4,179 results match your criteria Journal of biomechanical engineering[Journal]


Three-dimensional kinematic coupling in the knee during normal walking.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

Accurate joint kinematics play an important role in estimating joint kinetics in musculoskeletal simulations. Bi-planar fluoroscopic (BPF) systems have been introduced to measure skeletal kinematics with six degrees of freedom. The purpose of this study was to model knee kinematic coupling using knee kinematics during walking, as measured by the BPF system. Read More

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http://dx.doi.org/10.1115/1.4043562DOI Listing

Basin of Attraction and Limit Cycle Amplitude of an Ankle-Hip Model of Balance on a Balance Board.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

ASME Fellow, Human-Centric Design Research Lab, Department of Mechanical Engineering, Texas Tech University, Lubbock, TX 79401.

The study of upright posture (UP) stability is of relevance to estimating risk of falls, especially among people with neuromuscular deficits. Several studies have addressed this problem from a system dynamic approach based on parameter bifurcation analyses, which provide the region of stability (RoS) and the delimiting bifurcation curves (usually Hopf and pitchfork) in some parameter-spaces. In contrast, our goal is to determine the effect of parameter changes on the size of the basin of attraction (BoA) of the UP equilibrium and the amplitude of the limit cycle oscillations (LCOs) emerging from the Hopf bifurcations (HBs). Read More

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http://dx.doi.org/10.1115/1.4043563DOI Listing

Regression models for the erector spinae muscle (ESM) cross-sectional area (CSA): Asymptomatic populations.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Associate Professor, Department of Industrial and Systems Engineering, Auburn University, Auburn, AL 36849, USA.

Understanding low back morphology is critical to understanding spinal loading and the underlying injury mechanisms, which helps to characterize risk and, therefore, minimize low back pain injuries. Individualized erector spinae muscle (ESM) cross-sectional area (CSA) allows biomechanics practitioners to calculate individualized force-generating capacities and spinal loadings for given tasks. The objective is to perform morphological analyses and then provide regression models to estimate the ESM CSA of an individual with his/her subject characteristics. Read More

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http://dx.doi.org/10.1115/1.4043558DOI Listing

Evaluation of Force Sensing Resistors for the Measurement of Interface Pressures in Lower Limb Prosthetics.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Department of Bioengineering, University of Washington, Seattle, WA 98195.

Understanding pressure distributions at the limb-socket interface is essential to the design and evaluation of prosthetic components for lower limb prosthesis users. Force sensing resistors (FSRs) are employed in prosthetics research to measure pressure at this interface due to their low cost, thin profile, and ease of use. While FSRs are known to be sensitive to many sources of error, few studies have systematically quantified these errors using test conditions relevant to lower limb prosthetics. Read More

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http://dx.doi.org/10.1115/1.4043561DOI Listing

Instability of Incompatible Bilayered Soft Tissues and the Role of Interface Conditions.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Faculty of Aerospace Engineering, Technion|Israel Institute of Technology.

Mechanical stability analysis is instructive in explaining biological processes like morphogenesis, organogenesis, and pathogenesis of soft tissues. Consideration of the layered, residually-stressed structure of tissues, requires accounting for the joint effects of interface conditions and layer incompatibility. This paper is concerned with the influence of imposed rate (incremental) interface conditions (RICs) on critical loads in soft tissues, within the context of linear bifurcation analysis. Read More

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http://dx.doi.org/10.1115/1.4043560DOI Listing

Personalized Design of Functional Gradient Bone Tissue Engineering Scaffold.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao St., Nanjing 210016, Jiangsu Province, People's Republic of China.

The porous structure of the natural bone not only has the characteristics of lightweight and high strength, but also is conducive to the growth of cells and tissues due to interconnected pores. In this paper, a novel gradient-controlled parametric modeling technology is presented to design bone tissue engineering (BTE) scaffold. First of all, the method functionalizes the pore distribution in the bone tissue, and reconstructs the pore distribution of the bone tissue in combination with the pathological analysis of the bone defect area of the individual patient. Read More

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http://dx.doi.org/10.1115/1.4043559DOI Listing

Transepidermal Potential of the Stretched Skin.

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki Aoba, Sendai 980-8579, Japan.

The electrical response of the skin to mechanical stretches is reported here. The electrical potential difference across the epidermis (TEP: Transepidermal Potential) of porcine skin samples subjected to cyclic stretching was measured in situ to observe electrochemical change in epidermal tissue. In addition to a conventional method of TEP measurement for the whole of skin sample, a probe-type system with a fine-needle salt bridge was used for direct measurement of TEP at a targeted local point of the skin. Read More

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http://biomechanical.asmedigitalcollection.asme.org/article.
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http://dx.doi.org/10.1115/1.4043522DOI Listing
April 2019
1 Read

On the simulation of mitral valve function in health, disease, and treatment.

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

Gorman Cardiovascular Research Group, Department of Surgery, University of Pennsylvania, Philadelphia, PA.

The mitral valve (MV) is the heart valve that regulates blood ?ow between the left atrium and left ventricle (LV). In situations where the MV fails to fully cover the left atrioventricular ori?ce during systole, the resulting regurgitation causes pulmonary congestion, leading to heart failure and/or stroke. The causes of MV insuf?ciency can be either primary (e. Read More

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http://biomechanical.asmedigitalcollection.asme.org/article.
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http://dx.doi.org/10.1115/1.4043552DOI Listing
April 2019
1 Read

Evaluating Plastic Deformation and Damage as Potential Mechanisms for Tendon Inelasticity using a Reactive Modeling Framework.

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

ASME Fellow, Department of Biomedical Engineering, Department of Mechanical Engineering, University of Delaware Newark, Delaware 19716.

Inelastic behaviors, such as softening, a progressive decrease in modulus before failure, occur in tendon and are important aspect in degeneration and tendinopathy. These inelastic behaviors are generally attributed to two potential mechanisms: plastic deformation and damage. However, it is not clear which is primarily responsible. Read More

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http://dx.doi.org/10.1115/1.4043520DOI Listing

Thermodynamic theory and experimental validation of a multiphase isochoric freezing process.

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

Department of Mechanical Engineering, University of California Berkeley, Berkeley CA, USA.

Freezing of the aqueous solutions that comprise biological materials, such as isotonic physiological saline, results in the formation of ice crystals and the generation of a hypertonic solution, both of which prove deleterious to biological matter. The field of modern cryopreservation, or preservation of biological matter at sub-freezing temperatures, emerged from the 1948 discovery that certain chemical additives such as glycerol, known as cryoprotectants, can protect cells from freeze-related damage by depressing the freezing point of water in solution. This gave rise to a slew of important medical applications, from the preservation of sperm and blood cells to the recent preservation of an entire liver, and current cryopreservation protocols thus rely heavily on the use of additive cryoprotectants. Read More

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http://biomechanical.asmedigitalcollection.asme.org/article.
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http://dx.doi.org/10.1115/1.4043521DOI Listing
April 2019
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Arterial Stiffness: Different Metrics, Different Meanings.

J Biomech Eng 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Engineering Yale University, New Haven, CT, USA; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA.

Findings from basic science and clinical studies agree that arterial stiffness is fundamental to both the mechanobiology and the biomechanics that dictate vascular health and disease. There is, therefore, an appropriately growing literature on arterial stiffness. Perusal of the literature reveals, however, that many different methods and metrics are used to quantify arterial stiffness, and reported values often differ by orders of magnitude and have different meanings. Read More

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http://dx.doi.org/10.1115/1.4043486DOI Listing

Using torque-angle and torque-velocity models to characterize elbow mechanical function: Modelling and applied aspects.

J Biomech Eng 2019 Apr 10. Epub 2019 Apr 10.

Univ Rennes, CNRS, INRIA, IRISA, UMR6074, F-35000 Rennes.

Characterization of muscle mechanism through the torque-angle and torque-velocity relationships is critical for human movement evaluation and simulation. In-vivo determination of these relationships through dynamometric measurements and modelling is based on physiological and mathematical aspects. However, no investigation regarding the effects of the mathematical model and the physiological parameters underneath these models was found. Read More

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http://dx.doi.org/10.1115/1.4043447DOI Listing

Assessing the disturbed flow and the transition to turbulence in the arteriovenous fistula.

J Biomech Eng 2019 Apr 10. Epub 2019 Apr 10.

EOC-Ente Ospedaliero Cantonale, Lugano, Switzerland.

The arteriovenous fistula (AVF) is the main form of vascular access for hemodialysis patients, but its maintenance is very challenging. Its failure is mainly related to intimal hyperplasia, leading to stenosis. The aim of this work is twofold: i) to perform a computational study for the comparison of the disturbed blood dynamics in different configurations of AVF and ii) to assess the amount of turbulence developed by the specific geometric configuration of AVF. Read More

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http://dx.doi.org/10.1115/1.4043448DOI Listing
April 2019
1 Read

Machine learning-based pre-impact fall detection model to discriminate various types of fall.

J Biomech Eng 2019 Apr 10. Epub 2019 Apr 10.

Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Republic of Korea, 2066 Seoburo, Jangangu, Suwon, Gyeonggi, 16419, Republic of Korea, Tel: +82-31-290-7827, Fax: +82-31-290-7830.

Preimpact fall detection can send alarm service faster to reduce long-lie conditions and decrease the risk of hospitalization. Detecting various types of fall to determine the impact site or direction prior to impact is important because it increases the chance of decreasing the incidence or severity of fall-related injuries. In this study, a robust preimpact fall detection model was developed to classify various activities and falls as multi-class and its performance was compared with the performance of previous developed models. Read More

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http://dx.doi.org/10.1115/1.4043449DOI Listing

Changes in Shear Modulus of the Lumbar Multifidus Muscle during Different Body Positions.

J Biomech Eng 2019 Apr 9. Epub 2019 Apr 9.

Department of Mechanical and Nuclear Engineering, College of Engineering, The Pennsylvania State University, State College, Pennsylvania, USA; Department of Biomedical Engineering. College of Engineering, The Pennsylvania State University, State College, Pennsylvania, USA.

Multifidus function is important for active stabilization of the spine, but it can be compromised in patients with chronic low back pain and other spine pathologies. Force production and strength of back muscles are often evaluated using isometric or isokinetic tests, which lack the ability to quantify multifidi contribution independent of the erector spinae and adjacent hip musculature. The objective of this study is to evaluate localized force production capability in multifidus muscle using ultrasound Shear Wave Elastography (SWE) in healthy individuals. Read More

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http://dx.doi.org/10.1115/1.4043443DOI Listing
April 2019
3 Reads

Simulated Tremor Propagation in the Upper Limb: From Muscle Activity to Joint Displacement.

J Biomech Eng 2019 Apr 9. Epub 2019 Apr 9.

Mechanical Engineering, Neuroscience, Brigham Young University.

Although tremor is the most common movement disorder, there are few non-invasive treatment options. Creating effective tremor suppression devices requires a knowledge of where tremor originates mechanically (which muscles) and how it propagates through the limb (to which degrees of freedom, DOF). To simulate tremor propagation, we created a simple model of the upper limb, with tremorogenic activity in the 15 major superficial muscles as inputs and tremulous joint displacement in the 7 major DOF as outputs. Read More

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http://dx.doi.org/10.1115/1.4043442DOI Listing
April 2019
1 Read

On the influence of the shoulder kinematic chain on joint kinematics and musculotendon lengths during wheelchair propulsion estimated from multibody kinematics optimization.

J Biomech Eng 2019 Apr 9. Epub 2019 Apr 9.

Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers ParisTech, 151 Boulevard de l'hôpital, 75013 Paris, France.

Multibody kinematic optimization is frequently used to assess shoulder kinematics during manual wheelchair (MWC) propulsion but multiple kinematics chains are available. It is hypothesized that these different kinematic chains affect marker tracking, shoulder kinematics and resulting musculotendon (MT) lengths. In this study, shoulder kinematics and MT lengths obtained from four shoulder kinematic chains (open-loop thorax-clavicle-scapula-humerus (M1), closed-loop with contact ellipsoid (M2), scapula rhythm from regression equations (M3), and a single ball-and- socket joint between the thorax and the humerus (M4) were compared. Read More

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http://dx.doi.org/10.1115/1.4043441DOI Listing
April 2019
2 Reads

Cardiac Protective Engineering.

Authors:
Shu Q Liu

J Biomech Eng 2019 Apr 8. Epub 2019 Apr 8.

Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston IL, 60208-3107.

Cardioprotective engineering is an emerging bioengineering discipline aiming to develop engineering strategies to optimize cardioprotective actions against cardiac injuries and disorders. Although there exist innate cardioprotective mechanisms capable of supporting cardiomyocyte survival in response to an insult, not all these mechanisms are optimized in promptness and effectiveness, suggesting the necessity of cardioprotective engineering. Various cardioprotective strategies have been developed and used in experimental and clinical investigations; however, few of these strategies have exerted a significant clinical impact. Read More

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http://dx.doi.org/10.1115/1.4043434DOI Listing
April 2019
2 Reads

Model First and Ask Questions Later: Confessions of a Reformed Experimentalist.

Authors:
Jeffrey W Holmes

J Biomech Eng 2019 Apr 8. Epub 2019 Apr 8.

Departments of Biomedical Engineering and Medicine, Robert M. Berne Cardiovascular Research Center, and Center for Engineering in Medicine, P.O. Box 800759, University of Virginia, Charlottesville, VA 22908.

This paper is an invited perspective written in association with the awarding of the 2018 American Society of Mechanical Engineers Van C. Mow Medal. Inspired by Professor Mow's collaboration with Professor Michael Lai and the role mathematical modeling played in their work on cartilage biomechanics, this article uses our group's work on myocardial infarct healing as an example of the potential value of models in modern experimental biomechanics. Read More

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http://dx.doi.org/10.1115/1.4043432DOI Listing

Functional Measures of Grip Strength and Gait Remain Altered Long-term in a Rat Model of Post-traumatic Elbow Contracture.

J Biomech Eng 2019 Apr 8. Epub 2019 Apr 8.

Department of Mechanical Engineering & Materials Science, Department of Orthopaedic Surgery, and Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO; 1 Brookings Drive, Campus Box 1185, St. Louis, MO 63130.

Post-traumatic joint contracture (PTJC) is a debilitating condition, particularly in the elbow. Previously, we established an animal model of elbow PTJC quantifying passive post-mortem joint mechanics and histological changes temporally. These results showed persistent motion loss similar to what is experienced in humans. Read More

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http://dx.doi.org/10.1115/1.4043433DOI Listing
April 2019
2 Reads

Effects of Collagenase type II on Vitreous Humor, an in-situ Rheological Study.

J Biomech Eng 2019 Apr 3. Epub 2019 Apr 3.

Department of Mechanical & Aerospace Engineering, Department of Bioengineering, University of California Los Angeles, Los Angeles, California, 90095.

The purpose of this study is to quantify the impact of enzyme activity on the vitreous humor structure over time to understand the mechanical characteristics of the vitreous humor gel. Changes in the mechanical behavior of the vitreous occur to many reasons including aging, which may lead to many vitreoretinal diseases. The degeneration of the vitreous has been studied; however, in-situ experimental procedures to validate the existing hypotheses are limited. Read More

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http://dx.doi.org/10.1115/1.4043358DOI Listing
April 2019
1 Read

The effect of oxidation on the mechanical response of isolated elastin and aorta.

J Biomech Eng 2019 Apr 3. Epub 2019 Apr 3.

Department of Mechanical Engineering, IIT Madras, Chennai 600036.

Oxidation of aorta by hydroxyl radicals produces structural changes in arterial proteins like elastin and collagen, which results in change in the mechanical response of aorta. In this paper, with a view to understand the effect of oxidation on the mechanical behavior of aorta and isolated elastin, a thermodynamically consistent constitutive model is developed within the framework of mixture theory to describe the changes in aorta and isolated elastin with oxidation. The model is then studied under uniaxial extension using experimental data from literature. Read More

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http://dx.doi.org/10.1115/1.4043355DOI Listing

Comparative study of wall shear stress at the ascending aorta for different mechanical heart valve prostheses.

J Biomech Eng 2019 Apr 3. Epub 2019 Apr 3.

School of Mathematics, Computer Science and Engineering, City, University of London, Northampton square, London, EC1V 0HB, UK.

An experimental study is reported which investigates the wall shear stress (WSS) distribution in a transparent model of the human aorta comparing a SJM Regent bileaflet mechanical heart valve (BMHV) with the Lapeyre-Triflo FURTIVA trileaflet mechanical heart valve (TMHV) in physiological pulsatile flow. Elastic micro-pillar structures, calibrated as WSS sensors by micro-Particle-Image-Velocimetry measurement, are applied to the wall along the ascending aorta (AAo). The peak WSS values in the BMHV are observed to be almost twice that of the values seen in the TMHV. Read More

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http://biomechanical.asmedigitalcollection.asme.org/article.
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http://dx.doi.org/10.1115/1.4043357DOI Listing
April 2019
1 Read

Muscle-tendon unit parameter estimation of a Hill-type musculoskeletal model based on experimentally obtained subject-specific torque profiles.

J Biomech Eng 2019 Apr 3. Epub 2019 Apr 3.

Sport Sciences, Department of Health Science and Technology, Aalborg University, Denmark, Niels Jernes Vej 12, 9220 Aalborg East, Denmark.

The aim of this study was to generate a subject-specific musculoskeletal muscle model, based on isometric and isovelocity measurements of the whole lower extremity. A two-step optimisation procedure is presented for optimising the muscle-tendon parameters for isometric and isovelocity joint torque profiles. A significant decrease in the differences between the experimental and model-predicted joint torques was obtained for both isometric and isovelocity cases. Read More

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http://dx.doi.org/10.1115/1.4043356DOI Listing
April 2019
1 Read

Deciphering the ?Art? in Modeling and Simulation of the Knee Joint.

J Biomech Eng 2019 Mar 30. Epub 2019 Mar 30.

Center for Orthopaedic Biomechanics and Department of Mechanical and Materials Engineering, University of Denver, Denver, Colorado, USA.

Recent explorations of knee biomechanics have benefited from computational modeling, specifically leveraging advancements in finite element analysis and rigid body dynamics of joint and tissue mechanics. A large number of models have emerged with different levels of fidelity in anatomical and mechanical representation. Adapted modeling and simulation processes vary widely, based on justifiable choices in relation to anticipated use of the model. Read More

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http://dx.doi.org/10.1115/1.4043346DOI Listing
March 2019
1 Read

MMP12 preferentially attenuates axial stiffening of aging arteries.

J Biomech Eng 2019 Mar 27. Epub 2019 Mar 27.

Center for Engineering MechanoBiology and the Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104.

Arterial stiffening is a hallmark of aging, but how aging affects the arterial response to pressure is still not completely understood, especially with regard to specific matrix metalloproteinases (MMPs). Here, we used pressure myography of carotid arteries from C57BL/6 mice to study the effects of age and MMP12, a major arterial elastase, on arterial biomechanics. Aging from 2 to 24 months leads to both circumferential and axial stiffening with stretch, and these changes are associated with an increased wall thickness, decreased inner radius, and a decreased in vivo axial stretch ratio (IVSR). Read More

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http://dx.doi.org/10.1115/1.4043322DOI Listing

2018 Year in Review.

Authors:

J Biomech Eng 2019 Mar 26. Epub 2019 Mar 26.

n/a. Read More

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http://dx.doi.org/10.1115/1.4043288DOI Listing

Numerical Investigation of Turbulence in Abdominal Aortic Aneurysms.

J Biomech Eng 2019 Mar 26. Epub 2019 Mar 26.

Laboratory for Aero & Hydrodynamics, Delft University of Technology, Leeghwaterstraat 21, 2628 CA, Delft, The Netherlands.

Computational fluid dynamics (CFD) is a powerful method to investigate aneurysms. The primary focus of most investigations has been to compute various hemodynamic parameters to assess the risk posed by an aneurysm. Despite the occurrence of transitional flow in aneurysms, turbulence has not received much attention. Read More

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http://dx.doi.org/10.1115/1.4043289DOI Listing
March 2019
1 Read

Bridging finite element and machine learning modeling: stress prediction of arterial walls in atherosclerosis.

J Biomech Eng 2019 Mar 26. Epub 2019 Mar 26.

Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, California, United States of America; Molecular Biophysics and Integrative Bioimaging Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.

Finite element and machine learning modeling are two predictive paradigms that have rarely been bridged. In this study, we develop a parametric model to generate arterial geometries and accumulate a database of over 12,000 finite element simulations of mechanical behaviour and stress distribution in these arterial models representative of atherosclerotic plaques. We formulate the training data to predict the maximum von Mises stress which could indicate risk of plaque rupture. Read More

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http://dx.doi.org/10.1115/1.4043290DOI Listing
March 2019
1 Read

In vivo Layer-specific Mechanical Characterization of Porcine Stomach Tissue using Ultrasound Elastography.

J Biomech Eng 2019 Mar 22. Epub 2019 Mar 22.

Center for Modeling, Simulation and Imaging in Medicine (CeMSIM), Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Mechanical, Aerospace, and Nuclear Engineering, , Rensselaer Polytechnic Institute, Troy, NY, USA.

This paper presents in vivo mechanical characterization of the muscularis, submucosa and mucosa of the porcine stomach wall under large deformation loading. This is important for the development of gastrointestinal pathology-specific surgical intervention techniques. The study is based on testing the cardiac and fundic glandular stomach regions using a custom-developed compression elastography setup. Read More

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http://dx.doi.org/10.1115/1.4043259DOI Listing
March 2019
2 Reads

Cholesterol-dependent Modulation of Stem Cell Biomechanics: Application to Adipogenesis.

J Biomech Eng 2019 Mar 22. Epub 2019 Mar 22.

Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019.

Cell mechanics has been shown to regulate stem cell differentiation. We have previously reported that altered cell stiffness of mesenchymal stem cells can delay or facilitate biochemically directed differentiation. One of the factors that can affect the cell stiffness is cholesterol. Read More

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http://dx.doi.org/10.1115/1.4043253DOI Listing

Computational Modeling of Developing Cartilage Using Experimentally Derived Geometries and Compressive Moduli.

J Biomech Eng 2019 Mar 15. Epub 2019 Mar 15.

Weldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907.

During chondrogenesis, tissue organization changes dramatically. We previously showed that the compressive moduli of chondrocytes increase concomitantly with extracellular matrix (ECM) stiffness, suggesting cells were remodeling to adapt to the surrounding environment. Due to the difficulty in analyzing the mechanical response of cells in situ, we sought to create an in silico model that would enable us to investigate why cell and ECM stiffness increased in tandem. Read More

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http://dx.doi.org/10.1115/1.4043208DOI Listing

In Silico Performance of a Recellularized Tissue Engineered Transcatheter Aortic Valve.

J Biomech Eng 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA 55905, phone: +1 (507)-266-5120.

Commercially available heart valves have many limitations, such as a lack of re-modeling, risk of calcification and thromboembolic problems. Many state-of-the-art tissue engineered heart valves rely on recellularization. Current in vitro testing is insufficient in characterizing a soon to be living valve. Read More

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http://dx.doi.org/10.1115/1.4043209DOI Listing
March 2019
2 Reads

A review of impact testing methods for headgear in sports: Considerations for improved prevention of head injury through research and standards.

J Biomech Eng 2019 Mar 12. Epub 2019 Mar 12.

Orthopaedic Injury Biomechanics Group, Departments of Mechanical Engineering and Orthopaedics, The University of British Columbia, Vancouver, BC, Canada; International Collaboration on Repair Discoveries (ICORD), The University of British Columbia, Vancouver, BC, Canada.

Standards for sports headgear were introduced as far back as the 1960s and many have remained substantially unchanged to present day. Since this time, headgear has virtually eliminated catastrophic head injuries such as skull fractures and changed the landscape of head injuries in sports. Mild traumatic brain injury (mTBI) is now a prevalent concern and the effectiveness of headgear in mitigating mTBI is inconclusive for most sports. Read More

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http://dx.doi.org/10.1115/1.4043140DOI Listing
March 2019
2 Reads

Editors' Choice Papers for 2018.

J Biomech Eng 2019 Mar 6. Epub 2019 Mar 6.

240 Skirkanich Hall 210 S. 33rd Street philadelphia, PA 19104-6321.

No abstract. Read More

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http://dx.doi.org/10.1115/1.4043072DOI Listing
March 2019
1 Read

On the Biomechanics of Cardiac S-looping: insights from modeling and perturbation studies.

J Biomech Eng 2019 Mar 6. Epub 2019 Mar 6.

Bioengineering Program, Union College, Schenectady, NY 12308.

Cardiac looping is an important embryonic developmental stage where the primitive heart tube (HT) twists into a configuration that more closely resembles the mature heart. Improper looping leads to congenital defects. We study cardiac s-looping wherein the primitive ventricle which lay superior to the atrium now assumes its definitive position inferior to it. Read More

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http://dx.doi.org/10.1115/1.4043077DOI Listing
March 2019
1 Read

Strain mapping from 4D ultrasound reveals complex remodeling in dissecting murine abdominal aortic aneurysms.

J Biomech Eng 2019 Mar 6. Epub 2019 Mar 6.

Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA.

Current in vivo abdominal aortic aneurysm imaging approaches tend to focus on maximum diameter but do not measure 3D vascular deformation or strain. Complex vessel geometries, heterogeneous wall compositions, and surrounding structures can all influence aortic strain. Improved understanding of complex aortic kinematics has the potential to increase our ability to predict aneurysm expansion and eventual rupture. Read More

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http://dx.doi.org/10.1115/1.4043075DOI Listing

Flow Dynamics in the Aortic Arch and Its Effect on the Arterial Input Function in Cardiac Computed Tomography.

J Biomech Eng 2019 Mar 6. Epub 2019 Mar 6.

Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287.

The arterial input function (AIF)-time-density curve (TDC) of contrast at the coronary ostia-plays a central role in contrast enhanced computed tomography angiography (CTA). This study employs computational modeling in a patient-specific aorta to investigate mixing and dispersion of contrast in the aortic arch (AA) and to compare the TDCs in the coronary ostium and the descending aorta. Here, we examine the validity of the use of TDC in the descending aorta as a surrogate for the AIF. Read More

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http://dx.doi.org/10.1115/1.4043076DOI Listing
March 2019
5 Reads

Relative Motion between the Helmet and Head in Football Impact Test.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

Center for Applied Biomechanics, Department of Mechanical and Aerospace Engineering, University of Virginia, 4040 Lewis and Clark Drive, Charlottesville, VA 22911, USA.

Approximately 1.6-3.8 million sports-related traumatic brain injuries occur each year in the US. Read More

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http://dx.doi.org/10.1115/1.4043038DOI Listing
March 2019
1 Read

Computational Study of Pulmonary Flow Patterns after Repair of Transposition of Great Arteries.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

Department of Mechanical and Aerospace Engineering, George Washington University, Washington DC, USA.

Patients that undergo the arterial switch operation (ASO) to repair transposition of great arteries (TGA) can develop abnormal pulmonary trunk morphology with significant long-term complications. In this study, cardiovascular magnetic resonance was combined with computational fluid dynamics to investigate the impact of the post-operative layout on the pulmonary flow patterns. Three ASO patients were analyzed and compared to a normal control. Read More

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http://biomechanical.asmedigitalcollection.asme.org/article.
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http://dx.doi.org/10.1115/1.4043034DOI Listing
March 2019
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Comparing Predictive Accuracy and Computational Costs for Viscoelastic Modeling of Spinal Cord Tissues.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

School of Biomedical Engineering, Colorado State University, Department of Mechanical Engineering, Colorado State University, Department of Clinical Sciences, Colorado State University, 1374 Campus Delivery, Fort Collins, CO 80523.

The constitutive equation used to characterize and model spinal tissues can significantly influence the conclusions from experimental and computational studies. Therefore, researchers must make critical judgements regarding the balance of computational efficiency and predictive accuracy necessary for their purposes. The objective of this study is to quantitatively compare the fitting and prediction accuracy of linear viscoelastic (LV), quasi-linear viscoelastic (QLV), and (fully) non-linear viscoelastic (NLV) modeling of spinal-cord-pia-arachnoid-construct (SCPC), isolated cord parenchyma, and isolated pia-arachnoid-complex (PAC) mechanics in order to better inform these judgements. Read More

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http://dx.doi.org/10.1115/1.4043033DOI Listing
March 2019
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The geometrical arrangement of knee constraints that makes natural motion possible: theoretical and experimental analysis.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

DIN - Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Viale Risorgimento 2, 40136, Bologna, Italy.

The study of the knee natural motion, namely the unresisted motion that the knee exhibits in absence of external loads, provides insights into the physiology of this articulation. The natural motion represents the baseline condition upon which deformations of its passive structures (i.e. Read More

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http://dx.doi.org/10.1115/1.4043028DOI Listing

The effects of dynamic loading on bone fracture healing under Ilizarov Circular Fixators.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

Rehabilitation Centre, The First Affiliated Hospital, Shenzhen University, Guangdong, P. R. China.

Early weight bearing appears to enhance bone fracture healing under Ilizarov Circular Fixators (ICFs). However, the role of early weight bearing in the healing process remains unclear. This study aims to provide insight into the effects of early weight bearing on healing of bone fractures stabilized with ICFs, with the aid of mathematical modelling. Read More

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http://dx.doi.org/10.1115/1.4043037DOI Listing

Spatial Dependency of Glenohumeral Joint Stability during Dynamic Unimanual and Bimanual Pushing and Pulling.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

North Carolina State University, 911 Oval Drive, Raleigh, NC 27606.

Degenerative wear to the glenoid from repetitive loading can reduce effective concavity depth and lead to future instability. Workspace design should consider glenohumeral stability to prevent initial wear. While stability has been previously explored for activities of daily living including push-pull tasks, whether stability is spatially dependent is unexplored. Read More

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http://dx.doi.org/10.1115/1.4043035DOI Listing
March 2019
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A Formulation for Fluid Structure-Interactions in FEBio Using Mixture Theory.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

Department of Mechanical Engineering, Columbia University, New York, NY 10027.

Many physiological systems involve strong interactions between fluids and solids, posing a signicant challenge when modeling biomechanics. The objective of this study was to implement a fluid-structure interaction (FSI) solver in the free, open-source finite element code FEBio (febio.org), that combined the existing solid mechanics and rigid body dynamics solver with a recently-developed computational fluid dynamics (CFD) solver. Read More

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http://dx.doi.org/10.1115/1.4043031DOI Listing
March 2019
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Computational Design and Optimization of Nerve Guidance Conduits for Improved Mechanical Properties and Permeability.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576.

Nerve guidance conduits (NGCs) are tubular tissue engineering scaffolds used for nerve regeneration. The poor mechanical properties and porosity have always compromised their performances for guiding and supporting axonal growth. Therefore, in order to improve the properties of NGCs, the computational design approach was adopted to investigate the effects of different NGC structural features on their various properties, and finally design an ideal NGC with mechanical properties matching human nerves and high porosity and permeability. Read More

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http://dx.doi.org/10.1115/1.4043036DOI Listing
March 2019
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Relative Nucleus Pulposus Area and Position Alters Disc Joint Mechanics.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

Department of Mechanical Engineering, University of California Berkeley, Etcheverry Hall, Berkeley, CA, 94720; Department of Orthopaedic Surgery, University of California, San Francisco.

Aging and degeneration of the intervertebral disc are noted by changes in tissue composition and geometry, including a decrease in nucleus pulposus (NP) area. The NP centroid is positioned slightly posterior of the disc's centroid, but the effect of NP size and location on disc joint mechanics is not well understood. We evaluated the effect of NP size and centroid location on disc joint mechanics under dual-loading modalities (i. Read More

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http://dx.doi.org/10.1115/1.4043029DOI Listing
March 2019
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Erratum.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

corso duca degli abruzzi 24 Turin, piedemont 10129 Italy.

On page 10, the sentence of the Discussion: "Additionally, we observed for the first time in implanted endograft a statistically significant positive correlation between AWSS and helicity intensity h2 (i.e., the highest the helicity intensity, the lower the WSS, and consequently, the higher the WSS-related risk). Read More

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http://dx.doi.org/10.1115/1.4043039DOI Listing
March 2019
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The Phan-Thien and Tanner model applied to the lubrication of knee prostheses.

J Biomech Eng 2019 Mar 5. Epub 2019 Mar 5.

Grupo Biomecánica Computacional, Facultad de Ingeniería, Universidad Nacional de Entre Ríos, Oro Verde, Argentina, Ruta Prov. 11 km 10. C.P. 3100. Oro Verde, Argentina.

This work aims to provide a contribution to determine a proper model for the study of fluid film lubrication for the reduction of knee prostheses failure due to polyethylene wear. The Phan-Thien and Tanner (PTT) rheological law and the elastic deformation of the articular surfaces were considered in this modelling. The governing equations were solved numerically for different geometries and different Weissenberg numbers. Read More

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http://dx.doi.org/10.1115/1.4043032DOI Listing
March 2019
2 Reads