5,771 results match your criteria Journal of cancer research and clinical oncology[Journal]


First-line afatinib vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients who continued treatment beyond progression.

J Cancer Res Clin Oncol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon- dong, Gangnam-gu, Seoul, 135-710, South Korea.

Purpose: In the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer. We report post hoc analyses of tolerability-guided dose adjustment for afatinib and summarize the clinical characteristics of patients who continued afatinib/gefitinib beyond initial radiological progression in LUX-Lung 7.

Methods: Patients received afatinib 40 mg/day or gefitinib 250 mg/day until investigator-assessed progression or beyond if beneficial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02862-xDOI Listing
February 2019

CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy.

J Cancer Res Clin Oncol 2019 Feb 18. Epub 2019 Feb 18.

Antibody Engineering Laboratory, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 154#, Tong Jia Xiang 24, Nanjing, 210009, People's Republic of China.

Purpose: Bi-specific antibody (BsAb) is an emerging novel format of antibody. We aimed to develop the natural killer (NK) cell receptor NK group 2, member D (NKG2D)-mediated, immune surveillance system. In this system, the NKG2D ligand MHC class I-related chain A (MICA) was fused with BsAb, which targeted a cluster of differentiation 24 (CD24), a tumor-initiating cell marker that is over-expressed on hepatocellular carcinoma (HCC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02865-8DOI Listing
February 2019

Clinical impact of circulating LAPTM4B-35 in pancreatic ductal adenocarcinoma.

J Cancer Res Clin Oncol 2019 Feb 18. Epub 2019 Feb 18.

Department of General, Visceral and Transplantation Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1 (W1), 48149, Münster, Germany.

Purpose: LAPTM4B is upregulated in a wide range of cancers associated with poor prognosis. However, the clinical impact of LAPTM4B as diagnostic and prognostic marker in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Thus, the aim of the present study was to investigate the expression of LAPTM4B as circulating marker in PDAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02863-wDOI Listing
February 2019

CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.

J Cancer Res Clin Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.

Purpose: This study aimed at investigating the function and significance of CD110 expression in pancreatic cancer.

Methods: We performed immunohistochemical staining for CD110 expression in tumor samples from 86 patients with pancreatic cancer. We evaluated clinical outcomes and other clinicopathological factors to determine the significance of CD110 on survival and liver metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02860-zDOI Listing
February 2019
1 Read

Preoperative controlling nutritional status (CONUT) score as a novel immune-nutritional predictor of survival in non-metastatic clear cell renal cell carcinoma of ≤ 7 cm on preoperative imaging.

J Cancer Res Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology and Urological Science Institute, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Purpose: This study aimed at investigating the prognostic value of Preoperative controlling nutritional status (CONUT) score in non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging.

Methods: We retrospectively included 1046 among 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤ 7 cm (2005-2014) after excluding other pathology, conditions affecting CONUT score components, metastasis, regional lymphadenopathy, positive margin, and follow-up < 12 months. We defined high and low CONUT according to cut-off of (2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02846-xDOI Listing
February 2019
2 Reads

Prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers.

J Cancer Res Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

General-, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies.

Materials And Methods: This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we took advantage of our tissue microarray (TMA) containing more than 600 NSCLC specimens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02850-1DOI Listing
February 2019
1 Read

Does FDG PET/CT have a role in determining adjuvant chemotherapy in surgical margin-negative stage IA non-small cell lung cancer patients?

J Cancer Res Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: To evaluate the prognostic value of FDG PET/CT metabolic parameter compared to clinico-pathological risk factors in surgical margin-negative stage IA non-small cell lung cancer (NSCLC) patients.

Methods: 167 patients with consecutive FDG PET/CT scans from 2009 to 2015 performed for staging of NSCLC stage IA with plans for curative surgery were retrospectively reviewed. Maximum standardized uptake value (SUVmax) of primary tumor and mean SUV of liver were acquired from PET/CT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02858-7DOI Listing
February 2019
1 Read

Cancer risk in stroke survivors followed for up to 10 years in general practices in Germany.

J Cancer Res Clin Oncol 2019 Feb 9. Epub 2019 Feb 9.

Epidemiology, IQVIA, Unterschweinstiege 2-14, 60549, Frankfurt am Main, Germany.

Aims: The goal of this study was to analyze cancer risk in stroke survivors followed for up to 10 years in general practices in Germany.

Methods: The current study sample included patients who received an initial stroke diagnosis in one of 1262 general practices in Germany between 2006 and 2015 (index date). Patients without stroke were matched (1:1) to patients with stroke by age, gender, index year, and 16 comorbidities diagnosed in the 12 months prior to the index date using a propensity score method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02855-wDOI Listing
February 2019

Expression of Syk and MAP4 proteins in ovarian cancer.

J Cancer Res Clin Oncol 2019 Feb 8. Epub 2019 Feb 8.

Academic Clinical Oncology, Nottingham Breast Cancer Research Centre, School of Medicine, University of Nottingham, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, NG5 1PB, UK.

Purpose: We have previously reported on the prognostic importance of the calpain family of proteins in ovarian cancer, especially calpain-2. Spleen tyrosine kinase (Syk) phosphorylates a variety of cytoskeletal proteins with studies suggesting potential interactions between Syk and conventional calpains. Microtubule-associated protein 4 (MAP4) has been reported to be regulated by Syk. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-019-02856-9
Publisher Site
http://dx.doi.org/10.1007/s00432-019-02856-9DOI Listing
February 2019
2 Reads

Radiomics-based machine learning methods for isocitrate dehydrogenase genotype prediction of diffuse gliomas.

J Cancer Res Clin Oncol 2019 Mar 4;145(3):543-550. Epub 2019 Feb 4.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong'An Road, Xuhui District, Shanghai, 200032, China.

Purpose: Reliable and accurate predictive models are necessary to drive the success of radiomics. Our aim was to identify the optimal radiomics-based machine learning method for isocitrate dehydrogenase (IDH) genotype prediction in diffuse gliomas.

Methods: Eight classical machine learning methods were evaluated in terms of their stability and performance for pre-operative IDH genotype prediction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2787-1DOI Listing

Serum miR-16 as a potential biomarker for human cancer diagnosis: results from a large-scale population.

J Cancer Res Clin Oncol 2019 Mar 31;145(3):787-796. Epub 2019 Jan 31.

Department of Oncology, The Affiliated Hospital of Jiangnan University, 200 Huihe Road, Wuxi, 214062, China.

Background: Cancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02849-8DOI Listing

NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance.

J Cancer Res Clin Oncol 2019 Jan 30. Epub 2019 Jan 30.

Unit of Radiation Oncology, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Purpose: Tumor cells generally exhibit higher levels of reactive oxygen species (ROS), however, when stressed, tumor cells can undergo a process of 'Redox Resetting' to acquire a new redox balance with stronger antioxidant systems that enable cancer cells to become resistant to radiation therapy (RT). Here, we describe how RT affects the oxidant/antioxidant balance in human embryonal (RD) and alveolar (RH30) rhabdomyosarcoma (RMS) cell lines, investigating on the molecular mechanisms involved.

Methods: Radiations were delivered using an x-6 MV photon linear accelerator and their effects were assessed by vitality and clonogenic assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02851-0DOI Listing
January 2019
1 Read

Mistletoe in oncological treatment: a systematic review : Part 1: survival and safety.

J Cancer Res Clin Oncol 2019 Mar 23;145(3):695-707. Epub 2019 Jan 23.

Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.

Purpose: Mistletoe treatment of cancer patients is discussed highly controversial in the scientific literature. Aim of this systematic review is to give an extensive overview about current state of research concerning mistletoe therapy of oncologic patients regarding survival, quality of life and safety.

Methods: In September and October 2017 Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, CINAHL and "Science Citation Index Expanded" (Web of Science) were systematically searched. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-02837-4
Publisher Site
http://dx.doi.org/10.1007/s00432-018-02837-4DOI Listing
March 2019
4 Reads

Mistletoe in oncological treatment: a systematic review : Part 2: quality of life and toxicity of cancer treatment.

J Cancer Res Clin Oncol 2019 Jan 23. Epub 2019 Jan 23.

Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.

Purpose: One important goal of any cancer therapy is to improve or maintain quality of life. In this context, mistletoe treatment is discussed to be highly controversial. The aim of this systematic review is to give an extensive overview about the current state of evidence concerning mistletoe therapy of oncologic patients regarding quality of life and side effects of cancer treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02838-3DOI Listing
January 2019

Comparative analysis of co-occurring mutations of specific tumor suppressor genes in lung adenocarcinoma between Asian and Caucasian populations.

J Cancer Res Clin Oncol 2019 Mar 23;145(3):747-757. Epub 2019 Jan 23.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China.

Introduction: Mutated tumor suppressor genes (TSG) such as TP53, STK11, and MGA are widely-reported. We hypothesized the presence of single mutation or co-occurring mutations in these specific genes may represent a significant therapeutic target for lung adenocarcinoma.

Methods: We sequenced lung adenocarcinoma samples from 677 East-Asian patients, combined them with those from cBioPortal public database (including TCGA) and performed a comparative analysis between Asian and Caucasian populations. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-02828-5
Publisher Site
http://dx.doi.org/10.1007/s00432-018-02828-5DOI Listing
March 2019
2 Reads
3.081 Impact Factor

Combining immunotherapy and natural immune stimulants: mechanisms and clinical implications.

J Cancer Res Clin Oncol 2019 Jan 23. Epub 2019 Jan 23.

Program on Integrative Medicine, Department of Physical Medicine and Rehabilitation, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02830-xDOI Listing
January 2019
1 Read

ePROs in the follow-up of cancer patients treated with immune checkpoint inhibitors: a retrospective study.

J Cancer Res Clin Oncol 2019 Mar 21;145(3):765-774. Epub 2019 Jan 21.

Department of Oncology and Radiotherapy, Oulu University Hospital (OYS), MRC Oulu, P.B. 22, 90029, Oulu, Finland.

Purpose: Patient-reported outcome (PRO) follow-up has been shown to improve quality of life (QoL) and survival of cancer patients receiving chemotherapy. Kaiku Health application is a web-based electronic PRO (ePRO) tool which is designed for follow-up of cancer patients receiving immune checkpoint inhibitors (ICI). Purpose of the current study is to investigate whether symptoms collected by Kaiku Health ePRO tool on cancer patients receiving immune checkpoint inhibitors (ICI) follows to symptoms reported in clinical trials and whether coupling of specific symptoms does occur. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02835-6DOI Listing
March 2019
4 Reads

GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway.

J Cancer Res Clin Oncol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai, 200032, China.

Purpose: Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer. Gefitinib is one of the most accepted therapies against NSCLC in those carrying EGFR mutations, but it is only effective in approximately 20% of patients with NSCLC. Thus, alternative therapeutic interventions are urgently needed to overcome gefitinib resistance. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-019-02845-y
Publisher Site
http://dx.doi.org/10.1007/s00432-019-02845-yDOI Listing
January 2019
9 Reads

Expression of cancer-testis antigens in esophageal cancer and their progress in immunotherapy.

J Cancer Res Clin Oncol 2019 Feb 17;145(2):281-291. Epub 2019 Jan 17.

Department of Oncology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.

Purpose: Esophageal cancer is a common disease in China with low survival rate due to no obvious early symptoms and lack of effective screening strategies. Traditional treatments usually do not produce desirable results in patients with advanced esophageal cancer, so immunotherapy which relies on tumor-related antigens is needed to combat low survival rates effectively. Cancer-testis antigens (CTA), a large family of tumor-related antigens, have a strong in vivo immunogenicity and tumor-restricted expressing patterns in normal adult tissues. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-019-02840-3
Publisher Site
http://dx.doi.org/10.1007/s00432-019-02840-3DOI Listing
February 2019
5 Reads

Effects of metabolic syndrome on the prevalence of prostate cancer: historical cohort study using the national health insurance service database.

J Cancer Res Clin Oncol 2019 Mar 17;145(3):775-780. Epub 2019 Jan 17.

Department of Urology, Seoul National University Boramae Medical Center, Sindaebang 2(i)-dong, Dongjak-gu, Seoul, 07061, Republic of Korea.

Purpose: To estimate the effect of metabolic syndrome (MetS) on the prevalence of prostate cancer using a large retrospective cohort with a 5-year follow-up duration.

Methods: National Health Insurance Service health checkup cohort was used for the study. In total, 130,342 men included in the health checkup cohort in 2009 were divided into two groups according to the presence of prostate cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02842-1DOI Listing

ZWINT is the next potential target for lung cancer therapy.

J Cancer Res Clin Oncol 2019 Mar 14;145(3):661-673. Epub 2019 Jan 14.

Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, People's Republic of China.

Purpose: We aimed to analyze the expression of ZWINT, NUSAP1, DLGAP5, and PRC1 in tumor tissues and adjacent tissues with public data.

Methods: The expression patterns of four genes were detected in cancer tissues and adjacent tissues by qRT-PCR. The overall survival analysis was used to explore these genes in lung adenocarcinoma and squamous cell carcinoma patients. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-2823-1
Publisher Site
http://dx.doi.org/10.1007/s00432-018-2823-1DOI Listing
March 2019
7 Reads

Pre-orchiectomy tumor marker levels should not be used for International Germ Cell Consensus Classification (IGCCCG) risk group assignment.

J Cancer Res Clin Oncol 2019 Mar 14;145(3):781-785. Epub 2019 Jan 14.

Department of Urology, University Hospital, University of Zurich, Zurich, Switzerland.

Purpose: To investigate whether the use of pre-orchiectomy instead of pre-chemotherapy tumor marker (TM) levels has an impact on the International Germ Cell Consensus Classification (IGCCCG) risk group assignment in patients with metastatic germ cell tumors (GCT).

Methods: Demographic and clinical information of all patients treated for primary metastatic testicular non-seminomatous GCT in our tertiary care academic center were extracted from medical charts. IGCCCG risk group assignment was correctly performed with pre-chemotherapy marker levels and additionally with pre-orchiectomy marker levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02844-zDOI Listing
March 2019
1 Read

Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma.

J Cancer Res Clin Oncol 2019 Jan 11. Epub 2019 Jan 11.

Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Yanagido, Gifu, 501-1193, Japan.

Purpose: Cleft palate transmembrane protein 1 (Clptm1) and its paralog protein, Cisplatin resistance-related protein 9 (CRR9) constitute a highly conserved protein family, from Caenorhabditis elegans to Homo sapiens. In the present study, we examined the clinicopathological and biological significance of Clptm1 and CRR9 expression in oral squamous cell carcinoma (OSCC).

Methods: Ninety-eight OSCC tissue specimens were immunohistochemically stained with specific antibodies to Clptm1 and CRR9. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-019-02843-0
Publisher Site
http://dx.doi.org/10.1007/s00432-019-02843-0DOI Listing
January 2019
2 Reads

The anticancer effects and mechanisms of fucoxanthin combined with other drugs.

J Cancer Res Clin Oncol 2019 Feb 9;145(2):293-301. Epub 2019 Jan 9.

Department of Rehabilitation, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, HanZheng Street 473, QiaoKou District, Wuhan, 430030, China.

Purpose: Fucoxanthin (Fx) is a characteristic carotenoid present in brown seaweed that has been shown to have various benefits, including anticancer effects. In vitro studies demonstrated these various effects, including the suppression of cell viability, the promotion of apoptosis, and antiangiogenic, antiproliferative, and antimetastatic activity. Interestingly, combinations of Fx with other drugs have better effects than either Fx or other drugs alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02841-2DOI Listing
February 2019

Immune checkpoint blockade for Merkel cell carcinoma: actual findings and unanswered questions.

J Cancer Res Clin Oncol 2019 Feb 7;145(2):429-443. Epub 2019 Jan 7.

Department of Clinical Medicine and Surgery, University "Federico II", Naples, Italy.

Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine carcinoma arising from the skin. We aimed to review and deal with some of the most relevant controversial topics on the correct use of immunotherapy for the treatment of MCC.

Methods: The primary search was carried out via PubMed, EMBASE, and the Cochrane Library (until 31st May, 2018), while other articles and guidelines were retrieved from related papers or those referenced in these papers. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-019-02839-w
Publisher Site
http://dx.doi.org/10.1007/s00432-019-02839-wDOI Listing
February 2019
1 Read

High frequency of H3 K27M mutations in adult midline gliomas.

J Cancer Res Clin Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076, Tuebingen, Germany.

Purpose: Diffuse midline gliomas, H3 K27M-mutant were introduced as a new grade IV entity in WHO classification of tumors 2016. These tumors occur often in pediatric patients and show an adverse prognosis with a median survival less than a year. Most of the studies on these tumors, previously known as pediatric diffuse intrinsic pontine glioma, are on pediatric patients and its significance in adult patients is likely underestimated. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-02836-5
Publisher Site
http://dx.doi.org/10.1007/s00432-018-02836-5DOI Listing
January 2019
15 Reads

Computer-assisted medical image classification for early diagnosis of oral cancer employing deep learning algorithm.

J Cancer Res Clin Oncol 2019 Jan 3. Epub 2019 Jan 3.

Department of Electrical and Electronics Engineering, Mepco Schlenk Engineering College (Autonomous), Sivakasi, Tamil Nadu, India.

Purpose: Oral cancer is a complex wide spread cancer, which has high severity. Using advanced technology and deep learning algorithm early detection and classification are made possible. Medical imaging technique, computer-aided diagnosis and detection can make potential changes in cancer treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02834-7DOI Listing
January 2019

FTIR-based spectrum of salivary exosomes coupled with computational-aided discriminating analysis in the diagnosis of oral cancer.

J Cancer Res Clin Oncol 2019 Mar 3;145(3):685-694. Epub 2019 Jan 3.

Department of Oral Pathology and Oral Medicine, School of Dentistry, Tel Aviv University, 69978, Tel Aviv, Israel.

Purpose: To determine the Fourier-transform infrared (FTIR) spectra of salivary exosomes from oral cancer (OC) patients and healthy individuals (HI) and to assess its diagnostic potential using computational-aided models.

Methods: Whole saliva samples were collected from 21 OC patients and 13 HI. Exosomes were pelleted using differential centrifugation (12,000g, 120,000g). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-02827-6
Publisher Site
http://dx.doi.org/10.1007/s00432-018-02827-6DOI Listing
March 2019
3 Reads

Differential molecular pathways expression in HER2 positive early breast cancer according to hormone receptor status.

J Cancer Res Clin Oncol 2019 Jan 2. Epub 2019 Jan 2.

Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena, Via del Pozzo 71, 41122, Modena, Italy.

Purpose: Hormone receptors (HR) status in HER2 + breast cancer (BC) is a recognized stratification factor with relevant clinical implication. According to HR expression, HER2 + BC show different clinical characteristics, treatment sensitivity and prognosis. The interaction between HR and HER2 pathways remains incompletely understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02833-8DOI Listing
January 2019
1 Read
3.081 Impact Factor

FDG PET/CT to predict the curability of endoscopic resection for early gastric cancer.

J Cancer Res Clin Oncol 2019 Mar 2;145(3):759-764. Epub 2019 Jan 2.

Department of Nuclear Medicine, Seoul Medical Center, 156 Sinnae-ro, Jungnang-gu, Seoul, South Korea.

Purpose: We evaluated the value of fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) as a complementary imaging modality to endoscopy to predict the curability of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC).

Methods: The institutional review board approved this retrospective study with a waiver of informed consent. The records of patients who underwent FDG PET/CT for initial routine staging of gastric cancer from January 2012 to October 2017 were reviewed retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02832-9DOI Listing
March 2019
1 Read

Impact of the homogeneous and heterogeneous risk factors on the incidence and survival outcome of bone metastasis in NSCLC patients.

J Cancer Res Clin Oncol 2019 Mar 2;145(3):737-746. Epub 2019 Jan 2.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, No. 270 Dong-An Road, Shanghai, 200032, China.

Purpose: Bone metastases (BM) is reported as the most frequent distant metastasis in non-small cell lung cancer (NSCLC), but the risk factors for the incidence and prognosis of BM patients in NSCLC have not been extensively elucidated. This study aimed to find risk factors to predict BM patients' morbidity and survival outcome in NSCLC.

Methods: 63,505 patients of NSCLC in the Surveillance, Epidemiology and End Results database diagnosed from 2010 to 2015 were used to analyze risk factors for developing BM by conducting multivariable logistic regression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02826-7DOI Listing
March 2019
1 Read

A three-gene methylation marker panel for the nodal metastatic risk assessment of muscle-invasive bladder cancer.

J Cancer Res Clin Oncol 2019 Jan 2. Epub 2019 Jan 2.

Department of Urology and Pediatric Urology, Saarland University, Kirrberger Strasse, 66421, Homburg/saar, Germany.

Purpose: In this study, we aimed to identify a DNA methylation pattern suitable for prognosis assessment of muscle-invasive bladder cancer and to investigate metastasis-associated processes regulated by DNA methylation.

Methods: Genome-wide methylation analysis was performed on 23 muscle-invasive bladder tumors by microarray analysis. Validation was performed by the qAMP technique in two different patient cohorts (n = 32 and n = 100). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-02829-4
Publisher Site
http://dx.doi.org/10.1007/s00432-018-02829-4DOI Listing
January 2019
6 Reads

Identification of myeloid-derived suppressor cells that have an immunosuppressive function in NF2 patients.

J Cancer Res Clin Oncol 2019 Feb 2;145(2):523-533. Epub 2019 Jan 2.

Beijing Neurosurgical Institute, Capital Medical University, No. 6, Tiantan Xili, Chongwen District, Beijing, 100050, China.

Purpose: There is no targeted drug therapy for NF2 patients, and surgery or radiosurgery is not always effective. Therefore, the exploration of new therapeutic pathways is urgently needed.

Methods: We analyzed the expression of cytokines in the serum of NF2 patients and determined the percentage of HLA-DRCD33CD11b cells in blood and NF2-associated schwannomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02825-8DOI Listing
February 2019
1 Read

Prognostic value of initial bone marrow disease detection by multiparameter flow cytometry in children with neuroblastoma.

J Cancer Res Clin Oncol 2019 Feb 2;145(2):535-542. Epub 2019 Jan 2.

Research Institute of Medical Cell Technologies, 22A, K. Marx st, Yekaterinburg, 620026, Russian Federation.

Purpose: Multicolor flow cytometry (MFC) is widely available, fast and has an easy-to perform approach for finding neuroblastoma (NB) cells among normal bone marrow (BM) hematopoietic cells. Aim of the study was to investigate prognostic significance of initial MFC tumor cells' detection in BM of children with NB.

Methods: 51 patients (24 boys and 27 girls) aged from 6 days to 15 years (median age 1 year 3 months) with NB were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-02831-wDOI Listing
February 2019

Prognostic relevance of low-grade versus high-grade FIGO IB1 squamous cell uterine cervical carcinomas.

J Cancer Res Clin Oncol 2019 Feb 2;145(2):457-462. Epub 2019 Jan 2.

Department of Obstetrics and Gynecology, Technical University Munich, Munich, Germany.

Purpose: Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix.

Methods: Histologic slides of 233 surgically treated cervical SCC (FIGO IB1) were re-examined regarding the prognostic impact of the WHO-based grading system, using the different degree of keratinization, categorizing the tumors in G1, G2 and G3 (conventional tumor grade).

Results: 45. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2793-3DOI Listing
February 2019
1 Read

A novel histologic grading system based on lymphovascular invasion, perineural invasion, and tumor budding in colorectal cancer.

J Cancer Res Clin Oncol 2019 Feb 2;145(2):471-477. Epub 2019 Jan 2.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Purpose: This study aimed to evaluate the prognostic significance of lymphovascular (LVI), perineural invasion (PNI), and tumor budding positivity in patients with colorectal cancer.

Methods: From January 2008 to December 2011, 3707 consecutive patients who underwent curative surgery for stage I-III colorectal cancer were assessed. These patients were then categorized into four groups based on LVI, PNI, and tumor budding (risk grouping): all negative (n = 1495), 1 + only (n = 1063), 2 + only (n = 861), and all positive (n = 288). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2804-4DOI Listing
February 2019

LncRNA GAS5 regulates redox balance and dysregulates the cell cycle and apoptosis in malignant melanoma cells.

J Cancer Res Clin Oncol 2019 Mar 19;145(3):637-652. Epub 2018 Dec 19.

Department of Biochemistry and Molecular Biology, Kunming Medical University, No. 1168 Yuhua Road, Chenggong District, Kunming, 650500, Yunnan, China.

Purpose: Clinical outcomes for advanced malignant melanoma (MM) are often poor due to tumor invasiveness, metastasis, recurrence, and multidrug resistance.

Methods: We investigated whether apoptosis, cell cycle regulation, oxidative status, and redox balance were altered by changes in the expression of the long noncoding RNA, growth arrest-specific transcript 5 (GAS5), in MM cells.

Results: Analysis of clinical samples from MM patients showed that the rate of reduced GAS5 expression, relative to that in adjacent noncancerous tissues, was significantly lower for tumors from patients with advanced disease (76. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2820-4DOI Listing

Identification of genes and pathways, including the CXCL2 axis, altered by DNA methylation in hepatocellular carcinoma.

J Cancer Res Clin Oncol 2019 Mar 18;145(3):675-684. Epub 2018 Dec 18.

Department of Systems Biology, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.

Purpose: Recent genetic studies have suggested that tumor suppressor genes are often silenced during carcinogenesis via epigenetic modification caused by methylation of promoter CpG islands. Here, we characterized genes inactivated by DNA methylation in human hepatocellular carcinoma (HCC) to identify the genes and pathways involved in DNA methylation in hepatocellular carcinoma.

Methods: Eight HCC-derived cell lines were treated with a DNA demethylating agent, 5-aza-2'-deoxycytidine. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-2824-0
Publisher Site
http://dx.doi.org/10.1007/s00432-018-2824-0DOI Listing
March 2019
5 Reads

Fecal volatile organic compounds for early detection of colorectal cancer: where are we now?

J Cancer Res Clin Oncol 2019 Jan 15;145(1):223-234. Epub 2018 Dec 15.

Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Amsterdam, AG&M Research Institute, Amsterdam, The Netherlands.

Introduction: The fecal volatolome, which is composed of fecal volatile organic compounds (VOCs), seems to hold potential as non-invasive biomarker for the detection of colorectal cancer (CRC) and its precursor lesions advanced adenomas (AA). The potential of the fecal volatolome has been subject of various studies using either chemical analytical or pattern-recognition techniques. The available literature on the potential of the fecal volatolome as CRC and AA biomarker was reviewed. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-2821-3
Publisher Site
http://dx.doi.org/10.1007/s00432-018-2821-3DOI Listing
January 2019
8 Reads

Increasing trends in in situ breast cancer incidence in a region with no population-based mammographic screening program: results from Zurich, Switzerland 2003-2014.

J Cancer Res Clin Oncol 2019 Mar 13;145(3):653-660. Epub 2018 Dec 13.

Division of Chronic Disease Epidemiology, Institute for Epidemiology, Biostatistics and Prevention, University of Zurich, Hirschengraben 82, 8001, Zurich, Switzerland.

Purpose: Increase in in situ breast cancer (BCIS) incidence has been reported across Europe and the USA. However, little is known about the trends in BCIS incidence in regions without population-based mammographic screening programs. We set out to investigate these trends in Zurich, Switzerland, where only opportunistic mammographic screening exists. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-2822-2
Publisher Site
http://dx.doi.org/10.1007/s00432-018-2822-2DOI Listing
March 2019
8 Reads

Melanoma tumour vasculature heterogeneity: from mice models to human.

J Cancer Res Clin Oncol 2019 Mar 13;145(3):589-597. Epub 2018 Dec 13.

UMR Inserm 1066, CNRS 6021, Université d'Angers, CHU, IBS, IRIS, MINT, UNIV Angers, INSERM, CNRS, Université Bretagne Loire, IBS-CHU, 4, rue Larrey, 49933, Angers, France.

Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascular structure in different mouse models of melanoma tumours (B16F10 and SK-Mel-28) and in human melanomas from different patients. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-2809-z
Publisher Site
http://dx.doi.org/10.1007/s00432-018-2809-zDOI Listing
March 2019
14 Reads
3.081 Impact Factor

Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (version 2018).

J Cancer Res Clin Oncol 2019 Mar 12;145(3):725-736. Epub 2018 Dec 12.

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

The liver is the most common anatomical site for hematogenous metastases of colorectal cancer, and colorectal liver metastases is one of the most difficult and challenging points in the treatment of colorectal cancer. To improve the diagnosis and comprehensive treatment in China, the Guidelines have been edited and revised several times since 2008, including the overall evaluation, personalized treatment goals and comprehensive treatments, to prevent the occurrence of liver metastases, improve the resection rate of liver metastases and survival. The revised Guideline includes the diagnosis and follow-up, prevention, MDT effect, surgery and local ablative treatment, neoadjuvant and adjuvant therapy, and comprehensive treatment, and with advanced experience, latest results, detailed content, and strong operability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2795-1DOI Listing

TP53 mutations as potential prognostic markers for specific cancers: analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 Database.

J Cancer Res Clin Oncol 2019 Mar 12;145(3):625-636. Epub 2018 Dec 12.

Department of Science, The Wheatley School, Old Westbury, NY, USA.

Purpose: Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers.

Methods: Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP53 Database were analyzed to determine the distribution of germline and somatic mutations in the TP53 gene. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-2817-z
Publisher Site
http://dx.doi.org/10.1007/s00432-018-2817-zDOI Listing
March 2019
2 Reads

Microbiota in cancer development and treatment.

J Cancer Res Clin Oncol 2019 Jan 12;145(1):49-63. Epub 2018 Dec 12.

Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.

Purpose: Human microbiota comprises of a variety of organisms ranging from bacterial species to viruses, fungi, and protozoa which are present on the epidermal and mucosal barriers of the body. It plays a key role in health and survival of the host by regulation of the systemic functions. Its apparent functions in modulation of the host immune system, inducing carcinogenesis and regulation of the response to the cancer therapy through a variety of mechanisms such as bacterial dysbiosis, production of genotoxins, pathobionts, and disruption of the host metabolism are increasingly becoming evident. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2816-0DOI Listing
January 2019
2 Reads
3.081 Impact Factor

Effect of the botanical formula LCS101 on the anti-cancer effects of radiation therapy.

J Cancer Res Clin Oncol 2019 Mar 6;145(3):609-613. Epub 2018 Dec 6.

Institute of Oncology, Sheba Medical Center, Tel Hashomer, Israel.

Background And Purpose: The botanical formula LCS101 has been shown in clinical research to reduce chemotherapy-induced toxicities. In pre-clinical research, the formula demonstrated selective anti-cancer effects, in part as a result of radical oxygen species (ROS) activity of the botanical components. The present study examined the interaction between LCS101 and radiation therapy on cancer cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2812-4DOI Listing
March 2019
1 Read

Gynecologic radiation oncology patients report unmet needs regarding sexual health communication with providers.

J Cancer Res Clin Oncol 2019 Feb 11;145(2):495-502. Epub 2018 Dec 11.

Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: Following radiation therapy (RT), women with gynecologic malignancies report high rates of sexual dysfunction, but little is known regarding sexual health communication between these patients and health-care providers. This study assessed these patients' beliefs/attitudes toward providers' sexual history taking.

Methods: Surveys were administered to women who presented for follow-up care for gynecologic cancers in an academic radiation oncology department. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2813-3DOI Listing
February 2019
1 Read

Evaluation of the effects of intra-arterial chemotherapy combined with intravesical chemotherapy against intravesical chemotherapy alone after transurethral resection of bladder tumor in T1-staged Grade 3 bladder cancer.

J Cancer Res Clin Oncol 2019 Feb 11;145(2):487-494. Epub 2018 Dec 11.

Department of Urology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou, 510080, China.

Objective: Comparing intra-arterial chemotherapy combined with intravesical chemotherapy against intravesical chemotherapy alone in the treatment of T1-staged Grade 3 (T1G3) bladder cancer after transurethral resection of bladder tumor (TURBT).

Materials And Methods: From January 2007 to December 2012, 203 patients diagnosed with NMIBC were randomly assigned into either intra-arterial chemotherapy combined with intravesical chemotherapy group (Group A, n = 68) or intravesical chemotherapy alone group (Group B, n = 135) after TURBT. Four cycles of intra-arterial chemotherapy were administered after initial TURBT with 1-month interval between each. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2811-5DOI Listing
February 2019
1 Read
3.081 Impact Factor

Immune-related adverse events correlate with improved survival in patients undergoing anti-PD1 immunotherapy for metastatic melanoma.

J Cancer Res Clin Oncol 2019 Feb 11;145(2):511-521. Epub 2018 Dec 11.

Melanoma Medical Oncology Unit, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, 20133, Milan, Italy.

Background: Therapeutic chances for metastatic melanoma have consistently changed over the last years with the advent of antibodies targeting the programmed cell death protein-1 (PD-1). Onset of immune-related adverse events (irAEs) during treatment can be a source of concern, and the association with survival outcome is yet to be defined.

Patients And Methods: Data of consecutive patients treated with anti-PD1 (nivolumab or pembrolizumab) for metastatic melanoma between July 2013 and January 2018 were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2819-xDOI Listing
February 2019

T-cell receptor-α CDR3 domain chemical features correlate with survival rates in bladder cancer.

J Cancer Res Clin Oncol 2019 Mar 11;145(3):615-623. Epub 2018 Dec 11.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.

Purpose: In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lymphocyte (TIL)-based therapies and other immunotherapies.

Methods: The immune receptor complementarity determining region-3 (CDR3) is considered to be important for antigen binding, hence, in this report, we evaluated the chemical features of the CDR3 of 846 T-cell receptor-α (TCR-α) coding regions associated with bladder tumor tissue, using bioinformatics databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2815-1DOI Listing

Stuttering as the first sign of CAR-T-cell-related encephalopathy syndrome (CRES).

J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital Cancer Center, 55 Fruit Street Yawkey Center Suite 9E, Boston, MA, 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-018-2818-yDOI Listing
December 2018
3.081 Impact Factor