338 results match your criteria Journal of gastric cancer[Journal]


Long-term Survival after Repeated Local Therapy and Salvage Chemotherapy for Recurrent Metastases from Gastric Cancer: a Case Report and Literature Review.

J Gastric Cancer 2018 Sep 22;18(3):305-312. Epub 2018 Aug 22.

Department of Surgery, Chungbuk National University Hospital, Cheongju, Korea.

We report a rare case of long-term survival in a patient who received local therapy and salvage chemotherapy for recurrent metastases, along with a literature review. A 65-year-old male patient underwent subtotal gastrectomy for advanced gastric adenocarcinoma. Six months after gastrectomy, 2 metastatic intra-abdominal lymph node enlargements were detected, which were treated with radiotherapy. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5230/jgc.2018.18
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http://dx.doi.org/10.5230/jgc.2018.18.e26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160522PMC
September 2018
4 Reads

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy as Treatment Options for Peritoneal Metastasis of Advanced Gastric Cancer.

J Gastric Cancer 2018 Sep 27;18(3):296-304. Epub 2018 Sep 27.

Department of Surgery, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea.

Purpose: This study aimed to examine the outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis (PM) of advanced gastric cancer (AGC).

Materials And Methods: Between May 2015 and June 2017, 38 CRS and HIPEC procedures were performed in patients with PM of AGC at the Dankook University Hospital. We prospectively collected and analyzed data regarding PM grade, morbidity and mortality rates, and short-term follow-up results (median, 13. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5230/jgc.2018.18
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http://dx.doi.org/10.5230/jgc.2018.18.e32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160528PMC
September 2018
6 Reads

Safety of Laparoscopic Radical Gastrectomy in Gastric Cancer Patients with End-Stage Renal Disease.

J Gastric Cancer 2018 Sep 13;18(3):287-295. Epub 2018 Sep 13.

Department of Surgery, The Catholic University of Korea St. Paul's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: The surgical outcomes of end-stage renal disease (ESRD) patients undergoing radical gastrectomy for gastric cancer were inferior compared with those of non-ESRD patients. This study aimed to evaluate the short- and long-term surgical outcomes of ESRD patients undergoing laparoscopic gastrectomy (LG) and open gastrectomy (OG) for gastric cancer.

Materials And Methods: Between 2004 and 2014, 38 patients (OG: 21 patients, LG: 17 patients) with ESRD underwent gastrectomy for gastric cancer. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160531PMC
September 2018
1 Read

The Impact of Preoperative Low Body Mass Index on Postoperative Complications and Long-term Survival Outcomes in Gastric Cancer Patients.

J Gastric Cancer 2018 Sep 14;18(3):274-286. Epub 2018 Sep 14.

Department of Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.

Purpose: The aim of this study was to investigate the impact of preoperative low body mass index (BMI) on both the short- and long-term outcomes in patients with gastric cancer.

Materials And Methods: A total of 510 patients with gastric cancer were divided into the following 3 groups: low BMI group (≤18.5 kg/m, n=51), normal BMI group (18. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160530PMC
September 2018
1 Read

Who Can Perform Adjuvant Chemotherapy Treatment for Gastric Cancer? A Multicenter Retrospective Overview of the Current Status in Korea.

J Gastric Cancer 2018 Sep 7;18(3):264-273. Epub 2018 Sep 7.

Department of Surgery, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.

Purpose: To investigate the current status of adjuvant chemotherapy (AC) regimens in Korea and the difference in efficacy of AC administered by surgical and medical oncologists in patients with stage II or III gastric cancers.

Materials And Methods: We performed a retrospective observational study among 1,049 patients who underwent curative resection and received AC for stage II and III gastric cancers between February 2012 and December 2013 at 29 tertiary referral university hospitals in Korea. To minimize the influence of potential confounders on selection bias, propensity score matching (PSM) was used based on binary logistic regression analysis. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160523PMC
September 2018
2 Reads

Impact of Various Types of Comorbidities on the Outcomes of Laparoscopic Total Gastrectomy in Patients with Gastric Carcinoma.

J Gastric Cancer 2018 Sep 10;18(3):253-263. Epub 2018 Sep 10.

Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Purpose: With increasing life expectancy, the presence of comorbidities has become a major concern in elderly patients who require surgery. However, little is known about the impact of different comorbidities on the outcomes of laparoscopic total gastrectomy (LTG). In this study, we investigated the impact of comorbidities on postoperative complications in patients undergoing LTG for gastric carcinoma. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5230/jgc.2018.18
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http://dx.doi.org/10.5230/jgc.2018.18.e27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160524PMC
September 2018
6 Reads

Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer.

J Gastric Cancer 2018 Sep 5;18(3):242-252. Epub 2018 Sep 5.

Department of Surgery, Mercy University Hospital, Cork, Ireland.

Purpose: Surgical resection for gastric adenocarcinoma is associated with significant post-operative morbidity and mortality. The aim of this study was to assess the prognostic significance of sarcopenia in patients undergoing resection for gastric adenocarcinoma with respect to post-operative morbidity and survival.

Materials And Methods: A retrospective analysis was conducted on a cohort of consecutive patients who underwent surgical resection for gastric adenocarcinoma between 2008 and 2014. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160525PMC
September 2018
2 Reads

Enhanced Recovery after Surgery for Gastric Cancer Patients Improves Clinical Outcomes at a US Cancer Center.

J Gastric Cancer 2018 Sep 16;18(3):230-241. Epub 2018 Aug 16.

Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

Purpose: Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GC-ERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERAS protocol at a National Comprehensive Cancer Center in the United States. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160527PMC
September 2018
1 Read

Preoperative Nodal F-FDG Avidity Rather than Primary Tumor Avidity Determines the Prognosis of Patients with Advanced Gastric Cancer.

J Gastric Cancer 2018 Sep 10;18(3):218-229. Epub 2018 Aug 10.

Department of Nuclear Medicine, Korea University Anam Hospital, Seoul, Korea.

Purpose: This study investigated whether the metabolic avidity of primary tumors and/or metastatic lymph nodes (LNs) measured by F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) was related to survival after surgery in patients with advanced gastric cancer (AGC).

Materials And Methods: One hundred sixty-eight patients with AGC who underwent preoperative F-FDG PET/CT and curative resection were included. The F-FDG avidity of the primary gastric tumor and LNs was determined quantitatively and qualitatively. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160526PMC
September 2018
5 Reads

Surgical Treatment of Gastroesophageal Junction Cancer.

J Gastric Cancer 2018 Sep 7;18(3):209-217. Epub 2018 Sep 7.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Although the incidence of gastroesophageal junction (GEJ) adenocarcinoma has been increasing worldwide, no standardized surgical strategy for its treatment has been established. This study aimed to provide an update on the surgical treatment of GEJ adenocarcinoma by reviewing previous reports and propose recommended surgical approaches. The Siewert classification is widely used for determining which surgical procedure is used, because previous studies have shown that the pattern of lymph node (LN) metastasis depends on tumor location. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5230/jgc.2018.18
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http://dx.doi.org/10.5230/jgc.2018.18.e28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160529PMC
September 2018
9 Reads

Erratum: Is Lymph Node Size a Reliable Factor for Estimating Lymph Node Metastasis in Early Gastric Cancer?

J Gastric Cancer 2018 Jun 2;18(2):208. Epub 2018 May 2.

Department of Surgery, The Catholic University of Korea Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

[This corrects the article on p. 20 in vol. 18, PMID: 29629217. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026710PMC

Multiregion Comprehensive Genomic Profiling of a Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Trilineage Differentiation.

J Gastric Cancer 2018 Jun 11;18(2):200-207. Epub 2018 Jun 11.

Department of Medicine, Stony Brook University Hospital, Stony Brook, NY, USA.

Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) are a group of rare tumors previously known as mixed adenoneuroendocrine carcinomas (MANECs). The neuroendocrine component is high-grade and may consist of small-cell carcinoma or large-cell neuroendocrine carcinoma. The nonneuroendocrine component may consist of adenocarcinoma or squamous cell carcinoma. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026709PMC
June 2018
8 Reads

Long-Term Nutritional Outcomes of Near-Total Gastrectomy in Gastric Cancer Treatment: a Comparison with Total Gastrectomy Using Propensity Score Matching Analysis.

J Gastric Cancer 2018 Jun 28;18(2):189-199. Epub 2018 Jun 28.

Division of Gastrointestinal Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: This study sought to examine whether near total gastrectomy (nTG) confers a long-term nutritional benefit when compared with total gastrectomy (TG) for the treatment of gastric cancer.

Materials And Methods: Patients who underwent nTG or TG for gastric cancer were included (n=570). Using the 1:2 matched propensity score, 25 patients from the nTG group and 50 patients from the TG group were compared retrospectively for oncologic outcomes, including long-term survival and nutritional status. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026712PMC
June 2018
9 Reads

Learning Curve of Pure Single-Port Laparoscopic Distal Gastrectomy for Gastric Cancer.

J Gastric Cancer 2018 Jun 28;18(2):182-188. Epub 2018 Jun 28.

Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: Despite the fact that there are several reports of single-port laparoscopic distal gastrectomy (SPDG), no analysis of its learning curve has been described in the literature. The aim of this study was to investigate the favorable factors for SPDG and to analyze the learning curve of SPDG.

Materials And Methods: A total of 125 cases of SPDG performed from November 2011 to December 2015 were enrolled. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026715PMC

Transition from Conventional to Reduced-Port Laparoscopic Gastrectomy to Treat Gastric Carcinoma: a Single Surgeon's Experience from a Small-Volume Center.

J Gastric Cancer 2018 Jun 27;18(2):172-181. Epub 2018 Jun 27.

Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.

Purpose: This study aimed to evaluate the surgical outcomes and investigate the feasibility of reduced-port laparoscopic gastrectomy using learning curve analysis in a small-volume center.

Materials And Methods: We reviewed 269 patients who underwent laparoscopic distal gastrectomy (LDG) for gastric carcinoma between 2012 and 2017. Among them, 159 patients underwent reduced-port laparoscopic gastrectomy. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026708PMC
June 2018
3 Reads

Assessment of the Completeness of Lymph Node Dissection Using Near-infrared Imaging with Indocyanine Green in Laparoscopic Gastrectomy for Gastric Cancer.

J Gastric Cancer 2018 Jun 28;18(2):161-171. Epub 2018 Jun 28.

Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: This study assessed the feasibility of near-infrared (NIR) imaging with indocyanine green (ICG) in investigating the completeness of laparoscopic lymph node (LN) dissection for gastric cancer.

Materials And Methods: Patients scheduled for laparoscopic gastrectomy for treating gastric cancer were enrolled in the study. After intraoperative submucosal ICG injection (0. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026716PMC
June 2018
7 Reads

Feasibility and Safety of Totally Laparoscopic Radical Gastrectomy for Advanced Gastric Cancer: Comparison with Early Gastric Cancer.

J Gastric Cancer 2018 Jun 22;18(2):152-160. Epub 2018 Jun 22.

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Totally laparoscopic gastrectomy (TLG) for advanced gastric cancer (AGC) is a technically and oncologically challenging procedure for surgeons. This study aimed to compare the oncologic feasibility and technical safety of TLG for AGC versus early gastric cancer (EGC).

Materials And Methods: Between 2011 and 2016, 535 patients (EGC, 375; AGC, 160) underwent curative TLG for gastric cancer. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026707PMC
June 2018
7 Reads

Modification of the TNM Staging System for Stage II/III Gastric Cancer Based on a Prognostic Single Patient Classifier Algorithm.

J Gastric Cancer 2018 Jun 31;18(2):142-151. Epub 2018 May 31.

Department of Surgery, Yonsei University Health System, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The modification of the cancer classification system aimed to improve the classical anatomy-based tumor, node, metastasis (TNM) staging by considering tumor biology, which is associated with patient prognosis, because such information provides additional precision and flexibility.

Materials And Methods: We previously developed an mRNA expression-based single patient classifier (SPC) algorithm that could predict the prognosis of patients with stage II/III gastric cancer. We also validated its utilization in clinical settings. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026714PMC
June 2018
6 Reads

Pancreatic Compression during Lymph Node Dissection in Laparoscopic Gastrectomy: Possible Cause of Pancreatic Leakage.

J Gastric Cancer 2018 Jun 5;18(2):134-141. Epub 2018 Jun 5.

Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Purpose: Postoperative pancreatic fistula is a serious and fatal complication of gastrectomy for gastric cancer. Blunt trauma to the parenchyma of the pancreas can result from an assistant's forceps compressing and retracting the pancreas, which in turn may result in pancreatic juice leakage. However, no published studies have focused on blunt trauma to the pancreas during laparoscopic surgery. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026711PMC
June 2018
3 Reads

Feasibility and Effects of a Postoperative Recovery Exercise Program Developed Specifically for Gastric Cancer Patients (PREP-GC) Undergoing Minimally Invasive Gastrectomy.

J Gastric Cancer 2018 Jun 25;18(2):118-133. Epub 2018 Apr 25.

Department of Surgery, Graduate School, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Exercise intervention after surgery has been found to improve physical fitness and quality of life (QOL). The purpose of this study was to investigate the feasibility and effects of a postoperative recovery exercise program developed specifically for gastric cancer patients (PREP-GC) undergoing minimally invasive gastrectomy.

Materials And Methods: Twenty-four patients treated surgically for early gastric cancer were enrolled in the PREP-GC. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026706PMC
June 2018
10 Reads

Role of Laparoscopic Gastrectomy in Very Elderly Patients with Gastric Cancer Who Have Outlived the Average Lifespan.

J Gastric Cancer 2018 Jun 24;18(2):109-117. Epub 2018 Apr 24.

Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: This study aimed to investigate the outcomes of laparoscopic gastrectomy in very elderly patients with gastric cancer, who have outlived the average lifespan of the Korean population (men: ≥77 years, women: ≥84 years).

Materials And Methods: Between 2004 and 2015, 836 patients with gastric cancer underwent a laparoscopic gastrectomy. They were divided into the elderly group (EldG) and non-elderly group (nEldG). Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026713PMC
June 2018
27 Reads

IgG4-related Disease in the Stomach which Was Confused with Gastrointestinal Stromal Tumor (GIST): Two Case Reports and Review of the Literature.

J Gastric Cancer 2018 Mar 28;18(1):99-107. Epub 2018 Mar 28.

Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory disorder characterized by specific pathological findings and elevated serum IgG4 level. IgG4-RD in the stomach is rare, and occasionally diagnosed as gastric subepithelial tumor (SET) by endoscopy or computed tomography scan. Two female patients in the age group of 40-50 years were diagnosed with 4 cm sized gastric SET. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881015PMC
March 2018
7 Reads

Successful Robotic Gastrectomy Does Not Require Extensive Laparoscopic Experience.

J Gastric Cancer 2018 Mar 29;18(1):90-98. Epub 2018 Mar 29.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: We evaluated the learning curve and short-term surgical outcomes of robot-assisted distal gastrectomy (RADG) performed by a single surgeon experienced in open, but not laparoscopic, gastrectomy. We aimed to verify the feasibility of performing RADG without extensive laparoscopic experience.

Materials And Methods: Between July 2012 and December 2016, 60 RADG procedures were performed by a single surgeon using the da Vinci Surgical System (Intuitive Surgical). Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881014PMC
March 2018
6 Reads

Early Detection is Important to Reduce the Economic Burden of Gastric Cancer.

J Gastric Cancer 2018 Mar 26;18(1):82-89. Epub 2018 Mar 26.

Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Early detection of gastric cancer is important to improve prognosis. Early detection enables local treatment, such as endoscopic submucosal dissection (ESD). Therefore, we investigated whether early detection of gastric cancer could reduce healthcare costs by comparison according to stage and treatment modalities. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881013PMC
March 2018
14 Reads

Survival Benefit of Perioperative Chemotherapy in Patients with Locally Advanced Gastric Cancer: a Propensity Score Matched Analysis.

J Gastric Cancer 2018 Mar 30;18(1):69-81. Epub 2018 Mar 30.

Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Purpose: It has been reported that the survival of patients with locally advanced gastric cancer (LAGC) is better in East Asia countries than in developed western countries; however, the prognosis of LAGC remains poor. This study aimed to evaluate the effects of perioperative chemotherapy on the long-term survival of East Asia patients with LAGC.

Materials And Methods: From October 2006 through August 2008, 43 patients with LAGC received perioperative S-1 combined with weekly docetaxel in a phase II study (neoadjuvant group). Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881012PMC
March 2018
13 Reads

Effect of Early Adjuvant Chemotherapy on Survival of Advanced Gastric Cancer Patients: a Propensity Score-matched Analysis.

J Gastric Cancer 2018 Mar 20;18(1):58-68. Epub 2018 Mar 20.

Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Purpose: Generally, adjuvant chemotherapy (AC) should be initiated as soon as possible after surgery to eradicate microscopic cancer cells. In this study, we investigated the effect of early AC on the survival of stage II/III gastric cancer patients.

Materials And Methods: Four hundred sixty patients who received AC (S-1 or XELOX) for pathologic stage II/III gastric cancer at Seoul National University Bundang Hospital between January 2008 and December 2014 were included. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881011PMC
March 2018
25 Reads

The Prognostic Significance of Compliance with Postoperative Adjuvant Chemotherapy in Patients with Stage III Gastric Cancer: an Observational Study.

J Gastric Cancer 2018 Mar 14;18(1):48-57. Epub 2018 Mar 14.

Department of Surgery, Hanyang University Seoul Hospital, Hanyang University School of Medicine, Seoul, Korea.

Purpose: Postoperative adjuvant chemotherapy is usually prescribed to improve the survival of patients with advanced gastric cancer who undergo curative surgery. This study was designed to determine the impact that the degree of compliance with chemotherapy has on the prognosis of patients with gastric cancer.

Materials And Methods: Among 252 patients with stage III gastric cancer who underwent curative surgery between July 2004 and December 2014, 85 patients were postoperatively treated with S-1, the oral fluoropyrimidine derivative, 23 received no chemotherapy, and 144 received other regimens. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881010PMC
March 2018
2 Reads

Novel Endoscopic Stent for Anastomotic Leaks after Total Gastrectomy Using an Anchoring Thread and Fully Covering Thick Membrane: Prevention of Embedding and Migration.

J Gastric Cancer 2018 Mar 20;18(1):37-47. Epub 2018 Feb 20.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Purpose: The endoscopic management of a fully covered self-expandable metal stent (SEMS) has been suggested for the primary treatment of patients with anastomotic leaks after total gastrectomy. Embedded stents due to tissue ingrowth and migration are the main obstacles in endoscopic stent management.

Materials And Methods: The effectiveness and safety of endoscopic management were evaluated for anastomotic leaks when using a benign fully covered SEMS with an anchoring thread and thick silicone covering the membrane to prevent stent embedding and migration. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881009PMC
March 2018
5 Reads

Safety of Laparoscopic Sentinel Basin Dissection in Patients with Gastric Cancer: an Analysis from the SENORITA Prospective Multicenter Quality Control Trial.

J Gastric Cancer 2018 Mar 26;18(1):30-36. Epub 2018 Mar 26.

Center of Gastric Cancer, National Cancer Center, Goyang, Korea.

Purpose: We investigated complications after laparoscopic sentinel basin dissection (SBD) for patients with gastric cancer who were enrolled in a quality control study, prior to the phase III trial of sentinel lymph node navigation surgery (SNNS).

Materials And Methods: We analyzed prospective data from a Korean multicenter prerequisite quality control trial of laparoscopic SBD for gastric cancer and assessed procedure-related and surgical complications. All complications were classified according to the Clavien-Dindo Classification (CDC) system and were compared with the results of the previously published SNNS trial. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881008PMC
March 2018
7 Reads

Is Lymph Node Size a Reliable Factor for Estimating Lymph Node Metastasis in Early Gastric Cancer?

J Gastric Cancer 2018 Mar 12;18(1):20-29. Epub 2017 Dec 12.

Department of Surgery, The Catholic University of Korea Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: Pre-operative lymph node (LN) size is a valuable parameter for determining treatment strategy for gastric cancer. However, a correlation between LN size and metastasis has not been established.

Materials And Methods: Thirty-six LN-positive (LNP) and matched 36 LN-negative (LNN) patients were included, and pathology slides of the LNs of these patients were reviewed. Read More

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http://dx.doi.org/10.5230/jgc.2018.18.e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881007PMC
March 2018
2 Reads

Novel Systemic Therapies for Advanced Gastric Cancer.

J Gastric Cancer 2018 Mar 14;18(1):1-19. Epub 2018 Mar 14.

Division of Oncology/Hematology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.

Gastric cancer (GC) is the second leading cause of cancer mortality and the fourth most commonly diagnosed malignant diseases. While continued efforts have been focused on GC treatment, the introduction of trastuzumab marked the beginning of a new era of target-specific treatments. Considering the diversity of mutations in GC, satisfactory results obtained from various target-specific therapies were expected, yet most of them were unsuccessful in controlled clinical trials. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5230/jgc.2018.18
Publisher Site
http://dx.doi.org/10.5230/jgc.2018.18.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881006PMC
March 2018
14 Reads

Potential Utility of FDG PET-CT as a Non-invasive Tool for Monitoring Local Immune Responses.

J Gastric Cancer 2017 Dec 28;17(4):384-393. Epub 2017 Dec 28.

Department of Surgery, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.

Purpose: The tumor microenvironment is known to be associated with the metabolic activity of cancer cells and local immune reactions. We hypothesized that glucose metabolism measured by 2-deoxy-2-(F)fluoro-D-glucose (F-FDG) positron emission tomography (PET)-computed tomography (CT) (F-FDG PET-CT) would be associated with local immune responses evaluated according to the presence of tumor infiltrating lymphocytes (TILs).

Materials And Methods: We retrospectively reviewed 56 patients who underwent F-FDG PET-CT prior to gastrectomy. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746659PMC
December 2017
4 Reads

Clinical Outcomes of Endoscopic Hemostasis for Bleeding in Patients with Unresectable Advanced Gastric Cancer.

J Gastric Cancer 2017 Dec 27;17(4):374-383. Epub 2017 Dec 27.

Division of Gastroenterology, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Bleeding is one of the most serious complications of advanced gastric cancer (AGC) and is associated with a poor prognosis. This study aimed to evaluate the clinical outcomes of endoscopic hemostasis for bleeding in patients with unresectable AGC.

Materials And Methods: This study included 106 patients with bleeding associated with gastric cancer who had undergone endoscopic hemostasis between January 2010 and December 2013. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746658PMC
December 2017
10 Reads

Clinicopathological Significance of Large Tumor Suppressor () Expression in Gastric Cancer.

J Gastric Cancer 2017 Dec 26;17(4):363-373. Epub 2017 Dec 26.

Department of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

Purpose: The aims of this study were to evaluate the expression of the large tumor suppressor () genes and by immunohistochemical staining of gastric cancer, and to evaluate the clinicopathological significance of expression and its correlation with overall survival (OS).

Materials And Methods: and expression in a tissue microarray was detected by immunohistochemistry, using 264 gastric cancer specimens surgically resected between July 2006 and December 2009.

Results: Low expression of was significantly associated with more advanced American Joint Committee on Cancer (AJCC) stage (P=0. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746657PMC
December 2017
4 Reads

Laparoscopic Reinforcement Suture (LARS) on Staple Line of Duodenal Stump Using Barbed Suture in Laparoscopic Gastrectomy for Gastric Cancer: a Prospective Single Arm Phase II Study.

J Gastric Cancer 2017 Dec 18;17(4):354-362. Epub 2017 Dec 18.

Department of Surgery, Dong-A University College of Medicine, Busan, Korea.

Purpose: Laparoscopic gastrectomy is accepted as a standard treatment for patients with early gastric cancer in Korea, Japan, and China. However, duodenal stump leakage remains a fatal complication after gastrectomy. We conducted a prospective phase II study to evaluate the safety of the new technique of laparoscopic reinforcement suture (LARS) on the duodenal stump. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5230/jgc.2017.17
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http://dx.doi.org/10.5230/jgc.2017.17.e40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746656PMC
December 2017
11 Reads

Using Quality of Life Scales with Nutritional Relevance after Gastrectomy: a Challenge for Providing Personalized Treatment.

J Gastric Cancer 2017 Dec 18;17(4):342-353. Epub 2017 Dec 18.

Center of Biostatistics, Kyungpook National University School of Medicine, Daegu, Korea.

Purpose: This study evaluated the changes in nutritional status based on quality of life (QoL) item-level analysis to determine whether individual QoL responses might facilitate personal clinical impact.

Materials And Methods: This study retrospectively evaluated QoL data obtained by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Stomach (QLQ-STO22) as well as metabolic-nutritional data obtained by bioelectrical impedance analysis and blood tests. Patients were assessed preoperatively and at the 5-year follow-up. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746655PMC
December 2017
4 Reads

Risk Factors of Microscopic Invasion in Early Gastric Cancer.

J Gastric Cancer 2017 Dec 12;17(4):331-341. Epub 2017 Dec 12.

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

Purpose: This study aimed to evaluate the clinical significance of microscopic invasion to determine the adequate resection margin in early gastric cancer (EGC).

Materials And Methods: A retrospective review was performed that included patients who underwent gastrectomy for clinical early gastric cancer (cEGC) at Seoul National University Hospital between January 2007 and December 2010. After subtracting the microscopic resection margin from the gross resection margin for each proximal or distal resection margin, microscopic invasion was represented by the larger value. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746654PMC
December 2017
7 Reads

Extensive Lymph Node Dissection Improves Survival among American Patients with Gastric Adenocarcinoma Treated Surgically: Analysis of the National Cancer Database.

J Gastric Cancer 2017 Dec 5;17(4):319-330. Epub 2017 Dec 5.

Department of Surgical Oncology, Edward Cancer Center, Naperville, IL, USA.

Introduction: The extent of lymphadenectomy in the surgical treatment of gastric cancer is a topic of controversy among surgeons. This study was conducted to analyze the American National Cancer Database (NCDB) and conclude the optimal extent of lymphadenectomy for gastric adenocarcinoma.

Methods: The NCDB for gastric cancer was utilized. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746653PMC
December 2017
51 Reads
2 Citations

Greater Lymph Node Retrieval Improves Survival in Node-Negative Resected Gastric Cancer in the United States.

J Gastric Cancer 2017 Dec 21;17(4):306-318. Epub 2017 Nov 21.

Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.

Purpose: Guidelines in western countries recommend retrieving ≥15 lymph nodes (LNs) during gastric cancer resection. This study sought to determine whether the number of examined lymph nodes (eLNs), a proxy for lymphadenectomy, effects survival in node-negative disease.

Materials And Methods: The US National Cancer Database (2003-2011) was reviewed for node-negative gastric adenocarcinoma. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746652PMC
December 2017
6 Reads

ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells.

J Gastric Cancer 2017 Dec 15;17(4):295-305. Epub 2017 Nov 15.

Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, China.

Purpose: We previously found that the histone methyltransferase suppressor of variegation, enhancer of zeste, trithorax and myeloid-nervy-deformed epidermal autoregulatory factor-1 domain-containing protein 3 (SMYD3) is a potential independent predictive factor or prognostic factor for overall survival in gastric cancer patients, but its roles seem to differ from those in other cancers. Therefore, in this study, the detailed functions of SMYD3 in cell proliferation and migration in gastric cancer were examined.

Materials And Methods: SMYD3 was overexpressed or suppressed by transfection with an expression plasmid or siRNA, and a wound healing migration assay and Transwell assay were performed to detect the migration and invasion ability of gastric cancer cells. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746651PMC
December 2017
18 Reads
2 Citations

Long-term Follow-up for Type 2 Diabetes Mellitus after Gastrectomy in Non-morbidly Obese Patients with Gastric Cancer: the Legitimacy of Onco-metabolic Surgery.

J Gastric Cancer 2017 Dec 15;17(4):283-294. Epub 2017 Nov 15.

Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Purpose: This study primarily aimed to investigate the short- and long-term remission rates of type 2 diabetes (T2D) in patients who underwent surgical treatment for gastric cancer, especially patients who were non-obese, and secondarily to determine the potential factors associated with remission.

Materials And Methods: We retrospectively reviewed the clinical records of patients with T2D who underwent radical gastrectomy for gastric cancer, from January 2008 to December 2012.

Results: T2D improved in 39 out of 70 (55. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746650PMC
December 2017
9 Reads

Erratum: Anthropometric Study of the Stomach.

J Gastric Cancer 2017 Sep 21;17(3):282. Epub 2017 Jul 21.

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

[This corrects the article on p. 247 in vol. 16, PMID: 28053811. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620098PMC
September 2017
9 Reads

Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: a Rare Case.

J Gastric Cancer 2017 Sep 25;17(3):277-281. Epub 2017 Jul 25.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a very rare mesenchymal tumor of the gastrointestinal tract. We report a case of asymptomatic gastric PAMT that was pathologically confirmed after surgical resection. The tumor had a multinodular plexiform growth pattern, bland-looking spindle cells, and an Alcian blue-positive myxoid stromal matrix rich in small blood vessels. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620097PMC
September 2017
21 Reads

Two-Layer Hand-Sewn Esophagojejunostomy in Totally Laparoscopic Total Gastrectomy for Gastric Cancer.

J Gastric Cancer 2017 Sep 16;17(3):267-276. Epub 2017 Aug 16.

Digestive Surgery Department, Hospital Clínico Pontificia Universidad Católica de Chile, Pontificia Universidad Católica de Chile, Santiago, Chile.

Purpose: Different esophagojejunostomy (EJ) reconstruction methods are used after totally laparoscopic total gastrectomy (TLTG), and none is considered a standard technique. This report describes a 2-layer hand-sewn EJ technique during TLTG; we also evaluated postoperative morbidity associated with this technique.

Materials And Methods: This retrospective cohort study included all consecutive patients who underwent TLTG for gastric cancer (GC) from 2012 to 2016 at 2 affiliated teaching hospitals. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620096PMC
September 2017
4 Reads

A Novel Roux-en-Y Reconstruction Involving the Use of Two Circular Staplers after Distal Subtotal Gastrectomy for Gastric Cancer.

J Gastric Cancer 2017 Sep 26;17(3):255-266. Epub 2017 Sep 26.

Division of Gastrointestinal Surgery, Department of Surgery, Ajou University School of Medicine, Suwon, Korea.

Purpose: Although Roux-en-Y (R-Y) reconstruction after distal gastrectomy has several advantages, such as prevention of bile reflux into the remnant stomach, it is rarely used because of the technical difficulty. This prospective randomized clinical trial aimed to show the efficacy of a novel method of R-Y reconstruction involving the use of 2 circular staplers by comparing this novel method to Billroth-I (B-I) reconstruction.

Materials And Methods: A total of 118 patients were randomly allocated into the R-Y (59 patients) and B-I reconstruction (59 patients) groups. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620095PMC
September 2017
14 Reads

Does Hospital Volume Really Affect the Surgical and Oncological Outcomes of Gastric Cancer in Korea?

J Gastric Cancer 2017 Sep 26;17(3):246-254. Epub 2017 Sep 26.

Department of Surgery, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: The significance of hospital volume remains inconsistent and controversial. In particular, few studies have examined whether hospital volume is associated with the outcome of gastrectomy for gastric cancer in East Asia. This study examined the effect of hospital volume on the short-term surgical and long-term oncological outcomes of patients undergoing curative gastrectomy for gastric cancer. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620094PMC
September 2017
27 Reads

Laparoscopic Gastrectomy Performed by an Expert in Open Gastrectomy.

J Gastric Cancer 2017 Sep 20;17(3):237-245. Epub 2017 Sep 20.

Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea.

Purpose: Senior surgeons prefer open gastrectomy (OG), while young surgeons prefer laparoscopic gastrectomy (LG). The purpose of this study was to evaluate the surgical outcomes of LG performed by a senior surgeon who was an expert in OG during his learning period, by comparing them with LGs performed by a young surgeon.

Materials And Methods: A senior surgeon performed 50 curative gastrectomies with laparoscopy (LG-S group) from March 2015 to August 2016. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620093PMC
September 2017
4 Reads

Overexpression of Neuron-Specific Enolase as a Prognostic Factor in Patients with Gastric Cancer.

J Gastric Cancer 2017 Sep 25;17(3):228-236. Epub 2017 Aug 25.

Gyeongnam Regional Cancer Center, Gyeongsang National University School of Medicine, Jinju, Korea.

Purpose: Enolase is a cytoplasmic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. The aim of this study was to investigate whether the overexpression of neuron-specific enolase (NSE) can serve as a prognostic factor in patients with gastric cancer (GC).

Materials And Methods: To assess its prognostic value in GC, NSE expression was measured by immunohistochemistry in a clinically annotated tissue microarray comprising of 327 human GC specimens. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620092PMC
September 2017
11 Reads

A Promising Method for Tumor Localization during Total Laparoscopic Distal Gastrectomy: Preoperative Endoscopic Clipping based on Negative Biopsy and Selective Intraoperative Radiography Findings.

J Gastric Cancer 2017 Sep 25;17(3):220-227. Epub 2017 Aug 25.

Department of Surgery, Kosin University College of Medicine, Busan, Korea.

Purpose: Precise localization of tumors and creation of sufficient proximal resection margins are complicated processes during total laparoscopic distal gastrectomy (TLDG) for clinical T1/T2 gastric cancers. Various solutions to this problem have also yielded many disadvantages. In this study, we reviewed a preoperative endoscopic clipping method based on the results of negative biopsy and selective intraoperative radiography. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620091PMC
September 2017
11 Reads

Comparison of the Differences in Survival Rates between the 7th and 8th Editions of the AJCC TNM Staging System for Gastric Adenocarcinoma: a Single-Institution Study of 5,507 Patients in Korea.

J Gastric Cancer 2017 Sep 31;17(3):212-219. Epub 2017 Jul 31.

Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea School of Medicine, Seoul, Korea.

Purpose: The aims of this study were to compare the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging manuals on tumor, node, and metastasis (TNM) staging systems and to evaluate whether the 8th edition represents a better refinement of the 7th staging system, when applied for the classification of gastric cancers.

Materials And Methods: A total of 5,507 gastric cancer patients, who underwent treatment from January 1989 to December 2013 at a single institute, were included. We compared patient survival rates across the disease groups classified according to the 7th and 8th editions of the AJCC TNM staging systems. Read More

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http://dx.doi.org/10.5230/jgc.2017.17.e23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620090PMC
September 2017
8 Reads