27,680,764 results match your criteria Journal of clinical oncology : official journal of the American Society of Clinical Oncology[Journal]

  • Page 1 of 553616

Strange Bedfellows: Native American Tribes, Big Pharma, and the Legitimacy of Their Alliance.

Authors:
Daniel C Kennedy

Duke Law J 2019 Apr;68(7):1433-68

Lost in the cacophony surrounding the debate about high drug prices is the fundamental principle that pharmaceutical innovation will not occur without the prospect of outsized returns enabled through market exclusivity. Biopharmaceutical patents are currently under siege, subject to challenge both in inter partes review ("IPR") proceedings and in Hatch-Waxman actions. These twin assaults threaten to eliminate the incentives necessary for biotechnological innovation--particularly for discoveries made upstream in the innovation pipeline--thus imperiling the development of new drug therapies. Read More

View Article

Download full-text PDF

Source

Effect of artificial urinary sphincter implantation on erectile function and sexual satisfaction.

Andrologia 2019 Apr 17:e13295. Epub 2019 Apr 17.

Deparment of Urology, University of Health Sciences, Haydarpasa Numune Research & Training Hospital, Istanbul, Turkey.

Artificial urinary sphincter (AUS) implantation is the gold standard treatment in total stress urinary incontinence (SIU). Our aim is to evaluate the effect of AUS implantation on erectile function and sexual satisfaction (SS). Fourteen patients aged 58-73 years (mean: 66. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13295DOI Listing

Retroperitoneal high ligation versus subinguinal varicocelectomy: Effectiveness of two different varicocelectomy techniques on the treatment of painful varicocele.

Andrologia 2019 Apr 17:e13293. Epub 2019 Apr 17.

Department of Urology, Faculty of Medicine, Hitit University, Çorum, Turkey.

In the present study, we compared the retroperitoneal high ligation with subinguinal varicocelectomy on the treatment of painful varicocele. A total of 90 patients who underwent retroperitoneal high ligation (n = 45) and subinguinal varicocelectomy (n = 45) for painful varicocele were included in this prospective study. Varicocele in all patients was diagnosed with by physical examination and coloured Doppler ultrasonography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13293DOI Listing

Disordered APC/C-mediated cell cycle progression and IGF1/PI3K/AKT signalling are the potential basis of Sertoli cell-only syndrome.

Andrologia 2019 Apr 17:e13288. Epub 2019 Apr 17.

Institute of Reproductive & Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.

The cause of Sertoli cell-only syndrome (SCOS), a condition in which only Sertoli cells line the seminiferous tubules in the testis, is unknown. Three microarray data sets were downloaded from public databases and were used to compare SCOS and control group. A total of 291 genes differentially expressed (Log |FC| ≥ 1 and adjusted p value < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13288DOI Listing

The effects of acrylamide and Vitamin E administration during pregnancy on adult rats testis.

Andrologia 2019 Apr 17:e13292. Epub 2019 Apr 17.

Faculty of Medicine, Department of Biostatistics, Inonu University, Malatya, Turkey.

Thirty rats, with confirmed pregnancies by vaginal smear, were divided into five groups, each including six rats, as the Control, Corn Oil, Vitamin E, Acrylamide, Vitamin E + Acrylamide groups. The births were monitored on the 21st day to select the male rats, and the selected male rats were decapitated at the end of the 8th week. Oxidant-antioxidant parameters, serum hormone levels and histopathological examinations were performed on testis tissues of the rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13292DOI Listing

Case of paediatric steroid-induced glaucoma showing extremely fast progression with deformation of lamina cribrosa.

Clin Exp Optom 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cxo.12908DOI Listing

Young carers in England: Findings from the 2018 BBC survey on the prevalence and nature of caring among young people.

Child Care Health Dev 2019 Apr 17. Epub 2019 Apr 17.

University of Sussex, UK.

Background: Many young people are involved in caring for parents, siblings, or other relatives who have an illness or disability. The aim of this study was to estimate the prevalence of caring by young people in England.

Method: A national survey of 925 English young people was conducted using the 18-item survey version of the Multidimensional Assessment of Caring Activities Checklist for Young Carers (MACA-YC18). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cch.12674DOI Listing

Digital vs face-to-face information provision in patient counselling for prenatal screening: a noninferiority randomized controlled trial.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

VU University Amsterdam, Athena Institute for Trans-Disciplinary Research, the Netherlands.

Objective: To evaluate face-to-face information provision in patient counselling for prenatal screening compared to two forms of digital information provision, namely non-interactive instructional video or interactive video.

Method: We performed a prospective, non-inferiority, cluster-randomized controlled trial comparing face-to-face (usual care) to two forms of digital information provision (intervention) in counselling for prenatal screening. This study was performed in the Amsterdam UMC, the Netherlands in 2017, and included women in the first trimester of pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pd.5463DOI Listing

Different response of bacteria, archaea and fungi to process parameters in nine full-scale anaerobic digesters.

Microb Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Microbiology and Biotechnology, Ulm University, Ulm, Germany.

Biogas production is a biotechnological process realized by complex bacterial, archaeal and likely fungal communities. Their composition was assessed in nine full-scale biogas plants with distinctly differing feedstock input and process parameters. This study investigated the actually active microbial community members by using a comprehensive sequencing approach based on ribosomal 16S and 28S rRNA fragments. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-7915.13
Publisher Site
http://dx.doi.org/10.1111/1751-7915.13409DOI Listing
April 2019
1 Read

Gaming National Emergency Access Target performance using Emergency Treatment Performance definitions and emergency department short stay units.

Emerg Med Australas 2019 Apr 17. Epub 2019 Apr 17.

Sax Institute, Sydney, New South Wales, Australia.

Objective: To evaluate potential gaming of the 4 h ED length of stay metric known as the National Emergency Access Target (NEAT) in Australia and Emergency Treatment Performance (ETP) in New South Wales (NSW).

Methods: Descriptive statistical analysis was used to recalculate and compare the scores for NEAT and the NSW ETP using variations in the definitions of their measurement on 32 184 presentations during 2016. A computer simulation using a discrete event model illustrated the effect of the use of ED short stay beds on the ETP scores. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1742-6723.13295DOI Listing

[Maternal Emergencies: Methodically qualified - Conclusive Treatment].

Z Geburtshilfe Neonatol 2019 Apr 17;223(2):73-84. Epub 2019 Apr 17.

Institut für Rettungs- und Notfallmedizin, Universitätsklinikum Schleswig Holstein.

Maternal emergencies can significantly affect the outcome of pregnancy and childbirth. Since obstetrical emergencies may happen at any time during pregnancy an emergency transport to a hospital nearby may not always be possible. So, obstetrical emergency-management may already become mandatory in a prehospital setting. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0762-1024
Publisher Site
http://dx.doi.org/10.1055/a-0762-1024DOI Listing
April 2019
1 Read

„Ganz der Vater“?

Authors:
Dominique Singer

Z Geburtshilfe Neonatol 2019 Apr 17;223(2):65. Epub 2019 Apr 17.

Sektion Neonatologie und Pädiatrische Intensivmedizin, Zentrum für Geburtshilfe, Kinder- und Jugendmedizin, Universitätsklinikum Eppendorf (UKE).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0857-3222DOI Listing

[The Stepwise Care of Very Low Birth Weight Infants in Germany and Internationally].

Z Geburtshilfe Neonatol 2019 Apr 17. Epub 2019 Apr 17.

Kompetenz-Centrum Qualitätssicherung / Qualitätsmanagement, MDK Baden-Württemberg, Stuttgart.

Objective: In Germany the care of newborn infants is regulated by directives of the Federal Joint Committee. Assignment to the four levels of care, with level 1 being the highest level, is based on maternal risk factors, maternal and fetal diseases, birth weight and gestational age. This article compares birth weight and gestational age limits used in Germany with international regulations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0868-2513DOI Listing

How to Check the Reliability of Artificial Intelligence Solutions-Ensuring Client Expectations are Met.

Authors:
Jon Patrick

Appl Clin Inform 2019 Mar 17;10(2):269-271. Epub 2019 Apr 17.

Health Language Analytics Global, Eveleigh, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1685220DOI Listing

Evaluating the Effect of Monitoring through Telephone (Tele-Monitoring) on Self-Care Behaviors and Readmission of Patients with Heart Failure after Discharge.

Appl Clin Inform 2019 Mar 17;10(2):261-268. Epub 2019 Apr 17.

Department of Nursing & Emergency Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background:  Heart failure is one of the serious cardiovascular diseases, which poses a global pandemic and places a heavy burden on health care systems worldwide. The incidence of this disease in Iran is higher than in other Asian countries. To reduce patients' complications, readmission rates, and health care expenditures, it is necessary to design interventions, which are culturally appropriate and based on community needs. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685167
Publisher Site
http://dx.doi.org/10.1055/s-0039-1685167DOI Listing
March 2019
2 Reads

The combination of 13N-ammonia and 18F-FDG PET/CT in the identification of metabolic phenotype of primary human brain tumors.

Nuklearmedizin 2019 Apr 17. Epub 2019 Apr 17.

Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-Sen University.

Aim: This pilot study made a preliminary attempt to distinguish different metabolic phenotypes of primary human brain tumors with dual tracer N-ammonia and F-FDG.

Methods: 74 patients were included in this study including 12 benign meningiomas (B-MEN), 4 malignant meningiomas (M-MEN), 15 low-grade gliomas (LGG), 32 high-grade gliomas (HGG) and 11 primary central nervous system lymphomas (PCNSL). All patients underwent N-ammonia and F-FDG PET imaging. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0835-5746
Publisher Site
http://dx.doi.org/10.1055/a-0835-5746DOI Listing
April 2019
1 Read

Underwater endoscopic mucosal resection for remaining early gastric cancer after endoscopic submucosal dissection.

Endoscopy 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0875-3429DOI Listing

Outcome of inter-hospital transfer of patients on extracorporeal membrane oxygenation in Switzerland.

Swiss Med Wkly 2019 Apr 17;149:w20054. Epub 2019 Apr 17.

Clinic for Cardiovascular Surgery, University Heart Centre, Zurich, Switzerland.

Aims Of The Study: An extracorporeal membrane oxygenation system (ECMO), as a bridge to either recovery, a ventricular assist device (VAD), or heart or lung transplantation, may be the only lifesaving option for critically ill patients suffering from refractory cardiac, respiratory or combined cardiopulmonary failure. As peripheral hospitals may not offer ECMO treatment, tertiary care centres provide specialised ECMO teams for on-site implantation and subsequent patient transfer on ECMO to the tertiary hospital. This study reports the results of the largest ECMO transportation programme in Switzerland and describes its feasibility and safety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4414/smw.2019.20054DOI Listing

Predictive error processing distinguishes between relevant and irrelevant errors after visuomotor learning.

J Vis 2019 Apr;19(4):18

Department of Psychology and Sport Science, Justus Liebig University Giessen, Giessen, Germany.

Error processing is an important aspect of learning. The detection and online correction of an error as well as error-based adaptation of subsequent movements enables humans to improve behavior. For this improvement, it is necessary to differentiate between relevant and irrelevant errors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/19.4.18DOI Listing

Back cover.

Authors:

Phys Chem Chem Phys 2019 Apr 17;21(16):8600. Epub 2019 Apr 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/C9CP90119ADOI Listing

Inside back cover.

Authors:

Phys Chem Chem Phys 2019 Apr 17;21(16):8599. Epub 2019 Apr 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/C9CP90118CDOI Listing

Contents list.

Authors:

Phys Chem Chem Phys 2019 Apr 17;21(16):8185-8196. Epub 2019 Apr 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/C9CP90117EDOI Listing

Inside front cover.

Authors:

Phys Chem Chem Phys 2019 Apr 17;21(16):8184. Epub 2019 Apr 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/C9CP90116GDOI Listing

Front cover.

Authors:

Phys Chem Chem Phys 2019 Apr 17;21(16):8183. Epub 2019 Apr 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/C9CP90115ADOI Listing

Association between neonatal serum bilirubin and childhood obesity in preterm infants.

Pediatr Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Background: Serum bilirubin levels are inversely associated with obesity in adults. We are interested in whether neonatal jaundice is associated with childhood obesity in preterm infants.

Methods: Data were obtained from the US Collaborative Perinatal Project. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41390-019-0399-3
Publisher Site
http://dx.doi.org/10.1038/s41390-019-0399-3DOI Listing
April 2019
2 Reads

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.

CRISPR-Cas base editor technology enables targeted nucleotide alterations and is being rapidly deployed for research and potential therapeutic applications. The most widely used base editors induce DNA cytosine (C) deamination with rat APOBEC1 (rAPOBEC1) enzyme, which is targeted by a linked Cas protein-guide RNA (gRNA) complex. Previous studies of cytosine base editor (CBE) specificity have identified off-target DNA edits in human cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1161-zDOI Listing
April 2019
1 Read

The Impact of Continuous Positive Airway Pressure upon Pleural Fluid Pressures during Thoracentesis.

Respiration 2019 Apr 17:1-5. Epub 2019 Apr 17.

University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.

Background: Excessive drop of pleural pressure (Ppl) during therapeutic thoracentesis may be related to adverse events and/or to repeated procedures due to incomplete drainage.

Objective: This was a pilot study of the impact of the application of continuous positive airway pressure (CPAP) at +5 cm H2O upon the Ppl profile during thoracentesis.

Methods: This was a prospective, controlled study of 49 consecutive adults who underwent thoracentesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496610DOI Listing
April 2019
1 Read

Effect of Postoperative Radiotherapy for Brain Metastases: An Analysis.

Oncol Res Treat 2019 Apr 17;42(5):253-259. Epub 2019 Apr 17.

Department of Radiation Oncology, University Hospital Münster, Münster, Germany.

Introduction: Brain metastases (BM) have a very poor prognosis, creating a demand for effective local therapies, such as radiotherapy (RT) and neurosurgery, the combination of which is debatable. The aim of the present study was to investigate prognostic factors and to develop treatment recommendations for patients with BM.

Material And Methods: A total of 84 patients treated between May 2011 and July 2016 were analyzed in a single-institution retrospective study. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/499323
Publisher Site
http://dx.doi.org/10.1159/000499323DOI Listing
April 2019
1 Read

Patient Attitude towards Videodermatoscopy for the Detection of Skin Cancer: A Cross-Sectional Study.

Oncol Res Treat 2019 Apr 17:1-6. Epub 2019 Apr 17.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany,

Background: Videodermatoscopy (VD) is a useful device for supporting dermatologists in the distinction between benign and malignant lesions. However, only few patients have access to VD in daily practice.

Objectives: To investigate patient attitudes towards VD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499630DOI Listing

Persistent leptin signalling in the arcuate nucleus impairs hypothalamic insulin signalling and glucose homeostasis in obese mice.

Neuroendocrinology 2019 Apr 16. Epub 2019 Apr 16.

Background: Obesity is associated with reduced physiological responses to leptin and insulin, leading to the concept of obesity-associated hormonal resistance.

Objectives: Here, we demonstrate that contrary to expectations, leptin signalling not only remains functional but is constantly activated in the arcuate nucleus of the hypothalamus (ARH) neurons of obese mice. This state of persistent response to endogenous leptin underpins the lack of response to exogenous leptin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500201DOI Listing

Clinical Experience of Immunotherapy Treatment: Efficacy and Toxicity Analysis of the Compassionate Use Program of Nivolumab in Patients with Advanced Squamous Cell Non-Small Cell Lung Cancer.

Oncol Res Treat 2019 Apr 17;42(5):243-254. Epub 2019 Apr 17.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.

Background: Anti-PD1 monoclonal antibody nivolumab is an approved therapy option for the treatment of advanced squamous cell non-small cell lung cancer (SQ-NSCLC) patients. Data outside clinical trials about therapy efficacy and safety in later therapy line treatments have rarely been described until now.

Methods: We performed a retrospective data analysis of patients who were enrolled into the nivolu-mab Compassionate Use Program (CUP) in Germany. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499321DOI Listing

Blood Chromogranin A is Not Effective as a Biomarker for Diagnosis or Management of Bronchopulmonary NET/NET.

Neuroendocrinology 2019 Apr 16. Epub 2019 Apr 16.

Background: Identification of circulating tumor markers for clinical management in bronchopulmonary (BP) neuroendocrine tumors/neoplasms (NET/NEN) is of considerable clinical interest. Chromogranin A (CgA), a "universal" NET biomarker, is considered controversial as a circulating biomarker of BPNEN.

Aim: Assess utility of CgA in the diagnosis and management of BPNEN in a multicentric study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500202DOI Listing

Inhibition of HSF1 enhances repressive molecular mechanisms on POMC promoter.

Neuroendocrinology 2019 Apr 16. Epub 2019 Apr 16.

Background: Cushing´s Disease (CD) is caused by adrenocorticotropic hormone (ACTH)- secreting pituitary tumours. They express high levels of heat shock protein (HSP) 90 and heat shock factor 1 (HSF1) in comparison to the normal tissue counterpart, indicating activated cellular stress.

Aims: (1) to correlate HSF1 expression with clinical features and hormonal/radiological findings of CD and (2) to investigate the effects of HSF1 inhibition as a target for CD treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500200DOI Listing

Intravitreal Ranibizumab Injection for the Treatment of Retinopathy of Prematurity.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: To evaluate the efficacy of a single injection of 0.3 mg of intravitreal ranibizumab for the treatment of retinopathy of prematurity.

Methods: We conducted this retrospective case series study in King Abdul Aziz Medical City, Riyadh, Saudi Arabia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500310DOI Listing
April 2019
1 Read

Phenotypic and Genotypic characterization of ESBLs, AmpC and Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli Isolates.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: Drug resistance among gram-negative bacteria is a worldwide challenge. Due to the importance of drug-resistant Klebsiella pneumoniae and Escherichia coli strains in hospital-acquired infections, we aimed to determine the phenotypic and genotypic characteristics of ESBLs, AmpC and Carbapenemase-producing isolates, obtained from hospitalized patients in Tehran and Ilam, Iran.

Materials And Methods: In total, 90 isolates of K. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500311DOI Listing

IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population.

Chemotherapy 2019 Apr 17:1-8. Epub 2019 Apr 17.

Department of Radiotherapy, Shaanxi Provincial Cancer Hospital Affiliated to Medical College, Xi'an Jiaotong University, Xi'an, China,

Background: Recent evidence suggested that IL1RN (interleukin-1 receptor antagonist) polymorphisms increased the susceptibility to cancers. The present study aimed to evaluate whether IL1RN was related to esophageal cancer susceptibility in a Northwest Han Chinese population.

Methods: The case-control study was conducted on 384 esophageal cancer patients and 499 healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496400DOI Listing

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury.

Am J Nephrol 2019 Apr 17;49(6):449-459. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Center for Kidney Diseases (VCKD) and Integrated Program for AKI Research (VIP-AKI), Nashville, Tennessee, USA.

Background: Acute kidney injury (AKI) survivors are at risk for chronic kidney disease, recurrent AKI, and cardiovascular disease. The transition from hospital to ambulatory care is an opportunity to reduce these sequelae by launching self-care plans through effective patient education. How well AKI survivors are informationally prepared to apply kidney-specific self-care is unknown. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/499862
Publisher Site
http://dx.doi.org/10.1159/000499862DOI Listing
April 2019
1 Read

Comparison of Place-versus-Pitch Mismatch between a Perimodiolar and Lateral Wall Cochlear Implant Electrode Array in Patients with Single-Sided Deafness and a Cochlear Implant.

Audiol Neurootol 2019 Apr 17;24(1):38-48. Epub 2019 Apr 17.

Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: In electric-acoustic pitch matching experiments in patients with single-sided deafness and a cochlear implant, the observed "mismatch" between perceived pitch and predicted pitch, based on the amended Greenwood frequency map, ranges from -1 to -2 octaves. It is unknown if and how this mismatch differs for perimodiolar versus lateral wall electrode arrays.

Objectives: We aimed to investigate if the type of electrode array design is of influence on the electric-acoustic pitch match. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499154DOI Listing

Fruit and Vegetable Treatment of Chronic Kidney Disease-Related Metabolic Acidosis Reduces Cardiovascular Risk Better than Sodium Bicarbonate.

Am J Nephrol 2019 Apr 17;49(6):438-448. Epub 2019 Apr 17.

Department of Internal Medicine, Texas A&M Health Sciences Center College of Medicine, Dallas, Texas, USA,

Background: Current guidelines recommend treatment of metabolic acidosis in chronic kidney disease (CKD) with sodium-based alkali. We tested the hypothesis that treatment with base-producing fruits and vegetables (F + V) better improves cardiovascular disease (CVD) risk indicators than oral sodium bicarbonate (NaHCO3).

Methods: We randomized 108 macroalbuminuric, matched, nondiabetic CKD patients with metabolic acidosis to F + V (n = 36) in amounts to reduce dietary acid by half, oral NaHCO3 (HCO3, n = 36) 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500042DOI Listing

Development and Validation of Molecular Assays for Limited Tissue Samples.

Acta Cytol 2019 Apr 17:1-8. Epub 2019 Apr 17.

Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

As the value of molecular testing of cancer specimens increases, the number of tests imposed on tumor specimens also increases, often in tension with the amount of tumor material available. To develop and validate molecular assays for limited specimens, there are specific concerns that must be addressed, including DNA quality, quantity, and abundance; the number of targets/ability to multiplex; and the analytical sensitivity and specificity of the assay itself. Ultimately, weighing these considerations during assay validation in the overall context of clinical utility and laboratory workflow is critical for delivering the highest level of personalized care to patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499109DOI Listing

Measuring Quality of Life in the Speaker with Dysarthria: Reliability and Validity of the European Portuguese Version of the QoL-DyS.

Folia Phoniatr Logop 2019 Apr 17:1-15. Epub 2019 Apr 17.

Dipartimento di Scienze Biomediche e Cliniche "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Background: The impact of acquired dysarthria on the person's life and social participation is well recognized and is the key to the process of rehabilitation. Evaluation of the effectiveness of an intervention that addresses this impact is a challenge for clinicians and researchers.

Objectives: The purpose of this study was to evaluate the validity and reliability of the European Portuguese version of the Quality of Life in the Speaker with Dysarthria (QoL-DyS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495564DOI Listing

Neurosurgeons' Armamentarium for the Management of Refractory Postherpetic Neuralgia: A Systematic Literature Review.

Stereotact Funct Neurosurg 2019 Apr 17;97(1):1-11. Epub 2019 Apr 17.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA.

Background/aims: Postherpetic neuralgia (PHN) can be refractory to both medical and minimally invasive treatments. Its complex pathophysiology explains the numerous neurosurgical procedures that have been implemented through the years. Our objective was to summarize all available neurosurgical strategies for the management of resistant PHN and evaluate their respective safety and efficacy outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499476DOI Listing

The Mealtime Assessment Scale (MAS): Part 2 - Preliminary Psychometric Analysis.

Folia Phoniatr Logop 2019 Apr 17:1-12. Epub 2019 Apr 17.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: The Mealtime Assessment Scale (MAS) was developed to assess swallowing safety and efficacy during the meal. The study aims to perform a preliminary validation of MAS by investigating internal consistency, inter-rater agreement, concurrent and known-group validity, and responsiveness.

Methods: MAS was tested on 100 persons without dysphagia (group 1) and 100 persons with dysphagia (group 2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494136DOI Listing

The Effect of Gonadotropin-Releasing Hormone Analogue on Final Adult Height in Children with Idiopathic Short Stature.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objective: Assess final adult height (FAH) in children with short stature treated with gonadotropin-releasing hormone analogue (GnRHa).

Methods: All patients with idiopathic short stature (ISS) with normally timed puberty and a Tanner stage between 2-3, who achieved their final adult height (FAH) between 2005 and 2015, were included in this clinical historical cohort study. Height gain, FAH and, mid-parental height of 28 children with ISS who received GnRHa treatment for 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499929DOI Listing
April 2019
1 Read

Staphylococcus aureus and Host Immunity in Recurrent Furunculosis.

Dermatology 2019 Apr 17:1-11. Epub 2019 Apr 17.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The most frequent S. aureus infections include impetigo, folliculitis, furuncles, furunculosis, abscesses, hidradenitis suppurativa, and mastitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499184DOI Listing

De novo Cardiac Valve Calcification after Hemodialysis in End-Stage Renal Disease Patients Predicts Future Cardiovascular Events: A Longitudinal Cohort Study.

Cardiorenal Med 2019 Apr 17;9(4):229-239. Epub 2019 Apr 17.

Renal Division, Department of Internal Medicine, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Background: Cardiac valve calcification (CVC) in maintenance hemodialysis patients is associated with adverse cardiovascular outcomes. However, whether de novo CVC in incident hemodialysis patients predicts future cardiovascular events is unknown.

Methods: This study included 174 patients newly receiving hemodialysis without CVC as reflected by echocardiography between January 2005 and December 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494701DOI Listing

Sense of Effort and Articulatory Contact Pressure Associated with Talking by Individuals Using Tracheoesophageal Speech.

Authors:
Jeff Searl

Folia Phoniatr Logop 2019 Apr 17:1-10. Epub 2019 Apr 17.

Hearing and Speech Department, University of Kansas Medical Center, Kansas City, Kansas, USA,

Background/aims: The aims of this study were (1) to determine locations of increased effort in the body when talking using tracheoesophageal speech (TES); (2) to compare talking effort for participants using TES and those using laryngeal speech; (3) to compare tongue-palate contact pressure during talking for TES and laryngeal speech; and (4) to assess the relationship between talking effort and articulatory contact pressure (ACP).

Methods: This cohort comparison study included 16 individuals using TES and 10 using laryngeal speech. Participants rated talking effort on a visual analog scale and then rated effort in the lungs, throat, oral cavity, brain (cognitive) and arm/shoulder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496794DOI Listing

Ultrasound-Guided Continuous Femoral Nerve Block with Dexmedetomidine Combined with Low Concentrations of Ropivacaine for Postoperative Analgesia in Elderly Knee Arthroplasty.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: This study aims to investigate the clinical effect of dexmedetomidine (DEX) combined with low concentrations of ropivacaine in ultrasound-guided continuous femoral nerve block for postoperative analgesia in elderly patients with total knee arthroplasty (TKA).

Materials And Methods: Patients were divided into three groups: group C, group D1 and group D2. For postoperative analgesia, patients in group C were given 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500261DOI Listing

NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

determined. Liver disease severity in patients with cirrhosis was established by Child-Pugh class, MELD score and presence/absence of ascites. Results: Plasma levels of NT-proBNP were significantly higher in cirrhotic patients than in the healthy subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499930DOI Listing
  • Page 1 of 553616