1,458 results match your criteria Journal of biological rhythms[Journal]


Differential Recovery Speed of Activity and Metabolic Rhythms in Rats After an Experimental Protocol of Shift-Work.

J Biol Rhythms 2019 Feb 15:748730419828534. Epub 2019 Feb 15.

Departamento de Fisiología, Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.

The circadian system drives the temporal organization of body physiology in relation to the changing daily environment. Shift-work (SW) disrupts this temporal order and is associated with the loss of homeostasis and metabolic syndrome. In a rodent model of SW based on forced activity in the rest phase for 4 weeks, we describe the occurrence of circadian desynchrony, as well as metabolic and liver dysfunction. Read More

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http://dx.doi.org/10.1177/0748730419828534DOI Listing
February 2019

CikA Modulates the Effect of KaiA on the Period of the Circadian Oscillation in KaiC Phosphorylation.

J Biol Rhythms 2019 Feb 13:748730419828068. Epub 2019 Feb 13.

Department of Chemistry and Environmental Science.

Cyanobacteria contain a circadian oscillator that can be reconstituted in vitro. In the reconstituted circadian oscillator, the phosphorylation state of KaiC oscillates with a circadian period, spending about 12 h in the phosphorylation phase and another 12 h in the dephosphorylation phase. Although some entrainment studies have been performed using the reconstituted oscillator, they were insufficient to fully explain entrainment mechanisms of the cyanobacterial circadian clock due to the lack of input pathway components in the in vitro oscillator reaction mixture. Read More

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http://dx.doi.org/10.1177/0748730419828068DOI Listing
February 2019

Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital Nurses.

J Biol Rhythms 2019 Feb 4:748730419826694. Epub 2019 Feb 4.

Department of Psychiatry and Behavioral Neurobiology.

Circadian misalignment between sleep and behavioral/feeding rhythms is thought to lead to various health impairments in shift workers. Therefore, we investigated how shift work leads to genome-wide circadian dysregulation in hospital nurses. Female nurses from the University of Alabama at Birmingham (UAB) Hospital working night shift ( n = 9; 29. Read More

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http://dx.doi.org/10.1177/0748730419826694DOI Listing
February 2019

Effect of Night Time Eating on Postprandial Triglyceride Metabolism in Healthy Adults: A Systematic Literature Review.

J Biol Rhythms 2019 Jan 25:748730418824214. Epub 2019 Jan 25.

Department of Nutrition, Dietetics and Food, Monash University, VIC Australia.

Eating at night time, as is frequent in shift workers, may contribute to increased cardiovascular disease (CVD) risk through a disruption in usual lipid metabolism, resulting in repeated and sustained hyperlipidemia at night. This systematic review aimed to investigate the impact of eating a meal at night compared with the same meal eaten during the day on postprandial lipemia. Six databases were searched: CINAHL Plus, Cochrane Library, EMBASE, Ovid MEDLINE, Informit, and SCOPUS. Read More

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http://dx.doi.org/10.1177/0748730418824214DOI Listing
January 2019

Development-Dependent Changes in the NR2 Subtype of the N-Methyl-D-Aspartate Receptor in the Suprachiasmatic Nucleus of the Rat.

J Biol Rhythms 2019 Feb 17;34(1):39-50. Epub 2019 Jan 17.

Centro Universitario de Investigaciones Biomédicas "CUIB", Universidad de Colima, Colima, Col, Mexico.

The suprachiasmatic nucleus (SCN) is the main brain clock that regulates circadian rhythms in mammals. The SCN synchronizes to the LD cycle through the retinohypothalamic tract (RHT), which projects to ventral SCN neurons via glutamatergic synapses. Released glutamate activates N-methyl-D-aspartate (NMDA) receptors, which play a critical role in the activation of signaling cascades to enable phase shifts. Read More

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http://dx.doi.org/10.1177/0748730418824198DOI Listing
February 2019
1 Read

The Phase-Shifting Effect of Bright Light Exposure on Circadian Rhythmicity in the Human Transcriptome.

J Biol Rhythms 2019 Jan 8:748730418821776. Epub 2019 Jan 8.

Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.

Light is a potent synchronizer of the central circadian clock; however, the effect of light exposure on peripheral gene expression is largely unknown. The objective of this study was to explore the effect of bright light exposure on genome-wide peripheral gene expression levels during a 4-day simulated night shift protocol in which the habitual sleep period is delayed by 10 h. Eleven healthy participants (mean age, 24 years; range, 18-30; 10 men/1 woman) were studied under controlled laboratory conditions. Read More

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http://journals.sagepub.com/doi/10.1177/0748730418821776
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http://dx.doi.org/10.1177/0748730418821776DOI Listing
January 2019
1 Read
2.774 Impact Factor

Novel Light/Dark Regimens with Minimum Light Promote Circadian Disruption: Simulations with a Model Oscillator.

J Biol Rhythms 2018 Dec 31:748730418820727. Epub 2018 Dec 31.

Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil.

Artificial lab manipulation of LD cycles has enabled simulations of the disruptive conditions found in modern human societies, such as jet-lag, night-work and light at night. New techniques using animal models have been developed, and these can greatly improve our understanding of circadian disruption. Some of these techniques, such as in vivo bioluminescence assays, require minimum external light. Read More

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http://dx.doi.org/10.1177/0748730418820727DOI Listing
December 2018

Diurnality, Type 2 Diabetes, and Depressive-Like Behavior.

J Biol Rhythms 2019 Feb 25;34(1):69-83. Epub 2018 Dec 25.

School of Zoology, Tel-Aviv University, Tel Aviv, Ramat Aviv, Israel.

Although type 2 diabetes (T2DM) and depression are associated with disturbances in circadian rhythms, most studies of these diseases use nocturnal mice and rats while modeling diurnal humans. We suggest that the development of T2DM and depression are related to changes that accompany the switch from the mammalian ancestral nocturnal activity to the current diurnal one. We show that diurnal sand rats ( Psammomys obesus) held outdoors in laboratory cages (where they are exposed to natural environmental conditions) and fed a standard rodent diet do not develop T2DM in contrast to animals held indoors (where the only cycling environmental condition is light) fed the same diet. Read More

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http://journals.sagepub.com/doi/10.1177/0748730418819373
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http://dx.doi.org/10.1177/0748730418819373DOI Listing
February 2019
1 Read

Phase Shifts to a Moderate Intensity Light Exposure in Older Adults: A Preliminary Report.

J Biol Rhythms 2018 Dec 17:748730418818655. Epub 2018 Dec 17.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

Age-related disrupted sleep has been associated with modifications in the timing of endogenous circadian rhythms. There are studies suggesting a decreased sensitivity of the aging circadian pacemaker to light. In this study, we aimed to test whether a moderate illuminance light stimulus would produce significant phase shifts in older adults, and whether those would fall in a range consistent with the illuminance response curve (IRC) we previously reported in older adults. Read More

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http://dx.doi.org/10.1177/0748730418818655DOI Listing
December 2018

LimoRhyde: A Flexible Approach for Differential Analysis of Rhythmic Transcriptome Data.

J Biol Rhythms 2018 Nov 25:748730418813785. Epub 2018 Nov 25.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Unraveling the effects of genetic or environmental perturbations on biological rhythms requires detecting changes in rhythmicity across multiple conditions. Although methods to detect rhythmicity in genome-scale data are well established, methods to detect changes in rhythmicity or changes in average expression between experimental conditions are often ad hoc and statistically unreliable. Here we present LimoRhyde (linear models for rhythmicity, design), a flexible approach for analyzing transcriptome data from circadian systems. Read More

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http://dx.doi.org/10.1177/0748730418813785DOI Listing
November 2018
1 Read

Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice.

J Biol Rhythms 2018 Dec 15;33(6):662-670. Epub 2018 Oct 15.

Department of Basic Medical Sciences, University of Arizona College of Medicine - Phoenix, Phoenix, Arizona.

Up to 80% of people meeting DSM-IV definitions for schizophrenia will exhibit difficulties with sleep, along with a breakdown in circadian entrainment and rhythmicity. The changes to the sleep and circadian systems in this population are thought to be interdependent, as evidenced by the frequent use of the combined term "sleep and circadian rhythm disruption" or "SCRD" to describe their occurrence. To understand links between sleep and circadian problems in the schizophrenia population, we analyzed the duration and rhythmicity of sleep behavior in mice lacking function of the immediate early gene early growth response 3 ( Egr3). Read More

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http://dx.doi.org/10.1177/0748730418803802DOI Listing
December 2018
1 Read

A Novel Diabetic Mouse Model for Real-Time Monitoring of Clock Gene Oscillation and Blood Pressure Circadian Rhythm.

J Biol Rhythms 2018 Oct 2:748730418803719. Epub 2018 Oct 2.

Department of Physiology, University of Kentucky, Lexington, Kentucky.

Diabetic patients have an increased prevalence of blood pressure (BP) circadian rhythm disruption, which is associated with an increased risk of target organ damage and detrimental cardiovascular events. Limited information is available regarding the role of clock genes in the disruption of BP circadian rhythm in diabetes due to the lack of a diabetic animal model that allows real-time monitoring of clock gene oscillation. Here, we generated a novel diabetic db/db-mPer2 mouse model by crossing type 2 diabetic db/db mice with mPer2 knock-in mice. Read More

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http://journals.sagepub.com/doi/10.1177/0748730418803719
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http://dx.doi.org/10.1177/0748730418803719DOI Listing
October 2018
26 Reads
2.774 Impact Factor

Melatonin Administration Methods for Research in Mammals and Birds.

J Biol Rhythms 2018 Dec 24;33(6):567-588. Epub 2018 Sep 24.

University of California, Berkeley, CA, USA.

Endocrine research in animals often entails exogenous hormone administration. Special issues arise when developing administration protocols for hormones with circadian and seasonal periodicity. This article reviews various methods for the exogenous administration of hormones with such periodicities by focusing on melatonin. Read More

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http://journals.sagepub.com/doi/10.1177/0748730418795802
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http://dx.doi.org/10.1177/0748730418795802DOI Listing
December 2018
5 Reads

Closely Related Fruit Fly Species Living at Different Latitudes Diverge in Their Circadian Clock Anatomy and Rhythmic Behavior.

J Biol Rhythms 2018 Dec 11;33(6):602-613. Epub 2018 Sep 11.

Neurobiology and Genetics, Biocenter, University of Würzburg, Würzburg, Germany.

Recently, we reported differences in the expression pattern of the blue light-sensitive flavoprotein cryptochrome (CRY) and the neuropeptide pigment-dispersing factor (PDF) in the neuronal clock network of high-latitude Drosophila species, belonging to the Drosophila subgenus ( virilis-repleta radiation), compared with cosmopolitan D. melanogaster flies, belonging to the Sophophora subgenus. Alterations in rhythmic patterns of activity due to these differences might have adaptive significance for colonizing high-latitude habitats and, hence, adjusting to long photoperiods. Read More

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http://dx.doi.org/10.1177/0748730418798096DOI Listing
December 2018

Investigation of Dose-Response Relationships for Effects of White Light Exposure on Correlates of Alertness and Executive Control during Regular Daytime Working Hours.

J Biol Rhythms 2018 Dec 10;33(6):649-661. Epub 2018 Sep 10.

Human-Technology Interaction, School of Innovation Sciences, Eindhoven University of Technology, Eindhoven, the Netherlands.

To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye level) to investigate the dose-dependent relationship between light and correlates of alertness and executive control during regular working hours in the morning and afternoon. Each participant was exposed to a single-intensity light level for 1 h after a 30-min baseline phase (100 lux at the eye) in the morning and afternoon (on separate days) during their daily routine. Read More

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http://dx.doi.org/10.1177/0748730418796438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236584PMC
December 2018
12 Reads

White Light During Daytime Does Not Improve Alertness in Well-rested Individuals.

J Biol Rhythms 2018 Dec 7;33(6):637-648. Epub 2018 Sep 7.

University of Groningen, Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, Groningen, the Netherlands.

Broad-spectrum light applied during the night has been shown to affect alertness in a dose-dependent manner. The goal of this experiment was to investigate whether a similar relationship could be established for light exposure during daytime. Fifty healthy participants were subjected to a paradigm (0730-1730 h) in which they were intermittently exposed to 1. Read More

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http://dx.doi.org/10.1177/0748730418796036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236585PMC
December 2018

Light, Alertness, and Alerting Effects of White Light: A Literature Overview.

J Biol Rhythms 2018 Dec 7;33(6):589-601. Epub 2018 Sep 7.

Human-Technology Interaction, School of Innovation Sciences, Eindhoven University of Technology, Eindhoven, the Netherlands.

Light is known to elicit non-image-forming responses, such as effects on alertness. This has been reported especially during light exposure at night. Nighttime results might not be translatable to the day. Read More

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http://dx.doi.org/10.1177/0748730418796443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236641PMC
December 2018

Implicating a Temperature-Dependent Clock in the Regulation of Torpor Bout Duration in Classic Hibernation.

J Biol Rhythms 2018 Dec 7;33(6):626-636. Epub 2018 Sep 7.

Institute for Cellular and Integrative Neurosciences, UPR 3212, Centre National de la Recherche Scientifique (CNRS) and University of Strasbourg, Strasbourg, France.

Syrian hamsters may present 2 types of torpor when exposed to ambient temperatures in the winter season, from 8°C to 22°C (short photoperiod). The first is daily torpor, which is controlled by the master circadian clock of the body, located in the SCN. In this paper, we show that daily torpor bout duration is unchanged over the 8°C to 22°C temperature range, as predicted from the thermal compensation of circadian clocks. Read More

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http://dx.doi.org/10.1177/0748730418797820DOI Listing
December 2018

Two Coupled Circadian Oscillators Are Involved in Nonphotic Acceleration of Reentrainment to Shifted Light Cycles in Mice.

J Biol Rhythms 2018 Dec 4;33(6):614-625. Epub 2018 Sep 4.

Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

The onset and offset of an activity band in the circadian behavioral rhythm are known to differentially reentrain to shifted light-dark cycles (LD). Differential reentrainment could be explained by different light responsivities of circadian oscillators underlying these phase-markers. In contrast, reentrainment is accelerated by exposure to nonphotic time cues such as timed wheel-running. Read More

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http://dx.doi.org/10.1177/0748730418796300DOI Listing
December 2018

The Phosphorylation of CREB at Serine 133 Is a Key Event for Circadian Clock Timing and Entrainment in the Suprachiasmatic Nucleus.

J Biol Rhythms 2018 Oct 3;33(5):497-514. Epub 2018 Sep 3.

Department of Neuroscience, Ohio State University, Columbus, OH.

Within the suprachiasmatic nucleus (SCN)-the locus of the master circadian clock- transcriptional regulation via the CREB/CRE pathway is implicated in the functioning of the molecular clock timing process, and is a key conduit through which photic input entrains the oscillator. One event driving CRE-mediated transcription is the phosphorylation of CREB at serine 133 (Ser). Indeed, numerous reporter gene assays have shown that an alanine point mutation in Ser reduces CREB-mediated transcription. Read More

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http://dx.doi.org/10.1177/0748730418791713DOI Listing
October 2018
1 Read

Evidence for a Coupled Oscillator Model of Endocrine Ultradian Rhythms.

J Biol Rhythms 2018 Oct 22;33(5):475-496. Epub 2018 Aug 22.

The Helen Wills Neuroscience Institute, University of California, Berkeley, California.

Whereas long-period temporal structures in endocrine dynamics have been well studied, endocrine rhythms on the scale of hours are relatively unexplored. The study of these ultradian rhythms (URs) has remained nascent, in part, because a theoretical framework unifying ultradian patterns across systems has not been established. The present overview proposes a conceptual coupled oscillator network model of URs in which oscillating hormonal outputs, or nodes, are connected by edges representing the strength of node-node coupling. Read More

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http://dx.doi.org/10.1177/0748730418791423DOI Listing
October 2018

Bootstrapping and Empirical Bayes Methods Improve Rhythm Detection in Sparsely Sampled Data.

J Biol Rhythms 2018 Aug;33(4):339-349

Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois.

There is much interest in using genome-wide expression time series to identify circadian genes. However, the cost and effort of such measurements often limit data collection. Consequently, it is difficult to assess the experimental uncertainty in the measurements and, in turn, to detect periodic patterns with statistical confidence. Read More

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http://dx.doi.org/10.1177/0748730418789536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347739PMC
August 2018
1 Read

Model-based Inference of a Directed Network of Circadian Neurons.

J Biol Rhythms 2018 Oct 7;33(5):515-522. Epub 2018 Aug 7.

University of California, Santa Barbara, California.

The suprachiasmatic nucleus (SCN) is the master clock of the brain. It is a network of neurons that behave like biological oscillators, capable of synchronizing and maintaining daily rhythms. The detailed structure of this network is still unknown, and the role that the connectivity pattern plays in the network's ability to generate robust oscillations has yet to be fully elucidated. Read More

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http://dx.doi.org/10.1177/0748730418790402DOI Listing
October 2018

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease.

J Biol Rhythms 2018 Oct 7;33(5):535-554. Epub 2018 Aug 7.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.

Huntington's disease (HD) patients suffer from progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances in sleep-wake cycles are common among HD patients with reports of delayed sleep onset, frequent bedtime awakenings, and excessive fatigue. The BACHD mouse model exhibits many HD core symptoms including circadian dysfunction. Read More

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http://dx.doi.org/10.1177/0748730418790401DOI Listing
October 2018
2.774 Impact Factor

Changes in Accident & Emergency Visits and Return Visits in Relation to the Enforcement of Daylight Saving Time and Photoperiod.

J Biol Rhythms 2018 Oct 30;33(5):555-564. Epub 2018 Jul 30.

Department of Medicine, University of Padova, Padova, Italy.

Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome of Accident & Emergency (A&E) visits/return visits over the DST months. The study included 366,527 visits and 84,380 return visits to the A&E of Padova hospital (Northern Italy) over 3 periods between the years 2007 and 2016: period 1 (2 weeks prior to DST to 19 weeks after), period 2 (2 weeks prior to the return to "winter time" to 4 weeks after), and period 3 (5 consecutive non-DST weeks). Read More

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http://dx.doi.org/10.1177/0748730418791097DOI Listing
October 2018
2 Reads

Circadian Health and Light: A Report on the National Heart, Lung, and Blood Institute's Workshop.

J Biol Rhythms 2018 Oct 23;33(5):451-457. Epub 2018 Jul 23.

Center for Circadian and Sleep Medicine, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little information regarding the quantity and characteristics of light exposure that people receive. To address this, the National Center on Sleep Disorders Research, in the Division of Lung Diseases, National Heart, Lung, and Blood Institute, held a workshop in August 2016 on circadian health and light. Workshop participants discussed scientific research advances on the effects of light on human physiology, identified remaining knowledge gaps in these research areas, and articulated opportunities to use appropriate lighting to protect and improve circadian-dependent health. Read More

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http://dx.doi.org/10.1177/0748730418789506DOI Listing
October 2018
12 Reads

Caffeine Delays Light-entrained Activity and Potentiates Circadian Photic Phase-resetting in Mice.

J Biol Rhythms 2018 Oct 23;33(5):523-534. Epub 2018 Jul 23.

Indiana University of Pennsylvania, Indiana, Pennsylvania.

Caffeine is widely used to reduce sedation and increase alertness. However, long-term caffeine use may disrupt circadian (daily, 24-h) rhythms and thereby negatively affect health. Here, we examined the effect of caffeine on photic regulation of circadian activity rhythms in mice. Read More

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http://dx.doi.org/10.1177/0748730418789236DOI Listing
October 2018
2 Reads

The Mysterious Food-Entrainable Oscillator: Insights from Mutant and Engineered Mouse Models.

J Biol Rhythms 2018 Oct 23;33(5):458-474. Epub 2018 Jul 23.

Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas.

The food-entrainable oscillator (FEO) is a mysterious circadian clock because its anatomical location(s) and molecular timekeeping mechanism are unknown. Food anticipatory activity (FAA), which is defined as the output of the FEO, emerges during temporally restricted feeding. FAA disappears immediately during ad libitum feeding and reappears during subsequent fasting. Read More

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http://dx.doi.org/10.1177/0748730418789043DOI Listing
October 2018

Spectral Tuning of White Light Allows for Strong Reduction in Melatonin Suppression without Changing Illumination Level or Color Temperature.

J Biol Rhythms 2018 Aug 9;33(4):420-431. Epub 2018 Jul 9.

Philips Lighting Research, Department Lighting Applications, Eindhoven, The Netherlands.

Studies with monochromatic light stimuli have shown that the action spectrum for melatonin suppression exhibits its highest sensitivity at short wavelengths, around 460 to 480 nm. Other studies have demonstrated that filtering out the short wavelengths from white light reduces melatonin suppression. However, this filtering of short wavelengths was generally confounded with reduced light intensity and/or changes in color temperature. Read More

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http://dx.doi.org/10.1177/0748730418784041DOI Listing
August 2018
3 Reads

Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus.

J Biol Rhythms 2018 Aug 5;33(4):376-387. Epub 2018 Jul 5.

Neuroscience Institute and Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA.

Over 90% of neurons within the suprachiasmatic nucleus (SCN) express γ-aminobutyric acid (GABA). Although GABA is primarily an inhibitory neurotransmitter, in vitro studies suggest that the activation of GABA receptors (GABAR) elicits excitation in the adult SCN. The ratio of excitatory to inhibitory responses to GABA depends on the balance of chloride influx by Na-K-Cl cotransporter 1 (NKCC1) and chloride efflux by K-Cl cotransporters (KCCs). Read More

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http://dx.doi.org/10.1177/0748730418782820DOI Listing
August 2018
2 Reads

Musicians' Natural Frequencies of Performance Display Optimal Temporal Stability.

J Biol Rhythms 2018 Aug 25;33(4):432-440. Epub 2018 Jun 25.

Department of Psychology, McGill University, Montreal, QC, Canada.

Many human action sequences, such as speaking and performing music, are inherently rhythmic: Sequence events are produced at quasi-regular temporal intervals. A wide range of interindividual variation has been noted in spontaneous production rates of these rhythmic action sequences. Dynamical theories of motor coordination suggest that individuals spontaneously produce rhythmic sequences at a natural frequency characterized by minimal energy expenditure and maximal temporal stability, relative to other frequencies. Read More

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http://dx.doi.org/10.1177/0748730418783651DOI Listing

Aging Alters Circadian Rhythms in the Mouse Eye.

J Biol Rhythms 2018 Aug 25;33(4):441-445. Epub 2018 Jun 25.

Department of Pharmacology & Toxicology, Morehouse School of Medicine, Atlanta, Georgia.

The eye contains a circadian system that acts independently from the master circadian clock located in the brain. This circadian system regulates important physiological functions within the eye. Emerging experimental evidence also indicates that disruption of the ocular circadian clock, or its outputs, negatively affects the overall health of the eye. Read More

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http://dx.doi.org/10.1177/0748730418783648DOI Listing

Rapid Response and Slow Recovery of the H3K4me3 Epigenomic Marker in the Liver after Light-mediated Phase Advances of the Circadian Clock.

J Biol Rhythms 2018 Aug 11;33(4):363-375. Epub 2018 Jun 11.

Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon.

Mammalian tissues display circadian rhythms in transcription, translation, and histone modifications. Here we asked how an advance of the light-dark cycle alters daily rhythms in the liver epigenome at the H3K4me3 (trimethylation of lysine 4 on histone 3) modification, which is found at active and poised gene promoters. H3K4me3 levels were first measured at 4 time points (zeitgeber time [ZT] 3, 8, 15, and 20) during a normal 12L:12D light-dark cycle. Read More

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http://dx.doi.org/10.1177/0748730418779958DOI Listing
August 2018
19 Reads

Seasonal Changes in Endocannabinoid Concentrations between Active and Hibernating Marmots (Marmota flaviventris).

J Biol Rhythms 2018 Aug 4;33(4):388-401. Epub 2018 Jun 4.

2. University of California, Riverside, California.

Hibernation is a naturally occurring model for studying diseases such as obesity and osteoporosis. Hibernators, marmots (Marmota flaviventris) among them, are able to nearly double their body mass by increasing fat stores prior to hibernation without the negative consequences of obesity. They are also physically inactive for extended periods of time without experiencing negative effects on the skeleton. Read More

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http://dx.doi.org/10.1177/0748730418777660DOI Listing
August 2018
5 Reads

Regulation of Pol II Pausing Is Involved in Daily Gene Transcription in the Mouse Liver.

J Biol Rhythms 2018 Aug 30;33(4):350-362. Epub 2018 May 30.

1. These authors contributed equally to this work.

The circadian clock orchestrates gene expression rhythms. Regulation at the level of gene transcription is essential for molecular and cellular rhythms. Pol II pause release is a critical step of transcription regulation. Read More

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http://dx.doi.org/10.1177/0748730418779526DOI Listing
August 2018
1 Read

Obesity Disrupts Rhythmic Clock Gene Expression in Maternal Adipose Tissue during Rat Pregnancy.

J Biol Rhythms 2018 Jun;33(3):289-301

School of Human Sciences, The University of Western Australia, Perth, Western Australia, Australia.

Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock also undergoes major change as part of the maternal metabolic adaptation to pregnancy, but whether this is affected by maternal obesity is unknown. Read More

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http://dx.doi.org/10.1177/0748730418772499DOI Listing
June 2018
1 Read

Effects of Light and Temperature on Daily Activity and Clock Gene Expression in Two Mosquito Disease Vectors.

J Biol Rhythms 2018 Jun;33(3):272-288

Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.

Most organisms feature an endogenous circadian clock capable of synchronization with their environment. The most well-known synchronizing agents are light and temperature. The circadian clock of mosquitoes, vectors of many pathogens, drives important behaviors related to vectoral capacity, including oviposition, host seeking, and hematophagy. Read More

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http://dx.doi.org/10.1177/0748730418772175DOI Listing

Geographical Origin, Delayed Implantation, and Induced Ovulation Explain Reproductive Seasonality in the Carnivora.

J Biol Rhythms 2018 Aug 7;33(4):402-419. Epub 2018 May 7.

Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Patterns of reproductive seasonality in the Carnivora are difficult to study comparatively, due to limited numbers of species for which information is available. Long-term databases of captive populations could overcome this difficulty. We apply a categorical description and a quantitative high-resolution measure (birth peak breadth, the number of days in which 80% of all births occur) based on daily observations in captivity to characterize the degree of reproductive seasonality in the Carnivora for 114 species with on average 1357 births per species. Read More

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http://dx.doi.org/10.1177/0748730418773620DOI Listing
August 2018
8 Reads

Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre.

J Biol Rhythms 2018 Apr;33(2):179-191

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts.

Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the roles of circadian-relevant genes requires manipulation of their expression in a tissue-specific manner, ideally including manipulation with high efficiency within the suprachiasmatic nuclei (SCN). To date, conditional manipulation of genes within the SCN has been difficult. Read More

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http://dx.doi.org/10.1177/0748730418757006DOI Listing
April 2018
4 Reads

Regulation of the Neuroligin-1 Gene by Clock Transcription Factors.

J Biol Rhythms 2018 Apr;33(2):166-178

Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.

NEUROLIGIN-1 (NLGN1) is a postsynaptic adhesion molecule involved in the regulation of glutamatergic transmission. It has been associated with several features of sleep and psychiatric disorders. Our previous work suggested that transcription of the Nlgn1 gene could be regulated by the transcription factors CLOCK and BMAL1 because they bind to the Nlgn1 gene promoter in vivo. Read More

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http://dx.doi.org/10.1177/0748730418761236DOI Listing
April 2018
2 Reads

Serge Daan.

J Biol Rhythms 2018 Apr;33(2):111-116

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http://dx.doi.org/10.1177/0748730418768594DOI Listing
April 2018
2 Reads

Prediction of Cognitive Performance and Subjective Sleepiness Using a Model of Arousal Dynamics.

J Biol Rhythms 2018 Apr;33(2):203-218

School of Physics, University of Sydney, Sydney, Australia.

A model of arousal dynamics is applied to predict objective performance and subjective sleepiness measures, including lapses and reaction time on a visual Performance Vigilance Test (vPVT), performance on a mathematical addition task (ADD), and the Karolinska Sleepiness Scale (KSS). The arousal dynamics model is comprised of a physiologically based flip-flop switch between the wake- and sleep-active neuronal populations and a dynamic circadian oscillator, thus allowing prediction of sleep propensity. Published group-level experimental constant routine (CR) and forced desynchrony (FD) data are used to calibrate the model to predict performance and sleepiness. Read More

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http://dx.doi.org/10.1177/0748730418758454DOI Listing
April 2018
3 Reads

Circadian Regulation of Mitochondrial Dynamics in Retinal Photoreceptors.

J Biol Rhythms 2018 Apr;33(2):151-165

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas.

Energy expenditure and metabolism in the vertebrate retina are under circadian control, as we previously reported that the overall retinal ATP content and various signaling molecules related to metabolism display daily or circadian rhythms. Changes in the fission and fusion process of mitochondria, the major organelles producing ATP, in retinal photoreceptors are largely dependent on light exposure, but whether mitochondrial dynamics in photoreceptors and retinal neurons are under circadian control is not clear. Herein, we investigated the possible roles of circadian oscillators in regulating mitochondrial dynamics, mitophagy, and redox states in the chicken retina and mammalian photoreceptors. Read More

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http://dx.doi.org/10.1177/0748730418762152DOI Listing
April 2018
21 Reads

A Clockwork Wikipedia: From a Broad Perspective to a Case Study.

J Biol Rhythms 2018 Jun 17;33(3):233-244. Epub 2018 Apr 17.

Weizmann Institute of Science, Rehovot, Israel.

While research has shown that scientists use Wikipedia and that scientific content on Wikipedia ramifies back into scientific literature, many questions remain on how the two sides interact and through what paradigm this dynamic may be best understood. Using the circadian clock field as a case study, we discuss this scientific field's representation on Wikipedia. We traced the changes made to the articles for "Circadian clock" and "Circadian rhythm" and reviewed the debates that informed them over a span of a decade, using Wikipedia's native and third-party tools. Read More

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http://dx.doi.org/10.1177/0748730418768120DOI Listing
June 2018
1 Read

Tau-independent Phase Analysis: A Novel Method for Accurately Determining Phase Shifts.

J Biol Rhythms 2018 Jun 11;33(3):223-232. Epub 2018 Apr 11.

Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee.

Estimations of period and phase are essential in circadian biology. While many techniques exist for estimating period, comparatively few methods are available for estimating phase. Current approaches to analyzing phase often vary between studies and are sensitive to coincident changes in period and the stage of the circadian cycle at which the stimulus occurs. Read More

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http://dx.doi.org/10.1177/0748730418768116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956570PMC
June 2018
1 Read

Melatonin-independent Photoperiodic Entrainment of the Circannual TSH Rhythm in the Pars Tuberalis of the European Hamster.

J Biol Rhythms 2018 Jun 4;33(3):302-317. Epub 2018 Apr 4.

Department of Neurobiology of Rhythms, Institute for Cellular and Integrative Neuroscience, University of Strasbourg, Strasbourg, France.

Adaptation of biological rhythms to a seasonal environment in circannual mammals is achieved via the synchronization of intrinsic circannual rhythms to the external year by photoperiod. In mammals, the photoperiodic information is integrated to seasonal physiology via the pineal hormone melatonin regulation of pars tuberalis (PT) TSHβ expression and its downstream control of hypothalamic dio2 gene expression. In the circannual European hamster, however, photoperiodic entrainment of the circannual clock is possible in pinealectomized animals. Read More

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http://dx.doi.org/10.1177/0748730418766601DOI Listing
June 2018
2 Reads

Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders.

J Biol Rhythms 2018 Jun 3;33(3):318-336. Epub 2018 Apr 3.

Colgate University, Hamilton, New York.

Anxiety and other mood disorders, such as major depressive disorder (MDD) and seasonal affective disorder (SAD), affect nearly one-fifth of the global population and disproportionately affect young adults. Individuals affected by mood disorders are frequently plagued by sleep and circadian problems, and recent genetic studies provide ample support for the association of circadian and sleep syndromes with depression and anxiety. Mathematical modeling has been crucial in understanding some of the essential features of the mammalian circadian clock and is now a vital tool for dissecting how circadian genes regulate the molecular mechanisms that influence mood. Read More

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http://dx.doi.org/10.1177/0748730418764540DOI Listing
June 2018
1 Read

The Circadian Clock of the Ant Camponotus floridanus Is Localized in Dorsal and Lateral Neurons of the Brain.

J Biol Rhythms 2018 Jun 28;33(3):255-271. Epub 2018 Mar 28.

Neurobiology and Genetics, Biocenter, University of Würzburg, Würzburg, Germany.

The circadian clock of social insects has become a focal point of interest for research, as social insects show complex forms of timed behavior and organization within their colonies. These behaviors include brood care, nest maintenance, foraging, swarming, defense, and many other tasks, of which several require social synchronization and accurate timing. Ants of the genus Camponotus have been shown to display a variety of daily timed behaviors such as the emergence of males from the nest, foraging, and relocation of brood. Read More

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http://dx.doi.org/10.1177/0748730418764738DOI Listing
June 2018
2 Reads

Circadian Rhythms and Reproductive Phenology Covary in a Natural Plant Population.

J Biol Rhythms 2018 Jun 28;33(3):245-254. Epub 2018 Mar 28.

Department of Botany, University of Wyoming, Laramie, Wyoming.

The circadian clock is a molecular timekeeper that matches endogenous rhythms in diverse traits with 24-h cycles in the external environment. Although a lack of clock resonance to the environment is detrimental to performance, clock phenotypes in wild populations nevertheless deviate substantially from the predicted optimal cycle length of 24 h, and significant genetic variation exists for circadian parameters. Here, we describe covariation between 2 traits considered to reflect adaptation to different aspects of temporal environmental heterogeneity, circadian rhythms (adaptation to daily environmental cycles) and flowering time (adaptation to seasonal cycles), in a Rocky Mountain population of the mustard Boechera stricta, a North American relative of Arabidopsis thaliana. Read More

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http://dx.doi.org/10.1177/0748730418764525DOI Listing
June 2018
1 Read

Daily Profiles of Light Exposure and Evening Use of Light-emitting Devices in Young Adults Complaining of a Delayed Sleep Schedule.

J Biol Rhythms 2018 Apr 20;33(2):192-202. Epub 2018 Feb 20.

Center for Advanced Research in Sleep Medicine, Sacre-Coeur Hospital of Montreal, Montreal, QC, Canada.

A number of factors can contribute to a delayed sleep schedule. An important factor could be a daily profile of light exposure favoring a later circadian phase. This study aimed to compare light exposure between 14 young adults complaining of a delayed sleep schedule and 14 matched controls and to identify possible associations between habitual light exposure and circadian phase. Read More

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http://dx.doi.org/10.1177/0748730418757007DOI Listing
April 2018
3 Reads