6,445 results match your criteria Journal of biomedical materials research. Part A[Journal]


Fluorescent Functionalized Graphene Oxide for Selective Labeling of Tumor Cells.

J Biomed Mater Res A 2019 Apr 16. Epub 2019 Apr 16.

School of Materials Science and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, India.

Fluorescence probe has attracted significant attention for biomedical imaging in recent years due to their high resolution at the cellular level. Organic based fluorescent probes with high quantum yield are widely applied in bioimaging but most of them suffer from a serious obstacle called aggregation-caused quenching in cellular systems. New fluorophore has been designed through functionalization of graphene oxide which emphatically exhibits aggregation-induced emission along with pH-responsive nanoprobe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36693DOI Listing

Evaluation of in vitro cytotoxicity and properties of polydimethylsiloxane-based polyurethane/crystalline nanocellulose bio-nanocomposites.

J Biomed Mater Res A 2019 Apr 14. Epub 2019 Apr 14.

Department of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.

Polydimethylsiloxane-based polyurethane (PU)/crystalline nanocellulose (CNC) bio-nanocomposites were produced via in-situ pre-polymer approach. Also, Hexamethylene diisocyanate (HDI) as aliphatic diisocyanate monomer and 1,4-butanediol (BDO) as aliphatic chain extender were used. CNC was incorporated into PU matrix to prepare different PU/CNC bio-nanocomposites. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.36696
Publisher Site
http://dx.doi.org/10.1002/jbm.a.36696DOI Listing
April 2019
1 Read

Modification of human MSC surface with oligopeptide-PEG-lipids for selective binding to activated endothelium.

J Biomed Mater Res A 2019 Apr 14. Epub 2019 Apr 14.

Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

Promising cell therapies using mesenchymal stem cells (MSCs) is proposed for stroke patients. Therefore, we aimed to efficiently accumulate human MSC (hMSC) to damaged brain area to improve the therapeutic effect using poly(ethylene glycol) (PEG)-conjugated phospholipid (PEG-lipid) carrying an oligopeptide as a ligand, specific for E-selectin which is up-regulated on activated endothelial cells under hypoxia like stroke. Here we synthesized E-selectin-binding oligopeptide (ES-bp) conjugated with PEG spacer having different molecular weights from 1 kDa to 40 kDa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36697DOI Listing

Biocompatibility and immunogenic response to recombinant honeybee silk material.

J Biomed Mater Res A 2019 Apr 14. Epub 2019 Apr 14.

CSIRO, Black Mountain, GPO Box 1700 , Acton, ACT, 2601, Australia.

If tolerated in biological environments, recombinant structural proteins offer the advantage that biological cues dictating cell attachment and material degradation can be modified as required for clinical application using genetic engineering. In this study, we investigate the biological response to materials generated from the recombinant honeybee silk protein, AmelF3, a structural protein that can be produced at high levels by fermentation in E. coli. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36695DOI Listing

Enhanced Adhesion of Plasma-Sprayed Commercially Pure Titanium Porous Coatings to Polished Mg-PSZ Ceramic Substrates.

J Biomed Mater Res A 2019 Apr 14. Epub 2019 Apr 14.

Missouri Bone & Joint Research Foundation, St. Louis, MO.

The purpose of this study was to evaluate the suitability of a plasma sprayed titanium porous coating on polished magnesia-stabilized zirconia (Mg-PSZ) ceramic surfaces. We hypothesized that diffusion bonding was responsible for the adhesion of the coating to the ceramic substrate. Mg-PSZ tensile test coupons were vibratory polished (roughness Sa = 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36694DOI Listing
April 2019
1 Read

Human Umbilical Cord-derived Scaffolds for Cartilage Tissue Engineering.

J Biomed Mater Res A 2019 Apr 15. Epub 2019 Apr 15.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, 1665659911, ACECR, Tehran, Iran.

Since articular cartilage is an avascular tissue, it has limited self-regeneration capacity after damage. Current methods for human bone marrow-derived Mesenchymal Stem Cell (hBM-MSC) differentiation into cartilage result in tissues with a lower quality as compared to native articular cartilage. Decellularized biological scaffolds have the potential to provide appropriate signals, in order to support cellular retention, migration, proliferation and differentiation. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.36698
Publisher Site
http://dx.doi.org/10.1002/jbm.a.36698DOI Listing
April 2019
1 Read

Safety and Biocompatibility of Injectable Vaccine Adjuvants Composed of Thermogelling Block Copolymer Gels.

J Biomed Mater Res A 2019 Apr 10. Epub 2019 Apr 10.

Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.

Injectable thermogelling polymers have been recently investigated as novel adjuvants and delivery systems for next generation vaccines. As research into natural and synthetic biocompatible polymers progresses, the safety and biocompatibility of these compounds is of paramount importance. We have developed cationic pentablock copolymer vaccine adjuvants based on Pluronic F127, a thermogelling triblock copolymer that has been approved by the FDA for multiple applications, and methacrylated poly(diethylaminoethyl methacrylate) (PDEAEM) outer blocks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36691DOI Listing

Decellularized Human Liver Scaffold-Based Three-dimensional Culture System Facilitate HBV Infection.

J Biomed Mater Res A 2019 Apr 8. Epub 2019 Apr 8.

The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, ChongQing, China.

Hepatitis B virus (HBV) study is hampered by lacking of idea cell model which support effective HBV infection, and meanwhile recapitulate hepatocyte biology function in vivo. In this study, we developed decellularized human liver scaffolds for cell culture and further applied for HBV infection. As a result, primary human hepatocytes (PHH) engrafted into liver scaffolds and maintained differentiation with stable albumin secretion and liver specific gene expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36690DOI Listing

Injectable Schiff base polysaccharide hydrogels for intraocular drug loading and release.

J Biomed Mater Res A 2019 Apr 4. Epub 2019 Apr 4.

Material Science and Engineering College, Qingdao University, Qingdao, Shandong, 266071, People's Republic of China.

A novel voriconazole (VCZ)-loaded injectable hydrogel was in situ synthetized via a Schiff base reaction between polyaldehyde dextran (PAD) and carboxymethyl chitosan (CMCTS) for intraocular drug loading and release. Water-insoluble VCZ, which is an effective agent in clinic treating fungal endophthalmitis, was loaded through the inclusion into the β-cyclodextrin (β-CD) cavity based on host-guest interaction on the linear poly β-CD chain, which was in situ twined in the cross-linked hydrogel structure. The gelation time, degradation, and drug release process were investigated by studying three kinds of hydrogels with different volume ratio of PAD to CMCTS resolving in phosphate buffered saline (PBS) solution (3:7, 6:7, 9:7), respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36677DOI Listing
April 2019
1 Read

Producing hybrid nanofiber-based on /PAN/Fe3O4/ Zeolite/Nettle plant extract/Urease and a deformed coaxial natural polymer to reduce toxicity materials in the blood of dialysis patients.

J Biomed Mater Res A 2019 Apr 3. Epub 2019 Apr 3.

Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, P.O. Box 1651153311, Tehran, Iran.

On incidence of kidney failure, the concentration of urea increases and there is need for patients to visit the hospital all through the week for blood purification. However, current hemodialysis has been found to reduce only 66-75% urea in the blood of patients. The main goal of this article is to observe the effect of biocompatible and high mechanical hemodiafiltration in reducing urea and creatinine within the shortest time frame, using two methods of Nano electrospinning fiber (hybrid and coaxial). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36689DOI Listing
April 2019
1 Read

Progress in Developing Decellularized Bioscaffolds for Enhancing Skin Construction.

J Biomed Mater Res A 2019 Apr 3. Epub 2019 Apr 3.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

The skin is the largest organ in the human body, and skin defects are very common. Skin flap transplantation is the best treatment for serious wound defects, and donor site tissues are always sacrificed during this process. Decellularized biomaterials, derived mainly from various nonautologous organs and tissues, have promising applications in tissue engineering and repair of wound defects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36688DOI Listing
April 2019
5 Reads

Elucidating the Role of Size of Hydroxyl Apatite Particles towards the Development of Competent Antiosteoporotic Bioceramic Materials: In Vitro and In Vivo Studies.

J Biomed Mater Res A 2019 Mar 29. Epub 2019 Mar 29.

Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Osteoporosis caused by overdose of steroids is one of the major concerns for the orthopedic surgeons. Current therapeutic strategies offer limited success due to their inability to regenerate damaged bone at osteoporosis site. Therefore, there is an urgent need to develop a material having bone regeneration ability and also, ability to cure osteoporosis simultaneously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36687DOI Listing
March 2019
1 Read

IR820-loaded PLGA nanoparticles for photothermal therapy of triple-negative breast cancer.

J Biomed Mater Res A 2019 Mar 28. Epub 2019 Mar 28.

Department of Biomedical Engineering, University of Delaware, 161 Colburn Lab, Newark, Delaware, 19716.

Triple-negative breast cancer (TNBC) accounts for 15-25% of breast cancer cases and lacks expression of the three most common receptors seen on other subtypes of breast cancer. This lack of expression makes TNBC unsusceptible to currently available targeted or hormonal therapies, so new treatment strategies are desperately needed. Photothermal therapy (PTT), which utilizes nanoparticles (NPs) embedded in tumors as exogenous energy absorbers to convert externally applied near-infrared (NIR) light into heat to ablate cancer cells, has shown promise as an alternative strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36685DOI Listing
March 2019
3 Reads

Carboxymethyl kappa Carrageenan-modified decellularized small-diameter vascular grafts improving thromboresistance properties.

J Biomed Mater Res A 2019 Mar 28. Epub 2019 Mar 28.

Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

The development of decellularized small diameter vascular grafts is a potential solution for patients requiring vascular reconstructive procedures. However, there is a limitation for acellular scaffolds due to incomplete recellularization and exposure of extracellular matrix (ECM) components to whole blood resulting in platelet adhesion. To address this issue, a perfusion decellularization method was developed using a custom-designed set up which completely removed cell nuclei and preserved three dimensional structure and mechanical properties of native tissue (sheep carotid arteries). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36684DOI Listing

Preparation and properties of dopamine-modified alginate/chitosan-hydroxyapatite scaffolds with gradient structure for bone tissue engineering.

J Biomed Mater Res A 2019 Mar 28. Epub 2019 Mar 28.

The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Chong'an District, Jiangsu, China.

Three-dimensional (3D) homogenous scaffolds composed of natural biopolymers have been reported as superior candidates for bone tissue engineering. There are still remaining challenges in fabricating the functional scaffolds with gradient structures to similar with natural bone tissues, as well as high mechanical properties and excellent affinity to surround tissues. Herein, inspired by the natural bone structure, a gradient-structural scaffold composed of functional biopolymers was designed to provide an optimized 3D environment for promoting cell growth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36678DOI Listing

Multimodal porogen platforms for calcium phosphate cement degradation.

J Biomed Mater Res A 2019 Mar 28. Epub 2019 Mar 28.

Department of Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.

Calcium phosphate cements (CPCs) represent excellent bone substitute materials due to their biocompatibility and injectability. However, their poor degradability and lack of macroporosity limits bone regeneration. The addition of poly(d,l-lactic-co-glycolic acid) (PLGA) particles improves macroporosity and therefore late stage material degradation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36686DOI Listing

In vivo systemic toxicity assessment of an oxidized dextrin-based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes.

J Biomed Mater Res A 2019 Mar 28. Epub 2019 Mar 28.

CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.

The worldwide incidence of bone disorders is raising, mainly due to aging population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic-based SBSs commercially available display limited handling properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36683DOI Listing

A novel braided biodegradable stent for use in congenital heart disease: Short-term results in porcine iliac artery.

J Biomed Mater Res A 2019 Mar 27. Epub 2019 Mar 27.

Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

To evaluate the properties and efficacy of a novel braided biodegradable stent (BBS) consisting of poly (p-dioxanone) (PPDO) and polycaprolactone (PCL) for usage in children with congenital cardiovascular diseases. PCL/PPDO composite filaments were fabricated by coating PCL layers onto PPDO filaments, which were fused with PPDO monofilaments to form the BBS. Physical properties of BBSs including elastic recovery rate, deformation rate, and mechanical characteristics with adjunctive post-dilation were evaluated by radial force-tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36682DOI Listing
March 2019
2 Reads

Novel ultrafine-grained β-type Ti-28Nb-2Zr-8Sn alloy for biomedical applications.

J Biomed Mater Res A 2019 Mar 27. Epub 2019 Mar 27.

Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.

Titanium alloys are widely accepted as orthopedic or dental implant materials in the medical field. It is important to evaluate the biocompatibility of an implant material prior to use. A new β-type ultrafine-grained Ti-28Nb-2Zr-8Sn (TNZS) alloy with low Young's modulus of 31. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.36679
Publisher Site
http://dx.doi.org/10.1002/jbm.a.36679DOI Listing
March 2019
2 Reads

Sulfated hyaluronan-containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles.

J Biomed Mater Res A 2019 Mar 27. Epub 2019 Mar 27.

Leipzig University, Saxon Incubator for Clinical Translation, TRR 67.

The aim of this work was to establish improved cultivation conditions for human keratinocytes (HUKORS) and melanocytes (HUMORS) from the outer root sheath (ORS) of human hair follicles for purposes of generating an epidermal graft. To this end, the cells were cultivated on artificial extracellular matrix coatings composed of collagen (COLL) and hyaluronan (HA) with varying sulfation degrees. HUKORS and HUMORS were characterized based on their morphology and proliferation, marker gene expression, protein expression and melanin content in melanocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36680DOI Listing
March 2019
2 Reads

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering.

J Biomed Mater Res A 2019 Mar 27. Epub 2019 Mar 27.

Polymer Unit, National Metal and Materials Technology Center (MTEC), NSTDA, Pathumthani, Thailand.

Calcium phosphate bioceramics nanoparticles such as nano-hydroxyapatite (nHA) and nano-tricalcium phosphate (nTCP) are the main focus of basic and applied research for bone tissue regeneration. In particular, a combination of these two phases (nHA + nTCP) which refers to as "nano-biphasic calcium phosphates (nBCP)" is of interest due to the preferred biodegradation nature compared to single-phase bioceramics. However, the available synthesis processes are challenging and the biomaterials properties are yet to be optimized to mimic the physiochemical properties of the natural nanoscale bone apatite. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36681DOI Listing

In vivo evaluation of an electrospun gelatin nonwoven mat for regeneration of epithelial tissues.

J Biomed Mater Res A 2019 Mar 24. Epub 2019 Mar 24.

Department of Plastic and Hand Surgery, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

One major objective in epithelial tissue engineering is to identify a suitable biomaterial that supports epithelial tissue formation. Therefore, the purpose of this study is to elucidate a novel electrospun gelatin nonwoven mat (NWM) for epithelial tissue engineering purposes in vivo. This NWM was seeded with either human gingival keratinocytes (GK, in coculture with gingival fibroblast) or human skin epithelial keratinocytes (EK, in coculture with skin dermal fibroblasts). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36676DOI Listing

3D printing collagen/chitosan scaffold ameliorated axon regeneration and neurological recovery after spinal cord injury.

J Biomed Mater Res A 2019 Mar 23. Epub 2019 Mar 23.

Tianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, Logistics University of PAPF, Tianjin 300162, China.

Spinal cord injury (SCI) is a disaster that can cause severe motor, sensory, and functional disorders. Implanting biomaterials have been regarded as hopeful strategies to restore neurological function. However, no optimized scaffold has been available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36675DOI Listing
March 2019
3 Reads

Microneedles of chitosan-porous carbon nanocomposites: Stimuli (pH and electric field)-initiated drug delivery and toxicological studies.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

Department of Applied Physics, Defence Institute of Advanced Technology, Pune, Maharashtra, 411025, India.

An array of microneedles (MNs) of chitosan-graphene assembled in porous carbon (CS-GAPC) nanocomposites has been synthesized and evaluated. The safety of the formulated system has been ensured using detailed in vivo toxicological studies and efficacy has been ensured by evaluating the stimuli (pH and electric field) initiated drug delivery properties. Drug cephalexin has been incorporated in these MNs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36672DOI Listing

Differential inflammatory landscape stimulus during titanium surfaces obtained osteogenic phenotype.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

Department of Chemistry and Biochemistry, Bioscience Institute, State University of São Paulo - UNESP, campus Botucatu, Botucatu, São Paulo, Brazil.

Molecular mechanism governing inflammatory scenario in response to titanium (Ti)-nanotexturing surfaces needs to be better addressed. Thus, we subjected pre-osteoblast to different Ti-texturing surfaces, as follows: machined (Mac), double acid-etching (DAE), and nanoscaled hydroxyapatite-blasted titanium surface (nHA), considering the cells chronically responding either directly (when the cells were cultured onto the surfaces) or indirectly (when the cells were challenged with the conditioned medium by the surfaces), up to 10 days. Our results showed that there is a dynamic requirement of inflammatory-related genes activation in response to nHA by up expressing IL1ß, IL6, IL10, and IL33 (direct condition) and IL6, IL10, IL18 (indirect condition). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36673DOI Listing

Modulating cancer cell mechanics and actin cytoskeleton structure by chemical and mechanical stimulations.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

School of Biomedical Engineering, University of Technology Sydney, Sydney, Australia.

To date, a myriad of strategies has been suggested for targeting the chemical signaling of cancer cells. Also, biomechanical features are gaining much more attention. These features can be used as biomarkers which influence cancer progression. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.36670
Publisher Site
http://dx.doi.org/10.1002/jbm.a.36670DOI Listing
March 2019
3 Reads

A murine model of cutaneous aspergillosis for evaluation of biomaterials-based local delivery therapies.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

Department of Bioengineering, Rice University, Houston, Texas.

Cutaneous fungal infection is a challenging condition to treat that primarily afflicts immunocompromised patients. Local antifungal therapy may permit the delivery of high concentrations of antifungals directly to wounds while minimizing systemic toxicities. However, the field currently lacks suitable in vivo models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36671DOI Listing
March 2019
2 Reads

Photochemically crosslinked cell-laden methacrylated collagen hydrogels with high cell viability and functionality.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, Florida, 32901.

Irgacure 2959 (I2959) is widely used as a photoinitiator for photochemical crosslinking of hydrogels. However, the free radicals generated from I2959 have been reported to be highly cytotoxic. In this study, methacrylated collagen (CMA) hydrogels were photochemically crosslinked using two different photoinitiators (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36668DOI Listing

Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

Center of MicroBioRobotics @SSSA, Fondazione Istituto Italiano di Tecnologia, Pontedera (Pisa), Viale Rinaldo Piaggio 34, 56025, Italy.

Cerium oxide nanoparticles (nanoceria [NC]) have attracted much attention in biomedicine due to their surface composition that confers interesting redox activities and regenerative properties. Studies have demonstrated that the application of NPs in biomedicine can influence components of hemostatic system, inducing blood clotting, alterations of blood cells, and endothelial cell functions. NC were tested in vitro to assess their hemocompatibility and anticoagulant, anti-inflammatory, and anti-senescence activity in human endothelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36669DOI Listing
March 2019
2 Reads

Design and development of metallic biomaterials with biological and mechanical biocompatibility.

Authors:
Mitsuo Niinomi

J Biomed Mater Res A 2019 May;107(5):944-954

Institute for Materials Research, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan.

In the present article, the recent trends in the research and development of metallic biomaterials are discussed with focus on the results obtained by the author's group. The design of biocompatible metallic biomaterials possessing excellent biological and mechanical properties, including titanium alloys with low Young's modulus, is reviewed with focus on Young's modulus, fatigue strength, and peculiar behavior. The evaluation of biological compatibility including cell viability and living tissue compatibility using animal models and surface modifications using bioactive ceramic and blood-compatible polymers are summarized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36667DOI Listing
May 2019
5 Reads

Biocompatible HA@Fe O @N-CDs hybrids for detecting and absorbing lead ion.

J Biomed Mater Res A 2019 Feb 28. Epub 2019 Feb 28.

College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, China.

The trinary hydroxyapatite@Fe O @N-doped carbon dots (HA@Fe O @N-CDs) hybrids were prepared by one-pot hydrothermal approach and utilized to detect and remove lead ion from aqueous solution. The structures and morphologies of as-obtained nanorod-like HA@Fe O @N-CDs hybrids were characterized by X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy measurements. These HA@Fe O @N-CDs hybrids possess good magnetism by magnetic hysteresis test and multi-colored fluorescence by the CLSM measurement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36666DOI Listing
February 2019
1 Read

Halloysite nanotubes as tools to improve the actual challenge of fixed doses combinations in tuberculosis treatment.

J Biomed Mater Res A 2019 Feb 28. Epub 2019 Feb 28.

Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, 18071 s/n, Granada, Spain.

Halloysite nanotubes (HLNTs) were used as nanocarriers of the tuberculostatic agent isoniazid (INH), a BCS (Biopharmaceutics Classification System) class III drug. Self-assembling nanohybrids (INH-loaded HLNTs) with an average outer diameter of 90 nm and polydispersity index of 0.7 approximately, were obtained by spontaneous adsorption of INH molecules to HLNTs powder in aqueous medium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36664DOI Listing
February 2019
4 Reads

Controlled in vitro degradation behavior of highly oriented long-chain-branched poly(lactic acid) produced by solid-phase die drawing.

J Biomed Mater Res A 2019 Feb 28. Epub 2019 Feb 28.

School of Engineering, Design and Technology, University of Bradford, Bradford, United Kingdom.

Highly oriented long-chain-branched poly(lactic acid) (LCB-PLA) was fabricated through solid-phase die drawing technology, and the in vitro degradation behavior of the oriented samples in phosphate-buffered saline (PBS) was studied. During degradation, the weight retention and molecular weight for both PLA and LCB-PLA increased with the increase of draw ratio. Moreover, the degradation autocatalytic effect was delayed, and the deterioration of mechanical strength was reduced by orientation, which was beneficial for controlling the degradation degree and decay rate of strength for PLA as bone fixation materials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36665DOI Listing
February 2019
1 Read

Peptide-modified bone repair materials: Factors influencing osteogenic activity.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.

Many factors have been demonstrated as having an influencing effect on the osteogenic activity of the peptide-modified bone repair materials. However, most of studies only focus on one or two aspects that result in an incomplete direction for materials preparation, characterization, and performance evaluation. In this review, we reported several factors through summarizing previous research studies, which are mainly centered on three aspects: (1) the characteristics of peptide immobilized on the surface of matrix (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36663DOI Listing
February 2019

Hierarchical microchannel architecture in chitosan/bioactive glass scaffolds via electrophoretic deposition positive-replica.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Milan, Italy.

One of the main challenges in the design of scaffolds for cortical bone regeneration is mimicking the highly oriented, hierarchical structure of the native tissue in an efficient, simple, and consistent way. As a possible solution to this challenge, positive replica based on electrophoretic deposition (EPD) was here evaluated as a technique to produce organic/inorganic scaffolds with oriented micro-porosities mimicking Haversian canals diameter and spacing. Two different sizes of 45S5 bioactive glass (BG) powders were chosen as inclusions and loaded in a chitosan matrix via EPD on micro-patterned cathodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36660DOI Listing
February 2019
1 Read

Current state-of-the-art and future perspectives of the three main modern implant-dentistry concerns: Aesthetic requirements, mechanical properties, and peri-implantitis prevention.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

Nanomaterials and Nanotechnology Research Centre (CINN), Universidad de Oviedo (UO), Consejo Superior de Investigaciones Científicas (CSIC), Principado de Asturias (PA), Avenida de la Vega 4-6, El Entrego, Asturias, 33940, Spain.

The idea of permanent tooth replacement goes back to the year 2000 BC at least, when carved bamboo pegs were used to replace missing teeth in ancient China. The phenomenon of osseointegration, however, was not verified until the mid-1960s, when Branemark discovered that titanium could integrate to bone. Since then, the osseointegration capacity of implants has been profoundly investigated and implants as such have evolved enormously in all possible aspects, from material selection and processing to specific surface engineering, among many others. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36661DOI Listing
February 2019

Effects of hydrogen peroxide on biological characteristics and osteoinductivity of decellularized and demineralized bone matrices.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

Due to the similar collagen composition and closely physiological relationship with soft connective tissues, demineralized bone matrices (DBMs) were used to repair the injured tendon or ligament. However, the osteoinductivity of DBMs would be a huge barrier of these applications. Hydrogen peroxide (H O ) has been proved to reduce the osteoinductivity of DBMs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36662DOI Listing
February 2019
1 Read
3.369 Impact Factor

Roles of electrical stimulation in promoting osteogenic differentiation of BMSCs on conductive fibers.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, 99164.

The strategy of using conductive materials in regenerating bone defects is attractive, benefiting from the bioelectricity feature of natural bone tissues. Thereby, POP conductive fibers were fabricated by coating polypyrrole (PPY) onto electrospun poly(l-lactide) (PLLA) fibers, and their potentials in promoting osteogenic differentiation of bone mesenchymal stromal cells (BMSCs) were investigated. Different from the smooth-surfaced PLLA fibers, POP fibers were rough-surfaced and favorable for protein adsorption and mineralization nucleation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36659DOI Listing
February 2019

Use of affinity allows anti-inflammatory and anti-microbial dual release that matches suture wound resolution.

J Biomed Mater Res A 2019 Feb 16. Epub 2019 Feb 16.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.

Surgical sutures are vulnerable to bacterial infections and biofilm formation. At the suture site, pain and undesirable, excess inflammation are additionally detrimental to wound healing. The development of a polymerized cyclodextrin (pCD) coated surgical suture introduces the capability to locally deliver both anti-inflammatory and anti-microbial drugs throughout the phases of acute and chronic healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36658DOI Listing
February 2019
2 Reads

Sustained release of N-acetylcysteine by sandwich structured polycaprolactone/collagen scaffolds for wound healing.

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

PCL (poly-caprolactone) nanofibers have good biocompatibility and high porosity, which are usually utilized for application in wound dressings. However, wound healing could be hindered by the overproduction of reactive oxygen species (ROS) and different factors. Pure nanofibers cannot satisfy these requirements of wound healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36656DOI Listing
February 2019

The effect of nacre extract on cord blood-derived endothelial progenitor cells: A natural stimulus to promote angiogenesis?

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), UMR 7365, CNRS-Université de Lorraine, Vandœuvre-Lès-Nancy, F-54505, France.

Angiogenesis is a critical parameter to consider for the development of tissue-engineered bone substitutes. The challenge is to promote sufficient vascularization in the bone substitute to prevent cell death and to allow its efficient integration. The capacity of nacre extract to restore the osteogenic activity of osteoarthritis osteoblasts has already been demonstrated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36655DOI Listing
February 2019
4 Reads

Zinc-oxide nanoparticles act catalytically and synergistically with nitric oxide donors to enhance antimicrobial efficacy.

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia.

The development of infection-resistant materials is of substantial importance as seen with an increase in antibiotic resistance. In this project, the nitric oxide (NO)-releasing polymer has an added topcoat of zinc oxide nanoparticle (ZnO-NP) to improve NO-release and match the endogenous NO flux (0.5-4 × 10 mol cm min ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36657DOI Listing
February 2019
2 Reads

A novel 3D printed cage with microporous structure and in vivo fusion function.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

In this study, a novel 3D printed porous titanium cage (3D printed cage) with interconnected pores inside was designed and manufactured. Observations by scanning electron microscopy showed that the inside of the 3D printed cage had an octahedral porous structure, with the pores uniform in size and connected to each other. The mechanical properties analysis found that the Young's modulus and compressive strength of the porous structure were close to those of the bone structure, and the overall stiffness was slightly higher than that of the polyether ether ketone (PEEK) material, but was significantly lower than that of the titanium alloy solid module. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36652DOI Listing
February 2019
17 Reads

Potential core-shell designed scaffolds with a gelatin-based shell in achieving controllable release rates of proteins for tissue engineering approaches.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.

The biomaterials design as core-shell structures opens a new door to the release of susceptible biomolecules in a controllable manner and enables to place natural biomaterials as shell layers to impart the effective biofunctional features at surfaces. In this study, core-shell designed scaffolds were prepared using coaxial electrospinning with hybrid of gelatin (GT)/polycaprolactone (PCL) at different weight ratios as their shell and protein solution as their core, followed by cross-linking to impart controllable release rates, tunable mechanical properties, and enhanced cytocompatibility. SEM, FM, and TEM confirmed the successful production of uniform core-shell nanofibers and homogeneous protein distribution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36653DOI Listing
February 2019

Aligned topography mediated cell elongation reverses pathological phenotype of in vitro cultured keloid fibroblasts.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Key Laboratory of Tissue Engineering Research, National Tissue Engineering Center of China, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Topography modified cell behavior remains less explored in diseased cells. This study investigated the reversing effect on the pathological phenotype of keloid fibroblasts via culturing cells on a parallel microgrooved surface. The results showed that this particular topography with 3 μm groove depth and 10 μm width could significantly elongate and align the cultured cells with reduced cell (nucleus) area and increased cell (nucleus) body aspect ratio and cell (nucleus) body major axis (p < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36650DOI Listing
February 2019
3 Reads

Epithelial sealing effectiveness against titanium or zirconia implants surface.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

The aims of implant treatment now involve not only restoration of mastication function, but also recovery of esthetics. Currently, zirconia is widely used as an esthetic material for implant abutment. Therefore, it is very important to understand the efficacy of zirconia for epithelial sealing as an implant material. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36651DOI Listing
February 2019
2 Reads

Creation of a unique architectural structure of bioactive glass sub-micron particles incorporated in a polycaprolactone/gelatin fibrous mat; characterization, bioactivity, and cellular evaluations.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

In this study, submicron, monodispersed, spherical bioactive glass (BG) particles with a mean diameter of 720 ± 80 nm were produced through sol-gel process. The prepared BG particles were successfully incorporated into 70/30 (W/W) ratio of polycaprolactone/gelatin (PCL/GT) nanofibrous mats (250 ± 60 nm) through electrospinning to obtain a unique architectural structure for the first time. To enhance biodegradation and stability of the scaffolds, crosslinking using gluteraldehyde was applied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36649DOI Listing
February 2019
3 Reads

Macrophages significantly enhance wound healing in a vascularized skin model.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Allergology, RWTH Aachen University Hospital, Aachen, Germany.

Tissue-engineered dermo-epidermal skin grafts could be applied for the treatment of large skin wounds or used as an in vitro wound-healing model. However, there is currently no skin replacement model that includes both, endothelial cells to simulate vascularization, and macrophages to regulate wound healing and tissue regeneration. Here, we describe for the first time a tissue-engineered, fully vascularized dermo-epidermal skin graft based on a fibrin hydrogel scaffold, using exclusively human primary cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36648DOI Listing
February 2019
11 Reads

The thickness of poly-phenoxyethyl methacrylate brush interferes with cellular behavior and function of myofibers.

J Biomed Mater Res A 2019 Feb 5. Epub 2019 Feb 5.

Guangdong Provincial Key Laboratory of Medical Biomechanics, Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

Introducing or grafting molecules onto biomaterial surfaces to regulate muscle cell destination via biophysical cues is one of the important steps for biomaterial design in muscle tissue engineering. Therefore, it is important to understand the interaction between myoblasts and myofibers with substrates modified by biomimetic layer with different thicknesses. In this study, we used a surface-induced atom transfer radical polymerization method to synthetize and graft poly-phenoxyethyl methacrylate (PHEMA) brushes having different lengths on the glass substrates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36636DOI Listing
February 2019
1 Read

Engineering molecularly mobile polyrotaxane surfaces with heparin-binding EGF-like growth factors for improving hepatocyte functions.

J Biomed Mater Res A 2019 May 19;107(5):1080-1085. Epub 2019 Feb 19.

Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.

Hepatocytes in vitro may be useful for treating various types of liver diseases, but these cells immediately lose their functions. Here, we designed sulfonated-polyrotaxane (PRX) surfaces with immobilized heparin binding-epidermal growth factor-like growth factors (HB-EGFs) for improving hepatic functions. Sulfonated-PRX triblock copolymers, composed of sulfopropyl ether-modified α-cyclodextrins (α-CDs) threaded onto a poly(ethylene glycol) (PEG) chain as a PRX segment and poly(benzyl methacrylate) at both terminals of the PEG as anchoring segments, were coated onto polystyrene surfaces by a drop cast method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36646DOI Listing
May 2019
1 Read