27,689,164 results match your criteria Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases[Journal]

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Factor XIII Prevents Pulmonary Emboli in Mice by Stabilizing Deep Vein Thrombi.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

Background:  Deep vein thrombosis (DVT) can lead to pulmonary embolism (PE), but the mechanisms responsible for this progression are unknown. Previously, we showed that inhibition of thrombin-mediated activation of factor (F) XIII promotes venous thrombus stability in a murine model.

Aim:  In this study, we investigate the consequence of attenuating fibrinolysis, using FXIII, α-antiplasmin (α-AP) or ε-aminocaproic acid (EACA) supplementation, on clot lysis and venous thrombus stability using the same mouse model. Read More

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http://dx.doi.org/10.1055/s-0039-1685141DOI Listing
April 2019
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Comparison of Two Thrombin Generation Methods, CAT and ST-Genesia, in Liver Transplant Patients.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

CHU Bordeaux, Laboratoire d'Hématologie - PTRR, Hôpital Pellegrin, Bordeaux, France.

Background:  During liver transplantation (LT), thrombin generation (TG) is altered. The most frequently used assay for TG is the Calibrated Automated Thrombogram (CAT). It is designed for series of plasmas and is semi-automated. Read More

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http://dx.doi.org/10.1055/s-0039-1685452DOI Listing

The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIbα-Mediated Platelet Aggregation.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.

The direct thrombin inhibitor (DTI) dabigatran is a non-vitamin K antagonist oral anticoagulant for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. In addition to its anti-thrombotic efficacy, dabigatran has been suggested to exert some pro-thrombotic effect due to fostering the ligation of thrombin to its high affinity platelet receptor glycoprotein (GP) Ibα in patients with atrial fibrillation. On the other hand, we provided evidence that a member of another class of DTIs, lepirudin, stimulates the inhibitory cyclic guanosine monophosphate (cGMP)/soluble guanylate cyclase pathway in human platelets. Read More

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http://dx.doi.org/10.1055/s-0039-1685139DOI Listing

Neutrophil and Monocyte Counts in Heparin-Induced Thrombocytopenia.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Background:  Heparin-induced thrombocytopenia (HIT) antibodies activate platelets, monocytes and neutrophils. Despite these findings, it is unknown whether white blood cell (WBC) counts, including neutrophils and monocytes, are altered during HIT.

Materials And Methods:  We evaluated changes in total WBC counts (including WBC subsets), in 50 post-cardiac surgery patients with serologically confirmed HIT (30 patients with HIT-associated thrombosis). Read More

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http://dx.doi.org/10.1055/s-0039-1683913DOI Listing
April 2019
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Effects of Ultra-Low-Dose Aspirin in Thrombosis and Haemorrhage.

Homeopathy 2019 Apr 20. Epub 2019 Apr 20.

Laboratoire d'Hématologie, UFR des Sciences Pharmaceutiques, Université de Bordeaux, Bordeaux, France.

Background:  Aspirin is the oldest and possibly the most widely used pharmacologically active substance still used in allopathic medicine. Its effect on fever and inflammation has paved the way to its anti-thrombotic effect. Dilutions of aspirin have been tested for many years in the University of Bordeaux, in humans as well as in animal models. Read More

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http://dx.doi.org/10.1055/s-0038-1677495DOI Listing

Mu opioid receptors in the medial habenula contribute to naloxone aversion.

Neuropsychopharmacology 2019 Apr 20. Epub 2019 Apr 20.

McGill University, Faculty of Medicine, Douglas Research Centre, Montreal, Canada.

The medial habenula (MHb) is considered a brain center regulating aversive states. The mu opioid receptor (MOR) has been traditionally studied at the level of nociceptive and mesolimbic circuits, for key roles in pain relief and reward processing. MOR is also densely expressed in MHb, however, MOR function at this brain site is virtually unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0395-7DOI Listing

Opposing effects of an atypical glycinergic and substance P transmission on interpeduncular nucleus plasticity.

Neuropsychopharmacology 2019 Apr 20. Epub 2019 Apr 20.

Department of Psychiatry and NYU Neuroscience Institute, NYU Langone Medical Center, New York, NY, USA.

The medial habenula-interpeduncular nucleus (MHb-IPN) pathway has recently been implicated in the suppression of fear memory. A notable feature of this pathway is the corelease of neurotransmitters and neuropeptides from MHb neurons. Our studies in mice reveal that an activation of substance P-positive dorsomedial habenula (dMHb) neurons results in simultaneous release of glutamate and glycine in the lateral interpeduncular nucleus (LIPN). Read More

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http://dx.doi.org/10.1038/s41386-019-0396-6DOI Listing

Early life antecedents of positive child health among 10-year-old children born extremely preterm.

Pediatr Res 2019 Apr 20. Epub 2019 Apr 20.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objective: To identify modifiable antecedents during pre-pregnancy and pregnancy windows associated with a positive child health at 10 years of age.

Study Design: Data on 889 children enrolled in the Extremely Low Gestational Age Newborn (ELGAN) study in 2002-2004 were analyzed for associations between potentially modifiable maternal antecedents during pre-pregnancy and pregnancy time windows and a previously described positive child health index (PCHI) score at 10 years of age. Stratification by race was also investigated for associations with investigated antecedents. Read More

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http://www.nature.com/articles/s41390-019-0404-x
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http://dx.doi.org/10.1038/s41390-019-0404-xDOI Listing
April 2019
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Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.

Eur J Med Chem 2019 Apr 12;173:203-212. Epub 2019 Apr 12.

Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. Electronic address:

Due to the complexity of the pathogenesis of Parkinson's disease (PD), multimodal treatment may achieve better results. In this study, a series of coumarin Mannich base derivatives were designed and synthesized as multifunctional agents for PD treatment. Among the derivatives, 3-(3-(dimethylamino)propanoyl)-7-hydroxy-5-methyl- 2H-chromen-2-one hydrochloride (24) exhibited the most potent and selective hMAO-B inhibitory activity, and anti-inflammatory and neuroprotective effects in the in vitro studies. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.016DOI Listing

Mass energy absorption coefficients and energy responses of magnesium tetraborate dosimeters for 0.02 MeV to 20 MeV photons using Monte Carlo simulations.

Appl Radiat Isot 2019 Apr 13;148:232-239. Epub 2019 Apr 13.

Departamento de Física, Universidade Federal de Sergipe (UFS), São Cristóvão, SE, Brazil. Electronic address:

Thermoluminescence dosimeters containing boron, such as magnesium tetraborate (MgBO), are of interest because of their very high sensitivity, near tissue-equivalent absorption coefficients, low cost, easy handling, and very large linearity range for absorbed dose. Another important parameter that should be considered when working with thermoluminescent dosimeter (TLD) is the mass energy absorption coefficient (μ/ρ), which is a close approximation to the energy available for production of chemical, biological and other effects associated with exposure to ionizing radiation, therefore important in estimating dose in medical and health physics. In this study the mass energy absorption coefficients and energy responses of undoped and some doped magnesium tetraborates were calculated by Monte Carlo N-particle transport code for a range of photon energies between 20 keV and 20 MeV. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.04.015DOI Listing

Effect of microplastics exposure on the photosynthesis system of freshwater algae.

J Hazard Mater 2019 Apr 12;374:219-227. Epub 2019 Apr 12.

Department of Environmental Science and Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian, 361021, China; Institute of Environmental and Resources Technology, Huaqiao University, Xiamen, 361021, China.

Microplastics are widely distributed in freshwater environments. At present, most of the studies on the toxicity of microplastics are concentrated on aquatic feeding animals, but relatively few have addressed freshwater algae. This study investigated the effect of microplastics (polypropylene (PP) and polyvinyl chloride (PVC)) exposure on the photosynthetic system of freshwater algae over the logarithmic growth period. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.039DOI Listing

Stereoisomer-specific occurrence, distribution, and fate of chiral brominated flame retardants in different wastewater treatment systems in Hong Kong.

J Hazard Mater 2019 Apr 13;374:211-218. Epub 2019 Apr 13.

State Key Laboratory of Marine Pollution (SKLMP), Research Centre for the Oceans and Human Health, Shenzhen Key Laboratory for the Sustainable Use of Marine Biodiversity, City University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Chemistry, City University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address:

This study investigated the occurrence and fate of 1,2,5,6,9,10-hexabromocyclododecane (HBCD) and 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (TBECH), two chiral brominated flame retardants (BFRs) with sixteen different stereoisomers, in four Hong Kong wastewater treatment plants (WWTPs) featuring diverse treatment processes during a two-year sampling campaign. More effective HBCD removal was achieved via biodegradation as compared to sludge sorption, whereas both chemically enhanced primary treatment and secondary treatment yielded high TBECH elimination (>90%). α-HBCD (54-75%) predominated in all samples, and its proportions were increased in effluent as compared to influent and sludge. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.041DOI Listing

Acute cerebellar stroke and middle cerebral artery stroke exert distinctive modifications on functional cortical connectivity: A comparative study via EEG graph theory.

Clin Neurophysiol 2019 Apr 6;130(6):997-1007. Epub 2019 Apr 6.

Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Neurology, Area of Neuroscience, Catholic University of The Sacred Heart, Rome, Italy.

Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms.

Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193011
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http://dx.doi.org/10.1016/j.clinph.2019.03.017DOI Listing
April 2019
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Endpoint accuracy of goal-directed ankle movements correlates to over-ground walking in stroke.

Clin Neurophysiol 2019 Apr 13;130(6):1008-1016. Epub 2019 Apr 13.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.

Objectives: Goal-directed movements are essential for voluntary motor control. The inability to execute precise goal-directed movements after stroke can impair the ability to perform voluntary functions, learn new skills, and hinder rehabilitation. However, little is known about how the accuracy of single-joint, goal-directed ankle movements relates to multi-joint, lower limb function in stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193012
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http://dx.doi.org/10.1016/j.clinph.2019.03.030DOI Listing
April 2019
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Levetiracetam-induced a new seizure type in a girl with a novel SV2A gene mutation.

Clin Neurol Neurosurg 2019 Mar 28;181:64-66. Epub 2019 Mar 28.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; The Beijing Key Laboratory of Neuromodulation, Beijing 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorder, Beijing 100069, China; Department of Pediatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address:

The target brain binding site of levetiracetam (LEV) is synaptic vesicle glycoprotein 2A (SV2A). Up to now, only a homozygous pathogenic SV2A gene mutation was reported in human. We now report a novel heterozygous pathogenic SV2A gene mutation both in a girl and her mother result in epilepsy and poor response to LEV. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193008
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http://dx.doi.org/10.1016/j.clineuro.2019.03.020DOI Listing
March 2019
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A case report of an asymptomatic male child with multiple entero-enteric fistulae post multiple magnet ingestion.

Int J Surg Case Rep 2019 Apr 9;58:50-53. Epub 2019 Apr 9.

Pediatric Surgery Department, Cairo University Specialized Pediatric Hospital, Cairo, Egypt.

Introduction: Foreign body ingestion cases are very common in children. They usually present with obvious symptoms allowing proper diagnosis and management; however, magnet ingestion can be asymptomatic. This disorder is considered uncommon as well as challenging to diagnose before complications of intestinal obstruction or peritonitis occur due to entrapment of intestinal walls in the magnetic field. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.043DOI Listing

Pancreatoduodenectomy in patient with perforated duodenal diverticulum and peritonitis: Case report.

Int J Surg Case Rep 2019 Apr 10;58:48-49. Epub 2019 Apr 10.

Department of Surgery, Summa Akron City Hospital, Akron, Ohio, United Staes; Northeastern Ohio Medical University, Roostown, Ohio, United Staes. Electronic address:

Introduction: Duodenal diverticula are quite prevalent in general population, seen on up to 5% of radiology studies and up to 22% of autopsy examinations.

Presentation Of The Case: 70 years old female was admitted to the hospital with epigastric pain, fevers and elevated white cell count. Abdominal CT scan demonstrated evidence of perforated duodenal diverticulitis which failed to improve with IV antibiotics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193019
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http://dx.doi.org/10.1016/j.ijscr.2019.04.011DOI Listing
April 2019
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A case report of a thymic neuroblastoma associated with syndrome of inappropriate secretion of antidiuretic hormone: Ten-year follow-up results after surgical treatment.

Authors:
Yukitoshi Satoh

Int J Surg Case Rep 2019 Apr 5;58:45-47. Epub 2019 Apr 5.

Department of Thoracic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara-shi, Kanagawa 252-0374, Japan. Electronic address:

Introduction: Thymic neuroblastoma with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in adults is an extremely rare and malignant neoplasm. Although the tumor is known to grow rapidly and have a poor prognosis, its etiology is still uncertain. In 2009, we described a case of thymic neuroblastoma with SIADH. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.056DOI Listing

Oxytocin in the tumor microenvironment is associated with lower inflammation and longer survival in advanced epithelial ovarian cancer patients.

Psychoneuroendocrinology 2019 Apr 6;106:244-251. Epub 2019 Apr 6.

Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, United States.

Background: Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has anti-inflammatory properties that have not been examined in cancer. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.007DOI Listing
April 2019
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An optimized analytical method for cellular targeted quantification of primary metabolites in tricarboxylic acid cycle and glycolysis using gas chromatography-tandem mass spectrometry and its application in three kinds of hepatic cell lines.

J Pharm Biomed Anal 2019 Apr 12;171:171-179. Epub 2019 Apr 12.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Energy synthesis in aerobic organisms relies on two major metabolic pathways, i.e. tricarboxylic acid (TCA) cycle and glycolysis, the metabolites of which are highly affected by many diseases. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.022DOI Listing

Cortical thickness correlates of cognitive performance in cognitively-matched individuals with and without schizophrenia.

Brain Cogn 2019 Apr 17;132:129-137. Epub 2019 Apr 17.

Department of Psychology, York University, Toronto, ONT, Canada.

Schizophrenia is characterized by psychosis and, in most cases, cognitive impairment. It is unclear, however, whether these elements of the disorder represent distinct or related disease processes. Accordingly, this study investigated 3-way interactions between group, cognition and cortical thickness in cognitively-matched patients with schizophrenia and healthy control groups. Read More

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http://dx.doi.org/10.1016/j.bandc.2019.04.003DOI Listing

Cell wall mannoprotein of Candida albicans polarizes macrophages and affects proliferation and apoptosis through activation of the Akt signal pathway.

Int Immunopharmacol 2019 Apr 17;72:308-321. Epub 2019 Apr 17.

Department of Dermatology, The First Hospital of China Medical University, Shenyang 110001, PR China; Key Lab of Dermatology, Ministry of Education and Public Health, National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang 110001, PR China. Electronic address:

Candida albicans is a commensal fungus that associates with human hosts. Under normal circumstances this interaction does not produce any severe life-threatening disease, as macrophages of the innate immune system will result in its clearance. However, disorders may arise in immunosuppressed individuals. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.032DOI Listing

Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.

Int Immunopharmacol 2019 Apr 17;72:301-307. Epub 2019 Apr 17.

First Clinical Hospital of Harbin Medical University, Harbin 150001, China. Electronic address:

Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridonin. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.006DOI Listing

Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.

Int Immunopharmacol 2019 Apr 17;72:292-300. Epub 2019 Apr 17.

Department of Immunology, Medical College of Nanchang University, Nanchang 330000, China. Electronic address:

Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA) rats and the pharmacological mechanism. In the present study, CIA rats were established by injecting bovine type II collagen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193079
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http://dx.doi.org/10.1016/j.intimp.2019.04.027DOI Listing
April 2019
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Imiquimod enhances DNFB mediated contact hypersensitivity in mice.

Int Immunopharmacol 2019 Apr 17;72:284-291. Epub 2019 Apr 17.

Department of Immunology, Basic Medical College of Qingdao University, Qingdao 266071, China.

Imiquimod (Imiq) is a synthetic imizoquinoline compound which can act on Toll-like receptor (TLR)7 and transduce signals involved in cell activation. We investigated the role of Imiq on contact hypersensitivity (CHS) and explored the potential mechanisms of mast cells involved in the process. Topical application of Imiq cream augmented DNFB mediated CHS in C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.025DOI Listing

Candida albicans-induced acute lung injury through activating several inflammatory signaling pathways in mice.

Int Immunopharmacol 2019 Apr 17;72:275-283. Epub 2019 Apr 17.

Department of Infectious Diseases, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; Anhui Center for Surveillance of Bacterial Resistance, Hefei 230032, China. Electronic address:

Candida albicans infection-induced acute lung injury is one of the most prevalent diseases in immunosuppressive individual. Nevertheless, the mechanism by which Candida albicans induced acute lung injury remains unclear. The present study investigated the mechanism by which Candida albicans induced acute lung injury in mice. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.026DOI Listing

Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization.

Int Immunopharmacol 2019 Apr 17;72:264-274. Epub 2019 Apr 17.

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei, China. Electronic address:

Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To investigate the effects and possible mechanism of EVs in UC treatment, we established an in vitro model using lipopolysaccharide (LPS)-treated macrophages and an in vivo dextran sulfate sodium (DSS)-induced mouse model to mimic UC. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.020DOI Listing

The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells.

Phytomedicine 2019 Feb 26;58:152879. Epub 2019 Feb 26.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan, Taiwan, ROC; Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC. Electronic address:

Background: Anti-angiogenesis is an important strategy of psoriasis treatment, but the side effects of systemic agents remain difficult to overcome. Topical use of indigo naturalis ointment has been proved to improve the skin lesion of psoriasis effectively and safely and one of its major components, tryptanthrin, has been demonstrated to have anti-angiogenic effect. Apelin, which has been reported to act as an angiogenic factor that could stimulate the proliferation and migration of vascular endothelial cells and proved to be elevated in psoriasis patients, is a potential target of anti-angiogenic therapy. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.152879DOI Listing
February 2019

Matrix metalloproteinase inhibitors prevent the release and proteolytic activity of monocyte/macrophage-derived microparticles.

Pharmacol Rep 2019 Jan 31;71(3):485-490. Epub 2019 Jan 31.

Department of Pharmacy, University of Pisa, Pisa, Italy.

Background: The role of monocyte/macrophage-derived microparticles (MPs) in the pathophysiology of cancer and chronic inflammatory diseases has been reported; nevertheless, the mechanism underlying microparticles release is currently unclear. The aim of the current study was to investigate whether matrix metalloproteinase (MMP) inhibitors could prevent MP shedding from stimulated human monocyte/macrophage.

Methods: Microparticles were obtained by isolated peripheral blood mononuclear cells after stimulation with the calcium ionophore, A23187. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.013DOI Listing
January 2019

Neck muscle fatigue affects performance of an eye-hand tracking task.

J Electromyogr Kinesiol 2019 Apr 10;47:1-9. Epub 2019 Apr 10.

Faculty of Health Sciences, University of Ontario Institute of Technology, 2000 Simcoe St. North, Oshawa, ON L1H 7K4, Canada. Electronic address:

Altered afferent input from the neck due to fatigue alters upper limb proprioception and is likely to impact upper limb performance accuracy. This study examined the effect of cervical extensor muscle (CEM) fatigue on eye-hand tracking accuracy in healthy participants. Twenty-four healthy right-handed individuals were randomly assigned to either a control or CEM fatigue group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10506411183048
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http://dx.doi.org/10.1016/j.jelekin.2019.04.001DOI Listing
April 2019
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Factors affecting knee abduction during weight-bearing activities in individuals with anterior cruciate ligament reconstruction.

Phys Ther Sport 2019 Apr 12;38:8-15. Epub 2019 Apr 12.

School of Exercise Science, Australian Catholic University, Brisbane, Australia.

Objective: To investigate if muscle strength and muscle activation patterns are associated with increased knee abduction during two functional tasks, commonly used in rehabilitation for individuals with anterior cruciate ligament reconstruction (ACLR).

Design: Cross-sectional study.

Setting: Laboratory. Read More

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http://dx.doi.org/10.1016/j.ptsp.2019.04.006DOI Listing

YY1 regulates cancer cell immune resistance by modulating PD-L1 expression.

Drug Resist Updat 2019 Apr 9;43:10-28. Epub 2019 Apr 9.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, United States. Electronic address:

Recent advances in the treatment of various cancers have resulted in the adaptation of several novel immunotherapeutic strategies. Notably, the recent intervention through immune checkpoint inhibitors has resulted in significant clinical responses and prolongation of survival in patients with several therapy-resistant cancers (melanoma, lung, bladder, etc.). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13687646193001
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http://dx.doi.org/10.1016/j.drup.2019.04.001DOI Listing
April 2019
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Unsupervised tumor detection in Dynamic PET/CT imaging of the prostate.

Med Image Anal 2019 Apr 6;55:27-40. Epub 2019 Apr 6.

School of Computer Science, Tel Aviv University, Tel Aviv, Israel.

Early detection and localization of prostate tumors pose a challenge to the medical community. Several imaging techniques, including PET, have shown some success. But no robust and accurate solution has yet been reached. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13618415183030
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http://dx.doi.org/10.1016/j.media.2019.04.001DOI Listing
April 2019
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Effect of single and combined chemical and physical treatments on the survival of Salmonella and Escherichia coli O157:H7 attached to Valencia oranges.

Int J Food Microbiol 2019 Apr 12;300:22-30. Epub 2019 Apr 12.

Departamentos de Farmacobiología y Matemáticas, CUCEI, Universidad de Guadalajara, Guadalajara, Jalisco 44430, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.04.001DOI Listing

Cerebral cortex impairment in neuromyelitis optica spectrum disorder: A case report and literature review.

Mult Scler Relat Disord 2019 Apr 6;32:9-12. Epub 2019 Apr 6.

Department of Neurology, Chinese PLA General Hospital, Beijing, China. Electronic address:

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder of the central nervous system that usually presents with acute myelitis and/or optic neuritis. Cortical lesions used to be regarded as "red flags" of NMOSD, and indicated the possibility of alternative diagnoses. We recently had reported a NMOSD patient with weakness in both lower limbs resulting from cortical damage, which was usually attributed to spinal cord lesions. Read More

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http://dx.doi.org/10.1016/j.msard.2019.04.005DOI Listing

Episodic memory and learning rates in amyotrophic lateral sclerosis without dementia.

Cortex 2019 Mar 19;117:257-265. Epub 2019 Mar 19.

Neurodegenerative Disease Unit, Department of Clinical Research in Neurology, University of Bari "Aldo Moro", Lecce, Italy; Neurodegenerative Disease Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy. Electronic address:

In amyotrophic lateral sclerosis (ALS), memory deficits may be primary or secondary to executive dysfunction. We assessed episodic memory and executive function of nondemented ALS patients, comparing episodic memory profiles and learning rates of ALS patients with those of mild cognitive impairment (MCI) subjects and cognitively healthy controls (HC). In a multidisciplinary tertiary centre for motor neuron disease, 72 nondemented ALS patients, 57 amnestic MCI (aMCI), 89 single non amnestic MCI with compromised executive functions (dysexecutive MCI), and 190 HC were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00109452193010
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http://dx.doi.org/10.1016/j.cortex.2019.03.003DOI Listing
March 2019
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No evidence for altered up- and downregulation of brain activity in visual cortex during illusory shape perception in autism.

Cortex 2019 Mar 26;117:247-256. Epub 2019 Mar 26.

Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

Autism spectrum disorder (ASD) may be marked by an altered balance between sensory input and prior expectations. Because many illusions rely on integrating sensory input with prior information such as spatial context, individuals with ASD may therefore be less susceptible to visual illusions than typically developing (TD) individuals. Yet empirical evidence on the matter is rather divergent, varying depending on the type of illusion, study procedure, and population. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.03.011DOI Listing

Neural organization of speech production: A lesion-based study of error patterns in connected speech.

Cortex 2019 Mar 7;117:228-246. Epub 2019 Mar 7.

University of South Carolina, Department of Communication Sciences and Disorders, United States.

While numerous studies have explored single-word naming, few have evaluated the behavioral and neural correlates of more naturalistic language, like connected speech, which we produce every day. Here, in a retrospective analysis of 120 participants at least six months following left hemisphere stroke, we evaluated the distribution of word errors (paraphasias) and associated brain damage during connected speech (picture description) and object naming. While paraphasias in connected speech and naming shared underlying neural substrates, analysis of the distribution of paraphasias suggested that lexical-semantic load is likely reduced during connected speech. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.02.029DOI Listing
March 2019
3 Reads

Pattern matching analysis of electron backscatter diffraction patterns for pattern centre, crystal orientation and absolute elastic strain determination - accuracy and precision assessment.

Ultramicroscopy 2019 Apr 15;202:87-99. Epub 2019 Apr 15.

Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK.

Pattern matching between target electron backscatter patterns (EBSPs) and dynamically simulated EBSPs was used to determine the pattern centre (PC) and crystal orientation, using a global optimisation algorithm. Systematic analysis of error and precision with this approach was carried out using dynamically simulated target EBSPs with known PC positions and orientations. Results showed that the error in determining the PC and orientation was <10 of pattern width and <0. Read More

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http://dx.doi.org/10.1016/j.ultramic.2019.04.006DOI Listing

A hybrid genetic-Levenberg Marquardt algorithm for automated spectrometer design optimization.

Ultramicroscopy 2019 Mar 15;202:100-106. Epub 2019 Mar 15.

Science and Math Cluster, Singapore University of Technology and Design, 8 Somapah Road, S487372, Singapore.

Advancements in computational tools have driven increasingly automated, simulation-centric approaches in the design and optimization of spectroscopic electron-optical systems. These augmented methodologies accelerate the optimization process, and can yield better-performing instruments. While classical gradient-based methods had been explored, modern alternatives such as genetic algorithms have rarely been applied. Read More

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http://dx.doi.org/10.1016/j.ultramic.2019.03.004DOI Listing

Discovery of cycloneolignan enantiomers from Isatis indigotica Fortune with neuroprotective effects against MPP-induced SH-SY5Y cell injury.

Bioorg Chem 2019 Apr 15;88:102926. Epub 2019 Apr 15.

School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

A pair of new cycloneolignan enantiomers (1a and 1b) were isolated from the leaves of Isatis indigotica Fortune. Their structures were elucidated by extensive spectroscopic data analysis, including 1D and 2D NMR, HRESIMS, MS/MS analysis, together with theoretical electronic circular dichroism (ECD) calculations. Compounds 1a and 1b were then evaluated for their neuroprotective effects against MPP-induced SH-SY5Y cell injury. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102926DOI Listing

Biochar-red clay composites for energy efficiency as eco-friendly building materials: Thermal and mechanical performance.

J Hazard Mater 2019 Mar 20;373:844-855. Epub 2019 Mar 20.

Department of Architecture and Architectural Engineering, Yonsei University, Seoul 03722, Republic of Korea. Electronic address:

Biochar and red clay were used to develop eco-friendly building materials with improved thermal and mechanical performance. Rice husk, coconut shell, and bamboo were prepared by thermally decomposing as biochar. Thermal conductivity measurements, scanning electron microscopy imaging, compressive strength measurements, and an infrared heat transfer experiment were performed, and the results showed that the mixture of biochar tends to lower the thermal conductivity. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.03.079DOI Listing

A novel environmental-friendly and safe unpacking powder without magnesium, aluminum and sulphur for fireworks.

J Hazard Mater 2019 Apr 2;373:835-843. Epub 2019 Apr 2.

State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, China.

A novel environmental-friendly unpacking powder for fireworks which has no sulfur, no magnesium, no aluminum or their alloys has been prepared in this study: potassium perchlorate (75%), potassium hydrogen terephthalate (13%), micronano porous silicon (9%), carbon (2%), ferrocene (1%). The PM2.5 and PM10 were collected by the ambient air particulate sampler, and the gas product was tested with a smoke analyzer and gas chromatograph to investigate its environmental-friendly performance. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.04.001DOI Listing

Standalone direct pumping photovoltaic system or energy storage in batteries for supplying irrigation networks. Cost analysis.

Sci Total Environ 2019 Apr 7;673:821-830. Epub 2019 Apr 7.

ITA, Dept. Hydraulic and Environmental Engineering, Universitat Politècnica de València.

Solar photovoltaic systems have become one of the most popular topics in the water management industry. Moreover, irrigation networks are water- and energy-hungry, and utility managers are likely to adapt water consumption (and consequently energy demand) to the hours in which there is energy availability. In countries such as Spain (with high irradiance values), solar energy is an available green alternative characterised by zero electricity costs and significantly lower environmental impact. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.050DOI Listing

Graphene oxide induces cardiovascular defects in developing zebrafish (Danio rerio) embryo model: In-vivo toxicity assessment.

Sci Total Environ 2019 Apr 8;673:810-820. Epub 2019 Apr 8.

Center for Biofluid and Biomimic Research, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea. Electronic address:

Graphene oxide (GO) has wide engineering applications in various areas, including electronics, energy storage, pharmaceuticals, nanomedicine, environmental remediation and biotechnology, because of its unique physico-chemical properties. In the present study, the risk-related information of GO was evaluated to examine the potential ecological and health risks of developmental toxicity. Although the overall developmental toxicity of GO has been well characterized in zebrafish, however, its release effect at a certain concentration of living organisms with specific cardiovascular defects remains largely elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193160
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.082DOI Listing
April 2019
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Long-distance influence of the Rhône River plume on the marine benthic ecosystem: Integrating descriptive ecology and predictive modelling.

Sci Total Environ 2019 Apr 3;673:790-809. Epub 2019 Apr 3.

RTE (Réseau de Transport d'Electricité), France.

The Gulf of Lions (GoL) is among the most productive areas of the Mediterranean Sea, with the Rhône River contributing with as much as 90% of the liquid and solid materials (including anthropogenic chemicals) reaching the area. In this paper, we assessed whether classical descriptive ecology and MaxEnt predictive species distribution modelling were able to provide complementary information when analysing the long-distance influence of the river discharges on the GoL benthic ecosystem. Samples were collected in August 2014 from 12 stations covering the sedimentary plain of the deep submarine delta, from the Gulf of Fos to Gruissan. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.010DOI Listing

An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma.

Eur J Cancer 2019 Apr 17;114:1-7. Epub 2019 Apr 17.

Department of Surgical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, the Netherlands.

The sentinel lymph node (SLN) biopsy is a highly accurate staging procedure and the most important prognostic factor in melanoma patients. The European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group aimed to design an updated evolved SLN protocol for the histopathological workup and reporting. We herein recommend extending the distance between steps according to the short axis dimension of the lymph node and optimise both conventional sectioning and staining procedures including immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.03.010DOI Listing

Are 'low socioeconomic status' and 'religiousness' barriers to minority women's use of contraception? A qualitative exploration and critique of a common argument in reproductive health research.

Midwifery 2019 Mar 25;75:59-65. Epub 2019 Mar 25.

Department of Women's and Children's Health (IMCH), Uppsala University, 751 85 Uppsala, Sweden.

Objective: 'Low socioeconomic status' and 'religiousness' appear to have gained status as nearly universal explanatory models for why women in minority groups are less likely to use contraception than other women in the Scandinavian countries. Through interviews with pious Muslim women with immigrant background, living in Denmark and Sweden, we wanted to gain empirical insights that could inform a discussion about what 'low socioeconomic status' and 'religiousness' might mean with regard to women's reproductive decisions.

Design: Semi-structured interviews were conducted in Denmark and Sweden between 2013 and 2016. Read More

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http://dx.doi.org/10.1016/j.midw.2019.03.017DOI Listing

A state-of-the-art review on badminton lunge attributes.

Comput Biol Med 2019 Apr 6;108:213-222. Epub 2019 Apr 6.

School of Mechanical Engineering, Engineering Campus, Universiti Sains Malaysia, 14300, Nibong Tebal, Penang, Malaysia. Electronic address:

Good badminton lunge skills have been quantitatively described using biomechanical attributes at both static and dynamic phases. The measurement of badminton lunge attributes has often been complicated by various experimental protocols used. No review article has considered or critically reviewed the attributes that align with badminton lunge performance. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.04.003DOI Listing
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