2,202 results match your criteria Journal of medical primatology[Journal]


An assay of drug-induced emesis in the squirrel monkey (Saimiri sciureus).

J Med Primatol 2019 Apr 10. Epub 2019 Apr 10.

Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts.

Background: Emesis has significant evolutionary value as a defense mechanism against ingested toxins; however, it is also one of the most common adverse symptoms associated with both disease and medical treatments of disease. The development of improved antiemetic pharmacotherapies has been impeded by a shortage of animal models.

Methods: The present studies characterized the responses of the squirrel monkey to pharmacologically diverse emetic drugs. Read More

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http://dx.doi.org/10.1111/jmp.12411DOI Listing
April 2019
1 Read

Laparoscopic repair of an umbilical hernia in a Western chimpanzee (Pan troglodytes verus) rescued in Sierra Leone.

J Med Primatol 2019 Apr 3. Epub 2019 Apr 3.

Wildlife Surgery International, Roslin, UK.

Laparoscopic umbilical hernia repair was performed in an adult female Western chimpanzee (Pan troglodytes verus) in a rescue centre in Sierra Leone. Biological mesh and laparoscopic spiral tacks via three 5 mm laparoscopy ports were used to close a 4 cm hernia. The chimpanzee recovered quickly and the hernia did not recur. Read More

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http://dx.doi.org/10.1111/jmp.12409DOI Listing

Adverse event following live attenuated chikungunya vaccine in a cynomolgus macaque with pre-existing chronic hydrocephalus.

J Med Primatol 2019 Apr 3. Epub 2019 Apr 3.

Tulane National Primate Research Center, Covington, Louisiana.

A cynomolgus macaque (Macaca fascicularis) with a pre-existing, undiagnosed, subclinical but severe cerebral hydrocephalus was enrolled in a study of long-term immunogenicity of the IRES/CHIK vaccine. The animal began showing signs of neurological dysfunction post-vaccination, which progressed and ultimately resulted in euthanasia. The underlying brain abnormality was revealed at necropsy and was subsequently investigated with gross and microscopic examination. Read More

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http://dx.doi.org/10.1111/jmp.12414DOI Listing

Facial dysplasia in wild forest olive baboons (Papio anubis) in Sebitoli, Kibale National Park, Uganda: Use of camera traps to detect health defects.

J Med Primatol 2019 Apr 2. Epub 2019 Apr 2.

UMR 7206 CNRS/MNHN/P7, Eco-anthropologie, Hommes, et Environnements, Musée de l'Homme, Museum national d'Histoire naturelle, Paris, France.

Background: Primate populations are in decline, mainly affected by agriculture leading to habitat loss, fragmentation but also chemical pollution. Kibale National Park (Uganda), Sebitoli forest, surrounded by tea and crop fields, is the home range of chimpanzees presenting congenital facial dysplasia. This study aimed to identify to what extent the same phenotypical features are observed in baboons (Papio anubis) of this area. Read More

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http://dx.doi.org/10.1111/jmp.12408DOI Listing

Salivary gland neoplasms in non-human primates: A case series and brief literature review.

J Med Primatol 2019 Apr 2. Epub 2019 Apr 2.

Southwest National Primate Research Center at the Texas Biomedical Research Institute, San Antonio, Texas.

Background: Salivary gland neoplasms are rare in non-human primates.

Methods: Thirty-five years of pathology records were reviewed at the Southwest (SNPRC) and Yerkes (YNPRC) National Primate Research Centers. An in-depth literature search for salivary gland neoplasms in non-human primates was performed. Read More

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http://dx.doi.org/10.1111/jmp.12412DOI Listing
April 2019
1 Read

Cutaneous epitheliotropic lymphoma in a baboon (Papio spp.): A case report and a brief literature review.

J Med Primatol 2019 Apr 2. Epub 2019 Apr 2.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.

Cutaneous epitheliotropic lymphoma (CEL) has not been reported in non-human primates. We report the first case of CEL in a 9-year-old baboon. The phenotype of the neoplastic cells in this baboon is similar to CEL in humans (CD3+, CD4+, CD8-) and different from dogs (CD3+, CD4-, CD8+). Read More

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http://dx.doi.org/10.1111/jmp.12410DOI Listing
April 2019
1 Read

In situ hybridization assay for the diagnosis of chagas myocarditis and orchitis in a rhesus macaque (Macaca mulatta): A case report.

J Med Primatol 2019 Mar 25. Epub 2019 Mar 25.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.

We present the first documented case of Trypanosoma cruzi-induced orchitis in a rhesus macaque. Additionally, we describe an in situ hybridization-based assay to confirm T. cruzi infection in formalin-fixed tissues. Read More

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http://dx.doi.org/10.1111/jmp.12406DOI Listing
March 2019
2 Reads

Complete rectal prolapse in wild anubis baboons (Papio anubis).

J Med Primatol 2019 Mar 24. Epub 2019 Mar 24.

Mpala Research Centre, Nanyuki, Kenya.

This report describes two cases of rectal prolapse in wild anubis baboons (Papio anubis), with one spontaneous resolution. Both occurred after individuals consumed low-water, high-fibre dried maize during provisioning prior to capture, while one also experienced distress during capture. Read More

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http://dx.doi.org/10.1111/jmp.12405DOI Listing

Molecular suitability of the chacma baboon in human-targeted Von Willebrand factor directed studies.

J Med Primatol 2019 Mar 20. Epub 2019 Mar 20.

Human Molecular Biology Unit, Faculty of Health Sciences, School of Biomedical Sciences, University of the Free State, Bloemfontein, South Africa.

Background: Von Willebrand factor (VWF) has a central role in primary haemostasis and is a popular pharmaceutical target in the prevention and treatment of disorders such as acute coronary syndrome and thrombotic thrombocytopenic purpura. We have evaluated numerous possible treatments targeting VWF in the chacma baboon. Unfortunately, no data exist regarding the molecular similarity of the chacma baboon and human VWF protein, resulting in limited translatability of results. Read More

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http://dx.doi.org/10.1111/jmp.12407DOI Listing
March 2019
1 Read

Electrocardiographic parameters of Sapajus libidinosus (SPIX, 1823) after chemical immobilization with tiletamine-zolazepam.

J Med Primatol 2019 Mar 13. Epub 2019 Mar 13.

Programa de Pós-Graduação em Medicina Veterinária, Centro de Saúde e Tecnologia Rural, Universidade Federal de Campina Grande, Patos, Paraíba, Brasil.

Background: Tiletamine-zolazepam is a widely used as an alternative chemical immobilization method in non-human primates, with a safe application pathway and necessary relaxation. In order to determine the electrocardiographic parameters of Sapajus libidinosus after intramuscular tiletamine-zolazepam administration at the dose of 5 mg/kg, nine animals were submitted to anesthesia.

Methods: The interpretation of the electrocardiogram determined: heart rate in bpm and heart rhythm, P wave, P-R interval, R wave, QRS complex, T wave, Q-T interval, corrected QT interval and electrical axis. Read More

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http://dx.doi.org/10.1111/jmp.12403DOI Listing
March 2019
4 Reads

Successful implementation of intestinal endoscopy in non-human primates prompts the possibility of achieving AIDS longitudinal intestinal research.

J Med Primatol 2019 Mar 7. Epub 2019 Mar 7.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, the National Kunming High Level Biosafety Research Center for Nonhuman Primate, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

HIV infection induces pathological changes in the intestinal mucosa. Here, a successful endoscopy was performed on the colon of a Chinese rhesus macaque by using Olympus CV170 gastroscope. The stability on postoperative recovery and the integrity of biopsy tissue implied a possibility of achieving AIDS longitudinal intestinal research on macaques. Read More

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http://doi.wiley.com/10.1111/jmp.12404
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http://dx.doi.org/10.1111/jmp.12404DOI Listing
March 2019
12 Reads

Ultrasonographic appearance and measurement of abdominal structures in healthy Capuchin monkeys (Sapajus spp.).

J Med Primatol 2019 Feb 19. Epub 2019 Feb 19.

Departement of Veterinary Medicine, University of Perugia, Perugia, Italy.

Background: Previous ultrasonographic studies of Sapajus apella to determine the normal anatomy and physiology are incomplete. The aim of this study was to determine normal ultrasonographic appearance and measurements of all abdominal organs and structures of interest.

Methods: Twelve adult monkeys were recruited considered healthy on the basis of history, physical examination, and general blood work. Read More

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http://dx.doi.org/10.1111/jmp.12402DOI Listing
February 2019
1 Read

Candida albicans-associated sepsis in a pre-term neonatal rhesus macaque (Macaca mulatta).

J Med Primatol 2019 Feb 8. Epub 2019 Feb 8.

Oregon National Primate Research Center, Division of Comparative Medicine, Oregon Health & Science University, Portland, Oregon.

Invasive Candida infections (ICI) have been associated with neurodevelopmental impairment or death in human pre-term neonates. Candidiasis in nonhuman primates is seen mostly in immunosuppressed animals, and ICI is not commonly reported. Here, we report a case of Candida albicans-associated ICI in a pre-term neonatal rhesus macaque. Read More

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http://doi.wiley.com/10.1111/jmp.12401
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http://dx.doi.org/10.1111/jmp.12401DOI Listing
February 2019
14 Reads

Nonketotic hyperglycinemia in captive-bred Vervet monkeys (Chlorocebus aethiops) with cataracts.

J Med Primatol 2019 Feb 6. Epub 2019 Feb 6.

Primate Unit and Delft Animal Centre (PUDAC), South African Medical Research Council, Cape Town, South Africa.

Background: Nonketotic hyperglycinemia (NKH) is a rare metabolic disorder that is characterized by high levels of glycine in plasma and cerebrospinal fluid in humans. In this study, total congenital cataract captive-bred Vervet monkeys (Chlorocebus aethiops) that are hyperglycinemic were screened to identify mutations in Bola type 3 (BOLA3), glutaredoxin 5 (GLRX5), and lipoate synthase (LIAS) genes.

Methods: Twenty-four Vervet monkeys (12 hyperglycinemic and 12 healthy controls) were selected for mutation analysis using polymerase chain reaction (PCR), Sanger sequencing, and reverse transcriptase-polymerase chain reaction (RT-PCR). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12400
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http://dx.doi.org/10.1111/jmp.12400DOI Listing
February 2019
8 Reads

CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques.

J Med Primatol 2019 Apr 5;48(2):82-89. Epub 2019 Feb 5.

Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: Tuberculosis (TB) kills millions of people every year. CD4 and CD8 T cells are critical in the immune response against TB. T cells expressing both CD4 and CD8 (CD4CD8 T cells) are functionally active and have not been examined in the context of TB. Read More

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http://dx.doi.org/10.1111/jmp.12399DOI Listing
April 2019
5 Reads

Subcutaneous thermal sensor microchip validation in vervet monkeys (Chlorocebus pygerythrus) during normothermic and hypothermic situations.

J Med Primatol 2019 Apr 24;48(2):77-81. Epub 2019 Jan 24.

Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, Alfara del Patriarca, Valencia, Spain.

Background: Internal temperature data are essential for clinical evaluation in veterinary medicine. During the last decade, new thermometry devices have been developed. Identification microchips with a temperature sensor offer double utility to clinicians by satisfying animal identification regulations and providing a non-invasive method for temperature measurement. Read More

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http://dx.doi.org/10.1111/jmp.12398DOI Listing
April 2019
2 Reads

Doppler and oscillometric mean blood pressure best represent direct blood pressure measurements in anesthetized rhesus macaques (Macaca mulatta).

J Med Primatol 2019 Apr 14;48(2):123-128. Epub 2019 Jan 14.

Department of Comparative Medicine, Stanford University, Stanford, California.

Background: Indirect blood pressure measurements are often used to guide clinical decisions, but few studies have verified their agreement with direct arterial blood pressure in nonhuman primates. Here, the accuracy and precision of Doppler (DOP) and oscillometric (OS) [systolic (OSsys), mean (OSmean), and diastolic (OSdias)] blood pressure readings were assessed in rhesus macaques.

Methods: DOP and OS were utilized to measure blood pressure values in nine anesthetized rhesus macaques, which were compared to direct measurements via a saphenous arterial catheter. Read More

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http://dx.doi.org/10.1111/jmp.12397DOI Listing
April 2019
2 Reads

Effect of maternal obesity on fetal and postnatal baboon (Papio species) early life phenotype.

J Med Primatol 2019 Apr 20;48(2):90-98. Epub 2018 Dec 20.

Texas Pregnancy and Life-course Health Center, Department of Animal Sciences, University of Wyoming, Laramie, Wyoming.

Background: Non-human primate models of developmental programming by maternal obesity (MO) are needed for translation to human programming outcomes. We present baboon offspring (F1) morphometry, blood cortisol, and adrenocorticotropic hormone (ACTH) from 0.9 gestation to 0-2 years. Read More

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http://dx.doi.org/10.1111/jmp.12396DOI Listing
April 2019
2 Reads

Characterization of Campylobacter jejuni, Campylobacter upsaliensis, and a novel Campylobacter sp. in a captive non-human primate zoological collection.

J Med Primatol 2019 Apr 9;48(2):114-122. Epub 2018 Dec 9.

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Background: The aim of this study was to longitudinally investigate the prevalence and characterization of Campylobacter spp. from non-human primates primate (NHP) with a history of endemic diarrhea housed at Como Park Zoo.

Methods: Fecal samples from 33 symptom-free NHP belonging to eight different species were collected weekly for 9 weeks. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jmp.12393
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http://dx.doi.org/10.1111/jmp.12393DOI Listing
April 2019
15 Reads

Molecular detection of Bifidobacterium spp. in faeces of black howler monkeys (Alouatta pigra).

J Med Primatol 2019 Apr 6;48(2):99-105. Epub 2018 Dec 6.

Sistemas Biológicos, Laboratorio de Biotecnología, Universidad Autónoma Metropolitana-Xochimilco, Coyoacán, CDMX, México.

Background: Bifidobacterium genus are considered to be beneficial bacteria for their hosts; however, knowledge about the specific species that are part of the gut microbiome of howler monkeys is scarce. Polymerase chain reaction (PCR) is a useful technique for the identification of non-cultivable or difficult to grow bacterial species. With the goal of detecting species of the genus Bifidobacterium in black howler monkeys, we used PCR on DNA derived from faecal samples. Read More

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http://dx.doi.org/10.1111/jmp.12395DOI Listing
April 2019
3 Reads

Hepatic neuroendocrine carcinoma in a Japanese macaque (Macaca fuscata).

J Med Primatol 2019 Apr 6;48(2):137-140. Epub 2018 Dec 6.

Primate Research Institute, Kyoto University, Aichi, Japan.

Primary neuroendocrine neoplasm of the liver is extremely rare in both humans and non-human primates. The present report describes the clinical and pathological findings of an aged Japanese macaque (Macaca fuscata) with hepatic neuroendocrine carcinoma. To our knowledge, this is the first report of hepatic neuroendocrine neoplasm in macaques. Read More

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http://doi.wiley.com/10.1111/jmp.12394
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http://dx.doi.org/10.1111/jmp.12394DOI Listing
April 2019
16 Reads

Hematological evaluation of free-living golden-headed lion tamarins (Leontopithecus chrysomelas) from an Urban Atlantic Forest.

J Med Primatol 2019 Apr 6;48(2):106-113. Epub 2018 Dec 6.

Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niteroi, RJ, Brazil.

Background: The Atlantic Forest where the animals were captured is surrounded by residences, so this close contact could favor the presence of disease-transmitting pathogens, putting the local population at risk. For these and other factors, it is important to perform laboratory tests enabling the performance of important diagnoses.

Methods: Blood samples of 268 golden-headed lion tamarins (Leontopithecus chrysomelas) inhabiting an Atlantic Forest area in Rio de Janeiro, Brazil, were processed for accessing age and sex influence in hematological parameters and to establish normative hematology values. Read More

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http://doi.wiley.com/10.1111/jmp.12392
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http://dx.doi.org/10.1111/jmp.12392DOI Listing
April 2019
21 Reads

Lipoid pneumonia in an orangutan (Pongo abelii) with chronic respiratory problems.

J Med Primatol 2019 Apr 16;48(2):133-136. Epub 2018 Nov 16.

Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

An orangutan (Pongo abelii) presented with chronic respiratory problems. Cytological evaluation of the bronchoalveolar lavage fluids revealed macrophages with well-circumscribed intracytoplasmic clear vacuoles and lipid droplets in the background, confirmed by Oil Red O staining. The findings were indicative of lipoid pneumonia. Read More

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http://doi.wiley.com/10.1111/jmp.12391
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http://dx.doi.org/10.1111/jmp.12391DOI Listing
April 2019
12 Reads

Bacterial endocarditis and increased cardiac troponin I levels in a brown howler monkey (Alouatta guariba clamitans) with an interventricular septal defect.

J Med Primatol 2019 Apr 8;48(2):129-132. Epub 2018 Nov 8.

Clinical Veterinary Hospital, School of Veterinary Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

A brown howler monkey (Alouatta guariba clamitans) was presented with lethargy, hyporexia, cough and heart murmur. The complementary tests and necropsy revealed pleuropneumonia, bacterial endocarditis and interventricular septal defect. To the best of our knowledge, this is the first report of increased cardiac troponin I levels in this species. Read More

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http://doi.wiley.com/10.1111/jmp.12390
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http://dx.doi.org/10.1111/jmp.12390DOI Listing
April 2019
11 Reads

Two case reports of unusual phimosis in rhesus monkeys (Macaca Mulatta).

J Med Primatol 2019 Feb 30;48(1):58-60. Epub 2018 Oct 30.

Department of Surgery and Radiology of Veterinary Medicine, University of Tehran, Tehran, Iran.

Phimosis is the inability of the penis to protrude from the prepuce. In the present report, we present two cases of phimosis in two rhesus monkeys. Surgical enlargement of preputial orifice was performed for unrestricted movement of penis. Read More

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http://doi.wiley.com/10.1111/jmp.12367
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http://dx.doi.org/10.1111/jmp.12367DOI Listing
February 2019
4 Reads

Gastrointestinal parasites of zoonotic importance observed in the wild, urban, and captive populations of non-human primates in Malaysia.

J Med Primatol 2019 Feb 29;48(1):22-31. Epub 2018 Oct 29.

Kenyir Research Institute, Universiti Malaysia Terengganu, Kuala Terengganu, Terengganu, Malaysia.

Background: A study was undertaken to determine gastrointestinal (GI) parasites commonly found in Malaysia's non-human primates (NHP) living in three different types of populations (wild, urban, and captive) and the basis of major GI parasites of zoonotic importance.

Methods: A total of 308 samples was collected and microscopically screened from the NHP in the wild (n = 163), urban (n = 76), and captive (n = 69) populations. The samples were taken from 12 species of local NHPs. Read More

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http://dx.doi.org/10.1111/jmp.12389DOI Listing
February 2019
2 Reads

Characterization of glucose-stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops).

J Med Primatol 2019 Feb 25;48(1):10-21. Epub 2018 Oct 25.

RxGen Inc., New Haven, Connecticut.

Background: Management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. These studies assessed different methodologies for determining glucose tolerance in green monkeys.

Methods: Twenty-eight African green monkeys between 4 and 24 years old underwent single or repeat intravenous glucose tolerance testing (IVGTT), oral glucose tolerance testing (OGTT), and/or graded glucose infusion testing. Read More

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http://doi.wiley.com/10.1111/jmp.12374
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http://dx.doi.org/10.1111/jmp.12374DOI Listing
February 2019
13 Reads

Developmental and family history-based analysis of congenital fused labia phenotype in the captive common marmoset (Callithrix jacchus).

J Med Primatol 2019 Feb 23;48(1):43-50. Epub 2018 Oct 23.

Laboratory of Biomedical Reproduction, German Primate Centre, Goettingen, Germany.

Background: Congenital fused labia (CFL) is defined as a failure or significant delay in the opening of the juvenile sealed labia majora. This phenotype is known to be variably common in adult captive female marmosets but has never been investigated in detail before.

Materials And Methods: Here, we define, describe and quantify the variations in the degree of closure of the vulva in 122 captive marmosets (Callithrix jacchus) from 1. Read More

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http://dx.doi.org/10.1111/jmp.12387DOI Listing
February 2019
5 Reads

Comparison of semen characteristics and sperm cryopreservation in common marmoset (Callithrix jacchus) and black-tufted-ear marmoset (Callithrix penicillata).

J Med Primatol 2019 Feb 21;48(1):32-42. Epub 2018 Oct 21.

Institute of Health Sciences, Paulista University, São Paulo, SP, Brazil.

Background: The common marmoset (Callithrix jacchus) is one of the most studied Neotropical primates regarding reproduction. However, little has been reported on the black-tufted-ear marmoset (Callithrix penicillata), which may produce fertile hybrids with other Callithrix. This is the first study to evaluate sperm freezing from black-tufted-ear marmoset. Read More

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http://dx.doi.org/10.1111/jmp.12388DOI Listing
February 2019
3 Reads

Perineal repair of a full-thickness rectal prolapse in a wild Sumatran orangutan (Pongo abelii).

J Med Primatol 2019 Feb 11;48(1):65-67. Epub 2018 Oct 11.

Wildlife Surgery International, Roslin, UK.

A Delorme's procedure perineal surgical repair was performed in a wild adult male Sumatran orangutan (Pongo abelii) with a chronic persistent rectal prolapse that had been unsuccessfully treated by 6 previous surgeries. The rectal prolapse did not recur, and the orangutan was successfully released to the wild, 6 weeks later. Read More

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http://doi.wiley.com/10.1111/jmp.12379
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http://dx.doi.org/10.1111/jmp.12379DOI Listing
February 2019
10 Reads

Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques.

J Med Primatol 2019 Feb 2;48(1):54-57. Epub 2018 Oct 2.

Center for Comparative Medicine, University of California, Davis, California.

Cervicovaginal bacteria cause inflammation which in turn increases HIV risk. Profiling the cervicovaginal microbiome, therefore, is instrumental for vaccine development. We show that the microbiome profile captured by cervicovaginal lavage is comparable to samples obtained by vaginal swabs. Read More

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http://dx.doi.org/10.1111/jmp.12381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326866PMC
February 2019
4 Reads

Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes.

J Med Primatol 2018 Oct 6;47(5):302-304. Epub 2018 Sep 6.

Harvard Medical School, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

The oral mucosae and draining lymph nodes are primary entry points for invading pathogens, particularly during immunosuppressive HIV/SIV infections. Innate immunity against oral stimuli, including natural killer (NK) cells, is understudied. Herein, we demonstrate functional NK cell responses to pathogen-associated molecular patterns (PAMPs) of potential oral pathogens in rhesus macaques. Read More

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http://dx.doi.org/10.1111/jmp.12371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161495PMC
October 2018
3 Reads

Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.).

J Med Primatol 2018 Dec 6;47(6):434-439. Epub 2018 Sep 6.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.

Multiple endocrine neoplasia (MEN) has not been reported in baboons, but this condition is well described in humans. An internal database was searched for all cases of concurrent endocrine hyperplasia and neoplasia in baboons. Twenty-four baboons (Papio spp. Read More

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http://doi.wiley.com/10.1111/jmp.12376
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http://dx.doi.org/10.1111/jmp.12376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234079PMC
December 2018
21 Reads

35th Annual Symposium on Nonhuman Primate Models for AIDS.

Authors:

J Med Primatol 2018 Oct;47(5):305-351

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http://dx.doi.org/10.1111/jmp.12383DOI Listing
October 2018
1 Read

Introduction.

J Med Primatol 2018 Oct;47(5):285

Tulane National Primate Research Center, Covington, LA, USA.

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http://dx.doi.org/10.1111/jmp.12384DOI Listing
October 2018
1 Read

SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.

J Med Primatol 2018 Oct;47(5):298-301

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.

How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4 T cells and adaptive genetic changes were observed during serial passages. Read More

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http://doi.wiley.com/10.1111/jmp.12380
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http://dx.doi.org/10.1111/jmp.12380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464631PMC
October 2018
3 Reads

Tribute to Bonnie Mathieson.

J Med Primatol 2018 Oct;47(5):286-287

National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Maryland.

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http://dx.doi.org/10.1111/jmp.12386DOI Listing
October 2018
2 Reads

Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney.

J Med Primatol 2019 Feb 25;48(1):51-53. Epub 2018 Sep 25.

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.

Flavin-containing monooxygenase 1 (FMO1) largely remains to be characterized in cynomolgus macaque kidney. Immunoblotting showed expression of cynomolgus FMO1 in kidneys where activities of FMO1 (benzydamine N-oxygenation) were detected. No sex differences were observed in their contents or activities. Read More

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http://dx.doi.org/10.1111/jmp.12385DOI Listing
February 2019
2 Reads

A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta.

J Med Primatol 2019 Feb 24;48(1):68-73. Epub 2018 Sep 24.

University of Cincinnati, Cincinnati, Ohio.

We present a case of hepatocellular carcinoma (HCC) in the placenta of healthy baboon (Papio spp.). Grossly, the fetal, maternal, and placental tissues were unremarkable. Read More

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http://dx.doi.org/10.1111/jmp.12382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392017PMC
February 2019
11 Reads

Determination of baseline values for routine ophthalmic tests in bearded capuchin (Sapajus libidinosus).

J Med Primatol 2019 Feb 19;48(1):3-9. Epub 2018 Sep 19.

Agricultural Science Center, Department of Veterinary Sciences, Federal University of Paraíba (UFPB), Areia, Brazil.

Background: Establish baseline values for ophthalmic diagnostic tests in Sapajus libidinosus.

Methods: Ophthalmic diagnostic tests, namely Schirmer tear test 1 (STT-1), intraocular pressure (IOP), B-mode ultrasound, culture of the bacterial conjunctival microbiota, and conjunctival exfoliative cytology, were performed in 15 S. libidinosus. Read More

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http://dx.doi.org/10.1111/jmp.12378DOI Listing
February 2019
3 Reads

Spontaneous retroperitoneal liposarcoma in a free-ranging juvenile golden-headed lion tamarin (Leontopithecus chrysomelas).

J Med Primatol 2019 Feb 19;48(1):61-64. Epub 2018 Sep 19.

Instituto Pri-Matas para a Conservação da Biodiversidade, Belo Horizonte, MG, Brasil.

Malignant adipocytic neoplasia is rare among nonhuman primates. We report the gross and microscopic features of a retroperitoneal liposarcoma with myxofibrosarcoma-like dedifferentiation in a free-ranging juvenile golden-headed lion tamarin (Leontopithecus chrysomelas). To our knowledge, this is the first report of such tumor subtype in New World primates. Read More

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http://dx.doi.org/10.1111/jmp.12377DOI Listing
February 2019
2 Reads

A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector-based vaccine induces simian immunodeficiency virus-specific systemic and mucosal immune responses in juvenile rhesus macaques.

J Med Primatol 2018 Oct 11;47(5):288-297. Epub 2018 Sep 11.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: A pediatric vaccine to prevent breast milk transmission of human immunodeficiency virus (HIV) may generate greater immune responses at viral entry sites if given by an oral route.

Methods: We compared immune responses induced in juvenile macaques by prime/boosting with simian immunodeficiency virus (SIV)-expressing DNA/modified vaccinia Ankara virus (MVA) by the intramuscular route (IM), the oral (O)/tonsillar routes (T), the O/sublingual (SL) routes, and O+IM/SL routes.

Results: O/T or O/SL immunization generated SIV-specific T cells in mucosal tissues but failed to induce SIV-specific IgA in saliva or stool or IgG in plasma. Read More

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http://dx.doi.org/10.1111/jmp.12372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158111PMC
October 2018
8 Reads

Eosinophilic aortitis with thoracic aortic aneurysm and rupture in a captive-born owl monkey.

J Med Primatol 2018 Dec 6;47(6):423-426. Epub 2018 Sep 6.

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Eosinophilic aortitis is a rare condition in animals and humans, and it has been occasionally reported associated with parasitic migration and with a poorly understood complex group of autoimmune vasculitides. Here, we describe a case of eosinophilic aortitis with thoracic aortic aneurysm and rupture in a captive-born owl monkey and discuss the differential diagnoses. Read More

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http://dx.doi.org/10.1111/jmp.12373DOI Listing
December 2018
9 Reads

Development and analytical validation of a radioimmunoassay for the quantification of alpha -proteinase inhibitor in serum and feces from the common marmoset (Callithrix jacchus).

J Med Primatol 2018 Dec 6;47(6):402-411. Epub 2018 Sep 6.

Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary and Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: The objective of this study was to develop and analytically validate a radioimmunoassay (RIA) for the measurement of alpha -proteinase inhibitor (α -PI) concentrations in serum and feces from the common marmoset.

Methods: Serum samples (n = 30) and 3-day fecal samples (n = 30) were obtained from healthy marmosets. An RIA was established and validated by determination of sensitivity, working range, dilutional parallelism, spiking recovery, and intra- and interassay variability. Read More

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http://dx.doi.org/10.1111/jmp.12375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234082PMC
December 2018
5 Reads

Human erythrocyte antigens in Brazilian Capuchin monkeys (Sapajus sp.).

J Med Primatol 2018 Dec 4;47(6):355-361. Epub 2018 Sep 4.

Center for the Study of Medicine and Wildlife Research, School of Veterinary Medicine and Zootechnics, São Paulo State University - UNESP, Botucatu, SP, Brazil.

Background: Investigation of erythrocyte antigens in New World monkeys, especially in the Brazilian ones, is scant and incomplete.

Methods: Determining the presence of 29 erythrocyte antigens from 11 human blood group systems (ABO, H, Rh, Kell, Duffy, Kidd, Lewis, P, MNS, Lutheran and Diego) on erythrocytes in nine Capuchin monkeys (Sapajus sp.). Read More

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http://dx.doi.org/10.1111/jmp.12369DOI Listing
December 2018
18 Reads

Tinea corporis by Microsporum audouinii in a female chimpanzee (Pan troglodytes) from Guinea-Bissau: A case report.

J Med Primatol 2018 Dec 24;47(6):419-422. Epub 2018 Aug 24.

CIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

We report a Microsporum audouinii infection in a female juvenile chimpanzee (Pan troglodytes) presenting generalized dermatitis compatible with dermatophytosis. Dermatophyte was identified by macro- and microscopic characterization of skin and scales cultures in Mycosel Agar. The topical treatment applied was effective, having the potential for dermatophytosis treatment in immunocompetent primates. Read More

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http://dx.doi.org/10.1111/jmp.12370DOI Listing
December 2018
6 Reads

Papio spp. Colon microbiome and its link to obesity in pregnancy.

J Med Primatol 2018 Dec 24;47(6):393-401. Epub 2018 Jul 24.

Department of Obstetrics and Gynecology, College of Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas.

Introduction: Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy. Read More

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http://dx.doi.org/10.1111/jmp.12366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430121PMC
December 2018
22 Reads

Evaluation of lacrimal production, osmolarity, crystallization, proteomic profile, and biochemistry of capuchin monkeys' tear film.

J Med Primatol 2018 Dec 24;47(6):371-378. Epub 2018 Jul 24.

School of Veterinary Medicine and Zootechny, Federal University of Bahia, Salvador, BA, Brazil.

Background: To evaluate the composition and characteristics of capuchin monkey (CM) tear film.

Methods: Eleven CM (Sapajus sp.) was evaluated. Read More

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http://dx.doi.org/10.1111/jmp.12368DOI Listing
December 2018
11 Reads

Molecular confirmation and anthelmintic efficacy assessment against natural trichurid infections in zoo-housed non-human primates.

J Med Primatol 2018 Dec 6;47(6):388-392. Epub 2018 Jul 6.

Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.

Introduction: This study aimed to assess Trichuris species infection and evaluate the anthelmintic efficacy of fenbendazole and ivermectin against natural trichurid infections in non-human primates (NHPs), kept at Mahendra Chaudhury (MC) Zoological Park, Chhatbir, India.

Materials And Methods: Molecular confirmation of Trichuris infection was carried out using polymerase chain reaction targeting internal transcribed spacer sequences, and anthelmintic efficacy was assessed by fecal egg count reduction test, respectively.

Results: A 710 base pair product confirmed Trichuris species infection in NHPs. Read More

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http://dx.doi.org/10.1111/jmp.12358DOI Listing
December 2018
2 Reads

Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen-free rhesus macaque (Macaca mulatta) colony based on massively parallel sequencing.

J Med Primatol 2018 Dec 4;47(6):379-387. Epub 2018 Jul 4.

Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.

Background: Knowledge of major histocompatibility complex (MHC) composition and distribution in rhesus macaque colonies is critical for management strategies that maximize the utility of this model for biomedical research.

Methods: Variation within the Mamu-A and Mamu-B (class I) and DRB, DQA/B, and DPA/B (class II) regions of 379 animals from the Caribbean Primate Research Center's (CPRC) specific pathogen free (SPF) colony was examined using massively parallel sequencing.

Results: Analyses of the 7 MHC loci revealed a background of Indian origin with high levels of variation despite past genetic bottlenecks. Read More

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http://dx.doi.org/10.1111/jmp.12353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234078PMC
December 2018
6 Reads