1,097 results match your criteria Journal of clinical medicine research[Journal]


Secondary Prevention of Atrial Fibrillation: Is It Worth Doing?

J Clin Med Res 2019 Apr 18;11(4):309. Epub 2019 Mar 18.

Preventive Cardiology and Rehabilitation Unit, DSB 29 "S.Gennaro dei Poveri Hospital", via S.Gennaro dei Poveri 25, 80136 Napoli, Italy. Email:

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http://dx.doi.org/10.14740/jocmr3810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436569PMC
April 2019
1 Read

Complete Occlusion of Bilateral Internal Carotid Artery in a Marijuana Smoker: A Case Report.

J Clin Med Res 2019 Apr 18;11(4):305-308. Epub 2019 Mar 18.

Department of Neurology, Staten Island University Hospital, Staten Island, NY 10305, USA.

Here we described a case of a young male who developed stroke attributable to heavy marijuana smoking. Although, instances of stroke due to cannabis smoking have been reported earlier, this case is distinctive due to the fact that the patient had bilateral complete occlusion of internal carotid artery (ICA) at a very early age. In view of studies that have correlated marijuana smoking to intracranial stenosis and atherogenesis, this case of bilateral ICA occlusion illustrates the severity and burden of the disease. Read More

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http://dx.doi.org/10.14740/jocmr3132wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436573PMC
April 2019
1 Read

HIV-Infected Patient Diagnosed With Osteomedullary and Hepatic Syphilis on Positron Emission Tomography: A Case Report.

J Clin Med Res 2019 Apr 18;11(4):301-304. Epub 2019 Mar 18.

Department of Internal Medicine, Centre Hospitalier de l'Universite de Montreal (CHUM), 1051 rue Sanguinet, H2X 3E4, Montreal, QC, Canada.

A human immunodeficiency virus (HIV)-positive man presented with a recent history of weight loss and B symptoms. Positron emission tomography (PET) scan revealed multiple hypercaptation foci, including diffuse osteomedullary lesions and a dominant liver nodule. Syphilis screening was positive, with a rapid plasma reagin (RPR) titer of 1:1,024. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3756
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http://dx.doi.org/10.14740/jocmr3756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436565PMC
April 2019
1 Read

Differing Effect of the Sodium-Glucose Cotransporter 2 Inhibitor Ipragliflozin on the Decrease of Fat Mass vs. Lean Mass in Patients With or Without Metformin Therapy.

J Clin Med Res 2019 Apr 18;11(4):297-300. Epub 2019 Mar 18.

Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.

Background: We previously reported changes of body composition determined by dual-energy X-ray absorptiometry after treatment with ipragliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor. In that study, mean body weight was decreased by 3.5 kg (4. Read More

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http://dx.doi.org/10.14740/jocmr3785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436566PMC

Associations of Pericardial Fat Area Determined by Routine Chest Computed Tomography With Coronary Risk Factors and Coronary Artery Disease.

J Clin Med Res 2019 Apr 18;11(4):289-296. Epub 2019 Mar 18.

Furugaki Diabetes Clinic, Chiba, Japan.

Background: Pericardial fat has been reported to be associated with coronary risk factors and severity of coronary arterial lesions. Previous studies had measured pericardial fat volume (PFV) by using contrast-enhanced cardiac computed tomography (CT) when pericardial fat was quantified. We determined pericardial fat area (PFA) in the cross section with the height of sternal angle by using routine chest CT. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3782
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http://dx.doi.org/10.14740/jocmr3782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436567PMC
April 2019
7 Reads

Nutritional Support of Very Low Birth Weight Infants in a Tertiary Center in a Developing Country.

J Clin Med Res 2019 Apr 18;11(4):283-288. Epub 2019 Mar 18.

School of Pharmacy, University of Jordan, Amman, Jordan.

Background: Very low birth weight infants (VLBWIs) are at high risk for nutritional deficiency. Enteral feeding is usually challenged by increased risk of necrotizing enterocolitis (NEC). The nutritional needs of VLBWIs are usually dependent on parenteral nutrition during early postnatal life. Read More

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http://dx.doi.org/10.14740/jocmr3797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436563PMC
April 2019
2 Reads

Prevalence of Solid Neoplasms Diagnosed Between the Years of 2011 to 2016 and Oncologically Treated at the University Hospital of Santa Maria.

J Clin Med Res 2019 Apr 18;11(4):275-282. Epub 2019 Mar 18.

Post-Graduate Program of Health Science, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.

Background: Cancer is a public health problem, especially in developing countries. In order to establish effective measures for the cancer control, there is a need for quality information, thus enabling a better understanding of the disease and its determinants, formulation of causal hypotheses, evaluation of the technological advances applied to prevention and treatment as well as the effectiveness of health care. The objective of the study was to investigate the prevalence of solid neoplasms diagnosed between the years 2011 to 2016 and treated at the Oncology Department of the University Hospital of Santa Maria and the existing oncological context. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3769
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http://dx.doi.org/10.14740/jocmr3769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436568PMC
April 2019
3 Reads

Renoprotective Effects of Additional SGLT2 inhibitor Therapy in Patients With Type 2 Diabetes Mellitus and Chronic Kidney Disease Stages 3b-4: A Real World Report From A Japanese Specialized Diabetes Care Center.

J Clin Med Res 2019 Apr 18;11(4):267-274. Epub 2019 Mar 18.

Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.

Background: Large randomized clinical trials of patients with type 2 diabetes mellitus (T2DM) and at high risk for cardiovascular disease revealed that sodium-glucose cotransporter 2 (SGLT2) inhibitors significantly reduced renal events. However, the trials included small numbers of patients with moderate-to-severe chronic kidney disease (CKD). Therefore, the renoprotective effects of SGLT2 inhibitors remain unknown in T2DM patients complicated with impaired renal function. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3761
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http://dx.doi.org/10.14740/jocmr3761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436561PMC
April 2019
4 Reads

Sleep Quality in Patients With Type 2 Diabetes Mellitus.

J Clin Med Res 2019 Apr 18;11(4):261-266. Epub 2019 Mar 18.

The National Center (Institute) for Diabetes, Endocrinology and Genetics/University of Jordan, Amman, Jordan.

Background: This study aims to evaluate the sleep quality in patients with type 2 diabetes mellitus (T2DM), and to assess the relevance of other factors to sleep quality.

Methods: A cross-sectional study was carried out at the National Center for Diabetes, Endocrinology and Genetics (NCDEG) in Amman, Jordan, during the period from October 1, 2015 to December 31, 2015. A total of 1,211 (540 male and 671 female) patients with T2DM were recruited. Read More

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http://dx.doi.org/10.14740/jocmr2947wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436571PMC

Long-Term Efficacy, Safety, and Tolerability of Modified Intravesical Oxybutynin Chloride for Neurogenic Bladder in Children.

J Clin Med Res 2019 Apr 18;11(4):256-260. Epub 2019 Mar 18.

Department of Urology, Tottori University Faculty of Medicine, Yonago, Tottori 683-8504, Japan.

Background: Children with spinal cord disorders can present with neurogenic bladder, a condition in which the bladder partly or completely loses its ability to store urine and void at low pressure. A bladder with low compliance may cause urinary incontinence, which negatively impacts quality of life and renal function. Long-term high pressure neurogenic bladder can increase the risk of deterioration in renal function. Read More

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http://dx.doi.org/10.14740/jocmr3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436562PMC

Association Between the Use of Thiazide Diuretics and the Risk of Skin Cancers: A Meta-Analysis of Observational Studies.

J Clin Med Res 2019 Apr 18;11(4):247-255. Epub 2019 Mar 18.

Department of Cardiovascular Sciences, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Background: Thiazide diuretics are among the most widely prescribed antihypertensive agents. Given their photosensitizing effects, however, there are concerns that they may increase the risk of skin cancers. In this meta-analysis, we investigated an association between the use of thiazide diuretics and the risk of skin cancers. Read More

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http://dx.doi.org/10.14740/jocmr3744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436572PMC

Peripheral Inserted Central Catheter Use and Related Infections in Clinical Practice: A Literature Update.

J Clin Med Res 2019 Apr 18;11(4):237-246. Epub 2019 Mar 18.

Department of Infectious Diseases, University of Patras, Greece, University Hospital of Patras, Greece.

Peripherally inserted central catheter (PICC) lines are commonly used by clinicians in daily practice. This strategy has been established the latest years as a common approach in many clinical conditions. Apart from their usefulness, PICC use is related to some complications. Read More

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http://dx.doi.org/10.14740/jocmr3757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436570PMC
April 2019
1 Read

Adverse Effects of Immune Checkpoint Inhibitors (Programmed Death-1 Inhibitors and Cytotoxic T-Lymphocyte-Associated Protein-4 Inhibitors): Results of a Retrospective Study.

J Clin Med Res 2019 Apr 18;11(4):225-236. Epub 2019 Mar 18.

Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA.

In recent years the use of immunomodulating therapy to treat various cancers has been on the rise. Three checkpoint inhibitors have been approved by the Food and Drug Administration (ipilimumab, pembrolizumab and nivolumab). The use of these drugs comes with serious adverse events related to excessive immune activation, collectively known as immune-related adverse events (irAEs). Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3750
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http://dx.doi.org/10.14740/jocmr3750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436564PMC
April 2019
8 Reads

Liraglutide Reduces Visceral and Intrahepatic Fat Without Significant Loss of Muscle Mass in Obese Patients With Type 2 Diabetes: A Prospective Case Series.

J Clin Med Res 2019 Mar 13;11(3):219-224. Epub 2019 Feb 13.

Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

Background: Glucagon-like peptide-1 receptor agonists have been reported to reduce body fat as well as improving glycemic control in obese patients with type 2 diabetes. However, the maximum dose of liraglutide is limited to 0.9 mg in Japan, while the international dose is 1. Read More

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http://dx.doi.org/10.14740/jocmr3647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396779PMC

Risk Factors of Hypoglycemic Encephalopathy and Prolonged Hypoglycemia in Patients With Severe Hypoglycemia.

J Clin Med Res 2019 Mar 13;11(3):213-218. Epub 2019 Feb 13.

Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical University, Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, Japan.

Background: The aim of the study was to investigate risk factors of hypoglycemic encephalopathy (HE) in patients with severe hypoglycemia.

Methods: We retrospectively enrolled patients with severe hypoglycemia who were transported to the emergency department in an ambulance. We defined severe hypoglycemia as plasma glucose level < 60 mg/dL (or capillary levels < 50 mg/dL). Read More

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http://dx.doi.org/10.14740/jocmr3728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396785PMC
March 2019
2 Reads

A Retrospective Study of Kidney Stone Recurrence in Adults.

J Clin Med Res 2019 Mar 13;11(3):208-212. Epub 2019 Feb 13.

Department of Urology Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated With Guangzhou University of Chinese Medicine, Zhongshan City, China.

Background: Nephrolithiasis or kidney stone disease (KSD) is a common disorder worldwide. Despite the availability of a variety of effective management strategies, KSD recurrence remains a problem. In the present study, we investigated the KSD recurrence after the treatment of the first stone episode. Read More

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http://dx.doi.org/10.14740/jocmr3753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396780PMC
March 2019
4 Reads

Effect of Switching to Azilsartan From Fixed-Dose Combination of an Angiotensin II Receptor Blocker and Calcium Channel Blocker or a Thiazide in Patients With Hypertension.

J Clin Med Res 2019 Mar 13;11(3):202-207. Epub 2019 Feb 13.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: Despite the availability of antihypertensive treatments, fewer than half of patients who receive treatment successfully achieve blood pressure (BP) goals. The purpose of this study was to evaluate the effect of switching to azilsartan 40 mg from a fixed-dose combination tablet of an angiotensin II receptor blocker (ARB) and amlodipine at 5 mg or azelnidipine at 16 mg (ARB/CCB) or an ARB and hydrochlorothiazide (HCT) at 6.25 mg or 12. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3723
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http://dx.doi.org/10.14740/jocmr3723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396784PMC
March 2019
4 Reads

Human Papillomavirus Infection in Female Sex Workers: A Case Control Study.

J Clin Med Res 2019 Mar 13;11(3):196-201. Epub 2019 Feb 13.

Faculty of Medicine and Nutrition, Juarez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico.

Background: To determine the association of infection with human papillomavirus (HPV) and the occupation of female sex worker; and the correlation of infection with HPV with sociodemographic, clinical and behavioral characteristics of female sex workers.

Methods: We performed a case-control study of 217 female sex workers and 354 women without sex work in Durango City, Mexico. We determined the prevalence of infection with HPV in cervical samples of women using polymerase chain reaction, and HPV genotypes were determined using line probe assay. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3739
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http://dx.doi.org/10.14740/jocmr3739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396781PMC
March 2019
16 Reads

Preoperative Depressive Mood of Patients With Esophageal Cancer Might Delay Recovery From Operation-Related Malnutrition.

J Clin Med Res 2019 Mar 13;11(3):188-195. Epub 2019 Feb 13.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi, Abeno-ku, Osaka 545-8585, Japan.

Background: We investigated the relationship between the preoperative psychological state and the perioperative nutritional conditions of patients with esophageal cancer.

Methods: Seventy-three participants underwent operations for esophageal cancer in our hospital. Depressive state was evaluated using the Self-Rating Depression Scale (SDS). Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3704
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http://dx.doi.org/10.14740/jocmr3704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396782PMC
March 2019
4 Reads

Relationship of Salivary Occult Blood With General and Oral Health Status in Employees of a Japanese Department Store.

J Clin Med Res 2019 Mar 13;11(3):179-187. Epub 2019 Feb 13.

Department of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan.

Background: The Japanese Ministry of Health started screening for periodontal disease as part of senior health services in 1995. However, only a small number of workplaces conduct regular dental checkups in Japan. Therefore, the prevalence of periodontal disease and other oral health conditions has not been fully determined in workers in Japan. Read More

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http://dx.doi.org/10.14740/jocmr3702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396787PMC

Hyperbilirubinemia as a Predictor of Appendiceal Perforation: A Systematic Review and Diagnostic Test Meta-Analysis.

J Clin Med Res 2019 Mar 13;11(3):171-178. Epub 2019 Feb 13.

Department of General and Colorectal Surgery, Northampton General Hospital NHS Trust, Northampton, UK.

Background: Misdiagnosis of the severity of acute appendicitis may lead to perforation and can consequently result in increased morbidity and mortality. In this study, the role of hyperbilirubinemia as a predictor of perforation is assessed by performing a meta-analysis of diagnostic accuracy.

Methods: A systematic search of the literature published over the past 20 years was performed using the EMBASE, PubMed, Cochrane library, and Google Scholar databases. Read More

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http://dx.doi.org/10.14740/jocmr3724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396786PMC
March 2019
4 Reads

Association of Oral Function With Long-Term Participation in Community-Based Oral Exercise Programs in Older Japanese Women: A Cross-Sectional Study.

J Clin Med Res 2019 Mar 13;11(3):165-170. Epub 2019 Feb 13.

Department of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

Background: There are several researches demonstrating that community-based educational and exercise programs can improve oral function in older people. However, the relationship between oral function and long-term participation in health programs has not been fully elucidated. The objective of this study was to clarify the oral health status and oral function of older people (≥ 65 years) who had been participating in community-based exercise programs at community salons. Read More

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http://dx.doi.org/10.14740/jocmr3664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396783PMC

Status of Emergency Department Seventy-Two Hour Return Visits Among Homeless Patients.

J Clin Med Res 2019 Mar 13;11(3):157-164. Epub 2019 Feb 13.

Department of Emergency Medicine, Integrative Emergency Services, John Peter Smith Health Network, 1500 S. Main St., Fort Worth, TX 76104, USA.

Background: We aim to externally validate the status of emergency department (ED) appropriate utilization and 72-h ED returns among homeless patients.

Methods: This is a retrospective single-center observational study. Patients were divided into two groups (homeless versus non-homeless). Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3747
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http://dx.doi.org/10.14740/jocmr3747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396788PMC
March 2019
7 Reads

Does Metformin Assist New Anti-Diabetic Drugs to Succeed?

J Clin Med Res 2019 Feb 5;11(2):151-155. Epub 2019 Jan 5.

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.

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http://dx.doi.org/10.14740/jocmr3706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340680PMC
February 2019

Massive Hemoptysis Due to the Rupture of Thoracic Aortic Aneurysm Caused by Leukemic Cell Infiltration in a Patient With Chronic Myelomonocytic Leukemia.

J Clin Med Res 2019 Feb 5;11(2):145-150. Epub 2019 Jan 5.

Department of Clinical Pathology, Asahi General Hospital, Chiba, Japan.

Hemoptysis is occasionally experienced in patients with hematological malignancies who have respiratory tract infection and severe thrombocytopenia. Thrombocytopenia due to hematological disease is one cause of hemoptysis. Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy characterized by both a myeloproliferative neoplasm and a myelodysplastic syndrome. Read More

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http://dx.doi.org/10.14740/jocmr3712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340676PMC
February 2019
6 Reads

Factors Influencing the Results in Matrix-Associated Autologous Chondrocyte Implantation: A 2 - 5 Year Follow-Up Study.

J Clin Med Res 2019 Feb 5;11(2):137-144. Epub 2019 Jan 5.

Department of Orthopedics, Ankara Yildirim Beyazit University, Ankara, Turkey.

Background: This study aimed to investigate the outcomes of matrix-associated autologous chondrocyte implantation (MACI) on the treatment of osteochondral lesions in the knee joint and to determine the factors affecting the functional results.

Methods: The study included 34 patients with a cartilage defect in the knee joint who were applied MACI® (GenzymeBiosurgery, Cambridge, Massachusetts, USA) technique between the years 2010 - 2015. The defect localizations and sizes, past surgeries were recorded. Read More

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http://dx.doi.org/10.14740/jocmr3711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340672PMC
February 2019

The Gonadotropin-Releasing Hormone Analogue Therapy May Not Impact Final Height in Precocious Puberty of Girls With Onset of Puberty Aged 6 - 8 Years.

J Clin Med Res 2019 Feb 5;11(2):133-136. Epub 2019 Jan 5.

Department of Pediatric Endocrinology, School of Medicine, Ege University, Izmir, Turkey.

Background: The effect on final height of gonadotropin-releasing hormone analogues (GnRHa) used in the treatment of precocious puberty is controversial. The aim of this study was to determine whether or not GnRHa therapy would make any contribution to final height in precocious puberty of girls with onset of pubertal characteristic development aged 6 - 8 years.

Methods: Age at start of puberty, target height standard deviation score (SDS) presentation, follow-up height SDS, body mass index (BMI) SDS, bone age and predicted adult height of 34 female subjects who had reached their final height and with pubertal findings beginning at the ages of 6 - 8 were evaluated. Read More

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http://dx.doi.org/10.14740/jocmr3710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340673PMC
February 2019

Effect of Troponin I Elevation on Duration of Mechanical Ventilation and Length of Intensive Care Unit Stay in Patients With Sepsis.

J Clin Med Res 2019 Feb 5;11(2):127-132. Epub 2019 Jan 5.

University of Khartoum, Khartoum, Sudan.

Background: Sepsis is a leading cause of mortality and morbidity. Recent studies suggest that troponin elevation is associated with increased mortality in sepsis patients. The purpose of this study is to determine the effect of troponin elevation on mechanical ventilation duration and intensive care unit (ICU) length of stay in patients with sepsis. Read More

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http://dx.doi.org/10.14740/jocmr3713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340681PMC
February 2019
3 Reads

To Use or Not to Use Opioid Analgesia for Acute Abdominal Pain Before Definitive Surgical Diagnosis? A Systematic Review and Network Meta-Analysis.

J Clin Med Res 2019 Feb 5;11(2):121-126. Epub 2019 Jan 5.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TG, UK.

Background: Despite the existing evidence, many physicians are reluctant to use opioid analgesia for acute abdominal pain.

Methods: We performed updated conventional and network meta-analyses. For the first time to our knowledge, direct and indirect evidence of any type of opioid analgesia was estimated and compared using network meta-analysis. Read More

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http://dx.doi.org/10.14740/jocmr3690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340675PMC
February 2019

Assessment of Salivary Nitric Oxide Levels in Elite University Athletes in Japan: Findings From a Cross Sectional Study Design.

J Clin Med Res 2019 Feb 5;11(2):114-120. Epub 2019 Jan 5.

Faculty of Health and Sports Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.

Background: High-intensity exercise affects the level of salivary nitric oxide (NO) with an impact on oxidative stress such as a reactive nitrogen-oxide species. However, in athletes with high-intensity training, the relationship between salivary NO levels and oxidative stress is yet to be clear. Additionally, the association of salivary NO levels and the common health disorders of athletes is unknown. Read More

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http://dx.doi.org/10.14740/jocmr3670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340678PMC
February 2019

Bleeding Complications in Warfarin-Treated Patients Admitted to the Emergency Department.

J Clin Med Res 2019 Feb 5;11(2):106-113. Epub 2019 Jan 5.

Department of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.

Background: Increased use of warfarin for the treatment and prophylaxis of many diseases has increased the frequency of adverse events. Emergency departments (EDs) are the first places where early interventions for bleeding and other complaints related to warfarin use are performed. This study assessed the characteristics of patients receiving warfarin and the risk factors for bleeding complication among those admitted to the ED. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3669
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http://dx.doi.org/10.14740/jocmr3669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340679PMC
February 2019
8 Reads

Cytoskeletal Tropomyosin as a Biomarker in Infection.

J Clin Med Res 2019 Feb 5;11(2):98-105. Epub 2019 Jan 5.

Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Background: Current diagnostics of infection (CDI) heavily relies on detection of the disease-causing organism. The objective of this study was to investigate a cytoskeletal protein, tropomyosin (Tpm), as a CDI biomarker.

Methods: Fecal Tpm was tested by monoclonal antibodies (mAbs) in a 12-month prospective study. Read More

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http://dx.doi.org/10.14740/jocmr3696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340674PMC
February 2019
2 Reads

Investigation of a Dipeptidyl Peptidase-4 Inhibitor/Thiazolidinedione Combination Drug for Patients With Type 2 Diabetes and Poor Glycemic Control: Difficulty With Patient Enrollment.

J Clin Med Res 2019 Feb 5;11(2):89-97. Epub 2019 Jan 5.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Chikushino, Japan.

Background: One of the treatment options for type 2 diabetes mellitus (DM) is a combination drug (CD) that contains the dipeptidyl peptidase-4 inhibitor (DPP4I) alogliptin (AG) together with pioglitazone (PG). This CD can improve impaired insulin secretion and insulin resistance, which are the two major pathologic factors for type 2 DM, and is also expected to increase adherence to treatment. We conducted a multicenter open-label prospective study to examine the usefulness of this CD for routine management of type 2 DM. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3558
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http://dx.doi.org/10.14740/jocmr3558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340677PMC
February 2019
9 Reads

Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.

J Clin Med Res 2019 Feb 5;11(2):81-88. Epub 2019 Jan 5.

Department of Gastroenterology and Hepatology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.

Primary sclerosing cholangitis (PSC) is a chronic and progressive disease of the biliary tract. PSC is strongly associated with inflammatory bowel disease (IBD), mainly with ulcerative colitis, and most PSC patients have underlying IBD. The pathophysiological interactions between IBD and PSC are unclear, although it seems that the patients with IBD and PSC have a distinct phenotype. Read More

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http://dx.doi.org/10.14740/jocmr3680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340671PMC
February 2019
2 Reads

An Effective Insulin Therapy in Combination With Sodium-Glucose Cotransporter 2 Inhibitors.

J Clin Med Res 2019 Jan 3;11(1):76-79. Epub 2018 Dec 3.

Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.

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http://dx.doi.org/10.14740/jocmr3676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306135PMC
January 2019
1 Read

Persistent Primitive Hypoglossal Artery Associated With Multiple Cerebral Aneurysms.

J Clin Med Res 2019 Jan 3;11(1):72-75. Epub 2018 Dec 3.

Department of Neurosurgery, Kanto Rosai Hospital, Kawasaki, Japan.

Persistent primitive hypoglossal artery is a rare anastomosis between the carotid and basilar arteries, and sometimes associated with cerebral aneurysms. However, association of persistent primitive hypoglossal artery with aneurysms located on arteries other than persistent primitive hypoglossal artery itself or posterior circulation is very rare. An 80-year-old woman suffered from subarachnoid hemorrhage, whose angiography demonstrated aneurysms on the left middle cerebral artery and anterior communicating artery, and the left persistent primitive hypoglossal artery. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3649
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http://dx.doi.org/10.14740/jocmr3649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306131PMC
January 2019
13 Reads

The Role of Exercise in the Quality of Life in Patients After Pancreatectomy: A Prospective Randomized Controlled Trial.

J Clin Med Res 2019 Jan 3;11(1):65-71. Epub 2018 Dec 3.

School of Physical Education and Sports Sciences at Serres, "Aristotle" University, Thessaloniki, Greece.

Background: Pancreatic resection is still a challenging operation characterised by high morbidity. The quality of life in patients after pancreatectomy is a critical outcome. The aim of our trial is to prove whether or not exercise has any benefit to the life of these patients. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3675
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http://dx.doi.org/10.14740/jocmr3675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306133PMC
January 2019
14 Reads

Acute Appendicectomy or Conservative Treatment for Complicated Appendicitis (Phlegmon or Abscess)? A Systematic Review by Updated Traditional and Cumulative Meta-Analysis.

J Clin Med Res 2019 Jan 3;11(1):56-64. Epub 2018 Dec 3.

Department of Colorectal Surgery, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

Background: The existing evidence on the treatment of complicated appendicitis favors conservative treatment rather than acute appendicectomy. Update traditional meta-analysis and consequently cumulative meta-analysis was performed to track the accumulation of evidence over time.

Methods: Studies were identified by a systematic literature search of the EMBASE, PubMed, Cochrane Library and Google Scholar databases. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3672
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http://dx.doi.org/10.14740/jocmr3672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306138PMC
January 2019
20 Reads

Renoprotective Benefit of Tolvaptan in Acute Decompensated Heart Failure Patients With Loop Diuretic-Resistant Status.

J Clin Med Res 2019 Jan 3;11(1):49-55. Epub 2018 Dec 3.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyouin, Chikushino, Fukuoka 818-8502, Japan.

Background: While reduction of accumulated body fluid using loop diuretics is a commonly used therapeutic option for acute heart failure (AHF), some patients, especially those with chronic kidney disease (CKD), show significantly poor treatment response to loop diuretics. Tolvaptan (TLV) has shown effectiveness against AHF in several studies. We have been using TLV for AHF treatment, and it displayed favorable outcome even in patients with CKD. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3671
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http://dx.doi.org/10.14740/jocmr3671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306139PMC
January 2019
9 Reads

Gastrointestinal Bleeding in Patients With Acute Respiratory Distress Syndrome: A National Database Analysis.

J Clin Med Res 2019 Jan 3;11(1):42-48. Epub 2018 Dec 3.

Department of Pulmonary & Critical Care, Staten Island University Hospital, Northwell Health, NY, USA.

Background: The goal of our study was to determine the impact of gastrointestinal bleeding (GIB) on in-hospital outcomes among acute respiratory distress syndrome (ARDS) patients, and subsequently determine the potential risk factors for the development of GIB.

Methods: ARDS patients with and without GIB were identified using the National Inpatient Sample (2002 - 2012). Linear regression analysis was used to assess impact of GIB on in-hospital mortality, length of stay and total charges. Read More

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http://dx.doi.org/10.14740/jocmr3660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306132PMC
January 2019
9 Reads

Residual Effect of Sodium Glucose Cotransporter 2 Inhibitor, Tofogliflozin, on Body Weight After Washout in Japanese Men With Type 2 Diabetes.

J Clin Med Res 2019 Jan 3;11(1):35-41. Epub 2018 Dec 3.

Kanazawa Medical University, Ishikawa, Japan.

Background: We investigated the potential mechanism underlying body weight reduction by the sodium glucose cotransporter 2 (SGLT2) inhibitor, tofogliflozin, during treatment and after subsequent washout.

Methods: Ten Japanese men with type 2 diabetes (average age: 66.3 years) were orally administered tofogliflozin (20 mg/day) for 8 weeks followed by a subsequent 8-week washout period (16 weeks). Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3650
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http://dx.doi.org/10.14740/jocmr3650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306130PMC
January 2019
2 Reads

Alcohol Withdrawal: Possible Risk of Latent Scurvy Appearing as Tiredness: A STROBE-Compliant Study.

J Clin Med Res 2019 Jan 3;11(1):26-34. Epub 2018 Dec 3.

Nouvelle Clinique des Trois Frontieres, 8, rue Saint Damien 68300 Saint-Louis, France.

Background: Little is known about the prevalence of vitamin C deficiency in the population of individuals who are withdrawing from alcohol, and about possible consequences of latent scurvy. The aim of this study was to evaluate the prevalence of vitamin C deficiency in patients who were withdrawing from alcohol, its correlation with latent scurvy (mainly tiredness and weakness) and the change in the latter symptoms at 3 months after oral vitamin C supplementation.

Methods: A total of 47 patients (33 males, 14 females) who volunteered to undertake alcohol detoxification were included prospectively between January 2014 and November 2016. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3643
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http://dx.doi.org/10.14740/jocmr3643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306134PMC
January 2019
14 Reads

Obstructive Sleep Apnea Screening in Patients With Atrial Fibrillation: Missed Opportunities for Early Diagnosis.

J Clin Med Res 2019 Jan 3;11(1):21-25. Epub 2018 Dec 3.

Department of Internal Medicine, Staten Island University Hospital Staten Island, 475 Seaview Ave, Staten Island, NY 10305, USA.

Background: "There is a high prevalence of obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF). There is also strong evidence that proper OSA management can reduce AF recurrence." Polysomnography is the gold standard for OSA diagnosis, but screening tests, such as STOP-BANG, have been successful in identifying patients at risk for OSA. Read More

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http://dx.doi.org/10.14740/jocmr3635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306129PMC
January 2019
3 Reads

Effects of Sitagliptin on Pancreatic Beta-Cells in Type 2 Diabetes With Sulfonylurea Treatment: A Prospective Randomized Study.

J Clin Med Res 2019 Jan 3;11(1):15-20. Epub 2018 Dec 3.

Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Background: This prospective randomized, multicenter, open-label, comparative study was performed to analyze the effects of sitagliptin on glycemic control and maintenance of beta-cell function in patients with poorly controlled type 2 diabetes treated with low-dose glimepiride.

Methods: Forty-one patients with type 2 diabetes mellitus treated with low-dose glimepiride (≤ 2 mg/day) were prospectively enrolled in this study (age: 20 - 75 years; hemoglobin A1c (HbA1c): 7.4- 9. Read More

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http://dx.doi.org/10.14740/jocmr3632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306137PMC
January 2019
8 Reads

Quality Improvement in Ambulatory Surgery Centers: A Major National Effort Aimed at Reducing Infections and Other Surgical Complications.

J Clin Med Res 2019 Jan 3;11(1):7-14. Epub 2018 Dec 3.

Ariadne Labs, A Joint Center Between Brigham and Women's Hospital and the Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: Surgical volume has shifted significantly from inpatient to outpatient settings, including free-standing ambulatory surgery centers (ASCs). Approaches to quality improvement (QI) and surveillance used in hospitals are not always appropriate to the ambulatory setting.

Methods: We recruited 665 ASCs in 47 US states to participate in an intervention to improve safe practice through implementation of a surgical safety checklist and infection control practices. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3603
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http://dx.doi.org/10.14740/jocmr3603wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306128PMC
January 2019
9 Reads

Risk Factors Associated With Recurrent Infection.

J Clin Med Res 2019 Jan 3;11(1):1-6. Epub 2018 Dec 3.

Department of Internal Medicine at Cooper University Hospital, 1103 North Kings Highway Suite 203, Cherry Hill, NJ 08034, USA.

Background: Recurrence of infection (CDI) is a problem that can cost up to $20,000 each year in the United States. Studies have reported risk factors that may be associated with a higher incidence of recurrent CDI. We studied additional risk factors, including history of partial colectomy, chemotherapy use and hospitalization in the intensive care unit (ICU). Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3531
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http://dx.doi.org/10.14740/jocmr3531wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306136PMC
January 2019
11 Reads

Which Nutritional Factors Are Good for HDL?

J Clin Med Res 2018 Dec 30;10(12):936-939. Epub 2018 Oct 30.

The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.14740/jocmr3646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225857PMC
December 2018
1 Read

Clinical Impact of Hemorheology on Subclinical Myocardial Injury in Patients with Hypertension.

J Clin Med Res 2018 Dec 30;10(12):928-935. Epub 2018 Oct 30.

Hitsumoto Medical Clinic, Yamaguchi, Japan.

Background: The blood concentration of high-sensitivity cardiac troponin T (hs-cTnT) is a useful biomarker for myocardial injury or the pathogenesis of hypertension. Little is known about the relationship between hemorheology and myocardial injury in patients with hypertension. This cross-sectional study aimed to clarify the clinical impact of hemorheology on subclinical myocardial injury assessed with a microchannel array flow analyzer (MC-FAN) and its impact on hs-cTnT in patients with hypertension. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3652
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http://dx.doi.org/10.14740/jocmr3652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225855PMC
December 2018
12 Reads

Relationship Between Sarcopenia and Both Physical Activity and Lifestyle in Patients With Chronic Liver Disease.

J Clin Med Res 2018 Dec 30;10(12):920-927. Epub 2018 Oct 30.

Department of Nursing, Niigata University Graduate School of Health Sciences, Niigata, Japan.

Background: Sarcopenia can affect the prognosis of patients with cirrhosis or hepatocellular carcinoma. Exercise therapy and nutritional therapy are carried out to prevent processing sarcopenia. In addition, changing lifestyle is also important. Read More

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http://www.jocmr.org/index.php/JOCMR/article/view/3640
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http://dx.doi.org/10.14740/jocmr3640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225858PMC
December 2018
24 Reads

Comparison of Comorbid Conditions Between Cancer Survivors and Age-Matched Patients Without Cancer.

J Clin Med Res 2018 Dec 30;10(12):911-919. Epub 2018 Oct 30.

Cooper Research Institute, Cooper Medical School of Rowan University, Camden, NJ, USA.

Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer.

Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Read More

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http://dx.doi.org/10.14740/jocmr3617wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225860PMC
December 2018
12 Reads