3,211 results match your criteria Journal of molecular neuroscience : MN[Journal]


LATS2 Inhibits Malignant Behaviors of Glioma Cells via Inactivating YAP.

J Mol Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Institute of Nervous System Diseases, Xuzhou Medical University, 84 West Huai-hai Road, Xuzhou, 221002, Jiangsu, People's Republic of China.

We previously reported that LATS2, the upstream serine/threonine kinase of Yes-associated protein (YAP), is downregulated in gliomas and exhibits negative correlation with the prognosis of glioma patients. In this work, we aimed to explore the role and mechanism of large tumor suppressor kinase (LATS2) in the progression of malignant gliomas. We found that over-expression of LATS2 inhibited glioma cell proliferation and migration/invasion, while LATS2 downregulation promoted them. Read More

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http://dx.doi.org/10.1007/s12031-019-1262-zDOI Listing
February 2019

Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome.

J Mol Neurosci 2019 Feb 13. Epub 2019 Feb 13.

Genetics & Regenerative Medicine Research Centre (GRMRC), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Notch signalling pathway is involved in the proliferation of neural progenitor cells (NPCs), to inhibit neuronal cell commitment and to promote glial cell fate. Notch protein is cleaved by gamma-secretase, a multisubunit transmembrane protein complex that releases the Notch intracellular domain (NICD) and subsequently activates the downstream targets. Down syndrome (DS) individuals exhibit an increased number of glial cells (particularly astrocytes), and reduced number of neurons suggesting the involvement of Notch signalling pathway in the neurogenic-to-gliogenic shift in DS brain. Read More

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http://dx.doi.org/10.1007/s12031-019-01275-2DOI Listing
February 2019
1 Read

Curcumin Alleviates β Amyloid-Induced Neurotoxicity in HT22 Cells via Upregulating SOD2.

J Mol Neurosci 2019 Feb 12. Epub 2019 Feb 12.

Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, China.

Curcumin protects neuronal cells exposed to β amyloid (Aβ); the mechanism, however, is still obscure. The aim of this study is to determine whether the type 2 superoxide dismutase (SOD2) mediates curcumin-induced protective effects in Aβ-treated neuronal cells. In this study, the HT22 neuronal cells were exposed to Aβ to imitate neuronal injury in Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1007/s12031-019-01267-2DOI Listing
February 2019

Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury.

J Mol Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Department of Anatomy and Anthropology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Traumatic brain injury (TBI) is one of the most common causes of neurological damage in young people. It was previously reported that dietary restriction, by either intermittent fasting (IF) or daily caloric restriction (CR), could protect neurons against dysfunction and degeneration in animal models of stroke and Parkinson's disease. Recently, several studies have shown that the protein Sirtuin 1 (SIRT1) plays a significant role in the induced neuroprotection following dietary restriction. Read More

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http://dx.doi.org/10.1007/s12031-019-01271-6DOI Listing
February 2019
2 Reads

Treatment with MQA, a Derivative of Caffeoylquinic Acid, Provides Neuroprotective Effects against Cerebral Ischemia Through Suppression of the p38 Pathway and Oxidative Stress in Rats.

J Mol Neurosci 2019 Feb 8. Epub 2019 Feb 8.

School of Pharmacy, Ministry of Education, Shihezi University/Key Laboratory of Xingjiang Phytomedicine Resources Utilization, Shihezi, China.

1,5-O-dicaffeoyl-3-O-(4-malic acid methylester)-quinic acid (MQA), extracted from Arctium lappa L., has been observed to exert neuroprotective effects in vitro. The aim of this study was to investigate whether MQA is an effective therapeutic method for cerebral ischemic injury in vivo. Read More

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http://dx.doi.org/10.1007/s12031-019-01268-1DOI Listing
February 2019

Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway.

Authors:
Ruisi Tian Shu Wang

J Mol Neurosci 2019 Feb 6. Epub 2019 Feb 6.

Institute of Acupuncture and Moxibustion, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No.314 West Anshan Road, Nankai District, 300193, Tianjin, China.

This study is designed to explore the effect of electric acupuncture on the apoptosis of hippocampal neurons through the Notch3 signaling pathway. A middle cerebral artery occlusion (MCAO) mouse model was generated by thread embolization. A Y-maze was used to test cognitive function (learning and memory). Read More

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http://dx.doi.org/10.1007/s12031-018-1253-5DOI Listing
February 2019

Inhibition of BECN1 Suppresses Lipid Peroxidation by Increasing System X Activity in Early Brain Injury after Subarachnoid Hemorrhage.

J Mol Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Neurosurgery, Zhoukou Central Hospital, No. 26 Renmin Road, Zhoukou City, 466000, Henan Province, China.

Lipid peroxidation plays a crucial role in early brain injury (EBI) after subarachnoid hemorrhage (SAH), and cystine/glutamate antiporter system X has been proved to be associated with glutathione (GSH) synthesis, which protects cells against oxidative damage. Antioxidant effect of system X is mediated by Beclin 1 (BECN1). Therefore, this study aimed to determine whether administration of BECN1 small interfering RNA (siRNA) could attenuate EBI after SAH experiment, specifically through suppressing lipid peroxidation and increasing system X activity. Read More

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http://dx.doi.org/10.1007/s12031-019-01272-5DOI Listing
February 2019
2 Reads

Biochemical Analysis and Association of Butyrylcholinesterase SNPs rs3495 and rs1803274 with Substance Abuse Disorder.

J Mol Neurosci 2019 Feb 1. Epub 2019 Feb 1.

Department of Biosciences, Functional Proteomics and Genomics Lab, COMSATS University Islamabad, Islamabad, Pakistan.

Addiction is a complex mental and behavioral disorder that changes the neurochemistry and physiology of the brain. Genetics also plays a significant role in the pathophysiology of addiction. Butyrylcholinesterase (BChE), a cholinergic enzyme, has been implicated in the metabolism of various drugs, including cocaine, and an association between single-nucleotide polymorphisms (SNPs) of the butyrylcholinesterase gene (BCHE) and neuronal disorders has been reported. Read More

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http://dx.doi.org/10.1007/s12031-018-1251-7DOI Listing
February 2019

Two Novel CCM2 Heterozygous Mutations Associated with Cerebral Cavernous Malformation in a Chinese Family.

J Mol Neurosci 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurology, West China Hospital, Sichuan University, Guo Xuexiang #37, Chengdu, 610041, China.

Cerebral cavernous malformation (CCM) is a congenital vascular anomaly that predominantly involves the central nervous system (CNS). CCM occurs in either a sporadic or an inherited form; the latter is called familial cerebral cavernous malformation (FCCM). FCCM has an autosomal dominant transmission with incomplete penetrance and variable clinical expression that is associated with germline mutations in the CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10 genes. Read More

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http://dx.doi.org/10.1007/s12031-018-1254-4DOI Listing
January 2019
1 Read

Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment.

J Mol Neurosci 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, Fujian Medical University Union Hospital, Xinquan Road 29#, Fuzhou, 350001, China.

Cognitive impairment is a common comorbidity in patients with temporal lobe epilepsy (TLE) that severely affects patients' quality of life. Also, serotonin 5-hydroxytryptamine 6 (5-HT6) receptor plays an important role in cognition. This study aimed to investigate effects of 5-HT6 receptor on learning-memory capacities in epileptic rats. Read More

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http://link.springer.com/10.1007/s12031-018-1238-4
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http://dx.doi.org/10.1007/s12031-018-1238-4DOI Listing
January 2019
3 Reads

Alterations of White Matter Integrity in Subcortical Ischemic Vascular Disease with and Without Cognitive Impairment: a TBSS Study.

J Mol Neurosci 2019 Jan 26. Epub 2019 Jan 26.

The Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Patients with subcortical ischemic vascular disease (SIVD) may exhibit a high risk of cognitive impairment (CI) by disruption of white matter (WM) integrity. Diffusion tensor imaging (DTI) is recommended as a sensitive method to explore whole brain WM alterations at an asymptomatic stage of the disease, which might be correlated with underlying cognitive disorders. We aim to investigate alterations in WM microstructures and evaluate the relationships between the mean values of diffusion metrics (FA, MD, AD, and RD) and cognitive assessments in SIVD patients. Read More

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http://dx.doi.org/10.1007/s12031-019-01266-3DOI Listing
January 2019
1 Read

N-Acetyl Serotonin Protects Neural Progenitor Cells Against Oxidative Stress-Induced Apoptosis and Improves Neurogenesis in Adult Mouse Hippocampus Following Traumatic Brain Injury.

J Mol Neurosci 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurosurgery, Hainan General Hospital, 19 Xiuhua Road, Xiuying District, Haikou, 570311, Hainan Province, China.

In this study, with primary mouse neural progenitor cells (NPCs), we investigated the neuroprotective effect of a tropomyosin-related kinase receptor B (TrkB) agonist, N-acetyl serotonin (NAS), against hydrogen peroxide (HO)-induced toxicity. We found that pre-incubation with NAS not only ameliorates HO-induced cell viability loss, lactate dehydrogenase (LDH) release, and proliferative and migratory capacity impairments, but counteracts HO-triggered production of nitric oxide (NO), reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxy-deoxyguanosine (8-OHdG) in a dose-dependent manner. Additionally, pre-treatment with NAS was able to attenuate HO-induced apoptosis in NPCs, evidenced by the decreased percentage of apoptotic cells and altered expression of apoptosis-related factors. Read More

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http://dx.doi.org/10.1007/s12031-019-01263-6DOI Listing
January 2019
1 Read

The Effect of Neuronal Activity on Glial Thrombin Generation.

J Mol Neurosci 2019 Jan 25. Epub 2019 Jan 25.

Laboratory for Neurology Research Department of Neurology and the Joseph Sagol Neuroscience Center, Chaim Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel.

Thrombin through its receptor PAR-1 plays an important role in the peripheral nervous system. PAR-1 is located at the microvilli of Schwann cells at the node of Ranvier, and thrombin is generated by the coagulation system on these glial structures. In the present study, we examined the link between neuronal activity and modulation of thrombin generation by glial Schwann cells. Read More

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http://dx.doi.org/10.1007/s12031-019-01265-4DOI Listing
January 2019
2 Reads

Investigation of Neuregulin-1 and Glial Cell-Derived Neurotrophic Factor in Rodent Astrocytes and Microglia.

J Mol Neurosci 2019 Jan 25. Epub 2019 Jan 25.

Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Growth factors play a crucial role during de- and remyelination of the central nervous system (CNS) due to their neurotrophic functions. We have previously shown that the growth factors neuregulin-1 (Nrg-1) and glial cell-derived neurotrophic factor (Gdnf) are upregulated during the first 2 weeks after induction of toxic demyelination in the CNS. Nevertheless, the factors responsible for Nrg-1/Gdnf upregulation and their effects on glia cells are unknown. Read More

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http://dx.doi.org/10.1007/s12031-019-1258-8DOI Listing
January 2019
1 Read

Lack of Association of the rs11655081 ARSG Gene with Blepharospasm.

J Mol Neurosci 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.

Blepharospasm (BSP) is a sub-phenotype of focal dystonia. A few genetic risk factors are considered to be implicated in the risk of developing BSP. There is recent evidence, based on results from GWAS and meta-analyses, to suggest that arylsulfatase G (ARSG), and more specifically rs11655081, is implicated in focal dystonia. Read More

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http://dx.doi.org/10.1007/s12031-018-1255-3DOI Listing
January 2019

Role of PDGF-A-Activated ERK Signaling Mediated FAK-Paxillin Interaction in Oligodendrocyte Progenitor Cell Migration.

J Mol Neurosci 2019 Jan 16. Epub 2019 Jan 16.

Division of Neurobiology, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, Gujarat, 390002, India.

Oligodendrocyte progenitor cells (OPCs) originate from the sub-ventricular zone of the developing brain. They migrate and proliferate to occupy the white matter tracts of the central nervous system and transform into myelinating oligodendrocytes. Along their route of migration, OPCs are guided and controlled by several growth factors and chemokines. Read More

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http://dx.doi.org/10.1007/s12031-019-1260-1DOI Listing
January 2019

Protective Role of SOCS3 Modified Bone Marrow Mesenchymal Stem Cells in Hypoxia-Induced Injury of PC12 Cells.

J Mol Neurosci 2019 Jan 15. Epub 2019 Jan 15.

Department of Infection, Linyi Central Hospital, Linyi, 276400, Shandong, China.

We attempted to explore the possible effects of SOCS3 (suppressor of cytokine signaling 3)-modified bone marrow mesenchymal stem cells (BMSCs) on the hypoxic injury of rat adrenal gland pheochromocytoma (PC-12) cells. PC12 cells were cultured with EGFP (enhanced green fluorescent protein)-BMSCs and SOCS3-BMSCs respectively under hypoxia in vitro and classified into control, hypoxia, EGFP-BMSCs, and SOCS3-BMSC groups. CCK-8, Hoechst 33258 staining, and Annexin V-FITC/PI staining were assessed to measure the viability and apoptosis of hypoxia-induced PC12 cells. Read More

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http://dx.doi.org/10.1007/s12031-018-1243-7DOI Listing
January 2019
1 Read

Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation.

J Mol Neurosci 2019 Jan 15. Epub 2019 Jan 15.

Department of Neurology, The Second Affiliated Hospital of Jiaxing University, No 1518 the North Road around the city, Jiaxing, 314000, Zhejiang, China.

Although histamine inhibitors have been used in the motility-associated vertigo, the link between histamine and sleep deprivation (SD)-induced vertigo has not been clearly demonstrated. The histamine plasma levels were assayed in the SD volunteers before SD and 24 h after SD. Pinnacle's automated sleep deprivation system was used to establish the female C57BL/6 mice SD model. Read More

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http://link.springer.com/10.1007/s12031-018-1244-6
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http://dx.doi.org/10.1007/s12031-018-1244-6DOI Listing
January 2019
5 Reads

TPPU, a sEH Inhibitor, Attenuates Corticosterone-Induced PC12 Cell Injury by Modulation of BDNF-TrkB Pathway.

J Mol Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Physiology, Luohe Medical College, Luohe, 462000, China.

High level of corticosterone (CORT) is toxic to neurons and plays an important role in depression-like behavior and chronic stress. Our previous study showed that TPPU, a soluble epoxide hydrolase (sEH) inhibitor (sEHI), induces an antidepressant effect in animal models. However, the underlying mechanism is not clear. Read More

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http://dx.doi.org/10.1007/s12031-018-1230-zDOI Listing
January 2019
2.343 Impact Factor

Gestational and Lactational Exposure to Malathion Affects Antioxidant Status and Neurobehavior in Mice Pups and Offspring.

J Mol Neurosci 2019 Jan 12. Epub 2019 Jan 12.

Biological Engineering Laboratory, Faculty of Sciences and Techniques, Sultan MoulaySlimane University, Beni Mellal, Morocco.

Environmental factors such as pesticides are considered key determinants of brain damage and brain dysfunction. In the present work, we investigated the effect of an organophosphate pesticide, i.e. Read More

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http://dx.doi.org/10.1007/s12031-018-1252-6DOI Listing
January 2019

Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease.

J Mol Neurosci 2019 Jan 11. Epub 2019 Jan 11.

The Joseph Sagol Neuroscience Center Tel-hashomer, 52621, Ramat-Gan, Israel.

Disruption of brain insulin signaling may explain the higher Alzheimer's disease (AD) risk among type 2 diabetic (T2D) patients. There is evidence from in vitro and human postmortem studies that combination of insulin with hypoglycemic medications is neuroprotective and associated with less amyloid aggregation. We examined the effect of 8-month intranasal administration of insulin, exenatide (a GLP-1 agonist), combination therapy (insulin + exenatide) or saline, in wild-type (WT) and an AD-like mouse model (Tg2576). Read More

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http://dx.doi.org/10.1007/s12031-019-1257-9DOI Listing
January 2019
1 Read

Amyloid Beta Adsorption Problem with Transfer Plates in Amyloid Beta 1-42 IVD Kits.

J Mol Neurosci 2019 Jan 11. Epub 2019 Jan 11.

Brain and Neurodegenerative Disorders Research Laboratory, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey.

Adsorption of CSF Aβ1-42 during pre-analytical processing is suggested as an important confounder in testing. The aim of the present study was to assess the effect of polypropylene transfer plates (PTP) in the INNOTEST Aβ1-42 IVD-ELISA assay on Aβ1-42 levels. CSF samples from 26 individuals with subjective cognitive impairment (SCI) and 25 patients with suspected neurodegenerative disorders were tested using four different lots of kits. Read More

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http://link.springer.com/10.1007/s12031-019-1261-0
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http://dx.doi.org/10.1007/s12031-019-1261-0DOI Listing
January 2019
3 Reads

Late Infantile Metachromatic Leukodystrophy Due to Novel Pathogenic Variants in the PSAP Gene.

J Mol Neurosci 2019 Jan 11. Epub 2019 Jan 11.

Department of Molecular and Biochemical Genetics - Centre of Rare Genetic Diseases, Comenius University Faculty of Medicine & University Hospital Bratislava, Bratislava, Slovakia.

Impairment of saposin B causes rare atypical metachromatic leukodystrophy (MLD). It is encoded (together with saposin A, C, and D) by the PSAP gene. Only ten pathogenic variants were described in the PSAP gene in MLD patients to date. Read More

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http://link.springer.com/10.1007/s12031-019-1259-7
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http://dx.doi.org/10.1007/s12031-019-1259-7DOI Listing
January 2019
5 Reads

The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice.

J Mol Neurosci 2019 Jan 10. Epub 2019 Jan 10.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.

Preconditioning is defined as an induction of adaptive response in organs against lethal stimulation provoked by subsequent mild sublethal stress. Several chemical agents have been demonstrated to cause brain tolerance through preconditioning. The aim of the present study is to test the hypothesis that preconditioning with pentylenetetrazole (PTZ) may have protective effect against seizure induced by i. Read More

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http://link.springer.com/10.1007/s12031-018-1256-2
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http://dx.doi.org/10.1007/s12031-018-1256-2DOI Listing
January 2019
5 Reads
2.343 Impact Factor

A Disease-Causing FRMD7 Variant in a Chinese Family with Infantile Nystagmus.

J Mol Neurosci 2019 Jan 8. Epub 2019 Jan 8.

Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, People's Republic of China.

In this report, we described a large Han-Chinese family which presents with various phenotypes from unaffected to manifested nystagmus in females. Infantile nystagmus (IN) is characterized by bilateral, involuntary, and periodic eyeball oscillation, occurring at birth or within the first 6 months. The most common inheritance pattern of IN is an X-linked form with incomplete penetrance among females, and the FERM domain containing 7 gene (FRMD7) is a main disease-causing gene. Read More

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http://link.springer.com/10.1007/s12031-018-1245-5
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http://dx.doi.org/10.1007/s12031-018-1245-5DOI Listing
January 2019
4 Reads

Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer's Disease.

J Mol Neurosci 2019 Jan 4. Epub 2019 Jan 4.

Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.

Soluble amyloid beta (Aβ) oligomers are the most common forms of Aβ in the early stage of Alzheimer's disease (AD). They are highly toxic to the neurons but their capability to activate microglia remains controversial. Microglia develop two distinct phenotypes, classic (M1) and alternative (M2). Read More

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http://dx.doi.org/10.1007/s12031-018-1249-1DOI Listing
January 2019
1 Read

A Novel Regulatory Function of Long Non-coding RNAs at Different Levels of Gene Expression in Multiple Sclerosis.

J Mol Neurosci 2019 Jan 4. Epub 2019 Jan 4.

Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Long non-coding RNAs (lncRNAs) play critical roles in regulation of immunological pathways. Consequently, their expression profile represents new biomarkers for susceptibility and progression of immunological disorders. However, their role in chronic inflammatory diseases such as multiple sclerosis (MS) remained unknown. Read More

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http://dx.doi.org/10.1007/s12031-018-1248-2DOI Listing
January 2019
2.343 Impact Factor

Microarray Data Analysis of Molecular Mechanism Associated with Stroke Progression.

J Mol Neurosci 2019 Jan 4. Epub 2019 Jan 4.

Department of Neurology, Fourth People's Hospital of Jinan, No. 50 Shifan Road, Tianqiao District, Jinan, 250031, Shandong Province, China.

This study aimed to explore the molecular mechanism of stroke and provide a new target in the clinical management. The miRNA dataset GSE97532 (3 blood samples from middle cerebral artery occlusion (MCAO) and 3 from sham operation) and mRNA dataset GSE97533 (3 blood samples from MCAO and 3 from sham operation) were obtained from GEO database. Differentially expressed mRNA (DEGs) and miRNAs (DEMIRs) were screened out between MCAO and sham operation groups. Read More

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http://dx.doi.org/10.1007/s12031-018-1247-3DOI Listing
January 2019

Inhibition of EPAC2 Attenuates Intracerebral Hemorrhage-Induced Secondary Brain Injury via the p38/BIM/Caspase-3 Pathway.

J Mol Neurosci 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.

Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway intermediaries that have been implicated in the pathogenesis of several human diseases, particularly neurological disorders. However, their pathogenic role in secondary brain injury (SBI) induced by intracranial hemorrhage (ICH) is unknown. The aim of this study was to examine the effects of EPAC2 on ICH-induced SBI and its underlying mechanisms. Read More

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http://dx.doi.org/10.1007/s12031-018-1215-yDOI Listing
January 2019
1 Read
2.343 Impact Factor

The Role of Vitamins in Autism Spectrum Disorder: What Do We Know?

J Mol Neurosci 2019 Jan 3. Epub 2019 Jan 3.

Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, Lodz, Poland.

Vitamin or mineral supplementation is considered to be the most commonly used medical treatment for autism spectrum disorder (ASD), in addition to other interventions such as neurological and psychological interventions. There is not much evidence of therapeutic efficacy between vitamin and mineral supplementation and improvements in ASD. However, several researchers have noted that patients with ASD have various metabolic and nutritional abnormalities including issues with sulfation, methylation, glutathione redox imbalances, oxidative stress, and mitochondrial dysfunction. Read More

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http://link.springer.com/10.1007/s12031-018-1237-5
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http://dx.doi.org/10.1007/s12031-018-1237-5DOI Listing
January 2019
5 Reads
2.343 Impact Factor

The α5-Containing GABA Receptors-a Brief Summary.

J Mol Neurosci 2019 Feb 3;67(2):343-351. Epub 2019 Jan 3.

Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kampus Kesihatan, 16150, Kubang Kerian, Kelantan, Malaysia.

GABA receptors are the major inhibitory neurotransmitter receptor in the human brain. The receptors are assembled from combination of protein subunits in pentameric complex which may consist of α1-6, β1-3, γ1-3, ρ1-3, δ, ε, θ, or π subunits. There are a theoretical > 150,000 possible assemblies and arrangements of GABA subunits, although only a few combinations have been found in human with the most dominant consists of 2α1, 2β2, and 1γ2 in a counterclockwise arrangement as seen from the synaptic cleft. Read More

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http://dx.doi.org/10.1007/s12031-018-1246-4DOI Listing
February 2019
1 Read

Lack of Major Ophthalmic Findings in Patients with Primary Familial Brain Calcification Linked to SLC20A2 and PDGFB.

J Mol Neurosci 2019 Jan 3. Epub 2019 Jan 3.

Keizo Asami Laboratory, Universidade Federal de Pernambuco, Recife, Brazil.

Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by symmetrical and bilateral brain calcification. It is typically inherited as an autosomal dominant disorder, and de novo variants have also been described. Interestingly, just recent studies have reported the first autosomal recessive PFBC-causative gene. Read More

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http://dx.doi.org/10.1007/s12031-018-1250-8DOI Listing
January 2019
1 Read

Network Profiling of Brain-Expressed X-Chromosomal MicroRNA Genes Implicates Shared Key MicroRNAs in Intellectual Disability.

J Mol Neurosci 2019 Feb 3;67(2):295-304. Epub 2019 Jan 3.

Servgen, Department of Genetics, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.

MicroRNAs are endogenous non-protein-coding RNA molecules that regulate post-transcriptional gene expression. The majority of human miRNAs are brain-expressed and chromosome X is enriched in miRNA genes. We analyzed the genomic regions of 12 brain-expressed pre-miRNAs located on chromosome X coding for 18 mature miRNAs, aiming to investigate the involvement of miRNA sequence variants on X-linked intellectual disability (XLID). Read More

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http://link.springer.com/10.1007/s12031-018-1235-7
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http://dx.doi.org/10.1007/s12031-018-1235-7DOI Listing
February 2019
3 Reads

GM1 Acupoint Injection Improves Mental Retardation in Children with Cerebral Palsy.

J Mol Neurosci 2019 Feb 2;67(2):305-311. Epub 2019 Jan 2.

Department of Children Rehabilitation Medicine, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

To study the clinical effectiveness and mechanism of GM1 acupoint injection therapy on mental retardation for children with cerebral palsy (CP). A total of 90 children with CP were divided into acupoint injection group (group A), subcutaneous injection group (group B), and control group (group C). Another 30 healthy children were set as a healthy control group (group D). Read More

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http://dx.doi.org/10.1007/s12031-018-1239-3DOI Listing
February 2019
1 Read

Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease.

J Mol Neurosci 2019 Feb 2;67(2):312-342. Epub 2019 Jan 2.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer 209, Bronx, NY, 10461, USA.

Sex differences in brain physiology and by inference various pathologies are generally recognized, however frequently ignored in epidemiological and experimental studies, leading to numerous data gaps. As a consequence, the mechanisms underlying sexual dimorphism of neurological diseases remain largely unknown. Several cellular and molecular pathways linked to the etiology and pathogenesis of various brain disorders have been recently described as sex-specific. Read More

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http://dx.doi.org/10.1007/s12031-018-1241-9DOI Listing
February 2019
1 Read

Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches.

J Mol Neurosci 2019 Feb 2;67(2):204-216. Epub 2019 Jan 2.

Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.

The present cross-sectional, hospital-based study was carried out on 146 Egyptian male children, 73 males with autism who were comparable with another 73 healthy age- and sex-matched children, recruited from the outpatients' psychiatric clinics of the Neuropsychiatric and Pediatric Departments of South Valley and Assiut University Hospitals, Egypt. Neuropsychological assessments of autistic males were done using CARS, short sensory profile and intelligent quotients. Serum markers of mitochondrial dysfunction (lactate, pyruvate, and lactate to pyruvate ratio, creatine kinase (CK), L-carnitine, ammonia, lactate dehydrogenase, pyruvate kinase, alanine transaminase and aspartate transaminase), oxidative stress and blood levels of heavy metals (mercury, lead and aluminium) were measured. Read More

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http://dx.doi.org/10.1007/s12031-018-1225-9DOI Listing
February 2019
3 Reads

Aberrant Expression of Long Non-coding RNAs in Peripheral Blood of Autistic Patients.

J Mol Neurosci 2019 Feb 18;67(2):276-281. Epub 2018 Dec 18.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Long non-coding RNAs (lncRNAs) constitute a large proportion of human transcriptome and are involved in fundamental aspects of neurodevelopment. In the present study, we evaluated expression levels of three lncRNAs, namely, Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), p21-associated ncRNA DNA damage-activated (PANDA), and taurine-upregulated gene 1 (TUG1), in peripheral blood of autism spectrum disorder (ASD) patients compared with those in healthy subjects. We found a significant upregulation of NEAT1 and TUG1 in ASD patients. Read More

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http://dx.doi.org/10.1007/s12031-018-1240-xDOI Listing
February 2019

HDAC9 Polymorphisms Predict Susceptibility, Severity, and Short-Term Outcome of Large Artery Atherosclerotic Stroke in Chinese Population.

J Mol Neurosci 2019 Jan 18;67(1):165-171. Epub 2018 Dec 18.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China.

Recently, a genome-wide association study (GWAS) detected two histone deacetylase 9 (HDAC9) polymorphisms (rs2074633 and rs28688791) which may be associated with risk of large artery atherosclerotic (LAA) stroke. This study aimed to investigate whether these two polymorphisms were associated with susceptibility, severity, and short-term outcome of LAA stroke in a southern Chinese Han population. rs2074633 and rs28688791 were genotyped using SNPscan technology in 1011 LAA stroke patients and 1121 healthy controls. Read More

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http://dx.doi.org/10.1007/s12031-018-1221-0DOI Listing
January 2019
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The Challenge to Search for New Nervous System Disease Biomarker Candidates: the Opportunity to Use the Proteogenomics Approach.

J Mol Neurosci 2019 Jan 15;67(1):150-164. Epub 2018 Dec 15.

Laboratory of Functional Genomics and Bioinformatics, Oswaldo Cruz Institute, Fundação Oswaldo Cruz (Fiocruz), Manguinhos, Rio de Janeiro, Brazil.

Alzheimer's disease, Parkinson's disease, prion diseases, schizophrenia, and multiple sclerosis are the most common nervous system diseases, affecting millions of people worldwide. The current scientific literature associates these pathological conditions to abnormal expression levels of certain proteins, which in turn improved the knowledge concerning normal and affected brains. However, there is no available cure or preventive therapy for any of these disorders. Read More

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http://dx.doi.org/10.1007/s12031-018-1220-1DOI Listing
January 2019
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TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1.

J Mol Neurosci 2019 Jan 13;67(1):97-110. Epub 2018 Dec 13.

Department of Biochemistry, Western University, Medical Sciences Building, Rm 342, 1151 Richmond St. North, London, ON, N6A 5C1, Canada.

Brain-derived neurotrophic factor (BDNF) facilitates multiple aspects of neuronal differentiation and cellular physiology by activating the high-affinity receptor tyrosine kinase, TrkB. While it is known that both BDNF and TrkB modulate cellular processes involved in learning and memory, exactly how TrkB cross-talks and modulates signaling downstream of excitatory ionotropic receptors, such as the NMDA receptor (NMDAR), are not well understood. A model that we have investigated involves the signaling molecule RasGrf1, a guanine nucleotide exchange factor for both Ras and Rac. Read More

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http://dx.doi.org/10.1007/s12031-018-1214-zDOI Listing
January 2019

Mitochondrial Impairment in Oligodendroglial Cells Induces Cytokine Expression and Signaling.

J Mol Neurosci 2019 Feb 13;67(2):265-275. Epub 2018 Dec 13.

Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.

Widespread inflammatory lesions within the central nervous system grey and white matter are major hallmarks of multiple sclerosis. The development of full-blown demyelinating multiple sclerosis lesions might be preceded by preactive lesions which are characterized by focal microglia activation in close spatial relation to apoptotic oligodendrocytes. In this study, we investigated the expression of signaling molecules of oligodendrocytes that might be involved in initial microglia activation during preactive lesion formation. Read More

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http://dx.doi.org/10.1007/s12031-018-1236-6DOI Listing
February 2019

Retinoprotective Effects of TAT-Bound Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase Activating Polypeptide.

J Mol Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Institute of Biomedicine, Jinan University, Guangzhou, China.

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) belong to the same peptide family and exert a variety of biological functions. Both PACAP and VIP have protective effects in several tissues. While PACAP is known to be a stronger retinoprotective peptide, VIP has very potent anti-inflammatory effects. Read More

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http://dx.doi.org/10.1007/s12031-018-1229-5DOI Listing
December 2018

TGF-β1 Restores Hippocampal Synaptic Plasticity and Memory in Alzheimer Model via the PI3K/Akt/Wnt/β-Catenin Signaling Pathway.

J Mol Neurosci 2019 Jan 12;67(1):142-149. Epub 2018 Dec 12.

Department of Neurology, the First Affiliated Hospital of Guangxi University of Chinese Medicine, No. 89-9 Dongge Road, Nanning, 530023, Guangxi, China.

Alzheimer's disease (AD) is the most common neurodegenerative disturbances. Dysfunction of synaptic plasticity and decline in cognitive functions are the most prominent features of AD, but the mechanisms of pathogenesis have not been well elucidated. In this paper, transforming growth factor-β1 (TGF-β1) was found to be reduced in the hippocampus of AD mouse which was accompanied by impaired pine density, synaptic plasticity, and memory function. Read More

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http://dx.doi.org/10.1007/s12031-018-1219-7DOI Listing
January 2019
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An Intraperitoneal Treatment with Calcitonin Gene-Related Peptide (CGRP) Regulates Appetite, Energy Intake/Expenditure, and Metabolism.

J Mol Neurosci 2019 Jan 10;67(1):28-37. Epub 2018 Dec 10.

CURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide expressed both centrally and peripherally. CGRP has been shown to be involved in arteriolar dilation, cardiovascular regulation, pain transmission, migraine, and gastrointestinal physiology. Our current research is aimed at analyzing CGRP's impact on appetite/satiety, body metabolism, and energy homeostasis. Read More

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http://dx.doi.org/10.1007/s12031-018-1202-3DOI Listing
January 2019
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Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

J Mol Neurosci 2019 Jan 7;67(1):62-71. Epub 2018 Dec 7.

Laboratory of Molecular Pharmacology, Jilin Provincial Key Laboratory of BioMacromolecules of Chinese Medicine, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.

The objective of this study was to investigate the neuroprotective and antioxidant effects of ginsenoside compound K (CK) in a model of scopolamine hydrobromide-induced, memory-impaired mice. The role of CK in the regulation of amyloid β (Aβ) and its capacity to activate the Nrf2/Keap1 signaling pathway were also studied due to their translational relevance to Alzheimer's disease. The Morris water maze was used to assess spatial memory functions. Read More

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http://dx.doi.org/10.1007/s12031-018-1210-3DOI Listing
January 2019
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Overexpression of SMN2 Gene in Motoneuron-Like Cells Differentiated from Adipose-Derived Mesenchymal Stem Cells by Ponasterone A.

J Mol Neurosci 2019 Feb 7;67(2):247-257. Epub 2018 Dec 7.

Applied Cell Sciences and Tissue Engineering Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Cell therapy and stem cell transplantation strategies have provided potential therapeutic approaches for the treatment of neurological disorders. Adipose-derived mesenchymal stem cells (ADMSCs) are abundant adult stem cells with low immunogenicity, which can be used for allogeneic cell replacement therapies. Differentiation of ADMSCs into acetylcholine-secreting motoneurons (MNs) is a promising treatment for MN diseases, such as spinal muscular atrophy (SMA), which is associated with the level of SMN1 gene expression. Read More

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http://dx.doi.org/10.1007/s12031-018-1232-xDOI Listing
February 2019
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Mitochondrial Electron Transport Chain Complex Dysfunction in MeCP2 Knock-Down Astrocytes: Protective Effects of Quercetin Hydrate.

J Mol Neurosci 2019 Jan 6;67(1):16-27. Epub 2018 Dec 6.

Division of Neurobiology, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.

Astrocytes play the central role in CNS metabolism to support neuronal functions. Mehyl-CpG-binding protein 2 (MeCP2) is the global transcription factor with differential expression in neuronal and non-neuronal cells. MeCP2 mutation and downstream detrimental effects have been reported in astrocytes also in MeCP2-associated neurodevelopmental disorder-Rett syndrome. Read More

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http://link.springer.com/10.1007/s12031-018-1197-9
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http://dx.doi.org/10.1007/s12031-018-1197-9DOI Listing
January 2019
17 Reads

Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders.

J Mol Neurosci 2019 Jan 5;67(1):89-96. Epub 2018 Dec 5.

Department of Medical Genetics, Erciyes University Medical Faculty, 38039, Kayseri, Turkey.

Autism spectrum disorder (ASD) is characterized by repetitive stereotypic behaviors, restricted interests, social withdrawal, and communication deficits. Aggression and insensitivity to pain are largely unexplained in these cases. We analyzed nine mRNA expressions of the candidate genes related to aggression and insensitivity to pain in the peripheral blood of patients with ASD. Read More

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http://link.springer.com/10.1007/s12031-018-1213-0
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http://dx.doi.org/10.1007/s12031-018-1213-0DOI Listing
January 2019
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Expression of mGlu Receptor Genes in the Hippocampus After Intoxication with Trimethyltin.

J Mol Neurosci 2019 Feb 30;67(2):258-264. Epub 2018 Nov 30.

Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Russia, 142290.

A variety of localization and signaling properties of eight subtypes of metabotropic glutamate receptors (mGluRs) in the brain provide glutamate an important regulatory role in many processes, including neurodegeneration and repair of neuronal damage. To identify specific subtypes of mGluRs, which are involved in neurodegeneration process, we assessed expression levels of their genes under pathophysiological conditions. Using quantitative real-time RT-PCR analysis, we studied transcription levels of mGlu2-5 and mGlu7 genes in the hippocampus after its damage by neurotoxicant trimethyltin chloride (TMT) in Wistar rats. Read More

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http://dx.doi.org/10.1007/s12031-018-1233-9DOI Listing
February 2019
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Amyloid Beta 1-42 Alters the Expression of miRNAs in Cortical Neurons.

J Mol Neurosci 2019 Feb 4;67(2):181-192. Epub 2018 Dec 4.

Brain and Neurodegenerative Disorders Research Laboratory, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey.

Recently, Aβ1-42 was demonstrated to have the potential to translocate into the nucleus and to be involved in the transcriptional regulation of certain neurodegeneration-related genes. This data raises the question of whether Aβ-induced neurodegeneration might include the expression of miRNAs. Thus, our aim in this study was to investigate the effects of Aβ1-42 on certain miRNAs which are related with vitamin D metabolism, neuronal differentiation, development, and memory. Read More

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http://dx.doi.org/10.1007/s12031-018-1223-yDOI Listing
February 2019