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Impact of Deployment on Reproductive Health in U.S. Active-Duty Servicewomen and Veterans.

Semin Reprod Med 2018 Nov 19;36(6):361-370. Epub 2019 Apr 19.

Informatics, Decision Enhancement, and Analytic Sciences (IDEAS) Center, VA Salt Lake City Health Care System, Salt Lake City, Utah.

Reproductive-age women are a fast-growing component of active-duty military personnel who experience deployment and combat more frequently than previous service-era women Veterans. With the expansion of the number of women and their roles, the United States Departments of Defense and Veterans Affairs have prioritized development and integration of reproductive services into their health systems. Thus, understanding associations between deployments or combat exposures and short- or long-term adverse reproductive health outcomes is imperative for policy and programmatic development. Read More

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http://dx.doi.org/10.1055/s-0039-1678749DOI Listing
November 2018

The Department of Defense Birth and Infant Health Research Program: Assessing the Reproductive Health of U.S. Active-Duty Women.

Semin Reprod Med 2018 Nov 19;36(6):351-360. Epub 2019 Apr 19.

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland.

As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies to assess potential increased risks for adverse reproductive and infant health outcomes in the military population. Military personnel endure unique physical and mental demands as a part of their occupational duties (e. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678751
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November 2018
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The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen.

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

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November 2018
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Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018

Assisted Reproductive Technology and the Reproductive Endocrinology and Infertility Specialist in the U.S. Military.

Semin Reprod Med 2018 Nov 19;36(6):323-326. Epub 2019 Apr 19.

Walter Reed National Military Medical Center, Bethesda, Maryland.

The U.S. military mirrors the U. Read More

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http://dx.doi.org/10.1055/s-0039-1681084DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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November 2018
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Reproductive Health Needs of the Military and Veterans: Part 1.

Semin Reprod Med 2018 Nov 19;36(6):313-314. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

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http://dx.doi.org/10.1055/s-0039-1683423DOI Listing
November 2018

Alicia Y. Christy, MD, MHSCR, FACOG and Richard Burney, MD, MSc.

Authors:
James H Segars

Semin Reprod Med 2018 Nov 19;36(6):311-312. Epub 2019 Apr 19.

Division of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1055/s-0039-1683914DOI Listing
November 2018

Examining Performance on a Process-Based Assessment of Word Learning in Relation to Vocabulary Knowledge and Learning in Vocabulary Intervention.

Semin Speech Lang 2019 Apr 19. Epub 2019 Apr 19.

Department of Communication Sciences and Disorders at the University of South Florida, Tampa, Florida.

Vocabulary knowledge of young children, as a well-established predictor of later reading comprehension, is an important domain for assessment and intervention. Standardized, knowledge-based measures are commonly used by speech-language pathologists (SLPs) to describe existing vocabulary knowledge and to provide comparisons to same-age peers. Process-based assessments of word learning can be helpful to provide information about how children may respond to learning opportunities and to inform treatment decisions. Read More

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http://dx.doi.org/10.1055/s-0039-1688447DOI Listing

Oxygen Saturation and Perfusion Index-Based Enhanced Critical Congenital Heart Disease Screening.

Am J Perinatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, University of California, Davis, Sacramento, California.

Objective:  To determine if addition of perfusion index (PIx) to oxygen saturation (SpO) screening improves detection of critical congenital heart disease (CCHD) with systemic outflow obstruction.

Study Design:  We determined screening thresholds for PIx and applied these to a cohort of newborns with and without congenital heart disease (CHD).

Results:  A total of 123 normal and 21 CHD newborns (including five with critical systemic outflow obstruction) were enrolled. Read More

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April 2019
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Common and Uncommon Variations of Pulmonary Venous Drainage in Patients Undergoing Thoracoscopic Lobectomy.

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Monaldi Hospital, Naples, Italy.

Background:  Variations in pulmonary venous anatomy should not be undermined by thoracic surgeons during procedures which involve the pulmonary veins.

Methods:  We have identified vascular anomalies in 25 of 346 patients undergoing video-assisted thoracoscopic surgery lobectomy at our Thoracic Surgery Unit, between December 2016 and November 2018.

Results:  Some vascular anomalies described have not been reported in recent literature and include right V draining into the middle lobe pulmonary vein, accessory right V behind the bronchus intermedius, two V from the apical segment of left lower lobe, two V from the apical segment of right lower lobe, and one of them draining into the superior pulmonary vein. Read More

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http://dx.doi.org/10.1055/s-0039-1684000DOI Listing

Intermediate Outcomes after Rapid Deployment Aortic Valve Replacement in Multiple Valve Surgery.

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Berufsgenossenschaftliches Universitatsklinikum Bergmannsheil - Klinik für Herz- und Thoraxchirurgie, Bochum, Nordrhein-Westfalen, Germany.

Background:  Multiple valve surgery is associated with significant higher operative risks. Reduced cross-clamp and cardiopulmonary bypass times in multiple valve surgery may potentially be beneficial as they can be considered independent risk factors for increased morbidity and mortality following cardiac surgery. We report first intermediate outcomes of the Edwards Intuity valve system (Edwards Lifesciences, Irvine, California, United States) in combined procedures METHODS:  Fifty-eight patients underwent rapid deployment aortic valve replacement with concomitant mitral valve surgery between January 2014 and November 2017 in our institution. Read More

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http://dx.doi.org/10.1055/s-0039-1685178DOI Listing

Outcome of a Modified Perceval Implantation Technique.

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background:  In our institution, we developed a modification of the standard implantation technique of the Perceval sutureless aortic prosthesis (LivaNova, London, United Kingdom) that involves the usage of snuggers for the guiding sutures during valve deployment. The technique has been described elsewhere. In this article, we present the results of our initial case series comprising 128 consecutive patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685512
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http://dx.doi.org/10.1055/s-0039-1685512DOI Listing
April 2019
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Placental programming of neuropsychiatric disease.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Division of Neonatology, Children's Research Institute at Children's National Medical Center, Washington, DC, USA.

The placenta is vital for fetal growth, and compromised function is associated with abnormal development, especially of the brain. Linking placental function to brain development is a new field we have dubbed neuroplacentology. Approximately 380,000 infants in the United States each year abruptly lose placental support upon premature birth, and more than 10% of pregnancies are affected by more insidious placental dysfunction such as preeclampsia or infection. Read More

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http://dx.doi.org/10.1038/s41390-019-0405-9DOI Listing

Observed and calculated cerebral critical closing pressure are highly correlated in preterm infants.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

Introduction: Cerebrovascular critical closing pressure (CrCP) is the arterial blood pressure (ABP) at which cerebral blood flow ceases. Preterm ABP is low and close to CrCP. The diastolic closing margin (diastolic ABP minus CrCP) has been associated with intraventricular hemorrhage in preterm infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0403-yDOI Listing

Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China.

Backgrounds: Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.

Methods: A case-control study with 1092 Chinese children was conducted.

Results: We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (P = 0. Read More

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http://dx.doi.org/10.1038/s41390-019-0402-zDOI Listing

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Neuropsychopharmacology 2019 Apr 19. Epub 2019 Apr 19.

Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.

Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dysregulated eating and its evolving pathogenesis. The medial prefrontal cortex (mPFC) is a major neural director of reward-driven behavior and impulsivity. Read More

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http://dx.doi.org/10.1038/s41386-019-0394-8DOI Listing

Conservative Management and Rehabilitation in the Older Runner With Knee Osteoarthritis: An Evidence-Based Review.

Am J Phys Med Rehabil 2019 May;98(5):416-421

From the Physical Medicine and Rehabilitation Department, MossRehab, Elkins Park, Pennsylvania (BC); and Physical Medicine, Rehabilitation and Sports Medicine Department, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico (FS, WM).

Osteoarthritis is an age-related condition that commonly affects the middle-aged and elderly population including individuals who continue to pursue an active and athletic lifestyle. Running is an easily accessible activity with many health benefits; thus, it is becoming a popular form of exercise, even in older individuals. Studies evaluating the correlation between running and osteoarthritis show conflicting results; however, most studies show an increased risk of osteoarthritis in runners with a combination of modifiable and nonmodifiable risk factors. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001082DOI Listing

Optimal Muscle Selection for OnabotulinumtoxinA Injections in Poststroke Lower-Limb Spasticity: A Randomized Trial.

Am J Phys Med Rehabil 2019 May;98(5):360-368

From the MossRehab Gait and Motion Analysis Laboratory, Elkins Park, Pennsylvania (AE); McGill University, Division of Neurology, Montreal General Hospital, Montreal, Quebec, Canada (THW); Staffordshire University, Faculty of Health and North Staffordshire Rehabilitation Centre, Haywood Hospital, Stoke-on-Trent, United Kingdom (ABW); Halifax Health, Brooks Rehabilitation, Daytona Beach, Florida (CG); Allergan plc, Bridgewater, New Jersey (CL); and Allergan plc, Irvine, California (RD).

Objective: The aim of the study was to identify optimal muscle selection patterns for onabotulinumtoxinA treatment of poststroke lower-limb spasticity.

Design: Adults with poststroke lower-limb spasticity (ankle Modified Ashworth Scale ≥3) were randomized to onabotulinumtoxinA (300 U, mandatory ankle plantar flexors; ≤100 U, optional lower-limb muscles) or placebo. Post hoc analysis assessed the impact of muscle selection patterns on ankle Modified Ashworth Scale and physician-assessed Clinical Global Impression of Change based on change from baseline to average of weeks 4/6 versus placebo. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001101DOI Listing
May 2019
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The widespread increase in inter-individual variability of gene expression in the human brain with age.

Aging (Albany NY) 2019 Apr 19. Epub 2019 Apr 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.

Aging is broadly defined as a time-dependent progressive decline in the functional and physiological integrity of organisms. Previous studies and evolutionary theories of aging suggest that aging is not a programmed process but reflects dynamic stochastic events. In this study, we test whether transcriptional noise shows an increase with age, which would be expected from stochastic theories. Read More

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http://dx.doi.org/10.18632/aging.101912DOI Listing

Variation in hospital charges in patients with external ventricular drains: comparison between the intensive care and surgical floor settings.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

3Department of Neurosurgery, University of Washington School of Medicine, Seattle, Washington.

OBJECTIVEPlacement of an external ventricular drain (EVD) is a common and potentially life-saving neurosurgical procedure, but the economic aspect of EVD management and the relationship to medical expenditure remain poorly studied. Similarly, interinstitutional practice patterns vary significantly. Whereas some institutions require that patients with EVDs be monitored strictly within the intensive care unit (ICU), other institutions opt primarily for management of EVDs on the surgical floor. Read More

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http://dx.doi.org/10.3171/2019.2.PEDS18545DOI Listing
April 2019
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Hydrocephalus-induced neurogenic stunned myocardium and cardiac arrest in a child: completely reversed with CSF diversion.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

Neurogenic stunned myocardium (NSM) is a potentially fatal cause of sudden cardiogenic dysfunction due to an acute neurological event, most commonly aneurysmal subarachnoid hemorrhage in adults. Only two pediatric cases of hydrocephalus-induced NSM have been reported. Here the authors report a third case in a 14-year-old boy who presented with severe headache, decreased level of consciousness, and shock in the context of acute hydrocephalus secondary to fourth ventricular outlet obstruction 3 years after standard-risk medulloblastoma treatment. Read More

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http://dx.doi.org/10.3171/2019.2.PEDS18711DOI Listing

Intracranial volume versus static and pulsatile intracranial pressure values in children with craniosynostosis.

J Neurosurg Pediatr 2019 Apr 19:1-9. Epub 2019 Apr 19.

1Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Oslo, Norway; and.

OBJECTIVEReduced intracranial volume (ICV) and raised intracranial pressure (ICP) are assumed to be principal pathophysiological mechanisms in childhood craniosynostosis. This study examined the association between ICV and ICP and whether ICV can be used to estimate the ICP.METHODSThe authors analyzed ICV and ICP measurements from children with craniosynostosis without concurrent hydrocephalus and from age-matched individuals without craniosynostosis who underwent diagnostic ICP measurement. Read More

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http://dx.doi.org/10.3171/2019.2.PEDS18767DOI Listing
April 2019
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Clinical outcome of V-Y flap with latissimus dorsi and gluteal advancement for treatment of large thoracolumbar myelomeningocele defects: a comparative study.

J Neurosurg Pediatr 2019 Apr 19:1-10. Epub 2019 Apr 19.

1Department of Neurosurgery.

OBJECTIVESurgical repair and closure of myelomeningocele (MMC) defects are important and vital, as the mortality rate is as high as 65%-70% in untreated patients. Closure of large MMC defects is challenging for pediatric neurosurgeons and plastic surgeons. The aim of the current study is to report the operative characteristics and outcome of a series of Iranian patients with large MMC defects utilizing the V-Y flap and with latissimus dorsi or gluteal muscle advancement. Read More

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http://dx.doi.org/10.3171/2019.1.PEDS18232DOI Listing

Predictors of endoscopic third ventriculostomy ostomy status in patients who experience failure of endoscopic third ventriculostomy with choroid plexus cauterization.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

1Surgical Outcomes Center for Kids, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville.

OBJECTIVEAt failure of endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC), the ETV ostomy may be found to be closed or open. Failure with a closed ostomy may indicate a population that could benefit from evolving techniques to keep the ostomy open and may be candidates for repeat ETV, whereas failure with an open ostomy may be due to persistently abnormal CSF dynamics. This study seeks to identify clinical and radiographic predictors of ostomy status at the time of ETV/CPC failure. Read More

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April 2019
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Lumbar laminotomy for the intrathecal administration of nusinersen for spinal muscular atrophy: technical note and outcomes.

J Neurosurg Spine 2019 Apr 19:1-5. Epub 2019 Apr 19.

3Neurological Surgery, Oregon Health & Science University, Portland, Oregon.

Nusinersen (Spinraza) is a US Food and Drug Administration-approved intrathecal medication for the treatment of spinal muscular atrophy (SMA). Adult patients with SMA often undergo thoracolumbar fusion to treat neurogenic scoliosis, preventing thecal access. The authors report a laminotomy technique and the ease of intrathecal access in three SMA patients with prior thoracolumbar fusions. Read More

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http://dx.doi.org/10.3171/2019.2.SPINE181366DOI Listing

Adjacent-segment disease following two-level axial lumbar interbody fusion.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

3Department of Orthopaedic Surgery, University of Tennessee College of Medicine, Chattanooga, Tennessee.

OBJECTIVEWhile long-term studies have evaluated adjacent-segment disease (ASD) following posterior lumbar spine arthrodesis, no such studies have assessed the incidence and prevalence of ASD following axial lumbar interbody fusion (AxiaLIF). The aim of this study was to estimate the incidence of ASD following AxiaLIF.METHODSThe authors retrospectively reviewed the medical records of 149 patients who underwent two-level index AxiaLIF and had at least 2 years of radiographic and clinical follow-up. Read More

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http://dx.doi.org/10.3171/2019.2.SPINE18929DOI Listing
April 2019
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Arachnoid web of the spine: a systematic literature review.

J Neurosurg Spine 2019 Apr 19:1-10. Epub 2019 Apr 19.

2Department of Neurosurgery, Weill Cornell Brain and Spine Center, New York, New York.

OBJECTIVEAn arachnoid web of the spine (AWS) is a rare and oftentimes challenging lesion to diagnose, given its subtle radiographic findings. However, when left untreated, this lesion can have devastating effects on a patient's neurological function. To date, only limited case reports and series have been published on this topic. Read More

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http://dx.doi.org/10.3171/2019.1.SPINE181371DOI Listing

Understanding quality of life and treatment history of patients with Bertolotti syndrome compared with lumbosacral radiculopathy.

J Neurosurg Spine 2019 Apr 19:1-7. Epub 2019 Apr 19.

4Center for Spine Health, Department of Neurosurgery, Neurologic Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

OBJECTIVEBertolotti syndrome is a rare spinal condition that causes low-back pain due to a lumbosacral transitional vertebra (LSTV), which is a pseudoarticulation between the fifth lumbar transverse process and the sacral ala. Bertolotti syndrome patients are rarely studied, particularly with regard to their quality of life. This study aimed to examine the quality of life and prior treatments in patients with Bertolotti syndrome at first presentation to the authors' center in comparison with those with lumbosacral radiculopathy. Read More

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http://dx.doi.org/10.3171/2019.2.SPINE1953DOI Listing

Validation of a freehand technique for cortical bone trajectory screws in the lumbar spine.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

1Division of Orthopaedic Surgery, University of Toronto, Toronto.

OBJECTIVEThe cortical bone trajectory (CBT) technique for pedicle screw placement has gained popularity among spinal surgeons. It has been shown biomechanically to provide better fixation and improved pullout strength compared to a traditional pedicle screw trajectory. The CBT technique also allows for a less invasive approach for fusion and may have lower incidence of adjacent-level disease. Read More

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http://dx.doi.org/10.3171/2019.1.SPINE181402DOI Listing

Natural history of neuromodulation devices and therapies: a patient-centered survival analysis.

J Neurosurg 2019 Apr 19:1-7. Epub 2019 Apr 19.

OBJECTIVEDespite rapid development and expansion of neuromodulation technologies, knowledge about device and/or therapy durability remains limited. The aim of this study was to evaluate the long-term rate of hardware and therapeutic failure of implanted devices for several neuromodulation therapies.METHODSThe authors performed a retrospective analysis of patients' device and therapy survival data (Kaplan-Meier survival analysis) for deep brain stimulation (DBS), vagus nerve stimulation (VNS), and spinal cord stimulation (SCS) at a single institution (years 1994-2015). Read More

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http://dx.doi.org/10.3171/2019.2.JNS182450DOI Listing
April 2019
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Comprehensive anatomy of the foramen ovale critical to percutaneous stereotactic radiofrequency rhizotomy: cadaveric study of dry skulls.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

1Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota.

OBJECTIVEPercutaneous stereotactic radiofrequency rhizotomy (PSR) is often used to treat trigeminal neuralgia, a serious condition that results in lancinating, episodic facial pain. Thorough understanding of the microsurgical anatomy of the foramen ovale (FO) and its surrounding structures is required for efficient, effective, and safe use of this technique. This morphometric study compares anatomical and surgical orientations to identify the variations of the FO and assess cannulation difficulty. Read More

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http://dx.doi.org/10.3171/2019.1.JNS18899DOI Listing

Full tractography for detecting the position of cranial nerves in preoperative planning for skull base surgery: technical note.

J Neurosurg 2019 Apr 19:1-11. Epub 2019 Apr 19.

4Department of Neurosurgery, Stanford University Medical Center, Stanford, California.

OBJECTIVEDiffusion imaging tractography has allowed the in vivo description of brain white matter. One of its applications is preoperative planning for brain tumor resection. Due to a limited spatial and angular resolution, it is difficult for fiber tracking to delineate fiber crossing areas and small-scale structures, in particular brainstem tracts and cranial nerves. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182638DOI Listing

Intraoperative monitoring of olfactory function: a feasibility study.

J Neurosurg 2019 Apr 19:1-6. Epub 2019 Apr 19.

2Faculty of Medicine, University of Geneva, Switzerland.

OBJECTIVEIntraoperative neuromonitoring of the chemical senses (smell and taste) has never been performed. The objective of this study was to determine if olfactory-evoked potentials could be obtained intraoperatively under general anesthesia.METHODSA standard olfactometer was used in the surgical theater with hydrogen sulfide (4 ppm, 200 msec). Read More

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http://dx.doi.org/10.3171/2019.1.JNS182731DOI Listing
April 2019
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The post-aSAH syndrome: a self-reported cluster of symptoms in patients with aneurysmal subarachnoid hemorrhage.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

2Neurosurgery, Oslo University Hospital; and.

OBJECTIVEAlthough many patients recover to a good functional outcome after aneurysmal subarachnoid hemorrhage (aSAH), residual symptoms are very common and may have a large impact on the patient's daily life. The particular cluster of residual symptoms after aSAH has not previously been described in detail and there is no validated questionnaire that covers the typical problems reported after aSAH. Many of the symptoms are similar to post-concussion syndrome, which often is evaluated with the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Read More

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http://dx.doi.org/10.3171/2019.1.JNS183168DOI Listing

Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

4Department of Neurosurgery, The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, People's Republic of China.

OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity in glioma cells.METHODSThe authors used glioma tissue samples from glioma patients, cells from glioblastoma (GBM) cell lines and normal human astrocyte cells, and subcutaneous tumor-bearing U87 cells in mice to examine the effects of signaling regulation by miR-448 in the response of glioma tissues and cells to radiation treatment. Read More

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http://dx.doi.org/10.3171/2018.12.JNS181798DOI Listing
April 2019
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Neurological and neuropsychological outcome after resection of craniopharyngiomas.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

OBJECTIVECraniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality of life have been neglected for many decades. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.10.JNS181557DOI Listing
April 2019
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Sick of retirement?

J Health Econ 2019 Apr 1;65:133-152. Epub 2019 Apr 1.

Department of Economics, University of Copenhagen and Center for Economic Behavior and Inequality (CEBI), Denmark. Electronic address:

This paper examines the causal effect of retirement on health and healthcare utilization using two identification strategies on Danish full population data. First, I use a reform of the statutory retirement age in an IV design. Second, I use a large discontinuity in retirement take-up at the earliest age of retirement (60) in a regression discontinuity design. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2019.03.008DOI Listing

Comparison of glenohumeral and humerothoracical range of motion in healthy controls, osteoarthritic patients and patients after total shoulder arthroplasty performing different activities of daily living.

Gait Posture 2019 Apr 6;71:20-25. Epub 2019 Apr 6.

Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118, Heidelberg, Germany. Electronic address:

Purpose: The purpose of this study was to examine how total shoulder arthroplasty improves performance of activities of daily living compared to patients with glenohumeral osteoarthritis and how they perform compared to healthy controls.

Methods: Glenohumeral and humerothoracical elevation used by patients with primary osteoarthritis (12 participants, 16 shoulders), after total shoulder arthroplasty (16 participants, 24 shoulders) and healthy controls (11 participants, 22 shoulders) for four different activities of daily living were assessed using 3D motion analysis. Analysis of range of motion and angle time series was performed. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.001DOI Listing

A narrative synthesis of possible causes and risk factors of hoarding behaviours.

Asian J Psychiatr 2019 Apr 8;42:104-114. Epub 2019 Apr 8.

Research Division, Institute of Mental Health, Buangkok Green Medical Park, 10 Buangkok View, 539747, Singapore. Electronic address:

Background: Hoarding is a disorder characterized by excessive acquisition and persistent difficulty in discarding possessions. The behaviour has adverse emotional, physical, social, financial, and legal outcomes for the person with the disorder and family members, and might pose a significant public health problem. Hoarding has been included as a distinct disorder in the Diagnostic and Statistical Manual of Mental Disorders Fifth edition (DSM-5). Read More

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http://dx.doi.org/10.1016/j.ajp.2019.04.001DOI Listing

Catalytic co-pyrolysis of red cedar with methane to produce upgraded bio-oil.

Bioresour Technol 2019 Apr 9;285:121299. Epub 2019 Apr 9.

Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States.

Fast pyrolysis is a promising route to transform biomass into bio-oil for further refining into transportation fuels and chemicals. However, bio-oil applications suffer from several challenges due to its adverse properties. This study reports improving bio-oil properties through co-pyrolysis of biomass with methane over molybdenum/zinc (MoZn/ZHSM-5) and HZSM-5 catalysts that promote deoxygenation, decarbonylation, hydrogen transfer and aromatization reactions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608524193051
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http://dx.doi.org/10.1016/j.biortech.2019.03.138DOI Listing
April 2019
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Biological removal of HS gas in a semi-pilot scale biotrickling filter: Optimization of various parameters for efficient removal at high loading rates and low pH conditions.

Bioresour Technol 2019 Apr 8;285:121328. Epub 2019 Apr 8.

Department of Environmental Science and Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104, Republic of Korea. Electronic address:

In this study, a semi-pilot scale biotrickling filter (BTF) was operated in a continuous co-current mode to remove high concentration of hydrogen sulfide (HS) at optimum operational conditions. The early startup period of 6 days was needed, and then stable removal of HS gas at inlet concentrations up to about 2000 ppm was successfully obtained at gas retention time (GRT) of 15 min and liquid recirculation rate (LRR) of 120 ml/min. The elimination capacities (ECs) increased linearly with increase in HS loading rates (HLRs up to 38. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608524193054
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http://dx.doi.org/10.1016/j.biortech.2019.121328DOI Listing
April 2019
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Sequential utilization of bamboo biomass through reductive catalytic fractionation of lignin.

Bioresour Technol 2019 Apr 11;285:121335. Epub 2019 Apr 11.

Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China. Electronic address:

Reductive catalytic fractionation (RCF) has emerged as a new biorefinery paradigm for the fractionation and sequential utilization of entire components of biomass. Herein, we investigated the RCF of bamboo, a highly abundant herbaceous feedstock, in the presence of Pd/C catalyst. The lignin fraction in bamboo was preferentially depolymerized into well-defined low-molecular-weight phenols, with leaving carbohydrates pulp as a solid residue. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.121335DOI Listing

Effect of hydrothermal carbonization as pretreatment on energy recovery from food and paper wastes.

Bioresour Technol 2019 Apr 9;285:121329. Epub 2019 Apr 9.

Centre for Environmental Science and Engineering, IIT Bombay, Mumbai 400076, India. Electronic address:

In this study, food waste (FW) and paper wastes were subjected to hydrothermal carbonization (HTC) with a purpose to improve energy recovery potential. FW is suggested as the suitable feedstock for production of hydrochar (HC) having highest calorific value (29.6 MJ/kg). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608524193054
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http://dx.doi.org/10.1016/j.biortech.2019.121329DOI Listing
April 2019
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The functional importance of structure in unstructured protein regions.

Authors:
Norman E Davey

Curr Opin Struct Biol 2019 Apr 16;56:155-163. Epub 2019 Apr 16.

Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland; Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK. Electronic address:

After two decades of research, intrinsically disordered regions (IDRs) are established as a widespread phenomenon. The growing understanding of the significant functional role of IDRs has challenged the structure-function paradigm, proving irrefutably that a stably folded structure is not a strict requirement for function. Nonetheless, (un)structure-function relationships remain at the core of IDR-mediated interactions. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.03.009DOI Listing

Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease.

Adv Med Sci 2019 Apr 16;64(2):324-330. Epub 2019 Apr 16.

Department of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine (UCMMiT), Medical University of Gdansk, Gdynia, Poland; Department of Tropical Medicine and Epidemiology, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Gdynia, Poland.

Purpose: Hepatic alveolar echinococcosis (AE) is a parasitic disease caused by the larval stage of the tapeworm Echinococcus multilocularis. Ultrasonography is the method of choice in the initial diagnosis of AE. The aim of the study is to present the most frequent sonomorphological patterns of lesions in hepatic AE based on the analysis of ultrasound findings in patients treated for AE at the University Centre of Maritime and Tropical Medicine (UCMMiT; Gdynia, Poland), and to establish whether there is a relationship between the clinical stage of AE and the occurrence of a specific sonomorphological pattern of hepatic lesions. Read More

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http://dx.doi.org/10.1016/j.advms.2019.04.002DOI Listing

Worsening of disability caused by relapses in multiple sclerosis: A different approach.

Mult Scler Relat Disord 2019 Apr 15;32:1-8. Epub 2019 Apr 15.

The Danish Multiple Sclerosis Registry, Department of Neurology, Rigshospitalet, Copenhagen, Denmark; Department of Neurology, Danish Multiple Sclerosis Center Rigshospitalet, University of Copenhagen, Denmark.

Background: In multiple sclerosis (MS) the quantitative role of relapses in Expanded Disability Status Scale (EDSS) worsening beyond the recovery phase is not well known. Most studies have examined the predictive role of early relapses in more distant endpoints. Relapses and worsening may be associated because they could be independent effects of the same underlying disease characteristics without causal relationship. Read More

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http://dx.doi.org/10.1016/j.msard.2019.04.017DOI Listing

Slow and steady wins the race: physical limits on the rate of viral DNA packaging.

Authors:
Paul J Jardine

Curr Opin Virol 2019 Apr 16;36:32-37. Epub 2019 Apr 16.

Department of Diagnostic and Biological Sciences, University of Minnesota, 18-242 Moos Tower, 515 Delaware St SE, Minneapolis, MN 55455, United States. Electronic address:

During the assembly of dsDNA viruses such as the tailed bacteriophages and herpesviruses, the viral chromosome is compacted to near crystalline density inside a preformed head shell. DNA translocation is driven by powerful ring ATPase motors that couple ATP binding, hydrolysis, and release to force generation and movement. Studies of the motor of the bacteriophage phi29 have revealed a complex mechanochemistry behind this process that slows as the head fills. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18796257183015
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http://dx.doi.org/10.1016/j.coviro.2019.03.002DOI Listing
April 2019
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