7,995 results match your criteria Journal of clinical gastroenterology[Journal]


More Severe Deficits in Performance Status at Time of Liver Transplant is Associated With Significantly Higher Risk of Death Following Liver Transplantation.

J Clin Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology and Hepatology, Alameda Health System, Highland Hospital, Oakland, CA.

Goal: To evaluate the impact of Karnofsky Performance Status score (KPSS) at the time of liver transplantation (LT) on post-LT survival.

Background: While the Model for End-Stage Liver Disease (MELD) score is used to prioritize individuals for LT, it does not specifically incorporate functional status into patient assessment for LT.

Methods: Using 2005 to 2016 United Network for Organ Sharing data, all adults (age 18 y and above) undergoing LT were identified. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001187DOI Listing
February 2019
3.498 Impact Factor

Reflux Symptoms in Gastroparesis: Correlation With Gastroparesis Symptoms, Gastric Emptying, and Esophageal Function Testing.

J Clin Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA.

Goal: The goal of this study was to determine the relationship of reflux with gastroparesis (Gp), looking both at symptoms and objective testing.

Background: Gp patients often experience gastroesophageal reflux symptoms. How the severity of reflux correlates with the severity of Gp is not known. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001190DOI Listing
February 2019

World Gastroenterology Organisation (WGO) News and Events.

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J Clin Gastroenterol 2019 Mar;53(3):1-2

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http://dx.doi.org/10.1097/MCG.0000000000001176DOI Listing

Thirty Years of Lactobacillus rhamnosus GG: A Review.

Authors:
Lucio Capurso

J Clin Gastroenterol 2019 Mar;53 Suppl 1:S1-S41

Department of Gastroenterology, San Filippo Neri Hospital, Rome, Italy.

Lactobacillus rhamnosus GG (LGG) was the first strain belonging to the genus Lactobacillus to be patented in 1989 thanks to its ability to survive and to proliferate at gastric acid pH and in medium containing bile, and to adhere to enterocytes. Furthermore LGG is able to produces both a biofilm that can mechanically protect the mucosa, and different soluble factors beneficial to the gut by enhancing intestinal crypt survival, diminishing apoptosis of the intestinal epithelium, and preserving cytoskeletal integrity. Moreover LGG thanks to its lectin-like protein 1 and 2 inhibits some pathogens such as Salmonella species. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001170DOI Listing
March 2019
1 Read

Conditioned Pain Modulation (CPM) is Reduced in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of CPM and the Role of Psychological Factors.

J Clin Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Pain Management Research Institute, Faculty of Medicine and Health.

This systematic review summarises evidence assessing endogenous pain inhibition in people with irritable bowel syndrome (IBS) compared with healthy controls using conditioned pain modulation (CPM) and offset analgesia (OA). Evidence regarding the role of psychological variables is also examined. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001181DOI Listing
February 2019
1 Read

Transcutaneous Neuromodulation at ST36 (Zusanli) is More Effective than Transcutaneous Tibial Nerve Stimulation in Treating Constipation.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Ningbo Pace Translational Medical Research Center, Beilun.

Background And Goals: Combined transcutaneous neuromodulation (TN) at acupoint ST36 (Zusanli) and TN at the posterior tibial nerve (PTN) has been reported effective in treating functional constipation. This study was designed to compare the effectiveness of TN between these 2 points.

Materials And Methods: Eighteen functional constipation patients (M/F: 9/9) were recruited to participate in a cross-over study with a 2-week TN at ST36 and a 2-week TN at PTN. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001184DOI Listing
February 2019
1 Read

Noninvasive Assessment of Portal Hypertension Using Spectral Computed Tomography.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Department of Oncology Interventional Therapy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, China.

Background: Early diagnosis of portal hypertension is imperative for timely treatment to reduce the mortality rate. However, there is still no adequate method to noninvasively and accurately assess the portal hypertension in routine clinical practice.

Purpose: We aimed to evaluate the accuracy of parameters measured using dual energy spectral computed tomography (LightSpeed CT750 HD) in assessing portal venous pressure in patients with liver cirrhosis. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001185DOI Listing
February 2019
2 Reads

Effect of Chronic Domperidone Use on QT Interval: A Large Single Center Study.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Section of Gastroenterology, Department of Medicine, University of Florida Jacksonville, Jacksonville, FL.

Goals: The goal of this study was to determine the effect and safety of domperidone on QTc interval at the commonly prescribed doses of 30 to 80 mg daily.

Background: Domperidone is a dopamine receptor antagonist used for the treatment of gastroparesis. However, it has been associated with QT prolongation, ventricular arrhythmias, and sudden cardiac death. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001183DOI Listing
February 2019
1 Read

An Intraprocedural Endoscopic Cleansing Device for Achieving Adequate Colon Preparation in Poorly Prepped Patients.

J Clin Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Carmel Medical Center, Haifa, Israel.

Background And Aims: An effective bowel preparation is essential for quality colonoscopy. Inadequate preparation results in missed lesions, need for earlier repeat procedures, prolonged colonoscopy duration, an increased likelihood of adverse events, reduced patient satisfaction, and increased costs. The MOTUS GI Pure-Vu System (Tirat Carmel, Israel) is an Food and Drug Administration-cleared device designed to improve visualization in an inadequately prepared colon by facilitating intraprocedural cleaning. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001114DOI Listing
February 2019

GI Motility Testing: Stomach, Small Bowel, and Colon.

J Clin Gastroenterol 2019 Mar;53(3):159-169

Division of Gastroenterology, University of Michigan, Ann Arbor, MI.

Symptoms of abdominal pain, nausea, vomiting, bloating, abdominal distention, diarrhea, and constipation are common and may relate to abnormalities in gastrointestinal motility. There are a number of different options to study gastrointestinal motility. This article reviews novel and standard motility tests available in the stomach, small bowel, and colon. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001138DOI Listing
March 2019
1 Read

A Comprehensive Review of Patient-reported Outcomes in Patients With Chronic Liver Diseases.

J Clin Gastroenterol 2019 Jan 29. Epub 2019 Jan 29.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA.

Chronic liver disease (CLD) is a global health problem with chronic viral hepatitis, alcohol-related liver disease, and nonalcoholic fatty liver disease being important causes of mortality. Besides its clinical burden, patients with CLD also suffer from impairment of their health-related quality of life and other patient-reported outcomes (PRO). In this context, a combination of both clinical and PROs will allow assessment of the comprehensive burden of liver disease on patients. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001179DOI Listing
January 2019
1 Read

POEM in Latin America: The Rise of a New Standard.

J Clin Gastroenterol 2019 Jan 29. Epub 2019 Jan 29.

Gastrointestinal Endoscopy Unit, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Background: Per-oral endoscopic myotomy (POEM) has become the preferred alternative treatment to standard Heller myotomy for patients with esophageal achalasia, in Latin American countries. The aim of our study was to evaluate the efficacy and safety of a POEM in the management of achalasia with and without Chagas disease in patients receiving POEM.

Methods: Patients who underwent POEM from tertiary centers in Latin America were included in a dedicated registry. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001161DOI Listing
January 2019
3 Reads
3.498 Impact Factor

Efficacy and Safety of Endoscopic Ultrasound-guided Choledochoduodenostomy: A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT.

Introduction: Endoscopic retrograde cholangiopancreatography is the preferred method in biliary drainage. Endoscopic ultrasound (EUS) guidance has shown tremendous success in situations where endoscopic retrograde cholangiopancreatography fails or is contraindicated. EUS-guided choledochoduodenostomy (CDD) in particular is gathering a lot of interest due to its ease, and high rates of success. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001167DOI Listing
January 2019
5 Reads

Implementation of Value-based Medicine (VBM) to Patients With Chronic Hepatitis C (HCV) Infection.

J Clin Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Betty and Guy Beatty Center for Integrated Research, Inova Health System.

Introduction: With the significant clinical and economic burden of chronic HCV, effective treatment must be provided efficiently and appropriately. VBM is predicated upon improving health outcomes (clinical and quality) while optimizing the cost of delivering these outcomes. This review explores the concepts of VBM and how it can be used as a strategy for HCV eradication, using the United States as a case example. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001174DOI Listing
January 2019

Among Medicare Patients With Hepatocellular Carcinoma, Non-alcoholic Fatty Liver Disease is the Most Common Etiology and Cause of Mortality.

J Clin Gastroenterol 2019 Jan 21. Epub 2019 Jan 21.

Department of Medicine and Center For Liver Disease, Inova Fairfax Hospital.

Goals: The main purpose of this study was to assess the recent trends in mortality and health care utilization of hepatocellular carcinoma (HCC) among Medicare population in the United States.

Background: The incidence of HCC is increasing in the United States.

Materials And Methods: Data were obtained for a sample of Medicare beneficiary from 2005 to 2014. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001172DOI Listing
January 2019
1 Read

Prevalence of Functional GI Diseases and Pelvic Floor Symptoms in Marfan Syndrome and Ehlers-Danlos Syndrome: A National Cohort Study.

J Clin Gastroenterol 2019 Jan 21. Epub 2019 Jan 21.

Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston.

Background And Aims: Prior studies have shown a high prevalence of gastrointestinal (GI) symptoms, diagnoses of functional GI diseases (FGIDs), and pelvic floor symptoms associated with Ehlers-Danlos syndrome (EDS). It is unclear if Marfan syndrome (MFS), another common hereditary noninflammatory connective tissue disorder, is also associated these symptoms. This study evaluates the prevalence of and compares FGIDs and pelvic floor symptoms in a national cohort of EDS and MFS patients. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001173DOI Listing
January 2019

Practical Perspectives in the Treatment of Nausea and Vomiting.

J Clin Gastroenterol 2019 Mar;53(3):170-178

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, MA.

Nausea and vomiting result from complex interactions between afferent and efferent pathways of the gastrointestinal tract, central nervous system, and autonomic nervous system. Afferent pathways from the vagus nerve, vestibular system, and chemoreceptor trigger zone project to nucleus tractus solitarius, which in turn relays signals to the central pattern generator to initiate multiple downstream pathways resulting in symptoms of nausea and vomiting. There is increasing evidence that the central pathway of chronic nausea is different from that of acute nausea and vomiting-and closely resembles that of neuropathic pain. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001164DOI Listing
March 2019
15 Reads

Sustained Improvement in Type 2 Diabetes Mellitus is Common After Treatment of Hepatitis C Virus With Direct-acting Antiviral Therapy.

J Clin Gastroenterol 2019 Jan 4. Epub 2019 Jan 4.

Evans Department of Medicine, Section of Gastroenterology.

Goals: To determine whether diabetic patients with hepatitis C virus (HCV) treated with direct-acting antiviral agents have improved diabetes, accounting for change in both hemoglobin A1c (HbA1c) and diabetes medications, and whether any improvement was sustained.

Background: HCV infection is associated with an increased risk of diabetes, with improvement in glycemic control after eradication. There remains uncertainty about the durability and magnitude of this effect. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001168DOI Listing
January 2019
3 Reads

Chronic Liver Disease Patients have Worse Outcomes and Increased Postoperative Complications After Orthopedic Fractures.

J Clin Gastroenterol 2019 Jan 4. Epub 2019 Jan 4.

Department of Gastroenterology and Hepatology, St. Francis Hospital and Medical Center, Hartford, CT.

Introduction: Cirrhotic patients are at a higher risk for sustaining orthopedic fractures with a reported prevalence of 5% to 20%. Cirrhosis also affects wound healing and bleeding risk, and hence, impacts the postoperative outcomes after fracture repair. However, there is limited data available on the postoperative risk factors and clinical outcomes of fractures in patients with chronic liver disease (CLD). Read More

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http://dx.doi.org/10.1097/MCG.0000000000001166DOI Listing
January 2019
3 Reads

Trends in Incidence and Outcomes of Clostridium difficile Colitis in Hospitalized Patients of Febrile Neutropenia: A Nationwide Analysis.

J Clin Gastroenterol 2019 Jan 29. Epub 2019 Jan 29.

Gastroenterology & Hepatology, University of Toledo Medical Center, Toledo, OH.

Introduction: Clostridium difficile infection (CDI) has been attracting attention lately as the most common hospital acquired infection. Patients with neutropenia because of malignancy seem to be at an increased risk for developing CDI. There is currently limited data that assesses the national burden and outcomes of CDI in Febrile Neutropenia (FN). Read More

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http://dx.doi.org/10.1097/MCG.0000000000001171DOI Listing
January 2019
5 Reads

Unnecessary to Extend Postpartum Antiviral Therapy in Pregnant Women With High Hepatitis B Viral Loads.

Authors:
Yi-Hua Zhou

J Clin Gastroenterol 2019 Jan 4. Epub 2019 Jan 4.

Departments of Laboratory Medicine and Infectious Diseases, Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China.

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http://dx.doi.org/10.1097/MCG.0000000000001169DOI Listing
January 2019

IgG4 is Elevated in Eosinophilic Esophagitis but Not in Gastroesophageal Reflux Disease Patients.

J Clin Gastroenterol 2019 Jan 4. Epub 2019 Jan 4.

2nd Clinical Department for Internal Medicine.

Background: For eosinophilic esophagitis (EoE) recently an association with immunoglobulin (Ig)G4 rather than IgE has been reported. Gastroesophageal reflux disease (GERD) is the most important differential diagnosis of EoE. We compared esophageal IgG4 plasma cell infiltration and serum IgG4 levels of EoE patients (before and after budesonide therapy) with GERD patients. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001154DOI Listing
January 2019
1 Read

Clinical Outcomes Based on the Timing of Appearance of Visible Lesions in Barrett's Esophagus During Endoscopic Eradication Therapy.

J Clin Gastroenterol 2019 Jan 4. Epub 2019 Jan 4.

Biostatistics, Cleveland Clinic, Cleveland, OH.

Background And Goals: Visible lesions (VLs) in Barrett's esophagus (BE) are seen in 70% to 90% of patients presenting for endoscopic eradication therapy (EET). It is not known if there are any differences in outcomes of patients with flat dysplasia versus patients with VL. Our aim was to assess outcomes of EET in BE patients with VL and BE patients with flat dysplasia. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001165DOI Listing
January 2019
5 Reads

Haptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis.

J Clin Gastroenterol 2018 Dec 21. Epub 2018 Dec 21.

Division of Gastroenterology, Department of Internal Medicine.

Background: Haptoglobin (Hp) genotype has been linked to oxidative stress and cardiovascular outcomes in response to vitamin E (VitE) among patients with diabetes mellitus. Its effect on histologic response to VitE in nonalcoholic steatohepatitis (NASH) is unknown.

Goals: Our objective was to determine if Hp genotype associates with response to VitE in patients with NASH. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001142DOI Listing
December 2018
6 Reads

Acute Liver Failure: From Textbook to Emergency Room and Intensive Care Unit With Concomitant Established and Modern Novel Therapies.

J Clin Gastroenterol 2019 Feb;53(2):89-101

Department of Internal Medicine, Ippokration Hospital, Second Medical Clinic, Aristotle University of Thessaloniki.

Acute liver failure is a rare hepatic emergent situation that affects primarily young people and has often a catastrophic or even fatal outcome. Definition of acute liver failure has not reached a universal consensus and the interval between the appearance of jaundice and hepatic encephalopathy for the establishment of the acute failure is a matter of debate. Among the wide variety of causes, acetaminophen intoxication in western societies and viral hepatitis in the developing countries rank at the top of the etiology list. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001162DOI Listing
February 2019
5 Reads

Management of Functional Esophagogastric Junction Outflow Obstruction: A Systematic Review.

J Clin Gastroenterol 2018 Dec 19. Epub 2018 Dec 19.

Division of Gastroenterology, Duke University Medical Center.

Goals: Awareness of functional esophagogastric junction outflow obstruction (fEGJOO) has increased, but because there is no consensus on its management, we performed a systematic review of the literature to explore treatment strategies and outcomes.

Background: EGJOO is a heterogenous disorder defined by high-resolution manometry parameters of elevated integrated relaxation pressure with preserved esophageal peristalsis. The etiology may be mechanical obstruction or idiopathic, the latter being fEGJOO. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001156DOI Listing
December 2018
3 Reads

Risk Factors Associated With Upper Aerodigestive Tract or Coliform Bacterial Overgrowth of the Small Intestine in Symptomatic Patients.

J Clin Gastroenterol 2018 Dec 19. Epub 2018 Dec 19.

Divisions of Gastroenterology and Hepatology.

Introduction: The clinical relevance of bacterial types identified in small bowel aspirate cultures during diagnostic evaluation of small intestinal bacterial overgrowth (SIBO) is unclear.

Aim: The main purpose of this study was to assess associations between risk factors for upper aerodigestive tract (UAT) or coliform SIBO and SIBO diagnosis by culture.

Materials And Methods: Small bowel aspirates were cultured in patients with suspected SIBO, defined as ≥10 colony-forming units/mL coliform or ≥10 colony-forming units/mL UAT bacteria. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001150DOI Listing
December 2018
2 Reads

Risk and Protective Factors Related to Early Adverse Life Events in Irritable Bowel Syndrome.

J Clin Gastroenterol 2018 Dec 19. Epub 2018 Dec 19.

Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles.

Background: Irritable bowel syndrome (IBS) is a stress-sensitive disorder of brain-gut interactions associated with a higher prevalence of early adverse life events (EALs). However, it is incompletely understood how trauma severity or disclosure influence the risk of developing IBS or symptom severity.

Aims: To determine whether (1) IBS patients report a greater number of EALs compared with healthy controls; (2) trauma severity and first age of EAL increase the odds of IBS; (3) confiding in others reduces the odds of IBS; (4) the number, trauma severity, and first age of EAL are associated with symptom severity; (5) sex differences exist. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001153DOI Listing
December 2018
6 Reads

Baseline Impedance Measured During High-resolution Esophageal Impedance Manometry in Patients With Rumination Syndrome is as Abnormal as in Patients With GERD.

J Clin Gastroenterol 2018 Dec 19. Epub 2018 Dec 19.

Department of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale AZ.

Goals And Background: Baseline impedance measured during high-resolution impedance manometry (HRIM) can distinguish patients with gastroesophageal reflux disease (GERD) from controls, presumably due to differences in esophageal acid exposure. The characteristics of regurgitation and reflux in rumination syndrome and GERD are very different, and thus we investigated whether baseline esophageal impedance would differ in these 2 patient groups compared with controls.

Study: We compared 20 patients with rumination syndrome with 20 patients who had GERD and 40 controls. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001159DOI Listing
December 2018
3.498 Impact Factor

Second-line Treatments of Advanced Hepatocellular Carcinoma: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

J Clin Gastroenterol 2018 Dec 19. Epub 2018 Dec 19.

Hotel Dieu de France University Hospital, Faculty of Medicine, University of Saint Joseph, Beirut, Lebanon.

Background: Advanced hepatocellular carcinoma (HCC) constitutes the second leading cause of cancer-related deaths. First-line therapy is either sorafenib or lenvatinib. Several treatment options have been recently added to the second-line treatment of advanced HCC. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001160DOI Listing
December 2018
3.498 Impact Factor

Quantitative Hepatitis B Surface Antigen Predicts Hepatitis B Transmission in Infants Born to e Antigen-positive Mothers.

J Clin Gastroenterol 2018 Dec 19. Epub 2018 Dec 19.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology.

Goals: This study aimed to explore whether quantitative surface antigen [hepatitis B surface antigen (HBsAg)] can be used as a surrogate marker of hepatitis B virus (HBV) DNA to predict hepatitis B transmission before the first hepatitis vaccine dose in infants born to hepatitis B e antigen (HBeAg)-positive pregnant women.

Background: Currently, HBV transmission persistently occurs worldwide, especially in infants born to e antigen (HBeAg)-positive highly viremic mothers. However, due to high cost, the extensive use of viral load testing to identify these high-risk mothers is limited. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001158DOI Listing
December 2018

World Gastroenterology Organisation (WGO) News and Events.

Authors:

J Clin Gastroenterol 2019 Jan;53(1):1-2

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http://dx.doi.org/10.1097/MCG.0000000000001152DOI Listing
January 2019

Gastroesophageal Reflux Treatment With Proton Pump Inhibitors in Patients With Hypertension.

J Clin Gastroenterol 2019 Feb;53(2):157-158

Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

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http://dx.doi.org/10.1097/MCG.0000000000001157DOI Listing
February 2019

Pancreatic Hormone Responses to Mixed Meal Test in New-onset Prediabetes/Diabetes After Non-necrotizing Acute Pancreatitis.

J Clin Gastroenterol 2018 Nov 21. Epub 2018 Nov 21.

School of Medicine, University of Auckland, Auckland, New Zealand.

Aim: To investigate the pancreatic hormone responses to mixed meal test, in particular changes in insulin secretion, insulin sensitivity, and their interrelationship, in individuals with new-onset prediabetes or diabetes after non-necrotizing acute pancreatitis (NODAP) compared with healthy controls.

Methods: Twenty-nine individuals with NODAP and 29 age-and sex-matched healthy controls were recruited. All participants (after fasting for at least 8 h) were given 12 oz. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001145DOI Listing
November 2018
10 Reads

Insufficient Evidence to Diagnose Intrauterine Transmission of Hepatitis B Virus.

Authors:
Yi-Hua Zhou

J Clin Gastroenterol 2019 Feb;53(2):157

Departments of Laboratory Medicine and Infectious Diseases, Nanjing Drum Tower Hospital.

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http://dx.doi.org/10.1097/MCG.0000000000001155DOI Listing
February 2019
8 Reads

The Model to Estimate Survival in Ambulatory Hepatocellular Carcinoma Patients Aids in the Decision for TACE Retreatment.

J Clin Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine.

Background/aims: Transarterial chemoembolization (TACE) is a major therapeutic modality for patients with unresectable hepatocellular carcinoma, which needs repeated treatments. Model to Estimate Survival in Ambulatory Hepatocellular carcinoma patients (MESIAH) was recently developed as a model for predicting survival. We aimed to develop a novel index for TACE retreatment using MESIAH scores. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001148DOI Listing
November 2018
7 Reads
3.498 Impact Factor

A Theory-based Educational Pamphlet With Low-residue Diet Improves Colonoscopy Attendance and Bowel Preparation Quality.

J Clin Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Department of Medicine, Division of Gastroenterology and Hepatology, NYU Langone Health.

Goals/background: Patients who "no-show" for colonoscopy or present with poor bowel preparation waste endoscopic resources and do not receive adequate examinations for colorectal cancer (CRC) screening. Using the Health Belief Model, we modified an existing patient education pamphlet and evaluated its effect on nonattendance rates and bowel preparation quality.

Study: We implemented a color patient education pamphlet to target individual perceptions about CRC and changed bowel preparation instructions to include a low-residue diet instead of the previous clear liquid diet. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001151DOI Listing
November 2018

Clinical Predictors for Poor Quality of Life in Patients With Covert Hepatic Encephalopathy.

J Clin Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Department of Internal Medicine I.

Background: Current EASL/AASLD guidelines recommend treatment of covert hepatic encephalopathy (HE) only in symptomatic patients, for example, in those with impaired quality of life or with affected driving abilities.

Goals: Because testing for impaired quality of life is time consuming, the aim of the present study was to identify simple clinical predictors for poor quality of life in patients with covert HE (CHE).

Study: In total, 139 cirrhotic in- and outpatients without a history of overt hepatic encephalopathy were enrolled. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001149DOI Listing
November 2018
9 Reads

Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial.

J Clin Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Infectious Diseases Section, Internal Medicine.

Goal: To evaluate the effect of yogurt supplemented with probiotic bacteria on the prevention of antibiotic-associated diarrhea (AAD) in hospitalized patients.

Background: Diarrhea following antibiotic administration is a frequent clinical problem. The usefulness of probiotics for the prevention of AAD in the hospitalized adult population remains unclear. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001131DOI Listing
November 2018
2 Reads

Variations in Insurances Policies Regarding Adherence to the AGA Guideline for Therapeutic Drug Monitoring in IBD.

J Clin Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.

Background: The American Gastroenterological Association (AGA) published guidelines on therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD) in August 2017 recommending use of reactive TDM to guide treatment changes in patients with active IBD who are being treated with anti-tumor necrosis factor (anti-TNF) agents or thiopurines. We sought to determine if changes in national clinical practice guidelines result in changes in health care insurance policies within 6 months of publication.

Methods: Using the National Association of Insurance Commissioners Market Share Reports of the top 125 insurance companies by market share in 2016, we reviewed the largest 50 companies for their publicly available online policies regarding TDM of anti-TNF and thiopurine in IBD. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001144DOI Listing
November 2018
9 Reads

Evaluation of Baseline Impedance During Water-perfused High Resolution Impedance Manometry in Patients With Symptomatic GERD.

J Clin Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University.

Goals: We aimed to investigate the hypothesis whether baseline impedance measured during water-perfused high resolution impedance manometry (HRIM) can help discriminate patients with reflux symptoms from the controls and predict the response to the proton pump inhibitors (PPIs).

Background/aim: Baseline impedance measured during solid-state HRIM can reliably discriminate patients with gastroesophageal reflux disease (GERD) from controls.

Study: We enrolled consecutive patients with typical reflux symptoms and healthy controls for the measurement of baseline impedance during the landmark period of HRIM. Read More

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http://Insights.ovid.com/crossref?an=00004836-900000000-9779
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http://dx.doi.org/10.1097/MCG.0000000000001147DOI Listing
November 2018
9 Reads
3.500 Impact Factor

Impact of Cytomegalovirus Infection on the Outcome of Patients With Cirrhosis: A Preliminary Study.

J Clin Gastroenterol 2019 Mar;53(3):236-241

Hepatology Department.

Goals: The aims of this study were to evaluate whether cytomegalovirus (CMV) infection is associated with hepatocellular carcinoma (HCC) and liver-related mortality in cirrhotic patients.

Background: In cirrhotic patients, the determinants of HCC and liver-related death are imperfectly known. CMV infection, by its prooncogenic and proinflammatory properties, may favor both the development of HCC and deleterious systemic inflammation. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001039DOI Listing
March 2019
2 Reads

Time for a Changing of Guard: From Minimally Invasive Surgery to Endoscopic Drainage for Management of Pancreatic Walled-off Necrosis.

J Clin Gastroenterol 2019 Feb;53(2):81-88

Division of Gastroenterology, University of North Carolina, Chapel Hill, NC.

Background And Aims: Endoscopic drainage (ED) with or without necrosectomy, and minimally invasive surgical necrosectomy (MISN) have been increasingly utilized for treatment of symptomatic sterile and infected pancreatic walled-off necrosis (WON). We conducted this systematic review to compare the safety of ED with MISN for management of WON.

Methods: We searched several databases from inception through November 9, 2017 to identify comparative studies evaluating the safety of ED versus MISN for management of WON. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001141DOI Listing
February 2019
3 Reads
3.500 Impact Factor

Risk of Renal Injury After the Use of Polyethylene Glycol for Outpatient Colonoscopy: A Prospective Observational Study.

J Clin Gastroenterol 2018 Oct 24. Epub 2018 Oct 24.

Department of Medicine, Evergreen General Hospital.

Goal: The goal of this study was to estimate the risk of renal injury after the use of 3-L polyethylene glycol (PEG) before outpatient colonoscopy.

Background: Population-based studies showed that the use of PEG was associated with renal injury, but this association has not been confirmed by prospective study.

Study: Patients ≥40 years of age with an estimated glomerular filtration rate ≥30 mL/min were screened for enrollment. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001140DOI Listing
October 2018
5 Reads

Financial Toxicity in Crohn's Disease.

J Clin Gastroenterol 2018 Oct 24. Epub 2018 Oct 24.

Departments of Surgery.

Background: A patient-reported outcome measure called Comprehensive Score for Financial Toxicity (COST) was previously developed and validated in patients with cancer.

Goals: We sought to assess the financial toxicity associated with Crohn's disease (CD) by administering the COST questionnaire to patients treated at a tertiary care center.

Study: Forty-eight patients diagnosed with CD completed questionnaires, which included the COST quality of life instrument as well as questions with regard to sociodemographics and clinical characteristics. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001139DOI Listing
October 2018
3 Reads

Implementation of a Defecation Posture Modification Device: Impact on Bowel Movement Patterns in Healthy Subjects.

J Clin Gastroenterol 2019 Mar;53(3):216-219

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Medical Center.

Goals: The goal of this study was to evaluate the influence of defecation postural modification devices (DPMDs) on normal bowel patterns.

Background: The introduction of DPMDs has brought increased awareness to bowel habits in western populations.

Materials And Methods: A prospective crossover study of volunteers was performed that included real-time collection of data regarding bowel movements (BMs) for 4 weeks (first 2 wk without DPMD and subsequent 2 wk with DPMD). Read More

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http://dx.doi.org/10.1097/MCG.0000000000001143DOI Listing

Comparison Between an Oral Sulfate Solution and a 2 L of Polyethylene Glycol+Ascorbic Acid as a Split Dose Bowel Preparation for Colonoscopy.

J Clin Gastroenterol 2018 Oct 10. Epub 2018 Oct 10.

Department of Internal Medicine, Division of Gastroenterology, College of Medicine, The Catholic University of Korea.

Background/aims: This study aimed to compare the efficacy and tolerability of an oral sulfate solution (OSS) versus 2 L of polyethylene glycol/ascorbic acid (2L-PEG/Asc) for bowel cleansing before colonoscopy.

Methods: A prospective, single-center, single-blinded, noninferiority, randomized, controlled trial was performed. The primary outcome was the rate of successful bowel cleansing, evaluated using the Boston Bowel Preparation Scale (BBPS). Read More

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http://Insights.ovid.com/crossref?an=00004836-900000000-9780
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http://dx.doi.org/10.1097/MCG.0000000000001137DOI Listing
October 2018
2 Reads

World Gastroenterology Organisation (WGO) News and Events.

Authors:

J Clin Gastroenterol 2018 Nov/Dec;52(10):1-2

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http://dx.doi.org/10.1097/MCG.0000000000001134DOI Listing
October 2018