27,690,305 results match your criteria Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society[Journal]

  • Page 1 of 553807

Limberg flap reconstruction for sacrococcygeal pilonidal sinus disease with and without acute abscess: Our experience and a review of the literature.

Arch Plast Surg 2019 Apr 20. Epub 2019 Apr 20.

Long Island Plastic Surgical Group, Garden City, NY, USA.

Background: The efficacy of Limberg flap reconstruction for pilonidal sinus with acute abscess remains unclear. This study aimed to compare outcomes after Limberg flap reconstruction for pilonidal sinus disease with and without acute abscess. A secondary objective was to perform a review of the literature on the topic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5999/aps.2018.01312DOI Listing

Late avulsion of a free flap in a patient with severe psychiatric illness: Establishing a successful salvage strategy.

Arch Plast Surg 2019 Apr 20. Epub 2019 Apr 20.

Department of Plastic, Reconstructive and Hand Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Post-traumatic defects of the distal third of the leg often require skipping a few steps of the well-established reconstructive ladder, due to the limited local reliable reconstructive options. In rare cases, the reconstructive plan and flap choice may encounter challenges when the patient has psychiatric illness affecting compliance with postoperative care. We describe a case of a patient with severe intellectual disability and an open fracture of the distal lower limb. Read More

View Article

Download full-text PDF

Source
http://www.e-aps.org/journal/view.php?doi=10.5999/aps.2018.0
Publisher Site
http://dx.doi.org/10.5999/aps.2018.01039DOI Listing

Management of severe hidradenitis suppurativa with biologic therapy and wide excision.

Arch Plast Surg 2019 Apr 20. Epub 2019 Apr 20.

National Skin Centre, Singapore.

Hidradenitis suppurativa (HS) is a chronic inflammatory follicular occlusive disease that involves the intertriginous areas. Treatment methods include conventional topical and systemic medication, radiotherapy, biologic agents, and surgical excision. Of late, there has been an increased focus on the use of biologic agents in patients with moderate to severe HS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5999/aps.2018.00339DOI Listing

Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress.

Biomol Ther (Seoul) 2019 Apr 19. Epub 2019 Apr 19.

Departments of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea.

As the elderly population is increasing, Alzheimer’s disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials have been conducted and have failed, the development of new theraphies for AD with fewer adverse effects remains a challenge. In this study, we examined the effects of Theracurmin on cognitive decline using 5XFAD mice, an AD mouse model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4062/biomolther.2019.046DOI Listing

Flavonoids: Broad Spectrum Agents on Chronic Inflammatio.

Biomol Ther (Seoul) 2019 Apr 19. Epub 2019 Apr 19.

College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.

Flavonoids are major plant constituents with numerous biological/pharmacological actions both in vitro and in vivo. Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory genes such as cyclooxygenase-2/inducible nitric oxide synthase and many cytokines/chemokines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4062/biomolther.2019.034DOI Listing

Disseminated Trichosporon asahii infection in a combined liver-kidney transplant recipient successfully treated with voriconazole.

Immun Inflamm Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Infectious Disease, Medanta The Medicity, Gurgaon, Haryana, India.

Introduction: Trichosporon asahii is an emerging cause of systemic fungal infection in an immunocompromised host. Several life threatening disseminated T. asahii infection in single solid organ (liver or kidney) transplant recipients, in neutropenic and hematological malignancy patients have been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/iid3.250DOI Listing

Clinical analysis of EGFR-positive non-small cell lung cancer patients treated with first-line afatinib: A Nagano Lung Cancer Research Group.

Thorac Cancer 2019 Apr 20. Epub 2019 Apr 20.

Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto City, Japan.

Background: In the LUX-Lung 3 and LUX-Lung 6 trials, afatinib improved overall survival in previously untreated patients with EGFR 19del mutated non-small cell lung cancer (NSCLC) compared to chemotherapy. The appropriate management of adverse events and dose reduction of afatinib are important for EGFR-positive NSCLC patients. We conducted a retrospective and observational study of patients treated with first-line afatinib for EGFR-positive NSCLC in Nagano prefecture, Japan, focusing on efficacy and toxicities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1759-7714.13047DOI Listing

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1.

FEBS Open Bio 2019 Apr 1. Epub 2019 Apr 1.

Department of Biomedical Experimental and Clinical Sciences 'Mario Serio', University of Florence, Italy.

Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or management of osteoporosis. Osteocytes are the main regulators of bone remodelling. For the first time, we demonstrate here that blueberry juice (BJ), obtained from Vaccinium myrtillus, rich in polyphenols, shows antioxidant and antiosteoclastogenic properties in MLO-Y4 osteocytes. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/2211-5463.12
Publisher Site
http://dx.doi.org/10.1002/2211-5463.12634DOI Listing
April 2019
1 Read

Clomiphene citrate and neural tube defects: a meta-analysis of controlled observational studies.

BJOG 2019 Apr 21. Epub 2019 Apr 21.

Service Hospitalo-Universitaire de Pharmaco-Toxicologie, Hospices Civils de Lyon, France.

Background: At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15800DOI Listing

Artificial Intelligence (AI) and Pharmacometrics: Time to Embrace, Capitalize and Advance?

CPT Pharmacometrics Syst Pharmacol 2019 Apr 21. Epub 2019 Apr 21.

Clinical Pharmacology, GlaxoSmithKline, Collegeville, PA.

Artificial intelligence (AI) has been described as the machine for the fourth industrial revolution. Without exception, AI is predicted to change the face of every industry. In the field of drug development, AI is employed to enhance efficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/psp4.12418DOI Listing

Bactericidal and cytotoxic activity of a diarylheptanoid (etlingerin) isolated from a ginger (Etlingera pubescens) endemic to Borneo.

J Appl Microbiol 2019 Apr 21. Epub 2019 Apr 21.

School of Science, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.

Aims: The aim of this study was to investigate the antimicrobial activities of Etlingera pubescens, and to isolate and identify the antimicrobial compound.

Methods And Results: The crude extracts of E. pubescens were obtained through methanol extraction, and evaluated for antimicrobial activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jam.14287DOI Listing

Innovative microscale workflow from fungi cultures to Cell Wall-Degrading Enzyme screening.

Microb Biotechnol 2019 Apr 20. Epub 2019 Apr 20.

EA 7394 - ICV - Institut Charles Viollette, Univ. Lille 1, ISA, INRA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000, Lille, France.

This study aimed at developing a complete miniaturized high-throughput screening workflow for the evaluation of the Cell Wall-Degrading Enzyme (CWDE) activities produced by any fungal strain directly cultivated on raw feedstock in a submerged manner. In this study, wheat straw was selected as model substrate as it represents an important carbon source but yet poorly valorised to yield high added value products. Fungi were grown in a microbioreactor in a high-throughput (HT) way to replace the fastidious shaking flask cultivations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1751-7915.13405DOI Listing

Are sleep studies necessary prior to adenotonsillectomy? a retrospective case controlled study of eighty-two children.

Clin Otolaryngol 2019 Apr 21. Epub 2019 Apr 21.

Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, S10 2TH, UK.

Overnight pulse oximetry is often used to determine severity of sleep apnoea and likelihood of post-operative complications with a view to planning whether high dependency care (HDU) might be required but may introduce delays and cost into the patient pathway. In 82 children without co morbidities, mild post-operative respiratory complications requiring repositioning or oxygen occurred in 15 (36.6%) in those with severely abnormal oximetry (SpO2 4% dip index > 10/hr and/or SpO2 nadir <80%) and 4 (9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/coa.13346DOI Listing

Longitudinal linguistic outcomes of toddlers with congenital single sided deafness - six with and twelve without cochlear implant and nineteen normal hearing peers.

Clin Otolaryngol 2019 Apr 21. Epub 2019 Apr 21.

Department of Neurosciences, Experimental ORL, KU Leuven - University of Leuven.

This longitudinal study is the first to assess linguistic and cognitive outcomes of children with cSSD implanted at a very young age. Despite the young age, these developing skills could be assessed by means of standardized test material and comparison to control groups. The toddlers of the SSD_CI group wear their device and perform largely in line with the NH control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/coa.13347DOI Listing

Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study.

BJOG 2019 Apr 21. Epub 2019 Apr 21.

Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Objective: To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.

Design: Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).

Settings: Rural New Hampshire, US. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15799DOI Listing

Changes in ventilation and perfusion following lower lobe Endoscopic Lung Volume Reduction (ELVR) with endobronchial valves in COPD: A Preliminary Report.

Clin Respir J 2019 Apr 21. Epub 2019 Apr 21.

Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia.

Background: We have previously reported significant improvements in ventilation and perfusion (VQ) and V/Q matching in the contralateral lung, especially the non targeted lower zone in patients with severe COPD following upper lobe ELVR with endobronchial valves. However, V/Q changes after lower lobe ELVR have not been described.

Methods: 7 patients with lower lobe heterogeneous emphysema underwent unilateral lower lobe ELVR at Macquarie University Hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/crj.13031DOI Listing

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Acta Physiol (Oxf) 2019 Apr 21:e13286. Epub 2019 Apr 21.

Department of Internal Medicine, Division of Endocrinology Division of Endocrinology Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany.

Aim: In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC). This concept predicts that uPA is an important factor for sodium retention and that inhibition of uPA might be protective in nephrotic syndrome.

Methods: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13286DOI Listing

MiR-204-5p: a novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma.

Cancer Sci 2019 Apr 21. Epub 2019 Apr 21.

Department of Molecular Genetics.

Xp11.2 translocation renal cell carcinoma (Xp11 tRCC) is a rare sporadic pediatric kidney cancer caused by constitutively active TFE3 fusion proteins. Tumors in patients with Xp11 tRCC tend to recur and undergo frequent metastasis, in part due to lack of methods available to detect early stage disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14026DOI Listing
April 2019
1 Read

Photodynamic inactivation to prevent and disrupt Staphylococcus aureus biofilm under different media conditions.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, X5804BYA, Río Cuarto, Córdoba, Argentina.

Objective: The goal of this work was investigate the photodynamic activity of 5,10,15,20-tetrakis[4-(3-N,N-dimethylaminopropoxy)phenyl]chlorin (TAPC) and zinc(II) 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine iodide (ZnPPc ) as photosensitizers to inactivate S. aureus biofilms and prevent their formations in different culture media.

Methods: We incubated S. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12477
Publisher Site
http://dx.doi.org/10.1111/phpp.12477DOI Listing
April 2019
4 Reads

Chronic epididymitis and leptin and their associations with semen characteristics in men with infertility.

Am J Reprod Immunol 2019 Apr 21:e13126. Epub 2019 Apr 21.

Department of Urology, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai (200001), China.

Objective: The aim of this study was to ascertain the associations between serum leptin levels and chronic epididymitis and semen parameters in patients with infertility.

Methods: 846 patients who were diagnosed as primary infertility were enrolled and divided into four groups. The general information, blood lipids, reproductive hormones and semen parameters were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aji.13126DOI Listing

Children lose confidence in their potential to "be scientists", but not in their capacity to "do science".

Dev Sci 2019 Apr 21:e12837. Epub 2019 Apr 21.

New York University, Department of Psychology, 6 Washington Place, rm. 302, New York, NY, 10003.

Over the course of middle childhood, children's interest and beliefs about their own capacities for success in science often decline. This pernicious decline is especially evident among underrepresented groups, including girls, members of some racial and ethnic minorities, and children from lower socioeconomic backgrounds. The present research (N=306, ages 6-11) found that while children lose interest and feelings of efficacy about their potential to "be scientists" across middle childhood, they maintain more robust interest and efficacy about "doing science. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/desc.12837DOI Listing

Burden of Neurodegenerative Diseases in the Eastern Mediterranean Region, 1990-2016: Findings from the Global Burden of Disease 2016 Study.

Eur J Neurol 2019 Apr 21. Epub 2019 Apr 21.

Department of Community Medicine, Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background And Purpose: The Eastern Mediterranean Region (EMR) is experiencing a demographic shift towards rapid ageing at a time of political unrest. We aimed to estimate the burden of neurodegenerative disorders, and its relationship with sociodemographic indicators (SDI) in the EMR countries from 1990 to 2016.

Methods: Using data from the Global Burden of Disease (GBD) 2016 study, we calculated country-specific trends for prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for Alzheimer's disease/other dementias and Parkinson's disease in the EMR during 1990-2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ene.13972DOI Listing

A Prediction Model of Sleep Disturbances Among Female Nurses by Using the BP-ANN.

J Nurs Manag 2019 Apr 21. Epub 2019 Apr 21.

Peking Union Medical College & Chinese Academy of Medical Sciences, Director of WHO Collaborating Center for Nursing Policy-Making and Quality Management.

Aim: To describe sleep disturbances and fatigue among female registered nurses (RNs) in Beijing, and to develop a prediction model for sleep disturbances.

Background: Chinese nurses are required to work rotating shifts on a weekly basis, which could negatively impact their sleep and well-being.

Method: A total of 647 RNs participated in this study. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jonm.12782
Publisher Site
http://dx.doi.org/10.1111/jonm.12782DOI Listing
April 2019
1 Read

Phosphorylated NUB1 distinguishes α-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy.

Brain Pathol 2019 Apr 21. Epub 2019 Apr 21.

Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan.

Posttranslational modifications by phosphorylation, ubiquitination, neddylation, and other pathways have emerged as major regulators of cellular functions. NEDD8 ultimate buster 1, NUB1, is an adaptor protein, which negatively regulates the levels of the ubiquitin-like protein NEDD8 as well as neddylated proteins through proteasomal degradation. We previously reported that NUB1 is highly involved in the pathogenesis of synucleinopathy including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12728DOI Listing

Spectroscopic observations on human pigmentation.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Al Sabah Hospital, Kuwait.

Background: The main chromophores of human skin are melanins and hemoglobins along with carotenoids, bilirubin and other compounds. In an effort to study the spectral signatures of skin melanin we measured absorption spectra in a variety of situations, including a method to show early signs of re-pigmentation in vitiligo.

Methods: To measure skin in vivo, the essential component was a "Bifurcated Optical Fiber" with one end connected to the light source and the second end connected to the spectrometer while the common end was placed on the skin. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12474
Publisher Site
http://dx.doi.org/10.1111/phpp.12474DOI Listing
April 2019
2 Reads

Long-term Outcome of Percutaneous Transhepatic Biliary Drainage for Biliary Strictures Following Pediatric Liver Transplantation.

Clin Transplant 2019 Apr 21:e13570. Epub 2019 Apr 21.

Department of Transplant Surgery, Jichi Medical University.

Background: We present a retrospective analysis of our experience with pediatric liver transplantation (LT), focusing on the long-term outcome of percutaneous transhepatic biliary drainage (PTBD) for post-transplant biliary strictures.

Methods: Fifty-three PTBDs were performed for 41 pediatric recipients with biliary strictures. The median ages at LT and PTBD were 1. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.13570
Publisher Site
http://dx.doi.org/10.1111/ctr.13570DOI Listing
April 2019
1 Read

Influence of implant neck and abutment characteristics on peri-implant tissue health and stability. Oral Reconstruction Foundation Consensus Report.

Clin Oral Implants Res 2019 Apr 21. Epub 2019 Apr 21.

Section of Graduate Periodontology, University Complutense, Madrid, Spain.

The aim of this consensus meeting was to assess the influence of implant neck and abutment characteristics on peri-implant tissue health and stability. Group and plenary discussions were based on two systematic reviews focusing on the effect of titanium implants with different collar designs/ surface modifications and the abutment material on the stability of marginal bone levels (MBL's), peri-implant health, and survival rates. The changes in MBL's were not influenced by the abutment material and were also similar at one- and two-piece implants after one year of loading. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/clr.13439DOI Listing

Trait structure and redundancy determine sensitivity to disturbance in marine fish communities.

Glob Chang Biol 2019 Apr 21. Epub 2019 Apr 21.

MARBEC, Université de Montpellier, CNRS, IFREMER, IRD, 34095, Montpellier Cedex, France.

'Functional' diversity is believed to influence ecosystem dynamics through links between organismal traits and ecosystem processes. Theory predicts that key traits and high trait redundancy - large species richness and abundance supporting the same traits - can buffer communities against environmental disturbances. While experiments and data from simple ecological systems lend support, large-scale evidence from diverse, natural systems under major disturbance is lacking. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/gcb.14662
Publisher Site
http://dx.doi.org/10.1111/gcb.14662DOI Listing
April 2019
1 Read

The timeline development of female canine germ cells.

Reprod Domest Anim 2019 Apr 21. Epub 2019 Apr 21.

Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil.

During the sex differentiation, the primordial germ cells (PGCs) pass through a differentiation, becoming spermatogonial cells in males and oocytes in females. In this phase, there are difference in gene expression and differentiation potency between males and females. Specific cells markers has been essential in the PGCs meiosis beginning and become oocyte cells. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/rda.13444
Publisher Site
http://dx.doi.org/10.1111/rda.13444DOI Listing
April 2019
1 Read

Effect of Enamel matrix derivative-liquid in combination with a natural bone mineral on new bone formation in a rabbit GBR model.

Clin Oral Implants Res 2019 Apr 21. Epub 2019 Apr 21.

Department of Periodontology, University of Bern, Bern, Switzerland.

Objectives: Recently, a new liquid carrier system for enamel matrix derivate (EMD-liquid) was developed with better physico-chemical properties for improved adsorption of EMD to biomaterial surfaces. The aim of the present study was to investigate the bone regenerative potential of EMD-liquid in combination with a natural bone mineral (NBM) in vivo.

Methods: Four 6-mm defects were created in the calvaria of 6 New Zealand white rabbits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/clr.13440DOI Listing

Mast cells-induced immunopathology in recurrent pregnancy losses.

Am J Reprod Immunol 2019 Apr 21:e13128. Epub 2019 Apr 21.

Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061.

Problem: Mast cells (MC) have been known to play an important role in inflammation and angiogenesis by secreting numerous mediators, such as proteases, gelatinases and proteoglycans. Three different MC subtypes were found in the endometrial layers of the uterus. In this study, we aim to investigate the role of endometrial MCs in recurrent pregnancy losses (RPL). Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.13128
Publisher Site
http://dx.doi.org/10.1111/aji.13128DOI Listing
April 2019
1 Read

An Old Man's Love.

Authors:
Siu Fai Li

Acad Emerg Med 2019 Apr 21. Epub 2019 Apr 21.

Dept. of Emergency Medicine, Jacobi Medical Center, 1400 Pelham Parkway S., Bronx, NY, 10461.

He was just another old man in a busy Emergency Department during my clinical attending shift. An ambulance brought him in after he fell in the grocery store. My senior resident Carlo and I were called to see him because he was struggling with a C-collar that he didn't need. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acem.13771DOI Listing

Expression and biological functions of the CCL5-CCR5 axis in oral lichen planus.

Exp Dermatol 2019 Apr 21. Epub 2019 Apr 21.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder with T cell-mediated immunological pathogenesis. C-C motif chemokine ligand 5 (CCL5) and its receptor C-C motif chemokine receptor 5 (CCR5) play important roles in the activation and recruitment of T cells. This study sought to explore the expression and biological functions of the CCL5-CCR5 axis in OLP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13946DOI Listing

Carbon dynamics, net primary productivity (NPP) and human appropriated NPP (HANPP) across a forest-cocoa farm landscape in West Africa.

Glob Chang Biol 2019 Apr 21. Epub 2019 Apr 21.

Environmental Change Institute, School of Geography and the Environment, University of Oxford, Oxford, UK.

Terrestrial net primary productivity (NPP) is an important metric of ecosystem functioning; however, there is little empirical data on the NPP of human-modified ecosystems, particularly smallholder, perennial crops like cocoa (Theobroma cacao), which are extensive across the tropics. Human appropriated NPP (HANPP) is a measure of the proportion of a natural system's NPP that has either been reduced through land-use change or harvested directly and, previously, has been calculated to estimate the scale of the human impact on the biosphere. Additionally, human-modification can create shifts in NPP allocation and decomposition, with concomitant impacts on the carbon cycle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/gcb.14661DOI Listing

MaizeNet: A co-functional network for network-assisted systems genetics in Zea mays.

Plant J 2019 Apr 21. Epub 2019 Apr 21.

Department of Biotechnology, College of Life Sciences and Biotechnology, Yonsei University, Seoul, 03722, Korea.

Maize (Zea mays) has multiple uses in human food, animal fodder, starch and sweetener production, and as a biofuel, and is accordingly the most extensively cultivated cereal worldwide. To enhance maize production, genetic factors underlying important agricultural traits, including stress tolerance and flowering, have been explored through forward and reverse genetics approaches. Co-functional gene networks are systems biology resources useful in identifying trait-associated genes in plants by prioritizing candidate genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tpj.14341DOI Listing

Organic or conventional dairy farming in northern Spain: impacts on cow reproductive performance.

Reprod Domest Anim 2019 Apr 21. Epub 2019 Apr 21.

Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002, Lugo, Spain.

Organic farming has traditionally given preference to indigenous breeds that are well adapted to local conditions; however, current trends towards increased yields may produce less robust animals with potentially low fertility. The Holstein-Friesian breed dominates dairy sector, although there is a general concern that these cows may not be well adapted to organic systems. This study aims to evaluate the reproductive performance of organic dairy herds in northern Spain, by comparing organically-reared Holstein-Friesian with their counterparts reared on conventional farms and also with other organically reared breeds and crosses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/rda.13446DOI Listing

Novel Oral Lichen Planus Symptom Severity Measure for assessing patients' daily symptom experience.

Oral Dis 2019 Apr 21. Epub 2019 Apr 21.

AFYX Therapeutics, formerly known as Dermtreat, 2300, Copenhagen S, Denmark.

Objective: A novel Oral Lichen Planus Symptom Severity Measure was developed as a clinical outcome assessment of the daily symptom experience of patients with oral lichen planus.

Methods: A literature review and expert input were followed by open-ended concept elicitation interviews with 17 adults with oral lichen planus in the US and Ireland. Item content was generated and the interviews continued until input saturation was reached. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/odi.13109DOI Listing

Corticosteroids and Methotrexate as Adjuvants to Costimulation Blockade in Nonhuman Primate Renal Transplantation.

Clin Transplant 2019 Apr 21:e13568. Epub 2019 Apr 21.

Emory Transplant Center, Emory University, Atlanta, GA.

Belatacept, the CD28-B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates of early rejection, prompting a search for agents to pair with belatacept. Methotrexate (MTX) is an antimetabolite that has been found to be complimentary with abatacept, a lower affinity CD28-B7-specific analogue of belatacept, in the treatment of rheumatoid arthritis (RA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.13568DOI Listing

Oral premalignant lesions of smokers and non-smokers show similar carcinogenic pathways and outcomes. A clinicopathological and molecular comparative analysis.

J Oral Pathol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Pathology, Hospital Clínic, IDIBAPS, University of Barcelona, Spain.

Background: Oral premalignant lesions (OPML) are frequently extensive and multifocal leading high morbidity for patients. Although oral squamous carcinoma (OSCC) in non-smoker patients is increasing, little is known about OPML and the carcinogenesis process in these patients. The aims of the study were to insight and compare the clinicopathological and molecular characteristics of OPML of non-smoker and smoker patients from which one or multiple OSCC have developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jop.12864DOI Listing

Adherence to Optical Safety Guidelines for Laser-Assisted Hair Removal.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: In recent years, there was a rise in ocular injuries secondary to cosmetic laser-assisted hair removal.

Purpose: To assess the level of adherence to optical safety guidelines during laser-assisted hair removal performed by nurses or physicians in private practice.

Methods: A cross-sectional study was conducted at thirty-one private laser-assisted hair removal clinics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/phpp.12473DOI Listing

Factors Predicting Kidney Delayed Graft Function Among Recipients of Simultaneous Liver-Kidney Transplantation: Single Center Experience.

Clin Transplant 2019 Apr 21:e13569. Epub 2019 Apr 21.

Division of Transplantation and Hepatobiliary Surgery, University of Florida, FL, USA.

Background: Kidney delayed graft function (kDGF) remains a challenging problem following simultaneous liver and kidney transplantation (SLKT) with a reported incidence up to 40%. Given the scarcity of renal allografts, it is crucial to minimize the development of kDGF among SLKT recipients to improve patient and graft outcomes. We sought to assess the role of preoperative recipient and donor/graft factors on developing kDGF among recipients of SLKT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.13569DOI Listing

Time-dependent functional, morphological, and molecular changes in diabetic bladder dysfunction in streptozotocin-induced diabetic mice.

Neurourol Urodyn 2019 Apr 20. Epub 2019 Apr 20.

Department of pharmacology of Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Aim: Diabetic bladder dysfunction (DBD) is one of the most common and bothersome complications of diabetes mellitus (DM). This study aimed to investigate the functional, structural, and molecular changes of the bladder at 0, 3, 6, 9, and 12 weeks after DM induction by streptozotocin (STZ) in male C57BL/6 mice.

Methods: Male C57BL/6J mice were injected with STZ (130 mg/kg). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/nau.24008DOI Listing

An updated review of lipid-modifying therapy.

Authors:
Leon A Simons

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

UNSW Sydney, Sydney, NSW.

Statin drugs reduce low-density lipoprotein (LDL)-cholesterol (LDL-C) and cardiovascular risk. Ezetimibe may be used to supplement statin therapy, or used alone in cases of statin intolerance. Statin-associated side effects do occur, especially muscle symptoms and new onset diabetes, but they do not detract from the benefits of statin therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.50142DOI Listing

HIV Status Does Not Worsen Oral Health Outcomes.

J Clin Periodontol 2019 Apr 21. Epub 2019 Apr 21.

Department of Oral Biology, School of Dental Medicine, University of Pittsburgh.

Last January 31 , Journal of Clinical Periodontology just made available the report titled "A Retrospective Analysis of Dental Implant Survival in HIV Patients", which concluded that "implants placed in HIV-positive patients had similar survival rates as HIV-negative patients." These data support our hypothesis that infection by HIV does not lead to worse oral health outcomes, including worse periodontitis. We looked 6,092 individuals and selected all HIV-positive subjects (N=73) and matched them by age, sex, ethnicity, and smoking habits with 261 HIV-negative control subjects. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13116
Publisher Site
http://dx.doi.org/10.1111/jcpe.13116DOI Listing
April 2019
1 Read

The effects of pelvic floor muscle therapy on symptoms, voiding, and pevic floor muscle activity parameters in children with overactive bladder.

Neurourol Urodyn 2019 Apr 20. Epub 2019 Apr 20.

Division of Pediatric Urology, Private Dayanc Urology Center, Ankara, Turkey.

Introduction: Refractory overactive bladder (OAB) in children can be treated with second line modalities such as as biofeedback, transcutaneous electrical stimulation (TENS), and botulinum toxin. In this study, we aimed to investigate the efficacy of biofeedback-assisted pelvic floor muscle therapy (PFMT) on symptoms, bladder capacity, uroflowmetry, and pelvic floor muscle activity (PFMA) in children with resistant OAB or dysfunctional voiding (DV) with associated seconder bladder overactivity (DV/SBO).

Materials And Methods: A total of 24 children with resistant OAB were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/nau.24007DOI Listing

ABCA1 variants rs2230806 (R219K), rs4149313 (M8831I), and rs9282541 (R230C) are associated with susceptibility to coronary heart disease.

J Clin Lab Anal 2019 Apr 20:e22896. Epub 2019 Apr 20.

Department of Cardiovascular Disease, Changzhou No. 2 People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.

Background: To investigate the association between three single nucleotide polymorphisms (SNPs) of ABCA1 gene and susceptibility to coronary heart disease (CHD) in Chinese Han population.

Methods: A total of 484 CHD patients and 488 controls were included in the study. Three SNPs rs2230806 (R219K), rs4149313 (M8831I), and rs9282541 (R230C) in ABCA1 gene were genotyped by SNaPshot. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcla.22896DOI Listing

Testosterone deficiency in men with Type 2 diabetes: pathophysiology and treatment.

Diabet Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine Austin Health, University of Melbourne.

Epidemiological studies consistently demonstrate that lowered serum testosterone is not only common in men with established Type 2 diabetes, but also predicts future diabetic risks and increased mortality. Preclinical studies report plausible mechanisms by which low testosterone could mediate dysglycaemia. Exogenous testosterone treatment consistently reduces fat mass, increases muscle mass and improves insulin resistance in some studies, but the majority of currently available randomized controlled trials (RCTs) do not report a consistent glycaemic benefit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dme.13977DOI Listing

Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017.

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

Monash University, Melbourne, VIC.

Objectives: To assess variations by time of year and hospital in the uptake of influenza and pertussis vaccinations by pregnant women in Victoria; to identify factors associated with vaccination uptake.

Design, Setting: Retrospective analysis of data in the Victorian Perinatal Data Collection (VPDC), a population surveillance system for obstetric conditions, procedures, and pregnancy and birth outcomes.

Participants: Women whose pregnancies ended in a live or stillbirth during July 2015 - June 2017. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50125
Publisher Site
http://dx.doi.org/10.5694/mja2.50125DOI Listing

Parental punitive discipline and children's depressive symptoms: Associations with striatal volume.

Dev Psychobiol 2019 Apr 21. Epub 2019 Apr 21.

Teachers College, Columbia University, New York, New York.

Although parental harshness has been consistently linked with increased depressive symptoms in youth, its associations with children's brain structure are not well understood. The striatum has been strongly implicated in depression in adolescents and adults. In this study, we investigated the associations among parental harsh discipline, striatal volume, and depressive symptoms in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dev.21859DOI Listing
  • Page 1 of 553807