4,354 results match your criteria Journal of psychiatric research[Journal]


Cannabis use behaviors and prevalence of anxiety and depressive symptoms in a cohort of Canadian medicinal cannabis users.

J Psychiatr Res 2019 Jan 31;111:134-139. Epub 2019 Jan 31.

MacAnxiety Research Centre, McMaster University, L02-1057 Main St W, Hamilton, ON, L8S 1B7, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada; Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada. Electronic address:

Cannabis is commonly used recreationally for its euphoric and relaxing effects, while its medical use is permitted in several jurisdictions. With only low-quality evidence suggesting anxiolytic effects of cannabis and strong public sentiment surrounding such purported effects, the purpose of this study was to examine the prevalence of cannabis for medicinal purposes (CMP) use for anxiety symptoms. An online survey was disseminated to CMP users registered with a Canadian licensed producer. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.024DOI Listing
January 2019
1 Read

Seasonality of antidepressant prescriptions and sick leaves.

J Psychiatr Res 2019 Jan 26;111:128-133. Epub 2019 Jan 26.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

The aim of the present study was to estimate the number of patients with a seasonal prescription pattern of antidepressants, which might be taken as a surrogate marker for medicated patients with seasonal affective disorder (SAD). Furthermore, we examined the time course of sick leaves for patients with seasonal and non-seasonal prescriptions of antidepressants. A retrospective analysis of prescription data of all patients insured by the Sickness Fund Burgenland (BGKK) between 2005 and 2016 was performed. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.020DOI Listing
January 2019

An examination of the relationship between hoarding symptoms and hostility.

J Psychiatr Res 2019 Jan 31;111:121-127. Epub 2019 Jan 31.

Department of Psychology, Florida State University, USA. Electronic address:

Hoarding disorder (HD) is a persistent and severe psychiatric condition in which individuals are unable to discard possessions, which results in considerable clutter. Individuals who hoard often endorse interpersonal difficulties and social isolation. However, little research has examined mechanisms that may help to explain this relationship. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.025DOI Listing
January 2019

Brain-enriched MicroRNA-184 is downregulated in older adults with major depressive disorder: A translational study.

J Psychiatr Res 2019 Jan 23;111:110-120. Epub 2019 Jan 23.

Graduate Program in Molecular Medicine, Federal University of Minas Gerais School of Medicine, Belo Horizonte, MG, Brazil; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Geriatric Psychiatry Division, Center for Addiction and Mental Health, Toronto, ON, Canada. Electronic address:

Changes in microRNAs (miRNAs) expression have been described in major depressive disorder in young and middle-aged adults. However, no study has evaluated miRNA expression in older adults with major depression (or late-life depression [LLD]). Our primary aim was to evaluate the expression of miRNAs in subjects with LLD. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.019DOI Listing
January 2019
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Mortality in hospital patients with and without mental disorders: A data-linkage cohort study.

J Psychiatr Res 2019 Jan 21;111:104-109. Epub 2019 Jan 21.

Rural Clinical School, Faculty of Medicine, The University of Queensland, Toowoomba, Queensland, Australia; School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

Objective: In the general population, people with mental disorders have increased mortality. This association, however, has not been explored in a population who at some time were inpatients of a public hospital.

Methods: The sampling frame was patients admitted to an Australian regional public hospital 1996-2010. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.015DOI Listing
January 2019
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Maternal inflammation during pregnancy and offspring psychiatric symptoms in childhood: Timing and sex matter.

J Psychiatr Res 2019 Jan 10;111:96-103. Epub 2019 Jan 10.

Department of Psychology, Temple University, Philadelphia, PA, USA. Electronic address:

Objective: Maternal infection during pregnancy has been associated with increased risk of offspring psychopathology, including depression. As most infections do not cross the placenta, maternal immune responses to infection have been considered as potentially contributing to this relationship. This study examined whether gestational timing of maternal inflammation during pregnancy is associated with offspring internalizing and/or externalizing symptoms during childhood and, further, whether fetal sex moderated this relationship. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.009DOI Listing
January 2019

Debt stress, psychological distress and overall health among adults in Ontario.

J Psychiatr Res 2019 Jan 9;111:89-95. Epub 2019 Jan 9.

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

The objective of this study was to examine debt stress and its association with psychological distress and overall health. Data were derived from the 2014-2016 annual cycles of a cross-sectional telephone survey of the general population of adults 18 years of age and older within the province of Ontario, Canada. The present analyses focused on a pooled sample of 8045 adults. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183047
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http://dx.doi.org/10.1016/j.jpsychires.2019.01.008DOI Listing
January 2019
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Telomere shortening in blood leukocytes of patients with posttraumatic stress disorder.

J Psychiatr Res 2019 Jan 21;111:83-88. Epub 2019 Jan 21.

Laboratory of Human Genomics and Immunomics, Institute of Molecular Biology National Academy of Sciences RA, Yerevan, Armenia; Institute of Biomedicine and Pharmacy, Russian-Armenian University, Yerevan, Armenia.

Telomeres are protective fragments on chromosome ends involved in maintaining genome stability, preventing chromosomal fusions, regulation of cell division. It was shown that telomere attrition rate is accelerated in age-related diseases, as well as in response to physiological and psychosocial stress. The aim of this study was to evaluate relative leukocyte telomere length (LTL) in patients with post traumatic stress disorder (PTSD), as well as to investigate association of functional SNPs of telomerase TERC and TERT genes with LTL and PTSD. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.018DOI Listing
January 2019
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Exploration of microbiota targets for major depressive disorder and mood related traits.

J Psychiatr Res 2019 Jan 19;111:74-82. Epub 2019 Jan 19.

Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address:

Growing evidence suggests the link between gut microbiota and mood regulation. The current study aimed to identify microbiota targets for major depressive disorder (MDD) and mood-related traits in Taiwanese samples, while taking into account the influence of dietary patterns. We recruited 36 MDD patients and 37 healthy controls for 16S rRNA gene sequencing. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.016DOI Listing
January 2019
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Comparability of blinded remote and site-based assessments of response to adjunctive esketamine or placebo nasal spray in patients with treatment resistant depression.

J Psychiatr Res 2019 Jan 19;111:68-73. Epub 2019 Jan 19.

Janssen Research & Development LLC (Titusville NJ, Spring House PA, and San Diego CA), USA.

Functional unblinding due to treatment emergent adverse events (TEAEs) may occur with any investigational drug and poses a challenge for double-blind, placebo-controlled studies. This pilot study compared site-based Montgomery-Asberg Depression Rating Scale (MADRS) scores to remote, site-independent scores by blinded raters. Audio-digital recordings of site-based MADRS interviews were obtained from a subset of patients during a double-blind, placebo-controlled study of esketamine nasal spray or placebo spray in treatment resistant depression (Clinical Trials Registration: NCT01998958). Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.017DOI Listing
January 2019
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Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study.

J Psychiatr Res 2019 Jan 4;111:59-67. Epub 2019 Jan 4.

Assurex Health, Inc., 6960 Cintas Blvd, Mason, OH, 45040, USA; Myriad Genetics, Inc., 320 Wakara Way, Salt Lake City, UT, 84108, USA.

Current prescribing practices for major depressive disorder (MDD) produce limited treatment success. Although pharmacogenomics may improve outcomes by identifying genetically inappropriate medications, studies to date were limited in scope. Outpatients (N = 1167) diagnosed with MDD and with a patient- or clinician-reported inadequate response to at least one antidepressant were enrolled in the Genomics Used to Improve DEpression Decisions (GUIDED) trial - a rater- and patient-blind randomized controlled trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183100
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http://dx.doi.org/10.1016/j.jpsychires.2019.01.003DOI Listing
January 2019
9 Reads

Comparative efficacy and tolerability of antipsychotics as augmentations in adults with treatment-resistant obsessive-compulsive disorder: A network meta-analysis.

J Psychiatr Res 2019 Jan 14;111:51-58. Epub 2019 Jan 14.

Mental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing, China; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

We performed a network meta-analysis to build clear hierarchies of efficacy and tolerability of antipsychotics to augment serotonin reuptake inhibitors (SRIs) for treatment-resistant obsessive-compulsive disorder (OCD) in adults. PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched on September 8, 2018. Randomized controlled trials investigating antipsychotics as augmentation agents were included. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.014DOI Listing
January 2019
2 Reads

The cortisol awakening response at admission to hospital predicts depression severity after discharge in MDD patients.

J Psychiatr Res 2019 Jan 7;111:44-50. Epub 2019 Jan 7.

Faculty for Health and Welfare Sciences, Østfold University College, Norway; CHBD Research Group, Division of Clinical Neuroscience, Oslo University Hospital, Norway.

Major Depressive Disorder (MDD) is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and altered cortisol awakening response (CAR), a non-invasive biomarker for HPA axis reactivity. We theorized that the CAR resembles the accumulated effects of depression over time, and may therefore predict depressive symptom severity once patients return home following inpatient treatment. Two studies are reported. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.002DOI Listing
January 2019
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Gender inequality and depression among medical students: A global meta-regression analysis.

J Psychiatr Res 2019 Jan 11;111:36-43. Epub 2019 Jan 11.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Depression is a serious mental health problem with a high prevalence among medical students. It is unclear whether a gender disparity of depression exists in this population, and whether gender inequality influences depression estimates by gender. We conducted a systematic search for published systematic reviews or meta-analyses in six databases and primary studies were obtained from those records. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.013DOI Listing
January 2019
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Late-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011-2014.

J Psychiatr Res 2019 Jan 11;111:30-35. Epub 2019 Jan 11.

Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.

Discrepancies exist on the associations of late-life depression with cognition, and synergistic effect of depression and diabetes on cognition among older adults was suggested in literature. We aimed to examine the associations of late-life depression with cognitive function in a representative sample of older adults in the U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183090
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http://dx.doi.org/10.1016/j.jpsychires.2019.01.012DOI Listing
January 2019
4 Reads

Increased levels of serum leptin in the early stages of psychosis.

J Psychiatr Res 2019 Jan 11;111:24-29. Epub 2019 Jan 11.

Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Reus, Spain; Centro de Investigación Biomédica en Red en Salud Mental, CIBERSAM, Spain.

Background: Studies evaluating leptin levels in patients with first-episode psychoses (FEP) have been inconclusive, and apparently, the high levels of leptin reported in patients with schizophrenia may be associated with weight gain. The aim of this study was to evaluate leptin levels at the early stages of the disease and the relationship between leptin and lifestyle habits, stress-related variables and metabolic parameters.

Methods: In total, 14 at-risk mental state (ARMS) patients, 39 FEP patients, 32 psychotic patients in the critical period (CP) and 21 healthy controls (HCs) were assessed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183115
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http://dx.doi.org/10.1016/j.jpsychires.2019.01.006DOI Listing
January 2019
5 Reads

Child abuse interacts with hippocampal and corpus callosum volume on psychophysiological response to startling auditory stimuli in a sample of veterans.

J Psychiatr Res 2019 Jan 11;111:16-23. Epub 2019 Jan 11.

San Francisco VA Health Care System, 4150 Clement St. (116P), San Francisco, CA, 94121, USA; Northern California Institute for Research and Education (NCIRE), The Veterans Health Research Institute, San Francisco, CA, 94121, USA; Department of Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94143, USA. Electronic address:

Child abuse (CA), which is linked to posttraumatic stress disorder (PTSD), has been associated with a reduction in both hippocampal and corpus callosum (CC) volume. However, few studies have explored these relationships on psychophysiological variables related to trauma exposure. Therefore, we assessed whether the interaction between CA and hippocampal and CC volume were associated with enhanced fear potentiated psychophysiological response patterns in a sample of Veterans. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.011DOI Listing
January 2019
2 Reads

A schizophrenia associated CMYA5 allele displays differential binding with desmin.

J Psychiatr Res 2019 Jan 10;111:8-15. Epub 2019 Jan 10.

Department of Human and Molecular Genetics, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA, 23298-0033, USA. Electronic address:

CMYA5 is a candidate gene for schizophrenia because of the genetic association of variant rs10043986 (C > T) to this severe mental disorder. Studies of CMYA5 and its gene product, myospryn, in the brain and neuronal cells have not been previously reported. The SNP rs10043986 changes the 4,063rd amino acid from Pro to Leu, which is likely to alter protein function. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.007DOI Listing
January 2019

The role of illness engulfment in the association between insight and depressive symptomatology in schizophrenia.

J Psychiatr Res 2019 Jan 11;111:1-7. Epub 2019 Jan 11.

Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Montreal, QC, H4H 1R3, Montreal, Canada; Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada. Electronic address:

Good clinical insight in schizophrenia tends to be associated with better outcomes, but also with increased depression. We hypothesized that illness engulfment, a process whereby an individual's self-concept becomes defined solely by illness and the 'patient identity' becomes primary, is a mediating and/or moderating factor in the association between insight and depressive symptomatology in schizophrenia. Mediation and moderation analyses were conducted using the PROCESS macro on data from 140 individuals with enduring schizophrenia who completed measures of the insight dimension of 'Awareness of Illness and Need for Treatment' (AINT), the Calgary Depression Scale, and the Modified Engulfment Scale. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.11.001DOI Listing
January 2019
7 Reads

More optimal but less regulated dorsal and ventral visual networks in patients with major depressive disorder.

J Psychiatr Res 2019 Mar 9;110:172-178. Epub 2019 Jan 9.

Medical Imaging Department, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Previous studies indicate that major depressive disorder (MDD) can profoundly modify the visual cortices as well as the visuo-attentional systems of brain. However, little is known on the specific pattern of the whole-network-level abnormalities. In this study, resting-state functional magnetic resonance imaging data were collected from 159 participants, including 86 medication-free MDD patients and 73 matched healthy controls. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.005DOI Listing

Sex differences in response to ketamine as a rapidly acting intervention for treatment resistant depression.

J Psychiatr Res 2019 Mar 8;110:166-171. Epub 2019 Jan 8.

Massachusetts General Hospital, USA.

Background: While ketamine has been increasingly studied for treatment resistant depression (TRD), the impact of sex differences on treatment outcomes has not been well studied. The objective was to ascertain whether there were differences in response to a single administration of ketamine for TRD between men and women, and between pre- and post-menopausal women.

Methods: A randomized, double-blind, placebo-controlled trial (N = 99; N = 50 male; N = 49 female) was conducted to investigate the efficacy of intravenous ketamine versus active placebo as augmentation of antidepressant therapy for TRD. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360121PMC

Hypertensive disorders of pregnancy and the risk of anxiety disorders in adolescence: Findings from the Avon Longitudinal Study of Parents and Children.

J Psychiatr Res 2019 Mar 3;110:159-165. Epub 2019 Jan 3.

Institute for Social Science Research, The University of Queensland, Brisbane, Australia; School of Public Health, Curtin University, Western Australia, Australia.

Background: The effect of hypertensive disorders of pregnancy (HDP) on offspring anxiety disorders in adolescence is not yet known. This study aims to examine the association between HDP and offspring anxiety disorders at age 15 years.

Methods: We used data from 5231 mother-offspring pairs from the United Kingdom based Avon Longitudinal Study of Parents and Children (ALSPAC). Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.001DOI Listing
March 2019
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Childhood adversities, negative life events and outcomes of non-pharmacological treatments for depression in primary care: A secondary analysis of a randomized controlled trial.

J Psychiatr Res 2019 Mar 4;110:152-158. Epub 2019 Jan 4.

Unit of Epidemiology and Public Health Intervention Research (EPHIR), Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Non-pharmacological treatments for depression are effective and available in primary care, but useful prognostic factors are lacking. Childhood adversities (CA) and negative recent life events (RLE) increase the risk and severity of depression, though their effect on treatment outcomes remains understudied. Using a sample of 737 adult participants of a multicenter randomized controlled trial receiving physical exercise, internet based cognitive-behavioral therapy or treatment as usual, alone or in combination with antidepressants, this prospective study aimed to determine the impact of CA, RLE and their interaction as predictors of outcomes of non-pharmacological treatments for mild-moderate depression in primary care. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.004DOI Listing

Are subjective memory complaints indicative of objective cognitive decline or depressive symptoms? Findings from the English Longitudinal Study of Ageing.

J Psychiatr Res 2019 Mar 6;110:143-151. Epub 2018 Dec 6.

University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK. Electronic address:

Older adults often complain about their memory ability, but it is not clear to what extent subjective memory complaints accurately reflect objective cognitive dysfunctions. The concordance between objective and subjective cognitive performance may be affected by depressive symptoms and by declining insight into cognitive deficits. This study aims to examine longitudinal associations between subjective memory complaints, objective cognitive performance and depressive symptoms. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.005DOI Listing
March 2019
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Does attrition affect estimates of association: A longitudinal study.

J Psychiatr Res 2019 Mar 24;110:127-142. Epub 2018 Dec 24.

School of Public Health, The University of Queensland, Herston 4006, Australia.

Survey research frequently involves missing cases attributable to refusals to participate, lack of success in accessing all potential respondents or loss to follow-up in longitudinal studies. There is concern that those not recruited or those lost are a select group whose absence from a study may bias the findings of the study. This study provides a test of the extent to which selective loss to follow-up in a longitudinal study may lead to biased findings. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.022DOI Listing

A meta-analysis of transcranial direct current stimulation for schizophrenia: "Is more better?"

J Psychiatr Res 2019 Mar 10;110:117-126. Epub 2018 Dec 10.

Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Geriatric Mental Health Division, CAMH, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, CAMH, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Transcranial direct current stimulation (tDCS) has generated interest in recent years as a potential adjunctive treatment for patients with schizophrenia. The primary objective of this meta-analysis was to evaluate the efficacy of tDCS on positive symptoms, particularly auditory hallucinations, and negative symptoms. A literature search of randomized sham-controlled trials was conducted using the OVID database on October 9, 2018. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.009DOI Listing
March 2019
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Changes in the association between postpartum depression and mother-infant bonding by parity: Longitudinal results from the Japan Environment and Children's Study.

J Psychiatr Res 2019 Mar 28;110:110-116. Epub 2018 Nov 28.

Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan; Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. Electronic address:

The results of several epidemiological studies have shown a moderate association between postpartum depression (PPD) and mother-infant bonding (MIB); however, associations and changes that longitudinally considered parity were not reported. We investigated the possible association between PPD and MIB at one month after birth, in addition, the changes of these indices by parity. From a dataset comprising 103,099 maternal registrations in The Japan Environment and Children's Study, the present study analyzed complete data on questionnaires for 76,363 women who participated once (cross-sectional group) and 3753 women who participated twice (follow-up subgroup). Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.11.022DOI Listing
March 2019
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Brain-derived neurotrophic factor is a biomarker for subjective insomnia but not objectively assessable poor sleep continuity.

J Psychiatr Res 2019 Mar 4;110:103-109. Epub 2019 Jan 4.

University of Basel, Psychiatric Clinics (UPK), Basel, Switzerland; Psychiatric Hospital Sonnenhalde, Riehen, Switzerland.

Objectives: Brain-derived neurotrophic factor (BDNF) is a central mediator of the effects of stress on neuronal plasticity. Patients with subjective insomnia have significantly lower serum BDNF (sBDNF) levels. The aims of the present study were to investigate the associations of sBDNF with, 1) subjective and 2) objective sleep; 3) to investigate the associations between dimensions of psychopathology, subjective sleep and sBDNF, and 4) to investigate the associations between insomnia, sBDNF and cortisol. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.020DOI Listing
March 2019
2 Reads

Development of a mobile application (App) to delineate "digital chronotype" and the effects of delayed chronotype by bedtime smartphone use.

J Psychiatr Res 2019 Mar 8;110:9-15. Epub 2018 Dec 8.

Department and Graduate School of Electrical Engineering, Tamkang University, New Taipei City, Taiwan. Electronic address:

The widespread use and deep reach of smartphones motivate the use of mobile applications to continuously monitor the relationship between circadian system, individual sleep patterns, and environmental effects. We selected 61 adults with 14-day data from the "Know Addiction" database. We developed an algorithm to identify the "sleep time" based on the smartphone behaviors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183090
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http://dx.doi.org/10.1016/j.jpsychires.2018.12.012DOI Listing
March 2019
3 Reads

Psychotic symptoms in youth with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) may reflect syndrome severity and heterogeneity.

J Psychiatr Res 2019 Mar 14;110:93-102. Epub 2018 Nov 14.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States; Stanford Pediatric Acute-onset Neuropsychiatric Sydrome Clinic and Research Program at Lucile Packard Children's Hospital, Stanford University, Stanford, CA, United States.

Objective: In the clinical syndrome Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), obsessive compulsive disorder (OCD) and/or food refusal symptoms have an abrupt-onset (over 48 h) coupled with at least two other specified neuropsychiatric symptoms. We aimed to characterize in detail for the first time, psychotic symptoms experienced by children with PANS as well as the impact of psychotic symptoms on disease severity and course of illness. We inform about the diagnosis of the clinical description: PANS and hope to improve evaluation, treatment, diagnostic validity and future investigation. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.11.013DOI Listing
March 2019
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Implications of de novo mutations in guiding drug discovery: A study of four neuropsychiatric disorders.

J Psychiatr Res 2019 Mar 14;110:83-92. Epub 2018 Dec 14.

School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Recent studies have suggested an important role of de novo mutations (DNMs) in neuropsychiatric disorders. As DNMs are not subject to elimination due to evolutionary pressure, they are likely to have greater disruptions on biological functions. While a number of sequencing studies have been performed on neuropsychiatric disorders, the implications of DNMs for drug discovery remain to be explored. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183087
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http://dx.doi.org/10.1016/j.jpsychires.2018.12.015DOI Listing
March 2019
2 Reads

Discoidin domain receptor 1 gene variants are associated with decreased white matter fractional anisotropy and decreased processing speed in schizophrenia.

J Psychiatr Res 2019 Mar 24;110:74-82. Epub 2018 Dec 24.

Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Reus, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Electronic address:

DDR1 has been linked to schizophrenia (SZ) and myelination. Here, we tested whether DDR1 variants in people at risk for SZ influence white matter (WM) structural variations and cognitive processing speed (PS). First, following a case-control design (Study 1), SZ patients (N = 1193) and controls (N = 1839) were genotyped for rs1264323 and rs2267641 at DDR1, and the frequencies were compared. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183103
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http://dx.doi.org/10.1016/j.jpsychires.2018.12.021DOI Listing
March 2019
1 Read

The effectiveness of omega-3 supplementation in reducing ADHD associated symptoms in children as measured by the Conners' rating scales: A systematic review of randomized controlled trials.

J Psychiatr Res 2019 Mar 12;110:64-73. Epub 2018 Dec 12.

University of Manchester, Faculty of Biology, Medicine and Health, United Kingdom, England.

Omega-3 supplements are considered to have anti-inflammatory effects which may be beneficial as inflammation has been linked to ADHD. The aim of this review is to examine the effectiveness of omega-3 supplementation at reducing ADHD symptoms in children and adolescents. Medline, Cinahl+, PsycINFO, Cochrane and Embase were searched for trials investigating the effects of omega-3 supplementation in children and adolescents with ADHD. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.002DOI Listing
March 2019
2 Reads

Ambient temperature and solar insolation are associated with decreased prevalence of SSRI-treated psychiatric disorders.

J Psychiatr Res 2019 Mar 19;110:57-63. Epub 2018 Dec 19.

University of Washington, Retired Associate Professor on the Axillary Faculty, USA.

Serotonergic function is known to fluctuate in association with light and temperature. Serotonin-related behaviors and disorders similarly vary with climatic exposure, but the associations are complex. This complexity may reflect the importance of dose and timing of exposure, as well as acclimation. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.017DOI Listing

Brain network functional connectivity and cognitive performance in major depressive disorder.

J Psychiatr Res 2019 Mar 22;110:51-56. Epub 2018 Nov 22.

The Center for Cognitive Medicine, Department of Psychiatry, Vanderbilt University Medical Center, United States; GRECC, VA, Tennessee Valley Healthcare System, United States.

Background: Major depressive disorder (MDD) is one of the most prevalent and debilitating psychiatric disorders. Cognitive complaints are commonly reported in MDD and cognitive impairment is a criterion item for MDD diagnosis. As cognitive processes are increasingly understood as the consequences of distributed interactions between brain regions, a network-based approach may provide novel information about the neurobiological basis of cognitive deficits in MDD. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360105PMC
March 2019
2 Reads

Latent toxoplasmosis and psychiatric symptoms - A role of tryptophan metabolism?

J Psychiatr Res 2019 Mar 17;110:45-50. Epub 2018 Dec 17.

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, Denmark.

Toxoplasma gondii (TOX) is a common parasite which infects approximately one third of the human population. In recent years, it has been suggested that latent toxoplasmosis may be a risk factor for the development of mental disorders, particularly schizophrenia and anxiety. With regards to depression the results have been varied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183116
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http://dx.doi.org/10.1016/j.jpsychires.2018.12.016DOI Listing
March 2019
7 Reads

Plasma microRNA expression levels and their targeted pathways in patients with major depressive disorder who are responsive to duloxetine treatment.

J Psychiatr Res 2019 Mar 8;110:38-44. Epub 2018 Dec 8.

Department of Pathology and Molecular Medicine, Queen's University, RM 401, Richardson Lab, 88 Stuart St., Kingston, Ontario, K7L 3N6, Canada. Electronic address:

Major depressive disorder (MDD) is a complex disorder with many pathways known to contribute to its pathogenesis, such as apoptotic signaling, with antidepressants having been shown to target these pathways. In this study, we explored microRNAs as predictive markers of drug response to duloxetine, a serotonin-norepinephrine reuptake inhibiter, using peripheral blood samples from 3 independent clinical trials (NCT00635219; NCT0059991; NCT01140906) comparing 6-8 weeks of treatment with duloxetine to placebo treatment in patients with MDD. Plasma microRNA was extracted and sequenced using the Ion Proton Sequencer. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.007DOI Listing

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.

J Psychiatr Res 2019 Mar 8;110:31-37. Epub 2018 Dec 8.

The Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The University of Melbourne, Richmond, VIC, Australia.

Partial or non-response to antidepressants in Generalized Anxiety Disorder (GAD) is common in clinical settings, and adjunctive biological interventions may be required. Adjunctive herbal and nutraceutical treatments are a novel and promising treatment option. L-theanine is a non-protein amino acid derived most-commonly from tea (Camellia sinensis) leaves, which may be beneficial in the treatment of anxiety and sleep disturbance as suggested by preliminary evidence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183099
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http://dx.doi.org/10.1016/j.jpsychires.2018.12.014DOI Listing
March 2019
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Trait-level facets of impulsivity and momentary, naturalistic eating behavior in children and adolescents with overweight/obesity.

J Psychiatr Res 2019 Mar 15;110:24-30. Epub 2018 Dec 15.

Department of Psychology, Illinois Institute of Technology, 3424 South State St., Chicago, IL, 60616, USA.

Impulsivity, and specific subdomains of inhibitory control and reward sensitivity, are trait-level factors that have been implicated in the onset and maintenance of pediatric obesity and disordered eating, but their associations with real-world eating behavior are unknown. We investigated associations of these trait-level constructs with naturalistic, momentary measures of loss of control (LOC) eating and overeating severity in a heterogeneous sample of youth (n = 40), aged 8-14y, with overweight/obesity. Self-report, parent-report, and behavioral data on trait-level impulsivity, reward sensitivity, and inhibitory control, respectively, were collected in the context of a 14-day ecological momentary assessment (EMA) protocol in which participants reported on their eating behavior, mood, hunger, and palatability of foods consumed in real-time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183092
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http://dx.doi.org/10.1016/j.jpsychires.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360116PMC
March 2019
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Age differences in DSM-IV borderline personality disorder symptom expression: Results from a national study using item response theory (IRT).

J Psychiatr Res 2019 Mar 15;110:16-23. Epub 2018 Dec 15.

Department of Psychiatry, Assistance Publique-Hôpitaux de Paris, Hôpital Corentin-Celton, Issy-les-Moulineaux, France; INSERM UMR 894, Psychiatry and Neurosciences Center, Paris, France; Paris Descartes University, Pôles de recherche et d'enseignement supérieur Sorbonne Paris Cité, Paris, France.

Limited literature suggests that there may be age-related differences in borderline personality disorder (BPD) symptom expression. The present study used item response theory (IRT) methods to examine whether there are age differences in the likelihood of endorsing DSM-IV symptoms of BPD, when equating for levels of BPD symptom severity. Data were drawn from a nationally representative survey of adults in the US (n = 34,653), the second wave of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183091
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http://dx.doi.org/10.1016/j.jpsychires.2018.12.019DOI Listing
March 2019
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Sub-threshold bipolar disorder in medication-free young subjects with major depression: Clinical characteristics and antidepressant treatment response.

J Psychiatr Res 2019 Mar 8;110:1-8. Epub 2018 Dec 8.

Center for Behavioral Health, Cleveland Clinic, USA. Electronic address:

Background: This study, for the first time, compared illness and antidepressant response characteristics of young subjects with major depression (MDD) at low (LRMDD) or high-risk (HRMDD) for developing bipolar disorder with characteristics of young bipolar (BPD) subjects and healthy controls (HC).

Methods: One hundred and six young (15-30 yr), medication-free subjects MDD subjects (HRMDD, N = 51; LRMDD, N = 55) were compared with 32 BPD (Type I: 14; Type II: 18) as well as 49 HC subjects. Baseline illness characteristics and frequency of comorbid conditions were examined using Analysis of Variance and Cochran-Armitage trend test. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.006DOI Listing
March 2019
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Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders.

J Psychiatr Res 2019 Feb 1;109:202-213. Epub 2018 Dec 1.

Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06510, USA; Department of Psychology, Yale University, New Haven, CT, 06510, USA; Child Study Center, Yale School of Medicine, New Haven, CT, 06510, USA.

Anhedonia is a transdiagnostic construct that can occur independent of other symptoms of depression; its role in neuropsychiatric disorders that are not primarily affective, such as obsessive compulsive disorder (OCD), hoarding disorder (HD), and post-traumatic stress disorder (PTSD) has received limited attention. This paper addresses this gap. First, the data revealed a positive contribution of anhedonia, beyond the effects of general depression, to symptom severity in OCD but not in HD or PTSD. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.11.029DOI Listing
February 2019
3 Reads

Response to letter.

J Psychiatr Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Epidemiology, University of Florida, Gainesville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.011DOI Listing
December 2018

Does the frequency of administration of long acting injectable antipsychotics impact psychiatric outcomes and adverse effects: A systematic review and meta-analysis.

J Psychiatr Res 2019 Feb 10;109:193-201. Epub 2018 Dec 10.

University of Queensland, School of Medicine, Brisbane, Australia; Metro South Addiction and Mental Health Service, Brisbane, Australia.

Dosing regimens for depot antipsychotics range from two-to twelve-weekly administration. There are limited meta-analytic data regarding the effect of different injection frequencies of the same depot antipsychotic at the equivalent dose on psychiatric outcomes and adverse effects. This study investigated differences in psychiatric outcomes and adverse effects between different frequencies of depot antipsychotics through a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.004DOI Listing
February 2019
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Profiling of miRNAs in serum of children with attention-deficit hyperactivity disorder shows significant alterations.

J Psychiatr Res 2019 Feb 8;109:185-192. Epub 2018 Dec 8.

Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; CEINGE-biotecnologie Avanzate, Naples, Italy. Electronic address:

Background: Attention-deficit/hyperactivity disorder (ADHD), a common psychiatric disorder, is identified by abnormal levels of impulsivity, inattention, and hyperactivity. MiRNAs play important roles in neural network development of the brain. Circulating miRNAs (cmiRNAs) are offered as promising noninvasive markers for psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.013DOI Listing
February 2019
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Issues with inclusion and interpretation; a cause for concern in mHealth reviews?

J Psychiatr Res 2018 Dec 8. Epub 2018 Dec 8.

Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.010DOI Listing
December 2018
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Associations between childhood maltreatment and risk of myocardial infarction in adulthood: Results from the National Epidemiologic Survey on alcohol and Related Conditions.

J Psychiatr Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objective: Although childhood maltreatment has been reported to be associated with the incidence of cardiovascular diseases, its association with specific major cardiovascular events remains unclear. This study aimed to examine the relationship between different types of childhood maltreatment (CM) and myocardial infarction (MI) occurrence in a nationally representative sample.

Methods: We used data from the National Epidemiologic Survey of Alcohol and Related Conditions, a nationally representative US sample of adults aged 20 years and older (N = 34, 653). Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.001DOI Listing
December 2018
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Interaction of hormonal and social environments in understanding body image concerns in adolescent girls.

J Psychiatr Res 2019 Feb 7;109:178-184. Epub 2018 Dec 7.

Department of Psychology, Michigan State University, 316 Physics Rd #262, East Lansing, MI, 48824, USA.

During adolescence, peer approval becomes increasingly important and may be perceived as contingent upon appearance in girls. Concurrently, girls experience hormonal changes, including an increase in progesterone. Progesterone has been implicated in affiliative behavior but inconsistently associated with body image concerns. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317862PMC
February 2019
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The association between the longitudinal course of common mental disorders and subsequent physical activity status in young adults: A 30-year birth cohort study.

J Psychiatr Res 2019 Feb 6;109:173-177. Epub 2018 Dec 6.

Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia; School of Public Health, The University of Queensland, Herston, Australia; Metro North Mental Health, Royal Brisbane and Women's Hospital, Herston, Australia.

Low physical activity is a major public health concern. There has been extensive research examining the role of physical activity as a potentially modifiable risk factor for the onset of mental illness. However, fewer studies have reported how mental disorders affect future physical activity. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2018.12.003DOI Listing
February 2019
2 Reads

Subtypes of aggression in intermittent explosive disorder.

J Psychiatr Res 2019 Feb 19;109:164-172. Epub 2018 Oct 19.

McLean Hospital, Harvard Medical School, United States.

Research in aggression has distinguished two major subtypes of aggressive behavior: hostile and instrumental. Previous research has examined these subtypes in healthy individuals and forensic samples but not in intermittent explosive disorder (IED), a disorder characterized by recurrent and severe aggressive behavior. We examined aggression subtypes in individuals with IED, healthy subjects, and psychiatric control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223956183078
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http://dx.doi.org/10.1016/j.jpsychires.2018.10.013DOI Listing
February 2019
3 Reads