8,026 results match your criteria Journal of clinical gastroenterology[Journal]


Chronic Obstructive Pulmonary Disease and the Risk of Esophagitis, Barrett Esophagus, and Esophageal Adenocarcinoma: A Primary Care Case-Control Study.

J Clin Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Sandwell General Hospital, West Bromwich, UK.

Background: Chronic gastroesophageal reflux predisposes to the development of esophageal adenocarcinoma (EAC). Asthma and medication to treat it are associated with gastroesophageal reflux and EAC. We studied subjects with chronic obstructive pulmonary disease (COPD) to examine the relationship between COPD and medication used to treat it, and the risk of reflux esophagitis, Barrett esophagus, and EAC. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001215DOI Listing

Thromboelastography-guided Blood Product Transfusion in Cirrhosis Patients With Variceal Bleeding: A Randomized Controlled Trial.

J Clin Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Goals: The aim of this study was to assess the use of thromboelastography (TEG)-directed blood product transfusion in cirrhotic patients with acute variceal bleeding compared with conventional transfusion for correction of coagulopathy.

Background: Coagulopathy is common in patients with cirrhosis. Recommendations for correction of conventional parameters of coagulation-platelets and the international normalized ratio before endoscopy in patients with acute variceal bleeding-need more validation. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001214DOI Listing

Race/Ethnicity-specific Disparities in In-Hospital Mortality and Hospital Charges Among Inflammatory Bowel Disease-related Hospitalizations in the United States.

J Clin Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology and Hepatology, Alameda Health System, Highland Hospital, Oakland, CA.

Goal: The goal of this study was to evaluate disparities in hospital outcomes among inflammatory bowel disease (IBD) related hospitalizations in the United States with a focus on ethnicity-specific disparities.

Background: IBD-related hospitalizations contribute to significant morbidity and health care economic burden.

Methods: IBD-related hospitalizations (identified with ICD-9) among US adults were evaluated using 2007 to 2013 Nationwide Inpatient Sample. Read More

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http://Insights.ovid.com/crossref?an=00004836-900000000-9773
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http://dx.doi.org/10.1097/MCG.0000000000001204DOI Listing
April 2019
1 Read

Fecal Lactoferrin for Assessment of Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China.

Objective: Persistent disease activity is associated with a poor prognosis in inflammatory bowel disease (IBD) patients. Therefore, monitoring of IBD activity can avoid the poor prognosis. Serum biomarkers reflect a summation of systemic host responses rather than being specific for intestinal inflammation. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001212DOI Listing

Predictors of Gastrin Elevation Following Proton Pump Inhibitor Therapy.

J Clin Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Department of Internal Medicine, Division of Gastroenterology, Landspitali-The National University Hospital of Iceland.

Goals: The goal of this study was to elucidate the most important predictors for elevation of gastrin in patients on long-term PPI therapy through analysis of data from 2 published studies in Icelandic patients with erosive GERD.

Background: Gastrin elevation is a known but variable consequence of proton pump inhibitor (PPI) therapy. Concerns have been raised about the clinical importance of chronic PPI induced gastrin elevation. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001200DOI Listing
April 2019
1 Read

Impact of Automated Time-released Reminders on Patient Preparedness for Colonoscopy.

J Clin Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Division of Gastroenterology, Hepatology and Endoscopy.

Goals: To evaluate the effect of an automated time-released colonoscopy reminder program on preparation quality and the rates of canceled procedures.

Background: Patients missing colonoscopy appointments or arriving with inadequate bowel preparations result in delays in care and increase in health care costs.

Study: We initiated a quality improvement program which included switching to a split-dose preparation and delivering preparation instructions and appointment reminders via text messages and emails sent with an automated time-released HIPAA-compliant software platform. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001211DOI Listing
April 2019
1 Read

World Gastroenterology Organisation (WGO) News and Events.

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J Clin Gastroenterol 2019 May/Jun;53(5):1-2

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http://dx.doi.org/10.1097/MCG.0000000000001210DOI Listing

Incidence and Risk Factors Associated With 30-Day Readmission for Alcoholic Hepatitis.

J Clin Gastroenterol 2019 Apr 3. Epub 2019 Apr 3.

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester.

Background: Alcohol abuse and liver disease are associated with high rates of 30-day hospital readmission, but factors linking alcoholic hepatitis (AH) to readmission are not well understood. We aimed to determine the incidence rate of 30-day readmission for patients with AH and to evaluate potential predictors of readmission.

Methods: We used the Nationwide Readmissions Database to determine the 30-day readmission rate for recurrent AH between 2010 and 2014 and examined trends in readmissions during the study period. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001202DOI Listing
April 2019
2 Reads
3.498 Impact Factor

Older Adult Perspectives Toward Surveillance Colonoscopy: A Qualitative Study.

J Clin Gastroenterol 2019 Apr 3. Epub 2019 Apr 3.

Center for Program Design & Evaluation, Dartmouth Geisel School of Medicine, Hanover, NH.

Goals And Background: Surveillance colonoscopy is the most common indication for colonoscopy in older adults, yet factors involved in patient decision-making are poorly defined. We sought to understand general perspectives of older adults toward surveillance colonoscopy.

Study: We conducted 2 in-person, 90-minute semistructured focus groups at a rural, tertiary care, academic facility with a total of 20 English-speaking participants with a history of colon polyps. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001203DOI Listing
April 2019
6 Reads

Duodenal Biopsy Rate Differences Among Endoscopists and its Impact on Celiac Disease Diagnosis and Management.

J Clin Gastroenterol 2019 Apr 3. Epub 2019 Apr 3.

Gastroenterology Department, Buenos Aires British Hospital Buenos Aires, Argentina.

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http://dx.doi.org/10.1097/MCG.0000000000001208DOI Listing

Supplementary Sorafenib Therapies for Hepatocellular Carcinoma-A Systematic Review and Meta-Analysis: Supplementary Sorafenib for Liver Cancer.

J Clin Gastroenterol 2019 Apr 1. Epub 2019 Apr 1.

Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan.

Background: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Sorafenib is considered a supplementary treatment to surgical or locoregional therapies for improving outcomes. We evaluated the efficacy of sorafenib as a supplementary therapy for HCC. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001175DOI Listing
April 2019
2 Reads
3.498 Impact Factor

Letter to the Editor Concerning "Lumen Apposing Metal Stents (LAMSs) for Drainage of Pancreatic and Gallbladder Collections: A Meta-analysis".

J Clin Gastroenterol 2019 Apr 1. Epub 2019 Apr 1.

Department of Gastroenterology, Affiliated Hospital of Southwest Medical University Luzhou, China.

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http://dx.doi.org/10.1097/MCG.0000000000001209DOI Listing

High-resolution Manometry can Characterize Esophagogastric Junction Morphology and Predict Esophageal Reflux Burden.

J Clin Gastroenterol 2019 Apr 1. Epub 2019 Apr 1.

Division of Gastroenterology, Washington University School of Medicine, Saint Louis, MO.

Background: High-resolution manometry (HRM) allows characterization of esophagogastric junction (EGJ) morphology and identification of hiatus hernia using novel software tools.

Aim: The main purpose of this study was to determine the impact of HRM-based EGJ and lower esophageal sphincter (LES) metrics in predicting abnormal reflux burden.

Methods: Total, upright, and supine acid exposure times (AETs) were extracted from ambulatory reflux monitoring performed off therapy in 482 patients (54. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001205DOI Listing

Evaluation of Esophageal Contraction Reserve Using HRM in Symptomatic Esophageal Disease.

J Clin Gastroenterol 2019 May/Jun;53(5):322-330

Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO.

Esophageal high resolution manometry (HRM) is the gold standard for assessment of esophageal motor disorders, but motor responses to the standard 5 mL water swallow protocol may not provide precision in defining minor motor disorders. Provocative maneuvers, particularly multiple rapid swallows (MRS), have been used to assess deglutitive inhibition during the repetitive swallows, and the contractile response following the final swallow of the sequence. The augmentation of esophageal smooth muscle contraction following MRS is termed contraction reserve. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001206DOI Listing

Smoking and the Increased Risk for Serrated Polyps: Implications for Screening and Surveillance.

J Clin Gastroenterol 2019 May/Jun;53(5):319-321

Stony Brook University, Stony Brook, NY.

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http://dx.doi.org/10.1097/MCG.0000000000001207DOI Listing

Risk of Stroke in Liver Cirrhosis: A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2019 Mar 13. Epub 2019 Mar 13.

Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang.

Background And Aims: Liver cirrhosis can lead to abnormal coagulation, rendering patients at risk for bleeding but also thrombotic complications. We conducted a systematic review and meta-analysis to explore the epidemiology of stroke in liver cirrhosis and the potential association between them.

Materials And Methods: Studies were searched through the PubMed, EMBASE, and Cochrane Library databases. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001201DOI Listing
March 2019
1 Read

Risk Factors for Gastrointestinal Symptoms Following Successful Eradication of Clostridium difficile by Fecal Microbiota Transplantation (FMT).

J Clin Gastroenterol 2019 Mar 13. Epub 2019 Mar 13.

Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital.

Background: Fecal microbiota transplantation (FMT) is a promising therapy for recurrent Clostridioides difficile infection (CDI). Many patients report altered bowel habits including constipation, bloating, gas and loose stool post-FMT despite resolution of CDI, and the etiology remains unclear.

Methods: This was a prospective cohort study of adult patients with recurrent CDI who underwent FMT (1) via colonoscopy with patient-selected donor stool, (2) via colonoscopy from a universal stool bank donor, or (3) via capsules from a universal stool bank. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001194DOI Listing
March 2019
9 Reads

World Gastroenterology Organisation (WGO) News and Events.

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J Clin Gastroenterol 2019 Apr;53(4):1-2

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http://dx.doi.org/10.1097/MCG.0000000000001197DOI Listing

The Significance of a Pale Area Via Flexible Spectral Imaging Color Enhancement in the Diagnosis of Esophageal Precancerous Lesions and Early-stage Squamous Cancer.

J Clin Gastroenterol 2019 Feb 27. Epub 2019 Feb 27.

Department of Gastroenterology.

Goals: The main aim of this study was to investigate the significance of a pale area via flexible spectral imaging color enhancement (FICE) in the diagnosis of esophageal dysplasia and cancer.

Background: The early diagnosis of esophageal squamous cancer is challenging, and the indication of Lugol's chromoendoscopy has not yet been well established.

Study: The esophageal mucosa of patients at our endoscopic center were sequentially evaluated with white-light endoscopy and FICE during insertion of the endoscope, followed by staining with Lugol's solution during withdrawal. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001191DOI Listing
February 2019
3 Reads
3.498 Impact Factor

Lower 90-day Hospital Readmission Rates for Esophageal Variceal Bleeding After TIPS: A Nationwide Linked Analysis.

J Clin Gastroenterol 2019 Feb 27. Epub 2019 Feb 27.

Department of Medicine, Division of Gastroenterology, London Health Sciences Center.

Objective: Hospital readmission rates following a transjugular intrahepatic portosystemic shunt (TIPS) insertion after an episode of esophageal variceal bleeding (EVB) has not been well studied. We aimed to address this gap in knowledge on a population level.

Methods: The Nationwide Readmission Database (NRD) was used to study the readmission rates for patients with decompensated cirrhosis who had a TIPS insertion performed for EVB. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001199DOI Listing
February 2019
4 Reads

Does Helicobacter pylori Eradication Reduce the Incidence of Metachronous Gastric Cancer After Curative Endoscopic Resection of Early Gastric Cancer: A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2019 Feb 27. Epub 2019 Feb 27.

Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Heping District, Shenyang, P.R. China.

Background: Whether Helicobacter pylori eradication could reduce the risk of metachronous gastric cancer remain controversial. In the present study, we performed a systematic review and meta-analysis to evaluate the preventive effect of H. pylori eradication on the occurrence of metachronous gastric cancer after curative endoscopic resection of early gastric cancer. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001195DOI Listing
February 2019
11 Reads

Efficacy of Different Endoscopic Stents in the Management of Postoperative Biliary Strictures: A Systematic Review and Meta-analysis.

J Clin Gastroenterol 2019 Feb 22. Epub 2019 Feb 22.

Departments of Gastroenterology and Hepatology.

Background: Endoscopic stents are the first-line treatment in the management of benign biliary stricture (BBS) which include multiple plastic stents (MPSs), fully covered self-expandable metal stents (FCSEMS) including the conventional and modified ones (FCSEMS-C and FCSEMS-M) and biodegradable stents. However, different stents have their distinct advantages and disadvantages. We aim to conduct this systematic review to compare the efficacy of different stents in the management of BBS. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001193DOI Listing
February 2019
2 Reads

Gamma-Delta T lymphocytes in the Diagnostic Approach of Celiac Disease.

J Clin Gastroenterol 2019 Feb 22. Epub 2019 Feb 22.

Department of Gastroenterology, Hospital Universitari Mutua Terrassa, and Center for Biomedical Research in the Network (CIBER) of Hepatic and Digestive Diseases Terrassa (Barcelona), Spain.

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http://dx.doi.org/10.1097/MCG.0000000000001196DOI Listing
February 2019
1 Read

Surveying ADR Knowledge and Practices Among US Gastroenterologists.

J Clin Gastroenterol 2019 Feb 22. Epub 2019 Feb 22.

Department of Medicine, Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, IN.

Background: The adenoma detection rate (ADR) is of primary importance to the quality of screening colonoscopy. An online survey was conducted to assess knowledge and practices on ADR.

Methods: Paid questionnaire distributed by email. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001188DOI Listing
February 2019

Role of Interventional Radiology in Complications of Portal Hypertension.

J Clin Gastroenterol 2019 May/Jun;53(5):342-349

Department of Radiology, Division of Interventional Radiology.

Portal hypertension, a consequence of end-stage liver disease and liver cirrhosis can lead to significant morbidity and mortality for patients through abnormal fluid accumulation as well as the formation of portosystemic shunts and varices. Treatment of the sequelae of portal hypertension can be achieved through endovascular management by referral to an interventional radiologist on an outpatient or emergent basis as required. Current techniques include the placement of peritoneovenous shunts and tunneled peritoneal drains, the creation of transjugular intrahepatic portosystemic shunts, or the obliteration of shunts via balloon-occluded retrograde transvenous obliteration (BRTO). Read More

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http://dx.doi.org/10.1097/MCG.0000000000001180DOI Listing
February 2019
1 Read
3.498 Impact Factor

Gender Differences Among Patients Hospitalized With Cirrhosis in the United States.

J Clin Gastroenterol 2019 Feb 22. Epub 2019 Feb 22.

Department of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco.

Background And Aims: Gender disparities exist in outcomes among patients with cirrhosis. We sought to evaluate the role of gender on hospital course and in-hospital outcomes in patients with cirrhosis to help better understand these disparities.

Study: We analyzed data from the National Inpatient Sample (NIS), years 2009 to 2013, to identify patients with any diagnosis of cirrhosis. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001192DOI Listing
February 2019
4 Reads

Ilaprazole Compared With Rabeprazole in the Treatment of Duodenal Ulcer: A Randomized, Double-blind, Active-controlled, Multicenter Study.

J Clin Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Livzon Pharmaceutical Group Inc., Zhuhai, Guangdong, China.

Goals: The main goal of this study was to explore the dose-effect relationship of ilaprazole.

Background: Ilaprazole is a kind of benzimidazole proton-pump inhibitor, which was confirmed efficacious and safe in treatment of duodenal ulcer (DU). However, the dose-effect relationship of ilaprazole was not clear. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001186DOI Listing
February 2019
3 Reads

Antioxidants for Pancreatic Functions in Chronic Pancreatitis: A Double-blind Randomized Placebo-controlled Pilot Study.

J Clin Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Gastroenterology and Human Nutrition Unit.

Background: Antioxidants (AO) supplementation in chronic pancreatitis (CP) has been evaluated for pain. But it is not clear whether AO in CP have an effect on pancreatic functions and other clinical outcomes. We evaluated effect of AO on endocrine function in CP. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001178DOI Listing
February 2019

Poor Health Literacy and Medication Burden Are Significant Predictors for Inadequate Bowel Preparation in an Urban Tertiary Care Setting.

J Clin Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD.

Goals: The goal of this study was to identify factors impacting the quality of bowel preparation in an urban tertiary care setting.

Background: Inadequate bowel preparation is encountered in 17% to 32% of colonoscopies performed in the United States. Suboptimal colonic visualization reduces the yield of screening colonoscopies and increases healthcare costs because of longer procedure times and aborted procedures. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001177DOI Listing
February 2019

Has Increased Rollout of Direct Acting Antiviral Therapy Decreased the Burden of Late Presentation and Advanced Liver Disease in Patients Starting Hepatitis C Virus Therapy in Germany?

J Clin Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine I, University Hospital Bonn, Bonn.

Goals And Background: International guidelines recommend prioritized treatment initiation in hepatitis C virus (HCV)-infected patients with advanced liver disease. We aimed to evaluate whether the widespread usage of direct acting antivirals (DAAs) has led to a decrease in late presentation for care.

Study: Data derived from the multicenter German Hepatitis C Cohort (GECCO) was analyzed. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001189DOI Listing
February 2019

More Severe Deficits in Performance Status at Time of Liver Transplant is Associated With Significantly Higher Risk of Death Following Liver Transplantation.

J Clin Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology and Hepatology, Alameda Health System, Highland Hospital, Oakland, CA.

Goal: To evaluate the impact of Karnofsky Performance Status score (KPSS) at the time of liver transplantation (LT) on post-LT survival.

Background: While the Model for End-Stage Liver Disease (MELD) score is used to prioritize individuals for LT, it does not specifically incorporate functional status into patient assessment for LT.

Methods: Using 2005 to 2016 United Network for Organ Sharing data, all adults (age 18 y and above) undergoing LT were identified. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001187DOI Listing
February 2019
3.498 Impact Factor

Reflux Symptoms in Gastroparesis: Correlation With Gastroparesis Symptoms, Gastric Emptying, and Esophageal Function Testing.

J Clin Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA.

Goal: The goal of this study was to determine the relationship of reflux with gastroparesis (Gp), looking both at symptoms and objective testing.

Background: Gp patients often experience gastroesophageal reflux symptoms. How the severity of reflux correlates with the severity of Gp is not known. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001190DOI Listing
February 2019
2 Reads

World Gastroenterology Organisation (WGO) News and Events.

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J Clin Gastroenterol 2019 Mar;53(3):1-2

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http://dx.doi.org/10.1097/MCG.0000000000001176DOI Listing
March 2019
5 Reads

Thirty Years of Lactobacillus rhamnosus GG: A Review.

Authors:
Lucio Capurso

J Clin Gastroenterol 2019 Mar;53 Suppl 1:S1-S41

Department of Gastroenterology, San Filippo Neri Hospital, Rome, Italy.

Lactobacillus rhamnosus GG (LGG) was the first strain belonging to the genus Lactobacillus to be patented in 1989 thanks to its ability to survive and to proliferate at gastric acid pH and in medium containing bile, and to adhere to enterocytes. Furthermore LGG is able to produces both a biofilm that can mechanically protect the mucosa, and different soluble factors beneficial to the gut by enhancing intestinal crypt survival, diminishing apoptosis of the intestinal epithelium, and preserving cytoskeletal integrity. Moreover LGG thanks to its lectin-like protein 1 and 2 inhibits some pathogens such as Salmonella species. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001170DOI Listing
March 2019
7 Reads

Conditioned Pain Modulation (CPM) is Reduced in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of CPM and the Role of Psychological Factors.

J Clin Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Pain Management Research Institute, Faculty of Medicine and Health.

This systematic review summarises evidence assessing endogenous pain inhibition in people with irritable bowel syndrome (IBS) compared with healthy controls using conditioned pain modulation (CPM) and offset analgesia (OA). Evidence regarding the role of psychological variables is also examined. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001181DOI Listing
February 2019
2 Reads

Transcutaneous Neuromodulation at ST36 (Zusanli) is More Effective than Transcutaneous Tibial Nerve Stimulation in Treating Constipation.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Ningbo Pace Translational Medical Research Center, Beilun.

Background And Goals: Combined transcutaneous neuromodulation (TN) at acupoint ST36 (Zusanli) and TN at the posterior tibial nerve (PTN) has been reported effective in treating functional constipation. This study was designed to compare the effectiveness of TN between these 2 points.

Materials And Methods: Eighteen functional constipation patients (M/F: 9/9) were recruited to participate in a cross-over study with a 2-week TN at ST36 and a 2-week TN at PTN. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001184DOI Listing
February 2019
1 Read
3.498 Impact Factor

Noninvasive Assessment of Portal Hypertension Using Spectral Computed Tomography.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Department of Oncology Interventional Therapy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, China.

Background: Early diagnosis of portal hypertension is imperative for timely treatment to reduce the mortality rate. However, there is still no adequate method to noninvasively and accurately assess the portal hypertension in routine clinical practice.

Purpose: We aimed to evaluate the accuracy of parameters measured using dual energy spectral computed tomography (LightSpeed CT750 HD) in assessing portal venous pressure in patients with liver cirrhosis. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001185DOI Listing
February 2019
2 Reads

Effect of Chronic Domperidone Use on QT Interval: A Large Single Center Study.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Section of Gastroenterology, Department of Medicine, University of Florida Jacksonville, Jacksonville, FL.

Goals: The goal of this study was to determine the effect and safety of domperidone on QTc interval at the commonly prescribed doses of 30 to 80 mg daily.

Background: Domperidone is a dopamine receptor antagonist used for the treatment of gastroparesis. However, it has been associated with QT prolongation, ventricular arrhythmias, and sudden cardiac death. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001183DOI Listing
February 2019
2 Reads

An Intraprocedural Endoscopic Cleansing Device for Achieving Adequate Colon Preparation in Poorly Prepped Patients.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Carmel Medical Center, Haifa, Israel.

Background And Aims: An effective bowel preparation is essential for quality colonoscopy. Inadequate preparation results in missed lesions, need for earlier repeat procedures, prolonged colonoscopy duration, an increased likelihood of adverse events, reduced patient satisfaction, and increased costs. The MOTUS GI Pure-Vu System (Tirat Carmel, Israel) is an Food and Drug Administration-cleared device designed to improve visualization in an inadequately prepared colon by facilitating intraprocedural cleaning. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001114DOI Listing
February 2019

GI Motility Testing: Stomach, Small Bowel, and Colon.

J Clin Gastroenterol 2019 Mar;53(3):159-169

Division of Gastroenterology, University of Michigan, Ann Arbor, MI.

Symptoms of abdominal pain, nausea, vomiting, bloating, abdominal distention, diarrhea, and constipation are common and may relate to abnormalities in gastrointestinal motility. There are a number of different options to study gastrointestinal motility. This article reviews novel and standard motility tests available in the stomach, small bowel, and colon. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001138DOI Listing
March 2019
1 Read

A Comprehensive Review of Patient-reported Outcomes in Patients With Chronic Liver Diseases.

J Clin Gastroenterol 2019 May/Jun;53(5):331-341

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA.

Chronic liver disease (CLD) is a global health problem with chronic viral hepatitis, alcohol-related liver disease, and nonalcoholic fatty liver disease being important causes of mortality. Besides its clinical burden, patients with CLD also suffer from impairment of their health-related quality of life and other patient-reported outcomes (PRO). In this context, a combination of both clinical and PROs will allow assessment of the comprehensive burden of liver disease on patients. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001179DOI Listing
February 2019
1 Read

POEM in Latin America: The Rise of a New Standard.

J Clin Gastroenterol 2019 Jan 29. Epub 2019 Jan 29.

Gastrointestinal Endoscopy Unit, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Background: Per-oral endoscopic myotomy (POEM) has become the preferred alternative treatment to standard Heller myotomy for patients with esophageal achalasia, in Latin American countries. The aim of our study was to evaluate the efficacy and safety of a POEM in the management of achalasia with and without Chagas disease in patients receiving POEM.

Methods: Patients who underwent POEM from tertiary centers in Latin America were included in a dedicated registry. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001161DOI Listing
January 2019
12 Reads
3.498 Impact Factor

Efficacy and Safety of Endoscopic Ultrasound-guided Choledochoduodenostomy: A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2019 Apr;53(4):243-250

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT.

Introduction: Endoscopic retrograde cholangiopancreatography is the preferred method in biliary drainage. Endoscopic ultrasound (EUS) guidance has shown tremendous success in situations where endoscopic retrograde cholangiopancreatography fails or is contraindicated. EUS-guided choledochoduodenostomy (CDD) in particular is gathering a lot of interest due to its ease, and high rates of success. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001167DOI Listing
April 2019
14 Reads

Implementation of Value-based Medicine (VBM) to Patients With Chronic Hepatitis C (HCV) Infection.

J Clin Gastroenterol 2019 Apr;53(4):262-268

Betty and Guy Beatty Center for Integrated Research, Inova Health System.

Introduction: With the significant clinical and economic burden of chronic HCV, effective treatment must be provided efficiently and appropriately. VBM is predicated upon improving health outcomes (clinical and quality) while optimizing the cost of delivering these outcomes. This review explores the concepts of VBM and how it can be used as a strategy for HCV eradication, using the United States as a case example. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001174DOI Listing
April 2019
1 Read

Among Medicare Patients With Hepatocellular Carcinoma, Non-alcoholic Fatty Liver Disease is the Most Common Etiology and Cause of Mortality.

J Clin Gastroenterol 2019 Jan 21. Epub 2019 Jan 21.

Department of Medicine and Center For Liver Disease, Inova Fairfax Hospital.

Goals: The main purpose of this study was to assess the recent trends in mortality and health care utilization of hepatocellular carcinoma (HCC) among Medicare population in the United States.

Background: The incidence of HCC is increasing in the United States.

Materials And Methods: Data were obtained for a sample of Medicare beneficiary from 2005 to 2014. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001172DOI Listing
January 2019
2 Reads

Prevalence of Functional GI Diseases and Pelvic Floor Symptoms in Marfan Syndrome and Ehlers-Danlos Syndrome: A National Cohort Study.

J Clin Gastroenterol 2019 Jan 21. Epub 2019 Jan 21.

Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston.

Background And Aims: Prior studies have shown a high prevalence of gastrointestinal (GI) symptoms, diagnoses of functional GI diseases (FGIDs), and pelvic floor symptoms associated with Ehlers-Danlos syndrome (EDS). It is unclear if Marfan syndrome (MFS), another common hereditary noninflammatory connective tissue disorder, is also associated these symptoms. This study evaluates the prevalence of and compares FGIDs and pelvic floor symptoms in a national cohort of EDS and MFS patients. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001173DOI Listing
January 2019
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Practical Perspectives in the Treatment of Nausea and Vomiting.

J Clin Gastroenterol 2019 Mar;53(3):170-178

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, MA.

Nausea and vomiting result from complex interactions between afferent and efferent pathways of the gastrointestinal tract, central nervous system, and autonomic nervous system. Afferent pathways from the vagus nerve, vestibular system, and chemoreceptor trigger zone project to nucleus tractus solitarius, which in turn relays signals to the central pattern generator to initiate multiple downstream pathways resulting in symptoms of nausea and vomiting. There is increasing evidence that the central pathway of chronic nausea is different from that of acute nausea and vomiting-and closely resembles that of neuropathic pain. Read More

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http://Insights.ovid.com/crossref?an=00004836-900000000-9778
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http://dx.doi.org/10.1097/MCG.0000000000001164DOI Listing
March 2019
38 Reads