3,255 results match your criteria Journal of molecular neuroscience : MN[Journal]


RNA Sequencing of Peripheral Blood Revealed that the Neurotropic TRK Receptor Signaling Pathway Shows Apparent Correlation in Recovery Following Spinal Cord Injury at Small Cohort.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

Spinal cord injury (SCI) can be lethal; however, the precise mechanisms underlying healing are unclear, limiting the development of effective therapies. In this study, the molecular mechanisms involved in SCI were investigated. Clinical peripheral blood samples from normal individuals and patients with incomplete SCI (ISCI) and complete SCI (CSCI) were analyzed by RNA-Seq. Read More

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http://dx.doi.org/10.1007/s12031-019-01273-4DOI Listing

CADASIL with Atypical Clinical Symptoms, Magnetic Resonance Imaging, and Novel Mutations: Two Case Reports and a Review of the Literature.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Celal Bayar University, 45000, Manisa, Turkey.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy with adult onset caused by a missense mutation in the NOTCH3 gene in chromosome 19p13. It presents with autosomal dominant arteriopathy, subcortical infarctions, and leukoencephalopathy. Its common clinical presentations are seen as recurrent strokes, migraine or migraine-like headaches, progressive dementia, pseudobulbar paralysis, and psychiatric conditions. Read More

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http://dx.doi.org/10.1007/s12031-019-01313-zDOI Listing

PACAP Attenuates Optic Nerve Crush-Induced Retinal Ganglion Cell Apoptosis Via Activation of the CREB-Bcl-2 Pathway.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7 Jinsui Road, Guangzhou, 510623, China.

Retinal ganglion cell (RGC) apoptosis is considered an important pathological hallmark of glaucoma. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic peptide with potent neuroprotective properties. In our previous study, we found that the expression of PACAP and its high-affinity receptor PACAP receptor type 1 (PAC1R) increased markedly after optic nerve crush (ONC), and occurred mainly in the ganglion cell layer of the retina. Read More

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http://dx.doi.org/10.1007/s12031-019-01309-9DOI Listing

The Mechanism of Rap1 Regulates N-cadherin to Control Neuronal Migration.

J Mol Neurosci 2019 Apr 13. Epub 2019 Apr 13.

Xinxiang Key Laboratory of Neural Development, Stem Cells & Biotherapy Engineering Research Center of Henan, College of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, China.

Rap1 and N-cadherin regulate glia-independent translocation of cortical neurons. It remains unclear how Rap1 regulates N-cadherin-mediated neuronal migration. Here, we overexpressed Rap1gap in mouse brains (embryonic day 16) to inactivate Rap1, and observed that neurons did not migrate to the outer layer. Read More

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http://dx.doi.org/10.1007/s12031-019-01316-wDOI Listing

Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas.

J Mol Neurosci 2019 Apr 13. Epub 2019 Apr 13.

Biostatistics and Bioinformatics, Chanabasava Nilaya, Bharthinagar, Dharwad, Karnataka, 580001, India.

Non-functioning pituitary adenomas (NFPAs) are locally invasive with high morbidity. The objective of this study was to diagnose important genes and pathways related to the invasiveness of NFPAs and gain more insights into the underlying molecular mechanisms of NFPAs. The gene expression profiles of GSE51618 were downloaded from the Gene Expression Omnibus database with 4 non-invasive NFPA samples, 3 invasive NFPA samples, and 3 normal pituitary gland samples. Read More

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http://link.springer.com/10.1007/s12031-019-01318-8
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http://dx.doi.org/10.1007/s12031-019-01318-8DOI Listing
April 2019
1 Read

Downregulation of AIF-2 Inhibits Proliferation, Migration, and Invasion of Human Glioma Cells via Mitochondrial Dysfunction.

J Mol Neurosci 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.

Glioma remains the leading cause of brain tumor-related death worldwide. Apoptosis inducing factor (AIF) is a family of mitochondrial oxidoreductases that play important roles in mitochondrial metabolism and redox control. AIF-1 has been demonstrated to exert cell-killing effect via apoptosis in cancer cells, whereas the role of AIF-2 in cancer cells has not been determined. Read More

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http://dx.doi.org/10.1007/s12031-019-01306-yDOI Listing
April 2019
1 Read

Role of Oxidative Stress in Tuberculous Meningitis: a Clinico-Radiological Correlation.

J Mol Neurosci 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India.

Central nervous system infection may be associated with oxidative stress and may influence clinical severity and outcome. We report oxidative stress markers in the patients with tuberculous meningitis (TBM) and correlate these with clinico-radiological severity and outcome. Fifty-six patients with TBM diagnosed on the basis of clinical, cerebrospinal fluid (CSF), and magnetic resonance (MRI) were included. Read More

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http://link.springer.com/10.1007/s12031-019-01304-0
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http://dx.doi.org/10.1007/s12031-019-01304-0DOI Listing
April 2019
1 Read

Separate Gene Transfers into Pre- and Postsynaptic Neocortical Neurons Connected by mGluR5-Containing Synapses.

J Mol Neurosci 2019 Apr 10. Epub 2019 Apr 10.

Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, USA.

mGluR5-containing synapses have essential roles in synaptic plasticity, circuit physiology, and learning, and dysfunction at these synapses is implicated in specific neurological disorders. As mGluR5-containing synapses are embedded in large and complex distributed circuits containing many neuron and synapse types, it is challenging to elucidate the roles of these synapses and to develop treatments for the associated disorders. Thus, it would be advantageous to deliver different genes into pre- and postsynaptic neurons connected by a mGluR5-containing synapse. Read More

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http://dx.doi.org/10.1007/s12031-019-01317-9DOI Listing

The Association Between Neuropsychological Function with Serum Vitamins A, D, and E and hs-CRP Concentrations.

J Mol Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Vitamin status and the presence of subclinical inflammation may affect cognitive performance and behavior. We have investigated the relationship between serum fat soluble vitamins (vitamins A, D, and E) and inflammatory markers with aggression and cognitive abilities, in a population of healthy adolescents. A cross-sectional study of 940 adolescent girls was performed. Read More

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http://dx.doi.org/10.1007/s12031-019-01288-xDOI Listing
April 2019
4 Reads

Chronic Antipsychotic Treatment Modulates Aromatase (CYP19A1) Expression in the Male Rat Brain.

J Mol Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Department of Histology, School of Medicine in Katowice, Medical University of Silesia, ul. Medyków Street 18, 40-752, Katowice, Poland.

Antipsychotic drugs, known as the antagonists of dopaminergic receptors, may also affect a large spectrum of other molecular signaling pathways in the brain. Despite the numerous ongoing studies on neurosteroid action and regulation, there are no reports regarding the influence of extended treatment with typical and atypical neuroleptics on brain aromatase (CYP19A1) expression. In the present study, we assessed for the first time aromatase mRNA and protein levels in the brain of rats chronically (28 days) treated with olanzapine, clozapine, and haloperidol using quantitative real-time PCR, end-point RT-PCR, and Western blotting. Read More

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http://dx.doi.org/10.1007/s12031-019-01307-xDOI Listing

Dynamic Effects of Ioversol on the Permeability of the Blood-Brain Barrier and the Expression of ZO-1/Occludin in Rats.

J Mol Neurosci 2019 Apr 7. Epub 2019 Apr 7.

Department of Neurology, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, No.157 XiWuLu Street, Xi'an, 710004, Shaanxi, China.

Blood-brain barrier (BBB) dysfunction is involved in the pathogenesis of contrast-induced encephalopathy (CIE), which is a rare adverse event following angiography. In this study, we observed the dynamic effect and potential mechanism of ioversol on the BBB in rats. Eighty-one healthy rats were randomly divided into a normal control group (n = 9), ioversol group (n = 36), and 0. Read More

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http://dx.doi.org/10.1007/s12031-019-01305-zDOI Listing

Correction to: Investigation of Neuregulin-1 and Glial Cell-Derived Neurotrophic Factor in Rodent Astrocytes and Microglia.

J Mol Neurosci 2019 Apr 5. Epub 2019 Apr 5.

Clinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

The original version of this article unfortunately contained mistakes in the author group and affiliation sections. Author Markus H. Schwab's name was incorrectly presented as "H. Read More

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http://link.springer.com/10.1007/s12031-019-01315-x
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http://dx.doi.org/10.1007/s12031-019-01315-xDOI Listing
April 2019
1 Read

Type 2 Diabetes Mellitus Is Associated with the Risk of Cognitive Impairment: a Meta-Analysis.

J Mol Neurosci 2019 Apr 4. Epub 2019 Apr 4.

Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.

The present meta-analysis aimed to evaluate the interaction between type 2 diabetes mellitus (T2DM) and the risk of cognitive impairment. The studies that fulfilled certain inclusion criteria were selected from online databases including PubMed, Embase, and the Cochrane Library. Data extraction and quality assessment were conducted, and subgroup analysis was performed according to the study area, population sources, and types of cognitive impairment. Read More

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http://link.springer.com/10.1007/s12031-019-01290-3
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http://dx.doi.org/10.1007/s12031-019-01290-3DOI Listing
April 2019
3 Reads

The Neuroprotective Effect of miR-181a After Oxygen-Glucose Deprivation/Reperfusion and the Associated Mechanism.

J Mol Neurosci 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Hunan Provincial People's Hospital, Nanhua University, No.61 Jiefang west road, Changsha, 410005, Hunan, China.

The level of miR-181a decreases rapidly in N2a cells following oxygen-glucose deprivation/reperfusion, but its role in this process is unclear. Reelin, a regulator of neuronal migration and synaptogenesis, is a predicted target of miR-181a. We hypothesized that miR-181a reduces neuronal apoptosis and protects neurons by targeting reelin. Read More

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http://dx.doi.org/10.1007/s12031-019-01300-4DOI Listing

Animal Weight Is an Important Variable for Reliable Cuprizone-Induced Demyelination.

J Mol Neurosci 2019 Apr 2. Epub 2019 Apr 2.

Institute of Anatomy, Rostock University Medical Center, 18057, Rostock, Germany.

An elegant model to study mechanisms operant during oligodendrocyte degeneration and subsequent demyelination is the cuprizone model. In that model, mice are intoxicated with the copper chelation agent cuprizone which results in early oligodendrocyte stress, oligodendrocyte apoptosis, and, finally, demyelination. Here, we systematically investigated to what extent the animals' weight at the beginning of the cuprizone intoxication period is critical for the reproducibility of the cuprizone-induced pathology. Read More

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http://dx.doi.org/10.1007/s12031-019-01312-0DOI Listing

Application of Single-Nucleotide Polymorphisms in the Diagnosis of Autism Spectrum Disorders: A Preliminary Study with Artificial Neural Networks.

J Mol Neurosci 2019 Apr 1. Epub 2019 Apr 1.

Dental School, Shahid Beheshti University of Medical Science, Tehran, Iran.

Autism spectrum disorder (ASD) includes different neurodevelopmental disorders characterized by deficits in social communication, and restricted, repetitive patterns of behavior, interests or activities. Based on the importance of early diagnosis for effective therapeutic intervention, several strategies have been employed for detection of the disorder. The artificial neural network (ANN) as a type of machine learning method is a common strategy. Read More

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http://dx.doi.org/10.1007/s12031-019-01311-1DOI Listing

Prognostic Role of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Isocitrate Dehydrogenase-Mutant Glioma with 1p19q Co-Deletion.

J Mol Neurosci 2019 Mar 30. Epub 2019 Mar 30.

School of Clinical Medicine and Department of Neurosurgery, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Background: Chicken ovalbumin upstream promoter transcription factor II is known to play a crucial role in the tumor microenvironment. However, the role of NR2F2 in gliomas is unknown.

Methods: The genomic and clinical data of 530 cases of lower grade gliomas (LGGs) patients and 167 cases of glioblastoma (GBM) patients in The Cancer Genome Atlas (TCGA) were extracted for analysis. Read More

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http://dx.doi.org/10.1007/s12031-019-01281-4DOI Listing
March 2019
5 Reads

Euxanthone Ameliorates Sevoflurane-Induced Neurotoxicity in Neonatal Mice.

J Mol Neurosci 2019 Mar 30. Epub 2019 Mar 30.

Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 JingWu Road, Jinan, 250021, China.

Sevoflurane is a widely used anesthetic. A series of recent studies have shown that exposure to sevoflurane at an early stage is a risk factor for the development of learning and memory dysfunction. Euxanthone is a xanthone derivative obtained from Polygala caudata. Read More

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http://link.springer.com/10.1007/s12031-019-01303-1
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http://dx.doi.org/10.1007/s12031-019-01303-1DOI Listing
March 2019
4 Reads

Apparent Correlations Between AMPK Expression and Brain Inflammatory Response and Neurological Function Factors in Rats with Chronic Renal Failure.

J Mol Neurosci 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurosurgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglin Xia Road, Yuexiu District, Guangzhou, 510080, Guangdong Province, China.

To explore the correlations between AMP-activated protein kinase (AMPK) expression and brain inflammatory response and neurological function factors in rats with chronic renal failure. Chronic renal failure models in rats were established, and the healthy control group (normal group) was set. Chronic renal failure model rats were divided into model group (without any treatment), control group (intraperitoneal injection of normal saline), A-769662 group (intraperitoneal injection of AMPK specific activator), and compound C group (intraperitoneal injection of AMPK specific inhibitor). Read More

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http://dx.doi.org/10.1007/s12031-019-01299-8DOI Listing

Inhibition of MSK1 Promotes Inflammation and Apoptosis and Inhibits Functional Recovery After Spinal Cord Injury.

J Mol Neurosci 2019 Mar 27. Epub 2019 Mar 27.

Department of Spine Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Mitogen- and stress-activated kinase (MSK) 1 is a nuclear serine/threonine kinase. In the central nervous system, it plays an important role in regulating cell proliferation and neuronal survival; it is also involved in astrocyte inflammation and the inhibition of inflammatory cytokine production. However, its specific role in spinal cord injury is not clear. Read More

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http://dx.doi.org/10.1007/s12031-019-01298-9DOI Listing

A Compound Heterozygote for GCH1 Mutation Represents a Case of Atypical Dopa-Responsive Dystonia.

J Mol Neurosci 2019 Mar 25. Epub 2019 Mar 25.

S. N. Pradhan Centre for Neurosciences, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, India.

Dopa-responsive dystonia (DRD), a movement disorder, is characterized by young onset dystonia and dramatic response to levodopa treatment. However, the wide range of phenotypic spectrum of the disease often leads to misdiagnosis. DRD is usually caused by mutation in GCH1 gene coding for GTP cyclohydrolase 1 (GTPCH1) enzyme, which is involved in biosynthesis of tetrahydrobiopterin (BH4) and dopamine. Read More

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http://link.springer.com/10.1007/s12031-019-01301-3
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http://dx.doi.org/10.1007/s12031-019-01301-3DOI Listing
March 2019
4 Reads

A Causal Relationship in Spinal Cord Injury Rat Model Between Microglia Activation and EGFR/MAPK Detected by Overexpression of MicroRNA-325-3p.

J Mol Neurosci 2019 Mar 25. Epub 2019 Mar 25.

Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Erqi District, Zhengzhou, 450003, Henan Province, China.

Microglial activation and inflammatory response played an important role in the secondary injury of spinal cord injury (SCI). Several microRNAs were associated with this procedure, but the underlying molecular mechanism was poorly understood. Sprague-Dawley (SD) rats were divided into four groups: SCI group (n = 7), agomiR-325-3p group (n = 7), and their control groups. Read More

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http://dx.doi.org/10.1007/s12031-019-01297-wDOI Listing

Rab7b Overexpression-Ameliorated Ischemic Brain Damage Following tMCAO Involves Suppression of TLR4 and NF-κB p65.

J Mol Neurosci 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurology, Tianjin Baodi Hospital, No.8 of Guang Chuan Road, Baodi District, Tianjin, 301800, China.

Cerebral stroke is one of the leading causes of death and permanent disability worldwide. Toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) p65 play a critical role in brain damage following ischemia-induced stroke. Rab7b, a lysosome-associated small Rab GTPase, has been implicated in TLR4 regulation; however, its role in cerebral stroke is poorly understood. Read More

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http://dx.doi.org/10.1007/s12031-019-01295-yDOI Listing
March 2019
1 Read

Tuftelin Is Required for NGF-Induced Differentiation of PC12 Cells.

J Mol Neurosci 2019 May 21;68(1):135-143. Epub 2019 Mar 21.

School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Nerve growth factor (NGF) promotes pleiotropic gene transcription-dependent biological effects, in neuronal and non-neuronal cells, including survival, proliferation, differentiation, neuroprotection, pain, and angiogenesis. It is hypothesized that during odontogenesis, NGF may be implicated in morphogenetic and mineralization events by affecting proliferation and/or differentiation of dental cells. Tuftelin belongs to the enamel associated teeth proteins and is thought to play a role in enamel mineralization. Read More

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http://dx.doi.org/10.1007/s12031-019-01292-1DOI Listing

Expression Profile of Selected MicroRNAs in the Peripheral Blood of Multiple Sclerosis Patients: a Multivariate Statistical Analysis with ROC Curve to Find New Biomarkers for Fingolimod.

J Mol Neurosci 2019 May 21;68(1):153-161. Epub 2019 Mar 21.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Multiple sclerosis (MS) as a chronic autoimmune disease of the central nervous system (CNS) has been associated with dysregulation of several genes including miRNAs. In the present study, we assessed transcript levels of seven miRNAs (miR-96-5p, miR-211-5p, miR-15a, miR-34a-5p, miR-204-5p, miR-501-5p, and miR-524-5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. Expression levels of miR-211-5p and miR-34a-5p were significantly decreased in MS patients compared with healthy subjects (P values of 0. Read More

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http://dx.doi.org/10.1007/s12031-019-01294-zDOI Listing
May 2019
4 Reads

Neuroprotective Influence of miR-301a Inhibition in Experimental Cerebral Ischemia/Reperfusion Rat Models Through Targeting NDRG2.

J Mol Neurosci 2019 May 20;68(1):144-152. Epub 2019 Mar 20.

Department of Nursing, Shanxian Central Hospital, No. 1 Wenhua Road, Shanxian, 274300, Shandong, China.

The objective of this study is to find out the potential influence of miR-301a in an experimental cerebral ischemia-reperfusion (I/R) rat model through targeting NDRG2. Rats with cerebral I/R injury were constructed and classified into model, miR-301a inhibitor, miR-301a mimic, NC (negative control), siNDRG2, NDRG2, and miR-301a inhibitor + si-NDRG2 groups, as well as another sham group. Cerebral infarct volume and cell apoptosis were observed by TTC staining and TUNEL staining. Read More

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http://dx.doi.org/10.1007/s12031-019-01293-0DOI Listing

Activation of the Oxytocin Receptor Modulates the Expression of Synaptic Adhesion Molecules in a Cell-Specific Manner.

J Mol Neurosci 2019 Mar 19. Epub 2019 Mar 19.

Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovakia.

Synaptic cell adhesion molecules, including neurexins and neuroligins, mediate the formation and maintenance of connections between neuronal cells. Although neurexins and neuroligins are known to interact with each other in a calcium-dependent manner and several neuropeptides have been shown to act through G protein-coupled receptors to increase intracellular calcium levels, no studies have examined the role of the neuropeptide oxytocin in association with adhesion molecules. Given that oxytocin receptors are located on presynaptic and postsynaptic membranes and that oxytocin exerts direct effects on neuronal excitability, it could be hypothesized that oxytocin affects the expression of cell surface adhesion molecules. Read More

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http://dx.doi.org/10.1007/s12031-019-01296-xDOI Listing
March 2019
2 Reads

Combined Inhibition of HDAC and EGFR Reduces Viability and Proliferation and Enhances STAT3 mRNA Expression in Glioblastoma Cells.

J Mol Neurosci 2019 May 18;68(1):49-57. Epub 2019 Mar 18.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil.

Changes in expression of histone deacetylases (HDACs), which epigenetically regulate chromatin structure, and mutations and amplifications of the EGFR gene, which codes for the epidermal growth factor receptor (EGFR), have been reported in glioblastoma (GBM), the most common and malignant type of brain tumor. There are likely interplays between HDACs and EGFR in promoting GBM progression, and HDAC inhibition can cooperate with EGFR blockade in reducing the growth of lung cancer cells. Here, we found that either HDAC or EGFR inhibitors dose-dependently reduced the viability of U87 and A-172 human GBM cells. Read More

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http://link.springer.com/10.1007/s12031-019-01280-5
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http://dx.doi.org/10.1007/s12031-019-01280-5DOI Listing
May 2019
9 Reads

Somatostatin-Mediated Changes in Microtubule-Associated Proteins and Retinoic Acid-Induced Neurite Outgrowth in SH-SY5Y Cells.

J Mol Neurosci 2019 May 16;68(1):120-134. Epub 2019 Mar 16.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Somatostatin (SST) is a growth hormone inhibitory peptide involved in regulation of several physiological responses of cells including neurotransmission, cell migration, maturation, and neurite formation. In the present study, we examined the role of SST in all-trans retinoic acid (RA)-induced progression of neurite outgrowth in SH-SY5Y cells. We also determined the morphological and developmental changes in prominent intracellular markers of neurite growth including microtubule-associated protein 2 (MAP2), neuron-specific III β-tubulin (TUJ1), and Tau. Read More

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http://dx.doi.org/10.1007/s12031-019-01291-2DOI Listing

Insights into the Potential Role of Mercury in Alzheimer's Disease.

J Mol Neurosci 2019 Apr 15;67(4):511-533. Epub 2019 Mar 15.

Research Department, Innlandet Hospital Trust, Brumunddal, Norway.

Mercury (Hg), which is a non-essential element, is considered a highly toxic pollutant for biological systems even when present at trace levels. Elevated Hg exposure with the growing release of atmospheric pollutant Hg and rising accumulations of mono-methylmercury (highly neurotoxic) in seafood products have increased its toxic potential for humans. This review aims to highlight the potential relationship between Hg exposure and Alzheimer's disease (AD), based on the existing literature in the field. Read More

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http://dx.doi.org/10.1007/s12031-019-01274-3DOI Listing
April 2019
1 Read
2.343 Impact Factor

MicroRNA-211-5p Enhances Analgesic Effect of Dexmedetomidine on Inflammatory Visceral Pain in Rats by Suppressing ERK Signaling.

J Mol Neurosci 2019 May 14;68(1):19-28. Epub 2019 Mar 14.

Department of Anesthesiology, Affiliated Huxi Hospital of Jining Medical College, Shanxian Central Hospital, No.1, Wenhua Road, Shanxian County, Heze, 274300, Shandong, China.

Dexmedetomidine (DEX) is a high-selectivity α2 adrenergic receptor agonist. The present study aimed to characterize the analgesic effects of DEX on TNBS-induced chronic inflammatory visceral pain (CIVP) in rats and to evaluate whether its antinociceptive effect is regulated by microRNAs (miRNAs) and the ERK pathway. TNBS with or without DEX was administered to 60 male Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1007/s12031-019-01278-zDOI Listing

Secretin Prevents Apoptosis in the Developing Cerebellum Through Bcl-2 and Bcl-xL.

J Mol Neurosci 2019 Mar 14. Epub 2019 Mar 14.

School of Biological Sciences, The University of Hong Kong, Hong Kong, SAR, Hong Kong.

Secretin (SCT) is involved in a variety of physiological processes and has been implicated in preventing apoptosis during brain development. However, little is known about the molecular mechanism underlying its neuroprotective effects. The B cell lymphoma 2 (Bcl-2) family proteins, such as Bcl-2 and Bcl-xL, determine the commitment of neurons to apoptosis. Read More

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http://dx.doi.org/10.1007/s12031-019-01287-yDOI Listing
March 2019
3 Reads

Pharmacological Manipulation of Trk, p75NTR, and NGF Balance Restores Memory Deficit in Global Ischemia/Reperfusion Model in Rats.

J Mol Neurosci 2019 May 12;68(1):78-90. Epub 2019 Mar 12.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El Aini st., Cairo, 11562, Egypt.

Long-term memory impairment is reported in more than 50% of cardiac arrest survivors. Monosialoganglioside (GM1) provided neuroprotection in experimental models of stroke but failed to replicate its promise clinically for unknown reasons. GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk). Read More

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http://dx.doi.org/10.1007/s12031-019-01284-1DOI Listing

Cascade Signals of Papaverine Inhibiting LPS-Induced Retinal Microglial Activation.

Authors:
Ting Zhou Yu Zhu

J Mol Neurosci 2019 May 9;68(1):111-119. Epub 2019 Mar 9.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, East Jianshe Road, Zhengzhou, 450001, People's Republic of China.

Studies have shown that papaverine can inhibit lipopolysaccharide (LPS)-induced microglial activation. The retinal primary microglia of newborn SD rats were isolated and purified, and a LPS-induced microglia activation model was established. The protein phosphorylation level of the signaling pathway was detected by western blotting. Read More

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http://dx.doi.org/10.1007/s12031-019-01289-wDOI Listing

Glucocorticoid Receptor Stimulation Resulting from Early Life Stress Affects Expression of DNA Methyltransferases in Rat Prefrontal Cortex.

J Mol Neurosci 2019 May 9;68(1):99-110. Epub 2019 Mar 9.

Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411, Tartu, Estonia.

Early life stress initiates long-term neurobiological changes that affect stress resilience and increased susceptibility to psychopathology. Maternal separation (MS) is used to cause early life stress and it induces profound neurochemical and behavioral changes that last until adulthood. The molecular pathways of how MS affects the regulation of DNA methyltransferases (Dnmt) in brain have not been entirely characterized. Read More

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http://dx.doi.org/10.1007/s12031-019-01286-zDOI Listing

Smad Anchor for Receptor Activation and Phospho-Smad3 Were Upregulated in Patients with Temporal Lobe Epilepsy.

J Mol Neurosci 2019 May 7;68(1):91-98. Epub 2019 Mar 7.

Institute of Neuroscience, Department of Human Anatomy, Chongqing Medical University, No.1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.

Smad anchor for receptor activation (SARA) is an important regulator of transforming growth factor β (TGF-β) signaling by recruiting Smad2/3 to TGF-β receptors. We recently demonstrated that the expressions of SARA and level of downstream phospho-Smad3 (p-Smad3) were upregulated in the brain in the epileptic rat model, but were never examined in patients with temporal lobe epilepsy (TLE). In this study, we examined the expressions of SARA and level of p-Smad3 in brain tissues of TLE patients using immunohistochemistry and western blot to demonstrate that SARA activation in neurons is sufficient to facilitate TGF- β pathway in patients to regulate epilepsy. Read More

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http://link.springer.com/10.1007/s12031-019-01285-0
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http://dx.doi.org/10.1007/s12031-019-01285-0DOI Listing
May 2019
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Limb Remote Ischemic Preconditioning Reduces Repeated Ketamine Exposure-Induced Adverse Effects in the Developing Brain of Rats.

J Mol Neurosci 2019 May 7;68(1):58-65. Epub 2019 Mar 7.

Department of Anaesthesiology, General Hospital of Ningxia Medical University, Shengli Street, Yinchuan, 750004, NingXia, China.

Prolonged or repeated exposure to ketamine, a common anesthetic in pediatrics, has been shown to induce neurotoxicity and long-term neurocognitive deficits in the developing brain. Therefore, identification of potential therapeutic targets for preventing or alleviating such neurodegeneration and neuroapoptosis induced by ketamine is urgently needed. Remote ischemic preconditioning of the limb provides neuroprotection in different models of cerebral injury. Read More

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http://dx.doi.org/10.1007/s12031-019-01282-3DOI Listing
May 2019
7 Reads

Angiogenic Gene Profiles in Laser-Microdissected Microvessels and Neurons from Ischemic Penumbra of Rat Brain.

J Mol Neurosci 2019 Apr 6;67(4):643-653. Epub 2019 Mar 6.

Institute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.

Angiogenesis is induced immediately after cerebral ischemia and plays a pivotal role in the strategy against ischemic injury. We hypothesized that the coordinated interaction between microvessels and neurons was altered immediately after stroke, and microvessels and neurons would show the temporal specificity of angiogenic gene profiles after cerebral ischemia. Microvessels and neurons were harvested in the ischemic penumbra of rat brain using the PixCell II laser capture microdissection (LCM) instrument. Read More

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http://dx.doi.org/10.1007/s12031-019-01270-7DOI Listing
April 2019
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2.343 Impact Factor

PAX3 Promotes Proliferation of Human Glioma Cells by WNT/β-Catenin Signaling Pathways.

J Mol Neurosci 2019 May 2;68(1):66-77. Epub 2019 Mar 2.

Department of Neurosurgery, Zhejiang Cancer Hospital, 1 Ban Shan east road, Hangzhou, 310022, Zhejiang Province, China.

The PAX3 (paired box 3) gene plays an important role in embryonic development, diseases, and cancer formation. Our preliminary studies have shown that PAX3 gene is upregulated in glioma cells, which is associated with a worse prognosis. Moreover, PAX3, by facilitating cell proliferation and invasion and inhibiting cell apoptosis, plays an oncogenic role in glioma. Read More

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http://link.springer.com/10.1007/s12031-019-01283-2
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http://dx.doi.org/10.1007/s12031-019-01283-2DOI Listing
May 2019
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Ghrelin Promotes Cortical Neurites Growth in Late Stage After Oxygen-Glucose Deprivation/Reperfusion Injury.

J Mol Neurosci 2019 May 26;68(1):29-37. Epub 2019 Feb 26.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, People's Republic of China.

Acyl ghrelin, a novel brain-gut peptide, is an endogenous ligand for the growth hormone secretagogue receptor. Accumulated research data have shown that acyl ghrelin exercises a significant neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury in animal models and in cultured neurons during the acute phase, usually, 1 day after cerebral ischemia. The chronic effects of acyl ghrelin 1 week after brain ischemia remain largely unknown. Read More

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http://dx.doi.org/10.1007/s12031-019-01279-yDOI Listing
May 2019
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2.343 Impact Factor

The Neuroprotective Effect of Histamine H4 Receptor Antagonist on Dopaminergic Neurons in Parkinson's Disease.

J Mol Neurosci 2019 Feb 23. Epub 2019 Feb 23.

Department of Neurology, Shenzhen People's Hospital, Jinan University, Shenzhen, China.

This research was aimed to explore the neuroprotective effects of histamine H3 and H4 receptor antagonists on dopaminergic (DA) neurons in Parkinson's disease (PD) model rats induced by 6-hydroxydopamine (6-OHDA) and their mechanism. The changes of the level of monoamine neurotransmitters, the number and morphology of TH-positive cells, and inflammatory factors in the striatum were used to evaluate the protective effects of H3 and H4 receptor antagonists on PD rats. The effects of histamine H4 receptor antagonist on the activation of microglial cell in PD rat and cells of PD model were observed, further exploring the mechanism of H4 receptor antagonist in improving the damage of PD rats. Read More

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http://dx.doi.org/10.1007/s12031-018-1242-8DOI Listing
February 2019

NF1 Somatic Mutation in Dystrophic Scoliosis.

J Mol Neurosci 2019 May 18;68(1):11-18. Epub 2019 Feb 18.

Department of Pediatrics, Division of Medical Genetics, Stanford University, 300 Pasteur Dr., H315, Stanford, CA, 94305, USA.

Scoliosis is a common manifestation of neurofibromatosis type 1, causing significant morbidity. The etiology of dystrophic scoliosis in neurofibromatosis type 1 is not fully understood and therapies are lacking. Somatic mutations in NF1 have been shown in tibial pseudarthrosis providing rationale for similar processes in neurofibromatosis type 1-associated dystrophic scoliosis. Read More

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http://dx.doi.org/10.1007/s12031-019-01277-0DOI Listing
May 2019
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Current and Potential Approaches for Defining Disease Signatures: a Systematic Review.

J Mol Neurosci 2019 Apr 18;67(4):550-558. Epub 2019 Feb 18.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Identifying disease signatures in order to facilitate accurate diagnosis/treatment has been the focus of research efforts in the last decade. However, the term "disease signature" has not been properly defined, resulting in inconsistencies between studies, as well as limited ability to fully utilize the tools/information available in the evolving field of healthcare big data. Research was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines. Read More

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http://dx.doi.org/10.1007/s12031-019-01269-0DOI Listing

Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children.

J Mol Neurosci 2019 May 18;68(1):1-10. Epub 2019 Feb 18.

Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.

More than 25% of the world's population is affected by anemia, of which more than 50% suffers from iron deficiency anemia (IDA). Children below 7 years of age are the population group that is most vulnerable to iron deficiency. Iron is an essential element in brain metabolism. Read More

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http://dx.doi.org/10.1007/s12031-019-01276-1DOI Listing
May 2019
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LATS2 Inhibits Malignant Behaviors of Glioma Cells via Inactivating YAP.

J Mol Neurosci 2019 May 15;68(1):38-48. Epub 2019 Feb 15.

Institute of Nervous System Diseases, Xuzhou Medical University, 84 West Huai-hai Road, Xuzhou, 221002, Jiangsu, People's Republic of China.

We previously reported that LATS2, the upstream serine/threonine kinase of Yes-associated protein (YAP), is downregulated in gliomas and exhibits negative correlation with the prognosis of glioma patients. In this work, we aimed to explore the role and mechanism of large tumor suppressor kinase (LATS2) in the progression of malignant gliomas. We found that over-expression of LATS2 inhibited glioma cell proliferation and migration/invasion, while LATS2 downregulation promoted them. Read More

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http://dx.doi.org/10.1007/s12031-019-1262-zDOI Listing
May 2019
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Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome.

J Mol Neurosci 2019 Apr 13;67(4):632-642. Epub 2019 Feb 13.

Genetics & Regenerative Medicine Research Centre (GRMRC), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Notch signalling pathway is involved in the proliferation of neural progenitor cells (NPCs), to inhibit neuronal cell commitment and to promote glial cell fate. Notch protein is cleaved by gamma-secretase, a multisubunit transmembrane protein complex that releases the Notch intracellular domain (NICD) and subsequently activates the downstream targets. Down syndrome (DS) individuals exhibit an increased number of glial cells (particularly astrocytes), and reduced number of neurons suggesting the involvement of Notch signalling pathway in the neurogenic-to-gliogenic shift in DS brain. Read More

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http://dx.doi.org/10.1007/s12031-019-01275-2DOI Listing
April 2019
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Curcumin Alleviates β Amyloid-Induced Neurotoxicity in HT22 Cells via Upregulating SOD2.

J Mol Neurosci 2019 Apr 12;67(4):540-549. Epub 2019 Feb 12.

Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, China.

Curcumin protects neuronal cells exposed to β amyloid (Aβ); the mechanism, however, is still obscure. The aim of this study is to determine whether the type 2 superoxide dismutase (SOD2) mediates curcumin-induced protective effects in Aβ-treated neuronal cells. In this study, the HT22 neuronal cells were exposed to Aβ to imitate neuronal injury in Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1007/s12031-019-01267-2DOI Listing
April 2019
2.343 Impact Factor

Dietary Energy Restriction Ameliorates Cognitive Impairment in a Mouse Model of Traumatic Brain Injury.

J Mol Neurosci 2019 Apr 8;67(4):613-621. Epub 2019 Feb 8.

Department of Anatomy and Anthropology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Traumatic brain injury (TBI) is one of the most common causes of neurological damage in young people. It was previously reported that dietary restriction, by either intermittent fasting (IF) or daily caloric restriction (CR), could protect neurons against dysfunction and degeneration in animal models of stroke and Parkinson's disease. Recently, several studies have shown that the protein Sirtuin 1 (SIRT1) plays a significant role in the induced neuroprotection following dietary restriction. Read More

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http://dx.doi.org/10.1007/s12031-019-01271-6DOI Listing
April 2019
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Treatment with MQA, a Derivative of Caffeoylquinic Acid, Provides Neuroprotective Effects against Cerebral Ischemia Through Suppression of the p38 Pathway and Oxidative Stress in Rats.

J Mol Neurosci 2019 Apr 8;67(4):604-612. Epub 2019 Feb 8.

School of Pharmacy, Ministry of Education, Shihezi University/Key Laboratory of Xingjiang Phytomedicine Resources Utilization, Shihezi, China.

1,5-O-dicaffeoyl-3-O-(4-malic acid methylester)-quinic acid (MQA), extracted from Arctium lappa L., has been observed to exert neuroprotective effects in vitro. The aim of this study was to investigate whether MQA is an effective therapeutic method for cerebral ischemic injury in vivo. Read More

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http://dx.doi.org/10.1007/s12031-019-01268-1DOI Listing
April 2019
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Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway.

Authors:
Ruisi Tian Shu Wang

J Mol Neurosci 2019 Mar 6;67(3):456-466. Epub 2019 Feb 6.

Institute of Acupuncture and Moxibustion, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No.314 West Anshan Road, Nankai District, 300193, Tianjin, China.

This study is designed to explore the effect of electric acupuncture on the apoptosis of hippocampal neurons through the Notch3 signaling pathway. A middle cerebral artery occlusion (MCAO) mouse model was generated by thread embolization. A Y-maze was used to test cognitive function (learning and memory). Read More

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http://dx.doi.org/10.1007/s12031-018-1253-5DOI Listing
March 2019
1 Read