10,291 results match your criteria Journal of affective disorders[Journal]


Subtypes of treatment-resistant depression determined by a latent class analysis in a Chinese clinical population.

J Affect Disord 2019 Feb 6;249:82-89. Epub 2019 Feb 6.

Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, China; Shanghai Key Laboratory of Psychotic Disorders, 600 South Wan Ping Road, Shanghai, China; CAS Center for Excellence in Brain Science and Intelligence Technology, 600 South Wan Ping Road, Shanghai, China. Electronic address:

Background: This study aimed to explore subtypes of treatment-resistant depression (TRD).

Methods: Latent class analysis (LCA) was performed on clinical and demographic data collected from 375 patients with TRD. Clinical variables were compared across subtypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183258
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http://dx.doi.org/10.1016/j.jad.2019.02.005DOI Listing
February 2019
1 Read

The associations between subjective and objective cognitive functioning across manic or hypomanic, depressed, and euthymic states in Chinese bipolar patients.

J Affect Disord 2019 Feb 6;249:73-81. Epub 2019 Feb 6.

School of Nursing, Sun Yat-sen University, Guangzhou 510078, China.

Background: Patients may present cognitive deficits during all stages of bipolar disorder (BD). Few studies have examined self-reported cognitive difficulties and its relation to neurocognitive dysfunction during symptomatic periods of BD. This study aimed to compare subjective cognitive functioning and explore associations between subjective and objective cognitive functioning across different BD clinical states, and investigate the predicting and moderating roles of mood symptoms. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.025DOI Listing
February 2019

Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder.

J Affect Disord 2019 Feb 6;249:63-72. Epub 2019 Feb 6.

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland; Department of Psychiatry, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Psychiatry, Länsi-Pohja Healthcare District; Department of Psychiatry, the Middle Ostrobothnia Central Hospital, Soite; Mental Health Services, Joint Municipal Authority of Wellbeing in Raahe District; Mental Health Services and Basic Health Care District of Kallio; and Department of Psychiatry, Kainuu Central Hospital, Kainuu Social and Healthcare District, Finland.

Background: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders.

Methods: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.011DOI Listing
February 2019

Longitudinal course of cognitive function across treatment in patients with MDD: A meta-analysis.

J Affect Disord 2019 Feb 6;249:52-62. Epub 2019 Feb 6.

Department of Clinical Psychology and Psychotherapy, University of Koblenz-Landau, Ostbahnstraße 10, Landau 76829, Germany.

Background: The longitudinal change of cognitive function across psychological treatment remains unclear. The aim of this meta-analysis was to synthesize results from longitudinal studies of cognitive deficits in MDD patients across treatment to examine change and determine domains that are most sensitive to change.

Methods: A literature search was conducted using PsycINFO, MEDLINE, Science direct, and Google scholar databases. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.021DOI Listing
February 2019

Corrigendum to "Identifying cognitive subgroups in bipolar disorder: A cluster analysis" [Journal of Affective Disorders 246C (2019) 252-261].

J Affect Disord 2019 Feb 8. Epub 2019 Feb 8.

Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Postgraduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate Program of Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul (UFRGS). Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.02.001DOI Listing
February 2019

Cross-sectional associations between long-term exposure to particulate matter and depression in China: The mediating effects of sunlight, physical activity, and neighborly reciprocity.

J Affect Disord 2019 Feb 6;249:8-14. Epub 2019 Feb 6.

Department of Human Geography and Spatial Planning, Utrecht University, The Netherlands. Electronic address:

Background: Although numerous studies have speculated about the direct and indirect linkage between long-term air pollution (i.e., PM) concentrations and mental health in developed countries, evidence for developing countries is limited. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.007DOI Listing
February 2019

Investigation of the emotional network in depression after stroke: A study of multivariate Granger causality analysis of fMRI data.

J Affect Disord 2019 Feb 6;249:35-44. Epub 2019 Feb 6.

Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. Electronic address:

Objective: Depression after stroke (DAS) is a serious complication of stroke that significantly restricts rehabilitation. Brain imaging technology is an important method for studying the emotional network of DAS. However, few studies have focused on dynamic interactions within the network. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.020DOI Listing
February 2019

Resting-state functional connectivity and inflexibility of daily emotions in major depression.

J Affect Disord 2019 Feb 6;249:26-34. Epub 2019 Feb 6.

Department of Psychology, Stanford University, Building 420, Jordan Hall, Stanford, CA, USA.

Background: Major Depressive Disorder (MDD) is characterized by aberrant resting-state functional connectivity (FC) in anterior cingulate regions (e.g., subgenual anterior cingulate [sgACC]) and by negative emotional functioning that is inflexible or resistant to change. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.040DOI Listing
February 2019

The co-occurrence of diabetes and adverse childhood experiences and its impact on mortality in US adults.

J Affect Disord 2019 Feb 6;249:20-25. Epub 2019 Feb 6.

Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA; Center for Advancing Population Science (CAPS), Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; University of Wisconsin, Milwaukee, Joseph Zilber School of Public Health, 1240 N 10th Street Milwaukee, WI 53205, USA. Electronic address:

Background: Diabetes is a leading cause of death in the US. Adverse childhood experiences (ACEs) have also been linked to increased mortality. ACEs are associated with the development of diabetes however the amplified effect on mortality has not been studied. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.016DOI Listing
February 2019

Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review.

J Affect Disord 2019 Feb 6;249:15-19. Epub 2019 Feb 6.

Mood Disorders Program, Tufts Medical Center, Boston, MA, USA; Department of Psychiatry, Tufts University Medical School, Boston, MA, USA. Electronic address:

Background: Apparent comorbidity between bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is a common condition in psychiatry, but treatment of BD-OCD remains a clinical challenge. Although serotonin reuptake inhibitors (SRIs) are the first line treatment for OCD, they can induce mood instability in BD. An optimal treatment approach remains to be defined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183291
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http://dx.doi.org/10.1016/j.jad.2019.02.024DOI Listing
February 2019
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Risk of autistic spectrum disorder in offspring with parental mood disorders: A systematic review and meta-analysis.

J Affect Disord 2019 Feb 1;248:185-197. Epub 2019 Feb 1.

School of Social Sciences, The University of Queensland, 80 Meiers Rd, Indooroopilly, Queensland 4068Australia; School of public Heath, Curtin University, Western Australia, Australia. Electronic address:

Background: The association between mood disorders in parents and autism spectrum disorder (ASD) risk in offspring has been investigated in several studies, but the evidence is inconclusive. This systematic review and meta-analysis will explore whether an association exists between parental mood disorders and ASD risk in offspring.

Methods: A literature search was performed using the electronic databases PubMed, EMBASE, PsycINFO, and Scopus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183097
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http://dx.doi.org/10.1016/j.jad.2019.01.038DOI Listing
February 2019
6 Reads

Low affective temperament consistency during development: Results from a large retrospective study.

J Affect Disord 2019 Jan 28;248:180-184. Epub 2019 Jan 28.

School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Av. Ipiranga 6681, Pd 12A, Porto Alegre, RS 90619-900, Brazil; Medical School, University of Vale do Taquari, Av. Avelino Talini, 171, Pd 22, Lajeado, RS 95900-000, Brazil. Electronic address:

Background: Temperament is still regarded as a stable part of personality, an "endophenotype" developed early in life. However, how frequently temperament traits can change throughout life is not clear. The aim of this study was to investigate affective temperament changes from late childhood to adolescence and from late adolescence to adulthood. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.034DOI Listing
January 2019
1 Read

Correlates for state and trait anxiety in a multicultural sample of Turkish and Spanish women at first trimester of pregnancy.

J Affect Disord 2019 Jan 31;249:1-7. Epub 2019 Jan 31.

Obstetrics and Gynaecology Clinic, Sisli, Istanbul.

Objective: The main objective of this research was to assess the potential influence of cultural factors on the anxiety levels of a multicultural sample of Spanish and Turkish pregnant women at the beginning of the pregnancy.

Methods: Between October and December 2017 a total of 250 Turkish and 264 Spanish pregnant women attending their first pregnancy medical check-up between 10 and 12 weeks of pregnancy in three different cities, Istanbul, Antalya and Malaga, were recruited for study. These women completed a questionnaire that included the Turkish or Spanish validated of the state-trait anxiety Inventory, and a series of questions related to health status, general mood, and sociodemographic variables. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.036DOI Listing
January 2019
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Study of 45 candidate genes suggests CACNG2 may be associated with lithium response in bipolar disorder.

J Affect Disord 2019 Jan 15;248:175-179. Epub 2019 Jan 15.

Department of Psychiatry, University of California San Diego, La Jolla 92093 CA, USA; Department of Psychiatry, VA San Diego Healthcare System, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

Background: Bipolar disorder is a neuropsychiatric disorder that is characterized by fluctuations between manic and depressive phases. Lithium is the original and best mood stabilizing treatment for bipolar disorder. While its mechanism is not well understood, it is believed to have a strong genetic component, as several studies suggest that lithium responsiveness, in bipolar disorder, is heritable. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.010DOI Listing
January 2019
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Reduced gamma-amino butyric acid (GABA) and glutamine in the anterior cingulate cortex (ACC) of veterans exposed to trauma.

J Affect Disord 2019 Jan 31;248:166-174. Epub 2019 Jan 31.

Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA; Diagnostic Neuroimaging, University of Utah, Salt Lake City, UT, USA; George E. Wahlen Department of Veterans Affairs Medical Center, VA VISN 19 Mental Illness Research, Education and Clinical Center (MIRECC), Salt Lake City, UT, USA. Electronic address:

Background: Trauma-related diagnoses such as posttraumatic stress disorder (PTSD) are prevalent in veterans. The identification of mechanisms related to stress vulnerability and development of PTSD specifically in a veteran population may aid in the prevention of PTSD and identification of novel treatment targets.

Methods: Veterans with PTSD (n = 27), trauma-exposed veterans with no PTSD (TEC, n = 18) and non-trauma-exposed controls (NTEC, n = 28) underwent single-voxel proton (H) magnetic resonance spectroscopy (MRS) at 3 Tesla in the dorsal anterior cingulate cortex (dACC) using a two-dimensional (2D) J-resolved point spectroscopy sequence in addition to completing a clinical battery. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.037DOI Listing
January 2019
3 Reads

Insomnia late in pregnancy is associated with perinatal anxiety: A longitudinal cohort study.

J Affect Disord 2019 Jan 28;248:155-165. Epub 2019 Jan 28.

HØKH, Research Unit, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway; Department for Infant Mental Health, Regional Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway.

Background: Postpartum anxiety (PPA) affects a substantial number of women. Despite increasing recognition of PPA, few studies have focused on perinatal anxiety and potential PPA triggers. Here we aimed to estimate the prevalence of perinatal anxiety disorders, and to explore the association between insomnia during late pregnancy and anxiety before and after childbirth. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.027DOI Listing
January 2019
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Vegetarian diet and mental health: Cross-sectional and longitudinal analyses in culturally diverse samples.

J Affect Disord 2019 Jan 29;248:147-154. Epub 2019 Jan 29.

Ruhr-Universität Bochum, Clinical Child and Adolescent Psychology, Bochum, Germany. Electronic address:

Background: Vegetarianism is linked with better physical health, but also to increased anxiety and depression. The aim of the present study is to examine the relationship between vegetarianism and both positive and negative mental health, across cultures and over time.

Method: Self-report questionnaire data were obtained from a large-scale multi-national cross-sectional sample including 2007 representative adult members of the German population, 3020 representative adults from Russia, and 3038 representative adults from the USA. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.035DOI Listing
January 2019
8 Reads

Different trajectories of depressive symptoms during pregnancy.

J Affect Disord 2019 Jan 26;248:139-146. Epub 2019 Jan 26.

Department of Medical and Clinical Psychology, Tilburg University, Warandelaan 2, 5037 AB, PO Box 90153, 5000 LE Tilburg, The Netherlands.

Background: Up to 10-15% of women experience high levels of depressive symptoms during pregnancy. Since these levels of symptoms can vary greatly over time, the current study investigated the existence of possible longitudinal trajectories of depressive symptoms during pregnancy, and aimed to identify factors associated with these trajectories.

Methods: Depressive symptoms were assessed prospectively at each trimester in 1832 women, using the Edinburgh (Postnatal) Depression Scale (E(P)DS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183219
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http://dx.doi.org/10.1016/j.jad.2019.01.021DOI Listing
January 2019
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Association between mood disorders and BMI/overweight using a family study approach.

J Affect Disord 2019 Jan 15;248:131-138. Epub 2019 Jan 15.

Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, 35 Convent Drive, MSC 3720, Bldg 35A, Room 2E422A, Bethesda, MD, USA.

Background: We previously demonstrated the specificity of familial transmission of the atypical subtype of depression, primarily characterized by overeating and oversleeping. However, the specific components of this subtype that are familial have not been established. The aim of this paper is to examine whether the familial specificity of atypical depression can be attributed to the association between Body Mass Index (BMI) and overweight/obesity with mood disorders. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.011DOI Listing
January 2019

'What people diagnosed with bipolar disorder experience as distressing': A meta-synthesis of qualitative research.

J Affect Disord 2019 Jan 29;248:108-130. Epub 2019 Jan 29.

School of Health Sciences, Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester. 2nd Floor, Zochonis Building, Brunswick Street, Manchester, M13 9PL, UK.

Background: Bipolar disorder (BD) is considered to have a significantly negative impact on functioning and prognosis is considered poor. Current treatments are modestly effective and predominantly focus on reducing extreme mood fluctuations and symptoms, yet less is known about what patients themselves describe as distressing. Therefore we aimed to assess this through a systematic review. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.024DOI Listing
January 2019
2 Reads

Physical injury and depression in six low- and middle-income countries: A nationally representative study.

J Affect Disord 2019 Jan 28;248:99-107. Epub 2019 Jan 28.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5 Pabellón 11, Madrid 28029, Spain.

Background: Studies on the association between physical injury and depression in low- and middle-income countries (LMICs) are scarce. Therefore, our goal was to analyze the association between physical injury and depression using nationally representative data from six LMICs.

Methods: Cross-sectional data from the Study on Global Ageing and Adult Health (SAGE) survey (2007-2010) were analyzed (N = 42,489). Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.023DOI Listing
January 2019
1 Read

The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling pathway in hippocampus.

J Affect Disord 2019 Jan 28;248:81-90. Epub 2019 Jan 28.

Department of Neurology, Zhongnan Hospital, Wuhan University, No.169, Donghu Road, Wuhan, Hubei 430071, China. Electronic address:

Background: Chronic unpredictable mild stress (CUMS) is an important risk factor for depression and cognitive deficits in humans. Enriched environment (EE) showed a beneficial effect on depression and cognition by enhancing brain derived neurotrophic factor (BDNF) expression and synaptic plasticity. However, it is still not clearly understood whether an epigenetic mechanism is involved in the BDNF modulation and synaptic plasticity that occurs after EE treatment for the depressive-like behaviors and cognitive deficits elicited by CUMS. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.031DOI Listing
January 2019
2 Reads

Intergenerational relationship, family social support, and depression among Chinese elderly: A structural equation modeling analysis.

J Affect Disord 2019 Jan 28;248:73-80. Epub 2019 Jan 28.

School of Social and Behavioral Sciences, Nanjing University, Nanjing, China.

Objective: This study aimed to investigate the association among intergenerational relationship, family social support, and elderly's depression symptoms.

Method: Data were obtained from China Longitudinal Aging Social Survey (CLASS) 2014, which is a continuous large-scale national social survey project conducted by the National Survey Research Center at Renmin University of China. Stratified multi-stage probability sampling method was used to collect the sample (N = 11,511). Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.032DOI Listing
January 2019

Is social network site usage related to depression? A meta-analysis of Facebook-depression relations.

J Affect Disord 2019 Jan 27;248:65-72. Epub 2019 Jan 27.

Department of Psychology, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620, USA.

Background: Facebook depression is defined as feeling depressed upon too much exposure to Social networking sites (SNS). Researchers have argued that upward social comparisons made on SNS are the key to the Facebook depression phenomenon. To examine the relations between SNS usage and depression, we conducted 4 separate meta-analyses relating depression to: (1) time spent on SNS, (2) SNS checking frequency, (3) general and (4) upward social comparisons on SNS. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.026DOI Listing
January 2019
3.383 Impact Factor

Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake.

J Affect Disord 2019 Jan 28;248:52-58. Epub 2019 Jan 28.

CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China.

Background: Many studies have shown that the disturbance of pro-inflammatory and/or anti-inflammatory cytokines is involved in the modulation of traumatic stress and related psychiatric disorders, typically posttraumatic stress disorder (PTSD). However, the specific immune alterations associated with PTSD symptoms are still unclear. The present study compared levels of pro- and anti-inflammatory cytokines between PTSD and non-PTSD controls, and investigated the relationships of immune changes with PTSD symptomatology. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183249
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http://dx.doi.org/10.1016/j.jad.2019.01.029DOI Listing
January 2019
3 Reads
3.383 Impact Factor

Feasibility of a group-based laughter yoga intervention as an adjunctive treatment for residual symptoms of depression, anxiety and stress in people with depression.

J Affect Disord 2019 Jan 28;248:42-51. Epub 2019 Jan 28.

Nethersole School of Nursing, Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Laughter Yoga (LY) is a group-based intervention involving simulated laughter, gentle stretching, rhythmic breathing and meditation. There is some limited evidence that LY reduces depressive symptoms over the short term. However, the quality of previous LY studies is poor and none involved working-aged people with a clinical diagnosis of depression. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.030DOI Listing
January 2019
1 Read

On a continuum to anxiety disorders: Adolescents at parental risk for anxiety show smaller rostral anterior cingulate cortex and insula thickness.

J Affect Disord 2019 Jan 28;248:34-41. Epub 2019 Jan 28.

Research Center, Sainte-Justine Hospital, University of Montreal, 3175 Côte Ste-Catherine, Montréal, Québec H3T 1C5, Canada; Research Center in Neuropsychology and Cognition, University of Montreal, Canada; Department of Psychiatry, University of Montreal, Canada.

Background: Having a parent with an anxiety disorder increases the risk of anxiety symptoms and anxiety disorders during the lifespan. Moreover, childhood and adolescence anxiety disorders and symptoms have been linked to a range of brain structure abnormalities. However, to date, no study has investigated brain anatomy in adolescents at high risk based on parental anxiety disorders and in adolescents with an anxiety disorder but without any treatment or therapy. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.028DOI Listing
January 2019
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Examining differential relationships among self-reported attentional control, depression, and anxiety in a transdiagnostic clinical sample.

J Affect Disord 2019 Jan 16;248:29-33. Epub 2019 Jan 16.

Behavioral Health Partial Hospital Program, McLean Hospital, Belmont, MA, United States; Department of Psychiatry, Harvard Medical School, Cambridge, MA, United States.

Background: Poor attentional control, defined as difficulty focusing attention on a task or shifting attention flexibly between tasks, is a transdiagnostic construct theorized to confer risk for, and maintain, depression and anxiety. Research to date in non-clinical samples has suggested a dissociable relationship between the two factors of self-reported attentional control and psychopathology, with depression being associated with difficulties shifting and anxiety being associated with focusing. However, to our knowledge no study has tested this differential set of relationships in a clinical sample. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.017DOI Listing
January 2019
2 Reads

FKBP5 gene variants and borderline personality disorder.

J Affect Disord 2019 Jan 27;248:26-28. Epub 2019 Jan 27.

INSERM UMRS1266, Institute of Psychiatry and Neuroscience of Paris, France; Sainte-Anne hospital (Paris-Descartes university), Paris, France.

Background: Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD).

Methods: In this study, five FKBP5 (a co-chaperone of the glucocorticoid receptor) SNPs (rs3800373, rs9296158, rs737054, rs1360780, rs9470080) were genotyped in a sample of 101 unrelated Caucasian patients with BPD and 111 ethnically matched healthy controls. The interaction between FKBP5 polymorphisms and childhood trauma was also tested. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.025DOI Listing
January 2019
3 Reads

Breastfeeding reduces risk of depression later in life in the postmenopausal period: A Korean population-based study.

J Affect Disord 2018 Dec 25;248:13-17. Epub 2018 Dec 25.

Department of Health Convergence, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea. Electronic address:

Objective: The relationship between breastfeeding and maternal depression in later life has not yet been investigated. We examined whether the number of breastfed infants or the period of breastfeeding influenced maternal depression in postmenopausal women.

Methods: We analyzed 1,372 parous postmenopausal women aged ≥ 50 years who had participated in the Korea National Health and Nutrition Examination Survey 2014. Read More

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http://dx.doi.org/10.1016/j.jad.2018.12.081DOI Listing
December 2018

Unmet health care needs in old age and their association with depression - results of a population-representative survey.

J Affect Disord 2019 02 19;245:998-1006. Epub 2018 Nov 19.

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, Leipzig 04103, Germany.

Background: Due to the demographic changes, unmet health care needs are expected to increase in the elderly population. The aim of this study was to analyse the distribution of met and unmet needs and their association with depression in old age.

Methods: Based on a population-representative telephone survey of the elderly population aged 75 + years and older, a sample of 845 individuals was assessed via structured clinical interviews. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.096DOI Listing
February 2019

Acute effects of aerobic exercise on negative affect and obsessions and compulsions in individuals with obsessive-compulsive disorder.

J Affect Disord 2019 02 14;245:991-997. Epub 2018 Nov 14.

University of Rhode Island, Department of Kinesiology, Kingston, RI USA.

Background: The acute effects of aerobic exercise on improved mood and anxiety reduction have been demonstrated across clinical and nonclinical populations. Limited work has evaluated the acute effects of aerobic exercise on negative affect, obsessions, and compulsions in patients with Obsessive Compulsive Disorder (OCD).

Method: Fifty-five patients (64% female) with treatment-resistant OCD were randomized to either 12 weeks of aerobic exercise (AE) or health education contact (HEC) control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183164
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http://dx.doi.org/10.1016/j.jad.2018.11.074DOI Listing
February 2019
7 Reads

Exploration of the psychometric properties of the 33-item Hypomania Checklist - external assessment (HCL-33-EA).

J Affect Disord 2019 02 5;245:987-990. Epub 2018 Nov 5.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, P.O. Box 1931, Zurich 8032, Switzerland.

Background: Misdiagnosis of bipolar disorder (BD) is common in clinical practice, leading to inappropriate treatment and detrimental consequences. The 33-item Hypomania Checklist (HCL-33) is a newly developed screening instrument for hypomanic symptoms in patients with BD. The 33-item Hypomania Checklist-external assessment (HCL-33-EA) is a version of the HCL-33 for carers of patients with mood disorders. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.023DOI Listing
February 2019
1 Read

Altered white matter volumes in first-episode depression: Evidence from cross-sectional and longitudinal voxel-based analyses.

J Affect Disord 2019 02 13;245:971-977. Epub 2018 Nov 13.

Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona (UAB), Spain.

Background: Major depressive disorder (MDD) is accompanied by atypical brain structure affecting grey and white matter from the early stages. Neuroimaging studies of first-episode depression (FED) have provided evidence on this regard, but most of the studies are cross-sectional. The aim of this longitudinal study was to test potential changes in grey matter (GM) and white matter (WM) volumes in FED. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183148
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http://dx.doi.org/10.1016/j.jad.2018.11.085DOI Listing
February 2019
3 Reads

Course of a major postpartum depressive episode: A prospective 2 years naturalistic follow-up study.

J Affect Disord 2019 02 5;245:965-970. Epub 2018 Nov 5.

Unitat de Salut Mental Perinatal CLINIC-BCN, Hospital Clínic, Barcelona, Spain; Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:

Background: Survival methodology has not already been used in studies about postpartum depression (PPD) course. The aims of the present study were to estimate the duration of a Major Postpartum Depressive Episode (MPDE) during 2 years, as well as to explore factors associated with the course.

Method: This was a prospective, naturalistic, longitudinal study with a cohort of 165 women with a MPDE (DSM-IV criteria). Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.062DOI Listing
February 2019

Double-blind, placebo-controlled trial of pioglitazone for bipolar depression.

J Affect Disord 2019 02 13;245:957-964. Epub 2018 Nov 13.

Department of Psychiatry, Mood Disorders Program, University Hospitals Cleveland Medical Center/Case Western Reserve University, 10524 Euclid Avenue, 12th Floor, Cleveland, OH, 44106, United States. Electronic address:

Background: Objective of the present study was to conduct an 8-week double-blind, randomized, placebo-controlled trial to test the efficacy of pioglitazone in the treatment of bipolar depression.

Methods: 38 outpatients with bipolar disorder and current major depressive episode were randomized to pioglitazone (15-45 mg/day) or placebo. The use of concomitant mood stabilizers, antipsychotics, and antidepressants was permitted. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.090DOI Listing
February 2019
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Psychological distress in cancer patients in a large Chinese cross-sectional study.

J Affect Disord 2019 02 13;245:950-956. Epub 2018 Nov 13.

Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1941 East Road, Houston 77054, TX, USA. Electronic address:

Background: Although psychological distress is common among patients with chronic diseases, the degree of risk for developing psychological distress is not well-established. Our aim with this study is to determine the odds ratio for psychological distress in patients with cancer as compared to either 1) patients with chronic disease patients without cancer, or 2) healthy controls in a large representative sample of Chinese population.

Methods: Using a multistage, stratified cluster sampling method, 21,101 subjects 18-79 years old were interviewed face-to-face in Jilin province, China. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183165
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http://dx.doi.org/10.1016/j.jad.2018.11.089DOI Listing
February 2019
2 Reads
3.383 Impact Factor

Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice.

J Affect Disord 2019 02 13;245:939-949. Epub 2018 Nov 13.

Department of Pharmacy, Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, the First Affiliated Hospital of Wenzhou Medical University, 325000, China. Electronic address:

Background: Statins play a beneficial role in the treatment of coronary artery disease and are widely prescribed to prevent hypercholesterolemia. Previous studies have demonstrated that statins also have anti-inflammatory and immunomodulatory properties, and these are being explored for potential benefits in depression. However, the role of statins in the treatment of depression has not been well examined. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.086DOI Listing
February 2019

The association between child and adolescent depression and poor attendance at school: A systematic review and meta-analysis.

J Affect Disord 2019 02 7;245:928-938. Epub 2018 Nov 7.

University of Exeter Graduate School of Education, Exeter, United Kingdom.

Background: Depression in young people may lead to reduced school attendance through social withdrawal, loss of motivation, sleep disturbance and low energy. We systematically reviewed the evidence for an association between depression and poor school attendance.

Methods: Seven electronic databases were searched for quantitative studies with school-aged children and/or adolescents, reporting a measure of association between depression and school attendance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183129
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http://dx.doi.org/10.1016/j.jad.2018.11.055DOI Listing
February 2019
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Association of secondhand smoke and depressive symptoms in nonsmoking pregnant Women: A systematic review and meta-analysis.

J Affect Disord 2019 02 9;245:918-927. Epub 2018 Nov 9.

St. Luke's International University, Graduate School of Nursing Science, Global Health Nursing, 10-1 Akashi-cho, Chuo-ku, Tokyo 1040044, Japan. Electronic address:

Background: Globally about 30% of adult women and 40% of children are exposed to secondhand smoke (SHS) from active smokers. SHS exposure of pregnant women has been associated with postpartum depression. Unexposed women in pregnancy had lower rates of postpartum depression than women exposed to SHS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183023
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http://dx.doi.org/10.1016/j.jad.2018.11.048DOI Listing
February 2019
8 Reads
3.383 Impact Factor

Decline in sexuality and wellbeing in older adults: A population-based study.

J Affect Disord 2019 02 13;245:912-917. Epub 2018 Nov 13.

The Cambridge Centre for Sports & Exercise Sciences, Anglia Ruskin University, Cambridge, UK.

Background: Age-related declines in sexuality and increase in mental health complications have been well documented. However, whether these two phenomena are related has not been explored. The present study therefore aimed to investigate associations between a decline in sexuality and markers of mental health and wellbeing. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.091DOI Listing
February 2019

Prospective associations of androgens and sex hormone-binding globulin with 12-month, lifetime and incident anxiety and depressive disorders in men and women from the general population.

J Affect Disord 2019 02 9;245:905-911. Epub 2018 Nov 9.

Department of Physiological and Clinical Psychology, University of Greifswald, Greifswald, Germany.

Background: Findings on associations of androgens and sex hormone-binding globulin (SHBG) with anxiety and depressive disorders in the general population remain inconclusive.

Methods: We used data of n = 993 men and n = 980 women from the Study of Health in Pomerania (SHIP, a prospective-longitudinal general population study from northeastern Germany). Immunoassay-measured serum concentrations of total testosterone, androstenedione and SHBG were assessed when participants were aged 20-80. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.052DOI Listing
February 2019
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Depression symptomatology correlates with event-related potentials in Parkinson's disease: An affective priming study.

J Affect Disord 2019 02 13;245:897-904. Epub 2018 Nov 13.

UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane & Women's Hospital, Herston, Brisbane QLD4029, Australia; School of Health & Rehabilitation Sciences, The University of Queensland, St Lucia, Brisbane QLD4067, Australia.

Background: Depression is a predominant non-motor symptom of Parkinson's disease (PD), which is often under recognised and undertreated. To improve identification of depression in PD it is imperative to examine objective brain-related markers. The present study addresses this gap by using electroencephalography (EEG) to evaluate the processing of emotionally valanced words in PD. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.094DOI Listing
February 2019

Concordance of genetic variation that increases risk for anxiety disorders and posttraumatic stress disorders and that influences their underlying neurocircuitry.

J Affect Disord 2019 02 13;245:885-896. Epub 2018 Nov 13.

Department of Psychiatry and MRC Unit on Risk & Resilience. University of Cape Town. Cape Town. South Africa; Groote Schuur Hospital. Cape Town. South Africa. Electronic address:

Background: There have been considerable recent advances in understanding the genetic architecture of anxiety disorders and posttraumatic stress disorder (PTSD), as well as the underlying neurocircuitry of these disorders. However, there is little work on the concordance of genetic variations that increase risk for these conditions, and that influence subcortical brain structures. We undertook a genome-wide investigation of the overlap between the genetic influences from single nucleotide polymorphisms (SNPs) on volumes of subcortical brain structures and genetic risk for anxiety disorders and PTSD. Read More

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http://dx.doi.org/10.1016/j.jad.2018.11.082DOI Listing
February 2019
2 Reads
3.383 Impact Factor