35 results match your criteria Journal of anaesthesiology clinical pharmacology[Journal]

  • Page 1 of 1

Impact of ondansetron on withdrawal signs, fentanyl requirement and pain relief in opioid addicted patients under general anesthesia.

Curr Clin Pharmacol 2019 Jan 31. Epub 2019 Jan 31.

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman. Iran.

Background: Serotonin 5-HT3 receptor antagonists such as ondansetron have been investigated to attenuate opioid withdrawal signs in studies.

Objective: Therefore, we designed a randomized double-blinded placebo-controlled trial to evaluate this effect in opioid-addicted patients who were admitted to orthopedic department for surgery due to bone fractures.

Method: Male adults who were addicted to opioids, aged 18 to 79 years were enrolled (n=96) and randomized into two oral doses (4 & 8 mg) of ondansetron (n=32) and placebo (n=32). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884714666190131122846DOI Listing
January 2019
1 Read

Drug-Induced Peripheral Neuropathy, a Narrative Review.

Curr Clin Pharmacol 2019 Jan 21. Epub 2019 Jan 21.

Valley Anesthesiology and Pain Consultants, Phoenix, AZ; University of Arizona College of Medicine-Phoenix, Phoenix, AZ; Creighton University School of Medicine, Omaha, NE. United States.

Peripheral neuropathy is a painful condition deriving from many and varied etiologies. Certain medications have been implicated in the iatrogenic development of drug induced peripheral neuropathy (DIPN) and include chemotherapeutic agents, antimicrobials, cardiovascular drugs, psychotropic, anticonvulsants, among others. In many cases, DIPN develops in a dose dependent fashion following continued use of a neurotoxic agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884714666190121154813DOI Listing
January 2019

Correlation between measured and calculated free phenytoin serum concentration in neurointensive care patients with hypoalbuminemia.

Clin Pharmacol 2018 13;10:183-190. Epub 2018 Dec 13.

Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran,

Purpose: In critically ill patients, monitoring free phenytoin concentration is a valuable method for phenytoin-dosage adjustment. However, due to technical difficulties and the high cost of these methods, the Sheiner-Tozer equation is routinely used for estimating free phenytoin concentration in clinical practice. There have been conflicting results concerning accuracy and precision of the Sheiner-Tozer equation for prediction of free phenytoin concentration in various patient populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CPAA.S186322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298392PMC
December 2018
1 Read

Perioperative Management of Hyperlipidemia Medications.

Curr Clin Pharmacol 2017 ;12(3):152-156

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL 32224, United States.

Background: Coronary artery disease is a common comorbidity encountered during the perioperative period. Whether patients are scheduled for cardiac or noncardiac surgery, this cardiovascular disease must be addressed in the preoperative period to decrease the accompanying risks and potential postoperative problems. Lipid-lowering medications are often used to treat hyperlipidemia, a risk factor for the development of atherosclerosis and coronary artery disease. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/156916/article
Publisher Site
http://dx.doi.org/10.2174/1574884712666171108103325DOI Listing
January 2017
22 Reads

Pharmacology and Perioperative Considerations of Pain Medications.

Curr Clin Pharmacol 2017 ;12(3):164-168

Department of Anesthesiology, Columbia University Medical Center, New York, United States.

Background: Pain continues to be the most common medical concern, and perioperative health care providers are encountering increasing numbers of patients with chronic pain conditions. It is important to have a clear understanding of how long-term use of pain medications impacts anesthesia during the intraoperative and postoperative periods.

Objective: To review common medications used to treat chronic pain and summarize current recommendations regarding perioperative care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884712666171027122211DOI Listing
January 2017
34 Reads

Perioperative Pulmonary Medication Management.

Curr Clin Pharmacol 2017 ;12(3):182-187

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL 32224, United States.

Background: Pulmonary conditions such as asthma and chronic obstructive pulmonary disease (COPD) are common conditions that warrant special consideration in the perioperative period. When these patients undergo surgical interventions, they have risk of complications such as bronchospasm, hypoxia, and even postoperative respiratory failure that warrant unplanned intensive care unit admission. Thus, clinicians must be familiar with pulmonary medication regimens that are critical for maintaining stable homeostasis of these chronic conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884712666170918150757DOI Listing
January 2017
32 Reads

Pharmacologic and Perioperative Considerations for Antihypertensive Medications.

Curr Clin Pharmacol 2017 ;12(3):135-140

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL 32224, United States.

Background: As the prevalence of hypertension continues to increase, physicians routinely encounter patients preoperatively receiving one or more cardiovascular medications to manage hypertension. Thus, the physician's knowledge of perioperative antihypertensive medication management is crucial to ensure patient safety.

Objective: We discuss the decisions to continue or stop antihypertensive medications to reduce the risk of perioperative complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884712666170918152004DOI Listing
January 2017
48 Reads

Perioperative Considerations of Herbal Medications.

Curr Clin Pharmacol 2017 ;12(3):194-200

Department of Anesthesiology (Dr Egan), Columbia University Medical Center, New York, NY, United States.

Background: A considerable portion of the US population uses herbal supplements on a daily basis for their various proposed beneficial effects. However, the over-the-counter nature of these medications and lack of knowledge of adverse effect profiles can have unexpected serious impact on the perioperative course. The growing list of supplements presents a pharmacologic conundrum to the anesthesiologist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884712666170913160205DOI Listing
January 2017
19 Reads

Pharmacologic Considerations during the Preoperative Evaluation of Neurologic Patients.

Authors:
Christian Mabry

Curr Clin Pharmacol 2017 ;12(3):176-181

Department of Anesthesiology, Perioperative Care and Pain Medicine, NYU Langone Health, NYU School of Medicine, 550 1st Avenue, New York, NY 10016, United States.

Background: Optimizing a patient for surgery is a central goal during the preoperative period. Patients with common neurologic disorders, such as Alzheimer's disease, epilepsy, Parkinson's disease, and multiple sclerosis may require special attention in the perioperative management of their neurologic medications.

Objective: This review aims to organize the most current recommendations for neurologic medication management during the perioperative period to minimize the risk of postoperative neurologic decline. Read More

View Article

Download full-text PDF

Source
http://www.eurekaselect.com/155242/article
Publisher Site
http://dx.doi.org/10.2174/1574884712666170829115133DOI Listing
January 2017
14 Reads

Pharmacology and Perioperative Considerations for Psychiatric Medications.

Curr Clin Pharmacol 2017 ;12(3):169-175

Department of Anesthesiology & Pain Management, University of Texas Southwestern Medical School, Dallas, TX 75390, United States.

Background: Psychotropic medications are being used increasingly as analgesics and for other off-label indications for patients with and without psychiatric conditions. While the pharmacology of most of these drugs is now known, their interaction with anesthetic drugs and implications of regular use are still relatively unclear.

Objective: We discuss the pharmacology, side effects, and potential medication interactions with anesthetic agents of various commonly prescribed psychotropic medications and the current recommendations regarding the continuation of these medications during the patients' perioperative care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884712666170823121850DOI Listing
January 2017
19 Reads

Pharmacology and Perioperative Considerations for Diabetes Mellitus Medications.

Curr Clin Pharmacol 2017 ;12(3):157-163

Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, United States.

Background: Given the prevalence of diabetes mellitus in modern society, health care providers are frequently tasked with managing glucose control in the perioperative period. When determining perioperative diabetes management, the clinician must balance the need to maintain relative euglycemia at the time of surgery with preventing hypoglycemia or hyperglycemia in a fasting surgical patient. This balance requires an understanding of the pharmacology of these medications, the type of surgery, and the patient's degree of diabetic control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884712666170810115847DOI Listing
January 2017
35 Reads

Clonidine, but not Dexamethasone, Prolongs Ropivacaine-Induced Supraclavicular Brachial Plexus Nerve Block Duration.

Curr Clin Pharmacol 2017 ;12(2):92-98

Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

Background: Ultrasound-guided supraclavicular brachial plexus block (USSB) provides excellent postoperative analgesia after upper extremity surgery. Dexamethasone and clonidine have been added to local anesthetics to enhance and prolong the duration of analgesia.

Objective: The objective of this randomized prospective study is to evaluate the efficacy of dexamethasone, clonidine, or combination of both as adjuvants to ropivacaine on the duration of USSB for postoperative analgesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1574884712666170605085508DOI Listing
January 2017
90 Reads

A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin.

Clin Pharmacol 2016 15;8:203-212. Epub 2016 Dec 15.

Javelin Pharmaceuticals, Cambridge, MA (now Hospira, a Pfizer company, Lake Forest, IL, USA); Department of Anesthesiology, Tufts Medical Center, Boston, MA, USA.

Purpose: The analgesic and opioid-sparing effects of nonsteroidal anti-inflammatory drugs can be beneficial in postoperative populations. Hydroxypropyl-β-cyclodextrin (HPβCD)-diclofenac is an injectable formulation of diclofenac solubilized with HPβCD that is administered as a low-volume intravenous bolus. This open-label, single-dose study examined the effects of age and weight on the pharmacokinetic (PK) profile of HPβCD-diclofenac. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CPAA.S98437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170674PMC
December 2016
18 Reads

In Vivo Measurement in Pigs of Wash-In Kinetics of Xenon at its Site of Action.

Curr Clin Pharmacol 2016 ;11(4):224-229

Department of Anaesthesiology, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

Background: Xenon (Xe) in many respects is an ideal anaesthetic agent. Its blood/gas partition coefficient is lower than that of any other anaesthetic, enabling rapid induction of and emergence from anaesthesia. While the whole body kinetics during wash-in of inhalational anaesthesia is well known, data describing the pharmacokinetics of xenon in the cerebral compartment at the site of action are still largely missing. Read More

View Article

Download full-text PDF

Source
September 2017
41 Reads

Anaesthesia in Cancer Surgery: Can it Affect Cancer Survival?

Authors:
Bruce Ben-David

Curr Clin Pharmacol 2016 ;11(1):4-20

Department of Anesthesiology, UPMC Shadyside Hospital, 5230 Centre Ave, Pittsburgh, PA 15232, USA.

Surgical removal of a tumor may, ironically, unleash prometastatic effects that enhance cancer recurrence and metastatic disease. The patient's physiologic response to the surgical trauma may increase tumor cell growth and invasiveness while diminishing the immune system's ability to eliminate residual disease. At the same time anaesthetic drugs used to accomplish the surgery may also have important effects on cancer cells and the immune system. Read More

View Article

Download full-text PDF

Source
December 2016
5 Reads

Anesthetic pharmacology and perioperative considerations for heart transplantation.

Curr Clin Pharmacol 2015 ;10(1):3-21

Department of Anesthesiology, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

From uncertain beginnings over four decades ago, heart transplantation is now the definitive therapy for end-stage heart failure. This review will attempt to comprehensively cover the broad gamut of anesthetic, hemodynamic, antimicrobial, immunosuppressive and hemostatic agents used by the cardiothoracic anesthesiologist in the perioperative management of patients with endstage heart disease. Read More

View Article

Download full-text PDF

Source
February 2016
7 Reads

Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin - a model-based study.

Clin Pharmacol 2015 5;7:19-27. Epub 2015 Feb 5.

Department of Electrical and Computer Engineering, Division of Systems Engineering, Boston University, Boston, MA, USA.

Purpose: Dabigatran (D) is increasingly used for chronic anticoagulation in place of warfarin (W). These patients may present for catheter-based procedures requiring full anticoagulation with heparin. This study compares the heparin sensitivity of patients previously on dabigatran, on warfarin, or on no chronic anticoagulant during ablation of atrial fibrillation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CPAA.S72185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327399PMC
February 2015
8 Reads

Reducing medication errors in critical care: a multimodal approach.

Clin Pharmacol 2014 1;6:117-26. Epub 2014 Sep 1.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Armstrong Institute for Patient Safety and Quality, Johns Hopkins Medicine, Baltimore, MD, USA.

The Institute of Medicine has reported that medication errors are the single most common type of error in health care, representing 19% of all adverse events, while accounting for over 7,000 deaths annually. The frequency of medication errors in adult intensive care units can be as high as 947 per 1,000 patient-days, with a median of 105.9 per 1,000 patient-days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CPAA.S48530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155993PMC
September 2014
7 Reads

Population pharmacokinetics of olprinone in healthy male volunteers.

Clin Pharmacol 2014 4;6:43-50. Epub 2014 Mar 4.

Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan.

Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III.

Purpose: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers.

Methods: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CPAA.S50626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949558PMC
March 2014
3 Reads

Anesthetic pharmacology for kidney transplantation.

Curr Clin Pharmacol 2015 ;10(1):47-53

Department of Anesthesiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Kidney transplants are routinely performed at medical centers around the world. Concurrent with improved surgical techniques, a better understanding of the pharmacology involved in the perioperative anesthetic management has led to improved outcomes in these patients. This chapter reviews the perioperative pharmacologic considerations surrounding kidney transplant patients from the viewpoint of the transplant anesthesiologist. Read More

View Article

Download full-text PDF

Source
February 2016
10 Reads

Analgesic considerations for liver transplantation patients.

Curr Clin Pharmacol 2015 ;10(1):54-65

Department of Anesthesiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Orthotopic liver transplantation (OLT) recipients have been reported to have decreased perioperative opioid and intraoperative inhalational anesthetic requirements when compared to patients without liver disease undergoing other types of major abdominal surgeries. The severity of the liver disease and the process of the transplantation itself may alter the pharmacokinetic and pharmacodynamic effects of different pain medications. Chemical injury of the liver and the high degree of surgical stress may also increase the levels of neuropeptides involved in pain modulation. Read More

View Article

Download full-text PDF

Source
February 2016
10 Reads

Lung transplantation: perioperative pharmacology and anesthetic considerations.

Curr Clin Pharmacol 2015 ;10(1):22-34

Department of Anesthesiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.

In the past two decades, lung transplantation has become an increasingly important surgical option for the patient with end stage lung disease. Compared with the other solid organ transplants (heart, liver and kidney), lung transplantation carries immense clinical and logistic challenges; long-term organ viability is particularly problematic, with an expected five-year mortality of 40-50%. The number of lung transplants performed in the U. Read More

View Article

Download full-text PDF

Source
February 2016
4 Reads

Anesthetic pharmacology and perioperative considerations for the end stage liver disease patient.

Curr Clin Pharmacol 2015 ;10(1):35-46

Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

The number of patients with end stage liver disease is growing worldwide. This is likely a result of advances in medical science that have allowed these patients to lead longer lives since the incidence of diseases such as alcoholic cirrhosis and viral hepatitis have remained stable or even decreased in recent years, at least in more developed nations. Many of these patients will require anesthetic care at some point. Read More

View Article

Download full-text PDF

Source
February 2016
13 Reads

The effect of adult and pediatric cardiopulmonary bypass on pharmacokinetic and pharmacodynamic parameters.

Curr Clin Pharmacol 2013 Nov;8(4):297-318

Department of Cardio-Thoracic Anesthesiology, Room Bd-579, 's Gravendijkwal 230, 3015 CE, Erasmus MC, Rotterdam, The Netherlands.

Cardiopulmonary bypass (CPB) is known to have important effects on the disposition of drugs, which in turn may have important implications for the efficacy and toxicity of drug therapy. These effects constantly change throughout CPB and some continue to exert influence after the patient has been successfully weaned. In children, developmental and disease specific changes in drug disposition and effect also need to be taken into account when studying the effects of CPB. Read More

View Article

Download full-text PDF

Source
November 2013
9 Reads

The concept of titration can be transposed to fluid management. but does is change the volumes? randomised trial on pleth variability index during fast-track colonic surgery.

Curr Clin Pharmacol 2013 May;8(2):110-4

Department of Anesthesiology, Cliniques UniversitairesSaint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Background: The concept of drug titration emerged recently for intraoperative fluid administration during Fast-Track colonic surgery to avoid hypovolemia as well as excessive crystalloid administration. The Pleth Variability Index (PVI) is an oximeter-derived parameter. It allows a continuous monitoring of the respiratory variation of the perfusion index. Read More

View Article

Download full-text PDF

Source
May 2013
5 Reads

Continuous infusion of antibiotics in critically ill patients.

Curr Clin Pharmacol 2013 Feb;8(1):13-24

Department of Anaesthesiology, Intensive Therapy and Pain Management, University Hospital, Przybyszewskiego 49, Poznan, Poland.

Antibiotics are the most commonly used drugs in intensive care unit patients and their supply should be based on pharmacokinetic/pharmacodynamic rules. The changes that occur in septic patients who are critically ill may be responsible for subtherapeutic antibiotic concentrations leading to poorer clinical outcomes. Evolving in time the disturbed pathophysiology in severe sepsis (high cardiac output, glomerular hyperfiltration) and therapeutic interventions (e. Read More

View Article

Download full-text PDF

Source
https://www.uclouvain.be/cps/ucl/doc/ir-ldri/images/Vanheren
Web Search
February 2013
7 Reads

Pharmacogenetics and anesthetic drugs.

Curr Clin Pharmacol 2012 May;7(2):78-101

Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

The incidence and potential for serious adverse drug reactions (SADRs) in anesthesia are high due to the narrow therapeutic indices of anesthetic and analgesic drugs and high interindividual variability in drug responses. Genetic factors contribute to a majority of these SADRs. Pharmacogenetics (PG), the study of genetic effects on drug action, is strongly related to the field of anesthesia; historically, succinylcholine apnea and malignant hyperthermia were among the first PG disorders reported. Read More

View Article

Download full-text PDF

Source
May 2012
5 Reads

Targeting Spinal Long-Term Potentiation as a Basis for Analgesia Recent Developments.

Curr Clin Pharmacol 2012 Jan 25. Epub 2012 Jan 25.

University Hospital of Ulm, Department of Anesthesiology, Steinhoevelstrasse 9 D-89075 Ulm, Germany.

Recent investigations of pain mechanisms leading to the induction and maintenance of long-term potentiation (LTP) in the spinal cord have identified a huge number of molecular targets that might be appropriate for therapeutically intervention. In this short review we summarize recently published studies investigating drugs that affect LTP in the spinal cord. After providing an overview of spinal pain pathways and of the respective methods for their investigation, molecular targets for possible pharmacological interventions are discussed. Read More

View Article

Download full-text PDF

Source
January 2012
3 Reads

Targeting spinal long-term potentiation as a basis for anlagesia: recent developments.

Curr Clin Pharmacol 2012 Feb;7(1):1-6

University Hospital of Ulm, Department of Anesthesiology, Ulm, Germany.

Recent investigations of pain mechanisms leading to the induction and maintenance of long-term potentiation (LTP) in the spinal cord have identified a huge number of molecular targets that might be appropriate for therapeutically intervention. In this short review we summarize recently published studies investigating drugs that affect LTP in the spinal cord. After providing an overview of spinal pain pathways and of the respective methods for their investigation, molecular targets for possible pharmacological interventions are discussed. Read More

View Article

Download full-text PDF

Source
February 2012
39 Reads

Drug-induced anemia and other red cell disorders: a guide in the age of polypharmacy.

Curr Clin Pharmacol 2011 Nov;6(4):295-303

Department of Anesthesiology and Critical Care Medicine, Englewood Hospital and Medical Center, NJ 07631, USA.

Several medications have been linked to red blood cell (RBC) disorders. The frequency of these side effects varies, depending on the condition, but they can be associated with significant morbidity and mortality. The problem is likely to exacerbate in aging populations with frequent comorbidities, proportional to the growing number of medications used. Read More

View Article

Download full-text PDF

Source
November 2011
3 Reads

Pretreatment by hyperoxia--a tool to reduce ischaemia-reperfusion injury in the myocardium.

Curr Clin Pharmacol 2010 May;5(2):125-32

Clinic of Anaesthesiology, North Estonia Medical Centre, Sütiste 19, Tallinn 13419, Estonia.

Atherosclerosis leads to narrowing and occlusion of coronary arteries, resulting in inadequate oxygen supply for maintenance of normal oxidative metabolism. To avoid profound ischaemia and subsequent necrosis of cardiomyocytes, blood flow has to be restored by means of thrombolysis, percutaneous coronary intervention, or surgical revascularisation. Besides restoring oxygen supply to the cells, introduction of molecular oxygen to the ischaemic tissue results in a spectrum of unfavourable events, termed altogether as reperfusion injury. Read More

View Article

Download full-text PDF

Source
May 2010
5 Reads

Analgesic efficacy of oral gabapentin added to standard epidural corticosteroids in patients with failed back surgery.

Authors:
Beyazit Zencirci

Clin Pharmacol 2010 30;2:207-11. Epub 2010 Sep 30.

Department of Anesthesiology and Reanimation, Medical Faculty of Sutcu Imam University, Kahramanmaras, Turkey.

Objective: Failed back surgery syndrome is characterized by the presence of intractable pain and varying degrees of functional incapacity after lumbar spine surgery. Because the mechanisms that cause pain are variable, treatment of this syndrome is quite difficult, and one of the most common methods that is used for treatment nowadays is epidural injection. This research evaluates the analgesic efficacy of addition of oral gabapentin treatment to epidural corticosteroid application in patients with failed back surgery syndromes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CPAA.S12126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262382PMC
June 2012
4 Reads

Lidocaine 5% patch for localized neuropathic pain: progress for the patient, a new approach for the physician.

Clin Pharmacol 2010 30;2:65-70. Epub 2010 Mar 30.

Department of Anesthesiology, Antwerp University Hospital, Edegem, Belgium.

Neuropathic pain (NeP) syndromes remain a difficult-to-treat medical entity. Despite a growing number of pharmacological and invasive analgesic therapies the results remain less than optimal because of insufficient analgesic efficacy and/or occurrence of pronounced side effects. Current guidelines propose the use of multimodal and balanced pharmacological therapies, focused on the underlying pathophysiological mechanisms (mechanistic approach). Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262358PMC
http://dx.doi.org/10.2147/CPAA.S9795DOI Listing
June 2012
10 Reads

Effect of buspirone on thermal sensory and pain thresholds in human volunteers.

BMC Clin Pharmacol 2009 May 29;9:12. Epub 2009 May 29.

Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen Medical School, Göttingen, Germany.

Background: Buspirone is a partial 5-HT1A receptor agonist. Animal studies have shown that modulation of serotoninergic transmission at the 5-HT1A receptor can induce analgesia in acute pain models. However, no studies have been published so far on the effects of serotonin receptor agonists on pain perception in humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1472-6904-9-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698897PMC
May 2009
17 Reads

Methanol poisoning and long term sequelae - a six years follow-up after a large methanol outbreak.

BMC Clin Pharmacol 2009 Mar 27;9. Epub 2009 Mar 27.

Department of Anesthesiology and ICU, Foundation Pärnu Hospital, Pärnu, Estonia.

Background: Mass poisonings with methanol are rare but occur regularly both in developed and in developing countries. Data from the poisoning episodes are often published, but follow-up-data is scarce. We therefore conducted a six year follow-up study after the large methanol outbreak in Estonia in September 2001. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1472-6904-9-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667428PMC
March 2009
4 Reads
  • Page 1 of 1