter Medical Research Institute, New Lambton, New South Wales, Australia. Electronic address:

The aetiology of schizophrenia is complex, heterogeneous, and involves interplay of many genetic and environmental influences. While significant progress has been made in the understanding the common heritable component, we are still grappling with the genomic encoding of environmental risk. One class of molecule that has tremendous potential is miRNA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.023DOI Listing
May 2019
2 Reads

Attentional bias and childhood maltreatment in clinical depression - An eye-tracking study.

J Psychiatr Res 2019 May 1;112:83-88. Epub 2019 Mar 1.

Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Semmelweisstr. 10, 04103, Leipzig, Germany. Electronic address:

Major depressive disorder (MDD) has been found to be associated with biased attention to emotional stimuli: increased attention for dysphoric information and/or decreased attention for positive information compared to healthy individuals. A history of childhood maltreatment (CM) has been discussed as a factor that might have an impact on the occurrence and extent of biased attention in depression. The present study examined the association between CM and attention for facial emotions in currently depressed patients using eye-tracking methodology. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223956183132
Publisher Site
http://dx.doi.org/10.1016/j.jpsychires.2019.02.025DOI Listing
May 2019
3 Reads

Sleep complaints and cerebral white matter: A prospective bidirectional study.

J Psychiatr Res 2019 May 8;112:77-82. Epub 2019 Feb 8.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, USA. Electronic address:

Sleep complaints and brain changes co-occur in older adulthood, but the temporal relation between these processes is poorly understood. Poor sleep may destabilize axonal integrity and deteriorate white matter, but white matter pathology can also precede sleep complaints. Our objective was to explore a prospective, possibly bi-directional association between subjective sleep complaints and micro- and macro-structural properties of cerebral white matter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.002DOI Listing

Set-shifting in adolescents with weight-restored anorexia nervosa and their unaffected family members.

J Psychiatr Res 2019 May 28;112:71-76. Epub 2019 Feb 28.

Department of Psychiatry and Behavioral Sciences, Child and Adolescent Psychiatry, Stanford University School of Medicine, Stanford, CA. 401 Quarry Rd, Stanford, CA, 94305, USA.

Set-shifting difficulties have been suggested to underlie rigid and inflexible thinking in patients with anorexia nervosa (AN). Studies reported set-shifting deficiencies in adults with AN and also in their unaffected family members, suggesting that set-shifting deficits are heritable in AN. Surprisingly, studies failed to show set-shifting difficulties in adolescents with AN. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223956183142
Publisher Site
http://dx.doi.org/10.1016/j.jpsychires.2019.02.022DOI Listing
May 2019
4 Reads

Estimating patient-specific treatment advantages in the 'Treatment for Adolescents with Depression Study'.

J Psychiatr Res 2019 May 28;112:61-70. Epub 2019 Feb 28.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001, Zürich, Switzerland.

The 'Treatment for Adolescents with Depression Study' (TADS, ClinicalTrials.gov, identifier: NCT00006286) was a cornerstone, randomized controlled trial evaluating the effectiveness of standard treatment options for major depression in adolescents. Whereas previous TADS analyses examined primarily effect modifications of treatment-placebo differences by various patient characteristics, less is known about the modification of inter-treatment differences, and hence, patient characteristics that might guide treatment selection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.021DOI Listing
May 2019
1 Read

Letter to the editor: When does selection generate bias in clinical samples?

J Psychiatr Res 2019 Feb 21. Epub 2019 Feb 21.

Medical School Hamburg, Department of Psychology, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.010DOI Listing
February 2019

Sleep-EEG in patients with primary aldosteronism in comparison to healthy controls and patients with depression.

J Psychiatr Res 2019 May 23;112:52-60. Epub 2019 Feb 23.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU, München, Germany. Electronic address:

The mineralocorticoid receptor (MR)/glucocorticoid receptor balance plays an important role in the pathophysiology of anxiety and depression. Aldosterone, a primary MR ligand, seems to be related to the pathophysiology of anxiety and depressive symptoms. The objective of this study was to investigate effects of aldosterone excess on sleep EEG, as sleep EEG is a tool to gain insight into psychoneuroendocrine function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.020DOI Listing

Letter to the editor: Methodological comments to "Electroacupuncture for tapering off long-term benzodiazepine use: A randomized controlled trial".

J Psychiatr Res 2019 Feb 21. Epub 2019 Feb 21.

Laboratory Center of Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.012DOI Listing
February 2019
3.957 Impact Factor

Endogenous oxytocin levels are associated with impaired social cognition and neurocognition in schizophrenia.

J Psychiatr Res 2019 May 25;112:38-43. Epub 2019 Feb 25.

University of Maryland School of Medicine, Department of Psychiatry and Maryland Psychiatric Research Center, USA.

Intranasal administration of the neuropeptide oxytocin (OT) has yielded inconsistent effects on social cognition and general cognition in individuals with schizophrenia (SZ). Few studies have examined whether endogenous peripheral OT levels are also associated with social and general cognition in SZ. The current study examined whether plasma OT levels are associated with performance on a higher-order social cognition measure (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.017DOI Listing
May 2019
1 Read

Behavioral and neural correlates of memory suppression in PTSD.

J Psychiatr Res 2019 May 26;112:30-37. Epub 2019 Feb 26.

National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA; Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA.

Previous work has shown that healthy individuals can actively suppress emotional memories through recruitment of the lateral prefrontal cortex. By contrast, individuals with posttraumatic stress disorder (PTSD) frequently experience unwanted memories of their traumatic experiences, even when making explicit efforts to avoid them. However, little is known regarding the behavioral and neural effects of memory suppression among individuals with PTSD. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223956183132
Publisher Site
http://dx.doi.org/10.1016/j.jpsychires.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440538PMC
May 2019
3 Reads

Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients.

J Psychiatr Res 2019 May 22;112:23-29. Epub 2019 Feb 22.

Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta. FLENI, Buenos Aires, Argentina; National Council for Scientific and Technological Research (CONICET), Argentina; Servicio de Psiquiatría. FLENI, Buenos Aires, Argentina; Departamento de Psiquiatría y Salud Mental, Unidad docente FLENI, Universidad de Buenos Aires, Facultad de Medicina, Argentina. Electronic address:

Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions subserving executive functions in asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD), suggesting that premature episodic memory deficits could be associated to executive dysfunction in this model. We hypothesized that O-LOAD would exhibit reduced executive performance evidenced by increased errors and decreased strategy use on an episodic memory task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.016DOI Listing
May 2019
1 Read

Differences in multihormonal responses to the dopamine agonist apomorphine between unipolar and bipolar depressed patients.

J Psychiatr Res 2019 May 19;112:18-22. Epub 2019 Feb 19.

Department of Mental Health, Parc Taulí University Hospital, Sabadell, Barcelona, Spain; Institut d'Investigació i Innovació Parc Taulí (I3PT), Sabadell, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès, Barcelona, Spain.

Background: A large number of studies suggest that dopaminergic function may be impaired in depressed patients, particularly in bipolar patients. The dopamine D2/D1 agonist apomorphine (APO) can be useful in the evaluation of dopaminergic function. However, most studies show conflicting results in APO test responses when evaluating unipolar and bipolar depressed patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.009DOI Listing
May 2019
2 Reads

The left dorsolateral prefrontal cortex volume is reduced in adults reporting childhood trauma independent of depression diagnosis.

J Psychiatr Res 2019 May 25;112:12-17. Epub 2019 Feb 25.

Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address:

Both major depressive disorder (MDD) and childhood trauma have been linked with brain structural changes. As childhood trauma is more highly prevalent in MDD patients, previous morphometric findings in MDD therefore might have been confounded by childhood trauma. This study aimed to differentiate the impact of childhood trauma from the influence of MDD diagnosis on gray matter volume (GMV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.014DOI Listing
May 2019
3.957 Impact Factor

Reply to Wang and Chen.

J Psychiatr Res 2019 Feb 22. Epub 2019 Feb 22.

School of Nursing, The Hong Kong Polytechnic University, The Hong Kong SAR, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2019.02.013DOI Listing
February 2019
3 Reads