1,441 results match your criteria Journal of biomaterials applications[Journal]


Applications of starch and its derivatives in bioceramics.

J Biomater Appl 2019 Apr 23:885328219844972. Epub 2019 Apr 23.

1 Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Kraków, Poland.

The recent developments in the area of using starch in ceramics cover such fields like ceramic powders synthesis, where starch can be a polymerizing agent in sol-gel method or substrate for carbon spheres in hydrothermal synthesis, traditional ceramics manufacturing in which starch and its derivatives are being used as binders, rheological modifiers or even strengthening agents, as well as porous ceramics and bioceramics where starch plays mostly a role of pore forming agent. Due to the low dimensional changes occurring during the consolidation process, starch can help to control porosity of the bioceramics, which leads to better mechanical properties of the final product. Because of the gelation at low temperatures, it can be used as eco-friendly cross-linking agent for the synthesis of bioceramics, which shortens the process, as well. Read More

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http://dx.doi.org/10.1177/0885328219844972DOI Listing

A novel 3D-printed silk fibroin-based scaffold facilitates tracheal epithelium proliferation in vitro.

J Biomater Appl 2019 Apr 20:885328219845092. Epub 2019 Apr 20.

1 Department of Otorhinolaryngology - Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai, China.

The functional epithelial regeneration is important for repairing tracheal defects. However, the potential of 3D-printed SF-based scaffolds for tracheal epithelial regeneration is still unknown. In this study, we developed a novel silk fibroin-based scaffold prepared by 3D printing of silk fibroin/hydroxypropyl methyl cellulose (SF/HPMC) thixotropic hydrogel and evaluated the tracheal epithelium proliferation on this scaffold in vitro. Read More

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http://dx.doi.org/10.1177/0885328219845092DOI Listing

Importance of the free amine groups in acellular scaffold during tissue repairing or regeneration process.

J Biomater Appl 2019 Apr 20:885328219843195. Epub 2019 Apr 20.

1 School of Chemical Engineering, Hebei University of Technology, Tianjin, China.

In addition to serve as a physical scaffold, acellular scaffold should be involved in tissue repair processes such as hemostasis, inflammation, proliferation, and remodeling/regeneration as a bioactive material. The biological activities of acellular scaffold related to free amine groups may have a great influence on tissue repairing process after in situ implantation. In order to investigate the role of free amine groups in acellular scaffold on tissue repairing/regeneration process, the amine-blocked acellular scaffolds and amine-unblocked acellular scaffolds were prepared by using bovine pericardia. Read More

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http://dx.doi.org/10.1177/0885328219843195DOI Listing

Sol-gel preparation of anti-bacterial and bioactive glass-ceramics.

J Biomater Appl 2019 Apr 16:885328219843901. Epub 2019 Apr 16.

School of Materials Science & Engineering, China University of Mining and Technology, Xuzhou, China.

Glass-ceramics were synthesized through the sol-gel method. The Thermogravimetry & Differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD), BET, Scanning electron microscope (SEM), bioactivity and turbidometric tests were used to characterize the properties of the glass-ceramics. The TG-DSC results showed that the nitrates could be decomposed completely when the bioactive glass xerogel precursor was heat treated at 750°C. Read More

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http://dx.doi.org/10.1177/0885328219843901DOI Listing
April 2019
1 Read

Targeted pharmacokinetics of polymeric micelles modified with glycyrrhetinic acid and hydrazone bond in H22 tumor-bearing mice.

J Biomater Appl 2019 Apr 16:885328219841487. Epub 2019 Apr 16.

College of Pharmacy, Jinzhou Medical University, Jinzhou, PR China.

Liver cancer is one of the most common malignant tumors. Chemotherapy drugs have been widely used in the anti-hepatoma research. However, low targeting efficiency and serious adverse reaction are their main drawbacks. Read More

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http://dx.doi.org/10.1177/0885328219841487DOI Listing

Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model.

J Biomater Appl 2019 Apr 16:885328219838382. Epub 2019 Apr 16.

Surgical & Orthopaedic Research Laboratories, University of New South Wales, Prince of Wales Hospital, Randwick, Australia.

Management of osseous and soft tissue dead space can be a significant challenge in the clinical setting. Calcium sulphate and calcium phosphate-based biomaterials are increasingly being used as alternatives to PMMA for local release of antibiotics, in particular to fill dead space following surgical debridement. This study aims to observe the in-vivo absorption characteristics and tissue response of three commercially available calcium sulphate-based materials combined with gentamicin in an established soft tissue rabbit model. Read More

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http://dx.doi.org/10.1177/0885328219838382DOI Listing

Simultaneous delivery of gene and chemotherapeutics via copolymeric micellar nanoparticles to overcome multiple drug resistance to promote synergistic tumor suppression.

J Biomater Appl 2019 Apr 10:885328219839254. Epub 2019 Apr 10.

5 School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China.

Combination of chemotherapy and small interfering RNA (siRNA)-based nanotherapeutics could cooperatively and effectively suppress multiple drug resistance in cancer development. Particularly, nano-delivery systems that efficiently encapsulate two or more therapeutic payloads to the tumor-targeted sites have been proven significantly. Here, we prepared a micellar nanoparticle formed by monomethoxy poly (ethylene glycol)-block-poly(ε-caprolactone)-block-poly(L-lysine)/cholesterol (mPEG-b-PCL-b-PLL/Chol, further abbr. Read More

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http://journals.sagepub.com/doi/10.1177/0885328219839254
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http://dx.doi.org/10.1177/0885328219839254DOI Listing
April 2019
3 Reads
2.197 Impact Factor

In vivo transplantation of stem cells with a genipin linked scaffold for tracheal construction.

J Biomater Appl 2019 Apr 10:885328219839193. Epub 2019 Apr 10.

1 Department of Cardiothoracic Surgery, Clinical medical college of Yangzhou University, Yangzhou, China.

To establish the procedures of genipin-linked scaffold for in situ tracheal reconstruction in a rabbit model, and to demonstrate whether stem cells can be further differentiated in the bioreactor in vivo. It will further provide an experimental and theoretical foundation for clinical application. Previously, in vitro evaluation proved the detergent-enzymatic method effectively removed stromal epithelial cells, and the number of nuclei was reduced significantly ( p < 0. Read More

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http://journals.sagepub.com/doi/10.1177/0885328219839193
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http://dx.doi.org/10.1177/0885328219839193DOI Listing
April 2019
3 Reads

Breathable hydrogel dressings containing natural antioxidants for management of skin disorders.

J Biomater Appl 2019 Apr;33(9):1265-1276

1 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.

Traditional wound dressings are not effective enough to regulate the moisture content and remove excessive exudate from the environment. Wet wound dressings formed from hydrogels such as alginate are widely used in clinical practice for treatment of skin disorders. Here, we functionalize alginate dressings with natural antioxidants such as curcumin and t-resveratrol to render them both anti-inflammatory and antibacterial. Read More

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http://dx.doi.org/10.1177/0885328218816526DOI Listing
April 2019
2.197 Impact Factor

Three-dimensional graphene foam as a conductive scaffold for cardiac tissue engineering.

J Biomater Appl 2019 Apr 8:885328219839037. Epub 2019 Apr 8.

1 Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Myocardial infarction is one of the major causes of mortality throughout the world. Cardiac scaffolds are tissue-engineered structures for the treatment of myocardial infarction and are employed for tissue support and cell delivery to the injured region. In this study, we fabricated nanostructured graphene foams as porous and biocompatible cardiac tissue-engineering scaffolds. Read More

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http://dx.doi.org/10.1177/0885328219839037DOI Listing
April 2019
4 Reads
2.197 Impact Factor

The role of orthosilicic acid-induced autophagy on promoting differentiation and mineralization of osteoblastic cells.

J Biomater Appl 2019 Apr 8:885328219837700. Epub 2019 Apr 8.

1 Department of Orthopedics, Qilu Hospital of Shandong University and Shandong University Spine and Spine Cord Disease Research Center, Shandong Province, China.

Silicon, an element, has been reported to possess various osteogenic biological functions. However, the precise cellular action mechanism of silicon in osteogenesis is elusive. Here, we examine whether autophagy is associated with the osteogenic differentiation and mineralization of preosteoblasts stimulated by orthosilicic acid (unique soluble form of silicon). Read More

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http://dx.doi.org/10.1177/0885328219837700DOI Listing

PLGA nanoparticle-based docetaxel/LY294002 drug delivery system enhances antitumor activities against gastric cancer.

J Biomater Appl 2019 Apr 5:885328219837683. Epub 2019 Apr 5.

1 The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.

Docetaxel (TXT) is acknowledged as one of the most important chemotherapy agents for gastric cancer (GC). PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. However, the hydrophobicity of TXT and the poor solubility and low bioavailability of LY294002 limit their clinical application. Read More

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http://dx.doi.org/10.1177/0885328219837683DOI Listing
April 2019
3 Reads

Mechanical and chemical characterisation of bioresorbable polymeric stent over two-year in vitro degradation.

J Biomater Appl 2019 Apr 5:885328219839591. Epub 2019 Apr 5.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.

Polymeric stent is a temporary cardiovascular scaffold, made of biodegradable poly (l-lactic) acid, to treat coronary artery stenosis, with expected resorption by the human body over two to three years. In this paper, the mechanical properties of a polymeric stent over two-year in vitro degradation were studied and characterised using atomic force microscopy and nanoindentation techniques, complemented with analyses of weight loss, gel permeation chromatography and differential scanning calorimetry. Atomic force microscopy assessed stent degradation at the surface, whilst nanoindentation was able to investigate the property at a greater depth into the material. Read More

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http://dx.doi.org/10.1177/0885328219839591DOI Listing

Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application.

J Biomater Appl 2019 Apr 1:885328219835361. Epub 2019 Apr 1.

Department of Pharmaceutical Engineering, School of Bioengineering and Food, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of industrial microbiology in Hubei, Hubei University of Technology, Wuhan, China.

Many studies have reported that silver has excellent antibacterial properties. However, silver ions can easily react with oxygen to form AgO, thus leading to a color change and a reduction in its anti-microbial characteristics. In this study, silver triethanolamine- (ST) loaded PVB/CO solution was prepared as a potential candidate liquid bandage. Read More

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http://journals.sagepub.com/doi/10.1177/0885328219835361
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http://dx.doi.org/10.1177/0885328219835361DOI Listing
April 2019
2 Reads

Silk fibroin coating through EDC/NHS crosslink is an effective method to promote graft remodeling of a polyethylene terephthalate artificial ligament.

J Biomater Appl 2019 Mar 18:885328219836625. Epub 2019 Mar 18.

1 Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China.

Anterior cruciate ligament reconstruction using polyethylene terephthalate artificial ligaments is one of the research hotspots in sports medicine but it is still challenging to achieve biological healing. The purpose of this study was to modify polyethylene terephthalate ligament with silk fibroin through ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/N-hydroxysuccinimide (NHS) crosslink and to investigate the performance of graft remodeling in vitro and in vivo. After silk fibroin coating, changes in the surface properties of ligament were characterized by scanning electron microscopy, attenuated total reflectance-Fourier transform infrared spectroscopy and water contact angle measurements. Read More

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http://dx.doi.org/10.1177/0885328219836625DOI Listing
March 2019
7 Reads

Doxorubicin-loaded FeO-ZIF-8 nano-composites for hepatocellular carcinoma therapy.

J Biomater Appl 2019 Mar 16:885328219836540. Epub 2019 Mar 16.

1 Department of Hepatobiliary Surgery, Institute of Advanced Surgical Technology and Engineering, Regenerative Medicine and Surgery Engineering Research Center of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Hepatocellular carcinoma (HCC) is one of the most common and malignant cancers and has no effective therapeutic approaches. Chemotherapeutic drug doxorubicin (DOX) is widely used for HCC therapy, but its application is limited by the clinical toxicity. In the present study, an FeO-ZIF-8 magnetic nano-composite was fabricated and used for DOX delivery for HCC therapy. Read More

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http://dx.doi.org/10.1177/0885328219836540DOI Listing
March 2019
2 Reads
2.197 Impact Factor

Biodegradable hybrid mesoporous silica nanoparticles for gene/chemo-synergetic therapy of breast cancer.

J Biomater Appl 2019 Mar 16:885328219835490. Epub 2019 Mar 16.

College of Bioengineering, Henan University of Technology, Zhengzhou, Henan, China.

Mesoporous silica nanoparticles have been extensively explored in anticancer nanomedicine due to their excellent biodegradability, which is one important focus in their further clinical translations. However, the traditional design concepts based on the functional modification with active groups cannot significantly improve the controlled drug release efficiency and anticancer effect. Herein, a molecularly organic-inorganic hybrid mesoporous silica nanoparticle (HMSN) nanocarrier coated with hyaluronic acid (HA) and polyethyleneimine (PEI) was constructed for the gene/chemo-synergetic therapy of breast cancer. Read More

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http://dx.doi.org/10.1177/0885328219835490DOI Listing

Anti-inflammatory and antimicrobial activity of bioactive hydroxyapatite/silver nanocomposites.

J Biomater Appl 2019 Mar 16:885328219835995. Epub 2019 Mar 16.

1 Facultad de Ciencias Biológicas. Universidad Autónoma de Nuevo León. Nuevo León, México.

Biomaterials are often used in orthopedic surgery like cavity fillings. However, related complications often require long-term systemic antibiotics, device removal, and extended rehabilitation. Hydroxyapatite/silver (HA/Ag) composites have been proposed as implantation biomaterials owing to the osteogenic properties of hydroxyapatite and to the antimicrobial efficiency of silver. Read More

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http://dx.doi.org/10.1177/0885328219835995DOI Listing
March 2019
2.197 Impact Factor

Clopidogrel eluting electrospun polyurethane/polyethylene glycol thromboresistant, hemocompatible nanofibrous scaffolds.

J Biomater Appl 2019 Mar 18:885328219832984. Epub 2019 Mar 18.

2 Polymer Science and Engineering Division, CSIR- National Chemical Laboratory, Pune, India.

Biomaterials used as blood-contacting material must be hemocompatible and exhibit lower thrombotic potential while maintaining hemostasis and angiogenesis. With the aim of developing thromboresistant, hemocompatible nanofibrous scaffolds, polyurethane/polyethylene glycol scaffolds incorporated with 1, 5, and 10 wt% Clopidogrel were fabricated and evaluated for their physiochemical properties, biocompatibility, hemocompatibility, and antithrombotic potential. The results of physicochemical characterization revealed the fabrication of nanometer-sized scaffolds with smooth surfaces. Read More

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http://dx.doi.org/10.1177/0885328219832984DOI Listing

Design and evaluation of a novel biodegradable inferior vena cava filter.

J Biomater Appl 2019 Mar 16;33(8):1060-1069. Epub 2019 Jan 16.

2 Shanghai MicroPort Medical (Group) Co., Ltd, Shanghai, China.

Inferior vena cava filter has been increasingly applied in clinical practice to prevent pulmonary embolism. Nowadays, various complications after implanting conventional filters seriously hinder clinical applications. Therefore, in this paper, a novel biodegradable inferior vena cava filter was designed based on biodegradable materials, which is an hourglass-like filter anchored inside a stent structure fixed by connecting fibers. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218824203
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http://dx.doi.org/10.1177/0885328218824203DOI Listing
March 2019
5 Reads

In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants.

J Biomater Appl 2019 Mar 12:885328219831044. Epub 2019 Mar 12.

1 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, USA.

Highly uniform silicon nanopore membranes were developed for applications in implantable bioartificial organs. A robust, readily scalable, non-fouling surface coating is required to enhance silicon nanopore membrane hemocompatibility. However, the coating must be ultrathin to keep the nanopores from occluding. Read More

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http://dx.doi.org/10.1177/0885328219831044DOI Listing
March 2019
1 Read

Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements.

J Biomater Appl 2019 Mar 9:885328219834656. Epub 2019 Mar 9.

1 Shenzhen Research Institute of Shandong University, Shenzhen, Guangdong, P.R. China.

Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing process. Read More

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http://dx.doi.org/10.1177/0885328219834656DOI Listing
March 2019
2.197 Impact Factor

Polyvinylchloride surface with enhanced cell/bacterial adhesion-resistant and antibacterial functions.

J Biomater Appl 2019 Mar 6:885328219834680. Epub 2019 Mar 6.

1 Department of Biomedical Engineering, Purdue School of Engineering and Technology Indiana University-Purdue University at Indianapolis.

This study reports synthesis and attachment of a novel antibacterial and hydrophilic polymer onto a polyvinylchloride surface via a simple and mild surface coating technique. The compound 3,4-dichloro-5-hydroxy-2(5H)-furanone was derivatized and copolymerized with N-vinylpyrrolidone. The copolymer was then covalently coated onto polyvinylchloride surface. Read More

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http://dx.doi.org/10.1177/0885328219834680DOI Listing

Zeolite-fibrin clot composite as a haemostatic agent for haemophilia A.

J Biomater Appl 2019 Feb 28:885328219832380. Epub 2019 Feb 28.

1 Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, China.

Zeolite is a multifunctional material, which recently exhibited promising prospects in emerging biological and medical applications. This study reported a new bio-inorganic hybrid of zeolite-fibrin clot composite serving as haemostatic agent in haemophilia A. The zeolite-fibrin clot composite promoted haemocompatibility and helped to achieve short clotting time both in vitro (22 ± 3 s vs. Read More

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http://dx.doi.org/10.1177/0885328219832380DOI Listing
February 2019
4 Reads

Hemostatic wound dressings: Predicting their effects by in vitro tests.

J Biomater Appl 2019 Apr 21;33(9):1285-1297. Epub 2019 Feb 21.

4 Department of Thoracic, Cardiac and Vascular Surgery, University Hospital Tuebingen, Tuebingen, Germany.

Background: Application of controlled in vitro techniques can be used as a screening tool for the development of new hemostatic agents allowing quantitative assessment of overall hemostatic potential.

Materials And Methods: Several tests were selected to evaluate the efficacy of cotton gauze, collagen, and oxidized regenerated cellulose for enhancing blood clotting, coagulation, and platelet activation.

Results: Visual inspection of dressings after blood contact proved the formation of blood clots. Read More

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http://dx.doi.org/10.1177/0885328219831095DOI Listing

Hydrogel materials for the application of islet transplantation.

J Biomater Appl 2019 Apr 21;33(9):1252-1264. Epub 2019 Feb 21.

2 Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mellitus and promoting insulin independence in patients, its widespread implementation has been severely constrained by instances of post-transplantation islet cell death, rejection, and severe adverse immune responses. Islet encapsulation is an active area of research aimed at shielding implanted islets from immunological rejection and inflammation while still allowing for effective insulin and nutrient exchange with donor cells. Read More

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http://dx.doi.org/10.1177/0885328219831391DOI Listing
April 2019
2 Reads
2.197 Impact Factor

Modifying release of poorly soluble active pharmaceutical ingredients with the amine functionalized SBA-16 type mesoporous materials.

J Biomater Appl 2019 Apr 21;33(9):1214-1231. Epub 2019 Feb 21.

1 Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Poznań, Poland.

SBA-16 and two modified SBA-16 type ordered mesoporous silica were used as the carriers for ibuprofen (anti-inflammatory drug) and furosemide (loop diuretic drug). Modification of the solid carrier was prepared with chitosan or N-3[(amino(poly-propylenoxy)]aminopropyltrimethoxysilane. The samples of carriers and carrier-drug loaded materials were characterized by X-ray diffraction, N adsorption, Fourier-transform infrared spectroscopy, thermogravimetry, and differential scanning calorimetry. Read More

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http://dx.doi.org/10.1177/0885328219830823DOI Listing
April 2019
2 Reads

A hydrogel derived from acellular blood vessel extracellular matrix to promote angiogenesis.

J Biomater Appl 2019 Feb 21:885328219831055. Epub 2019 Feb 21.

3 Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China*These authors contributed equally to this work.

The biocompatibility and bioactivity of injectable acellular extracellular matrix nominates its use as an optimal candidate for cell delivery, serving as a reconstructive scaffold. In this study, we investigated the feasibility of preparing a blood vessel matrix (BVM) hydrogel, which revealed its pro-angiogenic effects in vitro and its therapeutic effects in an in vivo skin flap model. Aortic and abdominal aortic arteries from pigs were acellularized by Triton-X 100 and confirmed by hematoxylin and eosin and 4,6-diamidino-2-phenylindole staining. Read More

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http://dx.doi.org/10.1177/0885328219831055DOI Listing
February 2019

Bioactive poly(ε-caprolactone) microspheres with tunable open pores as microcarriers for tissue regeneration.

J Biomater Appl 2019 Apr 19;33(9):1242-1251. Epub 2019 Feb 19.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.

Microparticles with porous structure can be applied as microcarriers for both cell culture and tissue regeneration. While well-controlled pore structure represents a critical challenge to be achieved. In the present study, in order to develop microcarriers for cell culture, a series of poly(ε-caprolactone) microspheres were fabricated with varied macroporous structures. Read More

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http://dx.doi.org/10.1177/0885328218825371DOI Listing
April 2019
1 Read

Efficacy of dextran and peptide-everolimus bi-directional stent.

J Biomater Appl 2019 Apr 18;33(9):1232-1241. Epub 2019 Feb 18.

Chonnam National University Hospital, 501-757, Gwangju, Republic of Korea.

Everolimus inhibits stent restenosis and the WKYMV (fluorescein isothiocyanate) peptide promotes endothelial homing. Dextran is a natural polymer that is widely used as a pharmaceutical agent. The purpose of this study was to develop a double-drug-coated stent using a bidirectional coating system and to examine the surface shape with in vitro experiments. Read More

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http://dx.doi.org/10.1177/0885328218822664DOI Listing

The impact of clay-based hypoxia mimetic hydrogel on human fibroblasts of the periodontal soft tissue.

J Biomater Appl 2019 Apr 13;33(9):1277-1284. Epub 2019 Feb 13.

1 Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Thixotropic clays have favorable properties for tissue regeneration. Hypoxia mimetic agents showed promising results in pre-clinical models for hard and soft tissue regeneration. It is unclear if clays can be used as carrier for hypoxia mimetic agent in a periodontal regenerative setting. Read More

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http://dx.doi.org/10.1177/0885328218821042DOI Listing

Titanium dioxide nanotubes of defined diameter enhance mesenchymal stem cell proliferation via JNK- and ERK-dependent up-regulation of fibroblast growth factor-2 by T lymphocytes.

J Biomater Appl 2019 Feb 5;33(7):997-1010. Epub 2018 Dec 5.

2 Department of Mechanical Engineering, Faculty of Engineering, Chulalongkorn University, Thailand.

Long-term clinical success of a titanium implant not only depends upon osseointegration between implant and bone surface but also on the response of host immune cells. Following implantation of biomaterials, an inflammatory response, including T lymphocyte response, is ostensibly initiated by implant-cell interaction. However, little is known about the responses of T lymphocytes to titanium dioxide nanotubes. Read More

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http://dx.doi.org/10.1177/0885328218816565DOI Listing
February 2019
1 Read

In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages.

J Biomater Appl 2019 Feb;33(7):935-945

1 School of Biomedical Engineering, Hubei University of Science and Technology, Xianning, China.

Macrophages as immunocyte are attracting more and more attention in cancer therapy. Our previous study observed that dimercaptosuccinic acid (DMSA)-coated FeO magnetic nanoparticles triggered comprehensive immune responses of mouse macrophages (RAW264.7 cells) and induced production of many kinds of cytokines. Read More

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http://dx.doi.org/10.1177/0885328218817939DOI Listing
February 2019
1 Read
2.197 Impact Factor

Immobilization of bone morphogenetic protein-2 to gelatin/avidin-modified hydroxyapatite composite scaffolds for bone regeneration.

J Biomater Appl 2019 Apr 10;33(9):1147-1156. Epub 2019 Feb 10.

7 Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin.

Bone scaffold surface characterization is important for improving cell adhesion, migration, and differentiation. In this study, bone morphogenetic protein-2 (BMP-2) was immobilized to the surface of the gelatin/hydroxyapatite composite using avidin-biotin binding system to produce a bone-tissue engineering scaffold. Firstly, hydroxyapatite particles reacted with hexamethylene diisocyanate and then the terminal group was converted into a primary amine group. Read More

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http://dx.doi.org/10.1177/0885328218820636DOI Listing

Corrosion and bone healing of Mg-Y-Zn-Zr-Ca alloy implants: Comparative in vivo study in a non-immobilized rat femoral fracture model.

J Biomater Appl 2019 Apr 7;33(9):1178-1194. Epub 2019 Feb 7.

1 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

Biodegradable magnesium (Mg) alloys exhibit improved mechanical properties compared to degradable polymers while degrading in vivo circumventing the complications of permanent metals, obviating the need for surgical removal. This study investigated the safety and efficacy of Mg-Y-Zn-Zr-Ca (WZ42) alloy compared to non-degradable Ti6Al4V over a 14-week follow-up implanted as pins to fix a full osteotomy in rat femurs and as wires wrapped around the outside of the femurs as a cerclage. We used a fully load bearing model allowing implants to intentionally experience realistic loads without immobilization. Read More

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http://dx.doi.org/10.1177/0885328219825568DOI Listing
April 2019
1 Read

Degradation and interaction with bone of magnesium alloy WE43 implants: A long-term follow-up in vivo rat tibia study.

J Biomater Appl 2019 Apr 7;33(9):1157-1167. Epub 2019 Feb 7.

2 Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

The aim of this in vivo study was to examine the degradation and biocompatibility of the WE43 magnesium alloy containing magnesium yttrium, rare earth elements, and zirconium over a one-year long-term follow-up period. Additionally, we compared anodized WE43 implants with monolithic ones and clarified the effect of the anodization. WE43 cylindrical implants with and without anodization (length, 10 mm; diameter, 0. Read More

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http://dx.doi.org/10.1177/0885328218822050DOI Listing

A feasibility study of biodegradable magnesium-aluminum-zinc-calcium-manganese (AZXM) alloys for tracheal stent application.

J Biomater Appl 2019 Mar 4;33(8):1080-1093. Epub 2019 Feb 4.

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, USA.

Airway obstruction conditions are relatively rarely observed in clinical settings but nevertheless, extremely challenging to handle, especially when observed in pediatric patients. Several surgical procedures, including tracheal resection, end-to-end tracheal anastomosis, and tracheoplasty, have been developed and practised of late, to treat airway obstruction. However, the clinical outcome is typically not satisfactory due to airway restenosis conditions that develop following surgery. Read More

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http://dx.doi.org/10.1177/0885328218824775DOI Listing
March 2019
7 Reads

Prussian blue-modified ferritin nanoparticles for effective tumor chemo-photothermal combination therapy via enhancing reactive oxygen species production.

J Biomater Appl 2019 Apr 2;33(9):1202-1213. Epub 2019 Feb 2.

1 School of Clinical Medicine, Xuzhou Medical University, Xuzhou, PR China.

To realize the photothermal therapy ability of Prussian blue-modified ferritin nanoparticles (PB-Ft NPs) and its synergistic effect with chemotherapy, PB-Ft NPs were synthesized by a simple surface double decomposition reaction. Mean sizes of ferritin and PB-Ft NPs were 10.4 nm and 12. Read More

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http://dx.doi.org/10.1177/0885328218825175DOI Listing
April 2019
3 Reads
2.197 Impact Factor

Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria.

J Biomater Appl 2019 Apr 21;33(9):1168-1177. Epub 2019 Jan 21.

7 College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou, China.

To investigate the osteogenesis of macro-pore sized bone scaffolds, biphasic calcium phosphate scaffolds with accurately controlled macro-pore size (0.8, 1.2, and 1. Read More

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http://dx.doi.org/10.1177/0885328218825177DOI Listing
April 2019
1 Read

Evaluation of biocompatibility and immunogenicity of micro/nanofiber materials based on tilapia skin collagen.

J Biomater Appl 2019 Mar 21;33(8):1118-1127. Epub 2019 Jan 21.

1 College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.

Type I collagen, used as a raw material, plays a pivotal role in the development of medical devices and tissue engineering. Due to the risk of zoonotic transmission and religious constraints for mammalian collagen, fish collagen gains increased attention and is widely seen as an alternative. In this study, two collagen micro/nanofiber materials, self-assembled collagen nanofiber and electrospun collagen nanofiber, were prepared by tilapia skin collagen and their biocompatibility and immunogenicity was thoroughly investigated. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218820180
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http://dx.doi.org/10.1177/0885328218820180DOI Listing
March 2019
6 Reads

Improving the anti-washout property of calcium phosphate cement by introducing konjac glucomannan/κ-carrageenan blend.

J Biomater Appl 2019 Mar 19;33(8):1094-1104. Epub 2019 Jan 19.

1 School of Materials Science and Engineering, South China University of Technology, Guangzhou, P. R. China.

Anti-washout calcium phosphate cement (CPC) was prepared by dissolving water-soluble konjac glucomannan (KGM) and κ-carrageenan (KC) blend in the cement liquid. The anti-washout property, setting time, compressive strength and in vitro cytocompatibility of the CPC modified with KGM/KC blend were evaluated. The results indicated that the CPC pastes modified with KGM/KC blend exhibited excellent anti-washout property. Read More

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http://dx.doi.org/10.1177/0885328218824762DOI Listing
March 2019
5 Reads

Fabrication and characterization of novel ethyl cellulose-grafted-poly (ɛ-caprolactone)/alginate nanofibrous/macroporous scaffolds incorporated with nano-hydroxyapatite for bone tissue engineering.

J Biomater Appl 2019 Mar 16;33(8):1128-1144. Epub 2019 Jan 16.

2 Department of Chemistry, University of Zanjan, Zanjan, Iran.

The major challenge of tissue regeneration is to develop three dimensional scaffolds with suitable properties which would mimic the natural extracellular matrix to induce the adhesion, proliferation, and differentiation of cells. Several materials have been used for the preparation of the scaffolds for bone regeneration. In this study, novel ethyl cellulose-grafted-poly (ɛ-caprolactone) (EC-g-PCL)/alginate scaffolds with different contents of nano-hydroxyapatite were prepared by combining electrospinning and freeze-drying methods in order to provide nanofibrous/macroporous structures with good mechanical properties. Read More

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http://dx.doi.org/10.1177/0885328218822641DOI Listing
March 2019
2 Reads
2.197 Impact Factor

Decellularized extracellular matrix microparticles seeded with bone marrow mesenchymal stromal cells for the treatment of full-thickness cutaneous wounds.

J Biomater Appl 2019 Mar 16;33(8):1070-1079. Epub 2019 Jan 16.

5 Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.

Extracellular matrix materials mechanically dissociated into submillimeter particles have a larger surface area than sheet materials and enhanced cellular attachment. Decellularized porcine mesothelial extracellular matrix microparticles were seeded with bone marrow-derived mesenchymal stromal cells and cultured in a rotating bioreactor. The mesenchymal stromal cells attached and grew to confluency on the microparticles. Read More

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http://dx.doi.org/10.1177/0885328218824759DOI Listing
March 2019
1 Read

Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis.

J Biomater Appl 2019 Mar 16;33(8):1053-1059. Epub 2019 Jan 16.

Sichuan University, West China Hospital, Department of Otolaryngology Head and Neck Surgery, Chengdu, Sichuan, China.

Background: Nasal endoscopic surgery is widely used for nasal diseases, including sinusitis and tumors. However, scar hyperplasia, nasal irritation, scab, and nasal obstruction delay nasal mucosal recovery, with prolonged cleaning exacerbating the patient's financial burden. Here, we presented a novel approach for the treatment of nasal mucosal defects, termed acellular dermal matrix. Read More

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http://dx.doi.org/10.1177/0885328218822636DOI Listing
March 2019
7 Reads

Erratum.

Authors:

J Biomater Appl 2019 Jan 15:885328219827162. Epub 2019 Jan 15.

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http://dx.doi.org/10.1177/0885328219827162DOI Listing
January 2019
1 Read

Early diagnosis of cerebral thrombosis by EGFP-EGF1 protein conjugated ferroferric oxide magnetic nanoparticles.

J Biomater Appl 2019 Apr 15;33(9):1195-1201. Epub 2019 Jan 15.

1 Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Cerebral thrombosis disease is a worldwide problem, with high rates of morbidity, disability, and mortality. Magnetic resonance imaging diffusion-weighted imaging was used as an important early diagnostic method for cerebral thrombotic diseases; however, its diagnosis time is 2 h after onset. In this study, we designed EGFP-EGF1-NP-FeO for earlier diagnosis of cerebral thrombosis by taking advantage of EGFP-EGF1 fusion protein, in which EGF1 can bind with tissue factor and enhanced green fluorescent protein has previously been widely used as a fluorescent protein marker. Read More

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http://dx.doi.org/10.1177/0885328218823475DOI Listing
April 2019
8 Reads

Identification of specific integrin cross-talk for dermal fibroblast cell adhesion using a mixed peptide-chitosan matrix.

J Biomater Appl 2019 Feb 12;33(7):893-902. Epub 2019 Jan 12.

2 Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

Extracellular matrix molecules are recognized by several integrin subtypes, making identification of cross-talk among different integrin subtypes difficult. Here, we evaluated the cross-talk of integrin subtypes using four different integrin-binding peptides (FIB1; integrin αvβ3/α5β1, A2G10; integrin α6β1, EF1zz; integrin α2β1, or 531; integrin α3β1) derived from extracellular matrix molecules. Various combinations of two different integrin-binding peptides were mixed and conjugated on a chitosan matrix at various molar ratios and were evaluated for cell attachment activity. Read More

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http://dx.doi.org/10.1177/0885328218823457DOI Listing
February 2019
2 Reads

Biofabrication of three-dimensional cellular structures based on gelatin methacrylate-alginate interpenetrating network hydrogel.

J Biomater Appl 2019 Mar 12;33(8):1105-1117. Epub 2019 Jan 12.

1 Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, TX, USA.

Hydrogels have been widely used as extracellular matrix materials in various three-dimensional bioprinting applications. However, they possess limitations such as insufficient mechanical integrity and strength, especially in the vascular applications requiring suture retention and tolerance of systemic intraluminal pressure. Interpenetrating network hydrogels are unique mixtures of two separate hydrogels with enhanced properties. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218823329
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http://dx.doi.org/10.1177/0885328218823329DOI Listing
March 2019
22 Reads

Mechanical and degradation properties of small-diameter vascular grafts in an in vitro biomimetic environment.

J Biomater Appl 2019 Mar 12;33(8):1017-1034. Epub 2019 Jan 12.

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, China.

Small-diameter vascular grafts may fail after implantation due to various reasons from mechanical and biological aspects. In order to evaluate the mechanical durability of small-diameter vascular grafts after implantation, an artificial vascular biomimetic environment that can simulate body temperature, the liquid environment outside the vessel, and continuous blood flow and pulsatile pressure was constructed. This device can be used as a "pre-test" prior to animal experiments to explore the changes of mechanical and degradation properties in the long-term in vivo environment. Read More

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http://dx.doi.org/10.1177/0885328218820751DOI Listing
March 2019
3 Reads

Epithelial cell functionality on electroconductive Fe/Sr co-doped biphasic calcium phosphate.

J Biomater Appl 2019 Mar 10;33(8):1035-1052. Epub 2019 Jan 10.

1 Laboratory for Biomaterials, Materials Research Center, Indian Institute of Science, Bangalore, India.

In the perspective of dental restorative applications, co-doped bioceramics have not been explored much. From the clinical perspective, a successful dental implant is expected to interact with peri-prosthetic bones, gingival tissue, and surrounding connective tissues. The interaction of implant and implant coating materials with bone tissue is well studied. Read More

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http://dx.doi.org/10.1177/0885328218821549DOI Listing
March 2019
5 Reads