1,074 results match your criteria Journal of clinical medicine research[Journal]


Does Metformin Assist New Anti-Diabetic Drugs to Succeed?

J Clin Med Res 2019 Feb 5;11(2):151-155. Epub 2019 Jan 5.

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.

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http://dx.doi.org/10.14740/jocmr3706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340680PMC
February 2019

Massive Hemoptysis Due to the Rupture of Thoracic Aortic Aneurysm Caused by Leukemic Cell Infiltration in a Patient With Chronic Myelomonocytic Leukemia.

J Clin Med Res 2019 Feb 5;11(2):145-150. Epub 2019 Jan 5.

Department of Clinical Pathology, Asahi General Hospital, Chiba, Japan.

Hemoptysis is occasionally experienced in patients with hematological malignancies who have respiratory tract infection and severe thrombocytopenia. Thrombocytopenia due to hematological disease is one cause of hemoptysis. Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy characterized by both a myeloproliferative neoplasm and a myelodysplastic syndrome. Read More

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http://dx.doi.org/10.14740/jocmr3712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340676PMC
February 2019
1 Read

Factors Influencing the Results in Matrix-Associated Autologous Chondrocyte Implantation: A 2 - 5 Year Follow-Up Study.

J Clin Med Res 2019 Feb 5;11(2):137-144. Epub 2019 Jan 5.

Department of Orthopedics, Ankara Yildirim Beyazit University, Ankara, Turkey.

Background: This study aimed to investigate the outcomes of matrix-associated autologous chondrocyte implantation (MACI) on the treatment of osteochondral lesions in the knee joint and to determine the factors affecting the functional results.

Methods: The study included 34 patients with a cartilage defect in the knee joint who were applied MACI® (GenzymeBiosurgery, Cambridge, Massachusetts, USA) technique between the years 2010 - 2015. The defect localizations and sizes, past surgeries were recorded. Read More

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http://dx.doi.org/10.14740/jocmr3711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340672PMC
February 2019

The Gonadotropin-Releasing Hormone Analogue Therapy May Not Impact Final Height in Precocious Puberty of Girls With Onset of Puberty Aged 6 - 8 Years.

J Clin Med Res 2019 Feb 5;11(2):133-136. Epub 2019 Jan 5.

Department of Pediatric Endocrinology, School of Medicine, Ege University, Izmir, Turkey.

Background: The effect on final height of gonadotropin-releasing hormone analogues (GnRHa) used in the treatment of precocious puberty is controversial. The aim of this study was to determine whether or not GnRHa therapy would make any contribution to final height in precocious puberty of girls with onset of pubertal characteristic development aged 6 - 8 years.

Methods: Age at start of puberty, target height standard deviation score (SDS) presentation, follow-up height SDS, body mass index (BMI) SDS, bone age and predicted adult height of 34 female subjects who had reached their final height and with pubertal findings beginning at the ages of 6 - 8 were evaluated. Read More

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http://dx.doi.org/10.14740/jocmr3710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340673PMC
February 2019

Effect of Troponin I Elevation on Duration of Mechanical Ventilation and Length of Intensive Care Unit Stay in Patients With Sepsis.

J Clin Med Res 2019 Feb 5;11(2):127-132. Epub 2019 Jan 5.

University of Khartoum, Khartoum, Sudan.

Background: Sepsis is a leading cause of mortality and morbidity. Recent studies suggest that troponin elevation is associated with increased mortality in sepsis patients. The purpose of this study is to determine the effect of troponin elevation on mechanical ventilation duration and intensive care unit (ICU) length of stay in patients with sepsis. Read More

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http://dx.doi.org/10.14740/jocmr3713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340681PMC
February 2019
2 Reads

To Use or Not to Use Opioid Analgesia for Acute Abdominal Pain Before Definitive Surgical Diagnosis? A Systematic Review and Network Meta-Analysis.

J Clin Med Res 2019 Feb 5;11(2):121-126. Epub 2019 Jan 5.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TG, UK.

Background: Despite the existing evidence, many physicians are reluctant to use opioid analgesia for acute abdominal pain.

Methods: We performed updated conventional and network meta-analyses. For the first time to our knowledge, direct and indirect evidence of any type of opioid analgesia was estimated and compared using network meta-analysis. Read More

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http://dx.doi.org/10.14740/jocmr3690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340675PMC
February 2019

Assessment of Salivary Nitric Oxide Levels in Elite University Athletes in Japan: Findings From a Cross Sectional Study Design.

J Clin Med Res 2019 Feb 5;11(2):114-120. Epub 2019 Jan 5.

Faculty of Health and Sports Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.

Background: High-intensity exercise affects the level of salivary nitric oxide (NO) with an impact on oxidative stress such as a reactive nitrogen-oxide species. However, in athletes with high-intensity training, the relationship between salivary NO levels and oxidative stress is yet to be clear. Additionally, the association of salivary NO levels and the common health disorders of athletes is unknown. Read More

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http://dx.doi.org/10.14740/jocmr3670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340678PMC
February 2019

Bleeding Complications in Warfarin-Treated Patients Admitted to the Emergency Department.

J Clin Med Res 2019 Feb 5;11(2):106-113. Epub 2019 Jan 5.

Department of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.

Background: Increased use of warfarin for the treatment and prophylaxis of many diseases has increased the frequency of adverse events. Emergency departments (EDs) are the first places where early interventions for bleeding and other complaints related to warfarin use are performed. This study assessed the characteristics of patients receiving warfarin and the risk factors for bleeding complication among those admitted to the ED. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3669
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http://dx.doi.org/10.14740/jocmr3669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340679PMC
February 2019
2 Reads

Cytoskeletal Tropomyosin as a Biomarker in Infection.

J Clin Med Res 2019 Feb 5;11(2):98-105. Epub 2019 Jan 5.

Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Background: Current diagnostics of infection (CDI) heavily relies on detection of the disease-causing organism. The objective of this study was to investigate a cytoskeletal protein, tropomyosin (Tpm), as a CDI biomarker.

Methods: Fecal Tpm was tested by monoclonal antibodies (mAbs) in a 12-month prospective study. Read More

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http://dx.doi.org/10.14740/jocmr3696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340674PMC
February 2019
1 Read

Investigation of a Dipeptidyl Peptidase-4 Inhibitor/Thiazolidinedione Combination Drug for Patients With Type 2 Diabetes and Poor Glycemic Control: Difficulty With Patient Enrollment.

J Clin Med Res 2019 Feb 5;11(2):89-97. Epub 2019 Jan 5.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Chikushino, Japan.

Background: One of the treatment options for type 2 diabetes mellitus (DM) is a combination drug (CD) that contains the dipeptidyl peptidase-4 inhibitor (DPP4I) alogliptin (AG) together with pioglitazone (PG). This CD can improve impaired insulin secretion and insulin resistance, which are the two major pathologic factors for type 2 DM, and is also expected to increase adherence to treatment. We conducted a multicenter open-label prospective study to examine the usefulness of this CD for routine management of type 2 DM. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3558
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http://dx.doi.org/10.14740/jocmr3558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340677PMC
February 2019
2 Reads

Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.

J Clin Med Res 2019 Feb 5;11(2):81-88. Epub 2019 Jan 5.

Department of Gastroenterology and Hepatology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.

Primary sclerosing cholangitis (PSC) is a chronic and progressive disease of the biliary tract. PSC is strongly associated with inflammatory bowel disease (IBD), mainly with ulcerative colitis, and most PSC patients have underlying IBD. The pathophysiological interactions between IBD and PSC are unclear, although it seems that the patients with IBD and PSC have a distinct phenotype. Read More

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http://dx.doi.org/10.14740/jocmr3680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340671PMC
February 2019
1 Read

An Effective Insulin Therapy in Combination With Sodium-Glucose Cotransporter 2 Inhibitors.

J Clin Med Res 2019 Jan 3;11(1):76-79. Epub 2018 Dec 3.

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.

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http://dx.doi.org/10.14740/jocmr3676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306135PMC
January 2019

Persistent Primitive Hypoglossal Artery Associated With Multiple Cerebral Aneurysms.

J Clin Med Res 2019 Jan 3;11(1):72-75. Epub 2018 Dec 3.

Department of Neurosurgery, Kanto Rosai Hospital, Kawasaki, Japan.

Persistent primitive hypoglossal artery is a rare anastomosis between the carotid and basilar arteries, and sometimes associated with cerebral aneurysms. However, association of persistent primitive hypoglossal artery with aneurysms located on arteries other than persistent primitive hypoglossal artery itself or posterior circulation is very rare. An 80-year-old woman suffered from subarachnoid hemorrhage, whose angiography demonstrated aneurysms on the left middle cerebral artery and anterior communicating artery, and the left persistent primitive hypoglossal artery. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3649
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http://dx.doi.org/10.14740/jocmr3649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306131PMC
January 2019
7 Reads

The Role of Exercise in the Quality of Life in Patients After Pancreatectomy: A Prospective Randomized Controlled Trial.

J Clin Med Res 2019 Jan 3;11(1):65-71. Epub 2018 Dec 3.

School of Physical Education and Sports Sciences at Serres, "Aristotle" University, Thessaloniki, Greece.

Background: Pancreatic resection is still a challenging operation characterised by high morbidity. The quality of life in patients after pancreatectomy is a critical outcome. The aim of our trial is to prove whether or not exercise has any benefit to the life of these patients. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3675
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http://dx.doi.org/10.14740/jocmr3675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306133PMC
January 2019
5 Reads

Acute Appendicectomy or Conservative Treatment for Complicated Appendicitis (Phlegmon or Abscess)? A Systematic Review by Updated Traditional and Cumulative Meta-Analysis.

J Clin Med Res 2019 Jan 3;11(1):56-64. Epub 2018 Dec 3.

Department of Colorectal Surgery, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

Background: The existing evidence on the treatment of complicated appendicitis favors conservative treatment rather than acute appendicectomy. Update traditional meta-analysis and consequently cumulative meta-analysis was performed to track the accumulation of evidence over time.

Methods: Studies were identified by a systematic literature search of the EMBASE, PubMed, Cochrane Library and Google Scholar databases. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3672
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http://dx.doi.org/10.14740/jocmr3672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306138PMC
January 2019
7 Reads

Renoprotective Benefit of Tolvaptan in Acute Decompensated Heart Failure Patients With Loop Diuretic-Resistant Status.

J Clin Med Res 2019 Jan 3;11(1):49-55. Epub 2018 Dec 3.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyouin, Chikushino, Fukuoka 818-8502, Japan.

Background: While reduction of accumulated body fluid using loop diuretics is a commonly used therapeutic option for acute heart failure (AHF), some patients, especially those with chronic kidney disease (CKD), show significantly poor treatment response to loop diuretics. Tolvaptan (TLV) has shown effectiveness against AHF in several studies. We have been using TLV for AHF treatment, and it displayed favorable outcome even in patients with CKD. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3671
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http://dx.doi.org/10.14740/jocmr3671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306139PMC
January 2019
5 Reads

Gastrointestinal Bleeding in Patients With Acute Respiratory Distress Syndrome: A National Database Analysis.

J Clin Med Res 2019 Jan 3;11(1):42-48. Epub 2018 Dec 3.

Department of Pulmonary & Critical Care, Staten Island University Hospital, Northwell Health, NY, USA.

Background: The goal of our study was to determine the impact of gastrointestinal bleeding (GIB) on in-hospital outcomes among acute respiratory distress syndrome (ARDS) patients, and subsequently determine the potential risk factors for the development of GIB.

Methods: ARDS patients with and without GIB were identified using the National Inpatient Sample (2002 - 2012). Linear regression analysis was used to assess impact of GIB on in-hospital mortality, length of stay and total charges. Read More

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http://dx.doi.org/10.14740/jocmr3660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306132PMC
January 2019
1 Read

Residual Effect of Sodium Glucose Cotransporter 2 Inhibitor, Tofogliflozin, on Body Weight After Washout in Japanese Men With Type 2 Diabetes.

J Clin Med Res 2019 Jan 3;11(1):35-41. Epub 2018 Dec 3.

Kanazawa Medical University, Ishikawa, Japan.

Background: We investigated the potential mechanism underlying body weight reduction by the sodium glucose cotransporter 2 (SGLT2) inhibitor, tofogliflozin, during treatment and after subsequent washout.

Methods: Ten Japanese men with type 2 diabetes (average age: 66.3 years) were orally administered tofogliflozin (20 mg/day) for 8 weeks followed by a subsequent 8-week washout period (16 weeks). Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3650
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http://dx.doi.org/10.14740/jocmr3650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306130PMC
January 2019
1 Read

Alcohol Withdrawal: Possible Risk of Latent Scurvy Appearing as Tiredness: A STROBE-Compliant Study.

J Clin Med Res 2019 Jan 3;11(1):26-34. Epub 2018 Dec 3.

Nouvelle Clinique des Trois Frontieres, 8, rue Saint Damien 68300 Saint-Louis, France.

Background: Little is known about the prevalence of vitamin C deficiency in the population of individuals who are withdrawing from alcohol, and about possible consequences of latent scurvy. The aim of this study was to evaluate the prevalence of vitamin C deficiency in patients who were withdrawing from alcohol, its correlation with latent scurvy (mainly tiredness and weakness) and the change in the latter symptoms at 3 months after oral vitamin C supplementation.

Methods: A total of 47 patients (33 males, 14 females) who volunteered to undertake alcohol detoxification were included prospectively between January 2014 and November 2016. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3643
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http://dx.doi.org/10.14740/jocmr3643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306134PMC
January 2019
6 Reads

Obstructive Sleep Apnea Screening in Patients With Atrial Fibrillation: Missed Opportunities for Early Diagnosis.

J Clin Med Res 2019 Jan 3;11(1):21-25. Epub 2018 Dec 3.

Department of Internal Medicine, Staten Island University Hospital Staten Island, 475 Seaview Ave, Staten Island, NY 10305, USA.

Background: "There is a high prevalence of obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF). There is also strong evidence that proper OSA management can reduce AF recurrence." Polysomnography is the gold standard for OSA diagnosis, but screening tests, such as STOP-BANG, have been successful in identifying patients at risk for OSA. Read More

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http://dx.doi.org/10.14740/jocmr3635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306129PMC
January 2019
1 Read

Effects of Sitagliptin on Pancreatic Beta-Cells in Type 2 Diabetes With Sulfonylurea Treatment: A Prospective Randomized Study.

J Clin Med Res 2019 Jan 3;11(1):15-20. Epub 2018 Dec 3.

Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Background: This prospective randomized, multicenter, open-label, comparative study was performed to analyze the effects of sitagliptin on glycemic control and maintenance of beta-cell function in patients with poorly controlled type 2 diabetes treated with low-dose glimepiride.

Methods: Forty-one patients with type 2 diabetes mellitus treated with low-dose glimepiride (≤ 2 mg/day) were prospectively enrolled in this study (age: 20 - 75 years; hemoglobin A1c (HbA1c): 7.4- 9. Read More

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http://dx.doi.org/10.14740/jocmr3632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306137PMC
January 2019
6 Reads

Quality Improvement in Ambulatory Surgery Centers: A Major National Effort Aimed at Reducing Infections and Other Surgical Complications.

J Clin Med Res 2019 Jan 3;11(1):7-14. Epub 2018 Dec 3.

Ariadne Labs, A Joint Center Between Brigham and Women's Hospital and the Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: Surgical volume has shifted significantly from inpatient to outpatient settings, including free-standing ambulatory surgery centers (ASCs). Approaches to quality improvement (QI) and surveillance used in hospitals are not always appropriate to the ambulatory setting.

Methods: We recruited 665 ASCs in 47 US states to participate in an intervention to improve safe practice through implementation of a surgical safety checklist and infection control practices. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3603
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http://dx.doi.org/10.14740/jocmr3603wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306128PMC
January 2019
5 Reads

Risk Factors Associated With Recurrent Infection.

J Clin Med Res 2019 Jan 3;11(1):1-6. Epub 2018 Dec 3.

Department of Internal Medicine at Cooper University Hospital, 1103 North Kings Highway Suite 203, Cherry Hill, NJ 08034, USA.

Background: Recurrence of infection (CDI) is a problem that can cost up to $20,000 each year in the United States. Studies have reported risk factors that may be associated with a higher incidence of recurrent CDI. We studied additional risk factors, including history of partial colectomy, chemotherapy use and hospitalization in the intensive care unit (ICU). Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3531
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http://dx.doi.org/10.14740/jocmr3531wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306136PMC
January 2019
3 Reads

Which Nutritional Factors Are Good for HDL?

J Clin Med Res 2018 Dec 30;10(12):936-939. Epub 2018 Oct 30.

The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.14740/jocmr3646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225857PMC
December 2018

Clinical Impact of Hemorheology on Subclinical Myocardial Injury in Patients with Hypertension.

J Clin Med Res 2018 Dec 30;10(12):928-935. Epub 2018 Oct 30.

Hitsumoto Medical Clinic, Yamaguchi, Japan.

Background: The blood concentration of high-sensitivity cardiac troponin T (hs-cTnT) is a useful biomarker for myocardial injury or the pathogenesis of hypertension. Little is known about the relationship between hemorheology and myocardial injury in patients with hypertension. This cross-sectional study aimed to clarify the clinical impact of hemorheology on subclinical myocardial injury assessed with a microchannel array flow analyzer (MC-FAN) and its impact on hs-cTnT in patients with hypertension. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3652
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http://dx.doi.org/10.14740/jocmr3652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225855PMC
December 2018
6 Reads

Relationship Between Sarcopenia and Both Physical Activity and Lifestyle in Patients With Chronic Liver Disease.

J Clin Med Res 2018 Dec 30;10(12):920-927. Epub 2018 Oct 30.

Department of Nursing, Niigata University Graduate School of Health Sciences, Niigata, Japan.

Background: Sarcopenia can affect the prognosis of patients with cirrhosis or hepatocellular carcinoma. Exercise therapy and nutritional therapy are carried out to prevent processing sarcopenia. In addition, changing lifestyle is also important. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3640
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http://dx.doi.org/10.14740/jocmr3640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225858PMC
December 2018
18 Reads

Comparison of Comorbid Conditions Between Cancer Survivors and Age-Matched Patients Without Cancer.

J Clin Med Res 2018 Dec 30;10(12):911-919. Epub 2018 Oct 30.

Cooper Research Institute, Cooper Medical School of Rowan University, Camden, NJ, USA.

Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer.

Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Read More

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http://dx.doi.org/10.14740/jocmr3617wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225860PMC
December 2018
4 Reads

Prevalence and Risk Factors of Elevated Liver Enzymes in Japanese Women With Polycystic Ovary Syndrome.

J Clin Med Res 2018 Dec 30;10(12):904-910. Epub 2018 Oct 30.

Graduate School of Human Science and Environment, University of Hyogo, Hyogo, Japan.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-aged women. While PCOS is associated with an increased risk of obesity and insulin resistance, little is known regarding the prevalence of and risk factors for nonalcoholic fatty liver disease (NAFLD) among Japanese women with PCOS. We estimated the prevalence of and risk factors for elevated liver enzymes, as the index of NAFLD, in Japanese women with PCOS. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3639
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http://dx.doi.org/10.14740/jocmr3639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225863PMC
December 2018
14 Reads

APACHE II Death Risk and Length of Stay in the ICU Are Associated With Pressure Injury in Critically Ill Patients.

J Clin Med Res 2018 Dec 30;10(12):898-903. Epub 2018 Oct 30.

Department of Fundamental Nursing, University of Sao Paulo at Ribeirao Preto College of Nursing, Ribeirao Preto, Sao Paulo, Brazil.

Background: The aim of this study was to identify factors associated with pressure injury (PI) occurrence in critically ill patients. This was a retrospective cohort study conducted at a mixed intensive care unit (ICU).

Methods: Univariate analysis and logistic regression were used to identify which variables are associated with PI. Read More

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http://dx.doi.org/10.14740/jocmr3636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225865PMC
December 2018

Pneumonia: Walking Pneumonia Can Cripple the Susceptible.

J Clin Med Res 2018 Dec 30;10(12):891-897. Epub 2018 Oct 30.

Division of Pulmonary and Critical Care Medicine, Bronx Care Health System, Bronx, NY 10457, USA.

Background: pneumonia (MPP), or "walking pneumonia," is an atypical mild disease with varied clinical findings. Specifically, diagnosis is often controversial and understanding of disease presentation is limited. The goal of the study was to evaluate presentation, clinical associations and outcomes of MPP patients admitted to an inner-city hospital. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3592
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http://dx.doi.org/10.14740/jocmr3592wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225856PMC
December 2018
9 Reads

Clinical Usefulness of the Cardio-Ankle Vascular Index as a Predictor of Primary Cardiovascular Events in Patients With Chronic Kidney Disease.

J Clin Med Res 2018 Dec 30;10(12):883-890. Epub 2018 Oct 30.

Hitsumoto Medical Clinic, 2-7-7, Takezakicyou, Shimonoseki City, Yamaguchi, 750-0025, Japan. Email:

Background: The cardio-ankle vascular index (CAVI) is a physiologic marker reflecting arterial function. There have been no prospective studies investigating the relationship between CAVI and cardiovascular events in patients with chronic kidney disease (CKD). The aim of this prospective study was to assess the clinical usefulness of CAVI as a predictor of primary cardiovascular events in patients with CKD. Read More

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http://dx.doi.org/10.14740/jocmr3631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225859PMC
December 2018

Present Status and Perspectives on Future Roles of Japanese Clinical Research Coordinators.

J Clin Med Res 2018 Dec 30;10(12):877-882. Epub 2018 Oct 30.

Integrated Center for Advanced Medical Technologies, Kochi Medical School Hospital, Kochi, Japan.

Background: The new Clinical Trials Act that recently came into effect in Japan emphasizes the reliability of investigator-initiated clinical trials. Although Japanese clinical research coordinators have been mainly engaged in operational roles in industry-initiated clinical trials for drug approval (registration trials), broadening their contribution to cover more types of clinical research may lead to quality improvement of clinical research. To ultimately establish a clinical research infrastructure that meets the needs of the new era of Clinical Trials Act, here we gathered basic information on how clinical research coordinators might make such contributions. Read More

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http://dx.doi.org/10.14740/jocmr3602wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225862PMC
December 2018

The Effects of Geography on Outcomes of Routine Early Versus Selective Late Revascularization Strategy in the Treatment of Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Transatlantic Randomized Controlled Trials.

J Clin Med Res 2018 Dec 30;10(12):868-876. Epub 2018 Oct 30.

Department of Cardiovascular Diseases, Einstein Medical Center, Philadelphia, PA, USA.

Background: The optimal timing of revascularization in unstable angina (UA) or non-ST-segment elevation myocardial infarction (NSTEMI) remains uncertain. We compared routine early revascularization (REV) versus selective late revascularization (SLR) strategies and divergence in the approach of cardiologists in the United States and Europe.

Methods: Seventeen randomized controlled trials (RCTs) (15,812 patients) were extracted from PubMed, Cochrane Library, EMBASE and Web of Science databases. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3585
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http://dx.doi.org/10.14740/jocmr3585wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225861PMC
December 2018
9 Reads

Biovigilance for the Quality and Safety of Medical Products of Human Origin.

J Clin Med Res 2018 Dec 30;10(12):857-867. Epub 2018 Oct 30.

The Onassis Cardiac Surgery Center, Cardiac Surgery Intensive Care Unit, National and Kapodistrian University of Athens, Athens, Greece.

Progress in science and technology in the health services has led to the development of methods of regenerating and replacing solid organs, tissues and cells, using human body components to create medical products of human origin intended for clinical use. In the activities in which products of human origin are used, however, from the point of donation and harvesting to the subsequent care of the recipient, medical products of human origin are exposed to the risk of specific complications related to the transmission of infectious diseases, and further side-effects. Biovigilance system application is a basic requirement for ensuring the quality and safety of tissues and cells intended for human use. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3549
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http://dx.doi.org/10.14740/jocmr3549wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225864PMC
December 2018
8 Reads

Retraction Notice to: Brain Natriuretic Peptide Levels in Acute Inferior Myocardial Infarction.

Authors:

J Clin Med Res 2018 Nov 9;10(11):855. Epub 2018 Oct 9.

[This retracts the article DOI: 10.14740/jocmr3324w.]. Read More

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http://dx.doi.org/10.14740/jocmr3324wrDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188022PMC
November 2018

A New Approach for Hypertension: the Case of Sacubitril/Valsartan Experienced in Randomized Controlled Trials That Selectively Restrict Its Use to the Hypertension of the Elderly.

J Clin Med Res 2018 Nov 9;10(11):853-854. Epub 2018 Oct 9.

Preventive Cardiology and Rehabilitation Unit, DSB 29 "S. Gennaro dei Poveri Hospital", via S.Gennaro dei Poveri 25, 80136 Napoli, Italy.

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http://dx.doi.org/10.14740/jocmr3593wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188021PMC
November 2018

Fashionably Late: A Case of Delayed Cutaneous Manifestations in Juvenile Dermatomyositis.

J Clin Med Res 2018 Nov 9;10(11):848-852. Epub 2018 Oct 9.

Department of Pediatrics, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX, USA.

Juvenile dermatomyositis (JDM) is a rare, but well recognized multi-systemic inflammatory myopathy in children defined by proximal muscle weakness and distinctive skin lesions, that if recognized and treated early result in decreased morbidity and mortality. The 1975 criteria established by Bohan and Peter center around the propensity for early development of heliotrope and Gottron's lesions in combination with specific laboratory abnormalities, and are still the leading diagnostic tool. The following case demonstrates a toddler with an atypical presentation of JDM in which delayed dermatologic manifestations hindered initial diagnosis. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3547
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http://dx.doi.org/10.14740/jocmr3547wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188024PMC
November 2018
9 Reads

Gastrinoma of Cystic Duct: A Rare Association With Multiple Endocrine Neoplasia Type 1.

J Clin Med Res 2018 Nov 9;10(11):843-847. Epub 2018 Oct 9.

Department of Internal Medicine and Endocrine Unit, Medical School and Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Neuroendocrine tumors (NETs) of cystic duct are extremely rare, accounting for less than 2% of NET cases. The association of biliary tree NET and multiple endocrine neoplasm type 1 (MEN1) are even more rare. In this report, we described a case of a 65-year-old woman who was referred to our neuroendocrine outpatient clinic to investigate MEN1 after an incidental diagnosis of gastrinoma. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3541
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http://dx.doi.org/10.14740/jocmr3541wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188020PMC
November 2018
15 Reads

Effects of Repaglinide Versus Glimepiride on 1,5-Anhydroglucutol and Glycated Hemoglobin Levels in Japanese Patients With Type 2 Diabetes.

J Clin Med Res 2018 Nov 9;10(11):838-842. Epub 2018 Oct 9.

Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan.

Background: Postprandial hyperglycemia is a well-known risk factor for cardiovascular disease. We prospectively examined the effects of repaglinide on postprandial hyperglycemia in patients with type 2 diabetes.

Methods: During this 24-week, single-arm, prospective study, we enrolled 10 patients with type 2 diabetes who were previously being administered glimepiride (0. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3618
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http://dx.doi.org/10.14740/jocmr3618wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188029PMC
November 2018
5 Reads

Higher Fasting and Postprandial Free Fatty Acid Levels Are Associated With Higher Muscle Insulin Resistance and Lower Insulin Secretion in Young Non-Obese Women.

J Clin Med Res 2018 Nov 9;10(11):822-829. Epub 2018 Oct 9.

Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.

Background: To assess the relationship of the shape of glucose concentration curve during a standardized meal test to serum free fatty acid (FFA) concentrations, insulin resistance and insulin secretion in young non-obese women.

Methods: Thirty-five young women had a standardized meal for breakfast with measurement of glucose, insulin and FFA concentrations at 0 (fasting), 30, 60 and 120 min; the areas under the concentration curves were calculated (AUCg, AUCi and AUCffa, respectively). Meal-induced insulin response (MIR) was calculated as the ratio between the incremental insulin and glucose concentrations during the first 30 min of meal tests. Read More

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http://dx.doi.org/10.14740/jocmr3534wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188023PMC
November 2018

The Effect of Status on Radio-Sensitivity of Quiescent Tumor Cell Population Irradiated With γ-Rays at Various Dose Rates.

J Clin Med Res 2018 Nov 9;10(11):815-821. Epub 2018 Oct 9.

Kansai BNCT Collaborative Research Center, Osaka Medical College, 2-7, Daigaku-cho, Takatsuki, Osaka 569-8686, Japan.

Background: The aim of the study was to clarify the effect of status of tumor cells on radio-sensitivity of solid tumors following γ-ray irradiation at various dose rates, referring to the response of intratumor quiescent (Q) cells.

Methods: Human head and neck squamous cell carcinoma cells transfected with mutant (SAS/) or with neo vector (SAS/) were injected subcutaneously into hind legs of nude mice. Tumor bearing mice received 5-bromo-2'-deoxyuridine (BrdU) continuously to label all intratumor proliferating (P) cells. Read More

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http://dx.doi.org/10.14740/jocmr3610wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188028PMC
November 2018

Drug-Drug Interaction Assessment and Identification in the Primary Care Setting.

J Clin Med Res 2018 Nov 9;10(11):806-814. Epub 2018 Oct 9.

Aegis Sciences Corporation, Nashville, TN, USA.

Background: Drug-drug interactions (DDIs) are ubiquitous, harmful and a leading cause of morbidity and mortality. With an aging population, growth in polypharmacy, widespread use of supplements, and the rising opioid abuse epidemic, primary care physicians (PCPs) are increasingly challenged with identifying and preventing DDIs. We set out to evaluate current clinical practices related to identifying and treating DDIs and to determine if opportunities to increase prevention of DDIs and their adverse events could be identified. Read More

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http://dx.doi.org/10.14740/jocmr3557wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188027PMC
November 2018
1 Read

Possibility of a New Therapeutic Strategy for Left Ventricular Dysfunction in Type 2 Diabetes.

J Clin Med Res 2018 Nov 9;10(11):799-805. Epub 2018 Oct 9.

Department of Cardiology, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.

Type 2 diabetes mellitus (T2DM) substantially increases the risk of cardiovascular events, including heart failure (HF), due to complications such as hypertension, obesity and dyslipidemia based on metabolic syndrome, which plays the central pathological role in HF. A reason is that T2DM causes left ventricular (LV) diastolic dysfunction beginning in the early phase of the disease, which in turn increases the risk of development of HF independently of the control of blood glucose levels, blood pressure or the presence of coronary artery diseases. Intracellular metabolic disorders and increased oxidative stress due to hyperglycemia, increased insulin resistance and chronic inflammation are pathogenic mechanisms involved in the LV diastolic dysfunction caused by T2DM. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3584
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http://dx.doi.org/10.14740/jocmr3584wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188026PMC
November 2018
10 Reads

Strong Association Between Weight Reduction and Suppression of Cardiovascular Events in Recent Clinical Trials of DPP4 Inhibitors, GLP-1 Receptor Agonists, and SGLT2 Inhibitors.

Authors:
Tatsuo Yanagawa

J Clin Med Res 2018 Oct 10;10(10):796-797. Epub 2018 Sep 10.

Department of Medicine, Nerima General Hospital and Institute of Healthcare Quality Improvement, Public Interest Incorporated Foundation Tokyo Healthcare Foundation, 1-24-1 Asahigaoka, Nerima-Ku, Tokyo 176-8530, Japan. Email:

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http://dx.doi.org/10.14740/jocmr3587wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135005PMC
October 2018
2 Reads

A Different Effect of an Orexin Receptor Antagonist on Metabolic Parameters Between Diabetic Patients and Non-Diabetic Patients.

J Clin Med Res 2018 Oct 10;10(10):795. Epub 2018 Sep 10.

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.

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http://www.jocmr.org/index.php/JOCMR/article/view/3537
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http://dx.doi.org/10.14740/jocmr3537wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135004PMC
October 2018
2 Reads

Dabigatran-Induced Acute Interstitial Nephritis: An Important Complication of Newer Oral Anticoagulation Agents.

J Clin Med Res 2018 Oct 10;10(10):791-794. Epub 2018 Sep 10.

Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.

Acute kidney injury (AKI) due to an acute interstitial nephritis (AIN) is common and can lead to increased morbidity and mortality. Medications such as antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPI) and rifampin are common offending agents. Anticoagulant-associated AIN is more frequently reported with the use of warfarin; however, only few case reports have reported an association with the use of novel oral anticoagulants (NOACs). Read More

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http://dx.doi.org/10.14740/jocmr3569wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134997PMC
October 2018
2 Reads

Methimazole-Induced Pauci-Immune Glomerulonephritis and Anti-Phospholipid Syndrome: An Important Association to Be Aware of.

J Clin Med Res 2018 Oct 10;10(10):786-790. Epub 2018 Sep 10.

Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.

While methimazole (MMI) is the first line treatment for hyperthyroidism, this medication is not devoid of adverse effects. In this article, we present a 70-year-old male who admitted the hospital with right lower extremity pain and rash. The patient was recently treated with MMI for hyperthyroidism. Read More

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http://dx.doi.org/10.14740/jocmr3530wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135002PMC
October 2018
3 Reads

Pulmonary Artery Pseudoaneurysms in the Setting of Gout Polyarthropathy: A Case Report.

J Clin Med Res 2018 Oct 10;10(10):781-785. Epub 2018 Sep 10.

Radiology Department, The Prince Charles Hospital, Chermside, QLD 4032, Australia.

Pulmonary artery pseudoaneurysm is a dangerous pathology often missed as a differential and on imaging. With a 50% mortality rate early detection and intervention are critical to patient outcome, rendering diagnosis based on clinical grounds to be of paramount importance. A high index of suspicion should be placed on patients presenting with unprovoked hemoptysis, hemorrhage or hemothorax. Read More

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http://dx.doi.org/10.14740/jocmr3513wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135000PMC
October 2018
2 Reads

Recommendations of Lifestyle Modification According to a Survey of First-Year University Students.

J Clin Med Res 2018 Oct 10;10(10):772-780. Epub 2018 Sep 10.

Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

Background: We analyzed what kind of lifestyle modification first-year university students need based on the results of a health-consciousness survey conducted in first-year students immediately after they entered a university.

Methods: This population-based cross-sectional study used a "questionnaire survey on lifestyle and health for promoting health" conducted in Japan in 2015. From among an initial pool of 3,912 students, we excluded 314 due to insufficient data. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3574
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http://dx.doi.org/10.14740/jocmr3574wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134998PMC
October 2018
5 Reads