27,565,350 results match your criteria Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism[Journal]

  • Page 1 of 551307

Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus.

Viruses 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Lymphocytic choriomeningitis virus (LCMV) is a paradigm-forming experimental system with a remarkable track record of contributing to the discovery of many of the fundamental concepts of modern immunology. The ability of LCMV to establish a chronic infection in immunocompetent adult mice was instrumental for identifying T cell exhaustion and this system has been invaluable for uncovering the complexity, regulators, and consequences of this state. These findings have been directly relevant for understanding why ineffective T cell responses commonly arise during many chronic infections including HIV and HCV, as well as during tumor outgrowth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11020156DOI Listing
February 2019

N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling.

Genes (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.

Despite recent advances in ⁶-methyladenosine (m⁶A) biology, the regulation of crucial RNA processing steps by the RNA methyltransferase-like 3 (METTL3) in glioma stem-like cells (GSCs) remains obscure. An integrated analysis of m⁶A-RIP (RNA immunoprecipitation) and total RNA-Seq of METTL3-silenced GSCs identified that m⁶A modification in GSCs is principally carried out by METTL3. The m⁶A-modified transcripts showed higher abundance compared to non-modified transcripts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10020141DOI Listing
February 2019

Vitamin B Status in Pregnant Adolescents and Their Infants.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

Vitamin B deficiency has been associated with increased risk of adverse pregnancy outcomes. Few prospective studies have investigated the burden or determinants of vitamin B deficiency early in life, particularly among pregnant adolescents and their children. The objectives of this study were to determine the prevalence of vitamin B deficiency and to examine associations between maternal and neonatal vitamin B status in a cohort study of healthy pregnant adolescents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11020397DOI Listing
February 2019

Palm Oil in Lipid-Based Formulations and Drug Delivery Systems.

Biomolecules 2019 Feb 13;9(2). Epub 2019 Feb 13.

Department of Biochemistry, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, 47000 Sungai Buloh, Selangor, Malaysia.

Palm oil is natural oil packed with important compounds and fatty acids ready to be exploited in lipid-based formulations and drug delivery. Palm oil and palm kernel oil contain long-chain and medium-chain triglycerides, respectively, including phytonutrients such as tocotrienol, tocopherol and carotenes. The exploitation of these compounds in a lipid-based formulation would be able to address hydrophobicity, lipophilicity, poor bioavailability and low water-solubility of many current drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9020064DOI Listing
February 2019

Nanosecond-Laser Generation of Nanoparticles in Liquids: From Ablation through Bubble Dynamics to Nanoparticle Yield.

Materials (Basel) 2019 Feb 13;12(4). Epub 2019 Feb 13.

ITMO University, 197101 St. Petersburg, Russia.

A comprehensive picture of the nanosecond-laser generation of colloidal nanoparticles in liquids is nowadays the demand of their high-throughput industrial fabrication for diverse perspective biomedical, material science, and optoelectronic applications. In this study, using silicon as an example, we present a self-consistent experimental visualization and theoretical description of key transient stages during nanosecond-laser generation of colloidal nanoparticles in liquids: plasma-mediated injection of ablated mass into the liquid and driving the vapor bubble, finalized by the colloid appearance in the liquid. The explored fundamental transient stages envision the basic temporal and spatial scales, as well as laser parameter windows, for the demanded high-throughput nanosecond-laser generation of colloidal nanoparticles in liquids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma12040562DOI Listing
February 2019

Ventilator-Associated Pneumonia due to Drug-Resistant : Risk Factors and Mortality Relation with Resistance Profiles, and Independent Predictors of In-Hospital Mortality.

Medicina (Kaunas) 2019 Feb 13;55(2). Epub 2019 Feb 13.

Department of Intensive Care, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.

High mortality and healthcare costs area associated with ventilator-associated pneumonia (VAP) due to (). The data concerning the link between multidrug-resistance of strains and outcomes remains controversial. Therefore, we aimed to identify the relation of risk factors for ventilator-associated pneumonia (VAP) and mortality with the drug resistance profiles of () and independent predictors of in-hospital mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55020049DOI Listing
February 2019

Red Quinoa Bran Extracts Protects against Carbon Tetrachloride-Induced Liver Injury and Fibrosis in Mice via Activation of Antioxidative Enzyme Systems and Blocking TGF-β1 Pathway.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Life Science, National Taitung University, Taitung 950, Taiwan.

The late stages of liver fibrosis are considered to be irreversible. Red quinoa ( Koidz), a traditional food for Taiwanese aborigines, was gradually developed as a novel supplemental food due to high dietary fibre and polyphenolic compounds. Its bran was usually regarded as the agricultural waste, but it contained a high concentration of rutin known as an antioxidant and anti-inflammatory agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11020395DOI Listing
February 2019

Development of A New Type of 2-DOF Piezo-Actuated Pseudo-Decoupled Compliant Mechanism for Elliptical Vibration Machining.

Micromachines (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

School of Mechanical and Aerospace Engineering, Jilin University, Changchun 130022, China.

Currently, the elliptical vibration cutting/coining (EVC²) has been widely employed in fabricating various functional microstructure surfaces applied in many significant engineering fields. Therefore, for this study, a novel type of two-degree-of-freedom (2-DOF) piezoelectrically actuated pseudo-decoupled compliant mechanisms (PDCMs) with non-orthogonal decoupling structures, which can exactly generate the strict ellipse trajectories, was developed for improving the forming accuracies of the EVC² microstructures. First, the compliance matrices of 2-DOF PDCMs were theoretically modeled using the popular finite beam-based matrix modeling (FBMM) and the matrix-based compliance modeling (MCM) methods, then finite element analysis (FEA) was adopted to verify the effectiveness of the built compliance model for the 2-DOF PDCM with arbitrary structure parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/mi10020122DOI Listing
February 2019

Racial and Income Disparities in Health-Related Quality of Life among Smokers with a Quit Attempt in Louisiana.

Medicina (Kaunas) 2019 Feb 13;55(2). Epub 2019 Feb 13.

Behavioral and Community Health Sciences, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

Smoking is associated with a lower health-related quality of life (HRQOL). However, there is little information about the association between HRQOL in relation to race, income, and smoking status. The present study aimed to assess the association between HRQOL and smoking status for those of different races and income levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55020048DOI Listing
February 2019

The Effect of Buffers on Weak Acid Uptake by Vesicles.

Biomolecules 2019 Feb 13;9(2). Epub 2019 Feb 13.

Institute of Biophysics, Johannes Kepler University Linz, Gruberstr. 40, 4020 Linz, Austria.

The assessment of weak acid membrane permeability () frequently involves large unilamellar vesicles. It relies on measurements of the intravesicular pH drop, ΔpH, in response to a sudden augmentation of external acid concentration. However, ΔpH may be primarily governed by non-instantaneous protonation and deprotonation reactions of (i) the acid itself, (ii) the buffer molecules, and (iii) the fluorescent pH reporter dye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9020063DOI Listing
February 2019

Developmental Toxicity of Mycotoxin B₁ in Animal Embryogenesis: An Overview.

Toxins (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan.

A teratogenic agent or teratogen can disturb the development of an embryo or a fetus. B₁ (FB₁), produced by and , is among the most commonly seen mycotoxins and contaminants from stale maize and other farm products. It may cause physical or functional defects in embryos or fetuses, if the pregnant animal is exposed to mycotoxin FB₁. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11020114DOI Listing
February 2019

Effect of Marine Basidiomycetes sp.-Derived Ergosterol Peroxide on Cytotoxicity and Apoptosis Induction in MCF-7 Cell Line.

J Fungi (Basel) 2019 Feb 13;5(1). Epub 2019 Feb 13.

Centre of Advanced Study in Marine Biology, Annamalai University, Parangipettai 608 502, India.

The aim of the present study is to extract the bioactive compounds which can induce the apoptosis in breast cancer cell line MCF-7 by marine basidiomycetes. Internal Transcribed Spacer (ITS) sequences based molecular taxonomic study confirmed that collected the marine basidiomycetes belongs to sp. Further, the isolated compounds from the sp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jof5010016DOI Listing
February 2019

Time Trends in Age at Menarche and Related Non-Communicable Disease Risk during the 20th Century in Mexico.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Division of Human Nutrition and Health, Wageningen University and Research, 6708WE Wageningen, The Netherlands.

Developed countries have shown a time trend towards a younger age at menarche (AAM), which is associated with increased risk of later obesity and non-communicable diseases. This study aimed to assess whether a time trend in AAM is associated with disease risk in Mexican women ( = 30,826), using data from the Mexican National Health Survey (2000). Linear and log binomial regression was used for nutritional and disease outcomes, while Welch⁻ANOVA was used to test for a time trend. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11020394DOI Listing
February 2019

A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions.

Genes (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.

Post-traumatic stress disorder (PTSD) is an acquired psychiatric disorder with functionally impairing physiological and psychological symptoms following a traumatic exposure. Genetic, epigenetic, and environmental factors act together to determine both an individual's susceptibility to PTSD and its clinical phenotype. In this literature review, we briefly review the candidate genes that have been implicated in the development and severity of the PTSD phenotype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10020140DOI Listing
February 2019

Tempo-Spatial Pattern of Stepharine Accumulation in Morphogenic Tissues.

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Federal Scientific Center of the East Asia Terrestrial Biodiversity (Institute of Biology and Soil Science), Far Eastern Branch of the Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, Russia.

Alkaloids attract great attention due to their valuable therapeutic properties. Stepharine, an aporphine alkaloid of plants, exhibits anti-aging, anti-hypertensive, and anti-viral effects. The distribution of aporphine alkaloids in cell cultures, as well as whole plants is unknown, which hampers the development of bioengineering strategies toward enhancing their production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20040808DOI Listing
February 2019

Evaluation of Inertial Sensor-Based Pre-Impact Fall Detection Algorithms Using Public Dataset.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

Department of Biomedical Engineering, Yonsei University, Wonju 26493, Korea.

In this study, pre-impact fall detection algorithms were developed based on data gathered by a custom-made inertial measurement unit (IMU). Four types of simulated falls were performed by 40 healthy subjects (age: 23.4 ± 4. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1424-8220/19/4/774
Publisher Site
http://dx.doi.org/10.3390/s19040774DOI Listing
February 2019
1 Read

Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania.

Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24040667DOI Listing
February 2019

Modelling the Influence of Waste Rubber on Compressive Strength of Concrete by Artificial Neural Networks.

Materials (Basel) 2019 Feb 13;12(4). Epub 2019 Feb 13.

Faculty of Civil Engineering and Architecture, University of J.J. Strossmayer, Vladimira Preloga 3, 31000 Osijek, Croatia.

One of the major causes of ecological and environmental problems comes from the enormous number of discarded waste tires, which is directly connected to the exponential growth of the world's population. In this paper, previous works carried out on the effects of partial or full replacement of aggregate in concrete with waste rubber on some properties of concrete were investigated. A database containing 457 mixtures with partial or full replacement of natural aggregate with waste rubber in concrete provided by different researchers was formed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma12040561DOI Listing
February 2019

The Oral Health of Refugees and Asylum Seekers in Canada: A Mixed Methods Study Protocol.

Int J Environ Res Public Health 2019 Feb 13;16(4). Epub 2019 Feb 13.

Faculty of Dentistry, McGill University, 500-2001 McGill College, Montréal, QC H3A 1G1, Canada.

Canada received over 140,000 refugees and asylum seekers between 2015 and 2017. This paper presents a protocol with the purpose of generating robust baseline data on the oral health of this population and build a long-term program of research to improve their access to dental care in Canada. The three-phase project uses a sequential mixed methods design, with the Behavioral Model for Vulnerable Populations as the conceptual framework. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16040542DOI Listing
February 2019

Antioxidative Peptides from Proteolytic Hydrolysates of False Abalone (): Characterization, Identification, and Molecular Docking.

Mar Drugs 2019 Feb 13;17(2). Epub 2019 Feb 13.

School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China.

Antioxidative peptides were produced from false abalone () using enzymatic hydrolysis. Trypsin produced the most bioactive hydrolysates with the highest scavenging ABTS free radicals compared to pepsin, alcalase, neutrase, and flavourzyme. The response surface methodology studies on trypsin hydrolysis indicated that the hydrolysis temperature, time, and pH were interacted with each other ( < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/md17020116DOI Listing
February 2019

Multivariate Statistical Optimization of Tablet Formulations Incorporating High Doses of a Dry Herbal Extract.

Pharmaceutics 2019 Feb 13;11(2). Epub 2019 Feb 13.

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.

The development of oral tablet formulation for herbal medicines has been restricted by large drug loadings and the poor physicochemical and mechanical properties of dry herbal extracts (DHEs). Herein, statistical experimental designs were applied to herbal tablet formulation development and optimization using Wuzi Yanzong dry extract (WYE). The tablet disintegration time and hardness were identified as the critical quality attributes (CQAs) of the product. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmaceutics11020079DOI Listing
February 2019

Fabrication of a Low Adhesive Superhydrophobic Surface on Ti6Al4V Alloys Using TiO₂/Ni Composite Electrodeposition.

Micromachines (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

School of Mechanical Engineering, Shandong University of Technology, Zibo 255000, China.

A superhydrophobic surface with low adhesion and good wear resistance was fabricated on Ti6Al4V substrates via TiO₂/Ni composite electrodeposition, and subsequently modified with a fluoroalkylsilane (FAS) film. Scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and optical contact angle measurements were used to characterize the surface morphologies, chemical compositions, and surface wettability. The superhydrophobicity of the as-prepared surface results from the fabrication of a hierarchical structure and the assembly of low-surface energy fluorinated components. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/mi10020121DOI Listing
February 2019

Preventive Effect of YGDEY from Tilapia Fish Skin Gelatin Hydrolysates against Alcohol-Induced Damage in HepG2 Cells through ROS-Mediated Signaling Pathways.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China.

According to a previous study, YGDEY from tilapia fish skin gelatin hydrolysates has strong free radical scavenging activity. In the present study, the protective effect of YGDEY against oxidative stress induced by ethanol in HepG2 cells was investigated. First, cells were incubated with YGDEY (10, 20, 50, and 100 μM) to assess cytotoxicity, and there was no significant change in cell viability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11020392DOI Listing
February 2019

New Insights into Long Non-Coding RNA in Cancer and Metastasis.

Authors:
Yutong Sun Li Ma

Cancers (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Metastasis-associated lung adenocarcinoma transcript 1 () is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly conserved among mammalian species, and based on in vitro results, has been reported to regulate alternative pre-mRNA splicing and gene expression. However, knockout mice develop and grow normally, and do not show alterations in alternative splicing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020216DOI Listing
February 2019

Relationship Between Circulating Serpina3g, Matrix Metalloproteinase-9, and Tissue Inhibitor of Metalloproteinase-1 and -2 with Chronic Obstructive Pulmonary Disease Severity.

Biomolecules 2019 Feb 13;9(2). Epub 2019 Feb 13.

Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, Turkey.

Chronic obstructive pulmonary disease (COPD) is influenced by genetic and environmental factors. A protease-antiprotease imbalance has been suggested as a possible pathogenic mechanism for COPD. Here, we examined the relationship between circulating serpina3g, matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1 and -2, respectively) and severity of COPD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9020062DOI Listing
February 2019

Improvement of Sensing Performance of Impedancemetric C₂H₂ Sensor Using SmFeO₃ Thin-Films Prepared by a Polymer Precursor Method.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

Department of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata, Kitakyushu 804-8550, Fukuoka, Japan.

A sensitive an impedancemetric acetylene (C₂H₂) gas sensor device could be fabricated by using perovskite-type SmFeO₃ thin-film as a sensor material. The uniform SmFeO₃ thin-films were prepared by spin-coating and focusing on the effects of polymer precursor solutions. The prepared precursors and thin-films were characterized by means of thermal analysis, Fourier-transform infrared spectroscopy, ultraviolet⁻visible spectroscopy, X-ray diffraction analysis, scanning electron microscopy and X-ray photoelectron spectroscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040773DOI Listing
February 2019

Microbial Asymmetric Functionalization of β-Cyclocitral-Derived Tetramethyl-Substituted γ-Lactone.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.

Searching for the new anticancer compounds we prepared three new β-cyclocitral-derived hydroxyl-γ-lactones by microbial hydroxylation of tetramethyl-substituted bicyclic γ-lactone. The substrate was transformed by the enzymatic system of filamentous fungi. Three out of fifteen strains were selected as effective biocatalysts ( AM10, AM296, AM536). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24040666DOI Listing
February 2019

Overview of Human Intervention Studies Evaluating the Impact of the Mediterranean Diet on Markers of DNA Damage.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, 20122 Milan, Italy.

The Mediterranean diet (MD) is characterized by high consumption of fruits, vegetables, cereals, potatoes, poultry, beans, nuts, lean fish, dairy products, small quantities of red meat, moderate alcohol consumption, and olive oil. Most of these foods are rich sources of bioactive compounds which may play a role in the protection of oxidative stress including DNA damage. The present review provides a summary of the evidence deriving from human intervention studies aimed at evaluating the impact of Mediterranean diet on markers of DNA damage, DNA repair, and telomere length. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11020391DOI Listing
February 2019

An Integrative Systems Perspective on Plant Phosphate Research.

Genes (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

School of Animal, Rural and Environmental Sciences, Nottingham Trent University, Nottingham NG25 0 QF, UK.

The case for improving crop phosphorus-use-efficiency is widely recognized. Although much is known about the molecular and regulatory mechanisms, improvements have been hampered by the extreme complexity of phosphorus (P) dynamics, which involves soil chemistry; plant-soil interactions; uptake, transport, utilization and remobilization within plants; and agricultural practices. The urgency and direction of phosphate research is also dependent upon the finite sources of P, availability of stocks to farmers and reducing environmental hazards. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10020139DOI Listing
February 2019

Synergistic Effects of Bortezomib-OV Therapy and Anti-Invasive Strategies in Glioblastoma: A Mathematical Model.

Cancers (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

School of Mathematics, University of Minnesota, Minneapolis, MN 55455, USA.

It is well-known that the tumor microenvironment (TME) plays an important role in the regulation of tumor growth and the efficacy of anti-tumor therapies. Recent studies have demonstrated the potential of combination therapies, using oncolytic viruses (OVs) in conjunction with proteosome inhibitors for the treatment of glioblastoma, but the role of the TME in such therapies has not been studied. In this paper, we develop a mathematical model for combination therapies based on the proteosome inhibitor bortezomib and the oncolytic herpes simplex virus (oHSV), with the goal of understanding their roles in bortezomib-induced endoplasmic reticulum (ER) stress, and how the balance between apoptosis and necroptosis is affected by the treatment protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020215DOI Listing
February 2019

Effect of Prophylactic Amiodarone Infusion on the Recurrence of Ventricular Arrhythmias in Out-of-Hospital Cardiac Arrest Survivors: A Propensity-Matched Analysis.

J Clin Med 2019 Feb 13;8(2). Epub 2019 Feb 13.

Department of Emergency Medicine, Ulsan University College of Medicine, Asan Medical Center, Seoul 05505, Korea.

Amiodarone is recommended for shock-refractory ventricular arrhythmia during resuscitation; however, it is unknown whether amiodarone is effective for preventing ventricular arrhythmia recurrence in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). We investigated the effectiveness of prophylactic amiodarone in preventing ventricular arrhythmia recurrence in OHCA survivors. Data of consecutive adult non-traumatic OHCA survivors treated with TTM between 2010 and 2016 were extracted from prospective cardiac arrest registries of four tertiary care hospitals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8020244DOI Listing
February 2019

Fully Open-Access Passive Dry Electrodes BIOADC: Open-Electroencephalography (EEG) Re-Invented.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

School of Engineering, Macquarie University, Ryde, NSW 2113, Australia.

The Open-electroencephalography (EEG) framework is a popular platform to enable EEG measurements and general purposes Brain Computer Interface experimentations. However, the current platform is limited by the number of available channels and electrode compatibility. In this paper we present a fully configurable platform with up to 32 EEG channels and compatibility with virtually any kind of passive electrodes including textile, rubber and contactless electrodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040772DOI Listing
February 2019

Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran.

Medicina (Kaunas) 2019 Feb 13;55(2). Epub 2019 Feb 13.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.

Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of as well as genes on ischemic stroke. In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for C677T, , and , , and prothrombin polymorphisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55020047DOI Listing
February 2019

Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C).

Pharmaceutics 2019 Feb 13;11(2). Epub 2019 Feb 13.

UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Salcaprozate sodium (SNAC) and sodium caprate (C) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action. C acts via openings of epithelial tight junctions and/or membrane perturbation, while for decades SNAC was thought to increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmaceutics11020078DOI Listing
February 2019
1 Read

Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors.

Toxins (Basel) 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Chemistry and Biochemistry, Boise State University; Boise, ID 83725, USA.

Nicotinic acetylcholine receptors (nAChRs) are found throughout the mammalian body and have been studied extensively because of their implication in a myriad of diseases. α-Conotoxins (α-CTxs) are peptide neurotoxins found in the venom of marine snails of genus . α-CTxs are potent and selective antagonists for a variety of nAChR isoforms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins11020113DOI Listing
February 2019

UAV Sensor Fault Detection Using a Classifier without Negative Samples: A Local Density Regulated Optimization Algorithm.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

School of Electronics and Information Engineering, Harbin Institute of Technology, Harbin 150080, China.

Fault detection for sensors of unmanned aerial vehicles is essential for ensuring flight security, in which the flight control system conducts real-time control for the vehicles relying on the sensing information from sensors, and erroneous sensor data will lead to false flight control commands, causing undesirable consequences. However, because of the scarcity of faulty instances, it still remains a challenging issue for flight sensor fault detection. The one-class support vector machine approach is a favorable classifier without negative samples, however, it is sensitive to outliers that deviate from the center and lacks a mechanism for coping with them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040771DOI Listing
February 2019

Trace Voltammetric Determination of Lead at a Recycled Battery Carbon Rod Electrode.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

Faculty of Applied Sciences, University of the West of England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK.

Carbon rod electrodes (CREs) were obtained from recycled zinc⁻carbon batteries and were used without further modification for the measurement of trace concentrations of lead (Pb). The electrochemical behavior of Pb at these electrodes in a variety of supporting electrolytes was investigated by cyclic voltammetry. The anodic peaks obtained on the reverse scans were indicative of Pb being deposited as a thin layer on the electrode surface. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040770DOI Listing
February 2019

Family Factors Associated with Selected Childhood Nutrition Aspects in Central Poland.

Int J Environ Res Public Health 2019 Feb 13;16(4). Epub 2019 Feb 13.

Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences WULS-SGGW, 159c Nowoursynowska Str., 02-776 Warsaw, Poland.

Childhood diet has a significant influence on diet-related diseases in adulthood, so an understanding of environmental influences on nutrition, is important. The aim of this cross-sectional study was to indicate family factors associated with some aspects of children's nutrition in Central Poland. A questionnaire was used to investigate 892 mothers' approach to breastfeeding, frequency of eating with children at fast food restaurants, and serving them snacks, sugary drinks, and fried food. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16040541DOI Listing
February 2019

Spatio-Temporal Transcriptional Dynamics of Maize Long Non-Coding RNAs Responsive to Drought Stress.

Genes (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

Long non-coding RNAs (lncRNAs) have emerged as important regulators in plant stress response. Here, we report a genome-wide lncRNA transcriptional analysis in response to drought stress using an expanded series of maize samples collected from three distinct tissues spanning four developmental stages. In total, 3488 high-confidence lncRNAs were identified, among which 1535 were characterized as drought responsive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10020138DOI Listing
February 2019

Study on Health Assessment Method of a Braking System of a Mine Hoist.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

School of Mechanical Electronic & Information Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China.

This paper presents a method for calculating the health degree (HD) of a braking system of a mine hoist combined with three-level fuzzy comprehensive assessment (TLFCA) and a back-propagation neural network (BPNN). Firstly, the monitored values of a sensor are fused by multi-time fusion and the fuzzy comprehensive assessment values (FCAVs) of the health condition (HC) of the sensor are obtained. Secondly, the FCAVs of all sensors in a subsystem are fused by multi-sensor fusion, and FCAVs of the subsystem are obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040769DOI Listing
February 2019

Robust Inertial Measurement Unit-Based Attitude Determination Kalman Filter for Kinematically Constrained Links.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

Inertial Motion Capture Lab, Department of Mechanical Engineering, Hankyong National University, Anseong 17579, Korea.

The external acceleration of a fast-moving body induces uncertainty in attitude determination based on inertial measurement unit (IMU) signals and thus, frequently degrades the determination accuracy. Although previous works adopt acceleration-compensating mechanisms to deal with this problem, they cannot completely eliminate the uncertainty as they are, inherently, approaches to an underdetermined problem. This paper presents a novel constraint-augmented Kalman filter (KF) that eliminates the acceleration-induced uncertainty for a robust IMU-based attitude determination when IMU is attached to a constrained link. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040768DOI Listing
February 2019

Synthesis, Physical Properties, and Reactivity of Stable, π-Conjugated, Carbon-Centered Radicals.

Authors:
Takashi Kubo

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Recently, long-lived, organic radical species have attracted much attention from chemists and material scientists because of their unique electronic properties derived from their magnetic spin and singly occupied molecular orbitals. Most stable and persistent organic radicals are heteroatom-centered radicals, whereas carbon-centered radicals are generally very reactive and therefore have had limited applications. Because the physical properties of carbon-centered radicals depend predominantly on the topology of the π-electron array, the development of new carbon-centered radicals is key to new basic molecular skeletons that promise novel and diverse applications of spin materials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24040665DOI Listing
February 2019

ID Insertion and Data Tracking with Frequency Offset for Physical Wireless Parameter Conversion Sensor Networks.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

Advanced Wireless and Communication Research Center (AWCC), The University of Electro-Communications, Tokyo 182-8585, Japan.

As the applications of the internet of things are becoming widely diversified, wireless sensor networks require real-time data reception, accommodation of access from several sensors, and low power consumption. In physical wireless parameter conversion sensor networks (PhyC-SN), all the sensors use frequency shift keying as the modulation scheme and then access the channel to the fusion center, simultaneously. As a result, the fusion center can recognize the statistical tendency of all the sensing results at a time from the frequency spectrum of the received signal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040767DOI Listing
February 2019

Virulence of Two Entomophthoralean Fungi, and , to Their Conspecific () and Heterospecific () Aphid Hosts.

Insects 2019 Feb 13;10(2). Epub 2019 Feb 13.

Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 3rd floor, 1871 Frederiksberg C, Denmark.

and (phylum Entomophthoromycota) are important fungal pathogens on cereal aphids, and . Here, we evaluated and compared for the first time the virulence of these two fungi, both produced in cadavers, against the two aphid species subjected to the same exposure. Two laboratory bioassays were carried out using a method imitating entomophthoralean transmission in the field. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/insects10020054DOI Listing
February 2019

Protein Disulfide Isomerase Inhibitor Suppresses Viral Replication and Production during Antibody-Dependent Enhancement of Dengue Virus Infection in Human Monocytic Cells.

Viruses 2019 Feb 13;11(2). Epub 2019 Feb 13.

Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

One of several mechanisms that leads to the development of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) is called antibody-dependent enhancement (ADE). Monocytes can be infected by the ADE phenomenon, which occurs in dengue secondary infection. This study aimed to investigate the proteins involved in ADE of DENV infection in the human monocytic cell line U937. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11020155DOI Listing
February 2019

Systematic Review of the Current Status of Human Sarcoma Cell Lines.

Cells 2019 Feb 13;8(2). Epub 2019 Feb 13.

Division of Rare Cancer Research, National Cancer Center Research Institute, Tokyo 1040045, Japan.

Sarcomas are rare mesenchymal malignant tumors with unique biological and clinical features. Given their diversity, heterogeneity, complexity, and rarity, the clinical management of sarcomas is quite challenging. Cell lines have been used as indispensable tools for both basic research and pre-clinical studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8020157DOI Listing
February 2019

Optimization of Reconfigurable Satellite Constellations Using Simulated Annealing and Genetic Algorithm.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Agile Earth observation can be achieved with responsiveness in satellite launches, sensor pointing, or orbit reconfiguration. This study presents a framework for designing reconfigurable satellite constellations capable of both regular Earth observation and disaster monitoring. These observation modes are termed global observation mode and regional observation mode, constituting a reconfigurable satellite constellation (ReCon). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040765DOI Listing
February 2019

Smart Aging System: Uncovering the Hidden Wellness Parameter for Well-Being Monitoring and Anomaly Detection.

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

CIME, Department of Electronic Engineering, School of Information Science and Technology, Fudan University, Shanghai 200433, China.

Background: Ambiguities and anomalies in the Activity of Daily Living (ADL) patterns indicate deviations from Wellness. The monitoring of lifestyles could facilitate remote physicians or caregivers to give insight into symptoms of the disease and provide health improvement advice to residents; Objective: This research work aims to apply lifestyle monitoring in an ambient assisted living (AAL) system by diagnosing conduct and distinguishing variation from the norm with the slightest conceivable fake alert. In pursuing this aim, the main objective is to fill the knowledge gap of two contextual observations (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19040766DOI Listing
February 2019

Nutrition Knowledge Translation Performance in Health Professionals: Findings from the 2017 Unified Forces Preventive Nutrition Conference (UFPN).

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel 40700, Israel.

Background: Dietitians and other health care professionals must be able to translate findings from clinical trials into best treatment practices, a skill termed "knowledge translation". This skill requires knowledge of treatment guidelines as well as the science underpinning treatment recommendations. Unsatisfactory knowledge translation of medical nutrition therapy (MNT) has been documented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11020390DOI Listing
February 2019
  • Page 1 of 551307