373,229 results match your criteria Journal of pharmacy & bioallied sciences[Journal]


ICU readmission of patients with cancer: Incidence, risk factors and mortality.

J Crit Care 2019 Feb 7;51:84-87. Epub 2019 Feb 7.

Department of Medicine, Section of Pulmonary and Critical Care, King Hussein Cancer Center, Jordan. Electronic address:

Purpose: Few studies evaluated ICU readmission in cancer patients. This study aimed to describe the incidence and risk factors for ICU readmission in cancer patients and the association with mortality.

Materials And Methods: A retrospective cohort study at a comprehensive cancer center, which included cancer patients who were discharged after their initial ICU admission over a 5-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcrc.2019.02.008DOI Listing
February 2019

Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones.

Bioorg Chem 2019 Feb 1;86:445-451. Epub 2019 Feb 1.

Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

In this work six PBN-related indanonitrones 1-6 have been designed, synthesized, and their neuroprotection capacity tested in vitro, under OGD conditions, in SH-SY5Y human neuroblastoma cell cultures. As a result, we have identified indanonitrones 1, 3 and 4 (EC = 6.64 ± 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2019.01.071DOI Listing
February 2019

Application of integrative cloud point extraction and concentration for the analysis of polyphenols and alkaloids in mulberry leaves.

J Pharm Biomed Anal 2019 Feb 10;167:132-139. Epub 2019 Feb 10.

Northeast Forestry University, Hexing Road 26, 150040, Harbin, PR China. Electronic address:

A simple and efficient method based on cloud point extraction and concentration combined with high performance liquid chromatography was developed for the simultaneous separation and determination of five target compounds (deoxynojirimycin, chlorogenic acid, rutin, isoquercitrin and astragalin) in mulberry leaves samples. Firstly, to obtain a high extraction rate, the ultrasound assisted extraction was developed on acid modified Triton X-114 system. Under the optimal conditions, the total maximum extraction yields of five target compounds reached 20. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2019.02.002DOI Listing
February 2019

Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.

Eur J Med Chem 2019 Feb 7;167:187-199. Epub 2019 Feb 7.

School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China. Electronic address:

To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity for human normal heptical cell line (HHL-5, LO2), and prominently inhibited lipopolysaccharides (LPS) induced IL-6, TNF-α secretion to exert its anti-inflammatory effect. Combining the data of cytotoxicity, cytocompatibility and anti-inflammatory activity, 3-pyridyl and -CF substituted 67 may be the potential anti-hepatoma agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.02.020DOI Listing
February 2019

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Eur J Med Chem 2019 Feb 8;167:161-186. Epub 2019 Feb 8.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. Electronic address:

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able to simultaneously hit cholinesterases, cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX) enzymes. Among the synthesized compounds, triazoles 5b and 5d, and thiosemicarbazide hybrid 6e emerged as promising new hits, being able to effectively inhibit human butyrylcholinesterase (hBChE), COX-2 and 15-LOX enzymes with a higher inhibitory potency than the reference inhibitors tacrine (for hBChE inhibition), celecoxib (for COX-2 inhibition) and both NDGA and Zileuton (for 15-LOX inhibition). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.02.012DOI Listing
February 2019

Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6.

Eur J Med Chem 2019 Feb 4;167:146-152. Epub 2019 Feb 4.

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal. Electronic address:

Polyphenols like caffeic acid and its phenethyl ester have been associated with potent anti-aggregating activity. Accordingly, we screened a library of polyphenols and synthetic derivatives thereof for their capacity to inhibit tau-aggregation using a thioflavin T-based fluorescence method. Our results show that the nitrocatechol scaffold is required for a significant anti-aggregating activity, which is enhanced by introducing bulky substituents at the side chain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.02.006DOI Listing
February 2019

Stroke occurrence while on antiplatelet therapy may predict atrial fibrillation detected after stroke.

Atherosclerosis 2019 Jan 24;283:13-18. Epub 2019 Jan 24.

Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan; Department of Information Management and Institute of Healthcare Information Management, National Chung Cheng University, Chiayi County, Taiwan. Electronic address:

Background And Aims: Stroke occurrence while on antiplatelet therapy, i.e., a breakthrough stroke, is often conveniently attributed to antiplatelet resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.007DOI Listing
January 2019

Intravaginal treatment with Marantodes Pumilum (Kacip Fatimah) ameliorates vaginal atrophy in rats with post-menopausal condition.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Marantodes pumilum (MP) (Kacip Fatimah) is used to maintain the well-being of post-menopausal women. However, its role in ameliorating post menopause-related vaginal atrophy (VA) is unknown.

Aims: To investigate the ability of intravaginal MP gel treatment to ameliorate VA in sex-steroid deficient condition, mimicking post-menopause. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.027DOI Listing
February 2019

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethnopharmacological Relevance: Ribes alpestre Decne has been commonly used in the treatment of joint complaints.

Aim Of Study: The present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.

Material And Methods: Complete Freunds adjuvant induced arthritis in Sprague Dawley rats was used to assess antiarthritic activity of aqueous ethanol extract, butanol and aqueous fractions at 200mg/kg oral dose for 28 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.025DOI Listing
February 2019

Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy.

Mol Cell Neurosci 2019 Feb 13. Epub 2019 Feb 13.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; UCIBIO, Departamento Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Caparica, Portugal. Electronic address:

Parkinson's disease (PD) is a progressive neurological disorder, mainly characterized by the progressive loss of dopaminergic neurons in the Substantia nigra pars compacta (SNpc) and by the presence of intracellular inclusions, known as Lewy bodies. Despite SNpc being considered the primary affected region in PD, the neuropathological features are confined solely to the nigro-striatal axis. With disease progression other brain regions are also affected, namely the cerebral cortex, although the spreading of the neurologic damage to this region is still not completely unraveled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mcn.2019.01.003DOI Listing
February 2019

Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats.

Reprod Toxicol 2019 Feb 13. Epub 2019 Feb 13.

Department of pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China. Electronic address:

Hepatic and pulmonary toxicity in fetal rats induced by pyrrolizidine alkaloids (PAs) was investigated. Retrorsine (RTS) or monocrotaline (MCT) was intragastrically administered during pregnancy. The reduction of body and tail lengths was consistent with body weight loss in PA-exposed fetuses, and pathological lesions in liver and lung were observed only in fetuses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reprotox.2019.02.006DOI Listing
February 2019

Cromolyn-crosslinked chitosan nanoparticles for the treatment of allergic rhinitis.

Eur J Pharm Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacy and Biotechnology, Via San Donato 19/2, University of Bologna, 40127 Bologna, Italy. Electronic address:

The aim of this work was to prepare new mucoadhesive nasal decongestant nanoparticles obtained by direct crosslinking between the cationic polymer chitosan and the anionic drug cromolyn. Different chitosan/cromolyn molar ratios were used in order to obtain nanoparticles of suitable size, encapsulation efficiency/drug loading and mucoadhesion. Moreover, the ability of the nanoparticles to deliver cromolyn into and through the nasal mucosa was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejps.2019.02.015DOI Listing
February 2019

Entry of therapeutics into the brain: influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.

Int J Pharm 2019 Feb 13. Epub 2019 Feb 13.

Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, United States. Electronic address:

The present work proposes a novel application of EPSA (not an acronym but found to be referred to by many as Exposed Polar Surface Area), a supercritical fluid chromatography (SFC) polarity readout for assisting in the prediction of the extent of drug permeation through the blood-brain barrier (BBB). For this purpose, EPSA values for 69 structurally unrelated acidic, basic, neutral and amphoteric compounds were determined by a validated SFC method. Additionally, water-accessible surface area (WASA) values for the whole dataset were calculated in silico and compared to experimentally determined EPSA values. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.02.008DOI Listing
February 2019

Self-association of cyclodextrins and cyclodextrin complexes in aqueous solutions.

Int J Pharm 2019 Feb 13. Epub 2019 Feb 13.

Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107, Reykjavík, Iceland. Electronic address:

Cyclodextrins (CDs) are oligosaccharides that self-assemble in aqueous solutions to form transient clusters, nanoparticles and small microparticles. The critical aggregation concentration (cac) of the natural αCD, βCD and γCD in pure aqueous solutions was estimated to be 25, 8 and 9 mg/ml, respectively. The cac of 2-hydroxypropyl-β-cyclodextrin (HPβCD), that consists of mixture of isomers, was estimated to be significantly higher or 118 mg/ml. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.02.004DOI Listing
February 2019

Absolute configuration determination of asarinin by synchrotron radiation with crystalline sponge method.

Fitoterapia 2019 Feb 13. Epub 2019 Feb 13.

Key Laboratory on Protein Chemistry and Structural Biology, China Pharmaceutical University, Nanjing 210009, PR China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, PR China. Electronic address:

The determination of the absolute configuration of natural products still faces many challenges, especially the active pharmaceutical ingredient which is trace, oily and novel structures. Currently, NMR requires chiral reagents in determining the absolute configuration; ECD involves theoretical calculations and requires chromophores. In this study, the absolute configuration of asarinin had successfully identified by using synchrotron radiation with crystalline sponge method and combining MS with NMR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.02.010DOI Listing
February 2019

Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacy, Uppsala Biomedical Center, Uppsala University, 751 23 Uppsala, Sweden; Swedish Drug Delivery Forum (SDDF), Uppsala University, Sweden. Electronic address:

In this review we will discuss how computational methods, and in particular classical molecular dynamics simulations, can be used to calculate solubility of pharmaceutically relevant molecules and systems. To the extent possible, we focus on the non-technical details of these calculations, and try to show also the added value of a more thorough and detailed understanding of the solubilization process obtained by using computational simulations. Although the main focus is on classical molecular dynamics simulations, we also provide the reader with some insights into other computational techniques, such as the COSMO-method, and also discuss Flory-Huggins theory and solubility parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpb.2019.02.007DOI Listing
February 2019

Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish.

Toxicol Lett 2019 Feb 13. Epub 2019 Feb 13.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China. Electronic address:

The aim of this study was to investigate the hepatotoxic effect and its underlying mechanism of aloe emodin (AE). AE was docked with the targets of NF-κB inflammatory pathway and P53 apoptosis pathway respectively by using molecular docking technique. To verify the results of molecular docking and further investigate the hepatotoxicity mechanism of AE, the zebrafish Tg (fabp10: EGFP) was used as an animal model in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2019.02.007DOI Listing
February 2019

UVB drives different stages of epigenome alterations during progression of skin cancer.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. Electronic address:

Exposure to ultraviolet B (UVB) irradiation results in multitude of cellular responses including generation of reactive oxygen species and DNA damage and is responsible for non-melanoma skin cancers (NMSCs). Although genetic mutation is well documented, the epi-mutation, the alteration in epigenetics, remains elusive. In this study, we utilized CpG Methyl-seq to identify a genome-wide DNA CpG methylation, to profile the DNA methylation in UVB-irradiated SKH-1 mouse skin epidermis and non-melanoma skin papillomas at various stages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2019.02.010DOI Listing
February 2019

Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through FGF13-AS1/IGF2BPs/Myc feedback loop.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China. Electronic address:

LncRNAs have been proven to play crucial roles in various processes of breast cancer. LncRNA FGF13-AS1 has been identified as one of the 25 downregulated lncRNAs in breast cancer through analyzing data from two cohorts and TCGA by another group of our lab. In this study, we report that FGF13-AS1 expression is decreased in breast cancer tissue compared with corresponding normal tissue, and the downregulation of FGF13-AS1 is associated with poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2019.02.008DOI Listing
February 2019

Sequential activation of anticancer therapy triggered by tumor microenvironment-selective imaging.

J Control Release 2019 Feb 13. Epub 2019 Feb 13.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

The combination of imaging and anticancer therapy has recently emerged as a promising strategy. However, nonspecific imaging signals and distribution of anticancer drugs at normal tissues limit the specificity of the combination therapy. To overcome the challenges, we designed a system which can selectively visualize cancer tissues and initiate the subsequent action of therapeutic molecules in tumor microenvironment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2019.02.012DOI Listing
February 2019

Interactions between plasmids and other mobile genetic elements affect their transmission and persistence.

Plasmid 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, P.O. Box 6050, Langnes, Tromsø, Norway. Electronic address:

Plasmids are genetic elements that play a role in bacterial evolution by providing new genes that promote adaptation to diverse conditions. Plasmids are also known to reduce bacterial competitiveness in the absence of selection for plasmid-encoded traits. It is easier to understand plasmid persistence when considering the evidence that plasmid maintenance can improve during co-evolution with the bacterial host, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plasmid.2019.01.003DOI Listing
February 2019

Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Pharmaceutical Sciences, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra 411038, India.

Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2019.02.022DOI Listing
February 2019

Development of a sandwich enzyme-linked immunosorbent assay for the quantification of ponatinib in serum.

Anal Biochem 2019 Feb 13. Epub 2019 Feb 13.

Applied Life Science Department, Faculty of Biotechnology and Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto, 860-0082, Japan.

The tyrosine kinase inhibitor ponatinib is extensively metabolized in the body, and consequently the development of specific immunoassays for pharmacokinetic studies and therapeutic drug monitoring of ponatinib is challenging. If two antibodies simultaneously recognize the entire structure of ponatinib, they could be utilized to establish an ultra-specific sandwich immunoassay for ponatinib, free of any interference from ponatinib metabolites. In this study, we created two types of anti-ponatinib polyclonal antibodies that recognize two different ponatinib epitopes, and sandwiched almost all structural components of ponatinib in these two antibodies in order to develop an enzyme-linked immunosorbent assay (ELISA) technique not affected by any ponatinib metabolites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2019.02.010DOI Listing
February 2019
1 Read

Reduced levels of modified nucleosides in the urine of autistic children. Preliminary studies.

Anal Biochem 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, Institute of General and Ecological Chemistry, Lodz University of Technology, Lodz, Poland. Electronic address:

The aim of this study was to investigate and compare the levels of concentration of modified nucleosides in the urine of autistic and healthy children. The compounds have never been analyzed before. The levels of nucleosides in the urine of both groups were determined by validated high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) method using multiple reaction monitoring (MRM) mode. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2019.02.009DOI Listing
February 2019

Aegle marmelos leaf extract ameliorates the cognitive impairment and oxidative stress induced by intracerebroventricular streptozotocin in male rats.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Sector-125, Noida 201313, India. Electronic address:

Aims: Aegle marmelos (L.) Correa (A. marmelos) has been used in Ayurvedic medicine as a brain tonic however its neuroprotective effect against streptozotocin (STZ) induced cognitive impairment and oxidative stress has not been reported yet in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.02.032DOI Listing
February 2019

Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology and Psychopharmacology Research Unit, Marmara University School of Pharmacy, Istanbul, Turkey.

Aims: The effects of agmatine, an endogenous substance known to have a neuroprotective effect against neurotoxicity has been investigated.

Material And Methods: The primary neuron culture obtained from neonatal rats was exposed to toxicity with paclitaxel and cisplatin and the effect of agmatine on both acute (1 h) and chronic (24 h) exposure was demonstrated by biochemical and molecular analyses. It was demonstrated that the effect of agmatine before and after agmatine was induced by neurotoxicity before agmatine and the effect of agmatine on the formed and occuring toxicities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.02.018DOI Listing
February 2019

Drug-Drug Interactions of Infectious Disease Treatments in Low Income Countries: A Neglected Topic?

Clin Pharmacol Ther 2019 Feb 16. Epub 2019 Feb 16.

The Bill & Melinda Gates Foundation, Seattle, Washington, USA.

Despite recent advances in recognizing and reducing the risk of drug-drug interactions (DDIs) in developed countries, there are still significant challenges in managing DDIs in low income countries (LICs) worldwide. In the treatment of major infectious diseases in these regions, multiple factors contribute to ineffective management of DDIs that lead to loss of efficacy or increased risk of adverse events to patients. Some of these difficulties, however, can be overcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1397DOI Listing
February 2019

Stem Cells from Human Extracted Deciduous Teeth Expanded in Foetal Bovine and Human Sera Express Different Paracrine Factors After Exposure to Freshly Prepared Human Serum.

Adv Exp Med Biol 2019 Feb 16. Epub 2019 Feb 16.

Regenerative Dentistry Research Group, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Background: The response of stem cells to paracrine factors within the host's body plays an important role in the regeneration process after transplantation. The aim of this study was to determine the viability and paracrine factor profile of stem cells from human extracted deciduous teeth (SHED) pre-cultivated in media supplemented with either foetal bovine serum (FBS) or pooled human serum (pHS) in the presence of individual human sera (iHS).

Methods: SHED (n = 3) from passage 4 were expanded in FBS (FBS-SHED) or pHS (pHS-SHED) supplemented media until passage 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/5584_2018_299DOI Listing
February 2019

Community pharmacists' role in preventing opioid substitution therapy-related deaths: a qualitative investigation into current UK practice.

Int J Clin Pharm 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy and Pharmacology, University of Bath, C/O: 5 West 3.26, Claverton Down, Bath, BA2 7AY, UK.

Background Opioid substitution therapy involves prescribing of medical substitutes like methadone and buprenorphine to patients who are addicted to opioids. The majority of opioid substitution therapy dispensing in the UK is done by community pharmacists and they often see the patients on daily basis. It is unknown to what extent community pharmacists implement the policy to prevent overdose in patients receiving such treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11096-019-00790-xDOI Listing
February 2019

Impact of the CYP2D6 phenotype on hyperprolactinemia development as an adverse event of treatment with atypical antipsychotic agents in pediatric patients.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Discipline of Medical Genetics, Department of Microscopic Morphology, Victor Babeş University of Medicine and Pharmacy Timișoara, Timișoara, Romania.

Background: Treatment with atypical antipsychotics is today the election therapy for different types of psychosis, but there is a high incidence of endocrine and metabolic disturbances. One of the major enzymes involved in the metabolism of antipsychotics is CYP2D6. Depending on the existing CYP2D6 alleles, the metabolic capacity of the enzyme may vary from very low to very high, so that patients can be grouped into four phenotypic groups: slow, intermediate, extensive (normal), and fast metabolizers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11845-019-01985-xDOI Listing
February 2019

CoO/carbon hollow nanospheres for resistive monitoring of gaseous hydrogen sulfide and for nonenzymatic amperometric sensing of dissolved hydrogen peroxide.

Mikrochim Acta 2019 Feb 15;186(3):184. Epub 2019 Feb 15.

Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science, Heilongjiang University, Harbin, 150080, China.

CoO/carbon hybrid hollow nanospheres (hs-CoO/C) with an empty cavity and a thin shell, were synthesized starting from the pectin and cobalt acetate via cross-linking deposition at room temperature and post-calcination. The hierarchical structure is constructed from the interconnected nanoparticles in the residual carbon matrix, and the carbon content can be adjusted by changing the calcination temperature. The gas sensor based on hs-CoO/C calcined at 300 °C in air shows high response towards 50 ppm of HS (S = 95. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3253-8DOI Listing
February 2019

Regulatory effects of paeoniflorin-6'-O-benzene sulfonate (CP-25) on dendritic cells maturation and activation via PGE2-EP4 signaling in adjuvant-induced arthritic rats.

Inflammopharmacology 2019 Feb 15. Epub 2019 Feb 15.

Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease. Dendritic cells (DCs) are one of the most powerful antigen-presenting cells, and they play an important role in RA pathogenesis. Prostaglandin E2 (PGE2) is a potent lipid mediator that can regulate the maturation and activation of DCs, but the molecular mechanisms have not been elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10787-019-00575-8DOI Listing
February 2019

Responses of olive plants exposed to different irrigation treatments in combination with heat shock: physiological and molecular mechanisms during exposure and recovery.

Planta 2019 Feb 15. Epub 2019 Feb 15.

Department of Life Science, Centre for Functional Ecology (CFE), University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.

Main Conclusion: A water-deficit period, leading to stomatal control and overexpression of protective proteins (sHSP and DHN), contributes to olive´s tolerance to later imposed stress episodes. Aquaporins modulation is important in olive recovery. Olive is traditionally cultivated in dry farming or in high water demanding irrigated orchards. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00425-019-03109-2DOI Listing
February 2019

Delivery Systems as Vital Tools in Drug Repurposing.

AAPS PharmSciTech 2019 Feb 15;20(3):116. Epub 2019 Feb 15.

Advanced Drug Delivery Laboratory, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, Ohio, 44272, USA.

The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12249-019-1333-zDOI Listing
February 2019

Vanadium elicitation of Trifolium pratense L. cell culture and possible pathways of produced isoflavones transport across the plasma membrane.

Plant Cell Rep 2019 Feb 15. Epub 2019 Feb 15.

Department of Botany and Plant Physiology, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, 165 00, Prague, Czech Republic.

Key Message: Vanadium compounds increased the content and release of distinct isoflavones in a Trifolium pratense suspension culture. Regarding transport-mechanism inhibitors, the process was mostly facilitated by ABC proteins and vesicular transport. The transport of isoflavones and other secondary metabolites is an important part of metabolism within plants and cultures in vitro regarding their role in defence against various abiotic and biotic stressors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00299-019-02397-yDOI Listing
February 2019

Risk factors for vancomycin nephrotoxicity and time course of renal function during vancomycin treatment.

Eur J Clin Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, Tokyo, 116-0011, Japan.

Purpose: Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. We assessed risk factors for VCM nephrotoxicity and how renal function varied over time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00228-019-02648-7DOI Listing
February 2019

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Nat Commun 2019 Feb 15;10(1):797. Epub 2019 Feb 15.

Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, 28029, Madrid, Spain.

FXR1 is an alternatively spliced gene that encodes RNA binding proteins (FXR1P) involved in muscle development. In contrast to other tissues, cardiac and skeletal muscle express two FXR1P isoforms that incorporate an additional exon-15. We report that recessive mutations in this particular exon of FXR1 cause congenital multi-minicore myopathy in humans and mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08548-9DOI Listing
February 2019

Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling.

Exp Mol Med 2019 Feb 15;51(2):18. Epub 2019 Feb 15.

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s12276-019-0217-3DOI Listing
February 2019

EVI1 promotes epithelial-to-mesenchymal transition, cancer stem cell features and chemo-/radioresistance in nasopharyngeal carcinoma.

J Exp Clin Cancer Res 2019 Feb 15;38(1):82. Epub 2019 Feb 15.

Department of Radiotherapy, People's Hospital of Shanxi Province, Taiyuan, China.

Background: Aberrant EVI1 expression is frequently reported in cancer studies; however, its role in nasopharyngeal carcinoma (NPC) has not been examined in detail. The aim of the present study is to investigate the involvement of EVI1 in progression and prognosis of NPC.

Methods: RT-PCR, immunohistochemistry and western blot assays were used to examine the expression of EVI1 in NPC tissues and cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13046-019-1077-3DOI Listing
February 2019

Repeat hepatectomy with systemic chemotherapy might improve survival of recurrent liver metastasis from colorectal cancer-a retrospective observational study.

World J Surg Oncol 2019 Feb 15;17(1):33. Epub 2019 Feb 15.

Department of Surgery Fujita Health University, 1-98 Dengakugakubo Kutsukake-cho, Toyoake City, Aichi, 470-1192, Japan.

Background: Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery, and palliative care. On the other hand, development of chemotherapeutic agents is remarkable and improves long-term survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12957-019-1575-yDOI Listing
February 2019

Epidemiological characteristics and trends of a Nationwide measles outbreak in Mongolia, 2015-2016.

BMC Public Health 2019 Feb 15;19(1):201. Epub 2019 Feb 15.

Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Mongolia was one of the four countries that received a measles-elimination certificate from the World Health Organization Regional Office for the Western Pacific in 2014. Following the outbreaks in many countries including China, a large measles outbreak occurred in Mongolia in 2015. This study reports 2015-2016 measles outbreak incidence, mortality, and complications, according to time, geographical distribution, and host characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-019-6511-0DOI Listing
February 2019

Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.

Lipid metabolism disorders lead to vascular endothelial injury. Matrine is an alkaloid that has been used to improve obesity and diabetes and for the treatment of hepatitis B. However, its effect on lipid metabolism disorders and vascular injury is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.14180DOI Listing
February 2019

Evaluation of tools for annual capture of adherence to immunosuppressive medications after renal transplantation.

Transpl Int 2019 Feb 15. Epub 2019 Feb 15.

Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Background: Annual assessment of adherence would strengthen long-term outcome assessments from registry data. The objective of this study was to evaluate tools suitable for annual routine capture of adherence data in renal transplant recipients.

Methods: A single centre open prospective trial included 295 renal transplant recipients on tacrolimus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tri.13412DOI Listing
February 2019

Use of stem cells as carriers of oncolytic viruses for cancer treatment.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Therapeutic application of stem cells and oncolytic viruses in cancer treatment has rapidly increased in the last decade. Oncolytic viruses are considered as a new class of anticancer agents because of their ability to selectively infect and destroy cancer cells. Furthermore, regarding the specific migratory capacity of stem cells, they can be used as carriers or vectors targeting metastatic cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28320DOI Listing
February 2019

Advancing stiffness measurement in rheumatic disease: report from the Stiffness Special Interest group at OMERACT 2018.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From Johns Hopkins University School of Medicine, Baltimore, MD USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK; McGill University, Montreal, Quebec, Canada; Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA; Division of Medicine, The University of Adelaide, Adelaide, Australia Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia; Horizon Pharma, Inc, Lake Forest, Illinois, USA and Adjunct Professor, College of Pharmacy, University of Illinois, Chicago, IL, USA; Healthy Motivation, Bone and Joint Decade Global Alliance for Musculoskeletal Health, Santa Barbara, California, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Singapore General Hospital, Duke-NUS Medical School; University of Bristol, Bristol, UK; University of West England - Bristol, Bristol, UK. AMO is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. Work from the US Cohort was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award numbers [P30-AR070254 Core B] and [P30-AR053503 Core D] and Patient Centered Outcomes Research Institute (PCORI) Pilot Project Award number [IP2-PI000737], and the Camille Julia Morgan Arthritis Research and Education Fund. All statements in this report including its conclusions are the opinions of the authors and do not necessarily reflect those of PCORI, its board of governors, or its methodology committee, or of NIH or NIAMS. RH is an employee of Horizon Pharma, LLC; CK is an employee of Janssen Scientific Affairs, LLC. Address correspondence to Ethan T Craig, 3900 Woodland Ave., Philadelphia, PA 19104. Email:

Objective: To improve measurement of stiffness in rheumatic disease.

Methods: Data presented included: 1) Two qualitative projects; 2) The RA Stiffness patient-reported outcome measure (RAST); 3) three items assessing stiffness severity, duration, and interference. 3) RESULTS: Stiffness is multidimensional and includes aspects of stiffness experience such as duration, severity, and impact. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.181074DOI Listing
February 2019

Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, and the Department of Medicine, Division of Rheumatology, and the School of Pharmacy, at the University of California, San Francisco (UCSF), San Francisco, California; Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, Ohio; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by UCB Pharmaceutical Inc. (Xiaojuan Li). T. Shimizu, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; A. Cruz, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, and School of Pharmacy, UCSF; M. Tanaka, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; K. Mamoto, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Biomedical Engineering, PAMI, Cleveland Clinic; V. Pedoia, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; A.J. Burghardt, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; U. Heilmeier, MD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; T.M. Link, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; J. Graf, MD, Department of Medicine, Division of Rheumatology, UCSF; J.B. Imboden, MD, Department of Medicine, Division of Rheumatology, UCSF; X. Li, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Biomedical Engineering, PAMI, Cleveland Clinic. Address correspondence to Dr. T. Shimizu, Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. E-mail: Accepted for publication October 24, 2018.

Objective: To investigate the correlation between changes in radiological quantitative assessment with changes in clinical and functional assessment from baseline to 3 months in patients with rheumatoid arthritis (RA).

Methods: Twenty-eight patients with RA [methotrexate (MTX) and anti-tumor necrosis factor-α (TNF-α) group with high disease activity (n = 18); and MTX group with low disease activity (n = 10)] underwent assessments at baseline and 3 months: clinical [28-joint count Disease Activity Score (DAS28)], functional [Health Assessment Questionnaire (HAQ) and Michigan Hand Outcome Questionnaire (MHQ)], and imaging-based [3 Tesla magnetic resonance imaging (MRI) and high-resolution peripheral quantitative computed tomography (HR-pQCT)]. MR images were evaluated semiquantitatively [RA MRI scoring (RAMRIS)] and quantitatively for the volume of synovitis and bone marrow edema (BME) lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.180496DOI Listing
February 2019

A Validation study of the Limulus Amebocyte Lysate test as an end-product endotoxin test for Polyvalent Horse Snake Antivenom.

PDA J Pharm Sci Technol 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Snake antivenoms are the only definitive management of snake envenoming's. Endotoxin contamination is a serious threat to the safety of parenteral drugs. A greater understanding of the nature of LAL-Test interferences and the use permissible dilutions has minimized enhancement problems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5731/pdajpst.2018.009522DOI Listing
February 2019

Validation of an algorithm for identifying MS cases in administrative health claims datasets.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Veterans Affairs Post Deployment Health Services (W.J.C., M.T.W.), Multiple Sclerosis Center of Excellence; University of Maryland (W.J.C.), Baltimore; Departments of Internal Medicine and Community Health Sciences (R.A.M., S.L.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Neurology Department (A.L.-G., L.H.C.), Kaiser Permanente Southern California, Los Angeles; Georgetown University School of Medicine (M.T.W.), Washington, DC; University of Colorado (J.C.), Denver; Stanford University School of Medicine (L.M.N.), CA; McKing Consulting Corp (W.E.K., L.W.), Atlanta, GA; Faculty of Medicine (Neurology) and Centre for Brain Health (H.T.), University of British Columbia, Vancouver; College of Pharmacy and Nutrition (C.E.), University of Saskatchewan; Health Quality Council (Saskatchewan) (S.Y.), Saskatoon, Canada; and National Multiple Sclerosis Society (N.G.L.), New York, NY.

Objective: To develop a valid algorithm for identifying multiple sclerosis (MS) cases in administrative health claims (AHC) datasets.

Methods: We used 4 AHC datasets from the Veterans Administration (VA), Kaiser Permanente Southern California (KPSC), Manitoba (Canada), and Saskatchewan (Canada). In the VA, KPSC, and Manitoba, we tested the performance of candidate algorithms based on inpatient, outpatient, and disease-modifying therapy (DMT) claims compared to medical records review using sensitivity, specificity, positive and negative predictive values, and interrater reliability (Youden J statistic) both overall and stratified by sex and age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007043DOI Listing
February 2019