4,064,644 results match your criteria Journal of health & life sciences law[Journal]


PD-(L)1 Inhibitors Versus Chemotherapy Versus Their Combination in Front-line Treatment for NSCLC: An Indirect Comparison.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

We comprehensively compared the therapeutic effects and safety of PD-1/L1 antibodies (I), chemotherapy (C) or their combination (I+C) as first-line treatments for advanced NSCLC. Online databases were searched to identify RCTs. Survival outcomes and safety events were pooled by indirect treatment comparison. Read More

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http://dx.doi.org/10.1002/ijc.32366DOI Listing

Impact of diagnosis and therapy on cognitive function in urea cycle disorders.

Ann Neurol 2019 Apr 24. Epub 2019 Apr 24.

Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

Objective: Individuals with urea cycle disorders (UCDs) often present with intellectual and developmental disabilities. The major aim of this study was to evaluate the impact of diagnostic and therapeutic interventions on cognitive outcomes in UCDs.

Methods: This prospective, observational, multicenter study includes data from 503 individuals with UCDs who had comprehensive neurocognitive testing with a cumulative follow-up of 702 patient-years. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25492
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http://dx.doi.org/10.1002/ana.25492DOI Listing
April 2019
1 Read

Head and Neck Pain in Patients Presenting with Acute Aortic Dissection.

Aorta (Stamford) 2018 Dec 24;6(6):130-138. Epub 2019 Apr 24.

Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.

Background:  Head and neck pain is an atypical presentation of acute aortic dissection. Classic teaching associates this pain with proximal dissections, but this has not been extensively studied.

Methods:  Patients enrolled in the International Registry of Acute Aortic Dissection from January 1996 to March 2015 were included in this study. Read More

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http://dx.doi.org/10.1055/s-0039-18388DOI Listing
December 2018

Composer-Visual Cohort Analysis of Patient Outcomes.

Appl Clin Inform 2019 Mar 24;10(2):278-285. Epub 2019 Apr 24.

Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States.

Objective:  Visual cohort analysis utilizing electronic health record data has become an important tool in clinical assessment of patient outcomes. In this article, we introduce Composer, a visual analysis tool for orthopedic surgeons to compare changes in physical functions of a patient cohort following various spinal procedures. The goal of our project is to help researchers analyze outcomes of procedures and facilitate informed decision-making about treatment options between patient and clinician. Read More

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http://dx.doi.org/10.1055/s-0039-1687862DOI Listing

Laparoscopic Box Training with Four Different Modules in a Tertiary Education and Research Hospital, Ankara, Turkey.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Department of Obstetrics and Gynecology, University of Health Sciences, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1055/s-0039-1688411DOI Listing

Minimally Invasive Craniocervical Decompression for Chiari 1 Malformation: An Operative Technique.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Seoul St. Mary's Hospital, Seocho Gu, Seoul, Korea, Republic of.

Chiari malformation type 1 (CM-1) is an ectopia of the cerebellar tonsils below the foramen magnum that causes severe disability due to its neurologic symptoms. The treatment of choice for CM-1 is decompression of the craniovertebral junction (CVJ). In some patients only an extradural decompression by removing the atlanto-occipital ligament may be sufficient. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685
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http://dx.doi.org/10.1055/s-0039-1685DOI Listing
April 2019
4 Reads

The Low-Cost, Long-Term Indwelling Pleural Catheter (LunGO): An Inexpensive and Effective Alternative for the Management of Dyspnea Associated with Malignant Pleural Effusions.

Respiration 2019 Apr 24:1-6. Epub 2019 Apr 24.

Thoracic Surgeon at Hospital Santa Marcelina de Itaquera, São Paulo, Brazil.

Background: A malignant pleural effusion (MPE) in patients with cancer is evidence of the underlying disease progression, resulting in many symptoms, and may lead to hospitalization. The treatment options include talc pleurodesis (TP) or the implantation of an indwelling pleural catheter. The costs of the latter approach are often seen to be inhibitive for the Brazilian and other emerging markets' public health system. Read More

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http://dx.doi.org/10.1159/000498971DOI Listing
April 2019
1 Read

Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?

Respiration 2019 Apr 24:1-11. Epub 2019 Apr 24.

Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.

Background: Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support.

Objectives: The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. Read More

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http://dx.doi.org/10.1159/000498972DOI Listing

No Difference in Prevalence of Transmitted Drug Resistance between Injection Drug Users and Non-Injection Drug Users: A Cross-Sectional Study among Antiretroviral Treatment-Naïve HIV Patients.

Intervirology 2019 Apr 24:1-11. Epub 2019 Apr 24.

Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China,

Objectives: The epidemiological evidence is inconsistent about whether HIV-positive injection drug users (IDUs) are at higher risk of developing antiretroviral resistance than any other HIV-positive populations. This study aims to investigate and compare transmitted drug resistance (TDR) between IDUs and non-IDUs in Lingshan County, an HIV-hit region in Guangxi, China, where IDU and heterosexual transmission were the two dominant transmission routes and roughly equally contributed to the local HIV transmission.

Methods: A cross-sectional study was conducted among newly diagnosed and antiretroviral-treatment (ART)-naïve HIV-1 patients from Lingshan County. Read More

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https://www.karger.com/Article/FullText/499367
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http://dx.doi.org/10.1159/000499367DOI Listing
April 2019
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Implementing Accessibility Settings in Touchscreen Apps for People Living with Dementia.

Gerontology 2019 Apr 24:1-11. Epub 2019 Apr 24.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.

Background: Accessibility options within apps can enable customisation and improve usability. The consideration of accessibility for people living with dementia has not been explored but is necessary to prevent a "digital divide" in our society. This study set out to examine whether the introduction of accessibility settings for people with dementia in two mainstream gaming apps (Solitaire and Bubble Explode) could improve the user experience. Read More

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http://dx.doi.org/10.1159/000498885DOI Listing

Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study.

Int Arch Allergy Immunol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Augsburg, Germany,

Background: Psychosocial factors are supposed to play a central role in the development of allergic diseases. Associations with seasonal and perennial forms of allergies have not been investigated, yet.

Objectives: The aim of the study was to investigate the associations of psychosocial factors (social status, depression, generalized anxiety, psychosocial stress, Type-D personality) with seasonal, perennial, and other forms of allergies in adults. Read More

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https://www.karger.com/Article/FullText/499042
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http://dx.doi.org/10.1159/000499042DOI Listing
April 2019
1 Read

Dual-source photon counting detector CT with a tin filter: a phantom study on iodine quantification performance.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Mayo Clinic, Rochester, Minnesota, UNITED STATES.

Purpose: Photon counting detectors (PCD) can provide spectral information to enable iodine quantification through multi-energy imaging but performance is limited by current PCD technology. The purpose of this work is to evaluate iodine quantification in a phantom study using dual-source PCD-CT (DS-PCD-CT), and compare to single-source (SS)-PCD-CT and traditional DS energy integrating detector (EID)-based dual-energy CT.
 Materials and Methods: A multi-energy CT phantom with iodine inserts (0 to 15 mg/ml concentration) was imaged on a research SS-PCD-CT scanner (CTDIvol = 18 mGy). Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c34DOI Listing

Dosimetric response of fabricated Ge-doped optical fibres in computed tomography RQT beam quality X-ray beams.

J Radiol Prot 2019 Apr 24. Epub 2019 Apr 24.

Imaging, University Putra Malaysia, Department of Imaging, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Serdang, 43400, MALAYSIA.

Novel germanium (Ge)-doped silica glass fibres tailor-made in Malaysia are fast gaining recognition as potential media for thermoluminescence (TL) dosimetry, with active research ongoing into exploitation of their various beneficial characteristics. Investigation is made herein of the capability of these media for use in diagnostic imaging dosimetry, specifically at the radiation dose levels typically obtained in conduct of Computed Tomography (CT). As a first step within such efforts, there is need to investigate the performance of the fibres using tightly defined spectra, use being made of a Philips constant potential industrial X-Ray facility, Model MG165, located at the Malaysian Nuclear Agency Secondary Standards Dosimetry Lab (SSDL). Read More

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http://dx.doi.org/10.1088/1361-6498/ab1c16DOI Listing

Parameterizing and validating existing algorithms for identifying out-of-bed time using hip-worn accelerometer data from older women.

Physiol Meas 2019 Apr 24. Epub 2019 Apr 24.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, UNITED STATES.

Objective: To parameterize and validate two existing algorithms for identifying out-of-bed time using 24-hour hip-worn accelerometer data from older women. 
 
 Approach: Overall, 628 women (80±6 years old) wore ActiGraph GT3X+ accelerometers 24 hours/day for up to 7 days and concurrently completed sleep-logs. Trained staff used a validated visual analysis protocol to measure in-bed periods on accelerometer tracings (criterion). Read More

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http://iopscience.iop.org/article/10.1088/1361-6579/ab1c04
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http://dx.doi.org/10.1088/1361-6579/ab1c04DOI Listing
April 2019
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Performance comparison of depth-encoding detectors based on dual-ended readout and different SiPMs for high-resolution PET applications.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Biomedical Engineering, University of California - Davis, One Shields Avenue, Davis, California, 95616, UNITED STATES.

Silicon photomultipliers (SiPMs) are widely used in positron emission tomography (PET), however, SiPMs from different vendors vary in their performance characteristics. In addition, the specifications provided by the manufacturers are measured under different operating conditions and using different test setups, making it difficult to choose the optimal device for a specific application using the published specifications. In this work, we evaluated four state-of-the-art 8 × 8 arrays of ~ 3 mm × 3 mm SiPMs from SensL, KETEK, and Hamamatsu for high-resolution dual-ended readout detectors using the same experimental setup and procedures. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c37DOI Listing

A Comparison of Oral Hygiene Products and Professional Care: A six-week randomized clinical trial.

J Dent Hyg 2018 Oct;92(5):45-51

To investigate the anti-gingivitis efficacy of a novel oral hygiene routine consisting of a two-step stannous fluoride dentifrice and hydrogen peroxide whitening gel system, an interactive oscillating-rotating electric toothbrush, and expanded polytetrafluoroethylene floss. A total of 52 participants (n=52;mean age 35.8±11. Read More

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October 2018

Glucoregulatory activity of Vesiculin in insulin sensitive and resistant mice.

Peptides 2019 Apr 21. Epub 2019 Apr 21.

School of Biological Sciences, New Zealand; Maurice Wilkins Centre for Molecular BioDiscovery, Auckland, New Zealand; Centre for Advanced Discovery and Experimental Therapeutics, Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, and the School of Biomedicine, the Medical School, University of Manchester, Manchester M13 9WL, UK.

Pancreatic islet-derived peptide hormones play key roles in the maintenance of systemic energy homeostasis and glucose balance, and defects in their regulation are strongly implicated in the pathogenesis of obesity and diabetes. Peptides have also been used as lead compounds for therapeutics targeting metabolic disease. It is therefore important to understand the activity and function of islet hormones in both their target tissues and the whole organism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193004
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http://dx.doi.org/10.1016/j.peptides.2019.04.011DOI Listing
April 2019
3 Reads

Practical considerations for developmental thyroid toxicity assessments: What's working, what's not, and how can we do better?

Regul Toxicol Pharmacol 2019 Apr 21. Epub 2019 Apr 21.

BASF SE, Experimental Toxicology and Ecology, 67056, Ludwigshafen, Germany. Electronic address:

Thyroid hormones (THs; T3 and T4) play a role in development of cardiovascular, reproductive, immune and nervous systems. Thus, interpretation of TH changes from rodent studies (during pregnancy, in fetuses, neonates, and adults) is critical in hazard characterization and risk assessment. A roundtable session at the 2017 Society of Toxicology (SOT) meeting brought together academic, industry and government scientists to share knowledge and different perspectives on technical and data interpretation issues. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.04.010DOI Listing

Large-scale network interactions involved in dividing attention between the external environment and internal thoughts to pursue two distinct goals.

Neuroimage 2019 Apr 21. Epub 2019 Apr 21.

Department of Psychology, Harvard University, William James Hall, 33 Kirkland Street, Cambridge, MA, 02138, USA. Electronic address:

Previous research suggests that default-mode network (DMN) and dorsal attention network (DAN) are involved in internally- and externally-directed attention, respectively, through interactions with salience network (SN) and frontoparietal network (FPCN). Performing a task requiring external attention is often accompanied by a down-regulation of attention to internal thoughts, and vice-versa. In contrast, we often divide our attention between the external environment and internal thoughts to pursue distinct goals, yet virtually no prior research has examined how brain networks support this functionally critical neurocognitive process. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.054DOI Listing

Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity.

Mol Cell Endocrinol 2019 Apr 21. Epub 2019 Apr 21.

School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Perth, Western Australia, 6845, Australia. Electronic address:

Studies have reported that plasma glutamine is reduced in type 2 diabetes (T2D) patients. Glutamine supplementation improves glycaemic control, however the mechanisms are unclear. Here, we evaluated in vitro the pancreatic beta cell bioenergetic and insulin secretory responses to various levels of glutamine availability, or treatment in the presence of an inhibitor of intracellular glutamine metabolism. Read More

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http://dx.doi.org/10.1016/j.mce.2019.04.013DOI Listing

In Situ Modification of Tissue Stem and Progenitor Cell Genomes.

Cell Rep 2019 Apr;27(4):1254-1264.e7

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA; Joslin Diabetes Center, Boston, MA 02215, USA. Electronic address:

In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis and regeneration, is of particular interest. Here, we use a sensitive Cre/lox fluorescent reporter system to test the efficiency of genome modification following in vivo transduction by adeno-associated viruses (AAVs) in tissue stem and progenitor cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.105DOI Listing

Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain.

Cell Rep 2019 Apr;27(4):1073-1089.e5

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. Electronic address:

Oligodendrocyte progenitor cells (OPCs) are widely distributed cells of ramified morphology in adult brain that express PDGFRα and NG2. They retain mitotic activities in adulthood and contribute to oligodendrogenesis and myelin turnover; however, the regulatory mechanisms of their cell dynamics in adult brain largely remain unknown. Here, we found that global Pdgfra inactivation in adult mice rapidly led to elimination of OPCs due to synchronous maturation toward oligodendrocytes. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.084DOI Listing

Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Cell Rep 2019 Apr;27(4):1062-1072.e5

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193041
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http://dx.doi.org/10.1016/j.celrep.2019.03.079DOI Listing
April 2019
1 Read

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila.

Cell Rep 2019 Apr;27(4):1050-1061.e3

Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address:

The melanization response is an important defense mechanism in arthropods. This reaction is mediated by phenoloxidases (POs), which are activated by complex extracellular serine protease (SP) cascades. Here, we investigate the role of SPs in the melanization response using compound mutants in D. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.101DOI Listing

Contrasting Roles of Transcription Factors Spineless and EcR in the Highly Dynamic Chromatin Landscape of Butterfly Wing Metamorphosis.

Cell Rep 2019 Apr;27(4):1027-1038.e3

Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA.

Development requires highly coordinated changes in chromatin accessibility in order for proper gene regulation to occur. Here, we identify factors associated with major, discrete changes in chromatin accessibility during butterfly wing metamorphosis. By combining mRNA sequencing (mRNA-seq), assay for transposase-accessible chromatin using sequencing (ATAC-seq), and machine learning analysis of motifs, we show that distinct sets of transcription factors are predictive of chromatin opening at different developmental stages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193043
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http://dx.doi.org/10.1016/j.celrep.2019.03.092DOI Listing
April 2019
1 Read

The Distribution of Post-Void Residual (PVR) Volumes in People Seeking Care in the Symptoms of Lower Urinary Tract Dysfunction Network (LURN) Observational Cohort Study with Comparison to Asymptomatic Populations.

Urology 2019 Apr 21. Epub 2019 Apr 21.

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.

Objectives: To describe the distribution of post-void residual (PVR) volumes across patients with and without lower urinary tract symptoms (LUTS) and examine relationships between self-reported voiding symptoms, storage symptoms, and PVR.

Methods: PVR and demographic data were obtained from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) observational cohort study. Self-reported symptoms were collected using the American Urological Association Symptom Index (AUA-SI) and the LUTS Tool. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.069DOI Listing

The retinoic acid receptor (RAR) α-specific agonist Am80 (tamibarotene) and other RAR agonists potently inhibit hepatitis B virus transcription from cccDNA.

Antiviral Res 2019 Apr 21. Epub 2019 Apr 21.

University Hospital Heidelberg (Germany), Center for Infectious Diseases, Molecular Virology, Germany; German Center for Infection Research (DZIF), Partner Site Heidelberg, TTU Hepatitis, Germany. Electronic address:

Chronic infection with the human Hepatitis B virus (HBV) is a major global health problem. Hepatitis D virus (HDV) is a satellite of HBV that uses HBV envelope proteins for cell egress and entry. Using infection systems encoding the HBV/HDV receptor human sodium taurocholate co-transporting polypeptide (NTCP), we screened 1181 FDA-approved drugs applying markers for interference for HBV and HDV infection. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.04.009DOI Listing

Small-Molecule-Based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems.

Annu Rev Biochem 2019 Apr 24. Epub 2019 Apr 24.

Morningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong, Hong Kong, P. R. China; email: , , , ,

Reactive oxygen species (ROS) encompass a collection of intricately linked chemical entities characterized by individually distinct physicochemical properties and biological reactivities. Although excessive ROS generation is well known to underpin disease development, it has become increasingly evident that ROS also play central roles in redox regulation and normal physiology. A major challenge in uncovering the relevant biological mechanisms and deconvoluting the apparently paradoxical roles of distinct ROS in human health and disease lies in the selective and sensitive detection of these transient species in the complex biological milieu. Read More

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http://dx.doi.org/10.1146/annurev-biochem-013118-111754DOI Listing

Associations between self-generated strategy use and MET-Home performance in adults with stroke.

Neuropsychol Rehabil 2019 Apr 24:1-15. Epub 2019 Apr 24.

e School of Occupational Therapy , Texas Woman's University , Dallas , TX , USA.

Self-generated strategy use has substantial potential for improving community living outcomes in adults with impaired executive function after stroke. However, little is known about how self-generated strategies support task performance in people with post-stroke executive function impairments living in the community. We explored strategy use among home-dwelling persons with stroke and neurologically-healthy control participants during the Multiple Errands Test-Home Version (MET-Home), a context-specific assessment with evidence of ecological validity designed to examine how post-stroke executive dysfunction manifests during task performance in the home environment. Read More

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http://dx.doi.org/10.1080/09602011.2019.1601112DOI Listing

Hazardous Chemical Emergencies and Poisonings.

N Engl J Med 2019 04;380(17):1638-1655

From the Division of Emergency Medicine and Poison Control Center, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (F.M.H.); the Department of Homeland Security, Washington, DC (M.A.K.); and the Division of Medical Toxicology, Department of Emergency Medicine, University of Connecticut Health Center and Hartford Hospital, Hartford (C.A.M.).

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http://dx.doi.org/10.1056/NEJMra1504690DOI Listing

The VA MISSION Act - Creating a Center for Innovation within the VA.

N Engl J Med 2019 Apr;380(17):1592-1594

From the VA Puget Sound Healthcare System (A.R.) and the Department of Medicine, University of Washington School of Medicine (A.R., SDF., J.M.L.) - both in Seattle; and the Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia (J.M.L.).

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http://dx.doi.org/10.1056/NEJMp1815209DOI Listing

No Shortcuts to Safer Opioid Prescribing.

N Engl J Med 2019 Apr 24. Epub 2019 Apr 24.

From the Centers for Disease Control and Prevention, Atlanta (D.D., T.H.); and Oregon Health and Science University, Portland (R.C.).

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http://dx.doi.org/10.1056/NEJMp1904190DOI Listing

Facing the Fluoroquinolone Facts: Safety Concerns Continue to Emerge.

Authors:
Stacy Peters

S D Med 2019 Mar;72(3):136-138

College of Pharmacy and Allied Health Professions, South Dakota State University.

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American Indian Ethics of Health Care When Serving American Indian Patients in South Dakota.

S D Med 2019 Mar;72(3):123-126

Department of Neurosciences, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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The Patient As Team: American Indian Healthcare and the Transorganization - A Shout for Leadership.

S D Med 2019 Mar;72(3):114-118

Sanford Clinic - Infectious Disease, Sioux Falls, South Dakota.

American Indian health care in the state of South Dakota meets the definition of a humanitarian crisis and as such is being called a third-world country within its own borders. This dizzying challenge will require an out-ofthe-box but previously successful Transorganization, to address a problem which will never be solved by separate organizations operating in silos. It will also require visionary leadership to shine a permanent light on this conundrum, inviting all physicians and healthcare systems to join together as a team of teams, until this situation is transformed. Read More

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Perceived Weight Status, Disease Risk and Weight Loss Among Young Adults.

S D Med 2019 Mar;72(3):102-108

Health and Nutritional Sciences Department, South Dakota State University.

Introduction: Accurate perception of overweight status can influence weight management practices and may contribute to perceived risk of weight-related diseases. Understanding how weight perception impacts weight management and perceived risks in young adults is important, as it is during this time that individuals are forming lifestyle behaviors and likely not burdened by chronic disease.

Methods: Cross-sectional data from 86 young adults (18-25 years) were analyzed. Read More

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Mesenchymal Stem Cell Capping on ECM-Anchored Caspase Inhibitor-Loaded PLGA Microspheres for Intraperitoneal Injection in DSS-Induced Murine Colitis.

Small 2019 Apr 24:e1901269. Epub 2019 Apr 24.

College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.

Mesenchymal stem cells (MSCs) are considered as a promising alternative for the treatment of various inflammatory disorders. However, poor viability and engraftment of MSCs after transplantation are major hurdles in mesenchymal stem cell therapy. Extracellular matrix (ECM)-coated scaffolds provide better cell attachment and mechanical support for MSCs after transplantation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019012
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http://dx.doi.org/10.1002/smll.201901269DOI Listing
April 2019
1 Read

Heterozygosity mapping for human dominant trait variants.

Hum Mutat 2019 Apr 24. Epub 2019 Apr 24.

Laboratory of Statistical Genetics, Rockefeller University, New York, New York.

Homozygosity mapping is a well-known technique to identify runs of homozygous variants that are likely to harbor genes responsible for autosomal recessive disease, but a comparable method for autosomal dominant traits has been lacking. We developed an approach to map dominant disease genes based on heterozygosity frequencies of sequence variants in the immediate vicinity of a dominant trait. We demonstrate through theoretical analysis that DNA variants surrounding an inherited dominant disease variant tend to have increased heterozygosity compared with variants elsewhere in the genome. Read More

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http://dx.doi.org/10.1002/humu.23765DOI Listing

The Montreal Cognitive Assessment After Omission of Hearing-Dependent Subtests: Psychometrics and Clinical Recommendations.

J Am Geriatr Soc 2019 Apr 24. Epub 2019 Apr 24.

Department of Psychology, Concordia University, Montréal, Quebec, Canada.

Objectives: Hearing loss (HL) is the third most common chronic health condition in older adults, yet it is often undiagnosed and/or untreated. Given the association between HL and cognitive impairment, it is expected that many people undergoing cognitive screening may have HL. The Montreal Cognitive Assessment (MoCA) is a brief screening test that assesses a wide range of cognitive functions sensitive to Alzheimer's disease (AD) and mild cognitive impairment (MCI). Read More

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http://dx.doi.org/10.1111/jgs.15940DOI Listing

An approach for visualizing the spatial metabolome of an entire plant root system inspired by the Swiss-rolling technique.

J Mass Spectrom 2019 Apr 24. Epub 2019 Apr 24.

Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, 99352.

The spatial configuration and morphology of roots are commonly monitored for a better understanding of plant health and development. However, this approach provides minimal details about the biochemistry regulating the observable traits. Therefore, the ability to metabolically map the entire root structure would be of major value. Read More

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http://dx.doi.org/10.1002/jms.4363DOI Listing

Visual attention to alcohol labels: an exploratory eye-tracking experiment.

Adicciones 2019 Mar 29;0(0):1207. Epub 2019 Mar 29.

Universidad de Bristol Universidad de Granada.

Current alcohol labelling goes unnoticed by consumers. In addition, EU legislation does not obligate the alcohol industry to include any health warning labels on alcohol packagings. This study aims to explore how the size and design of alcohol by volume (ABV) labels, along with the alcohol strength presented on these labels, influence visual attention toward them. Read More

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http://dx.doi.org/10.20882/adicciones.1207DOI Listing

Alcohol use and risk factors for self-harm behavior in Spanish adolescents.

Adicciones 2019 Mar 29;0(0):1239. Epub 2019 Mar 29.

Universidad de Oviedo.

Self-harm behaviors in children and adolescents constitute an important public health problem with prevalence figures in the clinical population between 40 and 80%. The objectives of the study were to analyze and compare the Spanish sub-samples of two studies, SEYLE and WE-STAY to determine prevalence, self-harm patterns and factors associated with self-harm behaviors, notably the use of alcohol or drugs. The questionnaires used in both studies were the Global School Health Survey (GSHS), the Beck Depression Inventory (BDI-II), the Strengths and Difficulties Questionnaire (SDQ). Read More

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http://dx.doi.org/10.20882/adicciones.1239DOI Listing

Gender differences among cannabis self-cultivators in Spain.

Adicciones 2019 Mar 28;0(0):1142. Epub 2019 Mar 28.

Unidad de Psicología Forense. Universidade de Santiago de Compostela.

The increase in cannabis use coincides with the proliferation of small-scale cannabis cultivation. These crops facilitate substance availability and increased use. Some investigations have studied the characteristics of small-scale cultivators; however, it is not known whether their profiles differ by gender. Read More

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http://dx.doi.org/10.20882/adicciones.1142DOI Listing

Trends in tobacco use among adolescents in Spain (2002-2018).

Adicciones 2019 Mar 28;0(0):1111. Epub 2019 Mar 28.

Universidad de Sevilla.

Smoking is the single greatest preventable cause of death in the world today. Adolescence is the developmental period during which smoking is most commonly initiated and addiction is likely to happen. The aim of this study is to examine trends in tobacco use among school-aged adolescents in Spain from 2002 to 2018 by sex and age. Read More

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http://dx.doi.org/10.20882/adicciones.1111DOI Listing

Evolution of alcohol and tobacco consumption in young people in Spain, after the law 42/2010 against smoking: 2011-2014.

Adicciones 2019 Mar 28;0(0):1035. Epub 2019 Mar 28.

Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Universidad de Córdoba. Hospital Universitario Reina Sofía de Córdoba. Universidad Pontificia de Salamanca.

The objective of the study was to evaluate alcohol and tobacco consumption in young people in Spain, after Law 42/2010, during the interval of 2011-2014. The sample consisted of 3270 young people aged between 15 and 24 years who completed the National Survey of Health in Spain (ENSE) of 2011 and the European Survey of Health in Spain (EESE) of 2014. Variables: consumption, type of tobacco, attempts to quit smoking, consumption and type of alcoholic beverage, binge drinking, and sociodemographic variables. Read More

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http://dx.doi.org/10.20882/adicciones.1035DOI Listing

Correlates of hospitalizations in internal medicine divisions among Israeli adults of different ethnic groups with hypertension, diabetes and cardiovascular diseases.

PLoS One 2019 24;14(4):e0215639. Epub 2019 Apr 24.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.

Background: Disparities in non-communicable diseases (NCDs) may affect health care utilization. We compared the correlates of hospitalizations in internal medicine divisions, of adults with NCDs, between the main population groups in Israel.

Methods: A cross-sectional study was conducted among Jews (N = 17,952) and Arabs (N = 10,441) aged ≥40 years with diabetes, hypertension or cardiovascular diseases, utilizing the computerized database of the largest health maintenance organization in Israel. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215639PLOS

The complexity of the interaction between binge-eating and attention.

PLoS One 2019 24;14(4):e0215506. Epub 2019 Apr 24.

Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.

Objective: To investigate whether binge-eating in patients with eating disorders (EDs) is associated with attentional deficits.

Methods: We studied ED patients with binge-eating (n = 51), no binge-eating (n = 59) and controls (n = 58). ED patients were assessed following the stabilization of weight and ED pathology. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215506PLOS

Total cholesterol variability and risk of atrial fibrillation: A nationwide population-based cohort study.

PLoS One 2019 24;14(4):e0215687. Epub 2019 Apr 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: Long-term variability of cardiometabolic risk factors have been suggested as the risk factors for cardiovascular disease and mortality. However, the effect of long-term variability of total cholesterol (TC) on incident atrial fibrillation (AF) has not been examined.

Methods And Findings: We explored whether visit-to-visit TC variability are associated with the risk of incident AF in 160,165 Korean adults, using the population-based Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) database, over a median duration of 8. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215687PLOS
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