1,636 results match your criteria Journal of cutaneous medicine and surgery[Journal]


Dermatologic Training and Practice in Canada: A Historical Overview.

J Cutan Med Surg 2019 Apr 18:1203475419840630. Epub 2019 Apr 18.

6 Royal College of Physicians and Surgeons of Canada, Ottawa, ON, Canada.

The specialty of dermatology is constantly changing to meet the medical needs of our society. The discipline is in flux because of a variety of factors such as growing population needs, technological advancements, fiscal restraint, and demographic changes. As part of an in-depth review of the specialty, the Dermatology Working Group (DWG) for the Royal College of Physicians and Surgeons of Canada sought to determine whether the current training configuration is suitably preparing graduates to meet the societal health needs of dermatology patients. Read More

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Off-Label High-Dose Secukinumab for the Treatment of Moderate-to-Severe Psoriasis.

J Cutan Med Surg 2019 Apr 16:1203475419843118. Epub 2019 Apr 16.

7 Division of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Secukinumab is an anti-IL-17A monoclonal antibody approved for the treatment of moderate-to-severe psoriasis in adult patients. Despite its favourable safety and efficacy profile in clinical trials, some patients in clinical practice fail to respond adequately to the approved maintenance regimen of 300 mg subcutaneous monthly. Some clinicians manage these patients by using off-label high-dose secukinumab regimens, which include shortening the dosing interval to 300 mg every 2 or 3 weeks instead of monthly, or increasing the monthly dose to 450 mg. Read More

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http://dx.doi.org/10.1177/1203475419843118DOI Listing
April 2019
7 Reads

Clinical Insights About Topical Treatment of Mild-to-Moderate Pediatric and Adult Atopic Dermatitis.

J Cutan Med Surg 2019 Apr 9:1203475419843108. Epub 2019 Apr 9.

9 Division of Dermatology, BC Children's Hospital; University of British Columbia, Vancouver, Canada.

Atopic dermatitis (AD) is a chronic inflammatory skin condition, also referred to as atopic eczema, that is identified by itching and recurrent eczematous lesions. It often starts in infancy where it affects up to 20% of children but is also highly prevalent in adults. AD inflicts a significant psychosocial burden on patients and their families and increases the risk of other immune-mediated inflammatory conditions, such as asthma and allergic rhinitis, food allergy, and mental health disorders. Read More

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http://dx.doi.org/10.1177/1203475419843108DOI Listing
April 2019
2 Reads

Existing and Emerging Therapies for Cutaneous T-Cell Lymphoma.

J Cutan Med Surg 2019 Apr 3:1203475419840629. Epub 2019 Apr 3.

1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas characterized by an infiltration of malignant monoclonal T lymphocytes into the skin. Mycosis fungoides (MF), the most common subtype, and the rarer Sézary syndrome (SS), are considered the classical forms of CTCL, which, because of a varying presentation and lack of genetic and immunophenotypical markers, can often have a delayed diagnosis. With skin-directed topical treatment being the mainstay of therapy in the early stages, there is an absence of long-term curative therapies for advanced disease. Read More

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April 2019
8 Reads

The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review.

J Cutan Med Surg 2019 Apr 2:1203475419836435. Epub 2019 Apr 2.

3 SKiN Centre for Dermatology, Peterborough, ON, Canada.

Acrodermatitis continua of Hallopeau is a rare subtype of pustular psoriasis that presents as a sterile, pustular eruption commonly in the finger tips and toes. This disease inflicts both the skin and nail bed, and causes severe disfigurement of the distal phalanges. Because it is a variant of pustular psoriasis, acrodermatitis continua of Hallopeau is commonly managed with antipsoriatic medications. Read More

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http://dx.doi.org/10.1177/1203475419836435DOI Listing
April 2019
1 Read

The Cutaneous Microbiome: Implications for Dermatology Practice.

J Cutan Med Surg 2019 Apr 2:1203475419839939. Epub 2019 Apr 2.

4 Provincial Laboratory for Public Health (ProvLab), Alberta Public Laboratories, Edmonton, AB, Canada.

The human integument is inhabited by a vast array of microorganisms known collectively as the cutaneous microbiome. As a result of advances in laboratory science, our understanding of the diversity and complexity of the human microbiome is rapidly evolving. In particular, advances in the field of genomics have enabled the study of the cutaneous microbiome with a hitherto unimaginable level of detail, resulting in a maturation of our understanding of cutaneous health and disease. Read More

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http://dx.doi.org/10.1177/1203475419839939DOI Listing
April 2019
3 Reads

Nail Changes in Sézary Syndrome: A Single-Center Study and Review of the Literature.

J Cutan Med Surg 2019 Mar 27:1203475419839937. Epub 2019 Mar 27.

1 Cutaneous Lymphoma Program, Department of Dermatology, University of Pittsburgh Medical Center, PA, USA.

Background:: The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications.

Objectives:: The objectives of this study were to identify and describe the most frequent nail alterations in patients with SzS. Read More

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March 2019
3 Reads

The Use of Janus Kinase Inhibitors in Vitiligo: A Review of the Literature.

J Cutan Med Surg 2019 Mar 22:1203475419833609. Epub 2019 Mar 22.

1 Queen's University, Kingston, ON, Canada.

Vitiligo is a common acquired depigmenting disorder characterized by the development of white macules and patches due to the loss of melanocytes. Patients with vitiligo can be stigmatized by society, making the disease a source of psychological stress that can considerably affect quality of life. The goal of vitiligo treatment is to obtain skin repigmentation in the majority of cases, and less commonly to depigment the remaining normal skin. Read More

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March 2019
4 Reads

Validation of a Hidradenitis Suppurativa Self-Assessment Tool.

J Cutan Med Surg 2019 Mar 22:1203475419839965. Epub 2019 Mar 22.

1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Background:: Hidradenitis suppurativa (HS) is a debilitating dermatologic condition presenting with recurrent abscesses. While there are multiple scales to determine HS severity, none are designed for self-administration. A validated severity self-assessment tool may facilitate survey research and improve communication by allowing patients to objectively report their HS severity between clinic visits. Read More

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http://dx.doi.org/10.1177/1203475419839965DOI Listing
March 2019
3 Reads

Checklist for the Systemic Treatment of Psoriasis Using Biologics: A Delphi Study.

J Cutan Med Surg 2019 Mar 10:1203475419833605. Epub 2019 Mar 10.

2 Department of Medicine, University of Ottawa, Canada.

Background:: Despite the complexity of psoriasis treatment using biologic therapy, there does not exist a standardized synoptic reporting form for the initiation of this population. The purpose of this study was to use a modified Delphi approach to develop a standard checklist for the standardized documentation of patients receiving systemic biologic therapy for psoriasis.

Methods:: A modified Delphi survey was conducted over 3 rounds (February 2017 through January 2018). Read More

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March 2019
21 Reads

Cutaneous Metastasis of a Papillary Thyroid Carcinoma.

J Cutan Med Surg 2019 Mar/Apr;23(2):224

3 Department of Pathology, Hotel-Dieu de Quebec et CRCEO, Quebec City, QC, Canada.

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http://dx.doi.org/10.1177/1203475418800936DOI Listing
March 2019
1 Read

Timing of Clinical Detection and Biopsy in Invasive Melanoma and Breslow Depth: A Chart Review.

J Cutan Med Surg 2019 Mar/Apr;23(2):229-230

2 Division of Dermatology, Department of Medicine, The Ottawa Hospital, Ottawa ON, Canada.

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http://dx.doi.org/10.1177/1203475418800946DOI Listing
March 2019
5 Reads

The Father of Medicine on Dermatology.

J Cutan Med Surg 2019 Mar/Apr;23(2):237

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http://dx.doi.org/10.1177/1203475418811358DOI Listing
March 2019
1 Read

Twenty Years Without Treatment: A Presentation of Arthritis Mutilans With Psoriasis.

J Cutan Med Surg 2019 Mar/Apr;23(2):223

2 Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1203475418792002DOI Listing
March 2019
1 Read

Mohs Micrographic Surgery: Development of the Technique.

J Cutan Med Surg 2019 Mar/Apr;23(2):236

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http://dx.doi.org/10.1177/1203475418811346DOI Listing
March 2019
1 Read

Evolution of Partially Involuting Congenital Hemangiomas of the Face.

J Cutan Med Surg 2019 Mar/Apr;23(2):225

1 University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia.

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http://journals.sagepub.com/doi/10.1177/1203475418803061
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March 2019
7 Reads
0.714 Impact Factor

Eliminating Errors During Routine Biopsies Using a Dual Independent Verification Protocol.

J Cutan Med Surg 2019 Mar/Apr;23(2):234-235

2 Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.1177/1203475418811339DOI Listing

2018: Editor's Report- A Year of Engagement.

Authors:
Kirk Barber

J Cutan Med Surg 2019 Mar/Apr;23(2):145-147

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http://dx.doi.org/10.1177/1203475419831304DOI Listing

Canadian Research Contributions per Medical Specialty in 2 High-Impact Journals.

J Cutan Med Surg 2019 Mar/Apr;23(2):231-233

1 SKiN Centre for Dermatology, Peterborough, ON, Canada.

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http://dx.doi.org/10.1177/1203475418803075DOI Listing

Early Disseminated Lyme Disease in a 15-Year-Old Male.

J Cutan Med Surg 2019 Mar/Apr;23(2):222

2 Department of Medicine, Division of Clinical Dermatology & Cutaneous Science, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1177/1203475418791995DOI Listing
March 2019
1 Read

Time-Saving Comparison of Wound Measurement Between the Ruler Method and the Swift Skin and Wound App.

J Cutan Med Surg 2019 Mar/Apr;23(2):226-228

4 Department of Medicine, Division of Dermatology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1203475418800942DOI Listing

Satisfaction and Awareness of Systemic Psoriasis Treatments: A National Survey Comparing Biologic and Nonbiologic Users.

J Cutan Med Surg 2019 Mar/Apr;23(2):148-156. Epub 2019 Feb 25.

4 Department of Biochemistry, University of Toronto, ON, Canada.

Background:: There is ongoing development of new therapies for psoriasis, including biologic and systemic agents such as interleukin-17, interleukin-23, and phosphodiesterase-4 inhibitors. The development of these agents has changed the landscape of psoriasis treatment options.

Objective:: The objective of this study was to characterize the impact of newer biologic and systemic agents approved by June 2016 on patient outcomes. Read More

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http://journals.sagepub.com/doi/10.1177/1203475418808764
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http://dx.doi.org/10.1177/1203475418808764DOI Listing
February 2019
4 Reads
0.714 Impact Factor

Unilateral Laterothoracic Exanthema: An Underrecognized, Innocuous Entity.

J Cutan Med Surg 2019 Jan/Feb;23(1):97

1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1177/1203475418782149DOI Listing
February 2019
0.714 Impact Factor

Cutaneous Chromoblastomycosis: A Prototypal Case.

J Cutan Med Surg 2019 Jan/Feb;23(1):98

2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1177/1203475418789029DOI Listing
February 2019
1 Read
0.714 Impact Factor

Antibiotics for Prevention of Postoperative Infection From Mohs on the Leg: A Survey of the American College of Mohs Surgery.

J Cutan Med Surg 2019 Jan/Feb;23(1):121-122

1 Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1177/1203475418800944DOI Listing
February 2019
1 Read

Practical Guidelines for Managing Patients With Psoriasis on Biologics: An Update.

J Cutan Med Surg 2019 Jan/Feb;23(1_suppl):3S-12S

1 Cumming School of Medicine, Division of Dermatology, University of Calgary, Calgary, AB, Canada.

The paradigm for treating inflammatory diseases has shifted dramatically in the past 10 to 20 years with the discovery of targeted therapeutics or "biologic" agents. Patients with rheumatoid arthritis, inflammatory bowel disease, psoriatic arthritis, and psoriasis, among others, are reaping the benefits of decades of bench to bedside research, allowing them to live more productive lives with less side effects than traditional systemic therapies. Despite these advances, many physicians unfamiliar with biologics are left to care for the basic needs of these patients and may be unaware of the multisystem comorbidities associated with psoriasis and the screening, monitoring, and other special considerations required of biologics patients. Read More

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http://dx.doi.org/10.1177/1203475418811347DOI Listing
February 2019

Treating to Target(s) With Interleukin-17 Inhibitors.

J Cutan Med Surg 2019 Mar/Apr;23(2_suppl):3S-34S. Epub 2019 Feb 11.

12 University of Alberta, Edmonton, AB, Canada.

Background:: The treat-to-target (T2T) strategy has become established in several medical specialties as a key guidance to optimal therapeutic decision making. T2T may be effective in the assessment of the biologic class of agents called interleukin (IL)-17 inhibitors, which are emerging as a safe and effective treatment option for autoimmune inflammatory conditions such as plaque psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS).

Objective:: The objective of this article is to use a T2T approach for the evaluation of the effectiveness and safety of IL-17 inhibitors in the management of patients with plaque psoriasis, PsA, and AS. Read More

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http://dx.doi.org/10.1177/1203475418824565DOI Listing
February 2019
12 Reads

A Qualitative Analysis of Canadian Indoor Tanning Policies.

J Cutan Med Surg 2019 Jan 28:1203475418825114. Epub 2019 Jan 28.

2 Photomedicine Institute, Vancouver Coastal Health and Department of Dermatology and Skin Science, University of British Columbia, Canada.

Background:: The International Agency for Research on Cancer classifies artificial tanning devices as Group 1 human carcinogens. Studies have shown that use of indoor tanning before age 35 can increase the risk of melanoma development by 75%. It has therefore been recommended that indoor tanning use be restricted in individuals younger than age 18. Read More

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http://dx.doi.org/10.1177/1203475418825114DOI Listing
January 2019
5 Reads

The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature.

J Cutan Med Surg 2019 Jan 28:1203475418824079. Epub 2019 Jan 28.

1 SKiN Centre for Dermatology, Peterborough, ON, Canada.

Alopecia areata (AA) is a chronic, immune-mediated disorder that targets hair follicle epithelium, thereby restricting hair growth in localized patches. Although several therapies for AA have been tested, responses with traditional therapies have been limited. In recent years, numerous reports have been published of patients with AA responding to Janus kinase (JAK) inhibitors. Read More

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http://dx.doi.org/10.1177/1203475418824079DOI Listing
January 2019
1 Read

Combination Therapies for Hidradenitis Suppurativa: A Retrospective Chart Review of 31 Patients.

J Cutan Med Surg 2019 Jan 18:1203475418823529. Epub 2019 Jan 18.

2 Division of Dermatology, Faculty of Medicine, University of Ottawa and The Ottawa Hospital, ON, Canada.

Background:: Although a variety of medical and surgical interventions exist for the treatment of hidradenitis suppurativa (HS), it remains a challenging disease to manage because of its variable presentation and unpredictable clinical course. Apart from the combination of clindamycin and rifampin, the success of other combination therapies is largely unknown.

Objectives:: The goal of our study was to examine the clinical utility of various combination therapies for the treatment of HS. Read More

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http://dx.doi.org/10.1177/1203475418823529DOI Listing
January 2019
7 Reads

Ointment Pseudo-Cheilitis: A Disease Distinct from Factitial Cheilitis. A Series of 13 Patients from São Paulo, Brazil.

J Cutan Med Surg 2019 Jan 17:1203475418825112. Epub 2019 Jan 17.

3 Department of Pathology, Dental School, University of São Paulo, Brazil.

Background:: The terms exfoliative cheilitis, factitial cheilitis, and morsicatio labiorum are used to describe self-inflicted lesions of the lip.

Objective:: Here we report and analyze clinical, pathological, and therapeutic data on 13 patients with a form of factitial cheilitis that we believe should be considered a separate entity.

Results:: Eight patients were male and 5 patients were female. Read More

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http://dx.doi.org/10.1177/1203475418825112DOI Listing
January 2019
16 Reads

The Efficacy of Platelet-Rich Plasma in the Field of Hair Restoration and Facial Aesthetics-A Systematic Review and Meta-analysis.

J Cutan Med Surg 2019 Mar/Apr;23(2):185-203. Epub 2019 Jan 4.

2 Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Canada.

As a promising alternative to traditional treatment, platelet-rich plasma (PRP) is being used to encourage hair growth through the release of growth factors and cytokines. In addition to hair restoration, PRP's multifactorial capabilities can also be used to treat aging skin, facial scarring, and acne. The purpose of this review is to critically examine the success of PRP in the field of dermatology, with specific attention to the role of PRP in hair restoration. Read More

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http://journals.sagepub.com/doi/10.1177/1203475418818073
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http://dx.doi.org/10.1177/1203475418818073DOI Listing
January 2019
3 Reads

Margin-Controlled, Staged Surgical Excision in the Treatment of High-Risk Basal Cell Carcinomas of the Head and Neck Region.

J Cutan Med Surg 2018 Dec 17:1203475418820868. Epub 2018 Dec 17.

2 Department of Plastic Reconstructive and Aesthetic Surgery, Marmara University School of Medicine, Istanbul, Turkey.

Background:: The most common skin cancer is basal cell carcinoma (BCC), and the gold-standard treatment for high-risk tumours is Mohs surgery. However, alternative methods are needed for high-risk tumours in countries where the performance rate of Mohs surgery is low.

Objectives:: The objective of this article is to investigate the feasibility, efficacy, and safety of margin-controlled, staged surgical excision (MCSSE) in high-risk tumours as a possible treatment alternative. Read More

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http://dx.doi.org/10.1177/1203475418820868DOI Listing
December 2018
17 Reads

Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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http://dx.doi.org/10.1177/1203475418819992DOI Listing
December 2018
7 Reads

Psoriasis and Atopic Dermatitis "Resistant" to Topical Treatment Responds Rapidly to Topical Desoximetasone Spray.

J Cutan Med Surg 2019 Mar/Apr;23(2):157-163. Epub 2018 Dec 17.

1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose:: Topical corticosteroids (TS) are a treatment for atopic dermatitis (AD) and psoriasis (Ps). We assessed whether use of a TS under conditions designed to enhance adherence would be effective in patients who "failed" TS in the outpatient setting.

Methods:: Individuals with treatment-resistant Ps or AD were recruited (AD, n = 12; Ps, n = 12). Read More

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http://dx.doi.org/10.1177/1203475418818082DOI Listing
December 2018
2 Reads

Vaccination Guidelines for Patients With Immune-Mediated Disorders on Immunosuppressive Therapies.

J Cutan Med Surg 2019 Jan/Feb;23(1):50-74. Epub 2018 Nov 21.

9 Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Background:: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient population remain suboptimal.

Objectives:: To evaluate the safety and efficacy of vaccines in individuals exposed to immunosuppressive therapies and provide evidence-based clinical practice recommendations.

Methods:: A literature search for vaccination safety and efficacy in patients on immunosuppressive therapies (2009-2017) was conducted. Read More

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http://dx.doi.org/10.1177/1203475418811335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330697PMC
November 2018
18 Reads

Comparison of Management Guidelines for Moderate-to-Severe Plaque Psoriasis: A Review of Phototherapy, Systemic Therapies, and Biologic Agents.

J Cutan Med Surg 2019 Mar/Apr;23(2):204-221. Epub 2018 Nov 21.

2 Division of Dermatology, University of Toronto, ON, Canada.

Introduction:: Many international guidelines for management of psoriasis exist and most have variations in grading evidence quality, strength of recommendations, and dosing. The objective of our review is to compare international guidelines published in the United Kingdom, Canada, Europe, and the United States for the management of moderate-to-severe plaque psoriasis.

Methods:: We conducted a literature review on systemic therapies and phototherapy for moderate-to-severe plaque psoriasis in adult patients. Read More

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http://dx.doi.org/10.1177/1203475418814234DOI Listing
November 2018
21 Reads
0.714 Impact Factor

Ixekizumab (Interleukin 17A Antagonist): 12-week Efficacy and Safety Outcomes in Real-world Clinical Practice.

J Cutan Med Surg 2019 Mar/Apr;23(2):174-177. Epub 2018 Nov 18.

3 Faculty of Medicine, University of Toronto, ON, Canada.

Background:: Current knowledge of the efficacy and safety of ixekizumab is limited to data from phase III randomized controlled trials (RCTs). A gap exists in our understanding of treatment outcomes of this newly available biologic in real-world clinical practice.

Objective:: This study explores the efficacy and safety of ixekizumab in non-RCT patients to compare real-world outcomes to those reported in RCTs. Read More

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http://journals.sagepub.com/doi/10.1177/1203475418814229
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http://dx.doi.org/10.1177/1203475418814229DOI Listing
November 2018
19 Reads
0.714 Impact Factor

Aesthetic Dermatologic Surgery Training in Canadian Residency Programs.

J Cutan Med Surg 2019 Mar/Apr;23(2):164-173. Epub 2018 Nov 16.

1 Division of Dermatology, Department of Medicine, University of Ottawa, ON, Canada.

Background:: The public and other physicians expect dermatologists to be experts on aesthetic dermatology services. In Canada, current challenges may limit residents from achieving competency in aesthetic dermatology during their training. This may adversely affect patient safety, create medicolegal risks, and deter graduates from offering aesthetic procedures. Read More

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http://journals.sagepub.com/doi/10.1177/1203475418814228
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http://dx.doi.org/10.1177/1203475418814228DOI Listing
November 2018
2 Reads

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section IV: Treatment Options for the Management of Atopic Dermatitis.

J Cutan Med Surg 2018 Nov/Dec;22(1_suppl):21S-29S

The objectives of therapy for atopic dermatitis (AD) are to reduce skin inflammation and pruritus, restore skin barrier function, and improve quality of life (QoL). Treatments can be classified as moisturizing and basic care, topical therapy, phototherapy, and systemic therapy. In this review, we summarize the treatments for AD and recommendations for their use. Read More

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http://dx.doi.org/10.1177/1203475418805721DOI Listing
January 2019
11 Reads

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section V: Consensus Statements on the Assessment and Management of Adult Patients With Moderate-to-Severe Atopic Dermatitis.

J Cutan Med Surg 2018 Nov/Dec;22(1_suppl):30S-35S

2 Probity Medical Research, Waterloo, ON, Canada.

This document is a concise, current, and practical guide for dermatologists and other health care providers managing adult patients with moderate-to-severe atopic dermatitis (AD). The recommendations made here are based on a consensus of specialists with extensive experience managing patients with AD. Topics reviewed in this publication include AD pathophysiology, assessment, comorbidities, and treatment options. Read More

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http://dx.doi.org/10.1177/1203475418803625DOI Listing
January 2019
21 Reads

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section I: Pathophysiology of Atopic Dermatitis and Implications for Systemic Therapy.

J Cutan Med Surg 2018 Nov/Dec;22(1_suppl):6S-9S

Atopic dermatitis (AD) is a chronic, relapsing, and remitting inflammatory skin disease whose onset typically occurs early in life. AD pathophysiology includes genetic, immune, and environmental factors contributing to chronic inflammation. A rapidly evolving understanding of the pathogenesis of AD has led to the development of several treatment options for AD in adults, including topicals, phototherapy, and systemic therapies. Read More

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http://dx.doi.org/10.1177/1203475418803626DOI Listing
January 2019
16 Reads

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document.

J Cutan Med Surg 2018 Nov/Dec;22(1_suppl):3S-5S

2 Probity Medical Research, Waterloo, ON, Canada.

Background:: Atopic dermatitis (AD) is a chronic, relapsing, and remitting inflammatory skin disease with complex pathophysiology, primarily driven by type 2 inflammation. Existing guidelines often do not reflect all current therapeutic options and guidance on the practical management of patients with AD is lacking.

Objectives:: To develop practical, up-to-date guidance on the assessment and management of adult patients with AD. Read More

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http://journals.sagepub.com/doi/10.1177/1203475418803627
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http://dx.doi.org/10.1177/1203475418803627DOI Listing
January 2019
24 Reads

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section II: Tools for Assessing the Severity of Atopic Dermatitis.

J Cutan Med Surg 2018 Nov/Dec;22(1_suppl):10S-16S

Clinicians rely on clinical measures to define the severity of atopic dermatitis and assess outcomes of therapy. These measures can be objective (ie, physician assessments of disease severity) or subjective (ie, patient-reported symptoms and quality of life outcomes). In this review, the most commonly used tools for assessing atopic dermatitis severity in adult patients are presented and compared. Read More

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http://journals.sagepub.com/doi/10.1177/1203475418803628
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http://dx.doi.org/10.1177/1203475418803628DOI Listing
January 2019
19 Reads

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section III: Evaluation of Atopic Dermatitis Patients for Comorbidities.

J Cutan Med Surg 2018 Nov/Dec;22(1_suppl):17S-20S

Atopic dermatitis (AD) is often associated with other atopic diseases, including asthma, allergic rhinitis, atopy-associated eye disorders, and eosinophilic esophagitis. Depression and anxiety are also comorbidities to AD that significantly affect quality of life and should be screened for in patients with AD. Links to other comorbidities such as cardiovascular disease and malignancy are considered inconclusive, but patient counselling and screening may be appropriate in some patients. Read More

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http://dx.doi.org/10.1177/1203475418805709DOI Listing
January 2019
17 Reads

Dermatology-Related Uses of Medical Cannabis Promoted by Dispensaries in Canada, Europe, and the United States.

J Cutan Med Surg 2019 Mar/Apr;23(2):178-184. Epub 2018 Oct 31.

1 Division of Dermatology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada.

There is a growing interest in the use of medical cannabis for a variety of dermatologic conditions. Despite the lack of evidence to validate the effectiveness and safety of marijuana, it is approved to treat a variety of dermatologic conditions in the United States. Furthermore, medical cannabis dispensaries have been making unsubstantiated claims about medical cannabis. Read More

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http://dx.doi.org/10.1177/1203475418808761DOI Listing
October 2018
4 Reads

Vitamin D Level and Supplementation in Pediatric Atopic Dermatitis: A Randomized Controlled Trial.

J Cutan Med Surg 2019 Jan/Feb;23(1):44-49. Epub 2018 Oct 18.

1 Section of Dermatology, Division of Pediatric Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Background:: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a pruritic eczematous rash. Evidence surrounding the role of serum vitamin D (VD) in modifying disease severity is inconsistent.

Objectives:: To determine whether VD levels are correlated with AD severity and the effects of VD supplementation on disease modification. Read More

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http://dx.doi.org/10.1177/1203475418805744DOI Listing
October 2018
17 Reads