2,552 results match your criteria Journal of diabetes and its complications[Journal]


Can a combination of lifestyle and clinical characteristics explain the presence of foot ulcer in patients with diabetes?

J Diabetes Complications 2019 Mar 1. Epub 2019 Mar 1.

Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Abbas Medical Centre, Dar es Salaam, Tanzania.

Aims: The aim of this study was to identify the biomechanical, neurological and clinical parameters along with other demographics and lifestyle risk factors that could explain the presence of foot ulcer in patients with diabetes in Africa.

Methods: A total of 1270 (M/F:696/574) patients; 77(M/F:53/24) with ulcerated vs 1193 (M/F: 643/550) with non-ulcerated feet; participated in this study. A set of 28 parameters were collected and compared between the participants with and without active foot ulcers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183067
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http://dx.doi.org/10.1016/j.jdiacomp.2019.02.006DOI Listing
March 2019
1 Read

The LEADER trial in type 2 diabetes: Were the characteristics and outcomes of the participants representative?

J Diabetes Complications 2019 Mar 25. Epub 2019 Mar 25.

Medical School, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.

Aims: To compare the characteristics and outcomes of people with type 2 diabetes recruited to the LEADER trial to those of participants in the contemporaneous community-based Fremantle Diabetes Study Phase II (FDS2) who fulfilled LEADER entry criteria.

Methods: Baseline characteristics of LEADER and LEADER-eligible FDS2 participants were compared using bivariate methods. Incidence rates of the primary (nonfatal myocardial infarction, nonfatal stroke, cardiovascular disease (CVD) death) and other outcomes in the LEADER placebo group were compared with those in LEADER-eligible FDS2 participants during 3. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.005DOI Listing

Dethroning the king?: The future of metformin as first line therapy in type 2 diabetes.

J Diabetes Complications 2019 Mar 21. Epub 2019 Mar 21.

Tulane University, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.003DOI Listing
March 2019
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Body composition changes in diabetes and aging.

J Diabetes Complications 2019 Apr 3. Epub 2019 Apr 3.

Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, Baltimore, MD, United States of America. Electronic address:

Aging is associated with changes in body composition, including both fat gain and muscle loss beginning in middle age, and is associated with increased risk of type 2 diabetes. Moreover, changes in fat distribution take place in adults as they age and may contribute to the increased risk of type 2 diabetes. Recent literature has shown differences in the age-related changes in body composition by diabetes status suggesting that some of these changes might not only be a risk factor of the development of diabetes but could also be a consequence of the disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183143
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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.007DOI Listing
April 2019
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The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus: A comparison between the U.S. and Japan.

J Diabetes Complications 2019 Apr 1. Epub 2019 Apr 1.

Department of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Shiga, Japan.

Aims: To test a hypothesis that women with diabetes mellitus (DM) versus those without DM had a significantly higher risk of heart disease (HD), stroke and all-cause mortality than their male counterparts in the U.S. as well as in Japan. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.008DOI Listing
April 2019
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Bone mineral density in patients with longstanding type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes.

J Diabetes Complications 2018 Dec 22. Epub 2018 Dec 22.

Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:

Aim: It is currently unclear if longstanding type 1 diabetes (T1D) affects bone mineral density (BMD).

Methods: BMD measured by dual-energy X-ray absorptiometry and history of fragility fracture was determined in 75 T1D participants with ≥50 years of diabetes duration and 75 age- and sex-matched non-diabetic controls. BMD T-scores were determined for the lumbar spine (LS), total hip (TH) and femoral neck (FN). Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.009DOI Listing
December 2018
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Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.

J Diabetes Complications 2019 Mar 21. Epub 2019 Mar 21.

Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, United States. Electronic address:

Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.001DOI Listing

Fourth harmonic of radial pulse wave predicts adverse cardiac events in asymptomatic patients with type 2 diabetes.

J Diabetes Complications 2019 Apr 4. Epub 2019 Apr 4.

JinMu Health Technology, Taipei, Taiwan, ROC.

Aims: Studies have shown that the fourth harmonic of the radial pulse wave (C4) is associated with atherosclerotic processes and myocardial ischemia. We sought to investigate whether C4 is an independent predictor of adverse cardiac events (ACE).

Methods: The baseline C4 is calculated using the Fourier series method. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.002DOI Listing
April 2019
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Sex differences in the pathogenesis of type 2 diabetes may explain the stronger impact of diabetes on atherosclerotic heart disease in women.

J Diabetes Complications 2019 Apr 1. Epub 2019 Apr 1.

Section of Endocrinology & Metabolism, Department of Medicine, Tulane University Health Sciences Center and Veterans Health Care Administration Medical Center, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.006DOI Listing

Does an all-condition case management program for high-risk patients reduce health care utilization in medicaid and medicare beneficiaries with diabetes?

J Diabetes Complications 2019 Jan 22. Epub 2019 Jan 22.

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Objective: To assess whether an all-condition case management program can improve health care utilization and clinical outcomes in patients with diabetes.

Research Design And Methods: 1342 patients with diabetes were enrolled in the Johns Hopkins Community Health Partnership (J-CHiP) Case Management program for high-risk patients with any chronic disease. We categorized participants into two intervention exposure categories based on the number of contacts with case manager (CM) and community health worker (CHW) per month: low contact (≤1 contact/month), and high contact (>1 contacts/month). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183049
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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.011DOI Listing
January 2019
2 Reads

Corrigendum to Intensive glycemic control in younger and older U.S. adults with type 2 diabetes [JDC 31 (2017) 1299-1304].

J Diabetes Complications 2019 May;33(5):406

National Institute of Diabetes and Digestive and Kidney Diseases.

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http://dx.doi.org/10.1016/j.jdiacomp.2019.03.004DOI Listing
May 2019
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Perfluoroalkyl substances are inversely associated with coronary heart disease in adults with diabetes.

J Diabetes Complications 2019 Feb 20. Epub 2019 Feb 20.

Department of Epidemiology, West Virginia University, Morgantown, WV, USA; Department of Community Health, University of Texas Health Science Center at Tyler, Tyler, TX, USA. Electronic address:

Aims: Perfluoroalkyl substances (PFAS) are environmentally and biologically persistent synthetic environmental contaminants linked to adverse health outcomes. Though null to modest inverse relationships between PFAS and coronary heart disease (CHD) have been reported, studies regarding relationships in high risk populations such as those with diabetes are sparse. We investigated the relationship of PFAS with CHD in persons with diabetes. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.02.004DOI Listing
February 2019
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Diabetes-related hospital mortality in the U.S.: A pooled cross-sectional study of the National Inpatient Sample.

J Diabetes Complications 2019 May 23;33(5):350-355. Epub 2019 Feb 23.

Department of Health Policy and Management, School of Public Health, Texas A&M University, College Station, TX, United States of America; Southwest Rural Health Research Center, School of Public Health, Texas A&M University, College Station, TX, United States of America.

Aims: Despite advancements in the diagnosis and treatment of diabetes in the U.S., place-based disparities still exist. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.007DOI Listing

Is hyperfiltration associated with higher urine albumin-to-creatinine ratio at follow up among Indigenous Australians? The eGFR follow-up study.

J Diabetes Complications 2019 May 21;33(5):343-349. Epub 2019 Feb 21.

Menzies School of Health Research, Charles Darwin University, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia. Electronic address:

Background: Glomerular hyperfiltration is not able to be detected in clinical practice. We assessed whether hyperfiltration is associated with albuminuria progression among Indigenous Australians at high risk of diabetes and kidney disease to determine its role in kidney disease progression.

Methods: Longitudinal observational study of Indigenous Australians aged ≥18 years recruited from >20 sites, across diabetes and/or kidney function strata. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.02.005DOI Listing
May 2019
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Fasting glucose and insulin resistance trajectories during young adulthood and mid-life cardiac structure and function.

J Diabetes Complications 2019 May 6;33(5):356-362. Epub 2019 Feb 6.

Northwestern University, Chicago, IL, United States of America.

Aims: We assessed whether fasting glucose (FG) and insulin resistance (IR) trajectories during young adulthood are associated with changes in cardiac structure and function.

Methods: We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study (baseline: 1985-1986). Echocardiography was performed after 25 (Y25) and 30 years of follow-up. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451883PMC
May 2019
1 Read

Risk factors for readmission of inpatients with diabetes: A systematic review.

J Diabetes Complications 2019 May 30;33(5):398-405. Epub 2019 Jan 30.

Institute of Digital Healthcare, WMG, University of Warwick, Coventry CV4 7AL, United Kingdom.

Aim: We have limited understanding of which risk factors contribute to increased readmission rates amongst people discharged from hospital with diabetes. We aim to complete the first review of its kind, to identify, in a systematic way, known risk factors for hospital readmission amongst people with diabetes, in order to better understand this costly complication.

Method: The review was prospectively registered in the PROSPERO database. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.004DOI Listing
May 2019
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Hyperglycemia inhibition of endothelial miR-140-3p mediates angiogenic dysfunction in diabetes mellitus.

J Diabetes Complications 2019 May 10;33(5):374-382. Epub 2019 Feb 10.

Department of Clinical Laboratory, The 3rd People's Hospital of Qingdao, Qingdao 266041, Shandong Province, China. Electronic address:

Objective: MicroRNAs (miRNAs) have emerged as promising regulators of diabetes mellitus (DM)-induced angiogenic dysfunction in endothelial cells (ECs), but information vis-à-vis the functional roles of distinct miRNAs remain surprisingly scarce. The current study was designed to elucidate the expression and function of miR-140-3p in diabetic ECs.

Methods: miR-140-3p expression was evaluated in DM mouse model and in human ECs using RT-qPCR, Northern blot and RNA fluorescent in situ hybridization. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.02.001DOI Listing

Insulin treatment affects leukocyte telomere length in patients with type 2 diabetes: 6-year longitudinal study.

J Diabetes Complications 2019 May 12;33(5):363-367. Epub 2019 Feb 12.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China. Electronic address:

Objective: Many studies demonstrated a close relationship between type 2 diabetes mellitus (T2DM) and leukocyte telomere length (LTL). However, how the LTL changes in T2DM and what are the potential causal factors in it, particularly in patients during a long period treatment, have not been studied. Here we performed a longitudinal observation of LTL in trained T2DM patients during a 6-year follow-up and evaluated the possible risk factors that were associated with LTL alteration. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.02.003DOI Listing
May 2019
2 Reads
1.925 Impact Factor

Undiagnosed coronary artery disease in long-term type 1 diabetes. The Dialong study.

J Diabetes Complications 2019 May 31;33(5):383-389. Epub 2019 Jan 31.

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; The Norwegian Diabetics' Center, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Aims: We studied the total prevalence of obstructive coronary artery disease (CAD), undiagnosed CAD and absent CAD in persons with ≥45-year duration of type 1 diabetes (T1D) versus controls, and associations with mean HbA, LDL-cholesterol and blood pressure over 2-3 decades.

Methods: We included 76% (n = 103) of all persons with T1D diagnosed ≤1970 attending a diabetes center and 63 controls without diabetes. We collected 20-30 years of HbA, LDL-cholesterol and blood pressure measurements. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.006DOI Listing
May 2019
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Serial renal biopsies in normo- and microalbuminuric patients with type 2 diabetes demonstrate that loss of renal function is associated with a reduction in glomerular filtration surface secondary to mesangial expansion.

J Diabetes Complications 2019 May 10;33(5):368-373. Epub 2019 Feb 10.

Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan.

Aims: The aim of the present study was to explore the relationship between changes in renal structure in patients with type 2 diabetes at an early stage of diabetic nephropathy using serial renal biopsies, and change in renal function.

Methods: The study population comprised 10 patients with type 2 diabetes with normo- or microalbuminuria at baseline. Light and electron microscopy-based morphometric analyses were performed to quantitatively evaluate glomerular and interstitial structural changes. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.02.002DOI Listing
May 2019
6 Reads

Lower serum osteocalcin concentrations in patients with type 2 diabetes and relationships with vascular risk factors among patients with coronary artery disease.

J Diabetes Complications 2019 May 17;33(5):390-397. Epub 2019 Jan 17.

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada; Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, Canada; University Health Network Toronto Rehabilitation Institute, Toronto, Canada. Electronic address:

Background: Lower serum concentrations of the osteoblast-derived protein, osteocalcin, have been associated with poorer glycemic control, insulin resistance and atherosclerosis, and with the development of type 2 diabetes (T2DM).

Methods: This study compares concentrations of two physiological forms of osteocalcin, carboxylated (cOCN) and uncarboxylated (unOCN), between participants with T2DM (n = 20) and age-, gender- and body mass index (BMI)-matched participants without T2DM (n = 40) among patients with coronary artery disease (CAD), and it explores relationships between osteocalcin concentrations and cardiovascular risk factors.

Results: Concentrations of unOCN (2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183131
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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.003DOI Listing
May 2019
6 Reads

The association of glycated hemoglobin with mortality and ESKD among persons with diabetes and chronic kidney disease.

J Diabetes Complications 2019 Apr 7;33(4):296-301. Epub 2019 Jan 7.

Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:

Context: Diabetic kidney disease (DKD) is the leading cause of end stage kidney disease (ESKD) and is associated with a considerably shortened lifespan. While glucose-lowering therapy targeting glycated hemoglobin (HbA1c) <7% is proven to reduce the risk of developing DKD, its effects on complications of DKD are unclear.

Objective: We examined the associations of HbA1c with risks of progression to ESKD and death within a clinic-based study of CKD. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411440PMC

Liraglutide prevents β-cell apoptosis via inactivation of NOX2 and its related signaling pathway.

J Diabetes Complications 2019 Apr 2;33(4):267-277. Epub 2019 Jan 2.

NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin 300070, PR China. Electronic address:

Aims: High glucose (HG)-induced pancreatic β-cell apoptosis may be a major contributor to the progression of diabetes mellitus (DM). NADPH oxidase (NOX2) has been considered a crucial regulator in β-cell apoptosis. This study was designed to evaluate the impact of GLP-1 receptor agonist (GLP-1Ra) liraglutide on pancreatic β-cell apoptosis in diabetes and the underlying mechanisms involved. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.013DOI Listing
April 2019
1 Read

Obesity, visceral adiposity and carotid atherosclerosis.

J Diabetes Complications 2019 Apr 17;33(4):302-306. Epub 2019 Jan 17.

Department of Cardiology, School of Health Sciences, Medical University of Silesia, Katowice, Poland.

Carotid artery atherosclerosis is a complex and multifactorial chronic disease. Our aim was to assess the associations between obesity, fat depots and carotid artery stenosis (CAS) in patients with high cardiovascular (CV) risk.

Methods: The study group included 391 patients (F/M: 136/255 pts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.002DOI Listing
April 2019
1 Read

Role of sex in post-transplant diabetes mellitus development: Are men and women equal?

J Diabetes Complications 2019 Apr 4;33(4):315-322. Epub 2019 Jan 4.

Ist Department of Internal Diseases, University Hospital Martin and Jessenius Medical Faculty of Comenius University, Slovak Republic.

Introduction: Sex differences are defined as biology-linked differences between women and men that occur through the sex chromosomes and their effects on organ systems.

Material And Methods: The objective of this prospective study was to determine risk factors for post-transplant diabetes mellitus (PTDM) in men and women.

Results: A total of 417 patients (271 men and 146 women) were included in the monitored group. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.017DOI Listing
April 2019
8 Reads

Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes.

J Diabetes Complications 2019 Apr 4;33(4):323-328. Epub 2019 Jan 4.

Department of Clinical Medicine, Aalborg University, Søndre Skovvej 11, 9000 Aalborg, Denmark; Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

Aims: Emerging evidence shows, that distal symmetric peripheral neuropathy (DSPN) also involves alterations in the central nervous system. Hence, the aims were to investigate brain metabolites in white matter of adults with diabetes and DSPN, and to compare any cerebral disparities with peripheral nerve characteristics.

Methods: In type 1 diabetes, brain metabolites of 47 adults with confirmed DSPN were compared with 28 matched healthy controls using proton magnetic resonance spectroscopy (H-MRS) in the parietal region including the sensorimotor fiber tracts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.016DOI Listing
April 2019
1 Read

Understanding the importance of Food Insecurity among populations with diabetes.

Authors:
Candice A Myers

J Diabetes Complications 2019 Apr 22;33(4):340-341. Epub 2018 Dec 22.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address:

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The longitudinal relationship between food insecurity in older adults with diabetes and emergency department visits, hospitalizations, hemoglobin A1c, and medication adherence.

J Diabetes Complications 2019 Apr 6;33(4):289-295. Epub 2018 Dec 6.

Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO, United States; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Aims: To examine the relationship between food insecurity and emergency department (ED) visits, hospitalizations, A1c, and diabetes medication adherence over one year of follow-up among individuals >65 years with diabetes mellitus.

Methods: We conducted a longitudinal cohort study of adults >65 years with diabetes who did (n = 742) or did not (n = 2226) report food insecurity at baseline. We used conditional logistic regression for the ED visits or hospitalization outcomes, and mixed effects models for A1c and non-insulin diabetes medication adherence. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.011DOI Listing
April 2019
2 Reads

Impact of diabetes and hyperglycemia on health care utilization, infection risk, and survival in patients with cancer receiving glucocorticoids with chemotherapy.

J Diabetes Complications 2019 Apr 3;33(4):335-339. Epub 2019 Jan 3.

International Diabetes Center, Park Nicollet, Minneapolis, MN, USA.

Background: Glucocorticoids are commonly used in chemotherapy regimens and may lead to hyperglycemia and increased infection rates.

Methods: We performed a retrospective analysis on 1781 patients who received intravenous chemotherapy with glucocorticoids between 2010 and 2015. Data was obtained using electronic medical record, billing modules, and tumor registry. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.012DOI Listing
April 2019
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Identifying solutions to psychological insulin resistance: An international study.

J Diabetes Complications 2019 Apr 17;33(4):307-314. Epub 2019 Jan 17.

Eli Lilly and Company, Indianapolis, IN, USA.

Aims: To identify actions of healthcare professionals (HCPs) that facilitate the transition to insulin therapy (IT) in type 2 diabetes (T2D) adults.

Methods: Included were T2Ds in seven countries (n = 594) who reported initial IT reluctance but eventually began IT. An online survey included 38 possible HCP actions: T2Ds indicated which may have occurred and their helpfulness. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.001DOI Listing
April 2019
1 Read

Stress hyperglycemia: A prospective study examining the relationship between glucose, cortisol and diabetes in myocardial infarction.

J Diabetes Complications 2019 Apr 4;33(4):329-334. Epub 2019 Jan 4.

Dept of Diabetes & Endocrinology, Blacktown Hospital, Blacktown 2148, Australia; Western Sydney University, Penrith, NSW 2751, Australia. Electronic address:

Aim: We aimed to explore the relationship between stress, hyperglycemia and diabetes in myocardial infarction (MI), using serum cortisol as a surrogate marker for the severity of stress.

Methods: Subjects with acute MI were prospectively recruited upon hospital admission. Serum glucose and cortisol were measured in addition to standard testing. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.015DOI Listing
April 2019
2 Reads

Lower cardiovagal tone and baroreflex sensitivity associated with hepatic insulin resistance and promote cardiovascular disorders in Tibetan minipigs induced by a high fat and high cholesterol diet.

J Diabetes Complications 2019 Apr 4;33(4):278-288. Epub 2019 Jan 4.

Comparative Medical Research Institute, Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address:

Aims: A long-term high-fat/cholesterol (HFC) diet leads to hepatic insulin resistance (IR), which is associated with autonomic dysfunction and cardiovascular diseases risk increasing. However, whether this occurs in Tibetan minipigs remains unknown. We tested that a long-term HFC diet caused hepatic IR and promote cardiovascular disorders in Tibetan minipigs, and are associated with the reduction of cardiovagal tone and baroreflex sensitivity (BRS). Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.014DOI Listing
April 2019
1 Read

Challenging the conventional wisdom on diabetic nephropathy: Is microalbuminuria the earliest event?

J Diabetes Complications 2019 Mar 14;33(3):191-192. Epub 2018 Dec 14.

Tulane University Health Sciences Center, New Orleans, LA 70112, United States of America; Southeast Louisiana Veterans Health Care System, New Orleans, LA 70112, United States of America.

Microalbuminuria, urine albumin-to-creatinine ratio >30 and less than <300 mg/g has widely been accepted as biomarker of early diabetic kidney disease (DKD). Based on absence of beta-2 microglobulinuria in earlier studies on microalbuminuria, its possible tubular origin has been dismissed. Microalbuminuria has been assumed as a marker of endothelial injury. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.006DOI Listing
March 2019
3 Reads

Altered responses to pneumococcal vaccination in an elderly diabetic Japanese vaccine trial: The risk of concurrent vaccination strategies.

J Diabetes Complications 2019 Mar 21;33(3):189-190. Epub 2018 Dec 21.

Department of Microbiology & Immunology, Tulane University School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.007DOI Listing
March 2019
8 Reads

Nutrigenetic effects in metabolic syndrome - A cornerstone for individualized therapy.

Authors:
Stefan Kabisch

J Diabetes Complications 2019 Mar 28;33(3):193-194. Epub 2018 Nov 28.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany; German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung e.V.; DZD), Geschäftsstelle am Helmholtz-Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.008DOI Listing
March 2019
1 Read

The effect of structured personal care on RNA oxidation: A 19-year follow-up of the randomized trial Diabetes Care in General Practice (DCGP).

J Diabetes Complications 2019 Mar 11;33(3):202-207. Epub 2018 Dec 11.

Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims: The urinary marker of RNA oxidation, 8‑oxo‑7,8‑dihydroguanosine (8-oxoGuo), but not the corresponding marker of DNA oxidation, 8‑oxo‑7,8‑dihydro‑2'‑deoxyguanosine (8-oxodG), is a prognostic biomarker in patients with type 2 diabetes (T2D). The aim of the present study was to investigate the effect of structured personal care (individualized multifactorial treatment) versus standard care on RNA oxidation level in patients with T2D and to assess if the effect of structured personal care on all-cause and diabetes-related mortality was modified by RNA oxidation level.

Methods: Urine samples were analyzed for 8-oxoGuo/8-oxodG from 1381 newly diagnosed T2D patients from the cluster randomized trial Diabetes Care in General Practice cohort, and 970 patients were reexamined after six years of intervention. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.004DOI Listing
March 2019
1 Read

Analysis of sphingolipid composition in human vitreous from control and diabetic individuals.

J Diabetes Complications 2019 Mar 14;33(3):195-201. Epub 2018 Dec 14.

The University of Tennessee Health Science Center, Department of Ophthalmology, Memphis, TN 38163, USA; The University of Tennessee Health Science Center, Department of Anatomy and Neurobiology, Memphis, TN 38163, USA; The University of Oklahoma Health Science Center, Department of Ophthalmology, Oklahoma City, OK 73104, USA. Electronic address:

Objective: Sphingolipids have a fundamental role in many cellular processes, and they have been implicated in insulin resistance and Diabetes Mellitus (DM) and its complications, including diabetic retinopathy (DR). Little is known about how bioactive sphingolipids relate to retinopathies in human DM. In this study, we analyzed the sphingolipid composition of type 2 diabetic (T2DM) and non-diabetic human vitreous samples. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368445PMC
March 2019
11 Reads

Patient-reported barriers and outcomes associated with poor glycaemic and blood pressure control in co-morbid diabetes and chronic kidney disease.

J Diabetes Complications 2019 Jan 12;33(1):63-68. Epub 2018 Oct 12.

School of Public Health and Preventive Medicine, Monash University, VIC, Australia; Diabetes and Vascular Medicine Unit, Monash Health, VIC, Australia; The George Institute for Global Health, NSW, Australia. Electronic address:

Aims: In patients with comorbid diabetes and chronic kidney disease, the extent to which patient-reported barriers to health-care and patient reported outcomes influence the quality of health care is not well established. This study explored the association between patient-reported barriers to health-care, patient activation, quality of life and diabetes self-care, with attainment of glycaemic and blood pressure (BP) targets.

Methods: This cross-sectional study recruited adults with diabetes and CKD (eGFR 20 to <60 ml/min/1. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.020DOI Listing
January 2019
11 Reads
1.925 Impact Factor

Exploratory metabolomics of nascent metabolic syndrome.

J Diabetes Complications 2019 Mar 10;33(3):212-216. Epub 2018 Dec 10.

California North-state University College of Medicine, United States of America. Electronic address:

Introduction: Metabolic syndrome (MetS) is a disorder defined by having three of five features: increased waist circumference (WC), hypertriglyceridemia, decreased high-density lipoprotein-cholesterol, hypertension and an elevated blood glucose (BG). Metabolic Syndrome ( MetS) affects 35% of American adults and significantly increases risk for Atherosclerotic cardiovascular disease (ASCVD) and type-2 diabetes (T2DM). An understanding of the metabolome will help elucidate the pathogenesis of MetS and lead to better management. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.002DOI Listing
March 2019
4 Reads

Efficacy and tolerability of exenatide once weekly over 7 years in patients with type 2 diabetes: An open-label extension of the DURATION-1 study.

J Diabetes Complications 2019 Mar 5;33(3):223-230. Epub 2018 Dec 5.

AstraZeneca, Gaithersburg, MD, USA.

Aims: To investigate the glycemic efficacy, effects on cardiovascular risk factors, and safety of exenatide once weekly (QW) in patients with type 2 diabetes over 7 years in the DURATION-1 study.

Methods: Patients were initially randomized to exenatide QW 2 mg or exenatide twice daily for 30 weeks, after which they received open-label, open-ended treatment with exenatide QW 2 mg for up to 7 years. Efficacy analyses included changes from baseline in glycated hemoglobin (HbA) and cardiovascular risk factors. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.012DOI Listing
March 2019
2 Reads

Efficacy and safety of insulin glargine/lixisenatide (iGlarLixi) fixed-ratio combination in older adults with type 2 diabetes.

J Diabetes Complications 2019 Mar 30;33(3):236-242. Epub 2018 Nov 30.

National Research Institute, 2010 Wilshire Blvd #302, Los Angeles, 90057, CA, USA. Electronic address:

Aims: This study assessed the efficacy and safety of iGlarLixi (a titratable, fixed-ratio combination of insulin glargine [iGlar] plus lixisenatide) in older patients with type 2 diabetes.

Methods: This post hoc analysis used patient-level data from patients aged ≥65 years from the phase III LixiLan-O and LixiLan-L studies, which compared iGlarLixi with iGlar and lixisenatide (LixiLan-O only). Efficacy endpoints were changes in glycated hemoglobin A1C, fasting plasma glucose, postprandial glucose, weight, and achievement of A1C <7. Read More

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March 2019
5 Reads

Depressive symptom dimensions and medication non-adherence in suboptimally controlled type 2 diabetes.

J Diabetes Complications 2019 Mar 7;33(3):217-222. Epub 2018 Dec 7.

Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA; Department of Medicine (Endocrinology), Albert Einstein College of Medicine, Bronx, NY, USA; The Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, NY, USA.

Aims: Research suggests differential effects for somatic and cognitive-affective depressive symptoms in predicting health outcomes. This study evaluated differential relations with medication non-adherence among disadvantaged, and predominantly immigrant adults with sub-optimally controlled type 2 diabetes (T2D).

Methods: Health plan members taking oral diabetes medication and who had A1c ≥ 7. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.001DOI Listing
March 2019
3 Reads

Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis.

J Diabetes Complications 2019 Mar 8;33(3):208-211. Epub 2018 Dec 8.

Department of Internal Medicine, Brothers of Mercy Hospital, Brno, Czech Republic; 2nd Department of Surgery, Faculty of Medicine, St. Anne's University Hospital, Brno, Czech Republic. Electronic address:

Purpose: The aim of this work was to study the association of serum ionized calcium with retinal photoreceptor apoptosis on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR).

Methods: Sixty consecutive cases with Type 2 diabetes mellitus were categorized into three groups: no diabetic retinopathy; non-proliferative DR; proliferative DR. The eye with more severe form of the disease was considered. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.003DOI Listing
March 2019
3 Reads

1,5 Anhydroglucitol in gestational diabetes mellitus.

J Diabetes Complications 2019 Mar 5;33(3):231-235. Epub 2018 Dec 5.

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, ICMR Centre for Advanced Research on Diabetes, Gopalapuram, Chennai, India. Electronic address:

Objective: 1,5 Anhydroglucitol (1,5 AG) is reported to be a more sensitive marker of glucose variability and short-term glycemic control (1-2 weeks) in patients with type1 and type 2 diabetes. However, the role of 1,5 AG in gestational diabetes mellitus (GDM) is not clear. We estimated the serum levels of 1,5 AG in pregnant women with and without GDM. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.010DOI Listing
March 2019
2 Reads

Altered immunogenicity of 23-valent pneumococcal polysaccharide vaccine in elderly patients with diabetes who revealed lower responses to concomitant administration of BIKEN varicella zoster vaccine: Results of post hoc analysis of a randomized double-blind trial.

J Diabetes Complications 2019 Mar 22;33(3):243-248. Epub 2018 Nov 22.

Department of Hygiene and Public Health, Teikyo University School of Medicine, 2-11-1 Kaga Itabashi-ku, Tokyo 173-8605, Japan.

Aims: This double-blind randomized controlled study of 52 elderly patients with diabetes assessed cell-mediated immunity and safety of BIKEN varicella-zoster vaccine (BVZV). Cellular and humoral responses to VZV at 3 months after BVZV and 23-valent polysaccharide pneumococcal vaccine (PPSV23) vaccination elicited poor results. Post-hoc analyses assessed the effects of immunogenicity of PPSV23. Read More

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March 2019
1 Read

Potential role of E4orf1 protein in aging-associated impairment in glycemic control.

J Diabetes Complications 2019 Mar 22;33(3):261-265. Epub 2018 Nov 22.

Obesity and Metabolic Health Laboratory, Nutritional Sciences Department, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

Aging constitutes a major risk factor for the development of type-2 diabetes (T2D) where glucose tolerance declines with age, resulting in a high prevalence of T2D and impaired glucose tolerance in the elderly population. Currently more than half of the 20 million U.S. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.006DOI Listing
March 2019
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An investigation into the durability of glycemic control in patients with type II diabetes initiated on canagliflozin or sitagliptin: A real-world analysis of electronic medical records.

J Diabetes Complications 2019 Feb 31;33(2):140-147. Epub 2018 Oct 31.

Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA. Electronic address:

Aims: The aims of this study were to assess glycemic control, weight loss, and durability of glycemic control in patients initiated on canagliflozin (CANA) versus sitagliptin (SITA).

Methods: Adults with type II diabetes mellitus initiated on CANA or SITA (index date) were identified from IQVIA™ Real-World Data Electronic Medical Records - US database (03/29/2012-04/30/2016). Inverse probability of treatment weighting accounted for baseline differences between cohorts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.016DOI Listing
February 2019
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Epidermal growth factor receptor and podocin predict nephropathy progression in type 2 diabetic patients through interaction with the autophagy influencer ULK-1.

J Diabetes Complications 2019 Feb 22;33(2):128-133. Epub 2018 Nov 22.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Aims: Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.007DOI Listing
February 2019
15 Reads

Sex differences in the association of psychosocial resources with prevalent type 2 diabetes among African Americans: The Jackson Heart Study.

J Diabetes Complications 2019 Feb 22;33(2):113-117. Epub 2018 Nov 22.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Aim: To examine the association of psychosocial resources with prevalent type 2 diabetes (T2D) in 5104 African American men and women.

Methods: Using data from the Jackson Heart Study (JHS), we evaluated the cross-sectional associations of four psychosocial resources (social support, optimism, religiosity, and social networks) with T2D [fasting glucose ≥126 mg/dL, or HbA1c ≥ 6.5%, or use of diabetic medication]. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.005DOI Listing
February 2019
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Gestational diabetes mellitus alters DNA methylation profiles in pancreas of the offspring mice.

J Diabetes Complications 2019 Jan 9;33(1):15-22. Epub 2018 Nov 9.

Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China; Department of Scientific Research, Fujian Academy of Medical Sciences, Fuzhou, Fujian, China. Electronic address:

Gestational diabetes mellitus (GDM), which has an increasing global prevalence, contributes to the susceptibility to metabolic dysregulation and obesity in the offspring via epigenetic modifications. However, the underlying mechanism remains largely obscure. The current study established a GDM mice model to investigate the alternations in the metabolic phenotypes and genomic DNA methylation in the pancreas of the offspring. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.002DOI Listing
January 2019
1 Read
1.925 Impact Factor