2,530 results match your criteria Journal of diabetes and its complications[Journal]


Liraglutide prevents β-cell apoptosis via inactivation of NOX2 and its related signaling pathway.

J Diabetes Complications 2019 Jan 2. Epub 2019 Jan 2.

NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin 300070, PR China. Electronic address:

Aims: High glucose (HG)-induced pancreatic β-cell apoptosis may be a major contributor to the progression of diabetes mellitus (DM). NADPH oxidase (NOX2) has been considered a crucial regulator in β-cell apoptosis. This study was designed to evaluate the impact of GLP-1 receptor agonist (GLP-1Ra) liraglutide on pancreatic β-cell apoptosis in diabetes and the underlying mechanisms involved. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.013DOI Listing
January 2019
1 Read

Obesity, visceral adiposity and carotid atherosclerosis.

J Diabetes Complications 2019 Jan 17. Epub 2019 Jan 17.

Department of Cardiology, School of Health Sciences, Medical University of Silesia, Katowice, Poland.

Carotid artery atherosclerosis is a complex and multifactorial chronic disease. Our aim was to assess the associations between obesity, fat depots and carotid artery stenosis (CAS) in patients with high cardiovascular (CV) risk.

Methods: The study group included 391 patients (F/M: 136/255 pts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.002DOI Listing
January 2019
1 Read

Role of sex in post-transplant diabetes mellitus development: Are men and women equal?

J Diabetes Complications 2019 Jan 4. Epub 2019 Jan 4.

Ist Department of Internal Diseases, University Hospital Martin and Jessenius Medical Faculty of Comenius University, Slovak Republic.

Introduction: Sex differences are defined as biology-linked differences between women and men that occur through the sex chromosomes and their effects on organ systems.

Material And Methods: The objective of this prospective study was to determine risk factors for post-transplant diabetes mellitus (PTDM) in men and women.

Results: A total of 417 patients (271 men and 146 women) were included in the monitored group. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.017DOI Listing
January 2019
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Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes.

J Diabetes Complications 2019 Jan 4. Epub 2019 Jan 4.

Department of Clinical Medicine, Aalborg University, Søndre Skovvej 11, 9000 Aalborg, Denmark; Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

Aims: Emerging evidence shows, that distal symmetric peripheral neuropathy (DSPN) also involves alterations in the central nervous system. Hence, the aims were to investigate brain metabolites in white matter of adults with diabetes and DSPN, and to compare any cerebral disparities with peripheral nerve characteristics.

Methods: In type 1 diabetes, brain metabolites of 47 adults with confirmed DSPN were compared with 28 matched healthy controls using proton magnetic resonance spectroscopy (H-MRS) in the parietal region including the sensorimotor fiber tracts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.016DOI Listing
January 2019
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Understanding the importance of Food Insecurity among populations with diabetes.

Authors:
Candice A Myers

J Diabetes Complications 2018 Dec 22. Epub 2018 Dec 22.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.008DOI Listing
December 2018

The longitudinal relationship between food insecurity in older adults with diabetes and emergency department visits, hospitalizations, hemoglobin A1c, and medication adherence.

J Diabetes Complications 2018 Dec 6. Epub 2018 Dec 6.

Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO, United States; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Aims: To examine the relationship between food insecurity and emergency department (ED) visits, hospitalizations, A1c, and diabetes medication adherence over one year of follow-up among individuals >65 years with diabetes mellitus.

Methods: We conducted a longitudinal cohort study of adults >65 years with diabetes who did (n = 742) or did not (n = 2226) report food insecurity at baseline. We used conditional logistic regression for the ED visits or hospitalization outcomes, and mixed effects models for A1c and non-insulin diabetes medication adherence. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.011DOI Listing
December 2018

Impact of diabetes and hyperglycemia on health care utilization, infection risk, and survival in patients with cancer receiving glucocorticoids with chemotherapy.

J Diabetes Complications 2019 Jan 3. Epub 2019 Jan 3.

International Diabetes Center, Park Nicollet, Minneapolis, MN, USA.

Background: Glucocorticoids are commonly used in chemotherapy regimens and may lead to hyperglycemia and increased infection rates.

Methods: We performed a retrospective analysis on 1781 patients who received intravenous chemotherapy with glucocorticoids between 2010 and 2015. Data was obtained using electronic medical record, billing modules, and tumor registry. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.012DOI Listing
January 2019

Identifying solutions to psychological insulin resistance: An international study.

J Diabetes Complications 2019 Jan 17. Epub 2019 Jan 17.

Eli Lilly and Company, Indianapolis, IN, USA.

Aims: To identify actions of healthcare professionals (HCPs) that facilitate the transition to insulin therapy (IT) in type 2 diabetes (T2D) adults.

Methods: Included were T2Ds in seven countries (n = 594) who reported initial IT reluctance but eventually began IT. An online survey included 38 possible HCP actions: T2Ds indicated which may have occurred and their helpfulness. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.001DOI Listing
January 2019

Stress hyperglycemia: A prospective study examining the relationship between glucose, cortisol and diabetes in myocardial infarction.

J Diabetes Complications 2019 Jan 4. Epub 2019 Jan 4.

Dept of Diabetes & Endocrinology, Blacktown Hospital, Blacktown 2148, Australia; Western Sydney University, Penrith, NSW 2751, Australia. Electronic address:

Aim: We aimed to explore the relationship between stress, hyperglycemia and diabetes in myocardial infarction (MI), using serum cortisol as a surrogate marker for the severity of stress.

Methods: Subjects with acute MI were prospectively recruited upon hospital admission. Serum glucose and cortisol were measured in addition to standard testing. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.015DOI Listing
January 2019
1 Read

Lower cardiovagal tone and baroreflex sensitivity associated with hepatic insulin resistance and promote cardiovascular disorders in Tibetan minipigs induced by a high fat and high cholesterol diet.

J Diabetes Complications 2019 Jan 4. Epub 2019 Jan 4.

Comparative Medical Research Institute, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address:

Aims: A long-term high-fat/cholesterol (HFC) diet leads to hepatic insulin resistance (IR), which is associated with autonomic dysfunction and cardiovascular diseases risk increasing. However, whether this occurs in Tibetan minipigs remains unknown. We tested that a long-term HFC diet caused hepatic IR and promote cardiovascular disorders in Tibetan minipigs, and are associated with the reduction of cardiovagal tone and baroreflex sensitivity (BRS). Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.014DOI Listing
January 2019
1 Read

Challenging the conventional wisdom on diabetic nephropathy: Is microalbuminuria the earliest event?

J Diabetes Complications 2019 Mar 14;33(3):191-192. Epub 2018 Dec 14.

Tulane University Health Sciences Center, New Orleans, LA 70112, United States of America; Southeast Louisiana Veterans Health Care System, New Orleans, LA 70112, United States of America.

Microalbuminuria, urine albumin-to-creatinine ratio >30 and less than <300 mg/g has widely been accepted as biomarker of early diabetic kidney disease (DKD). Based on absence of beta-2 microglobulinuria in earlier studies on microalbuminuria, its possible tubular origin has been dismissed. Microalbuminuria has been assumed as a marker of endothelial injury. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.006DOI Listing
March 2019
2 Reads

Altered responses to pneumococcal vaccination in an elderly diabetic Japanese vaccine trial: The risk of concurrent vaccination strategies.

J Diabetes Complications 2019 Mar 21;33(3):189-190. Epub 2018 Dec 21.

Department of Microbiology & Immunology, Tulane University School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.007DOI Listing

Nutrigenetic effects in metabolic syndrome - A cornerstone for individualized therapy.

Authors:
Stefan Kabisch

J Diabetes Complications 2019 Mar 28;33(3):193-194. Epub 2018 Nov 28.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany; German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung e.V.; DZD), Geschäftsstelle am Helmholtz-Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.008DOI Listing
March 2019
1 Read

The effect of structured personal care on RNA oxidation: A 19-year follow-up of the randomized trial Diabetes Care in General Practice (DCGP).

J Diabetes Complications 2019 Mar 11;33(3):202-207. Epub 2018 Dec 11.

Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims: The urinary marker of RNA oxidation, 8‑oxo‑7,8‑dihydroguanosine (8-oxoGuo), but not the corresponding marker of DNA oxidation, 8‑oxo‑7,8‑dihydro‑2'‑deoxyguanosine (8-oxodG), is a prognostic biomarker in patients with type 2 diabetes (T2D). The aim of the present study was to investigate the effect of structured personal care (individualized multifactorial treatment) versus standard care on RNA oxidation level in patients with T2D and to assess if the effect of structured personal care on all-cause and diabetes-related mortality was modified by RNA oxidation level.

Methods: Urine samples were analyzed for 8-oxoGuo/8-oxodG from 1381 newly diagnosed T2D patients from the cluster randomized trial Diabetes Care in General Practice cohort, and 970 patients were reexamined after six years of intervention. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.004DOI Listing

Analysis of sphingolipid composition in human vitreous from control and diabetic individuals.

J Diabetes Complications 2019 Mar 14;33(3):195-201. Epub 2018 Dec 14.

The University of Tennessee Health Science Center, Department of Ophthalmology, Memphis, TN 38163, USA; The University of Tennessee Health Science Center, Department of Anatomy and Neurobiology, Memphis, TN 38163, USA; The University of Oklahoma Health Science Center, Department of Ophthalmology, Oklahoma City, OK 73104, USA. Electronic address:

Objective: Sphingolipids have a fundamental role in many cellular processes, and they have been implicated in insulin resistance and Diabetes Mellitus (DM) and its complications, including diabetic retinopathy (DR). Little is known about how bioactive sphingolipids relate to retinopathies in human DM. In this study, we analyzed the sphingolipid composition of type 2 diabetic (T2DM) and non-diabetic human vitreous samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183067
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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368445PMC
March 2019
4 Reads

Patient-reported barriers and outcomes associated with poor glycaemic and blood pressure control in co-morbid diabetes and chronic kidney disease.

J Diabetes Complications 2019 Jan 12;33(1):63-68. Epub 2018 Oct 12.

School of Public Health and Preventive Medicine, Monash University, VIC, Australia; Diabetes and Vascular Medicine Unit, Monash Health, VIC, Australia; The George Institute for Global Health, NSW, Australia. Electronic address:

Aims: In patients with comorbid diabetes and chronic kidney disease, the extent to which patient-reported barriers to health-care and patient reported outcomes influence the quality of health care is not well established. This study explored the association between patient-reported barriers to health-care, patient activation, quality of life and diabetes self-care, with attainment of glycaemic and blood pressure (BP) targets.

Methods: This cross-sectional study recruited adults with diabetes and CKD (eGFR 20 to <60 ml/min/1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183039
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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.020DOI Listing
January 2019
5 Reads
1.925 Impact Factor

Exploratory metabolomics of nascent metabolic syndrome.

J Diabetes Complications 2019 Mar 10;33(3):212-216. Epub 2018 Dec 10.

California North-state University College of Medicine, United States of America. Electronic address:

Introduction: Metabolic syndrome (MetS) is a disorder defined by having three of five features: increased waist circumference (WC), hypertriglyceridemia, decreased high-density lipoprotein-cholesterol, hypertension and an elevated blood glucose (BG). Metabolic Syndrome ( MetS) affects 35% of American adults and significantly increases risk for Atherosclerotic cardiovascular disease (ASCVD) and type-2 diabetes (T2DM). An understanding of the metabolome will help elucidate the pathogenesis of MetS and lead to better management. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.002DOI Listing
March 2019
1 Read

Efficacy and tolerability of exenatide once weekly over 7 years in patients with type 2 diabetes: An open-label extension of the DURATION-1 study.

J Diabetes Complications 2019 Mar 5;33(3):223-230. Epub 2018 Dec 5.

AstraZeneca, Gaithersburg, MD, USA.

Aims: To investigate the glycemic efficacy, effects on cardiovascular risk factors, and safety of exenatide once weekly (QW) in patients with type 2 diabetes over 7 years in the DURATION-1 study.

Methods: Patients were initially randomized to exenatide QW 2 mg or exenatide twice daily for 30 weeks, after which they received open-label, open-ended treatment with exenatide QW 2 mg for up to 7 years. Efficacy analyses included changes from baseline in glycated hemoglobin (HbA) and cardiovascular risk factors. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.012DOI Listing

Efficacy and safety of insulin glargine/lixisenatide (iGlarLixi) fixed-ratio combination in older adults with type 2 diabetes.

J Diabetes Complications 2019 Mar 30;33(3):236-242. Epub 2018 Nov 30.

National Research Institute, 2010 Wilshire Blvd #302, Los Angeles, 90057, CA, USA. Electronic address:

Aims: This study assessed the efficacy and safety of iGlarLixi (a titratable, fixed-ratio combination of insulin glargine [iGlar] plus lixisenatide) in older patients with type 2 diabetes.

Methods: This post hoc analysis used patient-level data from patients aged ≥65 years from the phase III LixiLan-O and LixiLan-L studies, which compared iGlarLixi with iGlar and lixisenatide (LixiLan-O only). Efficacy endpoints were changes in glycated hemoglobin A1C, fasting plasma glucose, postprandial glucose, weight, and achievement of A1C <7. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.009DOI Listing
March 2019
4 Reads

Depressive symptom dimensions and medication non-adherence in suboptimally controlled type 2 diabetes.

J Diabetes Complications 2019 Mar 7;33(3):217-222. Epub 2018 Dec 7.

Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA; Department of Medicine (Endocrinology), Albert Einstein College of Medicine, Bronx, NY, USA; The Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, NY, USA.

Aims: Research suggests differential effects for somatic and cognitive-affective depressive symptoms in predicting health outcomes. This study evaluated differential relations with medication non-adherence among disadvantaged, and predominantly immigrant adults with sub-optimally controlled type 2 diabetes (T2D).

Methods: Health plan members taking oral diabetes medication and who had A1c ≥ 7. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183078
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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.001DOI Listing
March 2019
2 Reads

Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis.

J Diabetes Complications 2019 Mar 8;33(3):208-211. Epub 2018 Dec 8.

Department of Internal Medicine, Brothers of Mercy Hospital, Brno, Czech Republic; 2nd Department of Surgery, Faculty of Medicine, St. Anne's University Hospital, Brno, Czech Republic. Electronic address:

Purpose: The aim of this work was to study the association of serum ionized calcium with retinal photoreceptor apoptosis on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR).

Methods: Sixty consecutive cases with Type 2 diabetes mellitus were categorized into three groups: no diabetic retinopathy; non-proliferative DR; proliferative DR. The eye with more severe form of the disease was considered. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183109
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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.003DOI Listing
March 2019
1 Read

1,5 Anhydroglucitol in gestational diabetes mellitus.

J Diabetes Complications 2019 Mar 5;33(3):231-235. Epub 2018 Dec 5.

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, ICMR Centre for Advanced Research on Diabetes, Gopalapuram, Chennai, India. Electronic address:

Objective: 1,5 Anhydroglucitol (1,5 AG) is reported to be a more sensitive marker of glucose variability and short-term glycemic control (1-2 weeks) in patients with type1 and type 2 diabetes. However, the role of 1,5 AG in gestational diabetes mellitus (GDM) is not clear. We estimated the serum levels of 1,5 AG in pregnant women with and without GDM. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.010DOI Listing
March 2019
1 Read

Altered immunogenicity of 23-valent pneumococcal polysaccharide vaccine in elderly patients with diabetes who revealed lower responses to concomitant administration of BIKEN varicella zoster vaccine: Results of post hoc analysis of a randomized double-blind trial.

J Diabetes Complications 2019 Mar 22;33(3):243-248. Epub 2018 Nov 22.

Department of Hygiene and Public Health, Teikyo University School of Medicine, 2-11-1 Kaga Itabashi-ku, Tokyo 173-8605, Japan.

Aims: This double-blind randomized controlled study of 52 elderly patients with diabetes assessed cell-mediated immunity and safety of BIKEN varicella-zoster vaccine (BVZV). Cellular and humoral responses to VZV at 3 months after BVZV and 23-valent polysaccharide pneumococcal vaccine (PPSV23) vaccination elicited poor results. Post-hoc analyses assessed the effects of immunogenicity of PPSV23. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.003DOI Listing

Potential role of E4orf1 protein in aging-associated impairment in glycemic control.

J Diabetes Complications 2019 Mar 22;33(3):261-265. Epub 2018 Nov 22.

Obesity and Metabolic Health Laboratory, Nutritional Sciences Department, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

Aging constitutes a major risk factor for the development of type-2 diabetes (T2D) where glucose tolerance declines with age, resulting in a high prevalence of T2D and impaired glucose tolerance in the elderly population. Currently more than half of the 20 million U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183102
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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.006DOI Listing
March 2019
5 Reads

An investigation into the durability of glycemic control in patients with type II diabetes initiated on canagliflozin or sitagliptin: A real-world analysis of electronic medical records.

J Diabetes Complications 2019 Feb 31;33(2):140-147. Epub 2018 Oct 31.

Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA. Electronic address:

Aims: The aims of this study were to assess glycemic control, weight loss, and durability of glycemic control in patients initiated on canagliflozin (CANA) versus sitagliptin (SITA).

Methods: Adults with type II diabetes mellitus initiated on CANA or SITA (index date) were identified from IQVIA™ Real-World Data Electronic Medical Records - US database (03/29/2012-04/30/2016). Inverse probability of treatment weighting accounted for baseline differences between cohorts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.016DOI Listing
February 2019

Epidermal growth factor receptor and podocin predict nephropathy progression in type 2 diabetic patients through interaction with the autophagy influencer ULK-1.

J Diabetes Complications 2019 Feb 22;33(2):128-133. Epub 2018 Nov 22.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Aims: Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.007DOI Listing
February 2019
10 Reads

Sex differences in the association of psychosocial resources with prevalent type 2 diabetes among African Americans: The Jackson Heart Study.

J Diabetes Complications 2019 Feb 22;33(2):113-117. Epub 2018 Nov 22.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Aim: To examine the association of psychosocial resources with prevalent type 2 diabetes (T2D) in 5104 African American men and women.

Methods: Using data from the Jackson Heart Study (JHS), we evaluated the cross-sectional associations of four psychosocial resources (social support, optimism, religiosity, and social networks) with T2D [fasting glucose ≥126 mg/dL, or HbA1c ≥ 6.5%, or use of diabetic medication]. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.005DOI Listing
February 2019

Gestational diabetes mellitus alters DNA methylation profiles in pancreas of the offspring mice.

J Diabetes Complications 2019 Jan 9;33(1):15-22. Epub 2018 Nov 9.

Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China; Department of Scientific Research, Fujian Academy of Medical Sciences, Fuzhou, Fujian, China. Electronic address:

Gestational diabetes mellitus (GDM), which has an increasing global prevalence, contributes to the susceptibility to metabolic dysregulation and obesity in the offspring via epigenetic modifications. However, the underlying mechanism remains largely obscure. The current study established a GDM mice model to investigate the alternations in the metabolic phenotypes and genomic DNA methylation in the pancreas of the offspring. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.002DOI Listing
January 2019
1.925 Impact Factor

Dendritic cell activation is blunted in patients with coronary artery disease and diabetes mellitus.

J Diabetes Complications 2019 Feb 23;33(2):134-139. Epub 2018 Nov 23.

Yenisehir Hospital Division of Cardiology, Mersin, Turkey. Electronic address:

Background: It has been shown that functional status of dendritic cells (DCs) in diabetic patients with unstable angina pectoris (UAP) are more mature and activated than diabetic patients without coronary artery disease (CAD) and none diabetic patients with UAP. Accordingly we aimed to assess the activation of DCs in patients with CAD with/and without Diabetes Mellitus (DM) and compare to those in subjects with normal coronary arteries (NCA).

Materials And Methods: Twenty three patients with severe CAD who were scheduled to coronary artery by-pass grafting surgery and 6 patients with angiographycally NCAs were included in the study. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.004DOI Listing
February 2019
1 Read

Long-term effects of insulin resistance on appendicular lean muscle.

J Diabetes Complications 2019 Jan 9;33(1):13-14. Epub 2018 Nov 9.

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA; Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.019DOI Listing
January 2019

The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, β-cell function, and diabetes in Hispanics and African Americans.

J Diabetes Complications 2019 Feb 3;33(2):118-122. Epub 2018 Nov 3.

Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America; VA Eastern Colorado Health Care System, Denver, CO 80220, United States of America. Electronic address:

Objective: The TG/HDL-C ratio is used as a marker of insulin resistance (IR) in Caucasians; however, there is limited data in other ethnic groups. We hypothesized that the TG/HDL-C ratio is associated with IR in Hispanics and African Americans (AA).

Research Design And Methods: Data from the Insulin Resistance Atherosclerosis Family Study was examined for associations between TG/HDL-C ratio and IR, β-cell function and incident diabetes in non-diabetic Hispanics (n = 872, 63% female) and AA (n = 371, 61% female). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183089
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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331279PMC
February 2019
7 Reads

PAX4 R192H is associated with younger onset of Type 2 diabetes in East Asians in Singapore.

J Diabetes Complications 2019 Jan 13;33(1):53-58. Epub 2018 Oct 13.

Clinical Research Unit, Khoo Teck Puat Hospital (KTPH), Singapore; Diabetes Center, Khoo Teck Puat Hospital (KTPH), Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

Aims: Young-onset T2D (YT2D) is associated with a more fulminant course and greater propensity for diabetic complications. The association of PAX4 R192H (rs2233580) variation with YT2D was inconsistent partly because of its Asian-specificity and under-representation of Asians in international consortiums. Interestingly, in our preliminary YT2D (mean = 25 years old) cohort, the prevalence of PAX4 R192H variant was remarkably higher (21. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183022
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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.002DOI Listing
January 2019
2 Reads
1.925 Impact Factor

Targeting inflammation to reduce ASCVD in type 2 diabetes.

J Diabetes Complications 2019 Jan 8;33(1):1-3. Epub 2018 Nov 8.

University at Buffalo, Buffalo, NY, United States of America.

ASCVD is the leading cause of mortality in T2DM. Inflammation appears to be pivotal in the genesis of ASCVD. As T2DM is also a pro-inflammatory state, our aim was to determine the benefit of anti-inflammatory strategies on ASCVD in T2DM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183108
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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.001DOI Listing
January 2019
6 Reads

Clinical features and long-term outcomes of diabetic kidney disease - A prospective cohort study from China.

J Diabetes Complications 2019 Jan 12;33(1):39-45. Epub 2018 Oct 12.

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China; Peking University, Center for Data Science in Health and Medicine, Beijing, China. Electronic address:

Background: Information regarding the clinical phenotypes of diabetic kidney disease (DKD) might guide better practice for clinicians. We aim to compare the clinical features and long-term outcomes of proteinuric and non-proteinuric phenotypes of DKD, based on a prospective cohort of Chinese population.

Methods: Altogether 8811 Chinese participants with diabetes were included. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.019DOI Listing
January 2019

Low proliferative potential of adipose-derived stromal cells associates with hypertrophy and inflammation in subcutaneous and omental adipose tissue of patients with type 2 diabetes mellitus.

J Diabetes Complications 2019 Feb 4;33(2):148-159. Epub 2018 Nov 4.

Endocrinology Research Centre, Moscow, Russia.

Background: Obesity and type 2 diabetes mellitus (T2DM) are among the most important morbidity factors. In this study we tested the hypothesis that low proliferative potential of adipose derived stromal cells (ADSC) associates with reduced formation of new fat depots, excess accumulation of fat in the functional adipocytes and their hypertrophy, resulting in fat inflammation and insulin resistance.

Methods: We screened two groups of obese patients with or without T2DM, matched for BMI, age, and duration of obesity to test the hypothesis that hypertrophy and decreased renewal of adipocytes may underlie transition from obesity to T2DM. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.011DOI Listing
February 2019
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Self-reported physical activity in community-dwelling adults with diabetes and its association with diabetes complications.

J Diabetes Complications 2019 Jan 4;33(1):33-38. Epub 2018 Nov 4.

School of Health Sciences, University of Newcastle, NSW, Australia; Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, NSW, Australia.

Aims: To describe the physical activity levels of an Australian community-based adult population with diabetes, and investigate the interaction between diabetes complications and physical activity.

Methods: Anthropometric, demographic, biochemical and self-reported physical activity measures (IPAQ) were performed. Associations and multiple regression analyses were undertaken between physical activity, known risk factors for diabetes complications, and history of cardiovascular disease (CVD), neuropathy and foot ulceration obtained from medical records. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.017DOI Listing
January 2019

Role of rs670 variant of APOA1 gene on metabolic response after a high fat vs. a low fat hypocaloric diets in obese human subjects.

J Diabetes Complications 2019 Mar 3;33(3):249-254. Epub 2018 Nov 3.

Endocrinology and Nutrition Research Center, School of Medicine, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.

Background & Aims: A common G-to-A transition located 75 base pairs upstream (rs670) from transcription start site of the APOA1 gene has been related with some metabolic parameters. Our aim was to analyze the effects of rs670 APOA1 gene polymorphism on lipid profile and metabolic changes after two different hypocaloric diets.

Methods: 282 obese subjects were randomly allocated during 12 weeks (Diet HF - high fat diet vs. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.015DOI Listing
March 2019
2 Reads

The association of diabetic microvascular and macrovascular disease with cutaneous circulation in patients with type 2 diabetes mellitus.

J Diabetes Complications 2019 Feb 12;33(2):165-170. Epub 2018 Oct 12.

Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. Electronic address:

Aims: To study the impact of diabetic neuropathy, both peripheral sensorimotor (DPN) and cardiac autonomic neuropathy (CAN), on transcutaneous oxygen tension (TcPO) in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 163 participants were recruited; 100 with T2DM and 63 healthy individuals. Peripheral arterial disease (PAD) was defined as ankle-brachial index (ABI) values ≤0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183039
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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.008DOI Listing
February 2019
8 Reads

Prognostic tools for cardiovascular disease in patients with type 2 diabetes: A systematic review and meta-analysis of C-statistics.

J Diabetes Complications 2019 Jan 23;33(1):98-111. Epub 2018 Oct 23.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada; Department of Family Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada. Electronic address:

Background: Diabetes is associated with an increased risk for cardiovascular diseases (CVD). Risk prediction models are tools widely used to identify individuals at particularly high-risk of adverse events. Many CVD risk prediction models have been developed but their accuracy and consistency vary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183096
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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.010DOI Listing
January 2019
5 Reads

Freestyle Libre trend arrows for the management of adults with insulin-treated diabetes: A practical approach.

J Diabetes Complications 2019 Jan 24;33(1):6-12. Epub 2018 Oct 24.

Department of Clinical and Experimental Medicine, Section of Diabetes and Metabolic Diseases, University of Pisa - Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.

Freestyle Libre (FSL) system is a new method to detect glucose enabling a new paradigm in glucose monitoring and self-management. The sensor, reading the interstitial fluid glucose concentration, provides a numerical data of glucose level and a trend arrow that add context to static measurement of glucose level. Therefore, patients could easily follow the progression of their glucose levels over the time, allowing early detection and timely treatment of deviations from targeted glucose level range, thus preventing extreme fluctuations. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.012DOI Listing
January 2019
52 Reads

An altered spatiotemporal gait adjustment during a virtual obstacle crossing task in patients with diabetic peripheral neuropathy.

J Diabetes Complications 2019 Feb 17;33(2):182-188. Epub 2018 Oct 17.

Division of Physical Therapy Education, College of Allied Health Professions, University of Nebraska Medical Center (UNMC), Omaha, NE, United States of America; Department of Biomechanics, College of Education, University of Nebraska at Omaha (UNO), NE, United States of America. Electronic address:

This study investigates spatiotemporal gait adjustments that occur while stepping over virtual obstacles during treadmill walking in people with/without diabetic peripheral neuropathy (DPN). Eleven adults with Type 2 diabetes mellitus, ten DPN, and 11 age-matched healthy adults (HTY) participated in this study. They stepped over forthcoming virtual obstacles during treadmill walking. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331236PMC
February 2019
10 Reads

Endothelial cell-specific overexpression of endothelial nitric oxide synthase in Ins2Akita mice exacerbates diabetic nephropathy.

J Diabetes Complications 2019 Jan 13;33(1):23-32. Epub 2018 Oct 13.

Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address:

Previous studies demonstrated that global deficiency of eNOS in diabetic mice exacerbated renal lesions and that overexpression of eNOS may protect against tissue injury. Our study revealed for the first time overexpression of eNOS leads to disease progression rather than protection. Transgenic mice selectively expressing eNOS in endothelial cells (eNOSTg) were cross bred with Ins2Akita type-1 (AK) diabetic mice to generate eNOS overexpressing eNOSTg/AK mice. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344355PMC
January 2019
13 Reads

Association of hyperglycemia episodes on long-term mortality in type 2 diabetes mellitus with vascular dementia: A population-based cohort study.

J Diabetes Complications 2019 Feb 25;33(2):123-127. Epub 2018 Oct 25.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Aim: This study investigated the effect of severe hyperglycemia episodes on survival and associated factors related to risk of mortality in type 2 diabetes mellitus (DM) patients with dementia.

Methods: We enrolled all type 2 DM patients newly diagnosed as having dementia in Taiwan from 1998 to 2005. These patients were categorized into those who had hyperglycemia episodes and those who did not based on whether or not they had been hospitalized for hyperglycemia after dementia diagnosis. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.014DOI Listing
February 2019
6 Reads

Contribution of HLA-DQ2/DQ8 haplotypes in type one diabetes patients with/without celiac disease.

J Diabetes Complications 2019 Jan 25;33(1):59-62. Epub 2018 Oct 25.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Based on lack of data on the distribution of the related alleles in the T1D population in Iranian population, we assessed the frequency of HLA DQ2 and DQ8 haplotypes in patients with T1D with/without CD compared to healthy population.

Materials And Methods: 70 patients with T1D without celiac disease, 60 T1D cases with CD were compared to 150 healthy individuals during 2016. Ten mililiter Gheparinized blood samples were collected, genomic DNA was extracted and alleles were genotyped by Real-time PCR using SYBR Green as a low-resolution method. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.001DOI Listing
January 2019
2 Reads
1.925 Impact Factor

Diabetes mellitus and the risk of abdominal aortic aneurysm: A systematic review and meta-analysis of prospective studies.

J Diabetes Complications 2018 Dec 15;32(12):1169-1174. Epub 2018 Sep 15.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.

Background: Diabetes mellitus has been associated with reduced risk of abdominal aortic aneurysm in a number of epidemiological studies, however, until recently little data from prospective studies have been available. We therefore conducted a systematic review and meta-analysis of prospective studies to quantify the association.

Material And Methods: Two investigators searched the PubMed and Embase databases for studies of diabetes and abdominal aortic aneurysm up to May 8th 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183076
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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.009DOI Listing
December 2018
24 Reads

Contact lens wear and the diabetic corneal epithelium: A happy or disastrous marriage?

J Diabetes Complications 2019 Jan 27;33(1):75-83. Epub 2018 Sep 27.

The Department of Ophthalmology, The University of Texas Southwestern Medical Center, United States of America. Electronic address:

Diabetes mellitus is an epidemic in the US and abroad. With the advent of new contact lens technology, the use of contact lenses as glucose sensors in lieu of the traditional finger stick is quickly becoming realized. This has the potential to rapidly expand the contact lens market into this growing patient population. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.015DOI Listing
January 2019
9 Reads

The effect of radial pulse spectrum on the risk of major adverse cardiovascular events in patients with type 2 diabetes.

J Diabetes Complications 2019 Feb 18;33(2):160-164. Epub 2018 Oct 18.

JinMu Health Technology, Taipei, Taiwan, ROC.

Radial pulse spectrum has been shown to correlate with coronary stenosis in patients with type 2 diabetes mellitus (T2DM). In academia, it has not been demonstrated that the radial artery pulse spectrum is an independent risk factor for major adverse cardiovascular events (MACE), including myocardial infarction, stroke, and all-cause mortality. The primary objective of this study is to assess the risk of MACE, in patients with T2DM and to determine if an increase in MACE would be associated with a first harmonic (C1) increase in the radial artery pulse. Read More

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February 2019
2 Reads

Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies.

J Diabetes Complications 2019 Jan 13;33(1):46-52. Epub 2018 Oct 13.

Charles University, Third Faculty of Medicine, Prague, Czech Republic.

Background: Testing for autoantibodies against the zinc transporter ZnT8 (ZnTA) is becoming routine in pediatric diabetes. However, available data are inconclusive when focusing on adult-onset diabetes, including autoimmune diabetes, which does not require insulin at diagnosis (LADA).

Basic Procedures: We examined the ZnTA prevalence and titers and matched them with the clinical phenotype and PTPN22 genotypes of Czech LADA patients who were positive for GADA and/or IA2A and had a fasting C-peptide level >200 pmol/L at diagnosis as well as HNF4A-, GCK- or HNF1A-MODY patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.004DOI Listing
January 2019

Association of the genetic variant rs2000999 with haptoglobin and diabetic macrovascular diseases in Chinese patients with type 2 diabetes.

J Diabetes Complications 2019 Feb 11;33(2):178-181. Epub 2018 Oct 11.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, People's Republic of China. Electronic address:

Aims: The common copy number variant (CNV) in the haptoglobin (Hp) gene may influence the susceptibility to diabetic macrovascular diseases. We aimed to investigate the relationship of the genetic variant rs2000999, located in the haptoglobin-related protein (HPR) gene, with serum Hp levels and diabetic macrovascular diseases in Chinese type 2 diabetes patients.

Methods: The Hp CNV and rs2000999 were genotyped in a group of 5457 Chinese patients with type 2 diabetes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727173156
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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.006DOI Listing
February 2019
7 Reads

Cognition in elderly with type 1 diabetes: Is there an interaction between glycemia and aging?

J Diabetes Complications 2019 Jan 12;33(1):4-5. Epub 2018 Oct 12.

Department of Medical Psychology, Amsterdam University Medical Centers, Free University, Amsterdam, the Netherlands; Department of Medical Psychology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jdiacomp.2018.04.013DOI Listing
January 2019