6,406 results match your criteria Journal of biomedical materials research. Part A[Journal]


Sustained release of N-acetylcysteine by sandwich structured polycaprolactone/collagen scaffolds for wound healing.

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

PCL (poly-caprolactone) nanofibers have good biocompatibility and high porosity, which are usually utilized for application in wound dressings. However, wound healing could be hindered by the overproduction of reactive oxygen species (ROS) and different factors. Pure nanofibers cannot satisfy these requirements of wound healing. Read More

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http://dx.doi.org/10.1002/jbm.a.36656DOI Listing
February 2019

The effect of nacre extract on cord blood-derived endothelial progenitor cells: a natural stimulus to promote angiogenesis?

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), UMR 7365, Vandœuvre-Lès-Nancy, F-54505, France.

Angiogenesis is a critical parameter to consider for the development of tissue-engineered bone substitutes. The challenge is to promote sufficient vascularization in the bone substitute to prevent cell death and to allow its efficient integration. The capacity of nacre extract to restore the osteogenic activity of osteoarthritis osteoblasts has already been demonstrated. Read More

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http://dx.doi.org/10.1002/jbm.a.36655DOI Listing
February 2019
1 Read

Zinc-oxide Nanoparticles Act Catalytically and Synergistically with Nitric Oxide Donors to Enhance Antimicrobial Efficacy.

J Biomed Mater Res A 2019 Feb 8. Epub 2019 Feb 8.

School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, USA.

The development of infection resistant materials is of substantial importance as seen with an increase in antibiotic resistance. In this project, the nitric oxide (NO)-releasing polymer has an added topcoat of zinc oxide nanoparticle (ZnO-NP) to improve NO-release and match the endogenous NO flux (0.5 - 4 x 10 mol cm min ). Read More

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http://dx.doi.org/10.1002/jbm.a.36657DOI Listing
February 2019

A novel 3D printed Cage with microporous structure and in vivo fusion function.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

In this study, a novel 3D printed porous titanium Cage (3D printed Cage) with interconnected pores inside was designed and manufactured. Observations by scanning electron microscopy showed that the inside of the 3D printed Cage had an octahedral porous structure, with the pores uniform in size and connected to each other. The mechanical properties test found that the Young's modulus and compressive strength of the porous structure were close to those of the bone structure, and the overall stiffness was slightly higher than that of the PEEK material, but was significantly lower than that of the titanium alloy solid module. Read More

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http://dx.doi.org/10.1002/jbm.a.36652DOI Listing
February 2019
2 Reads

Potential core-shell designed scaffolds with a gelatin-based shell in achieving controllable release rates of proteins for tissue engineering approaches.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.

The biomaterials design as core-shell structures opens a new door to the release of susceptible biomolecules in a controllable manner and enables to place natural biomaterials as shell layers to impart the effective biofunctional features at surfaces. In this study, core-shell designed scaffolds were prepared using coaxial electrospinning with hybrid of gelatin (GT)/polycaprolactone (PCL) at different weight ratios as their shell and protein solution as their core, followed by crosslinking to impart controllable release rates, tunable mechanical properties and enhanced cytocompatibility. SEM, FM, and TEM confirmed the successful production of uniform core-shell nanofibers and homogeneous protein distribution. Read More

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http://dx.doi.org/10.1002/jbm.a.36653DOI Listing
February 2019

Aligned topography mediated cell elongation reverses pathological phenotype of in vitro cultured keloid fibroblasts.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering Research, National Tissue engineering Center of China, Shanghai, P. R. China.

Topography modified cell behavior remains less explored in diseased cells. This study investigated the reversing effect on the pathological phenotype of keloid fibroblasts via culturing cells on a parallel microgrooved surface. The results showed that this particular topography with 3 μm groove depth and 10 μm width could significantly elongate and align the cultured cells with reduced cell (nucleus) area and increased cell(nucleus) body aspect ratio and cell (nucleus) body major axis (p<0. Read More

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http://dx.doi.org/10.1002/jbm.a.36650DOI Listing
February 2019
1 Read

Epithelial sealing effectiveness against titanium or zirconia implants surface.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

The aims of implant treatment now involve not only restoration of mastication function, but also recovery of esthetics. Currently, zirconia is widely used as an esthetic material for implant abutment. Therefore, it is very important to understand the efficacy of zirconia for epithelial sealing as an implant material. Read More

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http://dx.doi.org/10.1002/jbm.a.36651DOI Listing
February 2019
2 Reads

Creation of a unique architectural structure of bioactive glass sub-micron particles incorporated in a polycaprolactone/gelatin fibrous mat; characterization, bioactivity and cellular evaluations.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

In this study, submicron, monodispersed, spherical bioactive glass (BG) particles with a mean diameter of 720 ± 80 nm were produced through sol-gel process. The prepared BG particles were successfully incorporated into 70/30 (W/W) ratio of polycaprolactone / gelatin (PCL/GT) nanofibrous mats (250 ± 60 nm) through electrospinning to obtain a unique architectural structure for the first time. To enhance biodegradation and stability of the scaffolds, crosslinking using gluteraldehyde was applied. Read More

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http://dx.doi.org/10.1002/jbm.a.36649DOI Listing
February 2019
2 Reads

Macrophages significantly enhance wound healing in a vascularized skin model.

J Biomed Mater Res A 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Allergology, RWTH Aachen University Hospital, Aachen, Germany.

Tissue-engineered dermo-epidermal skin grafts could be applied for the treatment of large skin wounds or used as an in vitro wound-healing model. However, there is currently no skin replacement model that includes both, endothelial cells to simulate vascularization, and macrophages to regulate wound healing and tissue regeneration. Here, we describe for the first time a tissue-engineered, fully vascularized dermo-epidermal skin graft based on a fibrin hydrogel scaffold, using exclusively human primary cells. Read More

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http://dx.doi.org/10.1002/jbm.a.36648DOI Listing
February 2019
2 Reads

The thickness of poly-phenoxyethyl methacrylate (PHEMA) brush interferes with cellular behavior and function of myofibers.

J Biomed Mater Res A 2019 Feb 5. Epub 2019 Feb 5.

Guangdong Provincial Key Laboratory of Medical Biomechanics, Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

Introducing or grafting molecules onto biomaterial surfaces to regulate muscle cell destination via biophysical cues is one of the important steps for biomaterial design in muscle tissue engineering. Therefore, it is important to understand the interaction between myoblasts or myofibers with substrates modified by biomimetic layer with different thickness. In this study, we used a surface-induced atom transfer radical polymerization (SI-ATRP) method to synthetize and graft poly-phenoxyethyl methacrylate (PHEMA) brushes having different lengths on the glass substrates. Read More

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http://dx.doi.org/10.1002/jbm.a.36636DOI Listing
February 2019
1 Read

Engineering molecularly mobile polyrotaxane surfaces with heparin-binding EGF-like growth factors for improving hepatocyte functions.

J Biomed Mater Res A 2019 Feb 5. Epub 2019 Feb 5.

Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.

Hepatocytes in vitro may be useful for treating various types of liver diseases, but these cells immediately lose their functions. Here, we designed sulfonated-polyrotaxane (PRX) surfaces with immobilized heparin binding-epidermal growth factor-like growth factors (HB-EGFs) for improving hepatic functions. Sulfonated-PRX triblock copolymers, composed of sulfopropyl ether modified α-cyclodextrins (α-CDs) threaded onto a poly(ethylene glycol) (PEG) chain as a PRX segment and poly(benzyl methacrylate) at both terminals of the PEG as anchoring segments, were coated onto polystyrene surfaces by a drop cast method. Read More

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http://dx.doi.org/10.1002/jbm.a.36646DOI Listing
February 2019
1 Read

Redox-active injectable gel using polyion complex to achieve sustained release of exenatide and enhance therapeutic efficacy for the treatment of type 2 diabetes.

J Biomed Mater Res A 2019 Feb 5. Epub 2019 Feb 5.

Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba 305-8573, Japan.

To provide sustained release of exenatide and enhance therapeutic efficacy for the treatment of type 2 diabetes compared to the existing products for exenatide, we developed an exenatide-loaded, redox-active, injectable gel (Exe@RIG). This injectable gel is formed by a polyion complex (PIC) comprising three components, (1) cationic polyamine-poly(ethylene glycol)-polyamine triblock copolymer possessing reactive oxygen species (ROS)-scavenging moieties as side chains, (2) anionic poly(acrylic acid), and (3) exenatide. The mixture formed exenatide-loaded PIC flower micelles at room temperature, which immediately converted to a gel under physiological conditions. Read More

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http://dx.doi.org/10.1002/jbm.a.36647DOI Listing
February 2019

Influence of poly-L-lysine molecular weight on antibacterial efficacy in polymer multilayer films.

J Biomed Mater Res A 2019 Feb 4. Epub 2019 Feb 4.

School of Engineering, Brown University, Providence, RI.

Antibacterial coatings can prevent and treat medical device-associated infections. We examined the antibacterial properties of coatings assembled from poly-L-lysine (PLL) and hyaluronic acid (HA). (PLL/HA) films were fabricated using layer-by-layer assembly with three different PLL MWs, differentiated by number of repeat units, i. Read More

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http://dx.doi.org/10.1002/jbm.a.36645DOI Listing
February 2019

Modification of honeycomb bioceramic scaffolds for bone regeneration under the condition of excessive bone resorption.

J Biomed Mater Res A 2019 Feb 1. Epub 2019 Feb 1.

School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.

Gallium (Ga) ions have been clinically approved for treating the diseases caused by the excessive bone resorption through the systemic administration. Nevertheless, little attention has been given to the Ga-containing biomaterials for repairing bone defects under the pathological condition of excessive bone resorption. In the current study, for the first time the Ga-containing phosphate glasses (GPGs) were introduced to modify the honeycomb β-tricalcium phosphate (β-TCP) bioceramic scaffolds, which were prepared by an extrusion method. Read More

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http://dx.doi.org/10.1002/jbm.a.36644DOI Listing
February 2019
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Effect of cyclic compression on bone marrow mesenchymal stromal cells in tissue engineered cartilage scaffold.

J Biomed Mater Res A 2019 Feb 1. Epub 2019 Feb 1.

Department of Orthopedic Trauma, Hanover Medical School (MHH), OE 6230 Carl-Neuberg-Straße 1, D-30625 Hanover, Germany.

In this current study, a novel multilayer porous composite scaffold was fabricated with chitosan (CS), silk fibrin (SF) and nano-hydroxyapatite (n-HA). Scanning electron microscope (SEM) was utilized to detect the characteristics of the composed scaffold. Rat bone marrow stromal cells (rBMSC) were loaded onto the CS/SF/n-HA scaffold and cultured in a bioreactor under an on-off dynamic compression (10% compressive strain, 0. Read More

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http://dx.doi.org/10.1002/jbm.a.36642DOI Listing
February 2019
3.369 Impact Factor

Participation of Integrin β3 in Osteoblast Differentiation Induced by Titanium with Nano or Microtopography.

J Biomed Mater Res A 2019 Feb 1. Epub 2019 Feb 1.

Cell Culture Laboratory, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

The major role of integrins is to mediate cell adhesion but some of them are involved in the osteoblasts-titanium (Ti) interactions. In this study, we investigated the participation of integrins in osteoblast differentiation induced by Ti with nanotopography (Ti-Nano) and with microtopography (Ti-Micro). By using a PCR array, we observed that, compared with Ti-Micro, Ti-Nano upregulated the expression of five integrins in mesenchymal stem cells, including integrin β3, which increases osteoblast differentiation. Read More

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http://dx.doi.org/10.1002/jbm.a.36643DOI Listing
February 2019
1 Read

Fabrication of carbonate apatite honeycomb and its tissue response.

J Biomed Mater Res A 2019 Jan 31. Epub 2019 Jan 31.

Department of Oral Surgery, Institute of Biomedical Sciences, Tokushima University, 3-18-15 Kuramotocho, Tokushima, 770-8504, Japan.

Carbonate apatite (CO Ap) block can be used as a bone substitute because it can be remodeled to new natural bone in a manner conforming with the bone remodeling process. Among the many porous structures available, honeycomb structure is advantageous for rapid replacement of CO Ap to bone. In this study, the feasibility to fabricate a CO Ap honeycomb was studied, along with its initial tissue response in rabbit femur bone defect. Read More

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http://dx.doi.org/10.1002/jbm.a.36640DOI Listing
January 2019

Efficient intrahepatic tumor generation by cell sheet transplantation to fabricate orthotopic hepatocarcinoma-bearing model mice for drug testing.

J Biomed Mater Res A 2019 Jan 31. Epub 2019 Jan 31.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Kawada-cho 8-1, Shinjuku-ku, Tokyo, 162-8666, Japan.

Subcutaneous tumor-bearing mice are commonly used to evaluate antitumor activity in preclinical studies of anticancer drugs. However, these models often exhibit excessive antitumor responses to anticancer drug candidates. In this study, intrahepatic tumor-bearing mice as orthotopic tumor models were fabricated by transplanting hepatocarcinoma cell monolayers (sheets) to investigate differences in ectopic versus orthotopic antitumor response. Read More

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http://dx.doi.org/10.1002/jbm.a.36641DOI Listing
January 2019

Effect of dual-drug-releasing micelle-hydrogel composite on wound healing in vivo in full-thickness excision wound rat model.

J Biomed Mater Res A 2019 Jan 31. Epub 2019 Jan 31.

School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, 923-1292, Japan.

Wound healing is a complex process involving an intricate cascade of body responses. A composite dressing that would effectively target different stages of wound healing and regeneration is urgently needed. In the current study, we tested the efficacy of a previously prepared micelle-hydrogel composite loaded with two drugs, in full-thickness excision wound model in rat. Read More

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http://doi.wiley.com/10.1002/jbm.a.36639
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http://dx.doi.org/10.1002/jbm.a.36639DOI Listing
January 2019
7 Reads

PAM/GO/Gel/SA composite hydrogel conduit with bioactivity for repairing peripheral nerve injury.

J Biomed Mater Res A 2019 Jan 31. Epub 2019 Jan 31.

Key laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, 226001, Nantong, P.R. China.

The effective repair and functional recovery after peripheral nerve injury is still a hot topic in clinical research. The aim of this study was to construct a bioactive composite hydrogel conduit as a three-dimensional scaffold for the repair of rat sciatic nerve defects. The composite hydrogel conduit was fabricated by blending different volumes of polyacrylamide, graphene oxide, gelatin and sodium alginate(PAM/GO/Gel/SA,PGGS) and injecting into a self-made mold with an inner diameter of 2 mm and an outer diameter of 6 mm. Read More

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http://dx.doi.org/10.1002/jbm.a.36637DOI Listing
January 2019

Baghdadite Nanoparticle-Coated Poly L-Lactic Acid (PLLA) Ceramics Scaffold Improved Osteogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells.

J Biomed Mater Res A 2019 Jan 31. Epub 2019 Jan 31.

Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Bone repair has been a new approach in regenerative medicine especially by application of stem cells. Discovering a suitable combination of scaffolds to stimulate osteogenesis is one of the major concerns in this issue. Porous polymeric scaffolds such as Poly L-lactic Acid (PLLA) have been attracted a lot of attention because of their biodegradability. Read More

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http://dx.doi.org/10.1002/jbm.a.36638DOI Listing
January 2019
1 Read
3.369 Impact Factor

Revolutionary advances in 2-methacryloyloxyethyl phosphorylcholine polymers as biomaterials.

J Biomed Mater Res A 2019 Jan 30. Epub 2019 Jan 30.

Department of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

In the last 40 years, many strategies to fabricate biocompatible and antithrombogenic polymers have been proposed, especially in Japan. The development of one such polymers composed of 2-methacryloyloxyethyl phosphorylcholine unit, is described in this review, with specific examples of use in biomedical devices. These polymers are typically incorporated into other materials to effectively prevent unfavorable biological responses and reactions. Read More

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http://dx.doi.org/10.1002/jbm.a.36635DOI Listing
January 2019
1 Read

Effect of magnesium on reducing the UV-induced oxidative damage in marrow mesenchymal stem cells.

J Biomed Mater Res A 2019 Jan 30. Epub 2019 Jan 30.

Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China.

Oxidative stress could cause damage to lipids, proteins and DNA, which is induced by the imbalance between the production of reactive oxygen species (ROS) and the biological system ability to counteract or detoxify their harmful effects. The oxidative stress damage significantly contributes to a number of diseases. Magnesium (Mg) is endowed with a novel function of removing excess ROS by releasing H during the degradation. Read More

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http://dx.doi.org/10.1002/jbm.a.36634DOI Listing
January 2019
1 Read

Bioactive chitosan-based scaffolds with improved properties induced by dextran-grafted nano-maghemite and l-arginine amino acid.

J Biomed Mater Res A 2019 Jan 30. Epub 2019 Jan 30.

Department of Engineering for Innovation, University of Salento, Lecce, Italy.

Over the past years, fundamentals of magnetism opened a wide research area of interest, in the field of tissue engineering and regenerative medicine. The integration of magnetic nanoarchitectures into synthetic/natural scaffold formulations allowed obtaining "on demand" responsive structures able to guide the regeneration process. The aim of this work was the design and characterization of three-dimensional (3D) chitosan-based scaffolds containing dextran-grafted maghemite nanoarchitectures (DM) and functionalized with l-arginine (l-Arg) amino acid as bioactive agent. Read More

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http://dx.doi.org/10.1002/jbm.a.36633DOI Listing
January 2019

A hybrid small-diameter tube fabricated from decellularized aortic intima-media and electrospun fiber for artificial small-diameter blood vessel.

J Biomed Mater Res A 2019 Jan 30. Epub 2019 Jan 30.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

Hybrid small-diameter tubes were fabricated by wrapping decellularized aortic intima-media sheets around a tubular stainless steel mandrel with diameter 4 mm, and then by coating with electrospun segmented polyurethane. The synthetic coat was deposited uniformly to a thickness of about 0.5-3. Read More

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http://dx.doi.org/10.1002/jbm.a.36631DOI Listing
January 2019

Poly(ester amide) particles for controlled delivery of celecoxib.

J Biomed Mater Res A 2019 Jan 30. Epub 2019 Jan 30.

Bone and Joint Institute, The University of Western Ontario.

Many potential pharmacological treatments for osteoarthritis (OA) can result in undesirable side effects due to the systemic administration of drugs, making the direct delivery of drugs to joints an attractive alternative. Poly(ester amide)s (PEAs) have been shown to exhibit promising properties for the development of particle-based intra-articular delivery vehicles. However, a limited range of PEA structures has been investigated. Read More

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http://dx.doi.org/10.1002/jbm.a.36632DOI Listing
January 2019

Short-term evaluation of thromboresistance of a poly(ether ether ketone) (PEEK) mechanical heart valve with poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-grafted surface in a porcine aortic valve replacement model.

J Biomed Mater Res A 2019 Jan 28. Epub 2019 Jan 28.

Department of Biomedical Engineering, National Cerebral and Cardiovascular Center (NCVC) Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

Improved thromboresistance of mechanical valves is desired to decrease the risk of thromboembolism and thrombosis and reduce the dosage of anticoagulation with a vitamin K antagonist (e.g., warfarin). Read More

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http://dx.doi.org/10.1002/jbm.a.36628DOI Listing
January 2019
1 Read

Cell sheet tissue engineering: cell sheet preparation, harvesting/manipulation and transplantation.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, TWIns, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.

Cell sheet tissue engineering is a concept for creating transplantable two-dimensional (2D) and three-dimensional (3D) tissues and organs. This review describes three elements of cell sheet tissue engineering in terms of the chemical and physical effects of material surfaces and the interfacial properties of cell sheets: preparation, harvesting/manipulation and transplantation of cell sheets. An essential technology for the preparation of cell sheets is the use of a temperature-responsive cell culture surface, where the surface of tissue culture polystyrene (TCPS) dish is modified with thin layer of temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). Read More

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http://dx.doi.org/10.1002/jbm.a.36627DOI Listing
January 2019
3 Reads

Combinatorial effects of inorganic ions on adhesion and proliferation of osteoblast-like cells.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Division of Advanced Ceramics, Graduate School of Engineering, Nagoya Institute of Technology.

Combinatorial effects of three ions, namely silicate (Si), calcium (Ca) and magnesium (Mg) ions, on the adhesion and proliferation of MC3T3-E1 mouse osteoblast-like cells were evaluated. The cells were cultured in single-, dual- or triple-ion-conditioned culture media with systematically changed ion concentrations. The ranges of Si, Ca and Mg ion concentrations were set as 10-70, 80-400, and 25-500 ppm, respectively. Read More

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http://dx.doi.org/10.1002/jbm.a.36623DOI Listing
January 2019
1 Read

Guest editorial-40th anniversary of Japanese Society for Biomaterials.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Department of Biomedical Engineering, National Cerebral and Cardiovascular Center, Osaka, Japan.

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http://dx.doi.org/10.1002/jbm.a.36625DOI Listing
January 2019

How the Japanese Society for Biomaterials established interdisciplinary studies in biomaterials science.

Authors:
Osamu Suzuki

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, 4-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

The Japanese Society for Biomaterials (JSB) was established in December 1978, aiming to develop and improve science and technology regarding materials used in living organisms and their application. Currently, JSB plays important roles as a domestic and international society serving as a center for interdisciplinary studies on biomaterial science and its applied research. Our academic activities are wide-ranging, from basic science and clinical practice to post-application medical devices including the following: holding academic lectures, granting academic and other awards, publishing academic journals, developing guidelines for medical devices and bioassays, conducting research associated with clinical trials and studies, and participating in the World Biomaterials Congress and overseas academic meetings on biomaterials. Read More

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http://dx.doi.org/10.1002/jbm.a.36629DOI Listing
January 2019
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40 years of the Japanese Society for Biomaterials looking back at my term of office as the chairperson.

Authors:
Yoshito Ikada

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Emeritus Professor of Kyoto University.

The compatibility of artificial materials with living system, such as antithrombogenicity and antiimmunogenicity, has been an important issue in the field of the biomaterials researches at the early periods of the biomaterials research. After that, the bioabsorbable materials have been subsequently incorporated as biomaterials. As a result, biomaterial researchers started participating in the field of drug delivery system (DDS), and combining biomaterials and cells not only led to bioartificial organs, but also tissue engineering. Read More

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http://dx.doi.org/10.1002/jbm.a.36621DOI Listing
January 2019

Simulated body fluid and the novel bioactive materials derived from it.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Department of Biomedical Sciences, College of Life and Health Science, Chubu University, Kasugai, Aichi 487-8901, Japan.

Professor Larry Hench first reported that certain glasses are able to spontaneously bond to living bone in 1970. This discovery stimulated research into new kinds of bone-bonding materials. However, there were no guiding principles for this purpose, and many animals were sacrificed in the effort to establish them. Read More

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http://dx.doi.org/10.1002/jbm.a.36620DOI Listing
January 2019
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Visible-light-responsive antibacterial activity of Au-incorporated TiO layers formed on Ti-(0-10)at%Au alloys by air oxidation.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Department of Materials Processing, Tohoku University, 6-6-02 Aza Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan.

Rutile TiO layers were formed on substrates of Ti-(0-10)at%Au alloys by a simple process of air oxidation, and their antibacterial activities were evaluated under visible-light irradiation (λ ≥ 400 nm). Au was introduced into the TiO layers on Ti-(1-10)at%Au alloys and existed as both metallic Au nanoparticles and dissolved Au ions. The TiO layers that formed on Ti-5at%Au and Ti-10at%Au alloys exhibited visible-light photocatalytic activity, i. Read More

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http://dx.doi.org/10.1002/jbm.a.36624DOI Listing
January 2019

Evaluation of an elastic decellularized tendon-derived scaffold for the vascular tissue engineering application.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

Due to the limited success rate of currently available vascular replacements, tissue engineering has received tremendous attention in recent years. A main challenge in the field of regenerative medicine is creating a mechanically functional tissue with a well-organized extracellular matrix, particularly of collagen and elastin. In this study, the native collagen scaffold derived from decellularized tendon sections, as a scaffold having the potential to be used for vascular tissue engineering applications, was studied. Read More

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http://doi.wiley.com/10.1002/jbm.a.36622
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http://dx.doi.org/10.1002/jbm.a.36622DOI Listing
January 2019
4 Reads

Effect of calcium phosphate phases affecting the crosstalk between osteoblasts and osteoclasts in vitro.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Previous studies have reported that octacalcium phosphate (OCP) enhances osteoblast differentiation and osteoclast formation during the hydrolysis process to hydroxyapatite (HA). However, the crystal phases that affect the crosstalk between osteoclasts and osteoblasts are unknown, which should determine the bone substitute material's property of OCP. The present study was designed to investigate whether the chemical composition and crystal structure of calcium phosphates affect osteoclast formation and the osteoclast-osteoblast crosstalk. Read More

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http://dx.doi.org/10.1002/jbm.a.36626DOI Listing
January 2019
1 Read

Biomimetic mineralization using matrix vesicle nanofragments.

J Biomed Mater Res A 2019 Jan 24. Epub 2019 Jan 24.

Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

In vitro synthesis of bone tissue has been paid attention in recent years; however, current methods to fabricate bone tissue are still ineffective due to some remaining gaps in the understanding of real in vivo bone formation process, and application of the knowledge in bone synthesis. Therefore, the objectives of this study were first, to perform a systematic and ultrastructural investigation of the initial mineral formation during intramembranous ossification of mouse calvaria from a material scientists' viewpoint, and to develop novel mineralization methods based on the in vivo findings. First, the very initial mineral deposition was found to occur at embryonic day E14. Read More

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http://dx.doi.org/10.1002/jbm.a.36618DOI Listing
January 2019

Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation.

J Biomed Mater Res A 2019 Jan 24. Epub 2019 Jan 24.

Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, Osaka, Japan.

During the bone regeneration process, the anisotropic microstructure of bone tissue (bone quality) recovers much later than bone mass (bone quantity), resulting in severe mechanical dysfunction in the bone. Hence, restoration of bone microstructure in parallel with bone mass is necessary for ideal bone tissue regeneration; for this, development of advanced bifunctional biomaterials, which control both the quality and quantity in regenerated bone, is required. We developed novel oriented bioactive glass/poly(lactic acid) composite scaffolds by introducing an effective methodology for controlling cell alignment and proliferation, which play important roles for achieving bone anisotropy and bone mass, respectively. Read More

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http://doi.wiley.com/10.1002/jbm.a.36619
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http://dx.doi.org/10.1002/jbm.a.36619DOI Listing
January 2019
8 Reads

Surfactant-assisted-water-exposed versus surfactant-aqueous-solution-exposed electrospinning of novel super hydrophilic Polycaprolactone-based fibers: Cell culture studies.

J Biomed Mater Res A 2019 Jan 22. Epub 2019 Jan 22.

Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran.

Blend electrospun scaffolds composed of Polycaprolactone and Pluronic are suitable for bone tissue engineering due to their excellent biocompatibility and hydrophilicity. However, exceeding from certain amounts of Pluronic, surface enrichment of this polymer leads to segregation of Pluronic chains within the fiber, endangering the integrity and mechanical properties of the scaffold. In this article, a novel method of blend electrospinning has been employed using a parallel water supply, positioning the Pluronic chains on the surface, thus enhancing the miscibility within the fibers. Read More

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http://dx.doi.org/10.1002/jbm.a.36616DOI Listing
January 2019

Modulation of macrophage phenotype via phagocytosis of drug-loaded microparticles.

J Biomed Mater Res A 2019 Jan 22. Epub 2019 Jan 22.

School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania.

Monocyte-derived macrophages play a critical role in directing wound pathology following injury. Depending on their phenotype, macrophages also promote tissue regeneration. However, the therapeutic administration of macrophages with a controlled phenotype is challenging because macrophages are highly plastic and quickly revert to a detrimental, inflammatory phenotype in response to the environment of a damaged tissue. Read More

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http://dx.doi.org/10.1002/jbm.a.36617DOI Listing
January 2019

Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA.

J Biomed Mater Res A 2019 Jan 21. Epub 2019 Jan 21.

Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan.

Nonviral delivery of plasmid (p)DNA or messenger (m)RNA is a safe and promising therapeutic option to continuously supply therapeutic proteins into diseased tissues. In most cases of in vivo pDNA and mRNA delivery, these nucleic acids are loaded into carriers based on cationic polymers and/or lipids to prevent nuclease-mediated degradation before reaching target cells. The carriers should also evade host clearance mechanisms, including uptake by scavenger cells and filtration in the spleen. Read More

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http://dx.doi.org/10.1002/jbm.a.36614DOI Listing
January 2019
2 Reads

Chondrogenic differentiation of mouse induced pluripotent stem cells (iPSCs) using the three-dimensional culture with ultra-purified alginate gel (UPAL gel).

J Biomed Mater Res A 2019 Jan 21. Epub 2019 Jan 21.

Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

Since articular cartilages have rarely healed by themselves because of their characteristics of avascularity and low cell density, surgical intervention is ideal for patients with cartilaginous injuries. Because of structural characteristics of the cartilage tissue, a three-dimensional culture of stem cells in biomaterials is a favorable system on cartilage tissue engineering. Induced pluripotent stem cells (iPSCs) are a new cell source in cartilage tissue engineering for its characteristics of self-renewal capability and pluripotency. Read More

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http://dx.doi.org/10.1002/jbm.a.36615DOI Listing
January 2019
2 Reads

Fabricating large-scale three-dimensional constructs with living cells by processing with syringe needles.

J Biomed Mater Res A 2019 Apr 1;107(4):904-909. Epub 2019 Feb 1.

Department of Biomaterials Science, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan.

Three-dimensional (3D) cell constructs composed only of cells and cell-secreted extracellular matrix have been attractive biomaterials for tissue engineering technology; however, controlling construct morphology and eliminating dead cells after fabrication remain a challenge. It has been hypothesized that moderate stress could shape constructs and eliminate dead cells. The purpose of this study was to establish an easily available technology for shaping 3D cell constructs and eliminating dead cells postfabrication. Read More

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http://dx.doi.org/10.1002/jbm.a.36613DOI Listing
April 2019
1 Read

Aptamer-integrated α-Gal liposomes as bispecific agents to trigger immune response for killing tumor cells.

J Biomed Mater Res A 2019 Jan 16. Epub 2019 Jan 16.

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, China.

A novel bispecific α-Gal liposome was constructed by self-assembling AS1411 aptamers into the α-Gal containing liposomes. The α-Gal liposomes were prepared using cell membranes of red blood cells from rabbit, which are composed of cholesterol, phospholipids, and α-Gal glycolipids. AS1411 is a DNA aptamer with high specificity and affinity for nucleolin and could integrate into liposomes by the modification of cholesterol. Read More

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http://doi.wiley.com/10.1002/jbm.a.36609
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http://dx.doi.org/10.1002/jbm.a.36609DOI Listing
January 2019
2 Reads
3.369 Impact Factor

Engineered pH-responsive Hydrazone-carboxylate complexes-encapsulated 2D matrices for Cathepsin-mediated apoptosis in cancer.

J Biomed Mater Res A 2019 Jan 16. Epub 2019 Jan 16.

College of Chemical Engineering, Huaqiao University, Xiamen 361021, P. R. China.

Spurred by the current advancements in engineering various intelligent nanoparticle-based drug delivery systems, conjugation of drugs with the stimuli-responsive molecular switches has become one of the most efficient approaches to deliver a drug cargo in spatiotemporal controlled fashions. In this study, we fabricated an innovative pH-triggered Hydrazone-carboxylate complex of doxorubicin (Dox), which was subsequently encapsulated in the layered double hydroxide (LDH) nanoparticles for effective cancer therapeutics. These two-dimensional (2D) biodegradable matrices efficiently delivered Dox by pH-triggered release in the acidic lysosomal environment and their subsequent escape to cytosol. Read More

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http://dx.doi.org/10.1002/jbm.a.36610DOI Listing
January 2019

Combination of bioactive factors and IEIK13 self-assembling peptide hydrogel promotes cartilage matrix production by human nasal chondrocytes.

J Biomed Mater Res A 2019 Apr 31;107(4):893-903. Epub 2019 Jan 31.

Laboratory of Tissue Biology and Therapeutic Engineering (LBTI), CNRS UMR 5305, Institute for Biology and Chemistry of Proteins, Lyon, France.

Nasal reconstruction remains a challenge for every reconstructive surgeon. Alloplastic implants are proposed to repair nasal cartilaginous defects but they are often associated with high rates of extrusion and infection and poor biocompatibility. In this context, a porous polymeric scaffold filled with an autologous cartilage gel would be advantageous. Read More

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http://doi.wiley.com/10.1002/jbm.a.36612
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http://dx.doi.org/10.1002/jbm.a.36612DOI Listing
April 2019
4 Reads

Preparation of thermo/redox/pH-stimulative poly(N-isopropylacrylamide-co-N,N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors.

J Biomed Mater Res A 2019 Jan 16. Epub 2019 Jan 16.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.

Stimuli-sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this article, polymeric nanogel P (N-isopropylacrylamide-N,N '-dimethylaminoethyl methacrylate [NIPAM-DMAEMA]) (PND) with pH/redox/thermo-responsivenesses was synthesized by the in situ polymerization of NIPAM and DMAEMA for the controlled release of doxorubicin hydrochloride (DOX) and N,N '-bis(acryloyl)cystamine (BAC) and N,N '-methylenebisacrylamide (MBA) act as the crosslinkers, respectively. The structure, size, and zeta potential of PND-BAC and PND-MBA were further characterized. Read More

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http://dx.doi.org/10.1002/jbm.a.36611DOI Listing
January 2019
4 Reads
3.369 Impact Factor

Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/fibrinogen/bredigite nanofibrous membranes and their integration with osteoblasts for guided bone regeneration.

J Biomed Mater Res A 2019 Jan 12. Epub 2019 Jan 12.

Center for Nanofibers and Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore.

Guided bone regeneration (GBR) has been established to be an effective method for the repair of defective tissues, which is based on isolating bone defects with a barrier membrane for faster tissue reconstruction. The aim of the present study is to develop poly (hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/fibrinogen (FG)/bredigite (BR) membranes with applicability in GBR. BR nanoparticles were synthesized through a sol-gel method and characterized using transmission electron microscopy and X-ray diffractometer. Read More

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http://doi.wiley.com/10.1002/jbm.a.36607
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http://dx.doi.org/10.1002/jbm.a.36607DOI Listing
January 2019
1 Read

In vitro interaction of human Wharton's jelly mesenchymal stem cells with biomimetic 3-D scaffold.

J Biomed Mater Res A 2019 Jan 12. Epub 2019 Jan 12.

Aerospace Medicine Research Center, Aja University of Medical Sciences, Tehran, Iran.

Study of cell-biomaterial interaction is a crucial aspect of bone tissue engineering to find a state-of-the-art functional substitute. In present study, the Wharton's jelly mesenchymal stem cells (hWJ-MSCs) behavior on 3-D biomimetic nano-hydroxy apatite/ chitosan/gelatin (nHA/CS/Gel) scaffolds was investigated. The outcome was assessed by histological, biochemical and morphological tests. Read More

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http://dx.doi.org/10.1002/jbm.a.36608DOI Listing
January 2019
10 Reads
3.369 Impact Factor

Two-dimensional graphene oxide reinforced porous biodegradable polymeric nanocomposites for bone tissue engineering.

J Biomed Mater Res A 2019 Jan 11. Epub 2019 Jan 11.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, 11794, USA.

This study investigates the mechanical properties and in-vitro cytotoxicity of two-dimensional (2D) graphene oxide nanoribbons and nanoplatelets (GONRs and GONPs) reinforced porous polymeric nanocomposites. Highly porous poly(propylene fumarate) (PPF) nanocomposites were prepared by dispersing 0.2 wt. Read More

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http://dx.doi.org/10.1002/jbm.a.36606DOI Listing
January 2019