1,413 results match your criteria Journal of biomaterials applications[Journal]


Bioactive poly(ε-caprolactone) microspheres with tunable open pores as microcarriers for tissue regeneration.

J Biomater Appl 2019 Feb 19:885328218825371. Epub 2019 Feb 19.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.

Microparticles with porous structure can be applied as microcarriers for both cell culture and tissue regeneration. While well-controlled pore structure represents a critical challenge to be achieved. In the present study, in order to develop microcarriers for cell culture, a series of poly(ε-caprolactone) microspheres were fabricated with varied macroporous structures. Read More

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http://dx.doi.org/10.1177/0885328218825371DOI Listing
February 2019

Efficacy of dextran and peptide-everolimus bi-directional stent.

J Biomater Appl 2019 Feb 18:885328218822664. Epub 2019 Feb 18.

Chonnam National University Hospital, 501-757, Gwangju, Republic of Korea.

Everolimus inhibits stent restenosis and the WKYMV (fluorescein isothiocyanate) peptide promotes endothelial homing. Dextran is a natural polymer that is widely used as a pharmaceutical agent. The purpose of this study was to develop a double-drug-coated stent using a bidirectional coating system and to examine the surface shape with in vitro experiments. Read More

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http://dx.doi.org/10.1177/0885328218822664DOI Listing
February 2019

The impact of clay-based hypoxia mimetic hydrogel on human fibroblasts of the periodontal soft tissue.

J Biomater Appl 2019 Feb 13:885328218821042. Epub 2019 Feb 13.

1 Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Thixotropic clays have favorable properties for tissue regeneration. Hypoxia mimetic agents showed promising results in pre-clinical models for hard and soft tissue regeneration. It is unclear if clays can be used as carrier for hypoxia mimetic agent in a periodontal regenerative setting. Read More

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http://dx.doi.org/10.1177/0885328218821042DOI Listing
February 2019

Titanium dioxide nanotubes of defined diameter enhance mesenchymal stem cell proliferation via JNK- and ERK-dependent up-regulation of fibroblast growth factor-2 by T lymphocytes.

J Biomater Appl 2019 Feb 5;33(7):997-1010. Epub 2018 Dec 5.

2 Department of Mechanical Engineering, Faculty of Engineering, Chulalongkorn University, Thailand.

Long-term clinical success of a titanium implant not only depends upon osseointegration between implant and bone surface but also on the response of host immune cells. Following implantation of biomaterials, an inflammatory response, including T lymphocyte response, is ostensibly initiated by implant-cell interaction. However, little is known about the responses of T lymphocytes to titanium dioxide nanotubes. Read More

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http://dx.doi.org/10.1177/0885328218816565DOI Listing
February 2019
1 Read

In vitro inhibition of tumor growth by low-dose iron oxide nanoparticles activating macrophages.

J Biomater Appl 2019 Feb;33(7):935-945

1 School of Biomedical Engineering, Hubei University of Science and Technology, Xianning, China.

Macrophages as immunocyte are attracting more and more attention in cancer therapy. Our previous study observed that dimercaptosuccinic acid (DMSA)-coated FeO magnetic nanoparticles triggered comprehensive immune responses of mouse macrophages (RAW264.7 cells) and induced production of many kinds of cytokines. Read More

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http://dx.doi.org/10.1177/0885328218817939DOI Listing
February 2019
2.197 Impact Factor

Immobilization of bone morphogenetic protein-2 to gelatin/avidin-modified hydroxyapatite composite scaffolds for bone regeneration.

J Biomater Appl 2019 Feb 10:885328218820636. Epub 2019 Feb 10.

7 Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin.

Bone scaffold surface characterization is important for improving cell adhesion, migration, and differentiation. In this study, bone morphogenetic protein-2 (BMP-2) was immobilized to the surface of the gelatin/hydroxyapatite composite using avidin-biotin binding system to produce a bone-tissue engineering scaffold. Firstly, hydroxyapatite particles reacted with hexamethylene diisocyanate and then the terminal group was converted into a primary amine group. Read More

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http://dx.doi.org/10.1177/0885328218820636DOI Listing
February 2019

Corrosion and bone healing of Mg-Y-Zn-Zr-Ca alloy implants: Comparative in vivo study in a non-immobilized rat femoral fracture model.

J Biomater Appl 2019 Feb 7:885328219825568. Epub 2019 Feb 7.

1 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

Biodegradable magnesium (Mg) alloys exhibit improved mechanical properties compared to degradable polymers while degrading in vivo circumventing the complications of permanent metals, obviating the need for surgical removal. This study investigated the safety and efficacy of Mg-Y-Zn-Zr-Ca (WZ42) alloy compared to non-degradable Ti6Al4V over a 14-week follow-up implanted as pins to fix a full osteotomy in rat femurs and as wires wrapped around the outside of the femurs as a cerclage. We used a fully load bearing model allowing implants to intentionally experience realistic loads without immobilization. Read More

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http://dx.doi.org/10.1177/0885328219825568DOI Listing
February 2019
1 Read

Degradation and interaction with bone of magnesium alloy WE43 implants: A long-term follow-up in vivo rat tibia study.

J Biomater Appl 2019 Feb 7:885328218822050. Epub 2019 Feb 7.

2 Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

The aim of this in vivo study was to examine the degradation and biocompatibility of the WE43 magnesium alloy containing magnesium yttrium, rare earth elements, and zirconium over a one-year long-term follow-up period. Additionally, we compared anodized WE43 implants with monolithic ones and clarified the effect of the anodization. WE43 cylindrical implants with and without anodization (length, 10 mm; diameter, 0. Read More

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http://dx.doi.org/10.1177/0885328218822050DOI Listing
February 2019

A feasibility study of biodegradable magnesium-aluminum-zinc-calcium-manganese (AZXM) alloys for tracheal stent application.

J Biomater Appl 2019 Feb 4:885328218824775. Epub 2019 Feb 4.

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, USA.

Airway obstruction conditions are relatively rarely observed in clinical settings but nevertheless, extremely challenging to handle, especially when observed in pediatric patients. Several surgical procedures, including tracheal resection, end-to-end tracheal anastomosis, and tracheoplasty, have been developed and practised of late, to treat airway obstruction. However, the clinical outcome is typically not satisfactory due to airway restenosis conditions that develop following surgery. Read More

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http://dx.doi.org/10.1177/0885328218824775DOI Listing
February 2019
2 Reads

Prussian blue-modified ferritin nanoparticles for effective tumor chemo-photothermal combination therapy via enhancing reactive oxygen species production.

J Biomater Appl 2019 Feb 2:885328218825175. Epub 2019 Feb 2.

1 School of Clinical Medicine, Xuzhou Medical University, Xuzhou, PR China.

To realize the photothermal therapy ability of Prussian blue-modified ferritin nanoparticles (PB-Ft NPs) and its synergistic effect with chemotherapy, PB-Ft NPs were synthesized by a simple surface double decomposition reaction. Mean sizes of ferritin and PB-Ft NPs were 10.4 nm and 12. Read More

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http://dx.doi.org/10.1177/0885328218825175DOI Listing
February 2019
1 Read
2.197 Impact Factor

Osteogenesis of 3D printed macro-pore size biphasic calcium phosphate scaffold in rabbit calvaria.

J Biomater Appl 2019 Jan 21:885328218825177. Epub 2019 Jan 21.

7 College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou, China.

To investigate the osteogenesis of macro-pore sized bone scaffolds, biphasic calcium phosphate scaffolds with accurately controlled macro-pore size (0.8, 1.2, and 1. Read More

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http://dx.doi.org/10.1177/0885328218825177DOI Listing
January 2019

Evaluation of biocompatibility and immunogenicity of micro/nanofiber materials based on tilapia skin collagen.

J Biomater Appl 2019 Jan 21:885328218820180. Epub 2019 Jan 21.

1 College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.

Type I collagen, used as a raw material, plays a pivotal role in the development of medical devices and tissue engineering. Due to the risk of zoonotic transmission and religious constraints for mammalian collagen, fish collagen gains increased attention and is widely seen as an alternative. In this study, two collagen micro/nanofiber materials, self-assembled collagen nanofiber and electrospun collagen nanofiber, were prepared by tilapia skin collagen and their biocompatibility and immunogenicity was thoroughly investigated. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218820180
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http://dx.doi.org/10.1177/0885328218820180DOI Listing
January 2019
4 Reads

Improving the anti-washout property of calcium phosphate cement by introducing konjac glucomannan/κ-carrageenan blend.

J Biomater Appl 2019 Jan 19:885328218824762. Epub 2019 Jan 19.

1 School of Materials Science and Engineering, South China University of Technology, Guangzhou, P. R. China.

Anti-washout calcium phosphate cement (CPC) was prepared by dissolving water-soluble konjac glucomannan (KGM) and κ-carrageenan (KC) blend in the cement liquid. The anti-washout property, setting time, compressive strength and in vitro cytocompatibility of the CPC modified with KGM/KC blend were evaluated. The results indicated that the CPC pastes modified with KGM/KC blend exhibited excellent anti-washout property. Read More

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http://dx.doi.org/10.1177/0885328218824762DOI Listing
January 2019
1 Read

Fabrication and characterization of novel ethyl cellulose-grafted-poly (ɛ-caprolactone)/alginate nanofibrous/macroporous scaffolds incorporated with nano-hydroxyapatite for bone tissue engineering.

J Biomater Appl 2019 Jan 16:885328218822641. Epub 2019 Jan 16.

2 Department of Chemistry, University of Zanjan, Zanjan, Iran.

The major challenge of tissue regeneration is to develop three dimensional scaffolds with suitable properties which would mimic the natural extracellular matrix to induce the adhesion, proliferation, and differentiation of cells. Several materials have been used for the preparation of the scaffolds for bone regeneration. In this study, novel ethyl cellulose-grafted-poly (ɛ-caprolactone) (EC-g-PCL)/alginate scaffolds with different contents of nano-hydroxyapatite were prepared by combining electrospinning and freeze-drying methods in order to provide nanofibrous/macroporous structures with good mechanical properties. Read More

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http://dx.doi.org/10.1177/0885328218822641DOI Listing
January 2019
2.197 Impact Factor

Decellularized extracellular matrix microparticles seeded with bone marrow mesenchymal stromal cells for the treatment of full-thickness cutaneous wounds.

J Biomater Appl 2019 Jan 16:885328218824759. Epub 2019 Jan 16.

5 Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.

Extracellular matrix materials mechanically dissociated into submillimeter particles have a larger surface area than sheet materials and enhanced cellular attachment. Decellularized porcine mesothelial extracellular matrix microparticles were seeded with bone marrow-derived mesenchymal stromal cells and cultured in a rotating bioreactor. The mesenchymal stromal cells attached and grew to confluency on the microparticles. Read More

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http://dx.doi.org/10.1177/0885328218824759DOI Listing
January 2019

Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis.

J Biomater Appl 2019 Jan 16:885328218822636. Epub 2019 Jan 16.

Sichuan University, West China Hospital, Department of Otolaryngology Head and Neck Surgery, Chengdu, Sichuan, China.

Background: Nasal endoscopic surgery is widely used for nasal diseases, including sinusitis and tumors. However, scar hyperplasia, nasal irritation, scab, and nasal obstruction delay nasal mucosal recovery, with prolonged cleaning exacerbating the patient's financial burden. Here, we presented a novel approach for the treatment of nasal mucosal defects, termed acellular dermal matrix. Read More

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http://dx.doi.org/10.1177/0885328218822636DOI Listing
January 2019
2 Reads

Erratum.

Authors:

J Biomater Appl 2019 Jan 15:885328219827162. Epub 2019 Jan 15.

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http://dx.doi.org/10.1177/0885328219827162DOI Listing
January 2019

Early diagnosis of cerebral thrombosis by EGFP-EGF1 protein conjugated ferroferric oxide magnetic nanoparticles.

J Biomater Appl 2019 Jan 15:885328218823475. Epub 2019 Jan 15.

1 Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China.

Cerebral thrombosis disease is a worldwide problem, with high rates of morbidity, disability, and mortality. Magnetic resonance imaging diffusion-weighted imaging was used as an important early diagnostic method for cerebral thrombotic diseases; however, its diagnosis time is 2 h after onset. In this study, we designed EGFP-EGF1-NP-FeO for earlier diagnosis of cerebral thrombosis by taking advantage of EGFP-EGF1 fusion protein, in which EGF1 can bind with tissue factor and enhanced green fluorescent protein has previously been widely used as a fluorescent protein marker. Read More

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http://dx.doi.org/10.1177/0885328218823475DOI Listing
January 2019
3 Reads

Identification of specific integrin cross-talk for dermal fibroblast cell adhesion using a mixed peptide-chitosan matrix.

J Biomater Appl 2019 Feb 12;33(7):893-902. Epub 2019 Jan 12.

2 Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

Extracellular matrix molecules are recognized by several integrin subtypes, making identification of cross-talk among different integrin subtypes difficult. Here, we evaluated the cross-talk of integrin subtypes using four different integrin-binding peptides (FIB1; integrin αvβ3/α5β1, A2G10; integrin α6β1, EF1zz; integrin α2β1, or 531; integrin α3β1) derived from extracellular matrix molecules. Various combinations of two different integrin-binding peptides were mixed and conjugated on a chitosan matrix at various molar ratios and were evaluated for cell attachment activity. Read More

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http://dx.doi.org/10.1177/0885328218823457DOI Listing
February 2019

Biofabrication of three-dimensional cellular structures based on gelatin methacrylate-alginate interpenetrating network hydrogel.

J Biomater Appl 2019 Jan 12:885328218823329. Epub 2019 Jan 12.

1 Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, TX, USA.

Hydrogels have been widely used as extracellular matrix materials in various three-dimensional bioprinting applications. However, they possess limitations such as insufficient mechanical integrity and strength, especially in the vascular applications requiring suture retention and tolerance of systemic intraluminal pressure. Interpenetrating network hydrogels are unique mixtures of two separate hydrogels with enhanced properties. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218823329
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http://dx.doi.org/10.1177/0885328218823329DOI Listing
January 2019
12 Reads

Mechanical and degradation properties of small-diameter vascular grafts in an in vitro biomimetic environment.

J Biomater Appl 2019 Jan 12:885328218820751. Epub 2019 Jan 12.

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, China.

Small-diameter vascular grafts may fail after implantation due to various reasons from mechanical and biological aspects. In order to evaluate the mechanical durability of small-diameter vascular grafts after implantation, an artificial vascular biomimetic environment that can simulate body temperature, the liquid environment outside the vessel, and continuous blood flow and pulsatile pressure was constructed. This device can be used as a "pre-test" prior to animal experiments to explore the changes of mechanical and degradation properties in the long-term in vivo environment. Read More

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http://dx.doi.org/10.1177/0885328218820751DOI Listing
January 2019
2 Reads

Epithelial cell functionality on electroconductive Fe/Sr co-doped biphasic calcium phosphate.

J Biomater Appl 2019 Jan 10:885328218821549. Epub 2019 Jan 10.

1 Laboratory for Biomaterials, Materials Research Center, Indian Institute of Science, Bangalore, India.

In the perspective of dental restorative applications, co-doped bioceramics have not been explored much. From the clinical perspective, a successful dental implant is expected to interact with peri-prosthetic bones, gingival tissue, and surrounding connective tissues. The interaction of implant and implant coating materials with bone tissue is well studied. Read More

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http://dx.doi.org/10.1177/0885328218821549DOI Listing
January 2019

A novel curcumin-loaded nanoparticle restricts atherosclerosis development and promotes plaques stability in apolipoprotein E deficient mice.

J Biomater Appl 2019 Feb 12;33(7):946-954. Epub 2018 Dec 12.

1 School of Biological Science and Technology, University of Jinan, Jinan, China.

Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of its low aqueous solubility and poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(ε-caprolactone) copolymer nanoparticle loading curcumin (Cur-NPs) which could improve solubility and release property of curcumin. In the present study, we further evaluated its anti-atherosclerotic effect in apolipoprotein E mice. Read More

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http://dx.doi.org/10.1177/0885328218815328DOI Listing
February 2019
6 Reads

Electrospun PCL, gold nanoparticles, and soy lecithin composite material for tissue engineering applications.

J Biomater Appl 2019 Feb 6;33(7):979-988. Epub 2018 Dec 6.

Department of Bioengineering, University of Missouri, Columbia, MO, USA.

Soy lecithin has been shown to play a critical role in cell signaling and cellular membrane structure. In addition, it has been shown to increase biocompatibility, hydrophilicity, and decrease cytotoxicity. Gold nanoparticles have also shown to improve cellularity. Read More

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http://dx.doi.org/10.1177/0885328218815807DOI Listing
February 2019
2 Reads

Use of thioglycerol on porous polyurethane as an effective theranostic capping agent for bone tissue engineering.

J Biomater Appl 2019 Feb 11;33(7):955-966. Epub 2018 Dec 11.

Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.

Thiolated biodegradable polyurethane (TG-DPU) was synthesized using a one-pot reaction with thioglycerol adopted as a functionalized chain extender. After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2. The interaction between TG-DPU and BMP-2, so-called bioconjugates, was investigated using X-ray photoelectron spectroscopy analysis; the appearance of disulfide (S-S) linkage indicated the formation of a polymer/growth factor conjugate system. Read More

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http://dx.doi.org/10.1177/0885328218817173DOI Listing
February 2019
1 Read

Effect of varying the crosslinking degree of a pericardial implant with oligourethane on the repair of a rat full-thickness abdominal wall defect.

J Biomater Appl 2019 Feb 10;33(7):903-914. Epub 2018 Dec 10.

1 División de Ciencias Ingenierías, Universidad de Guanajuato, León Guanajuato, Mexico.

The stability and bioactivity of biologic implants rely mainly on the control of the crosslinking process of collagen. However, the most common methods have no control on the crosslinking degree producing it excessively. This study outlines the role of crosslinking of collagen-based implants with oligourethane on the host response following reconstruction of a rat full-thickness abdominal wall defect. Read More

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http://dx.doi.org/10.1177/0885328218817890DOI Listing
February 2019
2 Reads

Fabrication, in vitro and in vivo studies of bilayer composite membrane for periodontal guided tissue regeneration.

J Biomater Appl 2019 Feb 3;33(7):967-978. Epub 2018 Dec 3.

1 Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan.

Development of a guided occlusive biodegradable membrane with controlled morphology in order to restrict the ingrowth of epithelial cells is still a challenge in dental tissue engineering. A bilayer membrane with a non-porous upper layer (polyurethane) and porous lower layer (polycaprolactone and bioactive glass composite) with thermoelastic properties to sustain surgery treatment was developed by lyophilization. Morphology, porosity, and layers attachment were controlled by using the multi-solvent system. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218814986
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http://dx.doi.org/10.1177/0885328218814986DOI Listing
February 2019
8 Reads
2.197 Impact Factor

Isoniazid-loaded chitosan/carbon nanotubes microspheres promote secondary wound healing of bone tuberculosis.

J Biomater Appl 2019 Feb 3;33(7):989-996. Epub 2018 Dec 3.

1 Department of burn, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross many kinds of physiological barriers. Read More

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http://dx.doi.org/10.1177/0885328218814988DOI Listing
February 2019
2.197 Impact Factor

Structure and properties of nano-hydroxyapatite/poly(butylene succinate) porous scaffold for bone tissue engineering prepared by using ethanol as porogen.

J Biomater Appl 2019 Jan 27;33(6):776-791. Epub 2018 Nov 27.

1 College of Materials Science and Metallurgy Engineering, Guizhou University, Guiyang, China.

Biodegradable polymers, because their degradation products are small molecules that do not cause immune system rejection, have been increasingly used by researchers to explore the preparation of scaffold with excellent mechanical properties, biocompatibility and biodegradability. In this study, nano-hydroxyapatite and polybutylene succinate were mixed by solution-blending to prepare a porous scaffold that could be used in the biomedical industry. Based on the viewpoint of bionics, porous scaffold with well pore structure and uniform dispersion of nano-hydroxyapatite particles was prepared using ethanol as a porogen. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218812486
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http://dx.doi.org/10.1177/0885328218812486DOI Listing
January 2019
4 Reads

A three-dimensional human skin model to evaluate the inhibition of Staphylococcus aureus by antimicrobial peptide-functionalized silver carbon nanotubes.

J Biomater Appl 2019 Feb 24;33(7):924-934. Epub 2018 Nov 24.

4 Alabama State University College of Science Mathematics and Technology, Montgomery, AL, USA.

Objective: To investigate the toxicity and antibacterial application of antimicrobial peptide-functionalized silver-coated carbon nanotubes against Staphylococcus infection using a full thickness human three-dimensional skin model.

Materials And Methods: The three-dimensional skin formation on the scaffolds was characterized by electron microscopy and investigation of several skin cell markers by real time-reverse transcriptase polymerase chain reaction. Functionalized silver-coated carbon nanotubes were prepared using carboxylated silver-coated carbon nanotubes with antimicrobial peptides such as TP359, TP226 and TP557. Read More

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http://dx.doi.org/10.1177/0885328218814984DOI Listing
February 2019
10 Reads

Mussel-inspired in situ forming adhesive hydrogels with anti-microbial and hemostatic capacities for wound healing.

J Biomater Appl 2019 Feb 22;33(7):915-923. Epub 2018 Nov 22.

1 School of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan, Shihezi, Xinjiang, China.

All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. Read More

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http://dx.doi.org/10.1177/0885328218810552DOI Listing
February 2019
16 Reads
2.197 Impact Factor

In vitro performance of a nanobiocomposite scaffold containing boron-modified bioactive glass nanoparticles for dentin regeneration.

J Biomater Appl 2019 Jan 20;33(6):834-853. Epub 2018 Nov 20.

4 Department of Engineering Sciences, Middle East Technical University, Ankara, Turkey.

Every year, many dental restoration methods are carried out in the world and most of them do not succeed. High cost of these restorations and rejection possibility of the implants are main drawbacks. For this reason, a regenerative approach for repairing the damaged dentin-pulp complex or generating a new tissue is needed. Read More

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http://dx.doi.org/10.1177/0885328218812487DOI Listing
January 2019
7 Reads

Structural and bone marrow stem cell biocompatibility studies of hydrogel synthesized via chemo-enzymatic route.

J Biomater Appl 2019 Jan 20;33(6):854-865. Epub 2018 Nov 20.

1 Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.

Natural biopolymers have many attractive medical applications; however, complications due to fibrosis caused a reduction in diffusion and dispersal of nutrients and waste products. Consequently, severe immunocompatibility problems and poor mechanical and degradation properties in synthetic polymers ensue. Hence, the present study investigates a novel hydrogel material synthesized from caprolactone, ethylene glycol, ethylenediamine, polyethylene glycol, ammonium persulfate, and tetramethylethylenediamine via chemo-enzymatic route. Read More

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http://dx.doi.org/10.1177/0885328218812490DOI Listing
January 2019
9 Reads

Osteoconductive 3D porous composite scaffold from regenerated cellulose and cuttlebone-derived hydroxyapatite.

J Biomater Appl 2019 Jan 19;33(6):876-890. Epub 2018 Nov 19.

1 Department of Polymer Chemistry and Technology, Kaunas University of Technology, Kaunas, Lithuania.

Recently, usage of marine-derived materials in biomedical field has come into prominence due to their promising characteristics such as biocompatibility, low immunogenicity and wide accessibility. Among these marine sources, cuttlebone has been used as a valuable component with its trace elemental composition in traditional medicine. Recent studies have focused on the use of cuttlebone as a bioactive agent for tissue engineering applications. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218811040
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http://dx.doi.org/10.1177/0885328218811040DOI Listing
January 2019
12 Reads

DPSCs seeded in acellular nerve grafts processed by Myroilysin improve nerve regeneration.

J Biomater Appl 2019 Jan 17;33(6):819-833. Epub 2018 Nov 17.

1 Department of Orthodontics, School of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, PR China.

Since synthetic nerve conduits do not exhibit ideal regeneration characteristics, they are generally inadequate substitutes for autologous nerve grafts in the repair of long peripheral nerve defects. To resolve this problem, in this study, a nerve regeneration acellular nerve graft (ANG) with homologous dental pulp stem cells (DPSCs) was constructed. Xenogeneic ANG was processed by Myroilysin to completely remove cells and myelin sheath, while preserving extracellular matrix (ECM) microstructure of the natural nerve. Read More

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http://dx.doi.org/10.1177/0885328218812136DOI Listing
January 2019
8 Reads

Improved corrosion resistance of commercially pure magnesium after its modification by plasma electrolytic oxidation with organic additives.

J Biomater Appl 2018 Nov;33(5):725-740

2 Centro de Investigación, Innovación y Desarrollo de Materiales CIDEMAT, Facultad de Ingeniería, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.

The optimal mechanical properties render magnesium widely used in industrial and biomedical applications. However, magnesium is highly reactive and unstable in aqueous solutions, which can be modulated to increase stability of reactive metals that include the use of alloys or by altering the surface with coatings. Plasma electrolytic oxidation is an efficient and tuneable method to apply a surface coating. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218809911
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http://dx.doi.org/10.1177/0885328218809911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247453PMC
November 2018
7 Reads

3D printing mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds for bone repair.

J Biomater Appl 2019 Jan 14;33(6):755-765. Epub 2018 Nov 14.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, P. R. China.

Drug delivery and release are a major challenge fabricating bone tissue engineering. In this study, we fabricated new sustained release hydrogel scaffolds composited of mesoporous bioactive glass, sodium alginate and gelatin by a three-dimensional printing technique. Naringin and calcitonin gene-related peptide were used as drugs to prepare drug-loaded scaffolds by direct printing or surface absorption. Read More

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http://dx.doi.org/10.1177/0885328218810269DOI Listing
January 2019
10 Reads

Evaluation of the bioactivity about anti-sca-1/basic fibroblast growth factor-urinary bladder matrix scaffold for pelvic reconstruction.

J Biomater Appl 2019 Jan 14;33(6):808-818. Epub 2018 Nov 14.

5 Department of Obstetrics and Gynecology, Southwestern Hospital, Third Military Medical University, Chongqing, China.

Introduction and hypothesis: Pelvic support structure injury is the major cause of pelvic organ prolapse. At present, polypropylene-based filler material has been suggested as a common method to treat pelvic organ prolapse. However, it cannot functionally rehabilitate the pelvic support structure. Read More

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http://dx.doi.org/10.1177/0885328218811390DOI Listing
January 2019
9 Reads

Histological and structural evaluation of growth hormone and PLGA incorporation in macroporous scaffold of α-tricalcium phosphate cement.

J Biomater Appl 2019 Jan 14;33(6):866-875. Epub 2018 Nov 14.

1 School of Health Sciences, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

An in vivo study was conducted to evaluate the effects of the incorporation of fibers of poly(lactic acid-co-glycolic acid, PLGA) and poly(isoprene) blend and recombinant human growth hormone (rhGH) in a macroporous scaffold of α-tricalcium phosphate cement (α-TCP) samples inserted into calvarial defects (8 mm in diameter) of 48 Wistar rats. The samples of α-TCP + PLGA/poly(isoprene) blend fibers were also submitted to a mechanical test of flexural strength. The animals of the different experimental groups [1] α-TCP (n = 6); [2] α-TCP + PLGA/poly(isoprene) blend fibers (n = 6); [3] α-TCP + rhGH, (n = 6) and [4] α-TCP + PLGA/poly(isoprene) blend fibers + rhGH, (n = 6) (the numbers within square brackets identify the experimental groups), after two weeks (subdivision "a") and four weeks (subdivision "b"), were euthanized and the implants removed for histological analysis. Read More

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http://dx.doi.org/10.1177/0885328218812173DOI Listing
January 2019
7 Reads

Freeze-dried chitosan-platelet-rich plasma implants improve supraspinatus tendon attachment in a transosseous rotator cuff repair model in the rabbit.

J Biomater Appl 2019 Jan 14;33(6):792-807. Epub 2018 Nov 14.

4 Ecole Polytechnique de Montreal, 2900 Boul Edouard-Montpetit, Montreal, Canada.

Rotator cuff tears result in shoulder pain, stiffness, weakness and loss of motion. After surgical repair, high failure rates have been reported based on objective imaging and it is recognized that current surgical treatments need improvement. The aim of the study was to assess whether implants composed of freeze-dried chitosan (CS) solubilized in autologous platelet-rich plasma (PRP) can improve rotator cuff repair in a rabbit model. Read More

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http://dx.doi.org/10.1177/0885328218811386DOI Listing
January 2019
19 Reads

Effect of water glass coating of tricalcium phosphate granules on in vivo bone formation.

J Biomater Appl 2018 Nov 5;33(5):662-672. Epub 2018 Nov 5.

4 Materials Science and Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, Korea.

Background: Recently, some authors introduced a water glass (WG, sodium-silicate glass; NaO·SiO·nHO) coating over tricalcium phosphate (TCP) bioceramic to modulate its resorption rate and enhance the bone cell behaviors. In this study, four different types of granular samples were prepared to evaluate the ability of new bone formation in vivo using micro-computed tomography and histology.

Methods: Four types sample groups: group A (pure HA as a negative resorption control); group B (pure TCP as a positive resorption control); group C (WG-coated TCP as an early resorption model); and group D (same as group C but heat-treated at 500°C as a delayed resorption model). Read More

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http://journals.sagepub.com/doi/10.1177/0885328218808038
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http://dx.doi.org/10.1177/0885328218808038DOI Listing
November 2018
15 Reads

Microstructure, mechanical properties, and preliminary biocompatibility evaluation of binary Ti-Zr alloys for dental application.

J Biomater Appl 2019 Jan 5;33(6):766-775. Epub 2018 Nov 5.

1 State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China.

The microstructure, mechanical properties, and in vitro biocompatibility of vacuum-sintered Ti-xZr binary alloys (x = 5, 15, 25, 35, 45 wt%) were investigated. The results indicated that α and α' phase existed in Ti-xZr alloys. The hardness of the Ti-Zr alloys increased as the contents increased and ranged from 473 HV (Ti-5Zr) to 525 HV (Ti-45Zr). Read More

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http://dx.doi.org/10.1177/0885328218811052DOI Listing
January 2019
1 Read

The controlled naringin release from TiO nanotubes to regulate osteoblast differentiation.

J Biomater Appl 2018 Nov 2;33(5):673-680. Epub 2018 Nov 2.

2 Biomedical Engineering Research Center, Medical School of Ningbo University, Ningbo, Zhejiang, China.

To design titanium (Ti)-based biomaterials with controlled drug-releasing bioactive property, TiO nanotubes with a diameter of approximately 110 nm was fabricated by electrochemical anodization. TiO nanotubes were then loaded with naringin by direct dropping and coated with chitosan layers. The surface morphologies, chemical compositions and wettability of different substrates were characterized by field emission scanning electron microscopy, atomic force microscope, X-ray photoelectron spectroscopy and contact angle measurement, respectively. Read More

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http://dx.doi.org/10.1177/0885328218809239DOI Listing
November 2018
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Enhancement of radiotherapeutic efficacy for esophageal cancer by paclitaxel-loaded red blood cell membrane nanoparticles modified by the recombinant protein anti-EGFR-iRGD.

J Biomater Appl 2018 Nov 2;33(5):707-724. Epub 2018 Nov 2.

1 The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.

Paclitaxel is widely used as a radiosensitizer for various tumors, including esophageal cancer, but its therapeutic effect remains to be improved. In this study, we constructed a novel nano-radiosensitizer, anti-EGFR-iRGD-conjugated (iE)-PRNPs, by conjugating the recombinant protein anti-epidermal growth factor receptor (EGFR)-internalizing arginine-glycine-aspartic (iRGD) to the surface of paclitaxel-loaded red blood cell membrane nanoparticles (PRNPs). The iE-PRNPs were confirmed to possess tumor-targeting, high penetrability, and sustained release properties that free paclitaxel does not possess. Read More

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http://dx.doi.org/10.1177/0885328218809019DOI Listing
November 2018
3 Reads

Improved connective integration of a degradable 3D-nano-apatite/agarose scaffold subcutaneously implanted in a rat model.

J Biomater Appl 2018 Nov 2;33(5):741-752. Epub 2018 Nov 2.

1 Departments of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá. Alcalá de Henares, Madrid, Spain. Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.

In this work, we evaluate the tissue response and tolerance to a designed 3D porous scaffold composed of nanocrystalline carbonate-hydroxyapatite and agarose as a preliminary step in bone repair and regeneration. These scaffolds were subcutaneously implanted into rats, which were sacrificed at different times. CD4+, CD8+ and ED1+ cells were evaluated as measurements of inflammatory reaction and tolerance. Read More

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http://dx.doi.org/10.1177/0885328218810084DOI Listing
November 2018
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Design and fabrication of conductive nanofibrous scaffolds for neural tissue engineering: Process modeling via response surface methodology.

J Biomater Appl 2018 Nov 2;33(5):619-629. Epub 2018 Nov 2.

1 Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.

Peripheral nervous system in contrary to central one has the potential for regeneration, but its regrowth requires proper environmental conditions and supporting growth factors. The aim of this study is to design and fabricate a conductive polyaniline/graphene nanoparticles incorporated gelatin nanofibrous scaffolds suitable for peripheral nervous system regeneration. The scaffolds were fabricated with electrospinning and the fabrication process was designed with Design-Expert software via response surface methodology. Read More

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http://dx.doi.org/10.1177/0885328218808917DOI Listing
November 2018
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Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution.

J Biomater Appl 2018 Nov 30;33(5):630-636. Epub 2018 Oct 30.

1 Department of Biomaterials, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Bridging beta-tricalcium phosphate (β-TCP) granules with dicalcium phosphate dihydrate (DCPD) creates a porous, interconnected β-TCP granular cement (GC) that is useful for reconstructing bone defects: the interconnected pores can accelerate new bone ingrowth and the set cement prevents the loss of granules from the bone defect area. However, the setting time of β-TCP GC in an acidic calcium phosphate solution is too short (<1 min) for handling in clinical applications, such as in orthopedic surgery. To address this issue, we sought to optimize the setting time of β-TCP GC using β-TCP granules and NaHSO solution, as [Formula: see text] is a known inhibitor of DCPD formation. Read More

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http://dx.doi.org/10.1177/0885328218808015DOI Listing
November 2018
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Reversible physical crosslinking strategy with optimal temperature for 3D bioprinting of human chondrocyte-laden gelatin methacryloyl bioink.

J Biomater Appl 2018 Nov 25;33(5):609-618. Epub 2018 Oct 25.

1 Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China.

Gelatin methacryloyl is a promising material in tissue engineering and has been widely studied in three-dimensional bioprinting. Although gelatin methacryloyl possesses excellent biocompatibility and tunable mechanical properties, its poor printability/processability has hindered its further applications. In this study, we report a reversible physical crosslinking strategy for precise deposition of human chondrocyte-laden gelatin methacryloyl bioink at low concentration without any sacrificial material by using extrusive three-dimensional bioprinting. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218805864
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http://dx.doi.org/10.1177/0885328218805864DOI Listing
November 2018
11 Reads
2.200 Impact Factor

Poly(ethylene glycol) induces cell toxicity in melanoma cells by producing a hyperosmotic extracellular medium.

J Biomater Appl 2018 Nov 25;33(5):693-706. Epub 2018 Oct 25.

McMaster University, Hamilton, Ontario, Canada.

Poly(ethylene glycol) is a polymer that is widely used as a biomaterial and has been approved in a host of applications. While generally viewed as inert, recent studies with poly(ethylene glycol) suggest that it may have some effects on cells and tissues, making it potentially attractive as a therapeutic agent. In this study, the effect of poly(ethylene glycol) on the cell viability, membrane transport and apoptotic markers of metastatic melanoma cells was examined. Read More

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http://journals.sagepub.com/doi/10.1177/0885328218807675
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http://dx.doi.org/10.1177/0885328218807675DOI Listing
November 2018
15 Reads

Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels.

J Biomater Appl 2018 Nov 25;33(5):681-692. Epub 2018 Oct 25.

1 Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical translation of hydrogel-based therapies has been limited due to difficulties injecting them through catheters. We have engineered a novel catheter, Advanced Materials Catheter (AMCath), that overcomes translational hurdles associated with delivering fast-gelling covalently cross-linked hyaluronic acid hydrogels to the myocardium. Read More

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http://dx.doi.org/10.1177/0885328218805878DOI Listing
November 2018
2 Reads