5,502 results match your criteria Journal of clinical psychopharmacology[Journal]


Seven Aphorisms About Therapeutic Relationships and Listening.

Authors:
Richard I Shader

J Clin Psychopharmacol 2019 Feb 12. Epub 2019 Feb 12.

From the Tufts University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1097/JCP.0000000000001008DOI Listing
February 2019

Effects of Curcumin on Cognitive Functioning and Inflammatory State in Schizophrenia: A Double-Blind, Placebo-Controlled Pilot Trial.

J Clin Psychopharmacol 2019 Feb 8. Epub 2019 Feb 8.

Department of PsychiatryYale UniversityNew Haven, CT Department of Psychiatry and PsychologySchool for Mental Health and NeuroscienceMaastricht University Medical CenterMaastricht, Netherlandsand Department of PsychiatryYale UniversityNew Haven, CT Department of PsychiatryYale UniversityNew Haven, CT.

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http://dx.doi.org/10.1097/JCP.0000000000001012DOI Listing
February 2019
3 Reads

Attentional Bias, "Cool" and "Hot" Executive Functions in Obese Patients: Roles of Body Mass Index, Binge Eating, and Eating Style.

J Clin Psychopharmacol 2019 Feb 7. Epub 2019 Feb 7.

National Addiction Centre, King's College London, London, United Kingdom.

Purpose/background: Obesity is recognized as an important risk factor for many chronic diseases and is a major health issue. The current study examined attentional bias to food and the "cool" (inhibitory control and mental flexibility) and "hot" (affective decision making) executive functions (EFs) in obese patients preparing for bariatric surgery. In addition to body mass index (BMI), this study examined the impact of the binge-eating tendency and eating styles. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001016DOI Listing
February 2019

Effects of Cytochrome P450 2C19 Genetic Polymorphisms on Responses to Escitalopram and Levels of Brain-Derived Neurotrophic Factor in Patients With Panic Disorder.

J Clin Psychopharmacol 2019 Feb 7. Epub 2019 Feb 7.

Anding Hospital, Tianjin, China.

Purpose/background: The purpose of this study was to examine the relationships between ytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms, brain-derived neurotrophic factor (BDNF) plasma levels, and treatment responses to escitalopram in Chinese patients with panic disorder (PD).

Methods/procedures: Ninety patients with PD were administered the Panic Disorder Severity Scale-Chinese Version (PDSS-CV) and Hamilton Anxiety Scale (HAMA-14) from baseline to 8 weeks. Escitalopram treatment (10 mg/d) was administered for 8 consecutive weeks. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001014DOI Listing
February 2019

Effects of Repeated Intravenous Ketamine in Treatment-Resistant Geriatric Depression: A Case Series.

J Clin Psychopharmacol 2019 Feb 7. Epub 2019 Feb 7.

Center for Behavioral Health, Cleveland Clinic, Cleveland, OH.

Purpose: There is an immediate need for more sustainable, effective therapies for treatment-resistant depression in patients who do not respond to traditional psychopharmacology. The aim of this study was to determine the efficacy and safety of intravenous ketamine infusions on the elderly population by using a case series of 6 geriatric patients with treatment-resistant depression.

Methods: Eligible patients aged 65 to 82 were given a subanesthetic ketamine hydrochloride dose of 0. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001006DOI Listing
February 2019

Statistics Commentary Series: Commentary No. 31: The Uses and Misuses of the Analysis of Covariance.

Authors:
David L Streiner

J Clin Psychopharmacol 2019 Feb 4. Epub 2019 Feb 4.

From the Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton; and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000001009DOI Listing
February 2019
3 Reads

Pharmacokinetics and Pharmacodynamics of Immediate-Release Versus Extended-Release Guanfacine in Adult Daily Smokers.

J Clin Psychopharmacol 2019 Jan 30. Epub 2019 Jan 30.

From the Department of Psychiatry, Yale School of Medicine, New Haven, CT.

Background: Guanfacine is Food and Drug Administration approved for hypertension and attention-deficit hyperactivity disorder and has been used off-label for migraine prophylaxis, heroin withdrawal, and more recently smoking cessation. Previous studies have shown positive effects of 3 mg/d of immediate-release (IR) guanfacine on smoking outcomes, but the dose equivalency of the IR and extended-release (ER) formulations is unknown.

Procedures: A within-subject design was used to compare the pharmacokinetics and pharmacodynamics of 3 mg/d of IR, 4 mg/d of ER, and 6 mg/d of ER guanfacine in adult daily smokers (n = 5). Read More

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http://dx.doi.org/10.1097/JCP.0000000000001004DOI Listing
January 2019
1 Read

Twenty-Four-Hour Measures of Heart Rate-Corrected QT Interval, Peak-to-End of the T-Wave, and Peak-to-End of the T-Wave/Corrected QT Interval Ratio During Antipsychotic Treatment.

J Clin Psychopharmacol 2019 Jan 30. Epub 2019 Jan 30.

Beasley Pharmaceutical and Biotechnology Consulting, LLC, Indianapolis, IN.

Purpose/background: Prolonged ventricular repolarization, measured by heart rate-corrected QT interval (QTc) prolongation, might be a biomarker for risk of torsade de pointes (TdP) and sudden cardiac death. However, the predictive value of QTc has been challenged, and a component of QTc, peak-to-end of the T-wave (Tpe), and a high Tpe/QT ratio might be superior biomarkers because they better reflect increased transmural dispersion of ventricular myocyte repolarization, which can lead to TDP. The purpose of this pilot study was to provide the first measurements of heart rate, QTc, Tpe, Tpe/QTc, and their variability over 24 hours in medication-free patients with schizophrenia, during treatment with ziprasidone or other antipsychotic drugs, and healthy controls. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001003DOI Listing
January 2019
2 Reads

Milk Thistle Treatment for Children and Adults with Trichotillomania: A Double-Blind, Placebo-Controlled, Crossover Negative Study.

J Clin Psychopharmacol 2019 Jan 28. Epub 2019 Jan 28.

Background: Data on the pharmacological treatment of trichotillomania are limited. Milk thistle has antioxidant properties and showed promise in trichotillomania in a prior case report. The goal of the current study was to determine the efficacy and tolerability of silymarin in children and adults with trichotillomania. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001005DOI Listing
January 2019

Late-Onset Cholestatic Liver Injury During Combination Treatment With Chlorpromazine and Olanzapine: A Case Report.

J Clin Psychopharmacol 2019 Jan 11. Epub 2019 Jan 11.

UO Psichiatria ASST-Nord Milano Milan, Italy U.O.C. Psichiatria Azienda Ospedaliera Universitaria Integrata (AOUI) Verona and Section of Psychiatry Department of Neurological Biomedical and Movement Sciences University of Verona Verona, Italy.

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http://dx.doi.org/10.1097/JCP.0000000000000999DOI Listing
January 2019
1 Read

Ziprasidone Augmentation of SSRI Antidepressants in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Pilot Study of Augmentation Therapy.

J Clin Psychopharmacol 2019 Jan 10. Epub 2019 Jan 10.

Background: Posttraumatic stress disorder (PTSD) is often a chronic, disabling illness for which antidepressant medications (ie, SSRI) are considered the primary psychopharmacological treatment. However, many patients remain refractory to antidepressants alone or in combination with psychotherapy. Safe and effective treatments for individuals with refractory PTSD are needed. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001000DOI Listing
January 2019
2 Reads

Dose-Dependent Efficacy of Tandospirone for an Oldest-Old Patient With Behavioral and Psychological Symptoms of Dementia.

J Clin Psychopharmacol 2019 Jan 8. Epub 2019 Jan 8.

Department of Neuropsychiatry Ehime University Graduate School of Medicine Shitsukawa, Toon Ehime, Japan Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.

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http://dx.doi.org/10.1097/JCP.0000000000000998DOI Listing
January 2019
2 Reads

Antipsychotic Use During Pregnancy and the Risk of Gestational Diabetes Mellitus: A Systematic Review.

Authors:
Faruk Uguz

J Clin Psychopharmacol 2019 Jan 7. Epub 2019 Jan 7.

From the Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Purpose: This study aimed to review the current literature examining a potential relationship between the use of antipsychotic drugs during pregnancy and gestational diabetes mellitus (GDM).

Methods: PubMed was searched for English language reports between January 1, 1996, and March 31, 2018, by using combinations of the following key words: antipsychotics, pregnancy, FGAs, SGAs, GDM, obstetric outcomes, pregnancy outcomes, obstetric complications, maternal complications, clozapine, olanzapine, risperidone, aripiprazole, amisulpirde, ziprasidone, quetiapine, haloperidol, chlorpromazine, zuclopenthixol, and flupenthixol. Studies but not case reports, case series, or reviews published in a peer-reviewed journal were eligible for inclusion. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001002DOI Listing
January 2019
2 Reads

Low-Dose Aripiprazole-Associated Sleepwalking in a Long-Term Zolpidem Treatment Patient With a Depressive Episode: A Case Report.

J Clin Psychopharmacol 2019 Jan 7. Epub 2019 Jan 7.

Department of Psychiatry Tri-Service General Hospital National Defense Medical Center Taipei, Taiwan Department of Psychiatry Beitou Branch Tri-Service General Hospital National Defense Medical Center and Graduate Institute of Medical Sciences National Defense Medical Center Taipei, Taiwan

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http://dx.doi.org/10.1097/JCP.0000000000001001DOI Listing
January 2019

Atypical Presentation of Ertapenum-Associated Hallucinations in a Patient With Psychiatric Disease.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):88-89

Creighton University School of Medicine-Phoenix Regional Campus Phoenix, AZ Department of Psychiatry St. Joseph's Hospital and Medical Center Phoenix, AZ

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http://dx.doi.org/10.1097/JCP.0000000000000996DOI Listing
December 2018
4 Reads

Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):67-71

Purpose/background: Loss of gray matter after stroke has been associated with cognitive impairment. This pilot study aimed to investigate the therapeutic potential of lithium, a putative neurotrophic agent, in the stroke recovery process within a year of stroke occurrence.

Methods: Twelve stroke patients (mean ± SD age, 71. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319570PMC
December 2018
6 Reads

Comparison of Paliperidone Palmitate and Second-Generation Oral Antipsychotics in Terms of Medication Adherence, Side Effects, and Quality of Life.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):57-62

From the Department of Psychiatry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Purpose: Although schizophrenia can be treated effectively, acute aggravations and relapses occur often. Antipsychotic drug therapies are fairly effective for decreasing the rate of relapses in patients with schizophrenia. This study aimed to compare paliperidone palmitate and the second-generation oral antipsychotic drugs used to treat patients with schizophrenia in terms of medication adherence, side effects, and quality of life. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000993DOI Listing
December 2018
2 Reads

Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):28-38

From the Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, MA.

Purpose/background: Interventions for attention-deficit/hyperactivity disorder (ADHD) may be inadequate for some patients. There is evidence that supplementation with L-methylfolate augments antidepressant agent effects and thus might also augment ADHD treatment effects by a common catecholaminergic mechanism.

Methods: Forty-four adults with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnosis of ADHD participated in a randomized, double-blind, placebo-controlled, 12-week trial of 15 mg of L-methylfolate in combination with osmotic-release oral system methylphenidate. Read More

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http://Insights.ovid.com/crossref?an=00004714-201901000-0000
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http://dx.doi.org/10.1097/JCP.0000000000000990DOI Listing
December 2018
5 Reads

Effect of Brexpiprazole on Prolactin: An Analysis of Short- and Long-Term Studies in Schizophrenia.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):13-19

Otsuka Pharmaceutical Development & Commercialization Inc, Princeton, NJ.

Background: Hyperprolactinemia is an undesirable effect of most antipsychotics because of D2-receptor blockade. We assessed the effect of the D2-receptor partial agonist brexpiprazole on prolactin, based on pooled data from three 6-week, randomized, placebo-controlled studies and two open-label extension studies in patients with schizophrenia.

Methods: In the short-term studies, patients received 0. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319696PMC
December 2018
3 Reads

Editors' Note: Retraction Notice.

Authors:

J Clin Psychopharmacol 2019 Jan/Feb;39(1):45

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http://dx.doi.org/10.1097/JCP.0000000000000952DOI Listing
December 2018
2 Reads

Assessment of the Abuse Potential of Cebranopadol in Nondependent Recreational Opioid Users: A Phase 1 Randomized Controlled Study.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):46-56

Clinical Science Pain, Grünenthal GmbH, Aachen, Germany.

Background: Cebranopadol is a nociceptin/orphanin FQ peptide/opioid receptor agonist with central antinociceptive activity. We hypothesize that this novel mechanism of action may lead to a lower risk of abuse compared with pure μ-opioid peptide receptor agonists.

Methods: We conducted a single-dose, nested-randomized, double-blind crossover study in nondependent recreational opioid users to evaluate the abuse potential of single doses of cebranopadol relative to hydromorphone immediate release and placebo. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319565PMC
December 2018

An 8-Week, Randomized, Phase 2, Double-Blind, Sequential Parallel-Group Comparison Study of Two Dose Levels of the GABAA Positive Allosteric Modulator PF-06372865 Compared With Placebo as an Adjunctive Treatment in Outpatients With Inadequate Response to Standard of Care for Generalized Anxiety Disorder.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):20-27

Pfizer Inc, Cambridge, UK.

Background: Generalized anxiety disorder (GAD) is a common psychiatric disorder, but many patients experience only partial relief of symptoms with existing therapies. Benzodiazepines are effective in many cases but are limited by a number of significant adverse effects. PF-06372865 is a subtype-selective gamma-aminobutyric acid A (GABAA)-positive allosteric modulator lacking in functional activity at alpha 1-containing receptors that are believed to mediate many of these adverse effects. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000997DOI Listing
December 2018
3 Reads

QTc Prolongation Associated With Psychiatric Medications: A Retrospective Cross-Sectional Study of Adult Inpatients.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):72-77

Office of Graduate Medical Education Research, University of Arizona College of Medicine, Phoenix Campus Banner-University Medical Center Phoenix, Phoenix, AZ.

Objective: The aim of our study was to assess the impact of psychiatric medications and concomitant risk factors on the prevalence of QTc prolongation and torsades de pointes (TdP) in hospitalized subjects. We examined the association between individual risk scores and QTc prolongation and proposed an evidence-based protocol for electrocardiogram monitoring on psychotropic medications.

Method: Electrocardiograms (ECGs) of subjects hospitalized over a 1-year period were analyzed for QTc prolongation, associated risk factors, and use of medications. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000992DOI Listing
December 2018
2 Reads

Exploring Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in Obsessive-Compulsive Disorder: A Pilot Study.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):91-93

Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA Department of Psychology, Barnard College and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA New York State Psychiatric Institute, New York, NY Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA Department of Psychology, West Virginia University, Morgantown, WV Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric InstituteNew York, NY Department of Psychiatry, Weill Cornell Medical College, New York, NY Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA,

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http://dx.doi.org/10.1097/JCP.0000000000000994DOI Listing
December 2018
3 Reads

Statistics Commentary Series: Commentary No. 30: Propensity Scores.

Authors:
David L Streiner

J Clin Psychopharmacol 2019 Jan/Feb;39(1):9-12

From the Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton; and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000000991DOI Listing
December 2018
1 Read

Effectiveness of Venlafaxine in Selective Serotonin Reuptake Inhibitor-Resistant Obsessive-Compulsive Disorder: Experience From a Specialty Clinic in India.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):82-85

K.S.Hegde Medical Academy, NITTE, Mangalore, India.

Background: Despite its favorable pharmacological profile and efficacy in major depression and anxiety disorders, evidence for the use of venlafaxine in obsessive-compulsive disorder (OCD) is limited. We sought to examine the real-world effectiveness of venlafaxine from a large database of an OCD clinic in India.

Methods: A total of 1704 consecutive patients who registered at the OCD clinic between June 2014 and December 2016 were evaluated with structured interviews and scales. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000989DOI Listing
December 2018
2 Reads

Switching to Imipramine Versus Add-on Mirtazapine in Venlafaxine-Resistant Major Depression: A 10-Week Randomized Open Study.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):63-66

Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Biomedical Diagnosis Centre, IDIBAPS, UB, University of Barcelona, Barcelona, Spain.

Purpose/background: Newer-generation antidepressants used in monotherapy or in combination with other newer-generation antidepressants or other psychotropic drugs are usually preferred as first- or second-step treatment options in resistant depression. According to our clinical experience, tricyclic antidepressants still are one of our preferred first choices in treatment-resistant moderate to severe unipolar major depressive episodes.

Methods: This 10-week open-design randomized study assessed the effectiveness of switching to imipramine (adjusted to plasma levels) compared with add-on mirtazapine (30 mg/d) for treatment of moderate to severe unipolar major depressive episodes after a 10-week unsuccessful venlafaxine regimen (225-300 mg/d). Read More

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http://dx.doi.org/10.1097/JCP.0000000000000988DOI Listing
December 2018
2 Reads

Clinical Psychopharmacology in Switzerland.

Authors:
Pierre Baumann

J Clin Psychopharmacol 2019 Jan/Feb;39(1):5-8

From the Département de Psychiatrie (DP-CHUV) Université de Lausanne, Prilly-Lausanne, Switzerland.

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http://Insights.ovid.com/crossref?an=00004714-201901000-0000
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http://dx.doi.org/10.1097/JCP.0000000000000985DOI Listing
December 2018
5 Reads

Ropinirole Augmentation for Depression: A Randomized Controlled Trial Pilot Study.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):78-81

Jerusalem Mental Health Center, Jerusalem, Israel.

Objective: Evidence both from animal and human studies suggests a role for dopaminergic pathways in the treatment of depression. Ropinirole, a selective agonist of dopamine D2/D3, is in use for the treatment of parkinsonism. Preliminary evidence suggests that such agonists might be useful as antidepressants. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000984DOI Listing
November 2018
15 Reads

Potential Explanations for Increasing Methylphenidate Use in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder in Germany From 2004 to 2013.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):39-45

Background: Despite a decreasing population of children and adolescents, the cumulative total amount of dispensed methylphenidate (MPH), the first-choice treatment of attention-deficit/hyperactivity disorder (ADHD) in this age group, has increased dramatically in Germany. We investigated potential reasons for this increase such as changes in the ADHD prevalence over time and other potential explanations including the cumulative amount of dispensed MPH per person.

Methods: Based on German claims data, we calculated standardized annual ADHD prevalence rates, proportions of ADHD cases treated with MPH and/or psychotherapy, and mean cumulative defined daily doses of ADHD drugs for 3- to 17-year-old children and adolescents from 2004 to 2013. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000980DOI Listing
November 2018
2 Reads

Gabapentin Abuse by Nasal Insufflation: A Case Report.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):89-91

Department of Psychiatry, Rutgers New Jersey Medical School, Behavioral Health Sciences, Newark, NJ Rutgers New Jersey Medical School, Newark, NJ VA New Jersey Healthcare System, East Orange, NJ.

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http://dx.doi.org/10.1097/JCP.0000000000000983DOI Listing
November 2018
5 Reads

Clozapine Addition Following Brain Surgery in Severe Primary Obsessive-Compulsive Disorder With Tardive Movement Disorder.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):86-87

Department of Physiology, Los Andes University Medical School, Mérida, Venezuela Department of Neurology, Los Andes University Medical School, érida, Venezuela University of Kentucky Mental Health, Research Center, Eastern State Hospital, Lexington, KY, Psychiatry and Neurosciences, Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain

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http://dx.doi.org/10.1097/JCP.0000000000000982DOI Listing
November 2018
7 Reads

Two Manic Episodes Related to a Levetiracetam-Based Treatment in a 34-Year-Old Female Patient: A Case Report.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):87-88

AP-HP GH Saint-Louis Lariboisière, F. Widal, Pôle de Psychiatrie et de Médecine Addictologique, 75475 Paris cedex 10, France AP-HP GH Saint-Louis Lariboisière, F. Widal, Pôle pré-bloc, Service de Pharmacie, 75475 Paris cedex 10, France AP-HP GH Saint-Louis Lariboisière, F. Widal, Pôle de Psychiatrie et de Médecine Addictologique, 75475 Paris cedex 10, France AP-HP GH Saint-Louis Lariboisière, F. Widal Pôle de Psychiatrie et de Médecine Addictologique 75475 Paris cedex 10 Department of Psychiatry Université Paris Descartes UMR-S 1144 Paris, F-75006 Department of Psychiatry Université Paris Diderot Sorbonne Paris Cité UMR-S 1144 Paris, F-75013 and Department of Psychiatry Inserm U1144, Paris F-75006, France.

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http://dx.doi.org/10.1097/JCP.0000000000000978DOI Listing
November 2018
9 Reads

Predicting Unsuccessful Clozapine Treatment After First Use in Adult Patients With Psychotic Disorders.

J Clin Psychopharmacol 2018 Dec;38(6):604-608

Yulius Mental Health, Dordrecht.

Purpose/background: Cessation of clozapine therapy and insufficient response may result in relapse of psychotic symptoms and in clinical admissions. However, discontinuation rates are high. Identifying patients at risk for unsuccessful clozapine use might enable clinicians to direct specific attention to them. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000977DOI Listing
December 2018
10 Reads

A Useful Example of Pharmaco-Electroencephalogram Science: Invited Commentary on Article by Dr Dias Alves.

Authors:
Max Fink

J Clin Psychopharmacol 2018 Dec;38(6):552-554

Affiliation: Professor of Psychiatry and Neurology Emeritus, Stony Brook University School of Medicine, Stony Brook, NY.

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http://dx.doi.org/10.1097/JCP.0000000000000974DOI Listing
December 2018
1 Read

The Role of Atomoxetine for Parkinson Disease-Related Executive Dysfunction: A Systematic Review.

J Clin Psychopharmacol 2018 Dec;38(6):627-631

Pharmacy Department, Durham Veterans Affairs Health Care System, Durham, NC.

Background: Atomoxetine selectively inhibits the reuptake of norepinephrine. Given the noradrenergic system's role in executive function, pharmacotherapy options that affect norepinephrine are of particular clinical interest in Parkinson disease-related executive dysfunction.

Objective: The aim of this study was to assess the efficacy and safety of atomoxetine for Parkinson disease-related executive dysfunction. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000963DOI Listing
December 2018
10 Reads

The Relationship Between Pregnancy Exposure to Antidepressant and Atypical Antipsychotic Medications and Placental Weight and Birth Weight Ratio: A Retrospective Cohort Study.

J Clin Psychopharmacol 2018 Dec;38(6):563-569

Division of Obstetrics & Gynaecology, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Crawley, Western Australia, Australia.

Background: Psychotropic medication use in pregnancy has been associated with altered fetal growth. The aim of this study was to investigate the relationship between placental weight and placental weight-to-birth weight (PBW) ratio, as a potential marker of placental efficiency, and medication use in a cohort of women with severe mental illness in pregnancy.

Methods: A retrospective database analysis was carried out on a cohort of pregnant women with severe mental illness (242 singleton pregnancies) and grouped according to their psychotropic medication use. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000964DOI Listing
December 2018
5 Reads

WITHDRAWN: Serum Non-High-Density Lipoprotein Cholesterol Is Negatively Correlated With the Severity of Depressive Disorder.

J Clin Psychopharmacol 2018 10 19. Epub 2018 Oct 19.

Institute of Mental Health, North China University of Science and Technology, Tangshan, China.

Ahead of Print article withdrawn by publisher. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000952DOI Listing
October 2018
13 Reads

Possible Interactions Between 5-HT2A Receptors and the Endocannabinoid System in Humans: Preliminary Evidence of Interactive Effects of Ayahuasca and Endocannabinoids in a Healthy Human Subject.

J Clin Psychopharmacol 2018 Dec;38(6):644-646

Departamento de Neurociências e Ciências do Comportamento Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (USP) Instituto Nacional de Ciência e Tecnologia-Medicina Translacional Ribeirão Preto, Brazil and ICEERS Foundation (International Center for Ethnobotanical Education, Research and Services) Barcelona, Spain Departamento de Neurociências e Ciências do Comportamento Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (USP) and Instituto Nacional de Ciência e Tecnologia-Medicina Translacional Ribeirão Preto, Brazil Departamento de Neurociências e Ciências do Comportamento Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (USP) Ribeirão Preto, Brazil Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo (USP) Ribeirão Preto, Brazil Instituto Nacional de Ciência e Tecnologia-Medicina Translacional Faculdade de Ciências Farmacêuticasde Ribeirão Pretoand Departamento de Química Universidade de São Paulo (USP) Ribeirão Preto, Brazil. Faculdade de Ciências Farmacêuticas, Universidade de São Paulo (USP) São Paulo, Brazil Departamento de Neurociências e Ciências do Comportamento Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (USP) and Instituto Nacional de Ciência e Tecnologia-Medicina Translacional Ribeirão Preto, Brazil.

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December 2018
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Treatment Continuation of 3 Second-Generation Antipsychotic Long-Acting Injections, and Oral Paliperidone in Patients With Schizophrenia for 2 Years.

J Clin Psychopharmacol 2018 Dec;38(6):649-650

Department of Psychiatry, Suzuki Clinic Tokyo, Japan Department of Psychiatry, Fukui Kinen Hospital, Kanagawa, Japan Department of Psychiatry, Shakomae Kokorono Clinic, Tokyo, Japan Department of Psychiatry, Fukui Kinen Hospital, Kanagawa, Japan.

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http://dx.doi.org/10.1097/JCP.0000000000000976DOI Listing
December 2018
3 Reads

Myocarditis During Treatment With Clozapine in 2 Adolescent Cases.

J Clin Psychopharmacol 2018 Dec;38(6):639-640

Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Department of Pediatric Cardiology, University Heart Center Hamburg, Hamburg, Germany Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1097/JCP.0000000000000967DOI Listing
December 2018
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3.243 Impact Factor

Attitudes Concerning Antipsychotic Depot Medication in the German General Population: A Representative Telephone Survey.

J Clin Psychopharmacol 2018 Dec;38(6):612-617

Department of Psychiatry, Social Psychiatry and Psychotherapy, Centre for Mental Health, Medical University Hannover (MHH), Hannover, Germany.

Background: Treatment of schizophrenia with depot medication has advantages compared with oral medication, and among these include an improved compliance. Despite such advantages, prescription rates in many European countries are lower than 20%. The aim of this survey was to study the attitudes toward depot medication among the German general population. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000957DOI Listing
December 2018
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Is There Always a Right or Wrong?: Comments on the FDA Warnings About Triptans and the Serotonin Syndrome.

J Clin Psychopharmacol 2018 Dec;38(6):545-546

136 Harrison Avenue, Tufts University School of Medicine, Boston, MA.

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December 2018
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Methylenedioxymethamphetamine (MDMA) in Psychiatry: Pros, Cons, and Suggestions.

J Clin Psychopharmacol 2018 Dec;38(6):632-638

Centre for Addiction Research, School of Population Health, University of Auckland, Auckland, New Zealand.

Background: For a number of mental health disorders, including posttraumatic stress disorders (PTSD), there are not many available treatment options. Recently, there has been renewed interest in the potential of methylenedioxymethamphetamine (MDMA) to restore function for patients with these disorders. The primary hypothesis is that MDMA, via prosocial effects, increases the ability of patients to address the underlying psychopathology of the disorder. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000962DOI Listing
December 2018
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Statistics Commentary Series: Commentary No. 29: Network Meta-Analysis.

Authors:
David L Streiner

J Clin Psychopharmacol 2018 Dec;38(6):549-551

From the Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton; and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000000971DOI Listing
December 2018
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Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients.

J Clin Psychopharmacol 2018 Dec;38(6):570-576

Center for Psychopharmacology, Diakonhjemmet Hospital.

Purpose: Olanzapine is a commonly prescribed antipsychotic available as oral and long-acting injectable (LAI) formulations. Data are lacking on the use and safety of olanzapine-LAI in older patients. The aim of this study was to investigate the effect of increasing age on olanzapine exposure during oral versus LAI administration in a real-life setting. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000961DOI Listing
December 2018

In Memoriam: Bernard J. Carroll, MD, PhD.

Authors:
Richard I Shader

J Clin Psychopharmacol 2018 Dec;38(6):547-548

From Tufts University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1097/JCP.0000000000000975DOI Listing
December 2018