27,557,130 results match your criteria Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research[Journal]

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Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, Yunnan, China.

Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0345-4DOI Listing
February 2019

Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019

Natural history of ventriculomegaly in adults: a cluster analysis.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

OBJECTIVEChronic ventriculomegaly in the absence of raised intracranial pressure (ICP) is a known entity in adult hydrocephalus practice. The natural history and indication for treatment is, however, poorly defined. A highly heterogeneous group, some adults with ventriculomegaly are asymptomatic, while others have life-threatening deteriorations. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18119DOI Listing
February 2019

Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis.

J Neurosurg Spine 2019 Feb 15:1-17. Epub 2019 Feb 15.

1Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences.

OBJECTIVEPredicting neurological recovery following traumatic spinal cord injury (TSCI) is a complex task considering the heterogeneous nature of injury and the inconsistency of individual studies. This study aims to summarize the current evidence on neurological recovery following TSCI by use of a meta-analytical approach, and to identify injury, treatment, and study variables with prognostic significance.METHODSA literature search in MEDLINE and EMBASE was performed, and studies reporting follow-up changes in American Spinal Injury Association (ASIA) Impairment Scale (AIS) or Frankel or ASIA motor score (AMS) scales were included in the meta-analysis. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18802DOI Listing
February 2019

Recurrent and persistent carpal tunnel syndrome: predicting clinical outcome of revision surgery.

J Neurosurg 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Plastic & Reconstructive Surgery, Radboud University Medical Center, Nijmegen.

OBJECTIVEThe aim of this study was to evaluate the self-reported outcome of revision surgery in patients with recurrent and persistent carpal tunnel syndrome (CTS) and to identify predictors of clinical outcome of revision surgery.METHODSA total of 114 hands in 112 patients were surgically treated for recurrent and persistent CTS in one of 10 specialized hand clinics. As part of routine care, patients were asked to complete online questionnaires regarding demographic data, comorbidities, and clinical severity measures. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182598DOI Listing
February 2019

Local tumor response and survival outcomes after combined stereotactic radiosurgery and immunotherapy in non-small cell lung cancer with brain metastases.

J Neurosurg 2019 Feb 15:1-6. Epub 2019 Feb 15.

1Department of Neurosurgery, Yale New Haven Hospital, New Haven, Connecticut.

OBJECTIVEConcurrent use of anti-PD-1 therapies with stereotactic radiosurgery (SRS) have been shown to be beneficial for survival and local lesional control in melanoma patients with brain metastases. It is not known, however, if immunotherapy (IT) confers the same outcome advantage in lung cancer patients with brain metastases treated with SRS.METHODSThe authors retrospectively reviewed 85 non-small cell lung cancer (NSCLC) patients with brain metastases who were treated with SRS between January 2006 and December 2016. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181371DOI Listing
February 2019

Development of a novel frameless skull-mounted ball-joint guide array for use in image-guided neurosurgery.

J Neurosurg 2019 Feb 15:1-10. Epub 2019 Feb 15.

OBJECTIVESuccessful convection-enhanced delivery of therapeutic agents to subcortical brain structures requires accurate cannula placement. Stereotactic guiding devices have been developed to accurately target brain nuclei. However, technologies remain limited by a lack of MRI compatibility, or by devices' size, making them suboptimal for direct gene delivery to brain parenchyma. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182169DOI Listing
February 2019

dl-3-n-butylphthalide for alleviation of neurological deficit after combined extracranial-intracranial revascularization for moyamoya disease: a propensity score-matched analysis.

J Neurosurg 2019 Feb 15:1-13. Epub 2019 Feb 15.

1Department of Neurosurgery, Peking University International Hospital.

OBJECTIVEPostoperative neurological deficits impair the overall outcome of revascularization surgery for patients with moyamoya disease (MMD). dl-3-n-butylphthalide (NBP) is approved for the treatment of ischemic stroke in China. This pilot study evaluated the effect of NBP on perioperative stroke and neurological deficits in patients with MMD. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182152DOI Listing
February 2019

Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database.

J Neurosurg 2019 Feb 15:1-12. Epub 2019 Feb 15.

1The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston McGovern Medical School.

OBJECTIVEThe present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment.METHODSBased on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182247DOI Listing
February 2019

Somatotopic organization of the human spinothalamic tract: in vivo computed tomography-guided mapping in awake patients undergoing cordotomy.

J Neurosurg Spine 2019 Feb 15:1-7. Epub 2019 Feb 15.

3Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

OBJECTIVEThe location of the human spinothalamic tract (STT) in the anterolateral spinal cord has been known for more than a century. The exact nature of the neuronal fiber lamination within the STT, however, remains controversial. After correlating in vivo macrostimulation-induced pain/temperature sensation during percutaneous cervical cordotomy with simultaneous CT imaging of the electrode tip location, the authors present a modern description of the somatotopy of the human cervical STT. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18172DOI Listing
February 2019

Impact of decompression surgery without fusion for lumbar spinal stenosis on sagittal spinopelvic alignment: minimum 2-year follow-up.

J Neurosurg Spine 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Department of Orthopaedic Surgery, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan; and.

OBJECTIVEThe importance of global sagittal alignment is well known. Patients with lumbar spinal stenosis (LSS) generally tend to bend forward to relieve their neurological symptoms, i.e. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE181092DOI Listing
February 2019

Outcomes in different age groups with primary Ewing sarcoma of the spine: a systematic review of the literature.

J Neurosurg Spine 2019 Feb 15:1-10. Epub 2019 Feb 15.

4Division of Neurosurgery, University of Arizona, Tucson; and.

OBJECTIVEEwing sarcoma (ES) is among the most prevalent of bone sarcomas in young people. Less often, it presents as a primary lesion of the spine (5%-15% of patients with ES).METHODSA systematic literature search was performed, querying several scientific databases per PRISMA guidelines. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18795DOI Listing
February 2019

Letter to the Editor. Reducing EVD-related infections.

J Neurosurg 2019 Feb 15:1-2. Epub 2019 Feb 15.

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http://dx.doi.org/10.3171/2018.11.JNS183251DOI Listing
February 2019

Encore careers: a solution to the unmet need in global neurosurgical care.

J Neurosurg 2019 Feb 15:1-3. Epub 2019 Feb 15.

3George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.3171/2018.11.JNS183298DOI Listing
February 2019

Correlation between fractional anisotropy changes in the targeted ventral intermediate nucleus and clinical outcome after transcranial MR-guided focused ultrasound thalamotomy for essential tremor: results of a pilot study.

J Neurosurg 2019 Feb 15:1-6. Epub 2019 Feb 15.

1Faculty of Advanced Techno-Surgery and.

OBJECTIVEThis study evaluated changes of fractional anisotropy (FA) in the ventral intermediate nucleus (VIM) of the thalamus after transcranial MR-guided focused ultrasound (TcMRgFUS) thalamotomy and their associations with clinical outcome.METHODSClinical and radiological data of 12 patients with medically refractory essential tremor (mean age 76.5 years) who underwent TcMRgFUS thalamotomy with VIM targeting were analyzed retrospectively. Read More

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http://dx.doi.org/10.3171/2018.10.JNS18993DOI Listing
February 2019

Detailed standardized protocol to prevent cerebrospinal fluid shunt infection.

J Neurosurg 2019 Feb 15:1-5. Epub 2019 Feb 15.

OBJECTIVEWhile cerebrospinal fluid (CSF) shunt surgery plays an essential role in the treatment of hydrocephalus, postoperative infection due to the implantation of foreign materials is still one of the most common and potentially serious complications of this procedure. Because no previously reported protocol has been proven to prevent postoperative infection after CSF shunt surgeries in adults, the authors investigated the effectiveness of a protocol introduced in their institution.METHODSA detailed standardized surgical protocol to prevent infection in patients undergoing CSF shunt surgeries was introduced in the authors' institution in December 2011. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181432DOI Listing
February 2019
1 Read

Outcomes of decompressive surgery for cavernous sinus meningiomas: long-term follow-up in 50 patients.

J Neurosurg 2019 Feb 15:1-8. Epub 2019 Feb 15.

1Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; and.

OBJECTIVECavernous sinus meningiomas are complex tumors that offer a perpetual challenge to skull base surgeons. The senior author has employed a management strategy for these lesions aimed at maximizing tumor control while minimizing neurological morbidity. This approach emphasizes combining "safe" tumor resection and direct decompression of the roof and lateral wall of the cavernous sinus as well as the optic nerve. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181480DOI Listing
February 2019

Correlation of perioperative risk scores with hospital costs in neurosurgical patients.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

2Department of Neurosurgery, University of Florida, Gainesville, Florida.

OBJECTIVEThe American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) online surgical risk calculator uses inherent patient characteristics to provide predictive risk scores for adverse postoperative events. The purpose of this study was to determine if predicted perioperative risk scores correlate with actual hospital costs.METHODSA single-center retrospective review of 1005 neurosurgical patients treated between September 1, 2011, and December 31, 2014, was performed. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182041DOI Listing
February 2019

Clinical characteristics of and treatment protocol for trapped temporal horn following resection of lateral ventricular trigone meningioma: a single-center experience.

J Neurosurg 2019 Feb 15:1-10. Epub 2019 Feb 15.

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing; and.

OBJECTIVETrapped temporal horn (TTH) is a rare subtype of loculated hydrocephalus that is often managed surgically. The natural history of TTH is not well understood, and there are few data on the outcomes of conservative management of this condition. The aim of this study was to analyze the clinical features and outcomes of conservatively and surgically managed cases of TTH. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182710DOI Listing
February 2019

Letter to the Editor. The career of an academic neurosurgeon: back to the future.

J Neurosurg 2019 Feb 15:1-2. Epub 2019 Feb 15.

3Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.3171/2018.11.JNS183259DOI Listing
February 2019

Spondylodiscitis in end-stage renal disease: a systematic review.

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Neurological Surgery, University of Miami, Miami, Florida; and.

OBJECTIVEDiscitis and osteomyelitis are seen in end-stage renal disease (ESRD) patients due to repeated vascular access for hemodialysis and urinary tract infections leading to recurrent bacteremia. Discitis and osteomyelitis are underdiagnosed due to the nonspecific initial presentation of back pain. In this article, we review the literature for better understanding of the problem and the importance of early diagnosis by primary care physicians and nephrologists. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18824DOI Listing
February 2019

Locating the foramen ovale by using molar and inter-eminence planes: a guide for percutaneous trigeminal neuralgia procedures.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

Departments of1Natural Sciences and Mathematics and.

OBJECTIVEThe first attempt to cannulate the foramen ovale is oftentimes unsuccessful and requires subsequent reattempts, thereby increasing the risk of an adverse event and radiation exposure to the patient and surgeon. Failure in cannulation may be attributable to variation in soft-tissue-based landmarks used for needle guidance. Also, the incongruity between guiding marks on the face and bony landmarks visible on fluoroscopic images may also complicate cannulation. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182276DOI Listing
February 2019

Rear Admiral (Astronaut) Alan Shepard: Ménière's disease and the race to the moon.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

6Department of Neurosurgery, University of South Alabama, Mobile, Alabama.

On May 5, 1961, Alan B. Shepard Jr. piloted the Freedom 7 craft into a suborbital flight to become the first American man in space. Read More

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http://dx.doi.org/10.3171/2018.9.JNS182522DOI Listing
February 2019

Leptomeningeal dissemination: a sinister pattern of medulloblastoma growth.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

3Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, Quebec, Canada.

Leptomeningeal dissemination (LMD) is the defining pattern of metastasis for medulloblastoma. Although LMD is responsible for virtually 100% of medulloblastoma deaths, it remains the least well-understood part of medulloblastoma pathogenesis. The fact that medulloblastomas rarely metastasize outside the CNS but rather spread almost exclusively to the spinal and intracranial leptomeninges has fostered the long-held belief that medulloblastoma cells spread directly through the CSF, not the bloodstream. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18506DOI Listing
February 2019

Unlikely association between Kawasaki disease and intracranial aneurysms: a prospective cohort study.

J Neurosurg Pediatr 2019 Feb 15:1-4. Epub 2019 Feb 15.

1Department of Neurosurgery, Division of Clinical Neurosciences.

OBJECTIVEKawasaki disease (KD) is a vasculitis that can cause aneurysm formation in coronary arteries and, more rarely, in peripheral arteries. A possible connection between KD and intracranial aneurysms is unclear. The purpose of this study was to determine if KD is associated with intracranial aneurysms. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18575DOI Listing
February 2019

Pontine tumor in a neonate: case report and analysis of the current literature.

J Neurosurg Pediatr 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Pediatric Hematology and Oncology, Goethe University; Departments of.

Tumors of the central nervous system represent the largest group of solid tumors found in pediatric patients. Pilocytic astrocytoma is the most common pediatric glioma, mostly located in the posterior fossa. The majority of brainstem tumors, however, are classified as highly aggressive diffuse intrinsic pontine gliomas (DIPGs) and their prognosis is dismal. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18215DOI Listing
February 2019

Adverse events and their risk factors 90 days after cervical spine surgery: analysis from the Michigan Spine Surgery Improvement Collaborative.

J Neurosurg Spine 2019 Feb 15:1-13. Epub 2019 Feb 15.

Departments of1Neurosurgery.

OBJECTIVEThe Michigan Spine Surgery Improvement Collaborative (MSSIC) is a statewide, multicenter quality improvement initiative. Using MSSIC data, the authors sought to identify 90-day adverse events and their associated risk factors (RFs) after cervical spine surgery.METHODSA total of 8236 cervical spine surgery cases were analyzed. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18666DOI Listing
February 2019

The occipitoatlantal capsular ligaments are the primary stabilizers of the occipitoatlantal joint in the craniocervical junction: a finite element analysis.

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

2Department of Neurosurgery, Division of Pediatric Neurosurgery, University of Utah, Primary Children's Hospital, Salt Lake City, Utah.

OBJECTIVEThere is contradictory evidence regarding the relative contribution of the key stabilizing ligaments of the occipitoatlantal (OA) joint. Cadaveric studies are limited by the nature and the number of injury scenarios that can be tested to identify OA stabilizing ligaments. Finite element (FE) analysis can overcome these limitations and provide valuable data in this area. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE181102DOI Listing
February 2019

Reinfection rates following adherence to Infectious Diseases Society of America guideline recommendations in first cerebrospinal fluid shunt infection treatment.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

Departments of1Pediatrics and.

OBJECTIVECSF shunt infection treatment requires both surgical and antibiotic decisions. Using the Hydrocephalus Clinical Research Network (HCRN) Registry and 2004 Infectious Diseases Society of America (IDSA) guidelines that were not proactively distributed to HCRN providers, the authors previously found high adherence to surgical recommendations but poor adherence to intravenous (IV) antibiotic duration recommendations. In general, IV antibiotic duration was longer than recommended. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18373DOI Listing
February 2019

Validation of a methodology for neuro-urological and lumbosacral stimulation studies in domestic pigs: a humanlike animal model.

J Neurosurg Spine 2019 Feb 15:1-11. Epub 2019 Feb 15.

7Neurosurgery, Pellegrin Hospital, Bordeaux, Nouvelle Aquitaine; and.

OBJECTIVESpinal cord injuries (SCIs) result in loss of movement and sensory feedback, but also organ dysfunction. Nearly all patients with complete SCI lose bladder control and are prone to kidney failure if intermittent catheterization is not performed. Electrical stimulation of sacral spinal roots was initially considered to be a promising approach for restoring continence and micturition control, but many patients are discouraged by the need for surgical deafferentation as it could lead to a loss of sensory functions and reflexes. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18676DOI Listing
February 2019

Functional characterization of two variants in the 3'-untranslated region (UTR) of transcription factor 4 gene and their association with schizophrenia in sib-pairs from multiplex families.

Asian J Psychiatr 2019 Feb 8;40:76-81. Epub 2019 Feb 8.

Department of Mechatronics and Biomedical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Cheras 43000 Kajang, Malaysia. Electronic address:

Transcription factor 4 (TCF4) gene plays an important role in nervous system development and it always associated with the risk of schizophrenia. Since miRNAs regulate targetgenes by binding to 3'UTRs of target mRNAs, the functional variants located in 3'UTR of TCF4 are highly suggested to affect the gene expressions in schizophrenia. To test the hypothesis regarding the effects of the variants located in 3'UTR of TCF4, we conducted an in silico analysis to identify the functional variants and their predicted functions. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.001DOI Listing
February 2019

Accelerated transcranial magnetic stimulation for the treatment of Patients with depression: A review.

Authors:
Fady Rachid

Asian J Psychiatr 2019 Feb 8;40:71-75. Epub 2019 Feb 8.

Private Practice, 7, place de la Fusterie, 1204, Geneva, Switzerland. Electronic address:

Major depressive disorder is a highly prevalent and profoundly disabling psychiatric disorder with significant morbidity and mortality and it is very often resistant to antidepressants, electroconvulsive therapy and psychotherapy. Therapeutic alternatives include repetitive transcranial magnetic stimulation which may be an effective choice for treatment-resistant depression but requires prolonged treatments for at least four to six weeks. Shorter exposure to this technique might be more advantageous for certain cases. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.003DOI Listing
February 2019

Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure.

Psychiatry Res Neuroimaging 2018 Dec 24;285:51-57. Epub 2018 Dec 24.

Melbourne Neuropsychiatry Center, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

Prior research indicates that socioeconomic disadvantage is associated with prefrontal cortical (PFC) development in childhood and adolescence, however the mechanisms of this link are unclear. This study investigated whether DNA methylation of the brain-derived neurotrophic factor (BDNF, which plays a key role in synaptic plasticity), mediated the association between neighborhood disadvantage and thickness of the PFC in adolescents. Neighborhood disadvantage was measured in 33 adolescents aged 12-13 years using the Socio-Economic Indexes for Areas. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2018.12.012DOI Listing
December 2018

Perceptions of the possible impact of dyslexia on nursing and midwifery students and of the coping strategies they develop and/or use to help them cope in clinical practice.

Authors:
Anna T Crouch

Nurse Educ Pract 2019 Jan 4;35:90-97. Epub 2019 Jan 4.

The University of Northampton, Faculty of Health and Society, Waterside Campus, University Drive, Northampton, NN1 5PH, United Kingdom. Electronic address:

This qualitative grounded theory case study aimed to explore the perceptions of the impact of dyslexia on nursing and midwifery students and of the coping strategies they develop and/or use to help them cope in practice. The questions addressed were: 1. What is the perceived impact of dyslexia on the nursing and midwifery student in clinical practice? 2. Read More

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http://dx.doi.org/10.1016/j.nepr.2018.12.008DOI Listing
January 2019

Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.

Redox Biol 2019 Jan 29;22:101128. Epub 2019 Jan 29.

Programa de Fisiopatología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Av. Salvador 486, Providencia 7500922, Santiago, Chile; International Center for Andean Studies (INCAS), Universidad de Chile, Baquedano s/n, Putre, Chile. Electronic address:

Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species (ROS) and/or decreased antioxidant capacity. Melatonin has antioxidant properties that decrease oxidative stress and improves pulmonary vascular function when administered postnatally. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101128DOI Listing
January 2019

Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation.

Redox Biol 2019 Feb 6;22:101137. Epub 2019 Feb 6.

Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, United States. Electronic address:

Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced neointima hyperplasia and the underlying mechanism using an inducible SMC-MAPK14 knockout mouse line (iSMC-MAPK14). Read More

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http://dx.doi.org/10.1016/j.redox.2019.101137DOI Listing
February 2019

Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved.

Environ Pollut 2019 Feb 6;248:66-73. Epub 2019 Feb 6.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China. Electronic address:

Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.015DOI Listing
February 2019

Using the entrapped bioprocess as the pretreatment method for the drinking water treatment receiving eutrophic source water.

Environ Pollut 2019 Feb 4;248:57-65. Epub 2019 Feb 4.

Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, 10617, Taiwan. Electronic address:

Control of organic matter, nutrients and disinfection byproduct formation is a major challenge for the drinking water treatment plants on Matsu Islands, Taiwan, receiving source water from the eutrophic reservoirs. A pilot entrapped biomass reactor (EBR) system was installed as the pretreatment process to reduce organic and nitrogen contents into the drinking water treatment plant. The effects of hydraulic retention time (HRT) and combination of preceding physical treatment (ultraviolet and ultrasound) on the treatment performance were further evaluated. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.128DOI Listing
February 2019

pH-dependent sorption of sulfonamide antibiotics onto biochars: Sorption mechanisms and modeling.

Environ Pollut 2019 Feb 4;248:48-56. Epub 2019 Feb 4.

Department of Environmental Science, Zhejiang University, Hangzhou, 310058, China; Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, Hangzhou, 310058, China. Electronic address:

It remains a challenge to precisely predict and control environmental behaviors of ionizable organic contaminants (IOCs) due to their species change relative to pH and because of the lack of appropriate models to illustrate the underlying pH-dependent mechanisms. We studied the pH-dependent sorption behavior of five sulfonamide antibiotics (SAs) as typical IOCs with different pK values towards a series of biochars as representative sorbents with well-characterized surface structures. After subtracting the contribution of the speciation effect using a classical speciation model, up to three unexpected enhanced sorption peaks could be found and regulated by the pK of the SAs and the pK of the biochars. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.087DOI Listing
February 2019

Composition of dissolved organic matter controls interactions with La and Al ions: Implications for phosphorus immobilization in eutrophic lakes.

Environ Pollut 2019 Feb 5;248:36-47. Epub 2019 Feb 5.

Nanjing Institute of Geography and Limnology, State Key Laboratory of Lake Science and Environment, Chinese Academy of Sciences, Nanjing, 210008, China.

Applications of aluminium (Al) salt or lanthanum (La) modified bentonite (LMB) have become popular methodologies for immobilizing phosphorus (P) in eutrophic lakes. The presence of humic substances, has been shown to inhibit this form of treatment due to the complexation with La/Al. However, the effects of other dissolved organic matter (DOM), especially that derived from phytoplankton (the dominant source in eutrophic lakes) are unknown. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.002DOI Listing
February 2019

Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort.

Environ Pollut 2019 Feb 7;248:28-35. Epub 2019 Feb 7.

Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL, USA. Electronic address:

Background: Heavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.129DOI Listing
February 2019

Validation of source detective system of the radionuclides measured in the atmosphere using a field tracer experiment.

Environ Pollut 2019 Feb 7;248:10-17. Epub 2019 Feb 7.

Environmental Safety Research Division, Korea Atomic Energy Research Institute, Daedeok-daero 989-111, Yuseong-gu, Daejeon, 305-353, Republic of Korea.

A source detective system has been developed to estimate unknown source regions and release rates of radionuclides released into the air from covert nuclear activities and accidents. This system is composed of trajectory, atmospheric dispersion, and source term estimation models. Simulated results were compared with the measurements of a field tracer experiment performed at the Yeonggwang nuclear power plant in Korea in May 1996. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.121DOI Listing
February 2019

The influence of temperature on the effects induced by Triclosan and Diclofenac in mussels.

Sci Total Environ 2019 Jan 16;663:992-999. Epub 2019 Jan 16.

Instituto de Ciencias del Mar ICM-CSIC, E-08003 Barcelona, Spain.

Little is known about the consequences of exposure to pharmaceuticals and personal care products (PPCPs) in elevated temperatures associated with climate change. To increase the knowledge on this topic, Mytilus galloprovincialis mussels were exposed to 1.0μg/L of either the antimicrobial Triclosan (TCS) or the anti-inflammatory drug Diclofenac (DIC), at control (17°C) and 4°C raised (21°C) temperatures for 28days. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.189DOI Listing
January 2019

The value of delta neutrophil index in neonatal sepsis diagnosis, follow-up and mortality prediction.

Early Hum Dev 2019 Feb 13;131:6-9. Epub 2019 Feb 13.

Division of Neonatology, Department of Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, 06010, Ankara, Turkey; Division of Neonatology, Department of Pediatrics, Yildirim Beyazit University, 06800, Ankara, Turkey.

Background: The complete blood cell count (CBC) and peripheral blood smear were the most commonly ordered tests for the diagnosis of neonatal sepsis. Delta neutrophil index (DNI) shows leucocyte differentiation and calculated while CBC is performed.

Aims: We aimed to evaluate the value of DNI in neonatal sepsis. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.02.003DOI Listing
February 2019

Patent ductus arteriosus and small for gestational age infants: Treatment approaches and outcomes.

Early Hum Dev 2019 Feb 13;131:10-14. Epub 2019 Feb 13.

Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: The current treatment approach in patent ductus arteriosus suggests the identification of high-risk infants that may benefit the most from treatment. Small for gestational age infants are a high-risk population in which the treatment approach to the patent ductus arteriosus and outcomes have not been described.

Aim: To compare the patent ductus arteriosus treatment approach and outcomes in small for gestational age and appropriate for gestational age infants. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.02.002DOI Listing
February 2019

Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways.

Int Immunopharmacol 2019 Feb 13;69:321-327. Epub 2019 Feb 13.

Dadbin Health Clinic, Kerman University of Medical Sciences, Kerman, Iran.

The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peripheral blood mononuclear cells (PBMCs) were isolated. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.008DOI Listing
February 2019
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