27,575,838 results match your criteria Journal of comparative physiology. A Neuroethology sensory neural and behavioral physiology[Journal]

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The use of normal human immunoglobulin (NHIG) for public health purposes in Queensland 2004-2014 and Australia 2014-2016

Commun Dis Intell (2018) 2019 Mar 15;43. Epub 2019 Mar 15.

School of Medicine and Menzies Health Institute Queensland, Griffith University - Metro North Public Health Unit, Metro North Hospital and Health Service

Objective To describe the use of normal human immunoglobulin (NHIG) recommended for public health purposes in Queensland and Australia. Methods Queensland public health unit (PHU) data on notified cases of measles, rubella and hepatitis A from 2004 to 2014 were examined; particularly regarding the number of contacts offered NHIG and the volume recommended per contact. The National Blood Authority (NBA) provided unidentified data from NHIG order form inception (June 2014) through December 2016. Read More

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Australia’s notifiable disease status, 2015: Annual report of the National Notifiable Diseases Surveillance System

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Commun Dis Intell (2018) 2019 Mar 15;43. Epub 2019 Mar 15.

In 2015, 67 diseases and conditions were nationally notifiable in Australia. States and territories reported a total of 320,480 notifications of communicable diseases to the National Notifiable Diseases Surveillance System, an increase of 16% on the number of notifications in 2014. In 2015, the most frequently notified diseases were vaccine preventable diseases (147,569 notifications, 46% of total notifications), sexually transmissible infections (95,468 notifications, 30% of total notifications), and gastrointestinal diseases (45,326 notifications, 14% of total notifications). Read More

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Cancer-Associated Fibroblasts and Desmoplastic Reactions Related to Cancer Invasiveness in Patients With Colorectal Cancer.

Ann Coloproctol 2019 Feb 28;35(1):36-46. Epub 2019 Feb 28.

Department of Biochemistry, Pusan National University School of Medicine, Busan, Korea.

Purpose: We evaluated the relationship of cancer-associated fibroblasts (CAFs) and desmoplastic reactions with cancer invasiveness and long-term outcomes in patients with colorectal cancer (CRC).

Methods: Histologic evaluation of mature CAFs and desmoplasia was performed by observing the collagen fiber structure and fibroblast cytomorphology in the intratumoral stroma and invasive front of CRC tissues. Cancer-cell invasiveness was evaluated using lymphatic invasion, vascular invasion, perineural invasion, tumor budding, and tumor growth patterns. Read More

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http://dx.doi.org/10.3393/ac.2018.09.10DOI Listing
February 2019

Variation in the Height of Rectal Cancers According to the Diagnostic Modalities.

Ann Coloproctol 2019 Feb 28;35(1):24-29. Epub 2019 Feb 28.

Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Although the height of a rectal tumor above the anal verge (tumor height) partly determines the treatment strategy, no practical standard exists for reporting this. We aimed to demonstrate the differences in tumor height according to the diagnostic modality used for its measurement.

Methods: We identified 100 patients with rectal cancers located within 15 cm of the anal verge who had recorded tumor heights measured by using magnetic resonance imaging (MRI), colonoscopy, and digital rectal examination (DRE). Read More

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http://dx.doi.org/10.3393/ac.2018.07.31DOI Listing
February 2019

Does the Different Locations of Colon Cancer Affect the Oncologic Outcome? A Propensity-Score Matched Analysis.

Ann Coloproctol 2019 Feb 28;35(1):15-23. Epub 2019 Feb 28.

Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Purpose: We evaluate the prognostic value of primary tumor location for oncologic outcomes in patients with colon cancer (CC).

Methods: CC patients treated with curative surgery between 2009 and 2012 were classified into 2 groups: right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Recurrence-free survival (RFS) and overall survival (OS) were examined based on tumor stage. Read More

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http://dx.doi.org/10.3393/ac.2018.07.25DOI Listing
February 2019

Effect of Hyperoxygenation During Surgery on Surgical Site Infection in Colorectal Surgery.

Ann Coloproctol 2019 Feb 28;35(1):9-14. Epub 2019 Feb 28.

Department of General Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Purpose: Despite the use of different surgical methods, surgical site infection is still an important cause of mortality and morbidity in patients and imposes a considerable cost on the healthcare system. Administration of supplemental oxygen during surgery has been reported to reduce surgical site infection (SSI); however, that result is still controversial. This study was performed to evaluate the effect of hyperoxygenation during colorectal surgery on the incidence of wound infection. Read More

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http://coloproctol.org/journal/view.php?doi=10.3393/ac.2018.
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http://dx.doi.org/10.3393/ac.2018.01.16DOI Listing
February 2019
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How to Achieve a Higher Pathologic Complete Response in Patients With Locally Advanced Rectal Cancer Who Receive Preoperative Chemoradiation Therapy.

Authors:
Suk-Hwan Lee

Ann Coloproctol 2019 Feb 28;35(1):3-8. Epub 2019 Feb 28.

Department of Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

The current standard of care for treating patients with locally advanced rectal cancer includes preoperative chemoradiation therapy (PCRT) followed by a total mesorectal excision and postoperative adjuvant chemotherapy. A subset of these patients has achieved a pathologic complete response (pCR) and they have shown improved disease-free and overall survival compared to non-pCR patients. Thus, many efforts have been made to achieve a higher pCR through PCRT. Read More

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http://dx.doi.org/10.3393/ac.2019.02.17DOI Listing
February 2019

Anastomotic Sinus Developed From Leakage in Rectal Cancer Resection: When Can We Reverse the Defunctioning Stoma?

Authors:
Chang Hyun Kim

Ann Coloproctol 2019 Feb 28;35(1):1-2. Epub 2019 Feb 28.

Department of Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Korea.

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http://dx.doi.org/10.3393/ac.2018.12.28DOI Listing
February 2019

Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model.

Biomol Ther (Seoul) 2019 Mar 13. Epub 2019 Mar 13.

Department of Microbiology, Biochemistry and Molecular Genetics, Public Health Research Institute, New Jersey Medical School, Newark, NJ 07103, USA.

infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. In particular, we demonstrated accumulation of lipid droplets and impaired cardiac lipid metabolism in the hearts of cardiomyopathic mice and patients, and their association with impaired mitochondrial functions and endoplasmic reticulum (ER) stress in CD mice. Read More

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http://dx.doi.org/10.4062/biomolther.2018.193DOI Listing

Dopaminergic Effects of Major Bath Salt Constituents 3,4-Methylenedioxypyrovalerone (MDPV), Mephedrone, and Methylone Are Enhanced Following Co-exposure.

Neurotox Res 2019 Mar 16. Epub 2019 Mar 16.

Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Box 70594, Johnson City, TN, USA.

Designer drug mixtures popularized as "bath salts" often contain the synthetic cathinones 3,4 methylenedioxypyrovalerone (MDPV), mephedrone, and methylone in various combinations. However, most preclinical investigations have only assessed the effects of individual bath salt constituents, and little is known about whether co-exposure to MDPV, mephedrone, and methylone produces significant neuropharmacological interactions. This study evaluated and compared how MDPV, mephedrone, and methylone influence discrete brain tissue dopamine (DA) levels and motor stimulant responses in mice when administered alone and as a ternary mixture. Read More

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http://dx.doi.org/10.1007/s12640-019-00020-2DOI Listing
March 2019
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Whole-genome analysis of the colonization-resistant bacterium Phytobacter sp. SCO41 isolated from Bacillus nematocida B16-fed adult Caenorhabditis elegans.

Mol Biol Rep 2019 Mar 16. Epub 2019 Mar 16.

Department of Life Science and Biotechnology, Nanyang Normal University, Nanyang, 473000, People's Republic of China.

Colonization resistance is an important attribute for bacterial interactions with hosts, but the mechanism is still not completely clear. In this study, we found that Phytobacter sp. SCO41 can effectively inhibit the in vivo colonization of Bacillus nematocida B16 in Caenorhabditis elegans, and we revealed the colonization resistance mechanism. Read More

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http://link.springer.com/10.1007/s11033-018-04574-w
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http://dx.doi.org/10.1007/s11033-018-04574-wDOI Listing
March 2019
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In silico prediction of short hairpin RNA and in vitro silencing of activin receptor type IIB in chicken embryo fibroblasts by RNA interference.

Mol Biol Rep 2019 Mar 16. Epub 2019 Mar 16.

Division of Animal Genetics & Breeding, Indian Veterinary Research Institute, Izatnagar, U.P., India.

Gene silencing by RNA interference is extensively used reverse genetic approach to analyse the implications of any gene in mammalian systems. The silencing of the Activin type IIB receptor belonging to transforming growth factor beta superfamily has demonstrated increase in muscle growth in many species. We designed five short hairpin RNA constructs targeting coding region of chicken ACTRIIB. Read More

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http://link.springer.com/10.1007/s11033-019-04756-0
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http://dx.doi.org/10.1007/s11033-019-04756-0DOI Listing
March 2019
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Gene dosage of DAX-1, determining in sexual differentiation: duplication of DAX-1 in two sisters with gonadal dysgenesis.

Mol Biol Rep 2019 Mar 16. Epub 2019 Mar 16.

Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Cra 7 No. 40-62, Bogotá, 110231, Colombia.

Two sisters phenotypically normal females, presenting with tumor abdominal mass with histopathological findings of teratoma and gonadoblastoma associated to 46,XY male-to-female sex reversal syndrome, secondary to a duplication in DAX-1, possibly inherited of maternal gonadal mosaicism. Copy number variation and functional effects of the duplication were done by MLPA multiplex ligation-dependent probe amplification and real time PCR. DAX-1, also known as dosage sensitive sex reversal gene (DSS), is considered the most likely candidate gene involved in XY gonadal dysgenesis when overexpressed. Read More

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http://dx.doi.org/10.1007/s11033-019-04758-yDOI Listing

Are bottom-up approaches good for promoting social-ecological fit in urban landscapes?

Ambio 2019 Mar 16. Epub 2019 Mar 16.

Stockholm Resilience Centre, Stockholm University, Kräftriket 2B, 10691, Stockholm, Sweden.

Bottom-up approaches are often presented as a remedy to environmental governance problems caused by poorly aligned social institutions and fragmented ecosystems. However, there is a lack of empirical evidence demonstrating how such social-ecological fit might emerge and help achieve desirable outcomes. This paper combines quantitative social-ecological network analysis with interviews to investigate whether bottom-up approaches in lake governance improve the fit. Read More

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http://dx.doi.org/10.1007/s13280-019-01163-4DOI Listing

Status and trends of terrestrial arthropod abundance and diversity in the North Atlantic region of the Arctic.

Ambio 2019 Mar 16. Epub 2019 Mar 16.

Arctic Research Centre, Aarhus University, Ny Munkegade 114, bldg. 1540, 8000, Aarhus C, Denmark.

The Circumpolar Biodiversity Monitoring Programme (CBMP) provides an opportunity to improve our knowledge of Arctic arthropod diversity, but initial baseline studies are required to summarise the status and trends of planned target groups of species known as Focal Ecosystem Components (FECs). We begin this process by collating available data for a relatively well-studied region in the Arctic, the North Atlantic region, summarising the diversity of key terrestrial arthropod FECs, and compiling trends for some representative species. We found the FEC classification system to be challenging to implement, but identified some key groups to target in the initial phases of the programme. Read More

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http://dx.doi.org/10.1007/s13280-019-01162-5DOI Listing

Wildlife, human and environmental costs of using lead ammunition: An economic review and analysis.

Ambio 2019 Mar 16. Epub 2019 Mar 16.

Wildfowl & Wetlands Trust, Slimbridge, Gloucestershire, GL2 7BT, UK.

A proposed European Union (EU)-wide restriction on the use of lead gunshot for shooting in and over wetlands estimated that the societal benefits of a restriction outweighed costs, despite few identified benefits being quantified economically. A subsequent Annex XV Investigation Report on the evidence of impacts of lead ammunition in terrestrial environments concluded that additional measures to control its use are warranted, although to date this has not been further evaluated. To help inform this process, we review the literature and undertake new analyses to estimate the costs of continued use of lead ammunition associated with impacts on wildlife, people and the environment. Read More

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http://link.springer.com/10.1007/s13280-019-01157-2
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http://dx.doi.org/10.1007/s13280-019-01157-2DOI Listing
March 2019
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Using green infrastructure to improve urban air quality (GI4AQ).

Ambio 2019 Mar 16. Epub 2019 Mar 16.

Birmingham Institute for Forest Research and School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

As evidence for the devastating impacts of air pollution on human health continues to increase, improving urban air quality has become one of the most pressing tasks facing policy makers world-wide. Increasingly, and very often on the basis of conflicting and/or weak evidence, the introduction of green infrastructure (GI) is seen as a win-win solution to urban air pollution, reducing ground-level concentrations without imposing restrictions on traffic and other polluting activities. The impact of GI on air quality is highly context dependent, with models suggesting that GI can improve urban air quality in some situations, but be ineffective or even detrimental in others. Read More

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http://dx.doi.org/10.1007/s13280-019-01164-3DOI Listing

Effects of lead from ammunition on birds and other wildlife: A review and update.

Ambio 2019 Mar 16. Epub 2019 Mar 16.

Department of Zoology, University of Cambridge, David Attenborough Building, Pembroke Street, Cambridge, CB2 3QZ, UK.

Poisoning of wild birds following ingestion of lead from ammunition has long been recognised and considerable recent research has focused on terrestrial birds, including raptors and scavengers. This paper builds upon previous reviews and finds that both the number of taxa affected and geographical spread of cases has increased. Some lead may also be absorbed from embedded ammunition fragments in injured birds which risk sub-lethal and welfare effects. Read More

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http://dx.doi.org/10.1007/s13280-019-01159-0DOI Listing

Pre- and post-transplant ponatinib for a patient with acute megakaryoblastic blast phase chronic myeloid leukemia with T315I mutation who underwent allogeneic hematopoietic stem cell transplantation.

Int J Hematol 2019 Mar 16. Epub 2019 Mar 16.

Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.

A 42-year-old female complaining of fever and night sweats was diagnosed with acute megakaryoblastic blast phase chronic myeloid leukemia (CML-BP). She had massive splenomegaly, left pleural effusion with leukemia infiltration, and moderate myelofibrosis. She received dasatinib monotherapy (140 mg/day) as for induction, after which her pleural effusion rapidly resolved and hematological remission was achieved. Read More

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http://dx.doi.org/10.1007/s12185-019-02628-8DOI Listing

Comparative Evaluation of Median Versus Youden Index Dichotomization Methods: Exposure-Response Analysis of Mycophenolic Acid and Acyl-Glucuronide Metabolite.

Eur J Drug Metab Pharmacokinet 2019 Mar 16. Epub 2019 Mar 16.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.

Background And Objectives: Dichotomization of pharmacokinetic exposure measures in exposure-response relationship studies provides results that are interpretable in clinical care. Several methods exist in the literature on how to define the cut-off values needed for the dichotomization process. Commonly, the sample median is utilized to define the dichotomizing value; however, statistical methods based on the exposure metric and its association with the outcome are argued to result in a more proper definition of the optimal cut-point. Read More

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http://dx.doi.org/10.1007/s13318-019-00550-2DOI Listing

Molecular detection and phylogeny of bovine viral diarrhea virus 1 among cattle herds from Northeast, Southeast, and Midwest regions, Brazil.

Braz J Microbiol 2019 Mar 16. Epub 2019 Mar 16.

Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

We examined the circulating BVDV species and genotypes among cattle herds from Northeast, Southeast, and Midwest regions in Brazil. A total of 77 animals tested positive through standard PCR. Phylogenetic analyses revealed the presence of BVDV-1a, highlighting the need for better surveillance strategies to prevent BVDV spread in the country. Read More

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http://dx.doi.org/10.1007/s42770-019-00064-8DOI Listing

Toothbrushing training programme using an iPad for children and adolescents with autism.

Eur Arch Paediatr Dent 2019 Mar 16. Epub 2019 Mar 16.

Centre de Recherche en Education de Nantes, EA2661, Chemin de la Censive du Tertre, BP 81227, 44312, Nantes Cedex 3, France.

Aim: To improve the oral health of children and teenagers with autism spectrum disorder (ASD) by using an iPad-based training programme.

Methods: Fifty-two children and teenagers with ASD (aged 3-19 years) educated in schools or in care centres participated in this cohort study and followed for 8 months. A training programme for teaching toothbrushing behaviours was proposed to the educational staff. Read More

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http://dx.doi.org/10.1007/s40368-018-0396-yDOI Listing

Reaction times of children having nitrous oxide inhalation sedation for dental procedures.

Eur Arch Paediatr Dent 2019 Mar 16. Epub 2019 Mar 16.

Department of Paediatric Dentistry, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background: Inhalation sedation (IHS), using nitrous oxide and oxygen, is a commonly used form of pharmacological behaviour management in paediatric dentistry. Previous studies suggest that IHS causes a delay in reaction time, which recovers to baseline within 10 min.

Aim: To observe the reaction times (RT) of children before and after undergoing IHS for dental treatment. Read More

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http://dx.doi.org/10.1007/s40368-019-00433-9DOI Listing

Growing up with Fragile X Syndrome: Concerns and Care Needs of Young Adult Patients and Their Parents.

J Autism Dev Disord 2019 Mar 16. Epub 2019 Mar 16.

ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Room SP-1536, Wytemaweg 80, 3015CN, Rotterdam, The Netherlands.

Little is known about care needs of young adults with Fragile X Syndrome (FXS). Patient-driven information is needed to improve understanding and support of young adults with FXS. A qualitative study was performed in 5 young adult patients (aged 18-30), and 33 parents of young adults. Read More

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http://dx.doi.org/10.1007/s10803-019-03973-7DOI Listing

Social Decision Making in Autistic Adolescents: The Role of Theory of Mind, Executive Functioning and Emotion Regulation.

J Autism Dev Disord 2019 Mar 16. Epub 2019 Mar 16.

Division of Psychology and Language Sciences, University College London, London, UK.

Social decision making is often challenging for autistic individuals. Twenty autistic adolescents made decisions in the socially interactive context of a one-shot ultimatum game, and performance was compared to a large matched typical reference sample. Theory of mind, executive functioning and emotion regulation were measured via direct assessments, self- and parent report. Read More

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http://dx.doi.org/10.1007/s10803-019-03975-5DOI Listing

Building Skills, Confidence, and Wellness: Psychosocial Effects of Soft Skills Training for Young Adults with Autism.

J Autism Dev Disord 2019 Mar 16. Epub 2019 Mar 16.

Department of Rehabilitation Sciences, Florida Gulf Coast University, Fort Myers, FL, USA.

Recognizing that social functioning and mental health are linked to social participation and employment outcomes, this pilot study examined the preliminary outcomes of an eight-session, work-related social skills training program designed for young adults with high-functioning autism (HFASD). Results indicate statistically significant improvements in social cognition, social function, and social confidence. Furthermore, participants (n = 26) reported statistically significant reductions in anxiety, and a trend toward lessening depressive symptoms. Read More

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http://dx.doi.org/10.1007/s10803-019-03962-wDOI Listing

Switching "Real-World" Diabetes Patients to Degludec from Other Basal Insulins Provides Different Clinical Benefits According to Their Baseline Glycemic Control.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

eSwiss Medical and Surgical Center, St Gallen, Switzerland.

Introduction: The stable, ultra-long duration of action of insulin degludec (degludec) minimizes fluctuations in glucose-lowering activity over the daily (24-h) dosing period, and comparative studies with other basal insulins suggest that these properties translate into a lower risk of hypoglycemia at equivalent levels of glycemic control. Results from the real-world European multicenter, retrospective chart review study of 2550 patients with type 1 and type 2 diabetes (T1D and T2D) in routine clinical care EU-TREAT (NCT02662114) showed that patients benefited from improved glycemic control and significantly reduced rates of hypoglycemia following a switch to degludec.

Methods: In this post hoc analysis, EU-TREAT patients were stratified into good (≤ 7. Read More

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http://dx.doi.org/10.1007/s12325-019-00916-7DOI Listing
March 2019
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Assessing the Role of Anti rh-GAA in Modulating Response to ERT in a Late-Onset Pompe Disease Cohort from the Italian GSDII Study Group.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of Clinical and Experimental Medicine, UOC di Neurologia e Malattie Neuromuscolari, University of Messina, Messina, Italy.

Introduction: Patients with late-onset Pompe disease (LOPD) receiving enzyme replacement therapy (ERT) may develop IgG antibodies against alglucosidase alpha (anti-rhGAA) in the first 3 months of treatment. The exact role of these antibodies in modulating efficacy of ERT in this group of patients is still not fully understood. To assess whether anti rh-GAA antibodies interfere with ERT efficacy, we studied a large Italian cohort of LOPD patients. Read More

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http://dx.doi.org/10.1007/s12325-019-00926-5DOI Listing

Thyroid Cancer Benefits the Prognosis of Ovarian Cancer: A SEER-Based Study.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of General Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China.

Introduction: To explore the effect of a second thyroid cancer (TC) on ovarian cancer (OC) patient survival, we compared OC patients with or without a second primary TC using data from the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: Data for OC only, female TC only and OC patients with a second TC (OC2TC) from two periods, 2000-2014 and 1980-1994, were extracted from the SEER database. Differences in clinicopathological and treatment characteristics were analysed using the chi-square test. Read More

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http://link.springer.com/10.1007/s12325-019-00918-5
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http://dx.doi.org/10.1007/s12325-019-00918-5DOI Listing
March 2019
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Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.

Introduction: There are some controversies about treatment modalities in osteoarthritis (OA), including chondroitin sulfate (CS). The objective of this study was to determine whether CS is effective at alleviating pain and improving function in patients with knee OA and to identify the factors that explain inconsistencies in clinical trial results.

Methods: We conducted a systematic review of randomized, placebo-controlled trials, searching the databases Medline, Cochrane central register for controlled trials and Scopus. Read More

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http://dx.doi.org/10.1007/s12325-019-00921-wDOI Listing

Bloating and Abdominal Distension: Clinical Approach and Management.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Division of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.

Functional abdominal bloating and distension (FABD) are common gastrointestinal complaints, encountered on a daily basis by gastroenterologists and healthcare providers. Functional abdominal bloating is a subjective sensation that is commonly associated with an objective abdominal distension. FABD may be diagnosed as a single entity (the sole or cardinal complaint) or may overlap with other functional gastrointestinal disorders such as functional constipation, irritable bowel syndrome, and functional dyspepsia. Read More

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http://dx.doi.org/10.1007/s12325-019-00924-7DOI Listing

Maximum Tolerated Dose and Pharmacokinetics of Paclitaxel Micellar in Patients with Recurrent Malignant Solid Tumours: A Dose-Escalation Study.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of Oncology, Lund University Hospital, Skåne University Hospital, 221 85, Lund, Sweden.

Introduction: A water-soluble Cremophor EL-free formulation of paclitaxel, in which retinoic acid derivates solubilize paclitaxel by forming micelles (paclitaxel micellar), was studied for the first time in man to establish the maximum tolerated dose (MTD) and to characterize the pharmacokinetics (PK).

Methods: This was an open-label, one-arm, dose-escalating study in patients with advanced solid malignant tumours, for which no standard therapy was available or had failed. Paclitaxel micellar was given as 1-h intravenous infusion every 21 days for 3 cycles, mainly without premedication. Read More

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http://dx.doi.org/10.1007/s12325-019-00909-6DOI Listing

The Case for the Use of Patient and Caregiver Perception of Change Assessments in Rare Disease Clinical Trials: A Methodologic Overview.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Casimir, Plymouth, MA, USA.

Introduction: The traditional model of evaluating treatments based primarily on primary outcome measures has stumbled in its application to rare disease. Rare disease clinical trials face the methodological challenges of small, heterogeneous patient populations and relatively few validated, disease-specific outcome measures. Incorporating qualitative research into rare disease clinical trials may help sponsors, regulators, payers, and prescribers to better understand the real-world and patient-specific impact of a potential therapy. Read More

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http://dx.doi.org/10.1007/s12325-019-00920-xDOI Listing

Survival, Motor Function, and Motor Milestones: Comparison of AVXS-101 Relative to Nusinersen for the Treatment of Infants with Spinal Muscular Atrophy Type 1.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

AveXis, Inc., Bannockburn, IL, USA.

Introduction: Infants with spinal muscular atrophy (SMA) type 1 typically face a decline in motor function and a severely shortened life expectancy. Clinical trials for SMA type 1 therapies, onasemnogene abeparvovec (AVXS-101) and nusinersen, demonstrated meaningful improvements in efficacy (e.g. Read More

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http://dx.doi.org/10.1007/s12325-019-00923-8DOI Listing

Foot-and-mouth disease in Southern Ghana: occurrence and molecular characterization of circulating viruses.

Trop Anim Health Prod 2019 Mar 16. Epub 2019 Mar 16.

OIE Sub-Saharan Africa Regional Reference Laboratory for Foot-and-Mouth Disease, Botswana Vaccine Institute, Private Bag 0031, Gaborone, Botswana.

Foot-and-mouth disease (FMD) is considered to be endemic in Ghana. However, our knowledge of the local epidemiology of the disease is restricted by a lack of serological information and data for characterized viruses causing field outbreaks. In order to improve our understanding of the prevailing situation, this study was initiated to establish the FMD viruses (FMDV) circulating in the country. Read More

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http://dx.doi.org/10.1007/s11250-019-01864-8DOI Listing

Effect of biotin supplementation on milk yield of Girolando cows reared in a tropical climate.

Trop Anim Health Prod 2019 Mar 16. Epub 2019 Mar 16.

Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, GO, 74001-970, Brazil.

The objective of this study was to evaluate the effect of biotin supplementation on milk yield and the reproductive efficiency in Girolando cows. The study was conducted on a dairy farm located in central Brazil, between April 2012 and December 2016. Thirty-six Girolando cows in their first lactation were used. Read More

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http://dx.doi.org/10.1007/s11250-019-01862-wDOI Listing

Issues in Measuring the Healthiness of Food Environments and Interpreting Relationships with Diet, Obesity and Related Health Outcomes.

Curr Obes Rep 2019 Mar 16. Epub 2019 Mar 16.

Global Obesity Centre, Melbourne Burwood Campus, Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, Australia.

Purpose Of Review: There is a broad consensus that policies to create healthier food environments are needed to address obesity. However, previous reviews of the relationships between the healthiness of food environments and diet/obesity-related outcomes have typically reported either mixed associations or none at all. This paper aimed to synthesise measurement and interpretation issues in this field, based on findings from previous reviews. Read More

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http://dx.doi.org/10.1007/s13679-019-00342-4DOI Listing

The relationship between diabetic retinopathy and psychosocial functioning: a systematic review.

Qual Life Res 2019 Mar 16. Epub 2019 Mar 16.

Singapore Eye Research Institute (SERI), The Academia, 20 College Road, Level 6, Singapore, 169856, Singapore.

Importance: Previous work has reported a link between diabetic retinopathy/diabetic macular edema (DR/DME) and psychosocial functioning, although the extent and direction of the association remains uncertain.

Objective: To determine the relationship between DR/DME and psychosocial functioning, the latter an umbrella term used to capture the emotional and social aspects of functioning which may include, for example, depression; depressive disorder; anxiety; vision-specific distress; diabetes-specific distress and emotional and social well-being.

Evidence Review: PubMed, Embase, Medline and the Cochrane Central register were systematically searched for relevant interventional and observational quantitative studies using standardised criteria. Read More

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http://dx.doi.org/10.1007/s11136-019-02165-1DOI Listing

Human Endothelial Colony Forming Cells Express Intracellular CD133 that Modulates their Vasculogenic Properties.

Stem Cell Rev 2019 Mar 16. Epub 2019 Mar 16.

Sorbonne Paris Cité, Université Paris Descartes, Paris, France.

Stem cells at the origin of endothelial progenitor cells and in particular endothelial colony forming cells (ECFCs) subtype have been largely supposed to be positive for the CD133 antigen, even though no clear correlation has been established between its expression and function in ECFCs. We postulated that CD133 in ECFCs might be expressed intracellularly, and could participate to vasculogenic properties. ECFCs extracted from cord blood were used either fresh (n = 4) or frozen (n = 4), at culture days <30, to investigate the intracellular presence of CD133 by flow cytometry and confocal analysis. Read More

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http://dx.doi.org/10.1007/s12015-019-09881-8DOI Listing

Anaesthetic Factors Affecting Outcome After Bariatric Surgery, a Retrospective Levelled Regression Analysis.

Obes Surg 2019 Mar 16. Epub 2019 Mar 16.

Department of General Surgery, AZ Sint Jan Brugge-Oostende, B-8000, Brugge, Belgium.

Background: Deep neuromuscular block (NMB) and opioid-free anaesthesia (OFA) improve surgical workspace and reduce post-operative opioid consumption, but its impact on perioperative outcomes is unknown. This observational study compared complications and healthcare resource utilization after bariatric surgery, with or without continuous deep NMB or OFA.

Methods: We included all 9246 patients who underwent laparoscopic bariatric surgery at our institution from January 2009 to February 2017. Read More

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http://dx.doi.org/10.1007/s11695-019-03763-1DOI Listing

Utilization of the CRISPR-Cas9 Gene Editing System to Dissect Neuroinflammatory and Neuropharmacological Mechanisms in Parkinson's Disease.

J Neuroimmune Pharmacol 2019 Mar 16. Epub 2019 Mar 16.

Parkinson's Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.

Chronic and debilitating neurodegenerative diseases, such as Parkinson's disease (PD), impose an immense medical, emotional, and economic burden on patients and society. Due to a complex interaction between genetic and environmental risk factors, the etiology of PD remains elusive. However, the cumulative evidence emerging from clinical and experimental research over the last several decades has identified mitochondrial dysfunction, oxidative stress, neuroinflammation, and dysregulated protein degradation as the main drivers of PD neurodegeneration. Read More

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http://dx.doi.org/10.1007/s11481-019-09844-3DOI Listing

ACTN4 Promotes the Proliferation, Migration, Metastasis of Osteosarcoma and Enhances its Invasive Ability through the NF-κB Pathway.

Pathol Oncol Res 2019 Mar 16. Epub 2019 Mar 16.

Department of Orthopedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

Alpha-actinin-4 (ACTN4) is associated with different types of tumors, but its role in osteosarcoma (OS) is not known. We aimed to investigate the effect of ACTN4 on the growth, migration, invasion and metastasis of OS. We further explored the possible mechanism of how ACTN4 affects the development of OS. Read More

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http://dx.doi.org/10.1007/s12253-019-00637-wDOI Listing

Congenital Chylothorax in a Neonate with Cornelia de Lange Syndrome: A Rare Complication Managed with a Novel Indigenously Prepared Milk Formulation.

Indian J Pediatr 2019 Mar 16. Epub 2019 Mar 16.

Department of Maternal and Reproductive Health, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Congenital chylothorax is a relatively uncommon condition seen in newborn period. Treatment comprises of adequate pleural fluid drainage, octreotide infusion, total parenteral nutrition followed by medium chain triglyceride (MCT) based low fat milk preparations. The authors present a case of Cornelia de Lange syndrome with a rare presentation of antenatally diagnosed chlyothorax presenting at birth with respiratory distress. Read More

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http://dx.doi.org/10.1007/s12098-019-02908-5DOI Listing

Lymphopenia and Severe Combined Immunodeficiency (SCID) - Think Before You Ink.

Indian J Pediatr 2019 Mar 16. Epub 2019 Mar 16.

Department of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohematology (ICMR), Mumbai, Maharashtra, India.

Objectives: Severe combined immunodeficiency (SCID) represents one of the most severe forms of Primary immunodeficiency (PID) disorders, characterized by T cell lymphopenia (TCL) and lack of cellular and humoral immune responses. However, not all patients with low T cell lymphocyte counts may have an abnormal T cell immunity and the observed TCL may be a temporary suppression resulting from transient lymphopenia secondary to severe infections. In such cases, it is necessary to estimate the severity of the observed TCL by assessing thymic capabilities. Read More

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http://dx.doi.org/10.1007/s12098-019-02904-9DOI Listing

Divergent responses of bacterial activity, structure, and co-occurrence patterns to long-term unbalanced fertilization without nitrogen, phosphorus, or potassium in a cultivated vertisol.

Environ Sci Pollut Res Int 2019 Mar 16. Epub 2019 Mar 16.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China.

Unbalanced fertilization lacking nitrogen (N), phosphorus (P), or potassium (K) is a worldwide phenomenon; however, whether they affect bacterial community composition and intraspecific interactions in a similar pattern and how they affect bacterial activity are not systematically compared. Soils under different kinds of unbalanced fertilization in a 21-year field experiment were collected to investigate the variation in dehydrogenase activity (DHA), bacterial community diversity, structure, composition, and possible interactions. Compared to the balanced fertilization of NPK, the DHA from unbalanced fertilization of NP, PK, and NK was 8. Read More

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http://dx.doi.org/10.1007/s11356-019-04839-2DOI Listing

Constructed wetland microcosms as sustainable technology for domestic wastewater treatment: an overview.

Environ Sci Pollut Res Int 2019 Mar 16. Epub 2019 Mar 16.

Department of Environmental Science (DES), School of Environmental Science (SES), Babasaheb Bhimrao Ambedkar (A Central) University, Lucknow, UP, 226025, India.

Constructed wetland microcosms (CWMs) are artificially designed ecosystem which utilizes both complex and ordinary interactions between supporting media, macrophytes, and microorganisms to treat almost all types of wastewater. CWMs are considered as green and sustainable techniques which require lower energy input, less operational and maintenance cost and provide critical ecological benefits such as wildlife habitat, aquaculture, groundwater recharge, flood control, recreational uses, and add aesthetic value. They are good alternatives to conventional treatment systems particularly for smaller communities as well as distant and decentralized locations. Read More

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http://dx.doi.org/10.1007/s11356-019-04816-9DOI Listing

Individual and combined toxicity of carboxylic acid functionalized multi-walled carbon nanotubes and benzo a pyrene in lung adenocarcinoma cells.

Environ Sci Pollut Res Int 2019 Mar 16. Epub 2019 Mar 16.

School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Co-exposure to carboxylic acid functionalized multi-walled carbon nanotubes (F-MWCNTs) and polycyclic aromatic hydrocarbons (PAHs) such as benzo a pyrene (BaP) in ambient air have been reported. Adsorption of BaP to F-MWCNTs can influence combined toxicity. Studying individual toxicity of F-MWCNTs and BaP might give unrealistic data. Read More

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http://dx.doi.org/10.1007/s11356-019-04795-xDOI Listing

Polychlorinated naphthalene emissions to the atmosphere from typical secondary aluminum smelting plants in southwestern China: concentrations, characterization, and risk evaluation.

Environ Sci Pollut Res Int 2019 Mar 16. Epub 2019 Mar 16.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

Secondary aluminum smelting industry, as an important source of polychlorinated naphthalene (PCN) in environment, has been concerned in recent years. To figure out the emission characteristics of PCNs and the potential influence on surrounding environment, two typical secondary aluminum smelting plants were selected and PCNs were determined in flue gas, fly ash, aluminum slag, soil, and air samples collected at and around the plants by GC-MS coupled with DFS. PCN emission factors from the flue gas of the two plants (mean 0. Read More

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http://dx.doi.org/10.1007/s11356-019-04744-8DOI Listing

Is vitamin D deficiency predictor of complications development in patients with HCV-related cirrhosis?

Intern Emerg Med 2019 Mar 16. Epub 2019 Mar 16.

Medicina Interna ed Epatologia, Dipartimento di Promozione della Salute, Materno-infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", PROMISE, Università di Palermo, Palermo, Italy.

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http://dx.doi.org/10.1007/s11739-019-02072-wDOI Listing

Metaphyseal cones and sleeves in revision total knee arthroplasty: Two sides of the same coin? Complications, clinical and radiological results-a systematic review of the literature.

Musculoskelet Surg 2019 Mar 16. Epub 2019 Mar 16.

Clinica Ortopedica - Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, GE, Italy.

Revision total knee arthroplasty (rTKA) is increasing of relevance in orthopaedic surgeon daily practice and this trend is likely to continue in the years ahead. The aim of this systematic review of English literature is to summarize and compare indications, complications, clinical and radiological results of metaphyseal cones and sleeves in management of bone loss in rTKA. Retrospective or prospective studies with at least 1 year of follow-up (FU) were included. Read More

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http://dx.doi.org/10.1007/s12306-019-00598-yDOI Listing
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