2,696 results match your criteria Journal of andrology[Journal]


Parting messages from current and former editors of the Journal of Andrology.

J Androl 2012 Nov-Dec;33(6):1068-74. Epub 2012 Aug 9.

The proposal to produce this final commemorative issue for the Journal of Andrology arose during our regular discussions as current editors soon after it was announced that the Journal would complete its own life course and merge into a new publication (to be named Andrology) with the International Journal of Andrology. We considered the momentous occasion to be one that should be celebrated with an enduring tribute in recognition of the Journal's exceptional 33-year existence. Among the various contributions sought for inclusion in this issue, we envisioned an article assembling collected short essays from all living former editors drawing on notable events and highlights, if not less well-known challenges and successes arising during their editorship eras. Read More

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http://dx.doi.org/10.2164/jandrol.112.017475DOI Listing
October 2014
13 Reads

Evolution of the Journal of Andrology and a bright future for Andrology.

J Androl 2012 Nov-Dec;33(6):1119-24. Epub 2012 Aug 9.

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http://dx.doi.org/10.2164/jandrol.112.017368DOI Listing
October 2014
2 Reads

Management of erectile dysfunction: great progress, greater promise.

J Androl 2012 Nov-Dec;33(6):1107-10. Epub 2012 Aug 9.

Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.

Sexual medicine, exemplified by the management of erectile dysfunction, is a traditional pillar of andrology. Erectile dysfunction has received the greatest attention within the specialty area and its management models the progress of the field more generally. This review provides a perspective of the history and contemporary practice of erectile dysfunction management, highlighting aspects of basic science research, epidemiology, and clinical care. Read More

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http://dx.doi.org/10.2164/jandrol.112.017228DOI Listing
October 2014
6 Reads

Aging and declining testosterone: past, present, and hopes for the future.

J Androl 2012 Nov-Dec;33(6):1111-8. Epub 2012 Aug 9.

Department of Biochemistry and Molecular Biology, Johns Hopkins University, Baltimore, Maryland, USA.

As men age, serum testosterone (T) levels decline, whereas serum luteinizing hormone (LH) levels increase somewhat or remain unchanged. Age-related reductions in T levels may be associated with alterations in body composition; energy level; muscle strength; physical, sexual, and cognitive functions; and mood. The predominant contributor to the decline in serum T levels is the decreased ability of the aging testes to make T. Read More

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http://dx.doi.org/10.2164/jandrol.112.017160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077344PMC
October 2014
2 Reads

The genetics of male fertility--from basic science to clinical evaluation.

J Androl 2012 Nov-Dec;33(6):1075-84. Epub 2012 Aug 9.

Scott Department of Urology, Baylor College of Medicine, 1 Baylor Plaza, Alkek N730, Houston, Texas 77030, USA.

Our understanding of male fertility has increased dramatically over the past several decades, in large part because of advances in technology and the ability to rapidly analyze large quantities of high-resolution genetic data. These research efforts have led to an understanding of some of the genes involved in male fertility and have enabled us to test for defects in these genes that result in infertility in men. However, our understanding of male fertility remains far from comprehensive, and many genes involved in male fertility likely remain to be identified and their mechanisms of action elucidated. Read More

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http://dx.doi.org/10.2164/jandrol.112.017103DOI Listing
October 2014
1 Read

Questions about spermatogonia posed and answered since 2000.

J Androl 2012 Nov-Dec;33(6):1085-95. Epub 2012 Aug 9.

Department of Endocrinology and Metabolism, Faculty of Science, University of Utrecht, Utrecht, The Netherlands.

This review focuses on 3 important advances in our understanding of rodent spermatogonial stem cells (SSC) that have emerged since 2000: the identity of SSC, the existence of a SSC niche, and gene expression in spermatogonia. It is now apparent that the original scheme, in which the A(single) (A(s)) spermatogonia are the only stem cells, may be too simple. Rather, separation of pairs of A(paired) (A(pr)) spermatogonia into singles might also play a role in the steady state situation. Read More

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http://dx.doi.org/10.2164/jandrol.112.016832DOI Listing
October 2014
6 Reads

Reactive oxygen species and sperm function--in sickness and in health.

J Androl 2012 Nov-Dec;33(6):1096-106. Epub 2012 Aug 9.

Priority Research Centre for Reproductive Biology, Faculty of Science, University of Newcastle, Callaghan, NSW 2308, Australia.

The ability of spermatozoa to generate reactive oxygen species (ROS) has been appreciated since the 1940s. It is a universal property of mature spermatozoa from all mammalian species and a major contributor to the oxidative stress responsible for defective sperm function. The mechanisms by which oxidative stress limits the functional competence of mammalian spermatozoa involve the peroxidation of lipids, the induction of oxidative DNA damage, and the formation of protein adducts. Read More

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http://dx.doi.org/10.2164/jandrol.112.016535DOI Listing
October 2014
3 Reads

The semen quality of 1158 men with testicular cancer at the time of cryopreservation: results of the French National CECOS Network.

J Androl 2012 Nov-Dec;33(6):1394-401. Epub 2012 Jul 26.

Laboratoire de Biologie de la Reproduction–CECOS, Rouen, France.

Testicular cancer is the most common cancer in young men. Several studies have reported an alteration in semen quality in nonseminoma tumors, but this result has not been confirmed in all of the published data. We performed a retrospective study in a population of 1158 men with testicular cancer who banked sperm between 1999 and 2003 in 11 French Centre d'Etude et de Conservation des Oeufs et du Sperme humain laboratories. Read More

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http://dx.doi.org/10.2164/jandrol.112.016592DOI Listing
October 2014
13 Reads

Dietary fat modulates the testosterone pharmacokinetics of a new self-emulsifying formulation of oral testosterone undecanoate in hypogonadal men.

J Androl 2012 Nov-Dec;33(6):1282-90. Epub 2012 Jul 12.

Division of Endocrinology, Department of Medicine and the UCLA–Clinical and Translational Science Institute, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA.

This study investigates the effect of dietary fat on the testosterone (T) pharmacokinetics in hypogonadal men following administration of a self-emulsifying capsule formulation of oral T undecanoate (TU). In an open-label, 2-center, 5-way crossover study, a single oral dose of TU containing 300-mg equivalents of T (maximum anticipated human dose per administration) was administered to 16 hypogonadal men with a washout period of at least 5 days between doses. All participants were randomized to receive the TU capsules fasting or 30 minutes after an approximately 800-calorie meal containing 10%, 20%, 30%, or 50% fat. Read More

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http://dx.doi.org/10.2164/jandrol.112.017020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170073PMC
October 2014
2 Reads

Effects of castration and late hormonal replacement in the structure of rat corpora cavernosa.

J Androl 2012 Nov-Dec;33(6):1224-32. Epub 2012 Jul 12.

Urogenital Research Unit, Rio de Janeiro State University, Rio de Janeiro, Brazil.

The objective of the study was to evaluate, through quantitative methods, the structural alterations in the corpora cavernosa of rats submitted to orchiectomy as well as the role of late hormone replacement in overturning the possible structural alterations. Twenty-five male rats were assigned into 5 groups with 5 animals each and treated as follows: ORCHIEC-1 = submitted to orchiectomy and sacrificed after 1 month; C-1 = control group sacrificed after 1 month; ORCHIEC-2 = submitted to orchiectomy and sacrificed after 2 months; C-2 = control group sacrificed after 2 months; and T = submitted to orchiectomy, underwent testosterone replacement with testosterone undecanoate (100 mg/kg) after 1 month, and sacrificed after 1 month of hormonal replacement. Smooth muscle, collagen, and elastic system fibers of penile corpora cavernosa were quantified. Read More

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http://dx.doi.org/10.2164/jandrol.112.017012DOI Listing
October 2014
6 Reads

Seasonal fluctuations in testosterone-estrogen ratio in men from the Southwest United States.

J Androl 2012 Nov-Dec;33(6):1298-304. Epub 2012 Jul 12.

Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA.

Although controversial, seasonal variations in testosterone have been observed in several populations of men throughout the world. This finding might have an impact on screening and treatment of hypogonadism. We examined the circannual patterns of sex hormones in the Southwest United States. Read More

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http://dx.doi.org/10.2164/jandrol.112.016386DOI Listing
October 2014
5 Reads

Effects of once-daily tadalafil on treatment satisfaction, psychosocial outcomes, spontaneous erections, and measures of endothelial function in men with erectile dysfunction but naive to phosphodiesterase type 5 inhibitors.

J Androl 2012 Nov-Dec;33(6):1305-22. Epub 2012 Jul 12.

Private Practice of Urology and Andrology, Neuer Jungfernstieg 6a, 20354 Hamburg, Germany.

Previous studies established the efficacy of once-daily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5 mg (with possible down-titration to 2. Read More

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http://dx.doi.org/10.2164/jandrol.111.015289DOI Listing
October 2014
17 Reads

Sexual dysfunction following radical prostatectomy.

J Androl 2012 Nov-Dec;33(6):1143-54. Epub 2012 Jun 28.

Department of Urology, Louisiana State University, New Orleans, Louisiana 70112, USA.

Prostate cancer is the most common solid cancer in men and the second leading cause of cancer death in men. A favored treatment option for organ-confined prostate cancer in a middle-aged healthy man is radical prostatectomy (RP). Despite advances in techniques for RP, there remain concerns among physicians and patients alike on its adverse effects on sexual function. Read More

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http://dx.doi.org/10.2164/jandrol.112.016790DOI Listing
October 2014
4 Reads

Prognostic factors in Chinese patients with penile invasive squamous cell carcinoma.

J Androl 2012 Nov-Dec;33(6):1276-81. Epub 2012 Jun 28.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.

The incidence of penile cancer varies by ethnicity and is not well described among Chinese patients. We performed a retrospective study to assess the prognostic factors in Chinese patients with penile invasive squamous cell carcinoma (SCC). We reviewed the medical records of 83 consecutive patients treated at the National Urological Cancer Center (Beijing, China). Read More

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http://dx.doi.org/10.2164/jandrol.112.016378DOI Listing
October 2014
29 Reads

Dr Claude Gagnon.

J Androl 2012 Nov-Dec;33(6):1125-6. Epub 2012 Jun 14.

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http://dx.doi.org/10.2164/jandrol.112.017426DOI Listing
October 2014
1 Read

Cryopreservation of human spermatozoa decreases the number of motile normal spermatozoa, induces nuclear vacuolization and chromatin decondensation.

J Androl 2012 Nov-Dec;33(6):1371-8. Epub 2012 Jun 14.

Department of Reproductive Biology, University Department 2493, Poissy Hospital, Poissy, France.

Even though cryopreservation of human spermatozoa is known to alter sperm motility and viability, it may also induce nuclear damages. The present study set out to determine whether or not cryopreservation alters motile sperm morphology under high magnification and/or is associated with chromatin decondensation. For 25 infertile men, we used high-magnification microscopy to determine the proportions of various types of motile spermatozoa before and after freezing-thawing: morphometrically normal spermatozoa with no vacuole (grade I), ≤ 2 small vacuoles (grade II), at least 1 large vacuole or >2 small vacuoles (grade III), and morphometrically abnormal spermatozoa (grade IV). Read More

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http://dx.doi.org/10.2164/jandrol.112.016980DOI Listing
October 2014
3 Reads

Priapism as the initial manifestation of a penile and lower limb cutaneous metastasis of prostate adenocarcinoma with low serum PSA level.

J Androl 2012 Nov-Dec;33(6):1160-4. Epub 2012 Jun 14.

Department of Urology, The First Affiliated Hospital of the Medical College of Xi'an Jiaotong University, Xi'an, China..

Penile and/or cutaneous metastases from prostate adenocarcinoma rarely occur. Here, we detail the case of a 78-year-old man suffering from priapism caused by metastatic prostate cancer with both penile and lower limb cutaneous spread. His serum prostate-specific antigen level was 0. Read More

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http://dx.doi.org/10.2164/jandrol.112.016873DOI Listing
October 2014
10 Reads

Antiandrogenic activity of resveratrol analogs in prostate cancer LNCaP cells.

J Androl 2012 Nov-Dec;33(6):1208-15. Epub 2012 Jun 14.

Laboratories of Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.

The suppression of androgen signaling is a therapeutic target for the treatment of prostate cancer. Resveratrol (3,4',5-trihydroxystilbene) is known to inhibit the function of the androgen receptor (AR). In the present study, we investigated the antiandrogenic activities of resveratrol analogs in order to identify a potent antiandrogen compound. Read More

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http://dx.doi.org/10.2164/jandrol.112.016782DOI Listing
October 2014
2 Reads

Highly active antiretroviral therapy (HAART) and testicular morphology: current status and a case for a stereologic approach.

Authors:
Onyemaechi O Azu

J Androl 2012 Nov-Dec;33(6):1130-42. Epub 2012 Jun 14.

Discipline of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

As antiretroviral therapy becomes increasingly accessible, the associated improvements in the health, quality of life, and survival of patients are anticipated to influence the fertility determinants of patients, specifically young males, within the reproductive axis. Therefore, the understanding of testicular histology in patients with HIV/AIDS undergoing therapeutic management is essential, because the sexual route is one of the main means of transmission of HIV, which is localized primarily in the germ cells of the testes. It is also important to determine whether any changes have occurred in the testicular histologic patterns in the course of the HIV/AIDS therapy. Read More

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http://doi.wiley.com/10.2164/jandrol.112.016758
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http://dx.doi.org/10.2164/jandrol.112.016758DOI Listing
October 2014
3 Reads

Circulating endothelial cells as marker of endothelial damage in male hypogonadism.

J Androl 2012 Nov-Dec;33(6):1291-7. Epub 2012 Jun 14.

International Scientific Institute Paolo VI, Institute of Biochemistry and Clinical Biochemistry, Universita` Cattolica del S. Cuore, Rome, Italy.

Testosterone deficiency has become a frequently diagnosed condition in today's society affected by epidemic obesity, and is associated with cardiovascular risk. Recent studies have established the importance of altered vascular endothelium function in cardiovascular disease. The damage to the endothelium might also cause endothelial cell detachment, resulting in increased numbers of circulating endothelial cells (CEC) within the bloodstream. Read More

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http://dx.doi.org/10.2164/jandrol.112.016600DOI Listing
October 2014
8 Reads

Comparison of the results and complications of retroperitoneal, microsurgical subinguinal, and high inguinal approaches in the treatment of varicoceles.

J Androl 2012 Nov-Dec;33(6):1387-93. Epub 2012 Jun 14.

Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan.

The simplicity of the surgical procedure, as well as the high rate of success and low rate of complications, is of particular importance for varicocelectomies. We compared operative parameters, complication rates, and sperm parameters after retroperitoneal, microsurgical subinguinal and high inguinal varicocelectomy approaches in infertile men with varicoceles. This study included 307 infertile men with left varicoceles who underwent varicocelectomy by the retroperitoneal (n = 43), microsurgical subinguinal (n = 107), or high inguinal (n = 157) approach. Read More

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http://dx.doi.org/10.2164/jandrol.112.016444DOI Listing
October 2014
18 Reads

Nandrolone, an anabolic steroid, stabilizes Numb protein through inhibition of mdm2 in C2C12 myoblasts.

J Androl 2012 Nov-Dec;33(6):1216-23. Epub 2012 Jun 14.

National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peter VA Medical Center, Bronx, New York 10468, USA.

Nandrolone, an anabolic steroid, slows denervation atrophy of rat muscle, prevents denervation-induced nuclear accumulation of intracellular domain of the Notch receptor, and elevates expression of Numb. Numb acts as an inhibitor of Notch signaling and promotes myogenic differentiation of satellite cells. Turnover of Numb is regulated by mdm2, an E3 ubiquitin ligase. Read More

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http://dx.doi.org/10.2164/jandrol.112.016428DOI Listing
October 2014
8 Reads

Evaluation of testicular sperm CRISP2 as a potential target for contraception.

J Androl 2012 Nov-Dec;33(6):1360-70. Epub 2012 May 31.

Instituto de Biologia y Medicina Experimental, CONICET, Vuelta de Obligado 2490, Buenos Aires 1428, Argentina.

Cysteine-rich secretory protein 2 (CRISP2) is a testicular sperm protein proposed to be involved in fertilization. With the aim of examining the relevance of CRISP2 for fertility and its potential use as a target for contraception, in the present work, male and female rats were immunized with recombinant CRISP2 coupled to maltose-binding protein (MBP) and evaluated for their subsequent fertility. As controls, animals were injected with either MBP or recombinant CRISP1. Read More

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http://dx.doi.org/10.2164/jandrol.112.016725DOI Listing
October 2014
8 Reads

NADPH oxidase activation: a mechanism of erectile dysfunction in a rat model of sleep apnea.

J Androl 2012 Nov-Dec;33(6):1186-98. Epub 2012 May 31.

Departments of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Erectile dysfunction (ED) is a frequent occurrence in male patients with obstructive sleep apnea syndrome (OSAS). Long-term intermittent hypoxia (LTIH), one of the hallmarks of OSAS, could mediate ED. The objective of this study was to test the hypothesis that increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity contributes to ED in rat responses to LTIH. Read More

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http://dx.doi.org/10.2164/jandrol.112.016642DOI Listing
October 2014
9 Reads

Effect of a 60-day oral gavage of a crude alkaloid extract from Chromolaena odorata leaves on hormonal and spermatogenic indices of male rats.

Authors:
Musa T Yakubu

J Androl 2012 Nov-Dec;33(6):1199-207. Epub 2012 May 31.

Departments of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The present study was aimed at investigating the effects of the crude alkaloids isolated from Chromolaena odorata leaves on the hormonal and spermatogenic indices of male rats. The alkaloids obtained from C odorata leaves using standard methods were administered to male rats for 60 days at the doses of 250, 500, and 1000 mg/kg body weight. Thin-layer chromatographic analysis of the alkaloid mixture produced 8 spots, 3 of which were alkaloids with R(f) values of 0. Read More

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http://doi.wiley.com/10.2164/jandrol.111.016287
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http://dx.doi.org/10.2164/jandrol.111.016287DOI Listing
October 2014
3 Reads

Penile veins are the principal component in erectile rigidity: a study of penile venous stripping on defrosted human cadavers.

J Androl 2012 Nov-Dec;33(6):1176-85. Epub 2012 May 17.

Microsurgical Potency Reconstruction and Research Center, Hsu's Andrology, Taipei, Taiwan.

The human erectile mechanism is an intricate interplay of hormonal, vascular, neurological, sinusoidal, pharmacological, and psychological factors. However, the relative influence of each respective component remains somewhat unclear, and merits further study. We investigated the role of venous outflow in an attempt to isolate the key determinant of erectile function. Read More

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http://dx.doi.org/10.2164/jandrol.112.016865DOI Listing
October 2014
8 Reads

Free nerve ending density on skin extracted by circumcision and its relation to premature ejaculation.

J Androl 2012 Nov-Dec;33(6):1263-7. Epub 2012 May 17.

Department of Urology, Corlu Military Hospital, Corlu, Tekirdag, Turkey.

Many studies have shown that skin tissue extracted by circumcision can cause differences in sexual function, especially at the time of ejaculation. Sensitivity changes in penile skin and sexual satisfaction deriving from circumcision starting from premature ejaculation (PE) are discussed. Furthermore, most of these studies rely on questionnaires. Read More

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http://dx.doi.org/10.2164/jandrol.112.016709DOI Listing
October 2014
12 Reads

A simplified approach to assessing penile endothelial function in young individuals at risk of erectile dysfunction.

J Androl 2012 Nov-Dec;33(6):1254-62. Epub 2012 May 17.

Department of Electrical Engineering, National Dong Hwa University, Hualien, Taiwan.

Erectile dysfunction (ED) reflects a risk for systemic cardiovascular diseases by virtue of a common etiology of vascular endothelial dysfunction, which is increasingly reported to affect young adults. On the basis of physiological phenomenon of reactive hyperemia (RH), systemic and penile endothelial functions in healthy young adults were compared with the use of digital data on arterial waveforms before and after RH induction. Between July 2009 and March 2011, 32 young adult volunteers with normal erectile functions were recruited. Read More

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http://dx.doi.org/10.2164/jandrol.112.016360DOI Listing
October 2014
6 Reads

Association between sex steroid hormones and hematocrit in a nationally representative sample of men.

J Androl 2012 Nov-Dec;33(6):1332-41. Epub 2012 May 17.

Sidney Kimmel Comprehensive Cancer Center and the Department of Epidemiology, Bloomberg School ofPublic Health, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Low or high hematocrit levels are associated with increased morbidity and mortality, mediated via anemia or thromboembolic events, respectively. It is therefore important to identify factors that influence hematocrit. Although androgens are known to stimulate hematopoietic cells, it is unknown whether circulating sex steroid hormones affect hematocrit. Read More

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http://dx.doi.org/10.2164/jandrol.111.015651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774012PMC
October 2014
11 Reads

Erectile dysfunction and extramarital sex induced by timed intercourse: a prospective study of 439 men.

J Androl 2012 Nov-Dec;33(6):1245-53. Epub 2012 May 3.

Department of Andrology, Center for Reproductive Medicine, Zaii Medical Center, Seoul, Korea.

During the fertile window of a woman's menstrual cycle, the effect of impending timed intercourse (TI) on the psychological well-being and behavior of male partners has not been thoroughly investigated, despite the fact that men comprise one half of each couple endeavoring to achieve natural conception. This prospective study consisting of 439 men was conducted during a 3-year period between July 1, 2008, and June 30, 2011. Various characteristics were evaluated, including newly acquired erectile dysfunction (ED); extramarital sex (EMS); intake of soft drinks (SD); levels of hormones, such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin, and estradiol (E2); and semen parameters. Read More

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http://dx.doi.org/10.2164/jandrol.112.016667DOI Listing
October 2014
2 Reads

Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury.

J Androl 2012 Nov-Dec;33(6):1379-86. Epub 2012 May 3.

Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an, China.

Accumulated understanding of epigenetic modifications during ischemia-reperfusion (IR) injury suggests that additional targeted approaches and novel mechanisms that have not been explored in the reproductive system underlie the pathogenesis. Here we show, with a standard murine model of testicular IR, ischemia-induced histone deacetylase (HDAC) activity in the testis with concomitant reduction in histone acetyl transferase activity in vivo. Pretreatment with chemical HDAC inhibitors significantly induced apoptosis in tetraploid pachytene spermatocytes during ischemic insult and thereafter resulted in attenuated meiotic differentiation. Read More

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http://doi.wiley.com/10.2164/jandrol.112.016584
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http://dx.doi.org/10.2164/jandrol.112.016584DOI Listing
October 2014
3 Reads

Monthly variation in acute urinary retention incidence among patients with benign prostatic enlargement in Taiwan.

J Androl 2012 Nov-Dec;33(6):1239-44. Epub 2012 Apr 19.

School of Public Health, Taipei Medical University, Taipei, Taiwan.

Acute urinary retention (AUR) is characterized by a sudden and painful inability to pass urine and is the most common urological emergency. However, according to our knowledge, no study to date has attempted to explore the monthly variation of AUR after adjusting for climatic parameters. This study aimed to examine the monthly variation of AUR due to benign prostatic enlargement (BPE) in Taiwan. Read More

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http://doi.wiley.com/10.2164/jandrol.112.016733
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http://dx.doi.org/10.2164/jandrol.112.016733DOI Listing
October 2014
10 Reads

Perspectives and editorials: letter to the editor.

J Androl 2012 Nov-Dec;33(6):1128-9. Epub 2012 Apr 19.

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http://dx.doi.org/10.2164/jandrol.112.016717DOI Listing
October 2014
16 Reads
2.473 Impact Factor

A unique patient presenting with concomitant Klinefelter syndrome, Alport syndrome, and craniopharyngioma.

J Androl 2012 Nov-Dec;33(6):1155-9. Epub 2012 Apr 19.

Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri IRCCS, University of Pavia, Pavia, Italy.

A 31-year-old Caucasian male was referred for panhypopituitarism resulting from a surgically removed craniopharyngioma. The patient had been previously submitted to kidney transplantation for end-stage renal disease from X-linked Alport syndrome (ATS). Subsequent quantitative fluorescent polymerase chain reaction analysis indicated a 47,XXY karyotype consistent with Klinefelter syndrome (KS). Read More

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http://dx.doi.org/10.2164/jandrol.111.016204DOI Listing
October 2014
12 Reads
2 Citations
2.473 Impact Factor

Semen quality in males with latent genital infections.

Authors:
Andrey Esipov

J Androl 2012 Nov-Dec;33(6):1330; discussion 1331. Epub 2012 Apr 19.

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http://dx.doi.org/10.2164/jandrol.111.015842DOI Listing
October 2014
4 Reads

Luteinizing hormone (LH)-releasing hormone agonist reduces serum adrenal androgen levels in prostate cancer patients: implications for the effect of LH on the adrenal glands.

J Androl 2012 Nov-Dec;33(6):1233-8. Epub 2012 Apr 5.

Department of Urology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Meabashi 371-8511, Japan.

Recently, adrenal androgens have been targeted as key hormones for the development of castration-resistant prostate cancer therapeutics. Although circulating adrenal androgens originate mainly from the adrenal glands, the testes also supply about 10%. Although widely used in androgen deprivation medical castration therapy, the effect of luteinizing hormone-releasing hormone (LH-RH) agonist on adrenal androgens has not been fully studied. Read More

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http://dx.doi.org/10.2164/jandrol.112.016493DOI Listing
October 2014
13 Reads

The high frequency of sperm aneuploidy in klinefelter patients and in nonobstructive azoospermia is due to meiotic errors in euploid spermatocytes.

J Androl 2012 Nov-Dec;33(6):1352-9. Epub 2012 Apr 5.

Laboratoire d'Histologie, Embryologie, Biologie de la Reproduction, Cytogénétique et Génétique Médicale, Hôpital de Poissy St Germain, Poissy, France.

For nonobstructive azoospermic (NOA) patients with a normal karyotype or for Klinefelter syndrome (47,XXY) patients, intracytoplasmic sperm injection is associated with an increased aneuploidy risk in offspring. We examined testicular cells from patients with different azoospermia etiologies to determine the origin of the aneuploid spermatozoa. The incidence of chromosome abnormalities was investigated in all types of azoospermia. Read More

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http://dx.doi.org/10.2164/jandrol.111.016329DOI Listing
October 2014
8 Reads

Low amounts and high thiol oxidation of peroxiredoxins in spermatozoa from infertile men.

J Androl 2012 Nov-Dec;33(6):1342-51. Epub 2012 Apr 5.

Urology Research Laboratory, Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada.

Seminal oxidative stress occurs when there is an increased production of reactive oxygen species (ROS) and/or a decrease of antioxidant activity, promoting impaired sperm function. Peroxiredoxins (PRDX) are abundant in human semen and are important antioxidant enzymes, which act as ROS scavengers and modulators in ROS-dependent signaling. Our aim was to determine whether the levels of PRDX1 and PRDX6 and their oxidation on thiol groups are associated with a decrease in sperm motility and DNA integrity. Read More

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http://dx.doi.org/10.2164/jandrol.111.016162DOI Listing
October 2014
3 Reads

Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats.

J Androl 2012 Nov-Dec;33(6):1169-75. Epub 2012 Apr 5.

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins MedicalInstitutions, Baltimore, Maryland, USA.

Arginase expression and activity have been noted to be heightened in conditions associated with erectile dysfunction, including aging. Previously, arginase inhibition by chronic administration of the arginase inhibitor 2-(S)-amino-6-boronohexanoic acid (ABH) has been shown to improve endothelial dysfunction in aged rats. The objective of this study was to assess whether chronic oral ABH administration affects cavernosal erectile function. Read More

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http://dx.doi.org/10.2164/jandrol.111.015834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029113PMC
October 2014
10 Reads

Acute effects of sildenafil on uroflowmetric parameters in erectile dysfunction patients with and without lower urinary tract symptoms.

J Androl 2012 Nov-Dec;33(6):1165-8. Epub 2012 Apr 5.

Department of Urology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Using phosphodiesterase type 5 (PDE5) inhibitors in patients with lower urinary tract symptoms continues to draw attention. Despite clinical improvements in patients, it is still debatable whether urinary flow rates are increased or not. The aim of this study was to evaluate the acute effects of sildenafil, a PDE5 inhibitor, on uroflowmetry parameters. Read More

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http://dx.doi.org/10.2164/jandrol.111.015776DOI Listing
October 2014
3 Reads

Perspectives and editorials: letter to the editor.

Authors:
Chih-Cheng Lu

J Androl 2012 Nov-Dec;33(6):1127. Epub 2012 Apr 5.

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http://dx.doi.org/10.2164/jandrol.111.015081DOI Listing
October 2014
9 Reads

High-fat diet obesity associated with insulin resistance increases cell proliferation, estrogen receptor, and PI3K proteins in rat ventral prostate.

J Androl 2012 Sep-Oct;33(5):854-65. Epub 2012 Mar 22.

Sector Histology, Institute of Biomedical Sciences, Federal University of Uberlândia-UFU, Uberlândia, Minas Gerais, Brazil

In this study, we evaluated the effects of obesity and insulin resistance induced by a high-fat diet on prostate morphophysiology, focusing on cell proliferation, expression of androgen (AR) and estrogen receptors (ER) and proteins of the insulin signaling pathway. Adult male Wistar rats were fed a high-fat diet (20% fat) for 15 weeks, whereas control animals received a balanced diet (4% fat). Both groups were then divided and treated for 2 weeks with 1 mg/kg body weight/day of the aromatase inhibitor letrozole or vehicle only. Read More

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http://dx.doi.org/10.2164/jandrol.111.016089DOI Listing
March 2013
5 Reads

Methylation-specific PCR allows for fast diagnosis of X chromosome disomy and reveals skewed inactivation of the X chromosome in men with Klinefelter syndrome.

J Androl 2012 Sep-Oct;33(5):955-62. Epub 2012 Mar 22.

Department of Urology, Weill Cornell Medical College, 525 E 68th St, Box 580, New York, NY 10021, USA.

Klinefelter syndrome (KS) remains the most common, yet often undiagnosed, chromosomal aberration in men. Early diagnosis and treatment can improve the health of patients with KS. The aim of this study was to evaluate the inactivation pattern of supernumerary X chromosomes. Read More

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http://dx.doi.org/10.2164/jandrol.111.016030DOI Listing
March 2013
9 Reads

Ion channels in sperm physiology and male fertility and infertility.

J Androl 2012 Sep-Oct;33(5):777-88. Epub 2012 Mar 22.

Division of Endocrinology, Central Drug Research Institute, Lucknow, UP, India.

Ion channels regulate the membrane potential and intracellular ionic concentration and thus serve a central role in various cellular processes. Several ion channels have been identified in the germ cells, including sperm, emphasizing their importance in male fertility and reproduction. The molecular mechanism of ion transport and the nature of the ion channels involved have begun to emerge only recently despite the fact that several ligand-gated and voltage-gated channels have been identified and localized on sperm. Read More

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http://dx.doi.org/10.2164/jandrol.111.015552DOI Listing
March 2013
5 Reads
10 Citations
2.473 Impact Factor

Activity of the Na,K-ATPase α4 isoform is regulated during sperm capacitation to support sperm motility.

J Androl 2012 Sep-Oct;33(5):1047-57. Epub 2012 Mar 22.

Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.

The α4 polypeptide is a testis-specific isoform of the catalytic subunit of the Na,K-ATPase, which is essential for sperm motility and fertility. In the present study, we have investigated the regulation of activity of the α4 isoform and the relevance of this event for sperm capacitation. We have performed this by taking advantage of the selective high affinity of α4 for the inhibitor ouabain. Read More

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http://doi.wiley.com/10.2164/jandrol.111.015545
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http://dx.doi.org/10.2164/jandrol.111.015545DOI Listing
March 2013
6 Reads

Influence of dihydroergotoxine, bromocriptine, and ergotamine on penile erection in Wistar rats.

J Androl 2012 Sep-Oct;33(5):866-71. Epub 2012 Mar 22.

Department of Forensic Medicine, Clinical Centre of Montenegro, 2000 Podgorica, Ljubljanska 1, Montenegro.

The pilot study presented was conducted to determine as to whether ergot alkaloids (alpha-adrenergic blockers) have a potential effect on penile erectile function. The influence of dihydroergotoxine, bromocriptine, and ergotamine was studied on the erection ability in intact, two-grade outbred male Wistar albino rats that were out of their estrous phase. The experimental animals were injected intrapenially with the substances under examination: dihydroergotoxine mesylate (0. Read More

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http://dx.doi.org/10.2164/jandrol.111.015461DOI Listing
March 2013
15 Reads

Quality of sperm obtained by penile vibratory stimulation and percutaneous vasal sperm aspiration in men with spinal cord injury.

J Androl 2012 Sep-Oct;33(5):1036-46. Epub 2012 Mar 22.

Key Laboratory for Improving Birth Outcome Technique, Shandong Provincial Family Planning Institute of Science and Technology, 69 Yuhan Rd Jinan, Jinan City, Shandong 250002, China.

The aim of this study was to explore sperm chromosomal aneuploidy and DNA integrity in infertile patients with spinal cord injury (SCI). Semen samples were collected from 12 infertile men with SCI by percutaneous vasal sperm aspiration (PVSA) and from 14 male SCI patients by penile vibratory stimulation (PVS). These semen samples as well as samples from 16 donors were analyzed using the hypo-osmotic swelling (HOS) test, the sperm chromatin dispersion test, terminal deoxynucleotidyl transferase-mediated terminal uridine nick-end labeling assay, and multicolor fluorescence in situ hybridization with probes specific for the chromosomes 13, 18, 21, X, and Y. Read More

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http://dx.doi.org/10.2164/jandrol.111.014902DOI Listing
March 2013
15 Reads

Pharmacokinetic evaluation and dosing of subcutaneous testosterone pellets.

J Androl 2012 Sep-Oct;33(5):927-37. Epub 2012 Mar 8.

Scott Department of Urology, Baylor College of Medicine, 1709 Dryden St, Suite 1610, Houston, TX 77030, USA.

Subcutaneous testosterone (T) pellets are a viable treatment modality for hypogonadism. Optimal dosing, frequency of reimplantation, and long-term safety of T pellets remain incompletely elucidated parameters. A retrospective review of 273 patients treated for hypogonadism using subcutaneous T pellets was performed. Read More

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http://dx.doi.org/10.2164/jandrol.111.016295DOI Listing
March 2013
7 Reads

Gene therapy with an erythropoietin enhancer-mediated, hypoxia-inducible gene expression system in the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction.

J Androl 2012 Sep-Oct;33(5):845-53. Epub 2012 Mar 8.

Laboratory of Regenerative Sexual Medicine and Department of Urology, Inha University School of Medicine, 7-206, 3rd St, Shinheung-Dong, Jung-Gu, Incheon 400-711, Republic of Korea.

Cavernous hypoxia is an important factor in the pathogenesis of vasculogenic erectile dysfunction (ED). Therefore, the hypoxia-inducible gene expression system can be exploited as gene therapy for vasculogenic ED. This study was undertaken to examine the effectiveness of a hypoxia-inducible gene expression system, namely, the RTP801 promoter or the erythropoietin enhancer, in a mouse model of hypercholesterolemic ED in vivo and in primary cultured mouse cavernous endothelial cells in vitro. Read More

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http://dx.doi.org/10.2164/jandrol.111.016014DOI Listing
March 2013
6 Reads