2,138 results match your criteria Journal of bioenergetics and biomembranes[Journal]


Effect of hypothermia on the functional activity of liver mitochondria of grass snake (Natrix natrix): inhibition of succinate-fueled respiration and K transport, ROS-induced activation of mitochondrial permeability transition.

J Bioenerg Biomembr 2019 Apr 13. Epub 2019 Apr 13.

Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.

The article considers the comparative analysis of the functional activity of mitochondria isolated from the liver of grass snakes, Natrix natrix (Linnaeus, 1758) that were kept at different temperatures (23-26 °C and 4-5 °C). It was found that liver mitochondria of hypothermia-exposed grass snakes are characterized by weak coupling of oxidative phosphorylation as compared to mitochondria of active animals which is caused by inhibition of succinate-fuelled respiration in ADP-stimulated state, as well as by activation of basal non-phosphorylating rate. Inhibition of mitochondrial respiration in hibernating animals is associated with a decrease in the activity of the respiratory chain complexes of organelles. Read More

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http://dx.doi.org/10.1007/s10863-019-09796-6DOI Listing

Preconditioning the rat heart with sodium thiosulfate preserved the mitochondria in response to ischemia-reperfusion injury.

J Bioenerg Biomembr 2019 Mar 30. Epub 2019 Mar 30.

Vascular Biology Lab, SASTRA-Deemed University, Thanjavur, Tamilnadu, 613401, India.

Sodium thiosulfate preconditioning (SIPC) was recently reported to be cardioprotective due to its ability to inhibit caspase-3 activation, chelate calcium ions and scavenge free radicals. However, the rationale behind its ability to improve the contractility of isolated rat heart challenged with ischemia-reperfusion injury (IR) is not well understood. As mitochondrial preservation is implicated in cardioprotection against IR, the present study was conceived to identify whether the cardioprotective effects of SIPC is associated with mitochondrial preservation. Read More

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http://dx.doi.org/10.1007/s10863-019-09794-8DOI Listing

The synergistic effect of mefenamic acid with ionizing radiation in colon cancer.

J Bioenerg Biomembr 2019 Mar 7. Epub 2019 Mar 7.

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Despite radiotherapy is an effective regimen in cancer treatment, resistance to tumor therapy still is a major challenge to radiotherapy and results in cancer recurrence and metastasis. Then the sensitization of tumor cells to ionizing radiation (IR) would be beneficial in cancer treatment. The aim of this study was to evaluate the synergistic effect of mefenamic acid (MEF) on colon cancer cell (HT-29) exposure to IR. Read More

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http://dx.doi.org/10.1007/s10863-019-09792-wDOI Listing
March 2019
1 Read

Ropivacaine inhibits tumor angiogenesis via sodium-channel-independent mitochondrial dysfunction and oxidative stress.

J Bioenerg Biomembr 2019 Mar 7. Epub 2019 Mar 7.

Department of Basic Medical Research, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.

The anti-cancer role of local anesthetics has garnered attention in recent years because increasing evidence show that local anesthetics reduce the risk of tumor metastasis and recurrence. Angiogenesis, the formation of new blood vessels, is fundamental for tumor growth and metastasis. The role of local anesthetics on tumor angiogenesis still remains unknown. Read More

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http://dx.doi.org/10.1007/s10863-019-09793-9DOI Listing
March 2019
2 Reads

3D structure prediction of VAPC1 and identification of dual natural inhibitors for VPAC1 and EGFR.

J Bioenerg Biomembr 2019 Apr 27;51(2):89-102. Epub 2019 Feb 27.

School of Bio Sciences & Technology, VIT, Vellore, Tamil Nadu, 632014, India.

Vasoactive intestinal polypeptide receptor 1 (VPAC1) and epidermal growth factor receptor (EGFR) are associated with signal transduction pathways relevant to neuroblastoma, cancer of breast, prostate and lungs. In order to identify appropriate ligand analogues for simultaneous inhibition of EGFR and VPAC1, in-silico homology modelling of VPAC1 and its characterization by molecular interaction studies have been undertaken. Homology modelling was performed with the Swiss Model and validation of the predicted 3D structure was carried out using PROCHECK and RAMPAGE. Read More

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http://dx.doi.org/10.1007/s10863-019-09790-yDOI Listing
April 2019
1 Read

Mitochondrial uncoupling proteins UCP4 and UCP5 from the Pacific white shrimp Litopenaeus vannamei.

J Bioenerg Biomembr 2019 Apr 22;51(2):103-119. Epub 2019 Feb 22.

Bioenergetics and Molecular Genetics Lab, Centro de Investigacion en Alimentacion y Desarrollo, A. C. Carretera a Ejido La Victoria Km 0.6, PO Box 1735, 83000, Hermosillo, Sonora, Mexico.

Mitochondrial uncoupling proteins (UCP) transport protons from the intermembrane space to the mitochondrial matrix uncoupling oxidative phosphorylation. In mammals, these proteins have been implicated in several cellular functions ranging from thermoregulation to antioxidant defense. In contrast, their invertebrate homologs have been much less studied despite the great diversity of species. Read More

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http://dx.doi.org/10.1007/s10863-019-09789-5DOI Listing
April 2019
1 Read

Carbonic anhydrase-IX inhibition enhances the efficacy of hexokinase II inhibitor for hepatocellular carcinoma in a murine model.

J Bioenerg Biomembr 2019 Apr 12;51(2):121-129. Epub 2019 Feb 12.

Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.

Hypoxic conditions, which large or infiltrative hypovascular tumors may encounter, also produce acidic environments. Carbonic anhydrase-IX (CA-IX), an enzyme involved in lowering pH, is overexpressed in hepatocellular carcinoma (HCC). In the present study, whether inhibition of CA-IX enhances the efficacy of a hexokinase II inhibitor in an in vivo murine model was examined and its prognostic implication in HCC patients was investigated. Read More

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http://dx.doi.org/10.1007/s10863-019-09788-6DOI Listing
April 2019
2 Reads
3.212 Impact Factor

Phytosterol containing diet increases plasma and whole body concentration of phytosterols in apoE-KO but not in LDLR-KO mice.

J Bioenerg Biomembr 2019 Apr 9;51(2):131-136. Epub 2019 Feb 9.

Laboratorio de Lipides, LIM-10, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455 - room 3305, São Paulo, SP, CEP 01246-000, Brazil.

Phytosterol metabolism is unknown in the hypercholesterolemia of genetic origin. We investigated the metabolism of phytosterols in a cholesterol-free, phytosterol-containing standard diet in hypercholesterolemic mice knockouts for low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) mice compared to wild-type mice (controls). Phytosterols were measured in mice tissues by GCMS. Read More

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http://dx.doi.org/10.1007/s10863-019-09786-8DOI Listing
April 2019
1 Read

Introduction to the special issue of the journal of bioenergetics and biomembranes: neural plasticity in developing and adult olfactory pathways.

Authors:
David M Coppola

J Bioenerg Biomembr 2019 Feb;51(1):1-2

Department of Biology, Randolph-Macon College, Ashland, VA, 23005, USA.

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http://dx.doi.org/10.1007/s10863-019-09787-7DOI Listing
February 2019
1 Read

Hydrophobicity, rather than secondary structure, is essential for the SRP dependent targeting of GPR35 to the ER membrane.

J Bioenerg Biomembr 2019 Apr 31;51(2):137-150. Epub 2019 Jan 31.

Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.

The folding and targeting of hydrophobic transmembrane domains poses a major challenge to the cell. Several membrane proteins have been shown to gain some degree of secondary structure within the ribosome tunnel and to retain this conformation throughout maturation. However, there is little information on one of the largest classes of eukaryotic membrane proteins; the G protein-coupled receptors (GPCRs). Read More

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http://dx.doi.org/10.1007/s10863-019-9785-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439181PMC

Polymorphisms in plastoquinol oxidase (PTOX) from Arabidopsis accessions indicate SNP-induced structural variants associated with altitude and rainfall.

J Bioenerg Biomembr 2019 Apr 7;51(2):151-164. Epub 2019 Jan 7.

Functional Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Ceara, Fortaleza, 60451-970, Brazil.

Plant plastoquinol oxidase (PTOX) is a chloroplast oxidoreductase involved in carotenoid biosynthesis, chlororespiration, and response to environmental stresses. The present study aimed to gain insight of the potential role of nucleotide/amino acid changes linked to environmental adaptation in PTOX gene/protein from Arabidopsis thaliana accessions. SNPs in the single-copy PTOX gene were identified in 1190 accessions of Arabidopsis using the Columbia-0 PTOX as a reference. Read More

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http://link.springer.com/10.1007/s10863-018-9784-6
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http://dx.doi.org/10.1007/s10863-018-9784-6DOI Listing
April 2019
11 Reads

Post-stroke fatigue as an indicator of underlying bioenergetics alterations.

J Bioenerg Biomembr 2019 Apr 7;51(2):165-174. Epub 2019 Jan 7.

University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA.

Approximately half of stroke survivors suffer from clinically significant fatigue, contributing to poor quality of life, depression, dependency, and increased mortality. The etiology of post-stroke fatigue is not well understood and treatment is limited. This study tested the hypothesis that systemic aerobic energy metabolism, as reflected by platelet oxygen consumption, is negatively associated with fatigue and systemic inflammation is positively associated with fatigue in chronic ischemic stroke survivors. Read More

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http://link.springer.com/10.1007/s10863-018-9782-8
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http://dx.doi.org/10.1007/s10863-018-9782-8DOI Listing
April 2019
10 Reads

Thylakoid membrane unstacking increases LHCII thermal stability and lipid phase fluidity.

J Bioenerg Biomembr 2018 Dec 3;50(6):425-435. Epub 2019 Jan 3.

Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Thylakoids are highly protein-enriched membranes that harbor a number of multicomponent photosynthetic complexes. Similarly to other biological membranes the protein constituents are heterogeneously distributed laterally in the plane of the membrane, however the specific segregation into stacked (grana patches) and unstacked (stroma lamellae) membrane layers is a unique feature of the thylakoid. Both the lateral and the vertical arrangements of the integral membrane proteins within the three-dimensional thylakoid ultrastructure are thought to have important physiological function. Read More

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http://dx.doi.org/10.1007/s10863-018-9783-7DOI Listing
December 2018
3 Reads

Neural plasticity in developing and adult olfactory pathways - focus on the human olfactory bulb.

J Bioenerg Biomembr 2019 Feb 3;51(1):77-87. Epub 2019 Jan 3.

Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.

The topic of human adult neural plasticity and neurogenesis is of great interest for medical and scientific community, but it is also largely debated. In the last years, an increasing interest has been paid to the olfactory system, and particularly to the plasticity of the olfactory bulb (OB). While the molecular/cellular mechanisms underlying OB plasticity remain a matter of debate, measurements of the OB using magnetic resonance imaging clearly indicate that it is a highly plastic structure. Read More

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http://dx.doi.org/10.1007/s10863-018-9780-xDOI Listing
February 2019
2 Reads

Lack of activation of the S113L variant of carnitine palmitoyltransfersase II by cardiolipin.

J Bioenerg Biomembr 2018 Dec 3;50(6):461-466. Epub 2019 Jan 3.

Department of Neurology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle (Saale), Germany.

The phospholipid environment of the mitochondrial inner membrane, which contains large amounts of cardiolipin, could play a key role in transport of the long chain fatty acids. In the present study, the pre-incubation of cardiolipin with the wild type carnitine palmitoyltransferase (CPT) II led to a more than 1.5-fold increase of enzyme activity at physiological temperatures. Read More

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http://dx.doi.org/10.1007/s10863-018-9781-9DOI Listing
December 2018
2 Reads

Strength in diversity: functional diversity among olfactory neurons of the same type.

J Bioenerg Biomembr 2019 Feb 2;51(1):65-75. Epub 2019 Jan 2.

Department of Biology, University of Nevada, 1664 N. Virginia St., MS: 0314, Reno, NV, 89557, USA.

Most animals depend upon olfaction to find food, mates, and to avoid predators. An animal's olfactory circuit helps it sense its olfactory environment and generate critical behavioral responses. The general architecture of the olfactory circuit, which is conserved across species, is made up of a few different neuronal types including first-order receptor neurons, second- and third-order neurons, and local interneurons. Read More

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http://dx.doi.org/10.1007/s10863-018-9779-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382560PMC
February 2019
2 Reads

BIOMEMBRANES 2018 : International Conference 1-5 October 2018 Book of Abstracts.

Authors:

J Bioenerg Biomembr 2018 Dec;50(6):467-603

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http://dx.doi.org/10.1007/s10863-018-9775-7DOI Listing
December 2018
1 Read

Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction.

J Bioenerg Biomembr 2019 Feb 12;51(1):53-63. Epub 2018 Nov 12.

Department of Neurology, Duke Institute for Brain Sciences, Duke University School of Medicine, Durham, NC, 27708, USA.

The critical period concept has been one of the most transcendent in science, education, and society forming the basis of our fixation on 'quality' of childhood experiences. The neural basis of this process has been revealed in developmental studies of visual, auditory and somatosensory maps and their enduring modification through manipulations of experience early in life. Olfaction, too, possesses a number of phenomena that share key characteristics with classical critical periods like sensitive temporal windows and experience dependence. Read More

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http://link.springer.com/10.1007/s10863-018-9778-4
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http://dx.doi.org/10.1007/s10863-018-9778-4DOI Listing
February 2019
19 Reads

An integrated molecular modeling approach for the tryptase monomer-curcuminoid recognition analysis: conformational and bioenergetic features.

J Bioenerg Biomembr 2018 Dec 10;50(6):447-459. Epub 2018 Nov 10.

Laboratory for Molecular Design and Simulation (LMDS), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.

Human mast cell tryptase has been shown as an activating enzyme in matrix degradation process. The previous study suggest that tryptase either alone or in joining with activation of metalloproteinases, can associate in extra cellular matrix damage and the possible destruction of the basement membrane resulting in photoaging. Therefore the inhibition of tryptase activity is one of the most important therapeutic strategies against the photoaging. Read More

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http://link.springer.com/10.1007/s10863-018-9777-5
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http://dx.doi.org/10.1007/s10863-018-9777-5DOI Listing
December 2018
15 Reads
3.212 Impact Factor

Pioglitazone provides beneficial effect in metabolic syndrome rats via affecting intracellular Na Dyshomeostasis.

J Bioenerg Biomembr 2018 Dec 25;50(6):437-445. Epub 2018 Oct 25.

Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Turkey.

Metabolic syndrome, is associated impaired blood glucose level, insulin resistance, and dyslipidemia caused by abdominal obesity. Also, it is related with cardiovascular risk accumulation and cardiomyopathy. The hypothesis of this study was to examine the effect of thiazolidinediones such as pioglitazone on intracellular Na homeostasis in heart of metabolic syndrome male rats. Read More

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http://dx.doi.org/10.1007/s10863-018-9776-6DOI Listing
December 2018
19 Reads

Low survival rate of young adult-born olfactory sensory neurons in the undamaged mouse olfactory epithelium.

J Bioenerg Biomembr 2019 Feb 9;51(1):41-51. Epub 2018 Oct 9.

Department of Neurobiology, University of Pittsburgh, 200 Lothrop St., BST E1456, Pittsburgh, PA, 15213, USA.

Olfactory sensory neurons (OSNs) are generated throughout life from progenitor cells in the olfactory epithelium. OSN axons project in an odorant receptor-specific manner to the olfactory bulb (OB), forming an ordered array of glomeruli where they provide sensory input to OB neurons. The tetracycline transactivator (tTA) system permits developmental stage-specific expression of reporter genes in OSNs and has been widely used for structural and functional studies of the development and plasticity of the mouse olfactory system. Read More

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http://dx.doi.org/10.1007/s10863-018-9774-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382611PMC
February 2019
2 Reads

Control of rotation of the FF-ATP synthase nanomotor by an inhibitory α-helix from unfolded ε or intrinsically disordered ζ and IF proteins.

J Bioenerg Biomembr 2018 Oct 28;50(5):403-424. Epub 2018 Sep 28.

Departamento de Biología, Facultad de Química, Ciudad Universitaria, Universidad Nacional Autónoma de México (U.N.A.M.), Circuito Escolar s/n. Laboratorio 203, Edificio "F"., Delegación Coyoacán, 04510, Mexico City, CP, Mexico.

The ATP synthase is a ubiquitous nanomotor that fuels life by the synthesis of the chemical energy of ATP. In order to synthesize ATP, this enzyme is capable of rotating its central rotor in a reversible manner. In the clockwise (CW) direction, it functions as ATP synthase, while in counter clockwise (CCW) sense it functions as an proton pumping ATPase. Read More

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http://dx.doi.org/10.1007/s10863-018-9773-9DOI Listing
October 2018
11 Reads

Deafferentation-induced alterations in mitral cell dendritic morphology in the adult zebrafish olfactory bulb.

J Bioenerg Biomembr 2019 Feb 13;51(1):29-40. Epub 2018 Sep 13.

Department of Biological Sciences, Western Michigan University, 1903 W. Michigan Ave, Kalamazoo, MI, 49008-5410, USA.

The removal of afferent input to the olfactory bulb by both cautery and chemical olfactory organ ablation in adult zebrafish results in a significant decrease in volume of the ipsilateral olfactory bulb. To examine the effects of deafferentation at a cellular level, primary output neurons of the olfactory bulb, the mitral cells, were investigated using retrograde tract tracing with fluorescent dextran using ex vivo brain cultures. Morphological characteristics including the number of major dendritic branches, total length of dendritic branches, area of the dendritic arbor, overall dendritic complexity, and optical density of the arbor were used to determine the effects of deafferentation on mitral cell dendrites. Read More

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http://dx.doi.org/10.1007/s10863-018-9772-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450569PMC
February 2019
4 Reads

Loss of odor-induced c-Fos expression of juxtaglomerular activity following maintenance of mice on fatty diets.

J Bioenerg Biomembr 2019 Feb 11;51(1):3-13. Epub 2018 Sep 11.

Department of Biological Science, The Florida State University, KIN Life Science Building, 319 Stadium Drive, Suite 3014, Tallahassee, FL, 32306, USA.

Diet-induced obesity (DIO) decreases the number of OMP+ olfactory sensory neurons (OSN) in the olfactory epithelium by 25% and reduces correlate axonal projections to the olfactory bulb (OB). Whether surviving OSNs have equivalent odor responsivity is largely unknown. Herein, we utilized c-fos immediate-early gene expression to map neuronal activity and determine whether mice weaned to control (CF), moderately-high fat (MHF), or high-fat (HF) diet for a period of 6 months had changes in odor activation. Read More

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http://link.springer.com/10.1007/s10863-018-9769-5
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http://dx.doi.org/10.1007/s10863-018-9769-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382583PMC
February 2019
12 Reads
3.212 Impact Factor

Membranotropic effects of ω-hydroxypalmitic acid and Ca on rat liver mitochondria and lecithin liposomes. Aggregation and membrane permeabilization.

J Bioenerg Biomembr 2018 Oct 5;50(5):391-401. Epub 2018 Sep 5.

Mari State University, pl. Lenina 1, Yoshkar-Ola, Mari El, 424001, Russia.

The paper examines membranotropic Ca-dependent effects of ω-hydroxypalmitic acid (HPA), a product of ω-oxidation of fatty acids, on the isolated rat liver mitochondria and artificial membrane systems (liposomes). It was established that in the presence of Ca, HPA induced aggregation of liver mitochondria, which was accompanied by the release of cytochrome c from the organelles. It was further demonstrated that the addition of Ca to HPA-containing liposomes induced their aggregation and/or fusion. Read More

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http://dx.doi.org/10.1007/s10863-018-9771-yDOI Listing
October 2018
9 Reads

Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.

J Bioenerg Biomembr 2019 Feb 31;51(1):15-27. Epub 2018 Aug 31.

Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38134, USA.

Experiences, such as sensory learning, are known to induce plasticity in mammalian sensory systems. In recent years aversive olfactory learning-induced plasticity has been identified at all stages of the adult olfactory pathway; however, the underlying mechanisms have yet to be identified. Much of the work regarding mechanisms of olfactory associative learning comes from neonates, a time point before which the brain or olfactory system is fully developed. Read More

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http://dx.doi.org/10.1007/s10863-018-9770-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382525PMC
February 2019
2 Reads

Altered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy.

J Bioenerg Biomembr 2018 Oct 24;50(5):379-390. Epub 2018 Aug 24.

Equine Pole, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, Liège, Belgium.

Polysaccharide storage myopathy (PSSM) is a widely described cause of exertional rhabdomyolysis in horses. Mitochondria play a central role in cellular energetics and are involved in human glycogen storage diseases but their role has been overlooked in equine PSSM. We hypothesized that the mitochondrial function is impaired in the myofibers of PSSM-affected horses. Read More

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http://dx.doi.org/10.1007/s10863-018-9768-6DOI Listing
October 2018
4 Reads

Mitochondrial NADH redox potential impacts the reactive oxygen species production of reverse Electron transfer through complex I.

J Bioenerg Biomembr 2018 Oct 22;50(5):367-377. Epub 2018 Aug 22.

Université Grenoble Alpes, INSERM, LBFA, Grenoble, France.

There is substantial evidence that Reactive Oxygen Species (ROS) play a major part in cell functioning. Although their harmfulness through oxidative stress is well documented, their role in signaling and sensing as an oxidative signal still needs to be investigated. In most cells, the mitochondrial Electron Transport Chain (ETC) is the primary source of ROS. Read More

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http://dx.doi.org/10.1007/s10863-018-9767-7DOI Listing
October 2018
9 Reads

Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria.

J Bioenerg Biomembr 2018 Oct 17;50(5):355-365. Epub 2018 Aug 17.

Department of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 37-47 Tűzoltó St, Budapest, 1094, Hungary.

Succinate-driven reverse electron transport (RET) is one of the main sources of mitochondrial reactive oxygen species (mtROS) in ischemia-reperfusion injury. RET is dependent on mitochondrial membrane potential (Δψ) and transmembrane pH difference (ΔpH), components of the proton motive force (pmf); a decrease in Δψ and/or ΔpH inhibits RET. In this study we aimed to determine which component of the pmf displays the more dominant effect on RET-provoked ROS generation in isolated guinea pig brain and heart mitochondria respiring on succinate or α-glycerophosphate (α-GP). Read More

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http://link.springer.com/10.1007/s10863-018-9766-8
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http://dx.doi.org/10.1007/s10863-018-9766-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209044PMC
October 2018
18 Reads

The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins.

J Bioenerg Biomembr 2018 Oct 12;50(5):339-354. Epub 2018 Jul 12.

Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618, Tallinn, Estonia.

Previous studies have shown that class II β-tubulin plays a key role in the regulation of oxidative phosphorylation (OXPHOS) in some highly differentiated cells, but its role in malignant cells has remained unclear. To clarify these aspects, we compared the bioenergetic properties of HL-1 murine sarcoma cells, murine neuroblastoma cells (uN2a) and retinoic acid - differentiated N2a cells (dN2a). We examined the expression and possible co-localization of mitochondrial voltage dependent anion channel (VDAC) with hexokinase-2 (HK-2) and βII-tubulin, the role of depolymerized βII-tubuline and the effect of both proteins in the regulation of mitochondrial outer membrane (MOM) permeability. Read More

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http://dx.doi.org/10.1007/s10863-018-9765-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209068PMC
October 2018
6 Reads

Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines.

J Bioenerg Biomembr 2018 Oct 25;50(5):329-338. Epub 2018 Jun 25.

Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50161, Kaunas, Lithuania.

Gastrointestinal cancers (gastric, pancreatic and colorectal) are life-threatening diseases, which easily spread to peritoneal cavity (Juhl et al. in Int J Cancer 57:330-335, 1994; Schneider et al. in Gastroenterology 128:1606-1625, 2005; Geer and Brennan in Am J Surg 165:68-72 1993). Read More

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http://dx.doi.org/10.1007/s10863-018-9764-xDOI Listing
October 2018
22 Reads

Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?

J Bioenerg Biomembr 2018 Aug 7;50(4):307-313. Epub 2018 Jun 7.

Laboratory of Toxoplasmosis and other Protozoans, FIOCRUZ, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.

Purinergic receptors are widespread in the human organism and are involved in several physiological functions like neurotransmission, nociception, platelet aggregation, etc. In the immune system, they may regulate the expression and release of pro-inflammatory factors as well as the activation and death of several cell types. It is already described the participation of some purinergic receptors in the inflammation and pathological processes, such as a few neglected tropical diseases (NTDs) which affect more than 1 billion people in the world. Read More

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http://dx.doi.org/10.1007/s10863-018-9761-0DOI Listing
August 2018
5 Reads

Downregulation of monocarboxylate transporter 1 inhibits the invasion and migration through suppression of the PI3K/Akt signaling pathway in human nasopharyngeal carcinoma cells.

J Bioenerg Biomembr 2018 Aug 7;50(4):271-281. Epub 2018 Jun 7.

School of Pharmacy, Bengbu Medical College, Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu, 233030, Anhui, People's Republic of China.

Monocarboxylate transporter 1 (MCT1) has been reported to be correlated wtih decreased survival and advanced stage of progression in a series of human tumor cells and primary cancers. Specifically, MCT1 has been documented to be involved in tumor progression, including invasion and migration. Here, we investigated the mechanism and effect of regulation of MCT1 on invasion and migration of nasopharyngeal carcinoma (NPC) cells. Read More

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http://dx.doi.org/10.1007/s10863-018-9763-yDOI Listing
August 2018
6 Reads
3.210 Impact Factor

New ways of thinking about old things: the role of O-GlcNAc in cellular metabolism.

Authors:
Chad Slawson

J Bioenerg Biomembr 2018 06 29;50(3):153-154. Epub 2018 May 29.

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.

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http://dx.doi.org/10.1007/s10863-018-9762-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994169PMC
June 2018
2 Reads

O-GlcNAc cycling in the developing, adult and geriatric brain.

Authors:
Olof Lagerlöf

J Bioenerg Biomembr 2018 06 22;50(3):241-261. Epub 2018 May 22.

Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden.

Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc. A single protein is often O-GlcNAcylated on several amino acids and the modification of a single site can play a crucial role for the function of the protein. Despite its complexity, only two enzymes add and remove O-GlcNAc from proteins, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Read More

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http://dx.doi.org/10.1007/s10863-018-9760-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984647PMC
June 2018
3 Reads

Mitochondrial morphology and function impaired by dimethyl sulfoxide and dimethyl Formamide.

J Bioenerg Biomembr 2018 Aug 17;50(4):297-305. Epub 2018 May 17.

State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People's Republic of China.

In this work, the effects of two non-ionic, non-hydroxyl organic solvents, dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF) on the morphology and function of isolated rat hepatic mitochondria were investigated and compared. Mitochondrial ultrastructures impaired by DMSO and DMF were clearly observed by transmission electron microscopy. Spectroscopic and polarographic results demonstrated that organic solvents induced mitochondrial swelling, enhanced the permeation to H/K, collapsed the potential inner mitochondrial membrane (IMM), and increased the IMM fluidity. Read More

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http://dx.doi.org/10.1007/s10863-018-9759-7DOI Listing
August 2018
4 Reads

Formation of lamellar bodies in rat liver mitochondria in hyperthyroidism.

J Bioenerg Biomembr 2018 Aug 3;50(4):289-295. Epub 2018 May 3.

Institute of Theoretical and Experimental Biophysics RAS, Pushchino, Moscow, Region 142290, Russia.

In the present work, ultrastructural changes of rat liver mitochondria in hyperthyroidism were studied. Hyperthyroidism was induced in male Wistar rats by daily administration of 100 μg thyroxin per 100 g body weight for 5 days. The level of triiodothyronine and thyroxine increased 3- and 4-fold, respectively, in comparison with the same parameters in the control group, indicating the development of hyperthyroidism in experimental animals. Read More

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http://dx.doi.org/10.1007/s10863-018-9758-8DOI Listing
August 2018
7 Reads

Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer.

J Bioenerg Biomembr 2018 Aug 23;50(4):263-270. Epub 2018 Apr 23.

Department of Endocrinology, The Third People's Hospital of Guangxi Zhuang Autonomous Region, Riverside Hospital of Guangxi Zhuang Autonomous Region, Heti Road 85, Qingxiu District, Nanning, 530021, China.

The clinical management of anaplastic thyroid carcinoma and follicular thyroid carcinoma is challenging and requires an alternative therapeutic strategy. Although atovaquone is an FDA-approved anti-malarial drug, studies has recently demonstrated its anti-cancer activities. In line with these efforts, our study shows that atovaquone is an attractive candidate for thyroid cancer treatment. Read More

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http://dx.doi.org/10.1007/s10863-018-9755-yDOI Listing
August 2018
17 Reads

Molecular modeling of non-covalent binding of Ligustrum lucidum secoiridoid glucosides to AP-1/matrix metalloproteinase pathway components.

J Bioenerg Biomembr 2018 Aug 23;50(4):315-327. Epub 2018 Apr 23.

Laboratory for Molecular Design and Simulation (LMDS), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.

Ligustrum lucidum secoiridoid glucosides have been demonstrated to treat various types of diseases such as inflammation, pain, hepatotoxicity and hyperlipidermic as well as tonic for liver and kidney. Matrix metalloproteinases (MMPs) play a key role upon the pathology of photoaging. The present computational study showed that among the six secoiridoid glucosides (ligustroside, lucidumoside A, lucidumoside C, neonuezhenide, oleoside dimethylester, and oleuropein), ligustroside and lucidumoside A competitively inhibit all MMP-1, MMP-3, and MMP-9 activities in the docking models. Read More

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http://dx.doi.org/10.1007/s10863-018-9756-xDOI Listing
August 2018
8 Reads

Decreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice.

J Bioenerg Biomembr 2018 Aug 20;50(4):283-287. Epub 2018 Apr 20.

Laboratorio de Lipides, LIM-10, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Arnaldo, 455 - room 3305, São Paulo, SP, CEP 01246-000, Brazil.

Apolipoprotein E knockout (apoE-KO) mice present synaptic loss, cognitive dysfunction, and high plasma lipid levels that may affect brain function simulating Alzheimer disease. Plasma and brain sterols were measured in apoE-KO and in wild type control mice on a cholesterol-free, phytosterol-containing diet by gas chromatography coupled to a mass spectrometer. Plasma cholesterol and phytosterols (campesterol and sitosterol) were higher in apoE-KO compared to control mice. Read More

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http://dx.doi.org/10.1007/s10863-018-9757-9DOI Listing
August 2018
4 Reads

New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT.

J Bioenerg Biomembr 2018 06 18;50(3):231-240. Epub 2018 Apr 18.

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.

O-GlcNAcylation is a dynamic and functionally diverse post-translational modification shown to affect thousands of proteins, including the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (Nod2). Mutations of Nod2 (R702W, G908R and 1007 fs) are associated with Crohn's disease and have lower stabilities compared to wild type. Cycloheximide (CHX)-chase half-life assays have been used to show that O-GlcNAcylation increases the stability and response of both wild type and Crohn's variant Nod2, R702W. Read More

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http://dx.doi.org/10.1007/s10863-018-9754-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126917PMC
June 2018
10 Reads

O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle.

J Bioenerg Biomembr 2018 06 29;50(3):155-173. Epub 2018 Mar 29.

Laboratory of Cell Biochemistry and Molecular Biology, NIDDK, NIH, Bldg 8 Rm B1 27, 9000 Rockville Pike, Bethesda, MD, 20892-0851, USA.

Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose and glutamine, the hexosamine biosynthetic pathway (HBP) sustains glycosylation in the endomembrane system. In addition, the elevated pools of UDP-GlcNAc drives the O-GlcNAc modification of key targets in the cytoplasm, nucleus and mitochondrion. Read More

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http://dx.doi.org/10.1007/s10863-018-9751-2DOI Listing
June 2018
16 Reads

Alternative mitochondrial respiratory chains from two crustaceans: Artemia franciscana nauplii and the white shrimp, Litopenaeus vannamei.

J Bioenerg Biomembr 2018 04 29;50(2):143-152. Epub 2018 Mar 29.

Bioenergetics and Molecular Genetics Laboratory, Centro de Investigacion en Alimentacion y Desarrollo (CIAD), A. C. Carretera a Ejido La Victoria Km 0.6, PO Box. 1735, 83000, Hermosillo, Sonora, Mexico.

Mitochondrial ATP is synthesized by coupling between the electron transport chain and complex V. In contrast, physiological uncoupling of these processes allows mitochondria to consume oxygen at high rates without ATP synthesis. Such uncoupling mechanisms prevent reactive oxygen species overproduction. Read More

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http://dx.doi.org/10.1007/s10863-018-9753-0DOI Listing
April 2018
9 Reads

Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway.

J Bioenerg Biomembr 2018 04 28;50(2):93-105. Epub 2018 Mar 28.

Laboratório de Oncobiologia Molecular (LabOMol), Departamento de Biotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Breast cancer is the major cause of death by cancer in women worldwide and in spite of the many drugs for its treatment, there is still the need for novel therapies for its control. Ocimum species have been used by traditional medicine to control several diseases, including cancer. We have previously characterized the antidiabetic properties of the unfractionated aqueous leaf extracts of Ocimum basilicum (OB) and Ocimum gratissimum (OG), modulating glucose metabolism in diabetic mice. Read More

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http://dx.doi.org/10.1007/s10863-018-9750-3DOI Listing
April 2018
7 Reads

Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition.

J Bioenerg Biomembr 2018 04 27;50(2):131-142. Epub 2018 Mar 27.

DMEM, INRA, Université de Montpellier, Montpellier, France.

Cardiolipin (CL) is a phospholipid at the heart of mitochondrial metabolism, which plays a key role in mitochondrial function and bioenergetics. Among mitochondrial activity regulators, SIRT3 plays a crucial role in controlling the acetylation status of many enzymes participating in the energy metabolism in particular concerning lipid metabolism and fatty acid oxidation. Data suggest that possible connection may exist between SIRT3 and CL status that has not been evaluated in skeletal muscle. Read More

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http://dx.doi.org/10.1007/s10863-018-9752-1DOI Listing
April 2018
8 Reads

Cross regulation between mTOR signaling and O-GlcNAcylation.

J Bioenerg Biomembr 2018 06 9;50(3):213-222. Epub 2018 Mar 9.

CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Université de Lille, F 59000, Lille, France.

The hexosamine biosynthetic pathway (HBP) integrates glucose, amino acids, fatty acids and nucleotides metabolisms for uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) synthesis. UDP-GlcNAc is the nucleotide sugar donor for O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) processes. O-GlcNAc transferase (OGT) is the enzyme which transfers the N-acetylglucosamine (O-GlcNAc) residue onto target proteins. Read More

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http://dx.doi.org/10.1007/s10863-018-9747-yDOI Listing
June 2018
5 Reads

Aberrant GSH reductase and NOX activities concur with defective CFTR to pro-oxidative imbalance in cystic fibrosis airways.

J Bioenerg Biomembr 2018 04 9;50(2):117-129. Epub 2018 Mar 9.

Istituto di Biomembrane, Bioenergetica e Biotecnologie Molecolari (IBIOM) - CNR, Via G. Amendola 165/A, 70126, Bari, Italy.

Cystic fibrosis (CF) is associated to impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel also causing decreased glutathione (GSH) secretion, defective airway bacterial clearance and inflammation. Here we checked the main ROS-producing and ROS-scavenging enzymes as potential additional factors involved in CF pathogenesis. We found that CFBE41o-cells, expressing F508del CFTR, have increased NADPH oxidase (NOX) activity and expression level, mainly responsible of the increased ROS production, and decreased glutathione reductase (GR) activity, not dependent on GR protein level decrease. Read More

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http://link.springer.com/10.1007/s10863-018-9748-x
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http://dx.doi.org/10.1007/s10863-018-9748-xDOI Listing
April 2018
9 Reads

The cytotoxic, apoptotic and oxidative effects of carbonic anhydrase IX inhibitor on colorectal cancer cells.

J Bioenerg Biomembr 2018 04 9;50(2):107-116. Epub 2018 Mar 9.

Faculty of Science and Art, Department of Chemistry, Harran University, Şanlıurfa, Turkey.

Colorectal cancer (CRC) is the third most common tumor, malignant and has developed one of the main reasons of cancer mortality. According to studies conducted recently; carbonic anhydrase 9 (CAIX) is an especially attractive target for cancer therapy, in part since it is limited way expressed in normal tissues on the other hand in a wide variety of solid neoplasia are overexpressed. The aim of this study was to appreciate the effects of CAIX inhibitor, namely novel synthesized sulfonamide derivative (H-4i) with high affinity for CAIX, in CAIX-positive human colorectal cancer cell (HT-29) and CAIX-negative human normal embryonic kidney cell line (HEK-293). Read More

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http://dx.doi.org/10.1007/s10863-018-9749-9DOI Listing
April 2018
9 Reads

Searching for new drugs for Chagas diseases: triazole analogs display high in vitro activity against Trypanosoma cruzi and low toxicity toward mammalian cells.

J Bioenerg Biomembr 2018 04 23;50(2):81-91. Epub 2018 Feb 23.

Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ, CEP 24020-150, Brazil.

Chagas disease is one of the most relevant endemic diseases in Latin America caused by the flagellate protozoan Trypanosoma cruzi. Nifurtimox and benzonidazole are the drugs used in the treatment of this disease, but they commonly are toxic and present severe side effects. New effective molecules, without collateral effects, has promoted the investigation to develop new lead compounds with to advance for clinical trials. Read More

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http://link.springer.com/10.1007/s10863-018-9746-z
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http://dx.doi.org/10.1007/s10863-018-9746-zDOI Listing
April 2018
13 Reads

Investigation of the phosphatidylserine binding properties of the lipid biosensor, Lactadherin C2 (LactC2), in different membrane environments.

J Bioenerg Biomembr 2018 02 10;50(1):1-10. Epub 2018 Feb 10.

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA.

Lipid biosensors are robust tools used in both in vitro and in vivo applications of lipid imaging and lipid detection. Lactadherin C2 (LactC2) was described in 2000 as being a potent and specific sensor for phosphatidylserine (PS) (Andersen et al. Biochemistry 39:6200-6206, 2000). Read More

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http://dx.doi.org/10.1007/s10863-018-9745-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820145PMC
February 2018
10 Reads