5,614 results match your criteria Journal of inorganic biochemistry[Journal]


G-quadruplex and duplex DNA binding studies of novel Ruthenium(II) complexes containing ascididemin ligands.

J Inorg Biochem 2019 Apr 6;196:110681. Epub 2019 Apr 6.

Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, PR China. Electronic address:

In this paper, three new Ruthenium(II) polypyridyl complexes containing ascididemin (ASC) as main ligand have been synthesized and characterized. Their interactions with different G-quadruplex (Htelo, c-myc and c-kit) (Htelo: human telomeric DNA, c-myc: cellular-myelocytomatosis viral oncogene, c-kit: oncogene c-kit promoter sequences) and duplex (ds26) DNA sequences were comparatively studied with the free ligand ASC by a series of spectroscopic techniques including UV-vis (ultraviolet-visible) spectroscopy, FID (fluorescent intercalator displacement) assay, and FRET (fluorescence resonance energy transfer) melting assay. Molecular docking studies were also performed to support the binding mode of the compounds with G-quadruplex DNA. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.021DOI Listing

Cobalt(II) complexes with the non-steroidal anti-inflammatory drug diclofenac and nitrogen-donor ligands.

J Inorg Biochem 2019 Apr 5;196:110688. Epub 2019 Apr 5.

Laboratory of Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. Electronic address:

The interaction of the non-steroidal anti-inflammatory drug sodium diclofenac with CoCl in the absence or presence of the nitrogen-donor ligands 2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyridylamine, pyridine or imidazole resulted in the formation of six mononuclear Co(II) complexes. The complexes were characterized by diverse physicochemical and spectroscopic techniques and single-crystal X-ray crystallography revealing a monodentate or a bidentate chelating binding mode of the diclofenac ligands. The scavenging activity of the complexes was evaluated in vitro against the free radicals of 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl; the complexes present significant scavenging activity of ABTS and hydroxyl radicals. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.04.002DOI Listing

Inactivation of NikR from Helicobacter pylori by a bismuth drug.

J Inorg Biochem 2019 Apr 8;196:110685. Epub 2019 Apr 8.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, China, 510275. Electronic address:

The NikR protein is an essential DNA regulator of Helicobacter pylori, a human pathogen, which infects almost half of the world's population. Herein, we comprehensively characterized the interaction of a bismuth drug with Helicobacter pylori NikR. We show that Bi(III) can occupy the high-affinity Ni(II) site of NikR. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.025DOI Listing

Corrigendum to "Nuclear targeting terpyridine iron(II) complexes for cellular imaging and remarkable photocytotoxicity" [J. Inorg. Biochem. 116 (2012) 77-87].

J Inorg Biochem 2019 Apr 13:110692. Epub 2019 Apr 13.

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C. V. Raman Avenue, Bangalore 560012, Karnataka, India. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2019.04.006DOI Listing

Synthesis, crystal structures and insulin-like activity of three new oxidovanadium(V) complexes with aroylhydrazone ligand.

J Inorg Biochem 2019 Mar 29;196:110680. Epub 2019 Mar 29.

Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China. Electronic address:

Three new oxidovanadium(V) complexes were designed, synthesized and characterized by C, H, N elemental analysis, single crystal X-ray diffraction,UV/Vis and IR spectra. Complex 1: [VOLX] (HL = (E)-N'-(2-hydroxybenzylidene)-3-methbenzohydrazide, HX = ethylmaltol = 2-ethyl-3-hydroxy-4-pyrone), Complex 2: [VOL(CHO)(CHOH)], (HL = CHNO = (E)-N'-(2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide, CHOH = methanol), Complex 3: [VOLX] (HL = (E)-N'-(3-ethoxy-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide). The insulin-like activity of the three complexes was tested. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.020DOI Listing

Binary-ternary Cd(II)-(hydroxycarboxylic acid)-(aromatic chelator) systems exhibit in vitro cytotoxic selectivity in a tissue-specific manner.

J Inorg Biochem 2019 Feb 23;195:201-215. Epub 2019 Feb 23.

Laboratory of Inorganic Chemistry and Advanced Materials, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

Cadmium is a metallotoxin, amply encountered in the environment and derived through physical and anthropogenic activities. Its entry in various organisms leads through water and the food chain to humans, thereby inducing a plethora of pathophysiologies. Delineation of the interactive role of cadmium with physiological and physiologically relevant substrates, requires well-defined forms of cadmium arising from such interactions along with the ensuing chemical reactivity amounting to toxic manifestations and health aberrations. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.009DOI Listing
February 2019
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The crystal structure of the CopC protein from Pseudomonas fluorescens reveals amended classifications for the CopC protein family.

J Inorg Biochem 2019 Mar 21;195:194-200. Epub 2019 Mar 21.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3083, Australia. Electronic address:

The bacterial CopC family of proteins are periplasmic copper binding proteins that act in copper detoxification. These proteins contain Cu(I) and/or Cu(II) binding sites, with the family that binds Cu(II) only the most prevalent, based on sequence analyses. Here we present three crystal structures of the CopC protein from Pseudomonas fluorescens (Pf-CopC) that include the wild type protein bound to Cu(II) and two variant proteins, where Cu(II) coordinating ligands were mutated, in Cu-free states. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183075
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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.007DOI Listing
March 2019
2 Reads

Vanadocene complexes bearing N,N'-chelating ligands: Synthesis, structures and in vitro cytotoxic studies on the A549 lung adenocarcinoma cell line.

J Inorg Biochem 2019 Mar 22;195:182-193. Epub 2019 Mar 22.

Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic. Electronic address:

Ten new vanadocene complexes bearing N,N'-chelating ligands were prepared, characterized, and their cytotoxicity toward a panel of cancer cells was measured. Structures of four vanadocene compounds were determined by single crystal X-ray diffraction analysis. Complexes containing 1,2-bis(phenylimino)acenaphthene (bian) and 1,2-bis(4-methoxyphenylimino)acenaphthene (4-MeO-bian) exhibit higher cytotoxicity than those with dipyrido[3,2-a:2',3'-c]phenazine (dppz) and (E)-N-((pyridin-2-yl)methylene)benzenamine (pyma). Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.015DOI Listing
March 2019
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Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors.

J Inorg Biochem 2019 Mar 30;195:174-181. Epub 2019 Mar 30.

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. Electronic address:

In this report, we designed and synthesized a series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase kinase-1) inhibitory activity. Based on our previous report, the CoSBC exhibited high binding affinity with MEK1 protein. To further explore metal complexes as MEK1 inhibitors, a series of transition metals and ligands were employed to build a library of various metal Schiff base complexes. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.022DOI Listing

Mannich base Cu(II) complexes as biomimetic oxidative catalyst.

J Inorg Biochem 2019 Mar 30;195:164-173. Epub 2019 Mar 30.

Discipline of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Khandwa Road, Simrol, Indore 453552, India; Discipline of Biosciences and Biomedical Engineering, School of Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Indore 453552, India. Electronic address:

Galactose Oxidase (GOase) and catechol oxidase (COase) are the metalloenzymes of copper having monomeric and dimeric sites of coordination, respectively. This paper summarizes the results of our studies on the structural, spectral and catalytic properties of new mononuclear copper (II) complexes [CuL(OAc)] (1), and [CuL] (2), (HL = 2,4‑dichloro‑6‑{[(2'‑dimethyl‑aminoethyl)methylamino]methyl}‑phenol) which can mimic the functionalities of the metalloenzymes GOase and COase. The structure of the compounds has been elucidated by X-ray crystallography and the mimicked Cu(II) catalysts were further characterized by EPR. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.023DOI Listing
March 2019
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Silver(I) complexes with 4,7-phenanthroline efficient in rescuing the zebrafish embryos of lethal Candida albicans infection.

J Inorg Biochem 2019 Mar 23;195:149-163. Epub 2019 Mar 23.

Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia. Electronic address:

Five novel silver(I) complexes with 4,7-phenanthroline (4,7-phen), [Ag(NO-O)(4,7-phen-μ-N4,N7)] (1), [Ag(ClO-О)(4,7-phen-μ-N4,N7)] (2), [Ag(CFCOO-O)(4,7-phen-μ-N4,N7)] (3), [Ag(HO)(4,7-phen)](SbF) (4) and {[Ag(HO)(4,7-phen-μ-N4,N7)](BF)} (5) were synthesized, structurally elucidated and biologically evaluated. These complexes showed selectivity towards Candida spp. in comparison to the tested bacteria and effectively inhibited the growth of four different Candida species, particularly of C. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.017DOI Listing

Formation and stability of the mixed-chelator complexes of Sr, Mg, Ca, Ba, and Y in solution with bio-relevant chelators.

J Inorg Biochem 2019 Mar 22;195:141-148. Epub 2019 Mar 22.

Institute of Science and Engineering, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. Electronic address:

The formation and equilibria of Sr, Mg, Ca, Ba, and Y (M) complexes with a mixed-chelator comprising two biodegradable chelators (GLDA, L, 2-[bis(carboxymethyl)amino] pentanedioic acid; HIDS, L, 2-(1,2-dicarboxyethylamino)-3-hydroxy-butanedioic acid) in an aqueous matrix was evaluated. The potentiometric measurement results (ionic strength, 0.10 M; temperature, 25 ± 0. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.018DOI Listing

Pt(IV) hybrids containing a TDO inhibitor serve as potential anticancer immunomodulators.

J Inorg Biochem 2019 Feb 12;195:130-140. Epub 2019 Feb 12.

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189, China. Electronic address:

Tryptophan 2,3-dioxygenase (TDO), an immunosuppressive enzyme, can involve in immune evasion and tumor tolerance. TDO inhibitors can boost the efficacy of chemotherapeutics by promoting immunity. Herein, a strategy to introduce a TDO inhibitor into Pt(IV) complexes for reversing tumor immune suppression was adopted. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.004DOI Listing
February 2019

The essential metals for humans: a brief overview.

J Inorg Biochem 2019 Mar 22;195:120-129. Epub 2019 Mar 22.

Department of Life and Environmental Sciences, University of Cagliari, Italy.

The human body needs about 20 essential elements in order to function properly and among them, for certain, 10 are metal elements, though for every metal we do need, there is another one in our body we could do without it. Until about 1950 poor attention was given to the so-called "inorganic elements" and while researches on "organic elements" (C, N, O and H) and organic compounds were given high priority, studies on essential inorganic elements were left aside. Base on current knowledge it is ascertained today that metals such as Na, K, Mg, Ca, Fe, Mn, Co, Cu, Zn and Mo are essential elements for life and our body must have appropriate amounts of them. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183068
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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.013DOI Listing
March 2019
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Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology.

J Inorg Biochem 2019 Mar 23;195:111-119. Epub 2019 Mar 23.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Alpha lipoic acid (α-LA) and its reduced form dihydrolipoic acid (DHLA) have been historically considered as excellent anti-oxidants and oxidative stress scavengers. Upon oxidation with reactive oxygen species (ROS) and pro-oxidants, α-LA may be reconstituted from DHLA and other reduced forms. Oxidative stress is one of the fundamental causes of functional degeneration, autophagy and apoptosis leading to cytotoxicity and loss of cell survival, often due to exposure to xenobiotics, pollutants, heavy metals, and other environmental and endogenous toxicants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183049
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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.019DOI Listing
March 2019
1 Read

Zinc-oxaprozin compounds: Synthesis, structure and biological activity.

J Inorg Biochem 2019 Mar 21;195:101-110. Epub 2019 Mar 21.

Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. Electronic address:

Four novel zinc complexes, namely [Zn(oxa)(MeOH)] (1), [Zn(oxa)(HO)(bipy)]·MeOH·2.5HO (2·MeOH·2.5HO), [Zn(oxa)(bipyam)]·1. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.016DOI Listing

Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone.

J Inorg Biochem 2019 Feb 28;195:91-100. Epub 2019 Feb 28.

Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary. Electronic address:

Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η-CMe)(HO)]. Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η‑p‑cymene), Ru(η‑toluene) complexes were also studied. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.015DOI Listing
February 2019

Antigiardiasic activity of Cu(II) coordination compounds: Redox imbalance and membrane damage after a short exposure time.

J Inorg Biochem 2019 Mar 21;195:83-90. Epub 2019 Mar 21.

Facultad de Química, Universidad Nacional Autónoma de México, Avenida Universidad 3000, C.P. 04510 Ciudad de México, Mexico. Electronic address:

Giardiasis is a widespread illness that affects inhabitants of underdeveloped countries, being children and seniors the highest risk population. The several adverse effects produced by current therapies besides its increasing ineffectiveness due to the appearance of resistant strains evidence the urgent need for new therapeutic approaches. We present the antigiardiasic effect of eight Cu(II) coordination compounds, which belong to the family Casiopeínas. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.012DOI Listing
March 2019
1 Read

Phleomycin complex - Coordination mode and in vitro cleavage of DNA.

J Inorg Biochem 2019 Mar 21;195:71-82. Epub 2019 Mar 21.

Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland.

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is commonly used as a copper(II) complex. Therefore, it is important to study the metal ion binding process and to define the coordination mode. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.010DOI Listing

The hydrogen bonding network of coproheme in coproheme decarboxylase from Listeria monocytogenes: Effect on structure and catalysis.

J Inorg Biochem 2019 Mar 21;195:61-70. Epub 2019 Mar 21.

Dipartimento di Chimica "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, (Fi), Italy. Electronic address:

Coproheme decarboxylase (ChdC) catalyzes the oxidative decarboxylation of coproheme to heme b, i.e. the last step in the recently described coproporphyrin-dependent pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134193003
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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.009DOI Listing
March 2019
5 Reads

Studying the reactivity of "old" Cu(II) complexes for "novel" anticancer purposes.

J Inorg Biochem 2019 Mar 18;195:51-60. Epub 2019 Mar 18.

Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193-Cerdanyola del Vallès, Barcelona, Spain. Electronic address:

Reactive oxygen species (ROS) formation appears as one of the most promising pathways to induce cell death. The interesting Cu(II)/Cu(I) redox pair has been reported to biologically generate ROS and induce cell damage. Simple metal complexes, such as cisplatin, sometimes offer even better properties than others highly accurately synthesized, which imply considerable time and economical efforts. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.011DOI Listing

Structures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines.

J Inorg Biochem 2019 Mar 14;195:39-50. Epub 2019 Mar 14.

Department of Medicinal Biochemistry, Faculty of Medicine, University of Istinye, 34010 Istanbul, Turkey.

cis-[PtCl(sac)(PPhMe)] (1), cis-[PtCl(sac)(PPhMe)] (2), trans-[PtCl(sac)(PPhEt)] (3) and trans-[PtCl(sac)(PPhEt)] (4) complexes (sac = saccharinate) were synthesized and characterized by elemental analysis and spectroscopic methods. The structures of 2-4 were determined by X-ray single-crystal diffraction. The interaction of the complexes with DNA was studied various biochemical, biophysical and molecular docking methods. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.008DOI Listing
March 2019
2 Reads

Structural analysis of copper(I) interaction with amyloid β peptide.

J Inorg Biochem 2019 Mar 7;195:31-38. Epub 2019 Mar 7.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A. Moro 2, Siena, Italy. Electronic address:

The N-terminal fragment of Aβ (β = beta) peptide is able to bind essential transition metal ions like, copper, zinc and iron. Metal binding usually occurs via the imidazole nitrogens of the three His residues which play a key role in the coordination chemistry. Among all the investigated systems, the interaction between copper and Amyloid β assume a biological relevance because of the interplay between the two copper oxidation states, Cu(II) and Cu(I), and their involvement in redox reactions. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.006DOI Listing
March 2019
1 Read

Flexible vs. rigid bis(2-benzimidazolyl) ligands in Cu(II) complexes: Impact on redox chemistry and oxidative DNA cleavage activity.

J Inorg Biochem 2019 May 29;194:223-232. Epub 2019 Jan 29.

Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195 Berlin, Germany. Electronic address:

Cu(II) complexes of bis(2-benzimidazolyl) ligands connected by different linker moieties (disulfide, ethylene, ortho-phenylene) were applied in DNA cleavage reactions. Hydroxyl radicals and hydrogen peroxide were proven as reactive oxygen species (ROS) in a DNA quenching experiment. Thus, an oxidative DNA cleavage mechanism is suggested. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.016DOI Listing

What is pure hemozoin? A close look at the surface of the malaria pigment.

J Inorg Biochem 2019 May 16;194:214-222. Epub 2019 Feb 16.

Department of Mining and Materials Engineering, McGill University, Montreal, Quebec H3A 2B2, Canada. Electronic address:

The malaria parasite, Plasmodium spp., produces hemozoin (Hz) crystals as a by-product of hemoglobin digestion. Purification methods used to remove host or parasite products adsorbed on Hz surface lead to variable and undetermined residues. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.021DOI Listing

Modulating the antitumoral activity by the design of new platinum(II) compounds: Synthesis, characterization, DFT, ultrastructure and mechanistic studies.

J Inorg Biochem 2019 May 30;194:200-213. Epub 2019 Jan 30.

Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, 28013-602 Campos dos Goytacazes, RJ, Brazil. Electronic address:

The synthesis, physico-chemical characterization, Density functional theory (DFT) calculation and cytotoxicity against five human tumoral cell lines (THP-1, U937, Molt-4, Colo205 and H460) of four new platinum(II) coordination compounds are reported, i.e. [Pt(HL1)Cl]·HO (1), [Pt(HL2)Cl]·HO (2), [Pt(HL3)Cl]·HO (3) and [Pt(HL4)Cl]·HO (4). Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.016DOI Listing
May 2019
2 Reads

Stability constant determination of sulfur and selenium amino acids with Cu(II) and Fe(II).

J Inorg Biochem 2019 Mar 4;195:20-30. Epub 2019 Mar 4.

Department of Chemistry, Clemson University, Clemson, SC 29634-0973, USA. Electronic address:

Sulfur- and selenium-containing amino acids are of great biological importance, but their metal-binding properties with biologically-relevant metal ions are not well investigated. Stability constants of the methionine, selenomethionine, methylcysteine, and methylselenocysteine with Cu(II) and Fe(II) were determined by potentiometric titration. Stability constants of Cu(II) with these thio- and selenoether amino acids are in the range of 8. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.001DOI Listing
March 2019
2 Reads

ESI-TOF MS analysis of complexes formed between quercetin and five metal ions in hot water and a study into their DNA cleavage activity.

J Inorg Biochem 2019 Mar 4;195:13-19. Epub 2019 Mar 4.

Jiangxi Molecular Drug Design and Evaluation Key Laboratory, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, China.

Quercetin is a flavonoid compound widely found in vegetables, fruits, and medicinal plants. It has carbonyl and phenolic hydroxyl groups in its structure that can easily form complexes with metal ions. In this study, we reacted quercetin in water at 95 °C with five metal trace elements commonly found in plants, namely calcium, magnesium, zinc, iron(III), and copper. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.004DOI Listing
March 2019
3 Reads

Synthesis and encapsulation of V(IV,V) compounds in silica nanoparticles targeting development of antioxidant and antiradical nanomaterials.

J Inorg Biochem 2019 May 2;194:180-199. Epub 2019 Jan 2.

Laboratory of Inorganic Chemistry and Advanced Materials, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

The quest for effective treatments of oxidative stress has concentrated over the years on new nanomaterials with improved antioxidant and antiradical activity, thereby attracting broad research interest. In that regard, research efforts in our lab were launched to pursue such hybrid materials involving a) synthesis of silica gel matrices, b) evaluation of the suitability of atoxic matrices as potential carriers for the controlled release of V(IV)(VOSO), V(V)(NaVO) compounds and a newly synthesized heterometallic lithium-vanadium(IV,V) tetranuclear compound containing vanadium-bound hydroxycarboxylic 1,3-diamine-2-propanol-N,N,N',N'-tetraacetic acid (DPOT), and c) investigation of structural and textural properties of silica nanoparticles (NPs) by different and complementary characterization techniques, inquiring into the nature of the encapsulated vanadium species and their interaction with the siloxane matrix, collectively targeting novel antioxidant and antiradical nanomaterials biotechnology. The physicochemical characterization of the vanadium-loaded SiO NPs led to the formulation of optimized material configuration linked to the delivery of the encapsulated antioxidant-antiradical load. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183017
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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.005DOI Listing
May 2019
4 Reads

Increased ROS generation causes apoptosis-like death: Mechanistic insights into the anti-Leishmania activity of a potent ruthenium(II) complex.

J Inorg Biochem 2019 Mar 6;195:1-12. Epub 2019 Mar 6.

Laboratório de Bioquímica e Toxinas Animais, Instituto de Biotecnologia, Universidade Federal de Uberlândia, UFU, Uberlândia, MG, Brazil. Electronic address:

Some metallodrugs that exhibit interesting biological activity contain transition metals such as ruthenium, and have been extensively exploited because of their antiparasitic potential. In previous study, we reported the remarkable anti-Leishmania activity of precursor cis-[RuCl(dppm)], where dppm = bis(diphenylphosphino)methane, and new ruthenium(II) complexes, cis-[Ru(η-OCCH)(dppm)]PF (bbato), cis-[Ru(η-OCCHS)(dppm)]PF (mtbato) and cis-[Ru(η-OCCHO)(dppm)]PF (hmxbato) against some Leishmania species. In view of the promising activity of the hmxbato complex against Leishmania (Leishmania) amazonensis promastigotes, the present work investigated the possible parasite death mechanism involved in the action of this hmxbato and its precursor. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.005DOI Listing

Oligomerization of cytochrome c, myoglobin, and related heme proteins by 3D domain swapping.

Authors:
Shun Hirota

J Inorg Biochem 2019 May 3;194:170-179. Epub 2019 Mar 3.

Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan. Electronic address:

Oligomerization of heme proteins is useful for construction of new materials with cooperative and systematic functions; thus, diverse methods have been applied for construction of artificial heme protein oligomers. Three-dimensional (3D) domain swapping is a protein oligomerization phenomenon that exchanges the same domain or secondary structural element between molecules. 3D domain swapping was first reported in 1994; since then many proteins have been reported to domain swap. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.002DOI Listing

Interactions of acetamide and acrylamide with heme models: Synthesis, infrared spectra, and solid state molecular structures of five- and six-coordinate ferric porphyrin derivatives.

J Inorg Biochem 2019 May 4;194:160-169. Epub 2019 Mar 4.

Price Family Foundation Institute of Structural Biology, Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman 73019, OK, USA. Electronic address:

The amide functional group is a fundamental building block of proteins, but is also present in several industrial chemicals such as acetamide and acrylamide. Some acetamide derivatives are known to deplete cytoplasmic heme, and some acrylamide derivatives are known to cause porphyria and may activate soluble guanylyl cyclase through a heme-dependent mechanism. We have prepared a representative set of six-coordinate acetamide and acrylamide (L) complexes of iron porphyrins of the form [(por)Fe(L)]ClO (por = TPP (tetraphenylporphyrinato dianion), T(p-OMe)PP (tetrakis(p-methoxyphenyl)porphyrinato dianion)) in 76-83% yields. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.003DOI Listing

Synthesis, characterization and antibacterial activity of Zn(II) coordination polymer.

J Inorg Biochem 2019 May 27;194:153-159. Epub 2019 Feb 27.

School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. Electronic address:

In this study, the zinc(II)-based coordination polymer, [Zn(CPDA)(NO))](CPDA = 1,2-cyclopentanedicarboxylic acid) (1), had been successfully synthesized according to the hydrothermal method. Afterwards, 1 had been characterized by means of single crystal and power X-ray diffraction, elemental analysis, thermogravimetric analysis and infrared spectrum techniques. In addition, the antibacterial activities in vitro had been evaluated towards Escherichia coli (E. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183068
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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.014DOI Listing
May 2019
8 Reads

Anti-proliferative and antitumor activity of organotin(IV) compounds. An overview of the last decade and future perspectives.

J Inorg Biochem 2019 May 13;194:114-152. Epub 2019 Feb 13.

Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. Electronic address:

Organotins(IV) exhibit significant in vitro anti-proliferative activity, while the in vivo tests are encouraging. The recent reports on the anti-proliferative activity of organotin(IV) compounds are summarized in this review. The period covered by this work goes back to 2009 until late 2018, while the earlier ones, are included over the previous review of our group published by S. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.003DOI Listing

Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality: Structure, SOD-mimetic activity, interaction with albumin, DNA damage study and anticancer activity.

J Inorg Biochem 2019 May 23;194:97-113. Epub 2019 Feb 23.

Department of Physical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia; College of Science, King Saud University, Saudi Arabia. Electronic address:

Copper(II) complexes containing non-steroidal anti-inflammatory drugs (NSAIDs) have been the subject of many research papers and reviews. Here we report the synthesis, spectroscopic study and biological activity of novel mixed copper(II) complexes with NSAIDs: tolfenamic (tolf), mefenamic (mef) and flufenamic (fluf) acids and phenanthroline (phen): [Cu(tolf-O,O')(phen)] (1), [Cu(mef-O,O')(phen)] (2), [Cu(fluf-O,O')(phen)] (3). Complexes were characterized by X-ray analysis and EPR spectroscopy. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.010DOI Listing
May 2019
3 Reads

Palladium(II) complexes with salicylaldehyde ligands: Synthesis, characterization, structure, in vitro and in silico study of the interaction with calf-thymus DNA and albumins.

J Inorg Biochem 2019 May 24;194:85-96. Epub 2019 Feb 24.

Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki GR-54124, Greece. Electronic address:

The synthesis and characterization of four palladium(II) complexes with substituted salicylaldehydes (X-saloH) having the general formula [Pd(X-salo)] was undertaken. The complexes are formulated as [Pd(3-OCH-salo)] 1, [Pd(5-NO-salo)] 2, [Pd(5-Cl-salo)] 3, and [Pd(5-Br-salo)] 4. The structure of complex 1 was verified by single-crystal X-ray crystallography. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.013DOI Listing
May 2019
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Half-sandwich Ru(η-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity.

J Inorg Biochem 2019 May 23;194:74-84. Epub 2019 Feb 23.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. Electronic address:

Organometallic Ru(II)-arene complexes have emerged as potential alternatives to platinum appended agents due to their wide range of interesting features such as stability in solution and solid, significant activity, less toxicity and hydrophobic property of arene moiety, etc. Hence, a series of Ru(II)-p-cymene complexes, [(η-p-cymene)Ru(η-N,N-L1)Cl]Cl (1), [(η-p-cymene)Ru(η-N-L2)Cl] (2) and [(η-p-cymene)Ru(η-N-L3)Cl] (3) were prepared from pyrazole based ligands [2-(1H-pyrazol-3-yl)pyridine (L1), 3-(furan-2-yl)-1H-pyrazole (L2) and 3-(thiophen-2-yl)-1H-pyrazole (L3)], and [RuCl-(η-p-cymene)] dimer. The new Ru(II)-p-cymene complexes were well characterized by elemental analysis, and spectroscopic (FT-IR, UV-Visible, H NMR, C NMR and mass) and crystallographic methods. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.012DOI Listing

Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent.

J Inorg Biochem 2019 May 21;194:65-73. Epub 2019 Feb 21.

Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece. Electronic address:

This study aims at the further expansion of knowledge on the antimicrobial activities of the tetramic acid moiety and the effect of metal complexation. Complexes of the N-acetyl-3-acetyl-5-benzylidenetetramic acid with Mn, Co, Ni, Cu, Zn and Cd were synthesized and screened against 5 key ESKAPE pathogens (Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) and 2 fungi (Cryptococcus neoformans and Candida albicans). The cadmium complex was found to effectively inhibit the fungus Cryptococcus neoformans with minimum inhibitory concentration (MIC) of 8 μg/mL, with no human cell toxicity and hemolytic activity within the tested concentration range. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.008DOI Listing
May 2019
3 Reads

Anticancer activity and mechanism of bis-pyrimidine based dimetallic Ru(II)(η-p-cymene) complex in human non-small cell lung cancer via p53-dependent pathway.

J Inorg Biochem 2019 May 23;194:52-64. Epub 2019 Feb 23.

Center for Supramolecular Chemistry and Catalysis, Department of Chemistry, Shanghai University, Shanghai 200444, China; Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China. Electronic address:

Non-small cell lung cancer (NSCLC) is the most common cancer worldwide, which is related with poor prognosis and resistance to chemotherapy. Notably, ruthenium-based complexes have emerged as good alternative to the currently used platinum-based drugs for cancer therapy. In the present study, we synthesized a novel bis-pyrimidine based ligand 1,3-bis(2-methyl-6-(pyridin-2-yl)pyrimidin-4-yl)benzene (L) and used it in the synthesis of a dimetallic Ru(II) cymene complex [(Ru(η-p-cymene)Cl)(1,3-bis(2-methyl-6-(pyridin-2-yl)pyrimidin-4-yl)benzene)] (L-Ru). Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.019DOI Listing
May 2019
1 Read

Interaction of metal ions with tau protein. The case for a metal-mediated tau aggregation.

J Inorg Biochem 2019 May 14;194:44-51. Epub 2019 Feb 14.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada; Department of Physical and Environmental Science, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada. Electronic address:

Tau protein aggregation and its hyperphosphorylation play an important role in the pathogenesis of Alzheimer's disease. There is also considerable evidence for the accumulation of Fe, Cu, and Zn in the brain of Alzheimer's patients, although their involvement in the etiology of the disease remains unknown. Here, interactions of the 3d metal ions Fe, Cu, and Zn with the longest isoform of the human tau protein (htau40) are studied in detail. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183066
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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.007DOI Listing
May 2019
6 Reads

Development of a series of 4-hydroxycoumarin platinum(IV) hybrids as antitumor agents: Synthesis, biological evaluation and action mechanism investigation.

J Inorg Biochem 2019 May 23;194:34-43. Epub 2019 Feb 23.

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, PR China.

A series of new 4-hydroxycoumarin platinum(IV) complexes were designed, synthesized and evaluated as antitumor agents. All the title compounds display moderate to effective antitumor activities toward the tested cell lines and two prominent compounds were screened out with activities comparable to cisplatin and oxaliplatin. The mechanism investigation demonstrates that the platinum(IV) compounds could be reduced to bivalence and exert significant genotoxicity to tumor cells. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.011DOI Listing
May 2019
3.444 Impact Factor

Complex formation equilibria of polyamine ligands with copper(II) and zinc(II).

J Inorg Biochem 2019 May 18;194:26-33. Epub 2019 Feb 18.

Department of Inorganic Chemistry, Faculty of Pharmacy, Campus Cartuja, University of Granada, E-18071 Granada, Spain.

A comprehensive study of the protonation equilibria of a series of polyamine ligands along with their complex formation equilibria with Cu and Zn is reported in this work. The primary aim of this study has been the achievement of homogeneous thermodynamic data on these ligands, in order to evaluate their influence on the homeostatic equilibria of essential metal ions (Cu and Zn) in biological fluids. These polyamines are largely used as linkers in the building of chelating agents for iron overload. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.006DOI Listing
May 2019
2 Reads

Diclofenac conjugates with biocides through silver(I) ions (CoMeD's); Development of a reliable model for the prediction of anti-proliferation of NSAID's-silver formulations.

J Inorg Biochem 2019 May 17;194:7-18. Epub 2019 Feb 17.

Inorganic Chemistry Laboratory, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. Electronic address:

The conjugation of diclofenac (DICLH), a Non-Steroidal Anti-inflammatory Drug (NSAID), with biocides such as dimethyl sulfoxide (DMSO) and triphenylphosphine (TPP), through silver(I) ions, results into the chemical [Ag(DICL)(L)] (L = DMSO and n = 2, m = 2, k = infinite (1); L = TPP and n = 1, m = 2, k = 1 (2)). The compounds were characterized by m.p. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.020DOI Listing
May 2019
4 Reads

Design of ruthenium-albumin hydrogel for cancer therapeutics and luminescent imaging.

J Inorg Biochem 2019 May 10;194:19-25. Epub 2019 Feb 10.

Department of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, PR China. Electronic address:

Improving cell uptake of metal compounds has became an important goal in the field of metal-based anticancer agents. This may combat platinum resistance and side effects seen commonly in current anticancer chemotherapy regimes. Here, we explore a novel degradable ruthenium-albumin hydrogel, which shows strong luminescence for cell imaging and high selectivity for cancer cells versus non-cancer cells. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.002DOI Listing
May 2019
2 Reads

Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3'-diindolylmethane ligand.

J Inorg Biochem 2019 May 13;194:1-6. Epub 2019 Feb 13.

Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany.

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate(IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondrial damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.005DOI Listing

Polyoxomolybdates as α-glucosidase inhibitors: Kinetic and molecular modeling studies.

J Inorg Biochem 2019 Apr 8;193:173-179. Epub 2019 Feb 8.

College of Food and Biological Engineering, Jimei University, Xiamen 361021, PR China.

Noninsulin dependent diabetes mellitus is a serious global disease that is treated by inhibiting α-glucosidase to reduce the glucose content in the blood. Several incompletely satisfactory therapeutic drugs are already on the market. In this report, we showed that polyoxomolybdates based on Keggin-type architecture are promising candidates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183058
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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.001DOI Listing
April 2019
5 Reads
3.444 Impact Factor

Facile synthesis of novel carbon-dots/hemin nanoplatforms for synergistic photo-thermal and photo-dynamic therapies.

J Inorg Biochem 2019 Apr 1;193:166-172. Epub 2019 Feb 1.

School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, PR China. Electronic address:

Due to the traditional therapies of cancer inducing huge pains to patients, the non-invasive photo-guided therapies are attracting massive attentions of researchers. Herein, the intelligent-designed carbon-dots/hemin nanoplatforms (HCDs NPs) were developed, owning high-authority photo-therapy for cancer. The fluorescence resonance energy transfer (FRET) effect enhanced the photo-thermal ability of HCDs NPs, endowing the synthesized nanoplatforms with photo-dynamic property simultaneously. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.018DOI Listing

A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe, Al, Cu and Zn, and in vivo bioassays.

J Inorg Biochem 2019 Apr 6;193:152-165. Epub 2019 Feb 6.

Dipartimento di Chimica e Farmacia, Università di Sassari, Sassari, Italy.

This work presents the simple and low cost synthesis of a new tripodal ligand, in which three units of kojic acid are coupled to a tris(2-aminoethyl)amine (tren) backbone molecule. The protonation equilibria, together with the complex formation equilibria of this ligand with Fe, Al, Cu and Zn ions were studied. The complementary use of potentiometric, spectrophotometric and NMR techniques, and of Density Functional Theory (DFT) calculations, has allowed a thorough characterization of the different species involved in equilibrium. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.012DOI Listing
April 2019
2 Reads
3.444 Impact Factor

Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation and apoptosis in the rat.

J Inorg Biochem 2019 Apr 1;193:143-151. Epub 2019 Feb 1.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Aluminum (Al) causes hippocampal lesions by oxidative stress, which is widely accepted as the primary pathogenesis of Al neurotoxicity. Lycopene (LYC), a naturally carotenoid, has received extensive attention due to its antioxidant effect. In this study, the neuroprotective effects and mechanisms of LYC against aluminum chloride (AlCl)-induced hippocampal lesions were explored. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.017DOI Listing
April 2019
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A cisplatin-based platinum(IV) prodrug containing a glutathione s-transferase inhibitor to reverse cisplatin-resistance in non-small cell lung cancer.

J Inorg Biochem 2019 Apr 29;193:133-142. Epub 2019 Jan 29.

Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189, China. Electronic address:

A Pt(IV) prodrug of cisplatin containing a glutathione s-transferase (GSTs) inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX), complex 1, was designed and studied aiming to overcome cisplatin-resistance and reduce its toxicity by inhibiting GSTs overexpressed in cancer cells. The complex could be reduced to release its active Pt(II) species and axial ligand in the presence of ascorbic acid. In cytotoxicity study, complex 1 showed more potent anticancer activity than cisplatin and NBDHEX against all the tested cancer cells, especially toward cisplatin resistant A549/DDP cells with a resistance factor value of 0. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.01.014DOI Listing
April 2019
2 Reads