5,827 results match your criteria Journal of cancer research and clinical oncology[Journal]


Assessment of concomitant non-oncologic medication in patients with surgically treated renal cell carcinoma: impact on prognosis, cell-cycle progression and proliferation.

J Cancer Res Clin Oncol 2019 Apr 22. Epub 2019 Apr 22.

Department of Urology, Eberhard Karls University, Hoppe-Seyler- Strasse 3, 72076, Tuebingen, Germany.

Introduction: Based on the observation of beneficial effects on cancer metabolism, microenvironment, or VEGF-signaling, several non-anticancer drugs have been discussed as useful in renal cell carcinoma (RCC). In the present study, we investigated the prognostic impact of concomitant medication in RCC and correlated comedication with cell-cycle and proliferation activity in corresponding surgical specimen.

Methods: A total of 388 patients who underwent surgery for localized RCC were included. Read More

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http://dx.doi.org/10.1007/s00432-019-02914-2DOI Listing

Focal adhesion kinase (FAK) phosphorylation is a key regulator of embryonal rhabdomyosarcoma (ERMS) cell viability and migration.

J Cancer Res Clin Oncol 2019 Apr 21. Epub 2019 Apr 21.

Department of Biochemistry and Molecular Biology, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.

Background: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. Pathogenesis of RMS is associated with aggressive growth pattern and increased risk of morbidity and mortality. There are two main subtypes or RMS: embryonal and alveolar. Read More

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http://dx.doi.org/10.1007/s00432-019-02913-3DOI Listing

Research driving innovation: what are key factors for successful integration of translational science into oncology care concepts? 5th European Roundtable Meeting (ERTM) May 4th, 2018, Berlin, Germany.

J Cancer Res Clin Oncol 2019 Apr 16. Epub 2019 Apr 16.

German Cancer Society, Berlin, Germany.

Purpose: To identify key factors for successful integration of translational science into cancer care.

Results: Organisation of the health care system matters to optimally bridge between public and private cancer research, cancer registries and routine care. Currently, there are deficits on various levels of connectivity. Read More

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http://link.springer.com/10.1007/s00432-019-02916-0
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http://dx.doi.org/10.1007/s00432-019-02916-0DOI Listing
April 2019
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Patient-reported outcomes in the phase 3 BFORE trial of bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia.

J Cancer Res Clin Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of Hematology and Oncology, Universitätsklinikum RWTH Aachen, Aachen, Germany.

Background: In the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML). Assessment of patient-reported outcomes (PROs) was an exploratory objective.

Methods: Patients with newly diagnosed CP CML were randomized 1:1 to receive once-daily bosutinib 400 mg or imatinib 400 mg as first-line therapy. Read More

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http://link.springer.com/10.1007/s00432-019-02894-3
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http://dx.doi.org/10.1007/s00432-019-02894-3DOI Listing
April 2019
1 Read
3.081 Impact Factor

Clinical impact of PD-L1 and PD-1 expression in squamous cell cancer of the vulva.

J Cancer Res Clin Oncol 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology, University Hospital of Cologne, Institute of Pathology, Kerpener Str. 62, 50937, Cologne, Germany.

Purpose: Squamous cell carcinoma of the vulva (SQCV) is the fifth most common cancer in women and accounts for about 5% of all genital cancers in women. The PD-L1 signaling pathway is activated in many malignant neoplasms and its blockade enhances anti-cancer immunity. The aim of our study was to examine the protein expression of PD-L1 and PD-1 in squamous cell cancer of the vulva, its correlations with clinicopathologic features and prognostic value. Read More

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http://dx.doi.org/10.1007/s00432-019-02915-1DOI Listing

Molecular and cellular adaptations to exercise training in skeletal muscle from cancer patients treated with chemotherapy.

J Cancer Res Clin Oncol 2019 Apr 9. Epub 2019 Apr 9.

Research Laboratory for Biochemical Pathology, Department of Clinical Medicine, HEALTH, Aarhus University Hospital, Palle Juul-Jensen Blvd., 8200, Aarhus N, Denmark.

Background: A growing body of evidence suggests that exercise training has beneficial effects in cancer patients. The aim of the present study was to investigate the molecular basis underlying these beneficial effects in skeletal muscle from cancer patients.

Methods: We investigated expression of selected proteins involved in cellular processes known to orchestrate adaptation to exercise training by western blot. Read More

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http://dx.doi.org/10.1007/s00432-019-02911-5DOI Listing
April 2019
4 Reads

The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer.

J Cancer Res Clin Oncol 2019 Apr 8. Epub 2019 Apr 8.

Department of Transfusion Medicine, Huashan Hospital, Fudan University, 12 Urumqi Middle Road, Shanghai, 200040, People's Republic of China.

Purpose: During the past decades, PD-1/PD-L1 axis blockade has become a remarkable promising therapy which has exerted durable anti-tumor effect and long-term remissions on part of cancers. However, there are still some patients which do not show good response to the PD-1/PD-L1 targeted monotherapy. Till now, the widely accepted anti-tumor mechanism of PD-1/PD-L1 blockade is rejuvenating T cells, there is lack of studies which focus on other components of the tumor environment in the treatment of cancer with PD-1/PD-L1 blockade, especially the complicated relationship between macrophages and PD-1/PD-L1 pathway during the progression and treatment of cancer. Read More

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http://dx.doi.org/10.1007/s00432-019-02879-2DOI Listing
April 2019
3.081 Impact Factor

Risk group-adapted adjuvant radiotherapy for WHO grade I and II skull base meningioma.

J Cancer Res Clin Oncol 2019 Apr 5. Epub 2019 Apr 5.

Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonju-ro, Gangnam-gu, Seoul, 06273, South Korea.

Purpose: Salvage treatment including surgery and radiotherapy (RT) for recurrent or progressive meningioma is not an easy task, especially for the skull base location. And yet, criteria for adjuvant radiotherapy after initial surgery are not clearly defined for WHO grade I/II meningioma. We determined prognostic factors for recurrence and evaluated the benefit of risk group-adapted adjuvant RT for WHO grade I/II meningioma in the skull base. Read More

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http://dx.doi.org/10.1007/s00432-019-02891-6DOI Listing
April 2019
2 Reads

Results of the European survey on the assessment of deep molecular response in chronic phase CML patients during tyrosine kinase inhibitor therapy (EUREKA registry).

J Cancer Res Clin Oncol 2019 Apr 2. Epub 2019 Apr 2.

Abteilung Hämatologie und Internistische Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena, Am Klinikum 1, 07740, Jena, Germany.

Purpose: The advent of tyrosine kinase inhibitor (TKI) therapies has revolutionized the treatment of chronic myeloid leukemia (CML). The European LeukemiaNet (ELN) recommends quantification of BCR-ABL1 transcripts by real-time quantitative PCR every 3 months during TKI treatment. Since a proportion of patients in deep molecular response (DMR: MR, MR, MR) maintain remission after treatment stop, assessment of DMR is crucial. Read More

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http://dx.doi.org/10.1007/s00432-019-02910-6DOI Listing
April 2019
1 Read

Alternative and canonical NF-kB pathways DNA-binding hierarchies networks define Hodgkin lymphoma and Non-Hodgkin diffuse large B Cell lymphoma respectively.

J Cancer Res Clin Oncol 2019 Apr 2. Epub 2019 Apr 2.

Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB), CONICET-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires, Potosí 4240 C.P., C1183AEG, Buenos Aires, Argentina.

Purpose: Despite considerable evidence that supports the NF-kB role in the immune system and lymphomagenesis, it is unclear whether specific NF-kB dimers control a particular set of genes that account for their biological functions. Our previous work showed that Hodgkin Lymphoma (HL) is unique, among germinal center (GC)-derived lymphomas, with respect to its dependency on Rel-B to survive. In contrast, diffuse large B-Cell lymphoma (DLBCL) including both Activated B-Cell-Like and Germinal Center B-Cell-Like, requires cREL and Rel-A to survive and it is not affected by Rel-B depletion. Read More

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http://dx.doi.org/10.1007/s00432-019-02909-zDOI Listing
April 2019
3 Reads

Predicting the risk of locoregional recurrence after early breast cancer: an external validation of the Dutch INFLUENCE-nomogram with clinical cancer registry data from Germany.

J Cancer Res Clin Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

Purpose: Follow-up after breast cancer treatment aims for an early detection of locoregional breast cancer recurrences (LRR) to improve the patients' outcome. By estimating individual's 5-year recurrence-risks, the Dutch INFLUENCE-nomogram can assist health professionals and patients in developing personalized risk-based follow-up pathways. The objective of this study is to validate the prediction tool on non-Dutch patients. Read More

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http://dx.doi.org/10.1007/s00432-019-02904-4DOI Listing

Impact of 9q deletions on the classification of patients with acute myeloid leukemia.

J Cancer Res Clin Oncol 2019 Mar 29. Epub 2019 Mar 29.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00432-019-02908-0DOI Listing
March 2019
1 Read

ALDH1 expression correlates with an epithelial-like phenotype and favorable prognosis in lung adenocarcinoma: a study based on immunohistochemistry and mRNA expression data.

J Cancer Res Clin Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Suwon, Republic of Korea.

Purpose: Cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT) pathways are crucial for cancer progression. However, synergistic interactions between CSC and EMT are not clear in non-small cell lung cancer (NSCLC). The objective of this study was to investigate CSC markers such as CD44, NANOG, and ALDH1 expression and its correlation with EMT markers in NSCLC patients. Read More

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http://dx.doi.org/10.1007/s00432-019-02906-2DOI Listing
March 2019
2 Reads

Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats.

J Cancer Res Clin Oncol 2019 Mar 28. Epub 2019 Mar 28.

Facultad de Biología, Universidad Michoacana de San Nicolás de Hidalgo. Cd. Universitaria, 58030, Morelia, Michoacán, Mexico.

Purpose: Callistemon citrinus (Curtis) Skeels is a shrub native of Australia. In spite of containing an important number of bioactive compounds (1,8-cineole, limonene and α-terpineol) recognized as a potential chemotherapeutic agents, it is only used as an ornamental plant in Mexico. This study investigated the chemopreventive effect of C. Read More

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http://dx.doi.org/10.1007/s00432-019-02905-3DOI Listing
March 2019
1 Read

Gastrointestinal stromal tumors (GISTs) with remarkable cystic change: a specific subtype of GISTs with relatively indolent behaviors and favorable prognoses.

J Cancer Res Clin Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of General Surgery, Zhongshan Hospital, Fudan University, NO. 180 Fenglin Road, Shanghai, 200032, China.

Purpose: Gastrointestinal stromal tumors (GISTs) are typically solid neoplasms with small cystic change detected occasionally but in rare instances may present predominantly as cystic lesions. The histopathologic features and prognoses of cystic GISTs (cGISTs) are poorly understood.

Methods: We herein reviewed 20 cGISTs resected or consulted in our institution from January 1, 2003 to December 31, 2014. Read More

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http://dx.doi.org/10.1007/s00432-019-02853-yDOI Listing
March 2019
1 Read

Circulating microRNAs as biomarkers of radiation-induced cardiac toxicity in non-small-cell lung cancer.

J Cancer Res Clin Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, UH B2 C490 SPC 5010, Ann Arbor, MI, 48109, USA.

Purpose: Radiation-induced cardiac toxicity (RICT) is an increasingly well-appreciated source of morbidity and mortality in patients receiving thoracic radiotherapy (RT). Currently available methods to predict RICT are suboptimal. We investigated circulating microRNAs (c-miRNAs) as potential biomarkers of RICT in patients undergoing definitive RT for non-small-cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1007/s00432-019-02903-5DOI Listing
March 2019
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Comprehensive analysis of the characteristics and treatment outcomes of patients with non-small cell lung cancer treated with anti-PD-1 therapy in real-world practice.

J Cancer Res Clin Oncol 2019 Mar 25. Epub 2019 Mar 25.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.

Purpose: Immune checkpoint inhibitors (ICI) have shown marked responses in patients with non-small cell lung cancer (NSCLC) in clinical trials. However, because such trials comprise cohorts selected based on specific criteria, it is unclear if their results represent routine clinical practice.

Methods: We examined 155 patients with advanced NSCLC who were administered either nivolumab or pembrolizumab at Yonsei Cancer Center, Korea between March 2014 and January 2019. Read More

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http://link.springer.com/10.1007/s00432-019-02899-y
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http://dx.doi.org/10.1007/s00432-019-02899-yDOI Listing
March 2019
4 Reads

Controlling metastatic cancer: the role of phytochemicals in cell signaling.

J Cancer Res Clin Oncol 2019 Mar 22. Epub 2019 Mar 22.

Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine and Martin University Hospital, Comenius University in Bratislava, Martin, Slovakia.

Purpose: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Read More

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http://dx.doi.org/10.1007/s00432-019-02892-5DOI Listing
March 2019
3.081 Impact Factor

NOD1 and NOD2 of the innate immune system is differently expressed in human clear cell renal cell carcinoma, corresponding healthy renal tissue, its vasculature and primary isolated renal tubular epithelial cells.

J Cancer Res Clin Oncol 2019 Mar 22. Epub 2019 Mar 22.

Clinic of Urology and Pediatric Urology, Philipps-University Marburg, Marburg, Germany.

Purpose: NOD1 and NOD2 (nucleotide-binding oligomerization domain)-receptors are intracellular receptors and belong to the family of pattern recognition receptors being present in both human and murine renal tubular cells. Besides, NOD1 has been proved to promote apoptosis, upon its overexpression. Hence, we aimed to investigate NOD1 and NOD2 expression in human clear cell renal cell carcinoma (ccRCC). Read More

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http://dx.doi.org/10.1007/s00432-019-02901-7DOI Listing
March 2019
1 Read

Prognostic significance of metabolic parameters measured by F-FDG PET/CT in limited-stage small-cell lung carcinoma.

J Cancer Res Clin Oncol 2019 Mar 21. Epub 2019 Mar 21.

Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.

Purpose: Metabolic parameters measured by [F]-fluorodeoxyglucose-positron emission tomography/computed tomography (F-FDG PET/CT) are important prognostic factors in several types of cancers. We evaluated the predictive value of tumor metabolic parameters measured by F-FDG PET/CT in limited-disease small-cell lung cancer (LD-SCLC).

Methods: This retrospective study included 30 LD-SCLC patients who underwent standard chemotherapy after radiotherapy with F-FDG PET/CT. Read More

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http://dx.doi.org/10.1007/s00432-019-02848-9DOI Listing
March 2019
2 Reads

Heart myxoma develops oncogenic and metastatic phenotype.

J Cancer Res Clin Oncol 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Bioquímica, Instituto Nacional de Cardiología, Juan Badiano No. 1. Col Sección XVI, Tlalpan, Mexico City, Mexico.

Purpose: Heart myxomas have been frequently considered as benign lesions associated with Carney's complex. However, after surgical removal, myxomas re-emerge causing dysfunctional heart.

Methods: To identify whether cardiac myxomas may develop a metastatic phenotype as occurs in malignant cancers, a profile of several proteins involved in malignancy such as oncogenes (c-MYC, K-RAS and H-RAS), cancer-associated metabolic transcriptional factors (HIF-1α, p53 and PPAR-γ) and epithelial-mesenchymal transition proteins (fibronectin, vimentin, β-catenin, SNAIL and MMP-9) were evaluated in seven samples from a cohort of patients with atrial and ventricular myxomas. Read More

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http://dx.doi.org/10.1007/s00432-019-02897-0DOI Listing
March 2019
1 Read
3.081 Impact Factor

Impact of EGFR mutation on the clinical efficacy of PD-1 inhibitors in patients with pulmonary adenocarcinoma.

J Cancer Res Clin Oncol 2019 Mar 21. Epub 2019 Mar 21.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Purpose: We evaluated the predictive role of EGFR mutation on the efficacy of PD-1/PD-L1 inhibitor therapy in patients with advanced pulmonary adenocarcinoma while considering clinical factors such as PD-L1 expression, gender, and smoking status.

Methods: Patients were required to have available data for EGFR mutation, PD-L1 expression, and efficacy of PD-1/PD-L1 inhibitors.

Results: Among 178 patients with EGFR-mutant (n = 38) or wild-type (WT) (n = 140) tumors, the EGFR mutation group had a lower objective response rate (ORR) (15. Read More

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http://dx.doi.org/10.1007/s00432-019-02889-0DOI Listing
March 2019
1 Read

Intra-arterial chemotherapy combined with intravesical chemotherapy is effective in preventing recurrence in non-muscle invasive bladder cancer.

J Cancer Res Clin Oncol 2019 Mar 21. Epub 2019 Mar 21.

Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou, 510080, China.

Objective: To evaluate the efficacy and safety of intra-arterial chemotherapy (IAC) combined with intravesical chemotherapy (IC) in non-muscle invasive bladder cancer (NMIBC) and identify the risk factors for recurrence and progression.

Methods: This is a retrospective cohort study of NMIBC patients in south China. Ninety-nine patients underwent IAC combined with transurethral resection of bladder tumor (TURBT) and IC, and 50 patients underwent TURBT plus IC without IAC. Read More

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http://dx.doi.org/10.1007/s00432-019-02900-8DOI Listing
March 2019
2 Reads

DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma.

J Cancer Res Clin Oncol 2019 Mar 20. Epub 2019 Mar 20.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

Purpose: Recent studies revealed divergent gene expression patterns in Ewing sarcoma (EwS) with canonical EWSR1-ETS gene fusions and undifferentiated round cell sarcomas (URCS) with EWSR1 rearrangements fused to the non-ETS gene NFATc2. Thus, the question arises whether the latter tumors really belong to EwS.

Methods: We collected five cases matching the group of URCS with EWSR1-NFATc2 fusion and performed DNA methylation and copy number profiling. Read More

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http://dx.doi.org/10.1007/s00432-019-02895-2DOI Listing
March 2019
1 Read
3.081 Impact Factor

Clinical significance of circulatory microRNA-203 in serum as novel potential diagnostic marker for multiple myeloma.

J Cancer Res Clin Oncol 2019 Mar 19. Epub 2019 Mar 19.

Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.

Purpose: Multiple myeloma (MM) is a hematological malignancy marked by uncontrolled proliferation and accumulation of plasma cells in bone marrow. Despite presence of numerous diagnostic markers for MM, their invasive and non-specific nature demands identification of some effective biomarker. Small non-coding RNAs, i. Read More

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http://dx.doi.org/10.1007/s00432-019-02896-1DOI Listing

TRPM2 mediates distruption of autophagy machinery and correlates with the grade level in prostate cancer.

J Cancer Res Clin Oncol 2019 Mar 19. Epub 2019 Mar 19.

Department of Medical Biology, Faculty of Medicine, Firat University, Elazig, Turkey.

Purpose: Transient receptor potential melastatin 2 (TRPM2), a calcium-permeable ion channel, is shown as a prognostic marker candidate in prostate cancer (PCa) and an important regulator of autophagy. We aimed to determine the changes in TRPM2 and autophagic-apoptotic gene expression levels in human prostate adenocarcinomas, and to investigate the affect of TRPM2 on autophagic pathways in PC-3 cell line.

Methods: Human prostate tissues were classified considering the grade levels and were divided into the control, BPH, and grade 1-5 groups. Read More

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http://dx.doi.org/10.1007/s00432-019-02898-zDOI Listing
March 2019
1 Read

Impact of nodal status and treatment strategy on overall survival in advanced stage cervical cancer.

J Cancer Res Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Tumor Center, University of Regensburg, Regensburg, Germany.

Purpose: The lack of prognostic data impedes implementation of optimal therapy for cervical cancer. For instance, recommended therapy for FIGO IIB cervical cancer is radical hysterectomy or radiochemotherapy. To enlighten different therapeutic approaches, we investigated the benefit of individual therapies or combination thereof in patients with or without infested lymph nodes. Read More

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http://dx.doi.org/10.1007/s00432-019-02890-7DOI Listing
March 2019
5 Reads

Twice- vs. thrice-weekly moderate hypofractionated radiotherapy for prostate cancer: does overall treatment time matter?

J Cancer Res Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Radiation Oncology Division, Geneva University Hospital, 1211, Geneva 14, Switzerland.

Purpose: To evaluate the influence of overall treatment time (OTT) in disease control, acute, and long-term side effects with moderate hypofractionated external beam radiotherapy (RT) for prostate cancer (PCa) delivered either twice- or thrice-a-week.

Methods: 157 patients with localized PCa were treated consecutively with 56 Gy in 4 Gy/fraction delivered either twice (86 patients, from 2003 to 2010, group-1) or thrice a week (71 patients, from 2010 to 2017, group-2) using IMRT or VMAT techniques. Gastrointestinal (GI) and genitourinary (GU) toxicities were scored according to the CTCAE v3. Read More

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http://dx.doi.org/10.1007/s00432-019-02893-4DOI Listing
March 2019
1 Read

Autoantibody against 14-3-3 zeta: a serological marker in detection of gastric cancer.

J Cancer Res Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Epidemiology and Health statistics, Henan Key Laboratory for Tumor Epidemiology, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, China.

Purpose: Autoantibody to 14-3-3 zeta was identified in gastric cancer (GC) by serological proteome analysis (SERPA) in our previous study. We comprehensively evaluated its ability to detect GC, determined its association with clinical characteristics, and explored its temporal change in GC patients before and after gastrectomy resection in this study.

Methods: Anti-14-3-3 zeta antibody was examined by immunoassay in sera from 465 GC patients and 465 normal individuals, and also in 69 serial sera from 26 GC patients before and after resection. Read More

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http://link.springer.com/10.1007/s00432-019-02884-5
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http://dx.doi.org/10.1007/s00432-019-02884-5DOI Listing
March 2019
3 Reads

The application of Apc mouse model in colorectal tumor researches.

J Cancer Res Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai, 200433, China.

Purpose: Apc mouse is an excellent animal model bearing multiple intestinal neoplasia, used to simulate human familial adenomatous polyposis and colorectal tumors. The key point of this model is the mutation of Apc gene, which is a significant tumor-suppressor gene in the Wnt signaling pathway. There are also some other possible mechanisms responsible for the development of colorectal tumors in the Apc mouse model, such as tumor-associated signaling pathways activation, the changes of tumor-related genes, and the involvement of some related proteins or molecules. Read More

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http://link.springer.com/10.1007/s00432-019-02883-6
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http://dx.doi.org/10.1007/s00432-019-02883-6DOI Listing
March 2019
5 Reads

Predictors and survival impact of station 4L metastasis in left non-small cell lung cancer.

J Cancer Res Clin Oncol 2019 Mar 16. Epub 2019 Mar 16.

Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Background: It remains unclear about the predictors and survival impact of station 4L metastasis in left-sided non-small cell lung cancer (NSCLC). This study aims to investigate these issues to explore the significance of station 4L lymph-node dissection (LND).

Methods: We retrospectively enrolled 405 patients with station 4L LND, and divided them into the positive station 4L metastasis group and the negative station 4L metastasis group. Read More

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http://dx.doi.org/10.1007/s00432-019-02880-9DOI Listing
March 2019
1 Read

Prognostic relevance of programmed cell death-ligand 1 expression and CD8+ TILs in rectal cancer patients before and after neoadjuvant chemoradiotherapy.

J Cancer Res Clin Oncol 2019 Apr 14;145(4):1043-1053. Epub 2019 Mar 14.

Cancer Center, China Medical University Hospital, China Medical University, 9F, Rehab Building, No.2 Rude Rd., Taichung, 40402, Taiwan.

Purpose/background: Radiotherapy has been recently reported to boost the therapeutic response of immune checkpoint blockade (ICB); however, few studies have focused on programmed cell death-ligand 1 (PD-L1) expression in locally advanced rectal cancer (LARC) patients who receive preoperative neoadjuvant chemoradiotherapy (neoCRT). The aim of the present study was to investigate the PD-L1 expression status and CD8+ intra-tumoral infiltrating lymphocytes (TILs) before and after neoCRT and its association with clinicopathological characteristics in rectal cancer.

Materials And Methods: Immunostainings of PD-L1 and CD8+ TILs were performed in 112 pair-matched LARC patients treated by neoCRT. Read More

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http://dx.doi.org/10.1007/s00432-019-02874-7DOI Listing
April 2019
1 Read

An overview on the methodological and reporting quality of dose-response meta-analysis on cancer prevention.

J Cancer Res Clin Oncol 2019 Mar 13. Epub 2019 Mar 13.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.

Background: Dose-response meta-analysis (DRMA) has been widely used in exploring cancer risk factors. Understanding the quality of published DRMAs on cancer risk factors may be beneficial for informed prevention for cancer.

Methods: We searched eligible DRMAs from 1st January 2011 to 31st-July-2017. Read More

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http://dx.doi.org/10.1007/s00432-019-02869-4DOI Listing
March 2019
5 Reads
3.081 Impact Factor

Retraction Note to: SOX2 oncogenes amplified and operate to activate AKT signalling in gastric cancer and predict immunotherapy responsiveness.

J Cancer Res Clin Oncol 2019 Apr;145(4):1085

Hangzhou Sanatorium Health Management Center, Hangzhou, 310007, People's Republic of China.

The Editor-in-Chief is retracting this article (Tian et al 2014) due to concerns regarding peer review, authorship and originality of the article. Read More

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http://dx.doi.org/10.1007/s00432-019-02878-3DOI Listing

Meeting report of the 14th Japan-Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine.

J Cancer Res Clin Oncol 2019 Mar 11. Epub 2019 Mar 11.

Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 00380, South Korea.

Purpose: The 14th Japan-Korea joint symposium on cancer and aging research was held at an auditorium of Saga University, Japan, May 31-Jun 2, 2018. Participants presented 31 oral and 21 poster presentations, two lectures at a luncheon seminar, plus special lectures from two Korean Emeritus Professors and founders of our joint symposia. The essential parts of the lectures are reviewed here. Read More

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http://dx.doi.org/10.1007/s00432-019-02887-2DOI Listing
March 2019
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Pathologic necrosis following neoadjuvant radiotherapy or chemoradiotherapy is prognostic of poor survival in soft tissue sarcoma.

J Cancer Res Clin Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Radiation Oncology, Medical College of Wisconsin, 9200 West Wisconsin Ave, Milwaukee, WI, 53226, USA.

Purpose: Neoadjuvant radiotherapy ± chemotherapy and wide local excision is an accepted management of localized soft tissue sarcomas (STS). Necrosis is prognostic for survival in osteosarcomas, but the significance for STS is undetermined. This study aimed to determine if percent true necrosis, opposed to a combination of necrosis and fibrosis, leads to improved survival in extremity and trunk STS. Read More

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http://link.springer.com/10.1007/s00432-019-02885-4
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http://dx.doi.org/10.1007/s00432-019-02885-4DOI Listing
March 2019
5 Reads

Iron oxide-gold core-shell nano-theranostic for magnetically targeted photothermal therapy under magnetic resonance imaging guidance.

J Cancer Res Clin Oncol 2019 Mar 7. Epub 2019 Mar 7.

Finetech in Medicine Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Recent efforts in the area of photothermal therapy (PTT) follow two important aims: (i) selective targeting of plasmonic nanoparticles to the tumor and (ii) real-time guidance of PTT operation through employing multimodal imaging modalities. In the present study, we utilized a multifunctional theranostic nanoplatform constructed from iron (III) oxide-gold (FeO@Au) core-shell nanoparticles to fulfill these aims. The Au shell exhibits surface plasmon resonance, a property that is exploited to realize PTT. Read More

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http://dx.doi.org/10.1007/s00432-019-02870-xDOI Listing
March 2019
2 Reads

Reduced vs. standard dose native E. coli-asparaginase therapy in childhood acute lymphoblastic leukemia: long-term results of the randomized trial Moscow-Berlin 2002.

J Cancer Res Clin Oncol 2019 Apr 6;145(4):1001-1012. Epub 2019 Mar 6.

Department of Oncology, Hematology and Radiotherapy, Pirogov Russian National Research Medical University, Moscow, Russia.

Purpose: Favorable outcomes were achieved for children with acute lymphoblastic leukemia (ALL) with the first Russian multicenter trial Moscow-Berlin (ALL-MB) 91. One major component of this regimen included a total of 18 doses of weekly intramuscular (IM) native Escherichia coli-derived asparaginase (E. coli-ASP) at 10000 U/m during three consolidation courses. Read More

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http://link.springer.com/10.1007/s00432-019-02854-x
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http://dx.doi.org/10.1007/s00432-019-02854-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435612PMC
April 2019
8 Reads

Absolute count of leukemic blasts in cerebrospinal fluid as detected by flow cytometry is a relevant prognostic factor in children with acute lymphoblastic leukemia.

J Cancer Res Clin Oncol 2019 Mar 6. Epub 2019 Mar 6.

Regional Children Hospital, 32, S. Deryabina Str., 620149, Ekaterinburg, Russian Federation.

Background: Usually, central nervous system (CNS) involvement in acute lymphoblastic leukemia (ALL) is diagnosed by cytomorphology (CM) of cerebrospinal fluid (CSF) on cytospin slides. Multicolor flow cytometry (MFC) provides the opportunity to detect low numbers of leukemia cells undetectable by CM. The present study aimed at evaluating the clinical significance of MFC for the diagnosis of CNS involvement at initial manifestation of childhood ALL. Read More

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http://dx.doi.org/10.1007/s00432-019-02886-3DOI Listing
March 2019
11 Reads

Neoadjuvant chemoradiotherapy delivered with helical tomotherapy under daily image guidance for rectal cancer patients: efficacy and safety in a large, multi-institutional series.

J Cancer Res Clin Oncol 2019 Apr 4;145(4):1075-1084. Epub 2019 Mar 4.

Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois, CHUV, 46 rue du Bugnon, 1011, Lausanne, Switzerland.

Purpose: Helical tomotherapy (HT) has been recently introduced in the neoadjuvant treatment of locally advanced rectal cancer. Aim of this study is to report the toxicity and local control rates of a large series of locally advanced rectal cancer patients treated with neoadjuvant chemotherapy and HT under daily image guidance followed by surgery.

Methods: Data from 117 locally advanced rectal cancer patients treated at two Swiss Radiotherapy departments were collected and analyzed. Read More

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http://dx.doi.org/10.1007/s00432-019-02881-8DOI Listing

Novel insights into the role of aptamers in the fight against cancer.

J Cancer Res Clin Oncol 2019 Apr 4;145(4):797-810. Epub 2019 Mar 4.

Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China.

Purpose: Aptamers are a class of single-stranded nucleic acid (DNA or RNA) oligonucleotides that are screened in vitro by a technique called systematic evolution of ligands by exponential enrichment (SELEX). They have stable three-dimensional structures that can bind to various targets with high affinity and specificity. Due to distinct properties such as easy synthesis, high stability, small size, low toxicity and immunogenicity, they have been largely studied as anticancer agents/tools. Read More

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http://link.springer.com/10.1007/s00432-019-02882-7
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http://dx.doi.org/10.1007/s00432-019-02882-7DOI Listing
April 2019
12 Reads

Disparity in age at lung cancer diagnosis between current and former smokers.

J Cancer Res Clin Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut Street, Suite 727, Philadelphia, PA, 19107, USA.

Purpose: In a previous study of smoking cessation in veterans with lung cancer, we noted as an incidental finding that current smokers were much younger than former smokers at diagnosis. To confirm and extend this observation, we analyzed the association of smoking status with age at diagnosis and survival of lung cancer patients.

Methods: The Jefferson Cancer Registry collects information on all cancer patients registered at this hospital. Read More

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http://dx.doi.org/10.1007/s00432-019-02875-6DOI Listing

Adherence to the EAU guidelines on Penile Cancer Treatment: European, multicentre, retrospective study.

J Cancer Res Clin Oncol 2019 Apr 1;145(4):921-926. Epub 2019 Mar 1.

Department of Urology, G. D'Annunzio University, Chieti, Italy.

Purpose: The European Association of Urology (EAU) guidelines for penile cancer (PC) are exclusively based on retrospective studies and have low grades of recommendation. The aim of this study was to assess the adherence to guidelines by investigating the management strategies for primary tumours and inguinal lymph nodes.

Methods: We retrospectively reviewed the clinical charts of 176 PC patients who underwent surgery in eight European centres from 2010 to 2016. Read More

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http://dx.doi.org/10.1007/s00432-019-02864-9DOI Listing
April 2019
3 Reads

Prognostic role of glycolysis for cancer outcome: evidence from 86 studies.

J Cancer Res Clin Oncol 2019 Apr 1;145(4):967-999. Epub 2019 Mar 1.

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Objective: The abnormal expression of the key enzymes in glycolytic pathways, including glucose transporter-1, glucose transporter-3, hexokinase-II, lactate dehydrogenase 5, pyruvate kinase M2, glucose-6-phosphate dehydrogenase, transketolase-like protein 1 and pyruvate dehydrogenase kinase-1 was reported to be associated with poor prognosis of various cancers. However, the association remains controversial. The objective of this study was to investigate the prognostic significance of glycolysis-related proteins. Read More

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http://dx.doi.org/10.1007/s00432-019-02847-wDOI Listing
April 2019
2 Reads

Insufficient radiofrequency ablation promotes the metastasis of residual hepatocellular carcinoma cells via upregulating flotillin proteins.

J Cancer Res Clin Oncol 2019 Apr 28;145(4):895-907. Epub 2019 Feb 28.

Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.

Purpose: Radiofrequency ablation (RFA) therapy has proven to be effective and feasible for early-stage hepatocellular carcinoma (HCC); however, rapid progression of residual tumor cells after RFA has been confirmed, but the molecular mechanisms of this phenomenon are poorly understood. This study evaluated the effect of the lipid raft proteins known as flotillins on the invasive and metastatic potential of residual HCC.

Methods: The human HCC cell line HCCLM3 was used to establish insufficient RFA models in vivo and in vitro. Read More

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http://dx.doi.org/10.1007/s00432-019-02852-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435628PMC
April 2019
2 Reads

Regorafenib in patients with recurrent high-grade astrocytoma.

J Cancer Res Clin Oncol 2019 Apr 28;145(4):1037-1042. Epub 2019 Feb 28.

Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, 45147, Essen, Germany.

Purpose: Antiangiogenic treatment approaches have failed to improve outcome in randomized trials of high-grade astrocytoma. One key mechanism of resistance to antiangiogenic treatment may concern the upregulation of alternative pro-angiogenic pathways. Regorafenib is a potent multikinase inhibitor that may alter some of those pathways. Read More

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http://dx.doi.org/10.1007/s00432-019-02868-5DOI Listing
April 2019
3 Reads

Aggregate analysis based on TCGA: TTN missense mutation correlates with favorable prognosis in lung squamous cell carcinoma.

J Cancer Res Clin Oncol 2019 Apr 27;145(4):1027-1035. Epub 2019 Feb 27.

School of Medicine, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.

Purpose: Lung cancer prevalence with its high mortality rate is a trending topic globally. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The human gene TTN encoding for TITIN protein is known as major mutation gene in many types of tumor including NSCLC. Read More

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http://link.springer.com/10.1007/s00432-019-02861-y
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http://dx.doi.org/10.1007/s00432-019-02861-yDOI Listing
April 2019
10 Reads

Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium.

J Cancer Res Clin Oncol 2019 Apr 27;145(4):1063-1073. Epub 2019 Feb 27.

Department of Gynecology, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Objective: The impact of angiogenesis on long-term survival of high-grade serous ovarian cancer (HGSOC) patients remains unclear. This study investigated whether angiogenic markers correlated with 5-year progression-free survival (PFS) in a large cohort of matched advanced HGSOC tissue samples.

Methods: Tumor samples from 124 primary HGSOC patients were retrospectively collected within the Tumor Bank Ovarian Cancer ( http://www. Read More

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http://dx.doi.org/10.1007/s00432-019-02877-4DOI Listing
April 2019
2 Reads

Co-mutation of TP53 and PIK3CA in residual disease after neoadjuvant chemotherapy is associated with poor survival in breast cancer.

J Cancer Res Clin Oncol 2019 Feb 26. Epub 2019 Feb 26.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center, Beijing Cancer Hospital and Institute, Peking University Cancer Hospital, Beijing, 100142, People's Republic of China.

Purpose: The prevalence and clinical relevance of TP53 and PIK3CA mutations in pretreatment breast cancer have been previously reported. However, little is known regarding these mutations in residual tumor tissues after neoadjuvant chemotherapy. Here, we investigated the association between TP53 and PIK3CA mutations in residual disease and survival of breast cancers. Read More

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http://dx.doi.org/10.1007/s00432-019-02873-8DOI Listing
February 2019

Lymph node ratio predictive of recurrence, distant metastasis, and survival in submandibular gland carcinoma patients.

J Cancer Res Clin Oncol 2019 Apr 26;145(4):1055-1062. Epub 2019 Feb 26.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Purpose: Submandibular gland (SMG) carcinoma has an unfavorable clinical course and a low survival rate. Specific tumor and nodal findings might help predict posttreatment recurrence and survival in SMG carcinoma patients. This study evaluated factors predictive of posttreatment recurrence and survival in SMG carcinoma patients. Read More

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http://dx.doi.org/10.1007/s00432-019-02876-5DOI Listing