5,535 results match your criteria Journal of clinical psychopharmacology[Journal]


A Long-Term, Open-Label Study to Evaluate the Safety and Tolerability of Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder.

J Clin Psychopharmacol 2019 May/Jun;39(3):203-209

H. Lundbeck A/S, Valby, Denmark.

Background: Long-term treatment is recommended in major depressive disorder (MDD) to prevent relapse and to restore functioning. The aim of this study (Orion; NCT01360866) was to assess the long-term safety, tolerability, and efficacy of open-label treatment with adjunctive brexpiprazole in adult patients with MDD.

Methods: Patients rolled over into this 52-week study (amended to 26 weeks) from 3 randomized, double-blind, placebo-controlled studies. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001034DOI Listing
April 2019
10 Reads

Benzodiazepine Abuse in Attention-Deficit Disorder?

Authors:
Richard Balon

J Clin Psychopharmacol 2019 May/Jun;39(3):291

Departments of Psychiatry and Behavioral Neurosciences and Anesthesiology, Wayne State University School of Medicine, Detroit,

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http://dx.doi.org/10.1097/JCP.0000000000001043DOI Listing

Bipolar Disorder in a Young Woman With Preexisting Rapid-Onset Dystonia-Parkinsonism and Successful Treatment With Clozapine and Lithium.

J Clin Psychopharmacol 2019 May/Jun;39(3):277-279

Child Neuropsychiatry Unit, Department of Neuroscience, IRCCS Children Hospital Bambino GesùRome, Italy Child Neuropsychiatry Unit, Department of Neuroscience, IRCCS Children Hospital Bambino GesùRome, Italy and Department of Human Sciences, "Sapienza" University of Rome, Rome, Italy Child Neuropsychiatry Unit, Department of Neuroscience, IRCCS Children Hospital Bambino GesùRome, Italy.

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http://dx.doi.org/10.1097/JCP.0000000000001045DOI Listing
April 2019
2 Reads

Insulin Resistance-Related Proteins Are Overexpressed in Patients and Rats Treated With Olanzapine and Are Reverted by Pueraria in the Rat Model.

J Clin Psychopharmacol 2019 May/Jun;39(3):214-219

Institute of Psychiatry and Neuroscience, Xin Xiang Medical University, Xinxiang, Henan.

Background: Olanzapine, a commonly used second-generation antipsychotic, causes severe metabolic adverse effects, such as elevated blood glucose and insulin resistance (IR). Previous studies have proposed that overexpression of CD36, GGPPS, PTP-1B, GRK2, and adipose triglyceride lipase may contribute to the development of metabolic syndrome, and Pueraria could eliminate the metabolic adverse effects. The study aimed to investigate the association between olanzapine-associated IR and IR-related proteins (IRRPs) and determine the role of Pueraria in protection against the metabolic adverse effects of olanzapine. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001028DOI Listing
April 2019
3 Reads

Acute Psychosis Related to Baclofen in a Patient Treated for Binge Eating Disorder Highlights the Urgent Need to Regulate Off-Label Prescriptions.

J Clin Psychopharmacol 2019 May/Jun;39(3):282-284

CHU Lille, Department of Psychiatry, and Addiction Medicine, Lille, France CHU Lille, Department of Psychiatry, and Addiction Medicine, Lille, France, Univ. Lille, INSERM U1171 'Degenerative and Vascular Cognitive Disorders,' Lille, France, CHU Lille, Department of PharmacologyLille, France and CHU Lille, Addictovigilance CenterLille, France CHU Lille, Department of Psychiatry, and Addiction Medicine, Lille, France and Univ. Lille, CNRS UMR 9193, SCALab PsyCHIC Team, Lille, France Univ. Lille, INSERM U1171 'Degenerative and Vascular Cognitive Disorders,' Lille, France, CHU Lille, Department of PharmacologyLille, France and CHU Lille, Addictovigilance CenterLille, France Univ. Lille, INSERM U1171 'Degenerative and Vascular Cognitive Disorders,' Lille, France, CHU Lille, Department of Pharmacology, Lille, France and CHU Lille, Addictovigilance Center, Lille, France Univ. Lille, INSERM U1171 'Degenerative and Vascular Cognitive Disorders,' Lille, France, CHU Lille, Department of Pharmacology, Lille, France and CHU Lille, Addictovigilance and Pharmacovigilance Center, Lille, France CHU Lille, Department of Psychiatry and Addiction Medicine, Lille, France and Univ. Lille, CNRS UMR 9193, SCALab PsyCHIC Team, Lille, France.

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http://dx.doi.org/10.1097/JCP.0000000000001044DOI Listing
April 2019
1 Read

Systematic Review of Gender Bias in the Clinical Trials of New Long-Acting Antipsychotic Drugs.

J Clin Psychopharmacol 2019 May/Jun;39(3):264-272

Hospital Pharmacy Department, University Hospital Virgen del Rocío, Seville, Spain.

Purpose/background: This article evaluates gender bias in the published clinical trials of new long-acting antipsychotics.

Methods/procedures: We conducted a review of controlled clinical trials of the new prolonged-release antipsychotics (aripiprazole, risperidone, or paliperidone) for the treatment of schizophrenia published in MEDLINE over the last 10 years and available in full text in English. The study followed the corresponding international recommendations. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001041DOI Listing
April 2019
2 Reads

Clozapine-Associated Kidney Injury Complicated by Lithium Toxicity: A Case Report and Literature Review.

Authors:
Benjamin DeLucia

J Clin Psychopharmacol 2019 May/Jun;39(3):273-275

Department of Psychiatry, State University of New York at Stony Brook, Stony Brook, NY

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http://dx.doi.org/10.1097/JCP.0000000000001042DOI Listing
April 2019
3 Reads

Characterization of the Safety and Pharmacokinetic Profile of D-Methadone, a Novel N-Methyl-D-Aspartate Receptor Antagonist in Healthy, Opioid-Naive Subjects: Results of Two Phase 1 Studies.

J Clin Psychopharmacol 2019 May/Jun;39(3):226-237

Relmada Therapeutics, Inc, New York, NY.

Purpose/background: N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonists are potential agents for the treatment of several central nervous system disorders including major depressive disorder. Racemic methadone, L-methadone, and D-methadone all bind the NMDAR with an affinity similar to that of established NMDAR antagonists, whereas only L-methadone and racemic methadone bind to opioid receptors with high affinity. Therefore, D-methadone is expected to have no clinically significant opioid effects at therapeutic doses mediated by its NMDAR antagonism. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001035DOI Listing
April 2019
2 Reads

Clonazepam-Related Paradoxical Behavioral Disinhibition: An Uncommon But Grave Adverse Effect.

J Clin Psychopharmacol 2019 May/Jun;39(3):281-282

Psychiatry Service, Louis Stokes VA Medical Center, Cleveland, OH, Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes VA Medical Center, Cleveland, OH and Case Western Reserve University, Cleveland, OH Psychiatry Service, Louis Stokes VA Medical Center, Cleveland, OH and Department of Psychiatry, Case Western Reserve University, Cleveland, OH Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes VA Medical Center, Cleveland, OH and Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals, Case Western Reserve University, Cleveland, OH.

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http://dx.doi.org/10.1097/JCP.0000000000001037DOI Listing
April 2019
1 Read

Description of the Treatment Course by Pregabalin for Anxiety in Patients With a Major Neurocognitive Disorder.

J Clin Psychopharmacol 2019 May/Jun;39(3):261-263

Background: Anxiety symptoms frequently experienced by patients with a major neurocognitive disorder (NCD) are often treated with long-term benzodiazepines despite known adverse effects. Pregabalin has shown efficacy in generalized anxiety disorders but has not been studied in patients with a major NCD. The objective of this study was to describe the use of pregabalin for anxiety in patient with a major NCD and the impact of its use on the pharmacological treatment change. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001029DOI Listing
April 2019
1 Read

Zolpidem and Gender: Are Women Really At Risk?

J Clin Psychopharmacol 2019 May/Jun;39(3):189-199

the Sleep Disorders and Research Center, Henry Ford Health System, Detroit MI.

Background: In 2013 the Food and Drug Administration (FDA) claimed the existence of new data showing women to be at risk for excessive daytime sedation and impaired driving proficiency following bedtime doses of zolpidem. The putative explanation was the reduced metabolic clearance of zolpidem and higher morning blood concentrations in women compared to men. The FDA acted to reduce the recommended dosage for women down to 50% of the dose for men. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001026DOI Listing
April 2019
2 Reads

Longitudinally Measured Changes in Somnolence Severity With a Visual Analog Scale in a Randomized Lithium Versus Quetiapine-IR Study in Bipolar Disorder.

J Clin Psychopharmacol 2019 May/Jun;39(3):249-253

Department of Psychiatry, Hongkou District Mental Health Center of Shanghai, Shanghai, China.

Objective: The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder.

Methods: A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measured with a VAS from 0 to 100 (VAS based), and somnolence frequency was recorded according to incident report (incidence based) at each visit. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001031DOI Listing
April 2019
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Agomelatine Effectiveness, Tolerability, and Impact on Anhedonia in Major Depression: A Pooled Analysis.

J Clin Psychopharmacol 2019 May/Jun;39(3):288-290

Department of Neuroscience Imaging and Clinical Sciences, University "G d'Annunzio," Chieti, Italy Department of Neuroscience Imaging and Clinical Sciences, University "G d'Annunzio," Chieti, Italy Department of Neuroscience Imaging and Clinical Sciences, University "G d'Annunzio," Chieti, Italy Department of Psychiatry, First Faculty of Medicine, Charles University and General University, Hospital in Prague, Czech Republic University Psychiatric Clinic Ljubljana, Slovenia Department of Neuroscience Imaging and Clinical Sciences, University "G d'Annunzio," Chieti, Italy Department of Medical Sciences, University of Ferrara, Italy.

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http://dx.doi.org/10.1097/JCP.0000000000001038DOI Listing
April 2019
2 Reads

Immediate-Release Methylphenidate-Associated Recurrent Nasal Bleeding in Siblings.

J Clin Psychopharmacol 2019 May/Jun;39(3):284-285

Department of Psychiatry, Faculty of Medicine, University of Kelaniya, Sri Lanka and School of Rural Health, Faculty of Medicine Nursing and Health Sciences, Monash University, Australia Consultation Liaison Psychiatry, Latrobe Regional Hospital, Australia.

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http://dx.doi.org/10.1097/JCP.0000000000001033DOI Listing
April 2019
2 Reads

Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers.

J Clin Psychopharmacol 2019 May/Jun;39(3):238-242

Department of Psychiatry, University Hospital Brno, Faculty of Medicine Masaryk University, Brno, Czech Republic.

Background: Lithium in the form of lithium carbonate (Li2CO3) has become one of the most effective and widely prescribed drugs for mood stabilization. However, lithium has adverse effects on renal tubular functions, such as decreased concentrating function of the kidneys, and even occasional symptoms of nephrogenous diabetes insipidus occur with additional evidence of glomerular disruption in lithium-treated patients.

Methods: We assessed the kidney function of patients with bipolar disorder who are under long-term lithium treatment using novel markers of kidney damage such as plasma neutrophil gelatinase-associated lipocalin, cystatin C, albuminuria, estimated glomerular filtration rate, Chronic Kidney Disease-Epidemiology Investigation using creatinine and cystatin C, and serum and urinary osmolality, and compared the results with those of age-matched patients with bipolar disorder not treated with lithium. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001030DOI Listing
April 2019
3 Reads

The Course of Adverse Events in Venlafaxine XR Treatment in Generalized Anxiety Disorder.

J Clin Psychopharmacol 2019 May/Jun;39(3):258-260

Department of General Studies, Harcum College, Media, PA.

Purpose: The time course of adverse events is an important factor for patient management. Clinicians are better able to prepare patients for specific adverse events, which leads to better treatment adherence.

Methods: Adverse events were followed longitudinally for 6 months during the open-label phase of a relapse prevention trial with 264 patients with generalized anxiety disorder. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001027DOI Listing
April 2019
2 Reads

Effect of Sertraline, Dosulepin, and Venlafaxine on Non-BDNF Neurotrophins in Patients With Depression: A Cohort Study.

J Clin Psychopharmacol 2019 May/Jun;39(3):220-225

From the Department of Pharmacology and Psychiatry, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.

Background: The neurotrophic hypothesis of depression has been mostly studied with a focus on brain-derived neurotrophic factor (BDNF) leading to lack of data on non-BDNF neurotrophins (NTs). The aim of this study was to evaluate the effect of antidepressant drugs on changes in serum nerve growth factor (NGF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4).

Methods: A prospective cohort study was conducted on 105 patients with depression who were subgrouped to the group 1 (mild and moderate depression without somatic syndrome treated with sertraline), group 2 (mild and moderate depression with somatic syndrome treated with dosulepin), and group 3 (severe depression without psychotic symptoms treated with venlafaxine). Read More

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http://dx.doi.org/10.1097/JCP.0000000000001022DOI Listing
April 2019
1 Read

Life-Threatening Angioedema Following Varenicline Administration.

J Clin Psychopharmacol 2019 May/Jun;39(3):285-287

Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan and College of Medicine, Chang Gung University, Taoyuan, Taiwan School of Medicine, International Medical University, Kuala Lumpur, Malaysia and Sarawak General Hospital, Kuching, Sarawak, Malaysia Sarawak General Hospital, Kuching, Sarawak, Malaysia Department of Emergency Medicine, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan and College of Medicine, Chang Gung University, Taoyuan, Taiwan

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http://dx.doi.org/10.1097/JCP.0000000000001036DOI Listing
March 2019
2 Reads

Clozapine-Associated Myoclonus and Stuttering Secondary to Smoking Cessation and Drug Interaction: A Case Report.

J Clin Psychopharmacol 2019 May/Jun;39(3):275-277

Department of Psychiatry, Medstar Georgetown University Hospital, Washington, DC Department of Neurology, Department of Veterans Affairs Medical Center of Washington DC and Department of Neurology, George Washington University Hospital, Washington, DC Department of Psychiatry, Department of Veterans Affairs Medical Center of Washington DC, Department of Psychiatry, George Washington University Hospital, Washington, DC Department of Neurology, Medstar Georgetown University Hospital, Washington, DC

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http://dx.doi.org/10.1097/JCP.0000000000001032DOI Listing

A Randomized, 8-Week Study of the Effects of Extended-Release Paliperidone and Olanzapine on Heart Rate Variability in Patients With Schizophrenia.

J Clin Psychopharmacol 2019 May/Jun;39(3):243-248

Department of Mental Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China.

Purpose: This study aimed to explore the effect of extended-release paliperidone (paliperidone ER) and olanzapine on heart rate variability (HRV) in patients with schizophrenia.

Methods: A total of 106 patients with schizophrenia diagnosed by the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) were randomly divided into the paliperidone ER group or the olanzapine group for an 8-week clinical trial, with 53 patients in each group. The time domain and frequency domain analyses including the SD of all the R-R intervals in 24 hours (SDNN), the SD of the mean value of all the normal R-R intervals in every 5-minute interval within 24 hours (SDANN index), the mean value of the SD of all the normal R-R intervals in every 5-minute interval within 24 hours (SDNN index), the root mean square of successive R-R differences, the percentage of adjacent R-R intervals that differ by more than 50 milliseconds, high-frequency power (HF), low-frequency power (LF), and LF/HF were adopted to assess the HRV of patients at baseline and after treatment for 8 weeks in each group. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001023DOI Listing
March 2019
1 Read

Lithium Augmentation Versus Citalopram Combination in Imipramine-Resistant Major Depression: A 10-Week Randomized Open-Label Study.

J Clin Psychopharmacol 2019 May/Jun;39(3):254-257

Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Biomedical Diagnosis Centre, IDIBAPS, UB, University of Barcelona, Barcelona, Spain.

Purpose/background: According to available international clinical guides, tricyclic antidepressants are our first- or second-line treatment of choice for severe unipolar major depression. However, the therapeutic option after an unsuccessful response to a tricyclic antidepressant drug in unipolar major depression is still unclear.

Methods/procedures: This 10-week randomized open-label study assessed the effectiveness of add-on lithium (adjusted to plasma levels) compared with add-on citalopram (30 mg/d) in 104 severe unipolar major depressive patients after a 10-week unsuccessful imipramine (adjusted to plasma level). Read More

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http://dx.doi.org/10.1097/JCP.0000000000001024DOI Listing

Statistics Commentary Series: Commentary No. 32: Multiple Regression: What Can Possibly Go Wrong?

Authors:
David L Streiner

J Clin Psychopharmacol 2019 May/Jun;39(3):200-202

From the Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton; and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000001040DOI Listing

Effect of Red Yeast Rice on Cognitive Functioning in Schizophrenia: Data From a Pilot Study.

J Clin Psychopharmacol 2019 May/Jun;39(3):210-213

Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Seton Hall University, Nutley, NJ.

Background: Cognitive deficits (CDs) in schizophrenia affect poor outcome and real-world community functioning. Because redox imbalance has been implicated, among other factors, in the pathophysiology of CDs, antioxidant compounds may have a beneficial effect in their treatment. Red yeast rice (RYR), besides its lipid-lowering effect, exhibit antioxidant and anti-inflammatory. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001025DOI Listing

Antidepressant Discontinuation: A Tale of Two Narratives.

Authors:
Ronald W Pies

J Clin Psychopharmacol 2019 May/Jun;39(3):185-188

From the Department of Psychiatry, Tufts University School of Medicine, Boston, MA 02111.

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http://dx.doi.org/10.1097/JCP.0000000000001021DOI Listing

Acute Urinary Retention and Acute Kidney Injury After Duloxetine Treatment: A Rare Case Report.

J Clin Psychopharmacol 2019 May/Jun;39(3):279-281

Department of Internal Medicine, Cüneyt Yildiz State Hospital, Bursa, Turkey Department of Nephrology, Yüksek İhtisas Education Research Hospital, Health Sciences University, Bursa, Turkey Department of Internal Medicine, Yüksek İhtisas Education Research Hospital, Health Sciences University, Bursa, Turkey.

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http://dx.doi.org/10.1097/JCP.0000000000001020DOI Listing
March 2019
1 Read

Low Incidence of Neuroleptic Malignant Syndrome Associated With Paliperidone Palmitate Long-Acting Injectable: A Database Report and Case Study.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):180-182

The Zucker Hillside Hospital Glen Oaks, NY. and The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Glen Oaks, NY The Zucker Hillside Hospital Glen Oaks, NY. The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Glen Oaks, NY and Department of Child and Adolescent Psychiatry Charité Universitätsmedizin Berlin, Germany. Providence Care Hospital Kingston, Ontario, Canada. Janssen Research & Development LLC, Raritan, NJ.

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http://dx.doi.org/10.1097/JCP.0000000000001019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392211PMC
February 2019
1 Read

Methylphenidate-Induced Raynaud Phenomenon Developed After Increasing Methylphenidate in an Adult With Attention-Deficit Hyperactivity Disorder.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):178-179

Department of Orthopaedic SurgeryFaculty of Medicine Siriraj Hospital Mahidol University Bangkok, Thailand. Department of Psychiatry Faculty of Medicine Siriraj Hospital Mahidol University Bangkok, Thailand

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http://dx.doi.org/10.1097/JCP.0000000000001007DOI Listing
February 2019
3 Reads

Venlafaxine Abuse in a Patient With a History of Methylphenidate Abuse: A Case Report.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):172-174

Centre d'Addictovigilance Paca Corse, Service de Pharmacologie Clinique, Hôpital de la Timone, Assistance Publique, Hôpitaux de Marseille, Aix-Marseille Université, Inserm UMR1106, Institut de Neurosciences des Systèmes, Marseille, France Association Nationale de Prévention en, Alcoologie et Addictologie, Bastia, France Centre d'Addictovigilance Paca Corse, Service de Pharmacologie Clinique, Hôpital de la Timone, Assistance Publique, Hôpitaux de Marseille, Aix-Marseille Université, Inserm UMR1106, Institut de Neurosciences des Systèmes, Marseille, France Centre d'Addictovigilance Paca Corse, Service de Pharmacologie Clinique, Hôpital de la Timone, Assistance Publique, Hôpitaux de Marseille, Aix-Marseille Université, Inserm UMR1106, Institut de Neurosciences des Systèmes, Marseille, France,

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http://dx.doi.org/10.1097/JCP.0000000000001011DOI Listing
February 2019

Extended Requirement of Granulocyte Colony-Stimulating Factor for Clozapine-Associated Neutropenia.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):169-172

Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine, Baltimore, MD Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine Baltimore, MD

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http://dx.doi.org/10.1097/JCP.0000000000001017DOI Listing
February 2019
2 Reads

Abrupt Decrease of Clozapine Plasma Concentration After Discontinuation of Flupentixol Comedication.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):168-169

Department of Psychiatry and Psychotherapy University of Leipzig Leipzig, Germany Department of Psychiatry and Psychotherapy University of Leipzig Leipzig, Germany.

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http://dx.doi.org/10.1097/JCP.0000000000001013DOI Listing
February 2019

Clozapine Metabolism in East Asians and Caucasians: A Pilot Exploration of the Prevalence of Poor Metabolizers and a Systematic Review.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):135-144

Department of Clinical and Experimental Medicine, University of Messina, Italy.

Purpose/background: In clozapine therapeutic drug monitoring (TDM) studies, Chinese reached the same concentrations using half the dosage Caucasians use. Defining clozapine poor metabolizers (PMs) requires stratification by ethnicity, smoking, and sex.

Methods/procedures: After sex and smoking stratification in 129 Chinese inpatients (mean, 8. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001018DOI Listing
March 2019
4 Reads

Neuropsychiatric Safety and Efficacy of Varenicline, Bupropion, and Nicotine Patch in Smokers With Psychotic, Anxiety, and Mood Disorders in the EAGLES Trial.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):108-116

Department of Psychiatry, University of California, San Diego, CA.

Background: Neuropsychiatric safety and relative efficacy of varenicline, bupropion, and transdermal nicotine patch (NRT) in those with psychiatric disorders are of interest.

Methods: We performed secondary analyses of safety and efficacy outcomes by psychiatric diagnosis in EAGLES (Evaluating Adverse Events in a Global Smoking Cessation Study), a 12-week, randomized, double-blind, triple-dummy, placebo- and active (NRT)-controlled trial of varenicline and bupropion with 12-week follow-up, in a subset population, n = 4092, with a primary psychotic (n = 390), anxiety (n = 792), or mood (n = 2910) disorder. Primary end-point parameters were incidence of prespecified moderate and severe neuropsychiatric adverse events (NPSAEs) and weeks 9 to 12 continuous abstinence rates (9-12CAR). Read More

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http://dx.doi.org/10.1097/JCP.0000000000001015DOI Listing
March 2019
2 Reads

Article Selected for the Mitchell B. Balter Award 2018.

Authors:

J Clin Psychopharmacol 2019 Mar/Apr;39(2):107

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http://dx.doi.org/10.1097/JCP.0000000000001010DOI Listing
February 2019

Seven Aphorisms About Therapeutic Relationships and Listening.

Authors:
Richard I Shader

J Clin Psychopharmacol 2019 Mar/Apr;39(2):95-96

From the Tufts University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1097/JCP.0000000000001008DOI Listing
February 2019
1 Read

Effects of Curcumin on Cognitive Functioning and Inflammatory State in Schizophrenia: A Double-Blind, Placebo-Controlled Pilot Trial.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):182-184

Department of PsychiatryYale UniversityNew Haven, CT Department of Psychiatry and Psychology School for Mental Health and Neuroscience Maastricht University Medical Center Maastricht, Netherlands and Department of Psychiatry Yale University New Haven, CT Department of Psychiatry Yale University New Haven, CT.

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http://dx.doi.org/10.1097/JCP.0000000000001012DOI Listing
February 2019
4 Reads

Attentional Bias, "Cool" and "Hot" Executive Functions in Obese Patients: Roles of Body Mass Index, Binge Eating, and Eating Style.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):145-152

National Addiction Centre, King's College London, London, United Kingdom.

Purpose/background: Obesity is recognized as an important risk factor for many chronic diseases and is a major health issue. The current study examined attentional bias to food and the "cool" (inhibitory control and mental flexibility) and "hot" (affective decision making) executive functions (EFs) in obese patients preparing for bariatric surgery. In addition to body mass index (BMI), this study examined the impact of the binge-eating tendency and eating styles. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001016DOI Listing
March 2019
1 Read

Effects of Cytochrome P450 2C19 Genetic Polymorphisms on Responses to Escitalopram and Levels of Brain-Derived Neurotrophic Factor in Patients With Panic Disorder.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):117-123

Anding Hospital, Tianjin, China.

Purpose/background: The purpose of this study was to examine the relationships between ytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms, brain-derived neurotrophic factor (BDNF) plasma levels, and treatment responses to escitalopram in Chinese patients with panic disorder (PD).

Methods/procedures: Ninety patients with PD were administered the Panic Disorder Severity Scale-Chinese Version (PDSS-CV) and Hamilton Anxiety Scale (HAMA-14) from baseline to 8 weeks. Escitalopram treatment (10 mg/d) was administered for 8 consecutive weeks. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001014DOI Listing
March 2019
3 Reads
3.243 Impact Factor

Effects of Repeated Intravenous Ketamine in Treatment-Resistant Geriatric Depression: A Case Series.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):158-161

Center for Behavioral Health, Cleveland Clinic, Cleveland, OH.

Purpose: There is an immediate need for more sustainable, effective therapies for treatment-resistant depression in patients who do not respond to traditional psychopharmacology. The aim of this study was to determine the efficacy and safety of intravenous ketamine infusions on the elderly population by using a case series of 6 geriatric patients with treatment-resistant depression.

Methods: Eligible patients aged 65 to 82 were given a subanesthetic ketamine hydrochloride dose of 0. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001006DOI Listing
March 2019
2 Reads

Statistics Commentary Series: Commentary No. 31: The Uses and Misuses of the Analysis of Covariance.

Authors:
David L Streiner

J Clin Psychopharmacol 2019 Mar/Apr;39(2):97-99

From the Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton; and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000001009DOI Listing
February 2019
3 Reads

Pharmacokinetics and Pharmacodynamics of Immediate-Release Versus Extended-Release Guanfacine in Adult Daily Smokers.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):124-128

From the Department of Psychiatry, Yale School of Medicine, New Haven, CT.

Background: Guanfacine is Food and Drug Administration approved for hypertension and attention-deficit hyperactivity disorder and has been used off-label for migraine prophylaxis, heroin withdrawal, and more recently smoking cessation. Previous studies have shown positive effects of 3 mg/d of immediate-release (IR) guanfacine on smoking outcomes, but the dose equivalency of the IR and extended-release (ER) formulations is unknown.

Procedures: A within-subject design was used to compare the pharmacokinetics and pharmacodynamics of 3 mg/d of IR, 4 mg/d of ER, and 6 mg/d of ER guanfacine in adult daily smokers (n = 5). Read More

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http://dx.doi.org/10.1097/JCP.0000000000001004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391212PMC
March 2019
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Twenty-Four-Hour Measures of Heart Rate-Corrected QT Interval, Peak-to-End of the T-Wave, and Peak-to-End of the T-Wave/Corrected QT Interval Ratio During Antipsychotic Treatment.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):100-107

Beasley Pharmaceutical and Biotechnology Consulting, LLC, Indianapolis, IN.

Purpose/background: Prolonged ventricular repolarization, measured by heart rate-corrected QT interval (QTc) prolongation, might be a biomarker for risk of torsade de pointes (TdP) and sudden cardiac death. However, the predictive value of QTc has been challenged, and a component of QTc, peak-to-end of the T-wave (Tpe), and a high Tpe/QT ratio might be superior biomarkers because they better reflect increased transmural dispersion of ventricular myocyte repolarization, which can lead to TDP. The purpose of this pilot study was to provide the first measurements of heart rate, QTc, Tpe, Tpe/QTc, and their variability over 24 hours in medication-free patients with schizophrenia, during treatment with ziprasidone or other antipsychotic drugs, and healthy controls. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001003DOI Listing
March 2019
3 Reads

Milk Thistle Treatment for Children and Adults with Trichotillomania: A Double-Blind, Placebo-Controlled, Crossover Negative Study.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):129-134

Background: Data on the pharmacological treatment of trichotillomania are limited. Milk thistle has antioxidant properties and showed promise in trichotillomania in a prior case report. The goal of the current study was to determine the efficacy and tolerability of silymarin in children and adults with trichotillomania. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420084PMC

Late-Onset Cholestatic Liver Injury During Combination Treatment With Chlorpromazine and Olanzapine: A Case Report.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):175-176

UO Psichiatria ASST-Nord Milano Milan, Italy U.O.C. Psichiatria Azienda Ospedaliera Universitaria Integrata (AOUI) Verona and Section of Psychiatry Department of Neurological Biomedical and Movement Sciences University of Verona Verona, Italy.

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http://dx.doi.org/10.1097/JCP.0000000000000999DOI Listing
January 2019
2 Reads

Ziprasidone Augmentation of SSRI Antidepressants in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Pilot Study of Augmentation Therapy.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):153-157

Background: Posttraumatic stress disorder (PTSD) is often a chronic, disabling illness for which antidepressant medications (ie, SSRI) are considered the primary psychopharmacological treatment. However, many patients remain refractory to antidepressants alone or in combination with psychotherapy. Safe and effective treatments for individuals with refractory PTSD are needed. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001000DOI Listing
March 2019
3 Reads

Dose-Dependent Efficacy of Tandospirone for an Oldest-Old Patient With Behavioral and Psychological Symptoms of Dementia.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):176-178

Department of Neuropsychiatry Ehime University Graduate School of Medicine Shitsukawa, Toon Ehime, Japan Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.

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http://dx.doi.org/10.1097/JCP.0000000000000998DOI Listing
January 2019
3 Reads

Antipsychotic Use During Pregnancy and the Risk of Gestational Diabetes Mellitus: A Systematic Review.

Authors:
Faruk Uguz

J Clin Psychopharmacol 2019 Mar/Apr;39(2):162-167

From the Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Purpose: This study aimed to review the current literature examining a potential relationship between the use of antipsychotic drugs during pregnancy and gestational diabetes mellitus (GDM).

Methods: PubMed was searched for English language reports between January 1, 1996, and March 31, 2018, by using combinations of the following key words: antipsychotics, pregnancy, FGAs, SGAs, GDM, obstetric outcomes, pregnancy outcomes, obstetric complications, maternal complications, clozapine, olanzapine, risperidone, aripiprazole, amisulpirde, ziprasidone, quetiapine, haloperidol, chlorpromazine, zuclopenthixol, and flupenthixol. Studies but not case reports, case series, or reviews published in a peer-reviewed journal were eligible for inclusion. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001002DOI Listing
March 2019
4 Reads

Low-Dose Aripiprazole-Associated Sleepwalking in a Long-Term Zolpidem Treatment Patient With a Depressive Episode: A Case Report.

J Clin Psychopharmacol 2019 Mar/Apr;39(2):174-175

Department of Psychiatry Tri-Service General Hospital National Defense Medical Center Taipei, Taiwan Department of Psychiatry Beitou Branch Tri-Service General Hospital National Defense Medical Center and Graduate Institute of Medical Sciences National Defense Medical Center Taipei, Taiwan

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http://dx.doi.org/10.1097/JCP.0000000000001001DOI Listing
January 2019
4 Reads

Atypical Presentation of Ertapenum-Associated Hallucinations in a Patient With Psychiatric Disease.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):88-89

Creighton University School of Medicine-Phoenix Regional Campus Phoenix, AZ Department of Psychiatry St. Joseph's Hospital and Medical Center Phoenix, AZ

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http://dx.doi.org/10.1097/JCP.0000000000000996DOI Listing
February 2019
8 Reads

Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):67-71

Purpose/background: Loss of gray matter after stroke has been associated with cognitive impairment. This pilot study aimed to investigate the therapeutic potential of lithium, a putative neurotrophic agent, in the stroke recovery process within a year of stroke occurrence.

Methods: Twelve stroke patients (mean ± SD age, 71. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319570PMC
March 2019
11 Reads

Comparison of Paliperidone Palmitate and Second-Generation Oral Antipsychotics in Terms of Medication Adherence, Side Effects, and Quality of Life.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):57-62

From the Department of Psychiatry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Purpose: Although schizophrenia can be treated effectively, acute aggravations and relapses occur often. Antipsychotic drug therapies are fairly effective for decreasing the rate of relapses in patients with schizophrenia. This study aimed to compare paliperidone palmitate and the second-generation oral antipsychotic drugs used to treat patients with schizophrenia in terms of medication adherence, side effects, and quality of life. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000993DOI Listing
March 2019
4 Reads