5,571 results match your criteria Journal of inorganic biochemistry[Journal]


Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3'-diindolylmethane ligand.

J Inorg Biochem 2019 Feb 13;194:1-6. Epub 2019 Feb 13.

Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany.

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate(IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondrial damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.005DOI Listing
February 2019

Polyoxomolybdates as α-glucosidase inhibitors: Kinetic and molecular modeling studies.

J Inorg Biochem 2019 Feb 8;193:173-179. Epub 2019 Feb 8.

College of Food and Biological Engineering, Jimei University, Xiamen 361021, PR China.

Noninsulin dependent diabetes mellitus is a serious global disease that is treated by inhibiting α-glucosidase to reduce the glucose content in the blood. Several incompletely satisfactory therapeutic drugs are already on the market. In this report, we showed that polyoxomolybdates based on Keggin-type architecture are promising candidates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183058
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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.001DOI Listing
February 2019
2 Reads

Facile synthesis of novel carbon-dots/hemin nanoplatforms for synergistic photo-thermal and photo-dynamic therapies.

J Inorg Biochem 2019 Feb 1;193:166-172. Epub 2019 Feb 1.

School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, PR China. Electronic address:

Due to the traditional therapies of cancer inducing huge pains to patients, the non-invasive photo-guided therapies are attracting massive attentions of researchers. Herein, the intelligent-designed carbon-dots/hemin nanoplatforms (HCDs NPs) were developed, owning high-authority photo-therapy for cancer. The fluorescence resonance energy transfer (FRET) effect enhanced the photo-thermal ability of HCDs NPs, endowing the synthesized nanoplatforms with photo-dynamic property simultaneously. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.018DOI Listing
February 2019

A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe, Al, Cu and Zn, and in vivo bioassays.

J Inorg Biochem 2019 Feb 6;193:152-165. Epub 2019 Feb 6.

Dipartimento di Chimica e Farmacia, Università di Sassari, Sassari, Italy.

This work presents the simple and low cost synthesis of a new tripodal ligand, in which three units of kojic acid are coupled to a tris(2-aminoethyl)amine (tren) backbone molecule. The protonation equilibria, together with the complex formation equilibria of this ligand with Fe, Al, Cu and Zn ions were studied. The complementary use of potentiometric, spectrophotometric and NMR techniques, and of Density Functional Theory (DFT) calculations, has allowed a thorough characterization of the different species involved in equilibrium. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.012DOI Listing
February 2019

Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation and apoptosis in the rat.

J Inorg Biochem 2019 Feb 1;193:143-151. Epub 2019 Feb 1.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Aluminum (Al) causes hippocampal lesions by oxidative stress, which is widely accepted as the primary pathogenesis of Al neurotoxicity. Lycopene (LYC), a naturally carotenoid, has received extensive attention due to its antioxidant effect. In this study, the neuroprotective effects and mechanisms of LYC against aluminum chloride (AlCl)-induced hippocampal lesions were explored. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.017DOI Listing
February 2019
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A cisplatin-based platinum(IV) prodrug containing a glutathione s-transferase inhibitor to reverse cisplatin-resistance in non-small cell lung cancer.

J Inorg Biochem 2019 Jan 29;193:133-142. Epub 2019 Jan 29.

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189, China. Electronic address:

A Pt(IV) prodrug of cisplatin containing a glutathione s-transferase (GSTs) inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX), complex 1, was designed and studied aiming to overcome cisplatin-resistance and reduce its toxicity by inhibiting GSTs overexpressed in cancer cells. The complex could be reduced to release its active Pt(II) species and axial ligand in the presence of ascorbic acid. In cytotoxicity study, complex 1 showed more potent anticancer activity than cisplatin and NBDHEX against all the tested cancer cells, especially toward cisplatin resistant A549/DDP cells with a resistance factor value of 0. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.014DOI Listing
January 2019
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A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities.

J Inorg Biochem 2019 Jan 28;193:130-132. Epub 2019 Jan 28.

Institute of POM-based Materials, Hubei Provincial Key Laboratory of Green Materials for Light Industry, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Sino-German Biomedical Center, Hubei University of Technology, Wuhan 430068, China. Electronic address:

A new strategy to construct polyoxovanadate hybrids incorporating amino acid esters in mild conditions was presented in this paper. These new hybrids were not only structurally determined by Single Crystal X-Ray diffraction, but also exhibited higher antitumor activities against laryngeal carcinoma, rhabdomyoma, and breast adenocarcinoma tumor cells compared with the traditional commercial medicine 5-fluorouracil. These results would provide a promising lead scaffold for further design and synthesis of potential anticancer agents. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.013DOI Listing
January 2019
3.444 Impact Factor

Photochemical property of two Ru(II) compounds based on 5-(2-pyrazinyl)tetrazole for cancer phototherapy by changing auxiliary ligand.

J Inorg Biochem 2019 Jan 28;193:124-129. Epub 2019 Jan 28.

Jiangsu Laboratory of Advanced Functional Material, Department of Chemistry and Material Engineering, Changshu Institute of Technology, Changshu 215500, Jiangsu, PR China; School of Pharmacy, Guilin Medical University, Guilin 541004, Guangxi, PR China. Electronic address:

Ru(II) compounds are potential candidates for photodynamic therapy (PDT) and auxiliary ligands may have an impact on the property of the resulting coordination compounds. In the present study, two Ru(II) compounds based on 5-(2-pyrazinyl)tetrazole (Hpztz) and two classic auxiliary ligands, 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen) have been prepared and characterized, namely [Ru(pztz)(bipy)][PF] (1) and [Ru(pztz)(phen)][PF] (2). The nanoparticles (NPs) of the two compounds have been prepared by self-assembly in aqueous solution. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.015DOI Listing
January 2019

Ruthenium(II) salicylate complexes inducing ROS-mediated apoptosis by targeting thioredoxin reductase.

J Inorg Biochem 2019 Jan 25;193:112-123. Epub 2019 Jan 25.

Dongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. Electronic address:

Thioredoxin reductase (TrxR), a major component of the thioredoxin system, makes a critical role in regulating cellular redox signaling and is found to be overexpressed in many human cancer cells. TrxR has become an attractive target for anticancer agents. In this work, three Ru(II) complexes with salicylate as ligand, [Ru(phen)(SA)] (phen = 1,10-phenanthroline, SA = salicylate, 1), [Ru(dmb)(SA)] (dmb = 4,4'-dimethyl-2,2'-bipyridine, 2) and [Ru(bpy)(SA)] (bpy = 2,2'-bipyridine, 3), were synthesized and characterized. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.011DOI Listing
January 2019
1 Read

Synthesis, characterization and biological evaluation of Co(III) complexes with quinolone drugs.

J Inorg Biochem 2019 Jan 21;193:94-105. Epub 2019 Jan 21.

Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4032 Debrecen, Egyetem tér 1, Hungary. Electronic address:

Nine novel cobalt(III) ternary complexes bearing 4N donor ligands (tris(2-aminoethyl)amine (tren) or tris(2-methylpyridyl)amine (tpa)) and (fluoro)quinolones (quinH) with antibacterial and potential antitumor activity have been synthesized, characterized and screened in various biological assays. The molecular structures of [Co(tpa)(nal)](PF) (3) and [Co(tpa)(nor)(Co(tpa)(norH)](PF)(Cl)∙5MeOH (8) (nal = deprotonated form of nalidixic acid, norH = norfloxacin) with the expected octahedral geometry and (O,O) coordination of the quinolone ligands are also reported. Cyclic voltammetric studies revealed that the 4N donor ligands have much higher effect on the reduction potential of these ternary complexes than the quinolones. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.005DOI Listing
January 2019

Liver pathology in Wilson's disease: From copper overload to cirrhosis.

J Inorg Biochem 2019 Jan 15;193:106-111. Epub 2019 Jan 15.

Division of Pathological, University of Cagliari AOU Cagliari, Cagliari, Italy.

Wilson's disease (WD) is a genetic metabolic disease strictly associated with liver cirrhosis. In this review, the genetic bases of the disease are discussed, with emphasis on the role of ATP7B (the Wilson disease protein) dysfunction as a determinant factor of systemic copper overload. Regarding the different multiple mutations described in WD patients, the peculiarity of Sardinian population is highlighted, Sardinians carrying a rare deletion in the promoter (5' UTR) of the WD gene. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.008DOI Listing
January 2019
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An in vitro study on dentin demineralization and remineralization: Collagen rearrangements and influence on the enucleated phase.

J Inorg Biochem 2019 Jan 18;193:84-93. Epub 2019 Jan 18.

Biochemistry Unit, Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Belmeloro 8/2, 40126 Bologna, Italy. Electronic address:

Dentin remineralization is of clinical relevance in the therapy of caries and dentin hypersensitivity. This study is aimed at gaining more insights on a molecular scale, through IR spectroscopy, into dentin demineralization and remineralization. The dentin demineralization by ethylenediaminetetraacetic acid, EDTA (17%, 2 h) significantly altered the secondary structure distribution of collagen, upon loss of interaction with calcium ions. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.004DOI Listing
January 2019
1 Read

Ru(II)/N-N/PPh complexes as potential anticancer agents against MDA-MB-231 cancer cells (N-N = diimine or diamine).

J Inorg Biochem 2019 Jan 18;193:70-83. Epub 2019 Jan 18.

Universidade Federal de São Carlos, Departamento de Química, São Carlos, SP, Brazil. Electronic address:

The rational design of anticancer agents that acts in specific biological targets is one of the most effective strategies for developing chemotherapeutic agents. Aiming at obtaining new ruthenium (II) compounds with good cytotoxicity against tumor cells, a series of new complexes of general formula [RuCl(PPh)(Hdpa)(NN)]Cl [PPh = triphenylphosphine, N-N = 2,2'-dipyridylamine (Hdpa) (1), 1,2-diaminoethane (en) (2), 2,2'-bipyridine (bipy) (3), 5,5'-dimethyl-2,2'-bipyridine (dmbipy) (4), 1,10-phenanthroline (phen) (5) and 4,7-diphenyl-1,10-phenanthroline (dphphen) (6)] were synthesized. The complexes were characterized by elemental analysis and spectroscopic techniques (IR, UV/Visible, and 1D and 2D NMR) and three of their X-ray structures were determined: [RuCl(PPh)(Hdpa)]Cl, [RuCl(PPh)(Hdpa)(en)]Cl and [RuCl(PPh)(Hdpa)(dmbipy)]Cl. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.006DOI Listing
January 2019
1 Read

Mir-215-5p induces autophagy by targeting PI3K and activating ROS-mediated MAPK pathways in cardiomyocytes of chicken.

J Inorg Biochem 2019 Jan 18;193:60-69. Epub 2019 Jan 18.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, PR China. Electronic address:

Our previous study revealed that selenium (Se) deficiency can cause myocardial injury through triggering autophagy. MicroRNAs (miRNAs) play crucial roles in autophagic cell death. However, the relationship between miRNAs and myocardial autophagy injury caused by Se deficiency remains unclear. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.010DOI Listing
January 2019
2 Reads
3.444 Impact Factor

Syntheses, crystal structures and biological evaluation of two new Cu(II) and Co(II) complexes based on (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-6-methoxyphenol.

J Inorg Biochem 2019 Jan 15;193:52-59. Epub 2019 Jan 15.

Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China. Electronic address:

Two transition metal complexes of [M(TMP)(HO)] (TMP-Cu, M = Cu; TMP-Co, M = Co) with (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-6-methoxyphenol (H-TMP) were first synthesized and characterized by infrared analysis, elemental analysis and single crystal X-ray diffraction analysis. Notably, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay showed that TMP-Cu displayed relatively high cytotoxic activity against Hep-G2 cancer cells, and high selectivity between human hepatocellular carcinoma cells and normal HL-7702 cells, in comparison to TMP-Co and cisplatin. Further studies showed that TMP-Cu and TMP-Co caused cell cycle arrest at S phase through regulation of S phase related protein expressions and induced Hep-G2 cell apoptosis via the mitochondrial pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183064
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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.009DOI Listing
January 2019
5 Reads

Photoinduced electron transfer within supramolecular hemoprotein co-assemblies and heterodimers containing Fe and Zn porphyrins.

J Inorg Biochem 2019 Jan 14;193:42-51. Epub 2019 Jan 14.

Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan. Electronic address:

Electron transfer (ET) events occurring within metalloprotein complexes are among the most important classes of reactions in biological systems. This report describes a photoinduced electron transfer between Zn porphyrin and Fe porphyrin within a supramolecular cytochrome b (Cyt b) co-assembly or heterodimer with a well-defined rigid structure formed by a metalloporphyrin-heme pocket interaction and a hydrogen-bond network at the protein interface. The photoinduced charge separation (CS: k = 320-600 s) and subsequent charge recombination (CR: k = 580-930 s) were observed in both the Cyt b co-assembly and the heterodimer. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.001DOI Listing
January 2019

Supramolecular redox-responsive substrate carrier activity of a ferrocenyl Janus device.

J Inorg Biochem 2019 Jan 11;193:31-41. Epub 2019 Jan 11.

Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China; National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China. Electronic address:

Supramolecular Janus compounds have recently attracted increasing attention owing to their dynamic reversible properties, distinct topological structures, and remarkable physicochemical characteristics, e.g., amphiphilicity, heterofunctionality, and high-density of terminal groups. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.018DOI Listing
January 2019

Complexation of luteolin with lead (II): Spectroscopy characterization and theoretical researches.

J Inorg Biochem 2019 Jan 15;193:25-30. Epub 2019 Jan 15.

School of Food Science and Engineering, Northwest University, 229 North TaiBai Road, Xi'an 710069, China; Bee Product Research Center of Shaanxi Province, Xi'an 710065, China. Electronic address:

The interactions of (CHCOO)Pb·3HO (lead acetate trihydrate) with luteolin, 5,7,3',4'-tetrahydroxyflavone, were investigated in methanol solution. The spectroscopy (UV-Vis, FT-IR, HPLC-MS, H NMR) and elemental analysis were adopted to assess the interaction of luteolin and Pb(II). The results show that luteolin reacts with Pb(II) through the chelating sites of 4‑carbonyl and 5-hydroxy in two luteolin molecules. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.007DOI Listing
January 2019
3.444 Impact Factor

Dinuclear copper(II) complexes of "end-off" bicompartmental ligands: Alteration of the chelating arms on ligands to regulate the reactivity of the complexes towards DNA.

J Inorg Biochem 2019 Mar 30;192:126-139. Epub 2018 Dec 30.

School of Chemistry and Chemical Engineering, Building Materials Research Academy, Yancheng Institute of Technology, Jianjun East Rd. 211, Yancheng 224051, PR China. Electronic address:

Two phenol-based "end-off" biscompartmental heptadentate ligands were designed by introduction of substituents with different electronic and steric properties to the chelating arms, i.e. 2,6-bis{[(2-pyridylmethyl)(2-hydroxyethyl)amino]methyl}-4-methylphenol (L) and 2,6-bis{[(2-aminoethyl)(2-hydroxyethyl)amino]methyl}-4-methylphenol (L). Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.014DOI Listing
March 2019
1 Read

N‑(6‑Aminohexyl)‑5‑chloro‑1‑naphthalenesulfonamide, a centrin antagonist, inhibits Tb/peptides-binding properties.

J Inorg Biochem 2019 Jan 11;193:15-24. Epub 2019 Jan 11.

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Taiyuan 030006, China. Electronic address:

N‑(6‑Aminohexyl)‑5‑chloro‑1‑naphthalenesulfonamide (W-7), a kind of adjuvant chemotherapy, can bind to calmodulin and inhibit Ca/calmodulin-regulated enzyme activities and cell proliferation. Similar to calmodulin, euplotes octocarinatus centrin (EoCen) belongs to EF-hand superfamily of calcium-binding proteins. It is associated with nucleotide excision repair (NER), cell division cycle and ciliogenesis. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.002DOI Listing
January 2019

DFT modeling of the prevention of Fe(II)-mediated redox damage by imidazole-based thiones and selones.

J Inorg Biochem 2019 Jan 3;193:9-14. Epub 2019 Jan 3.

Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529, United States of America.. Electronic address:

Peroxide reduction involving Fe(II) (i.e., Fenton chemistry) forms hydroxyl radicals which cause oxidative damage to DNA in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183054
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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.015DOI Listing
January 2019
3 Reads

Synthesis, anticancer activity and mechanism of iron chelator derived from 2,6-diacetylpyridine bis(acylhydrazones).

J Inorg Biochem 2019 Jan 10;193:1-8. Epub 2019 Jan 10.

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:

We synthesized five iron chelator derived from 2,6-diacetylpyridine bis(acylhydrazones) and proved their iron complexes structure by X-ray single crystal diffraction. These ligands have a significant anticancer proliferative activity and low cytotoxicity against normal cells. The Fe(III) complexes show reduced cytotoxic activity compared to the metal-free ligands. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.003DOI Listing
January 2019

Functionalization of luminescent lanthanide-gallium metallacrowns using copper-catalyzed alkyne-azide cycloaddition and thiol-maleimide Michael addition.

J Inorg Biochem 2019 Mar 23;192:119-125. Epub 2018 Dec 23.

Willard H. Dow Laboratories, University of Michigan, 930 N. University Ave., Ann Arbor, MI, USA. Electronic address:

The synthesis and characterization of {Ln[12-MC-4]}(iph) and {Ln[12-MC-4]}(miph) metallacrowns (MCs), where shi is salicylhydroximate, eshi is 4-ethynylsalicylhydroximate, iph is isopthalate, and miph is 5-maleimidoisophthalate, is reported. The ethynyl functionality allows for coupling of MCs to azides using copper(I) catalyzed alkyne-azide cycloaddition (CuAAC), while the maleimido functionality allows for coupling of the MCs to thiol-bearing compounds. We demonstrate these coupling reactions using benzyl azide for the former and cysteamine for the latter, with complete conversion shown by ESI-MS. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.011DOI Listing

In vitro anti-bacterial and time kill evaluation of binuclear tricyclohexylphosphanesilver(I) dithiocarbamates, {CyPAg(SCNRR')}.

J Inorg Biochem 2019 Mar 6;192:107-118. Epub 2019 Jan 6.

Research Centre for Crystalline Materials, School of Science and Technology, Sunway University, No. 5 Jalan Universiti, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia. Electronic address:

Four binuclear phosphanesilver(I) dithiocarbamates, {cyclohexylPAg(SCNRR')} for R = R' = Et (1), CHCH (2), CHCHOH (3) and R = Me, R' = CHCHOH (4) have been synthesised and characterised by spectroscopy and crystallography, and feature tri-connective, μ-bridging dithiocarbamate ligands and distorted tetrahedral geometries based on PS donor sets. The compounds were evaluated for anti-bacterial activity against a total of 12 clinically important pathogens. Based on minimum inhibitory concentration (MIC) and cell viability tests (human embryonic kidney cells, HEK 293), 1-4 are specifically active against Gram-positive bacteria while demonstrating low toxicity; 3 and 4 are active against methicillin resistant S. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.017DOI Listing
March 2019
2 Reads

ZraP, the most prominent zinc protein under zinc stress conditions has no direct role in in-vivo zinc tolerance in Escherichia coli.

J Inorg Biochem 2019 Mar 27;192:98-106. Epub 2018 Dec 27.

Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, the Netherlands. Electronic address:

Escherichia coli ZraP (zinc resistance associated protein) is the major Zn containing soluble protein under Zn stress conditions. ZraP is the accessory protein of a bacterial two-component, Zn sensitive signal transduction system ZraSR. ZraP has also been reported to act as a Zn dependent molecular chaperone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183057
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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.013DOI Listing
March 2019
1 Read

Copper complexes for biomedical applications: Structural insights, antioxidant activity and neuron compatibility.

J Inorg Biochem 2019 Mar 26;192:87-97. Epub 2018 Dec 26.

Department of Chemistry, Université du Québec à Montréal, C.P. 8888, Succ. Centre-Ville, Montréal, Québec H3C 3P8, Canada; Research Chair in Enteric Dysfunctions "Allerdys", Centres Pharmaqam and CERMO-FC, Université du Québec à Montréal, C.P. 8888, Montréal, Québec H3C 3P8, Canada. Electronic address:

Copper coordinated with amino acid residues is essential for the function of many proteins. In addition, copper complexed to free l-Histidine, as [Cu(His)], is used in the treatment of the neurodegenerative Menkes disease and of cardioencephalomyopathy. This study was aimed to coordinate copper(II) with four small ligands (l-Serine, l-Histidine, Urea and Biuret) and to evaluate structural features, stability, antioxidant activity and neuronal compatibility of the resulting complexes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183040
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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.010DOI Listing
March 2019
8 Reads

Synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes: A small modification at tetrazole C5 markedly influences the in vivo antitumor efficacy.

J Inorg Biochem 2019 Mar 23;192:82-86. Epub 2018 Dec 23.

Department of Pharmaceutical Organic Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address:

We synthesized and characterized 15 new derivatives of the highly anticancer-active platinum(II) complex [{cis-Pt(NH)}(μ-OH)(μ-tetrazolato-N2,N3)] (5-H-Y) by making substitutions at tetrazole C5. We then evaluated the comprehensive structure-cytotoxicity relationships of a total of 23 derivatives in two murine lymphocytic leukaemia cell lines, sensitive and resistant to cisplatin. We also report the in vivo antitumor efficacy of three ester derivatives, two of which exhibited much higher efficacy than oxaliplatin against mouse homografted Colon-26 colorectal tumor. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.009DOI Listing

An inorganic magnetic fluorescent nanoprobe with favorable biocompatibility for dual-modality bioimaging and drug delivery.

J Inorg Biochem 2019 Mar 10;192:72-81. Epub 2018 Dec 10.

MOE Key Laboratory of Interface Science and Engineering in Advanced Materials, Research Center of Advanced Materials Science and Technology, Taiyuan University of Technology, No. 79 Yingze West Street, Taiyuan 030024, China. Electronic address:

In this work, we present the development of a high water soluble biological nanoprobe through the covalent bonding of β-CD onto the surface of iron oxide‑gold nanoclusters (FeO@Au@β-CD). FeO@Au@SiO NPs were also prepared for comparison. The maximum emission peak of magnetic fluorescent NPs red-shifted by 30 nm and the lifetime was also elongated to 5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183041
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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.002DOI Listing
March 2019
8 Reads

Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis.

J Inorg Biochem 2019 Mar 26;192:62-71. Epub 2018 Dec 26.

College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province 271018, China. Electronic address:

Cadmium (Cd) is a ubiquitously distributed environmental pollutant that is highly toxic to liver. Trehalose (Tr), a novel autophagy activator, has been shown to exert cytoprotective effect in numerous pathological processes. However, it is yet to be established whether Tr affords protection against Cd-induced hepatotoxicity. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.008DOI Listing

Half-sandwich iridium(III) complexes with α-picolinic acid frameworks and antitumor applications.

J Inorg Biochem 2019 Mar 24;192:52-61. Epub 2018 Dec 24.

Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China. Electronic address:

Eight half-sandwich iridium (Ir) complexes of the general formula [(η-Cp)Ir(O^N)Cl] (Cp is tetramethyl(biphenyl)cyclopentadienyl, and the O^N is α-picolinic acid chelating ligand and its derivatives) were synthesized and characterized. Compared with cis-platin widely used in clinic, target Ir complexes showed at most five times more potent antitumor activity against A549 cells by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Ir complexes could be transported by serum albumin, bind with DNA, catalyze the oxidation of nicotinamide-adenine dinucleotid (NADH) and induce the production of reactive oxygen species, which confirmed the antitumor mechanism of oxidation. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.012DOI Listing

Interaction of Cm(III) with human serum albumin studied by time-resolved laser fluorescence spectroscopy and NMR.

J Inorg Biochem 2019 Mar 20;192:45-51. Epub 2018 Dec 20.

Karlsruhe Institute of Technology (KIT), Institute for Nuclear Waste Disposal (INE), P.O. Box 3640, 76021 Karlsruhe, Germany; University of Heidelberg, Institute of Physical Chemistry, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany.

The complexation of Cm(III) with human serum albumin (HSA) was investigated using time-resolved laser fluorescence spectroscopy (TRLFS). The Cm(III) HSA species is dominating the speciation between pH 7.0 and 9. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.007DOI Listing

Does phosphorylation increase the binding affinity of aluminum? A computational study on the aluminum interaction with serine and O-phosphoserine.

J Inorg Biochem 2019 Mar 15;192:33-44. Epub 2018 Dec 15.

Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU), P.K. 1072, 20080 Donostia, Euskadi, Spain; Donostia International Physics Centre (DIPC), Donostia 20018, Euskadi, Spain.

Several toxic effects arise from aluminum's presence in living systems, one of these effects is to alter the natural role of enzymes and non-enzyme proteins. Aluminum promotes the hyperphosphorylation of normal proteins. In order to assess the aluminum-binding abilities of phosphorylated proteins and peptides, the interaction of aluminum at different pH with serine and phosphoserine is studied by a Density Functional Theory study, combined with polarizable continuum models to account for bulk solvent effects, and the electronic structure of selected complexes are analyzed by Quantum Theory of "Atoms in Molecules". Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.004DOI Listing

About the use of C-C NOESY in bioinorganic chemistry.

J Inorg Biochem 2019 Mar 8;192:25-32. Epub 2018 Dec 8.

CERM, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy; Department of Chemistry "Ugo Schiff", University of Florence Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

Herein we present examples of the application of the C-C Nuclear Overhauser Effect Spectroscopy (NOESY) experiment to the study of metalloproteins and we critically discuss the advantages and drawbacks of the method as a function of the molecular size of the investigated systems. The contribution is focused on a few case studies among the systems analyzed in the group of the corresponding author. The C-C NOESY experiment represents the gold standard for the observation of NMR signals in the 480 kDa ferritin nanocage and for monitoring its interaction with iron. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.006DOI Listing
March 2019
1 Read

Synthesis, characterization, DNA binding, topoisomerase I inhibition and antiproliferation activities of three new functionalized terpyridine platinum(II) complexes.

J Inorg Biochem 2019 Mar 7;192:17-24. Epub 2018 Dec 7.

Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, PR China. Electronic address:

Three new platinum(II) complexes with pendent morpholine were synthesized, namely complex 1 ([Pt(L)Cl]CFSO), complex 2 ([Pt(L)(NH)](CFSO)) and complex 3 ([Pt(L)(PPh)](CFSO)), where L = 4'-[4-(4-morpholinobutyloxy)phenyl]-2,2':6',2″-terpyridine and PPh = triphenylphosphine. The detailed molecular structures of complex 3, L and its precursor L' (1,4'-[4-(4-bromobutyloxy)phenyl]-2,2':6',2″-terpyridine) were determined by single crystal X-ray diffraction. An evaluation of in vitro cytotoxicity for both ligand and complexes was performed by methyl thiazolyl tetrazolium (MTT) assay in three cancer cell lines and normal cells as the control, respectively. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.003DOI Listing

Triphenyltin(IV) acylhydrazone compounds: Synthesis, structure and bioactivity.

J Inorg Biochem 2019 Feb 24;191:194-202. Epub 2018 Nov 24.

Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China. Electronic address:

Four new triphenyltin(IV) acylhydrazone compounds of the type PhSnCHCHCONHN=R (where Ph = phenyl; R = isopropyl, isobutyl, cyclopentyl and cyclooctyl) were synthesized and characterized by elemental analysis, infrared spectrum (IR), nuclear magnetic resonance spectrum (NMR) and mass spectrum (MS). The crystal structures were determined and showed that tin atoms were four-coordinated and adopted a pseudo-tetrahedron configuration. Tin(IV) compounds show excellent bovine serum albumin (BSA) binding properties, and can oxidize nicotinamide-adenine dinucleotid (NADH) to generate reactive oxygen species (ROS), which inducing apoptosis effectively. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.011DOI Listing
February 2019
6 Reads

Synthesis, photodynamic activities, and cytotoxicity of new water-soluble cationic gallium(III) and zinc(II) phthalocyanines.

J Inorg Biochem 2019 Mar 5;192:7-16. Epub 2018 Dec 5.

Department of Chemistry, Graduate School of Science and Engineering, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan. Electronic address:

The cationic Ga(III) and Zn(II) phthalocyanines carrying N-methyl-pyridinium groups at eight peripheral β-positionshave been synthesized. These complexes are highly soluble in dimethyl sulfoxide (DMSO) and moderately soluble in water and phosphate buffered saline (PBS); both Ga(III)Cl and Zn(II) complexes have shown no aggregation in water up to 1.2 × 10 and 1. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.013DOI Listing
March 2019
3 Reads

A series of two-photon absorption organotin (IV) cyano carboxylate derivatives for targeting nuclear and visualization of anticancer activities.

J Inorg Biochem 2019 Mar 5;192:1-6. Epub 2018 Dec 5.

Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, PR China. Electronic address:

Compared to organotin (IV) compounds with biochemical activity, two-photon absorption (2PA) organotin (IV) complexes for targeting nuclear with anticancer activities are rarely reported. Here, two novel 2PA organotin (IV) cyano carboxylate complexes (C1Sn-1, C1Sn-2) are synthesized and characterized. The two-photon absorption cross section values (δ) in the near-infrared region are significantly enhanced for C1Sn-2 compared to C1Sn-1 thus developing for targeting nuclear by two-photon fluorescence microscopy (2PFM). Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.001DOI Listing
March 2019
1 Read

In-vitro evaluation studies of 7-chloro-4-aminoquinoline Schiff bases and their copper complexes as cholinesterase inhibitors.

J Inorg Biochem 2019 Feb 30;191:183-193. Epub 2018 Nov 30.

Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-141 Niterói, RJ, Brazil. Electronic address:

Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders. Aggregation of amyloid-β peptide into extracellular plaques with incorporation of metal ions, such as Cu, and reduction of the neurotransmitter acetylcholine levels are among the factors associated to the AD brain. Hence, a series of 7-chloro-4-aminoquinoline Schiff bases (HLa-e) were synthesized and their cytotoxicity and anti-cholinesterase activity, assessed for Alzheimer's disease. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.019DOI Listing
February 2019

Structure-activity relationships of 2‑quinolinecarboxaldehyde thiosemicarbazone gallium(III) complexes with potent and selective anticancer activity.

J Inorg Biochem 2019 Feb 28;191:174-182. Epub 2018 Nov 28.

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. Electronic address:

Six gallium(III) complexes (Ga1-Ga6) with 2‑quinolinecarboxaldehyde thiosemicarbazone analogues were synthesized and characterized. These gallium(III) complexes exhibited potent anticancer activity and exceeded that of the corresponding metal free ligands. Importantly, these gallium(III) complexes have a strong selectivity for tumor cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183047
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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.017DOI Listing
February 2019
4 Reads

Evaluation of PTA-derived ruthenium(II) and iridium(III) quinoline complexes against chloroquine-sensitive and resistant strains of the Plasmodium falciparum malaria parasite.

J Inorg Biochem 2019 Feb 27;191:164-173. Epub 2018 Nov 27.

Chemical Physics, Department of Chemistry, Lund University, Box 124, SE-221 00 Lund, Sweden. Electronic address:

Cationic 1,3,5‑triaza‑phosphaadamantane (PTA) quinoline ruthenium(II) and iridium(III) complexes were successfully synthesized and characterized using standard spectroscopic and analytical techniques. The complexes were evaluated for their in vitro antiplasmodial activities against the chloroquine-sensitive (CQS) NF54 and chloroquine-resistant (CQR) K1 strains of the Plasmodium falciparum species of the malaria parasite and were found to exhibit good activities in the sensitive strain but moderate activities in the resistant strain, suggesting a resistance mechanism similar to chloroquine (CQ). Selected samples were screened for their ability to inhibit synthetic haemozoin formation and were found to be inhibitors with similar activity to CQ. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.018DOI Listing
February 2019
2 Reads

Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide.

J Inorg Biochem 2019 Feb 15;191:154-163. Epub 2018 Nov 15.

Institut Pasteur, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, CNRS UMR3523, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France. Electronic address:

The identification of synthetic nucleotides that sustain the formation of orthogonal, unnatural base pairs is an important goal in synthetic biology. Such artificial synthons have been used for the generation of semi-synthetic organisms as well as functional nucleic acids with enhanced binding properties. The enzymatic formation of artificial metal-base pairs is a vastly underexplored and alluring alternative to existing systems. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.009DOI Listing
February 2019

How copper ions and membrane environment influence the structure of the human and chicken tandem repeats domain?

J Inorg Biochem 2019 Feb 23;191:143-153. Epub 2018 Nov 23.

Opole Medical School in Opole, Katowicka 68, 45060 Opole, Poland.

Prion proteins (PrPs) from different species have the enormous ability to anchor copper ions. The N-terminal domain of human prion protein (hPrP) contains four tandem repeats of the -PHGGGWGQ- octapeptide sequence. This octarepeat domain can bind up to four Cu ions. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.012DOI Listing
February 2019

Engineering of pectin-dopamine nano-conjugates for carrying ruthenium complex: A potential tool for biomedical applications.

J Inorg Biochem 2019 Feb 28;191:135-142. Epub 2018 Nov 28.

Institute of Environmental Toxicology and Environmental Ecology, Yancheng Teachers University, Yancheng City, Jiangsu Province 224007, People's Republic of China. Electronic address:

In this work, we designed polysaccharide-metal complex of dopamine-modified pectin linking ruthenium compound, which exhibited a certain inhibition specificity to human renal cell adenocarcinoma cell line 786-O. The chemical structure and physical properties of the polysaccharide-metal complex were well characterized by multiple analysis methods. The multi-spectral results revealed that pectin-dopamine have been successfully coordinated by ruthenium complex to form nano-conjugates, which self-assembled into relatively regular nanospheres of approximately 200 nm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183050
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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.016DOI Listing
February 2019
9 Reads

A ruthenium(II) complex containing a p-cresol group induces apoptosis in human cervical carcinoma cells through endoplasmic reticulum stress and reactive oxygen species production.

J Inorg Biochem 2019 Feb 28;191:126-134. Epub 2018 Nov 28.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address:

The chemical structures of Ru (II) complexes are known to affect their cellular behavior and toxicity. In this study, three new luminescent Ru (II) complexes, [Ru(bpy)(HIPMP)](ClO) (Ru1, bpy = 2,2'-bipyridine, HIPMP = 2-(1H-imidazo-[4,5-f] [1,10] phenanthrolin-2-yl)-4-methylphenol), [Ru(phen)(HIPMP)](ClO) (Ru2, phen = 1,10-phenanthroline), [Ru(dmb)(HIPMP)](ClO) (Ru3, dmb = 4,4'-dimethyl-2,2'-bipyridine), were synthesized, and their anticancer activities were examined. All three complexes displayed anticancer activities against various cancer cells, with Ru2 exhibiting the highest cytotoxic activities. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.015DOI Listing
February 2019
3 Reads

Redox dyshomeostasis in the experimental chronic hepatic overloads with iron or copper.

J Inorg Biochem 2019 Feb 23;191:119-125. Epub 2018 Nov 23.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

Male rats of 80-90 g were overloaded with either Fe(II) or Cu(II) for 42 days by high concentrations of FeCl or CuSO in the drinking water. The animals were fed with a commercial rodent diet of 2780 kcal/100 g. Both metal treatments led to a liver redox imbalance and dyshomeostasis with oxidative stress and damage and the concomitant enhancement of oxidative processes as indicated by in vivo surface liver chemiluminescence, the sensitive and organ non-invasive assay for oxidative free radical reactions, and by ex vivo determined processes of phospholipid peroxidation and protein oxidation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183055
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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.014DOI Listing
February 2019
11 Reads

Novel structures of platinum complexes bearing N‑bisphosphonates and study of their biological properties.

J Inorg Biochem 2019 Feb 18;191:112-118. Epub 2018 Nov 18.

Inorganic Chemistry Department, Universidad Autónoma de Madrid, 28049, Spain. Electronic address:

Novel bisphosphonate platinum complexes: [Pt(isopropylamine)(BP)]NO (BP = pamidronate and alendronate) have been synthesized and characterized. Their monomeric structure contains a bisphosphonate acting as chelate ligand through its oxygen atom donors, conferring the compound's cationic structure with a good solubility in water. The study of the compounds in solution showed high stability up to 24 h. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.010DOI Listing
February 2019
1 Read

In-depth synthetic, physicochemical and in vitro biological investigation of a new ternary V(IV) antioxidant material based on curcumin.

J Inorg Biochem 2019 Feb 6;191:94-111. Epub 2018 Nov 6.

Laboratory of Inorganic Chemistry and Advanced Materials, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

Curcumin is a natural product with a broad spectrum of beneficial properties relating to pharmaceutical applications, extending from traditional remedies to modern cosmetics. The biological activity of such pigments, however, is limited by their solubility and bioavailability, thereby necessitating new ways of achieving optimal tissue cellular response and efficacy as drugs. Metal ion complexation provides a significant route toward improvement of curcumin stability and biological activity, with vanadium being a representative such metal ion, amply encountered in biological systems and exhibiting exogenous bioactivity through potential pharmaceuticals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183036
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http://dx.doi.org/10.1016/j.jinorgbio.2018.10.010DOI Listing
February 2019
7 Reads

Metal-mediated base pairing in DNA involving the artificial nucleobase imidazole-4-carboxylate.

J Inorg Biochem 2019 Feb 6;191:85-93. Epub 2018 Nov 6.

Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstraße 28/30, 48149 Münster, Germany. Electronic address:

The use of imidazole-4-carboxylate (X) as an artificial nucleobase in metal-mediated base pairing is reported. Towards this end, the corresponding deoxyribonucleoside was synthesized and structurally characterized as its sodium salt (sodium 1,2-dideoxy-1-(4-carboxyimidazol-1-yl)-d-ribofuranose). The deoxyribonucleoside was incorporated into different DNA duplexes (parallel-stranded and antiparallel-stranded), and their Cu(II)- and Ag(I)-binding behavior was investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183050
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http://dx.doi.org/10.1016/j.jinorgbio.2018.10.013DOI Listing
February 2019
7 Reads

Multi-action Pt(IV) anticancer agents; do we understand how they work?

Authors:
Dan Gibson

J Inorg Biochem 2019 Feb 15;191:77-84. Epub 2018 Nov 15.

Institute for Drug Research, School of Pharmacy, The Hebrew University, Jerusalem, 91120, Israel. Electronic address:

Pt(IV) complexes act as prodrugs that are activated inside cancer cells releasing cytotoxic Pt(II) drugs such as cisplatin as well as two axial ligands. These ligands can be used to confer favorable pharmacological properties to the prodrug. They can be innocent spectators, targeting agents or bioactive moieties. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.008DOI Listing
February 2019
6 Reads

Interaction of amylin species with transition metals and membranes.

J Inorg Biochem 2019 Feb 10;191:69-76. Epub 2018 Nov 10.

King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science and Engineering (BESE), 23955-6900 Thuwal, Saudi Arabia. Electronic address:

Islet Amyloid Polypeptide (IAPP), also known as amylin, is a 37-amino-acid peptide hormone that is secreted by pancreatic islet β-cells. Amylin is complementary to insulin in regulating and maintaining blood glucose levels in the human body. The misfolding and aggregation of amylin is primarily associated with type 2 diabetes mellitus, which is classified as an amyloid disease. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.11.004DOI Listing
February 2019
11 Reads