911,943 results match your criteria Journal of Women & Aging [Journal]


Impact of Deployment on Reproductive Health in U.S. Active-Duty Servicewomen and Veterans.

Semin Reprod Med 2018 Nov 19;36(6):361-370. Epub 2019 Apr 19.

Informatics, Decision Enhancement, and Analytic Sciences (IDEAS) Center, VA Salt Lake City Health Care System, Salt Lake City, Utah.

Reproductive-age women are a fast-growing component of active-duty military personnel who experience deployment and combat more frequently than previous service-era women Veterans. With the expansion of the number of women and their roles, the United States Departments of Defense and Veterans Affairs have prioritized development and integration of reproductive services into their health systems. Thus, understanding associations between deployments or combat exposures and short- or long-term adverse reproductive health outcomes is imperative for policy and programmatic development. Read More

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http://dx.doi.org/10.1055/s-0039-1678749DOI Listing
November 2018

The Department of Defense Birth and Infant Health Research Program: Assessing the Reproductive Health of U.S. Active-Duty Women.

Semin Reprod Med 2018 Nov 19;36(6):351-360. Epub 2019 Apr 19.

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland.

As the percentage of women serving in the active-duty military continues to grow, and as their roles continue to expand, the importance of monitoring reproductive health in the military community increases. The Department of Defense Birth and Infant Health Research (BIHR) program conducts ongoing epidemiologic studies to assess potential increased risks for adverse reproductive and infant health outcomes in the military population. Military personnel endure unique physical and mental demands as a part of their occupational duties (e. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678751
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http://dx.doi.org/10.1055/s-0039-1678751DOI Listing
November 2018
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The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen.

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678752
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http://dx.doi.org/10.1055/s-0039-1678752DOI Listing
November 2018
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Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
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Neurological and neuropsychological outcome after resection of craniopharyngiomas.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

OBJECTIVECraniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality of life have been neglected for many decades. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.10.JNS181557DOI Listing
April 2019
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The effect of atorvastatin on cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia: A pilot study.

Pharmacol Rep 2019 Jan 31;71(3):417-421. Epub 2019 Jan 31.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Individuals with non-classic congenital adrenal hyperplasia (NC-CAH) often show evidence of hyperandrogenism, including premature pubarche, accelerated linear growth velocity, short final height, hirsutism, acne, alopecia, impaired ovulation, menstrual dysfunction and subfertility. Although statins were found to reduce elevated levels of androgens in subjects with this disorder, no previous study has investigated whether 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors affect cardiometabolic risk factors in patients with NC-CAH.

Methods: We studied 12 women with NC-CAH, 6 of whom because of coexisting hypercholesterolemia received atorvastatin (20-40 mg daily). Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.014DOI Listing
January 2019

Comparison of body composition and overactive bladder symptoms in overweight female university students.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 2;237:18-22. Epub 2019 Apr 2.

Department of Public Health, Jessenius Faculty of Medicine, Martin, Comenius University Bratislava, Slovak Republic.

Objectives: To compare body composition in young overweight women with OAB compared to women without OAB, and to determine the severity of the symptoms of OAB, as well as to investigate the impact of OAB on quality of life.

Study Design: Cross-sectional study. The sample consisted of 1932 enrolled women classed as overweight (BMI:25-29. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.001DOI Listing

Early stage detection and screening of ovarian cancer: A research opportunity and significant challenge for biosensor technology.

Biosens Bioelectron 2019 Mar 20;135:71-81. Epub 2019 Mar 20.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6. Electronic address:

Women diagnosed with late-stage ovarian cancer suffer a very high rate of mortality. Accordingly, it is imperative to detect and diagnose the disease as early as possible in its development. Achievement of this aim implies relatively large scale screening of women at an age of clinically significance through assay of biomarkers for disease present in blood or serum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193024
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http://dx.doi.org/10.1016/j.bios.2019.03.041DOI Listing
March 2019
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Indigenous Doulas: A literature review exploring their role and practice in western maternity care.

Midwifery 2019 Apr 16;75:52-58. Epub 2019 Apr 16.

Charles Darwin University, Australia.

Objective: The purpose of this article is to establish a body of literature exploring the emergent topic of Indigenous doulas, in relation to Indigenous communities in remote locations, where women are routinely evacuated and no longer supported to give birth. In doing so the article will synthesise and critique key concepts in the literature and identify gaps for prioritisation in future research.

Design: The methodology is influenced by Indigenous, decolonising and feminist theoretical standpoints. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02666138193008
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http://dx.doi.org/10.1016/j.midw.2019.04.005DOI Listing
April 2019
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[Prophylactic hysterectomy in Lynch syndrome: feasibility and outcomes].

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université Paris Descartes, INSERM UMR-S 747, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Electronic address:

Objectives: Lynch syndrome (LS) is a hereditary predisposition to cancers, first of all, colo-rectal and endometrial cancers in women. Although recommended, gynecologic screening has never proven its benefit. Prophylactic surgery can be consider once the parental project is completed. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.04.010DOI Listing

A machine learning approach to knee osteoarthritis phenotyping: Data from the FNIH Biomarkers Consortium.

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Objective: Knee osteoarthritis (KOA) is a heterogeneous condition representing a variety of potentially distinct phenotypes. The purpose of this study was to apply innovative machine learning approaches to KOA phenotyping in order to define progression phenotypes that are potentially more responsive to interventions.

Design: We used publicly available data from the FNIH OA Biomarkers Consortium, where radiographic (medial joint space narrowing of ≥0. Read More

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http://dx.doi.org/10.1016/j.joca.2018.12.027DOI Listing

Ca-PKCα-ERK1/2 signaling pathway is involved in the suppressive effect of propofol on proliferation of neural stem cells from the neonatal rat hippocampus.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, PR China. Electronic address:

Neonatal exposure to propofol induces persistent behavioral abnormalities in adulthood. In addition to triggering the apoptosis of neurons in the developing brain, anesthetics may contribute to the development of cognitive deficits by interfering neurogenesis. Given the importance of neural stem cell (NSC) proliferation in neurogenesis, the effect of propofol on NSC proliferation and the mechanisms underlying this effect were investigated. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.005DOI Listing

What is needed now for successful scale-up of screening?

Papillomavirus Res 2019 Apr 16. Epub 2019 Apr 16.

PATH, Seattle, USA.

Effective screening for pre-cancerous lesions of the cervix is the only protective intervention that can be offered to women that have not had the opportunity to be vaccinated. Elimination goals are being developed so that by 2030, 70% of women aged 35-45 years should have been screened at least once in a lifetime and 90% of all detected lesions should have been treated. These goals focus on a substantial reduction of cervical cancer burden in low- and middle-income countries (LMICs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058521193003
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http://dx.doi.org/10.1016/j.pvr.2019.04.011DOI Listing
April 2019
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The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.

Alcohol 2019 Apr 16. Epub 2019 Apr 16.

Division of Endocrine and Metabolic Disease, Center for Biomedical Sciences, Korea National Institute of Health, Cheongju, Chungbuk, 28159, South Korea.

Background: Excessive alcohol consumption is a major public health problem in East Asian countries. Alcohol use leads to a cascade of problems including increased chances of risky behavior and wide range of negative health consequences from alcoholic liver disease to upper gastric and liver cancer. These alcohol effects are known to be influenced by ethnic variability and genetics. Read More

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http://dx.doi.org/10.1016/j.alcohol.2019.03.004DOI Listing

Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian cancer.

J Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Department of Human Genetics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Ovarian tumor is one of the leading causes of cancer among women. Patients are diagnosed at an advanced stage, usually. There is a need for new specific and sensitive biomarkers. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.04.015DOI Listing

Predictive accuracy of the breast cancer genetic risk model based on eight common genetic variants: The BACkSIDE study.

J Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava (JFMED UK), Slovakia.

Breast cancer (BC) development is caused by the interaction of environmental and genetic factors. At least 90 susceptible genetic variants with different population penetration and incidence have been associated with BC. This paper therefore analysed the individual discrimination power of 8 low penetrant common genetic variants and calculated the predictive accuracy of the genetic risk model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.014DOI Listing
April 2019
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Positive association between facial and vocal femininity/masculinity in women but not in men.

Behav Processes 2019 Apr 16. Epub 2019 Apr 16.

Department of Experimental Psychology, Institute of Psychology, University of Sao Paulo, Sao Paulo, Brazil.

Multicomponent stimuli improve information reception. In women, perceived facial and vocal femininity-masculinity (FM) are concordant; however, mixed results are found for men. Some feminine and masculine traits are related to sex hormone action and can indicate reproductive qualities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03766357183015
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http://dx.doi.org/10.1016/j.beproc.2019.04.010DOI Listing
April 2019
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Increased HPV detection by the use of a pre-heating step on vaginal self-samples analysed by Aptima HPV assay.

J Virol Methods 2019 Apr 16. Epub 2019 Apr 16.

Department of Medical Microbiology, Laboratory Medicine Region Skåne, Lund University, Lund, Sweden. Electronic address:

Background: We recently reported a sensitivity of 85.5% to detect high-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS)/cancer by the use of self-collected vaginal samples analysed by the Aptima mRNA HPV assay (AHPV).

Objectives: To increase detection of HPV among self-samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934193011
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http://dx.doi.org/10.1016/j.jviromet.2019.04.015DOI Listing
April 2019
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Circulating PCSK9 concentrations are increased in postmenopausal women with the metabolic syndrome.

Clin Chim Acta 2019 Apr 16. Epub 2019 Apr 16.

School of Allied Health Sciences, Walailak University, 222 Thaiburi, Thasala, Nakhon Si Thammarat, Thailand. Electronic address:

Background: High PCSK9 concentrations are associated with an increased risk of cardiovascular disease (CVD). We investigated PCSK9 concentrations and their association with metabolic parameters in Thai subjects and to compare PCSK9 concentrations in pre- and postmenopausal women with and without metabolic syndrome (MetS).

Methods: Anthropometric data, serum lipids, fasting blood glucose (FBG), and PCSK9 concentrations were measured in 436 Thai subjects (152 men, 143 premenopausal, and 141 postmenopausal women). Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.067DOI Listing

Abortion Providers' experiences and views on self-managed medication abortion, an exploratory study.

Contraception 2019 Apr 16. Epub 2019 Apr 16.

University of Iowa Hospitals and Clinics, Department of Obstetrics and Gynecology, 200 Hawkins Drive, Iowa City, IA, 52242.

Objective: Data on the practice of self-managed medication abortion are limited, in part because this practice takes place purposefully outside of established healthcare systems. Given this, we aimed to ascertain abortion providers' familiarity with self-managed medication abortion and associated complications, compare regional differences, and evaluate provider attitudes.

Study Design: We distributed an online survey to members of Society for Family Planning, Association of Reproductive Health Providers, and the Abortion Care Network between July and September 2017 querying experiences with and opinions about self-managed abortion. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.04.006DOI Listing
April 2019
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Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.

J Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America. Electronic address:

Urinary tract infections (UTIs) are the most commonly reported infections in adult women and have high rates of recurrence, especially in postmenopausal women. Recurrent UTI (RUTI) greatly reduces quality of life, places a significant burden on the healthcare system, and contributes to antimicrobial resistance. Because treatment of RUTI by long-term antibiotic therapy is often ineffective or poorly tolerated in elderly women, new therapies must be developed. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.008DOI Listing

SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Intermittent hypoxia impairs uterine artery function in pregnant mice.

J Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Key Points: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Read More

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http://dx.doi.org/10.1113/JP277775DOI Listing

Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women.

PLoS One 2019 19;14(4):e0215550. Epub 2019 Apr 19.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon- Accra, Ghana.

Background: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana.

Methods: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215550PLOS

Chlamydia trachomatis bacterial load, estimated by Cq values, in urogenital samples from men and women visiting the general practice, hospital or STI clinic.

PLoS One 2019 19;14(4):e0215606. Epub 2019 Apr 19.

Department of Medical Microbiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center (MUMC+), AZ Maastricht, the Netherlands.

Background: The bacterial load of Chlamydia trachomatis (CT) is assumed to play a role in transmission and sequelae. We assessed urogenital CT cycle quantification (Cq) values, as an indicator for CT load, of men and women diagnosed by general practitioners (GPs), hospital physicians and the STI clinic.

Methods: Urogenital CT-positive samples (n = 2,055 vaginal swabs, n = 77 cervical swabs, n = 1,519 urine samples and n = 19 urethral swabs) diagnosed by GPs, hospital physicians and the STI clinic from the Maastricht Medical Microbiology Laboratory were included (2012-2016). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215606PLOS

Risk factors for gestational diabetes: An umbrella review of meta-analyses of observational studies.

PLoS One 2019 19;14(4):e0215372. Epub 2019 Apr 19.

Cyprus International Institute for Environmental & Public Health, Cyprus University of Technology, Limassol, Cyprus.

Background/objective: Gestational diabetes mellitus (GDM) is a common pregnancy complication, with complex disease mechanisms, and several risk factors may contribute to its onset. We performed an umbrella review to summarize the evidence from meta-analyses of observational studies on risk factors associated with GDM, evaluate whether there are indications of biases in this literature and identify which of the previously reported associations are supported by convincing evidence.

Methods: We searched PubMed and ISI Web of Science from inception to December 2018 to identify meta-analyses examining associations between putative risk factors for GDM. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215372PLOS

Effect of HIV-exposure and timing of anti-retroviral treatment on immunogenicity of trivalent live-attenuated polio vaccine in infants.

PLoS One 2019 19;14(4):e0215079. Epub 2019 Apr 19.

South African Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.

Introduction: The prevalence of HIV infection in South African pregnant women has been approximately 30% over the past decade; however, there has been a steady decline in mother-to-child transmission of HIV from 8% in 2008 to <2% in 2015. We evaluated the immunogenicity of live-attenuated trivalent oral polio vaccine (OPV) following the primary vaccination series (doses at birth, 6, 10 and 14 weeks of age) in HIV-exposed uninfected (HEU), HIV-infected infants initiated on early anti-retroviral treatment (HIV+/ART+), HIV-infected infants on deferred ART (HIV+/ART-) and HIV-unexposed infants (HU) as the referent group.

Methods: Serum polio neutralization antibody titres were evaluated to serotype-1, serotype-2 and serotype-3 at 6, 10 and 18 weeks of age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215079PLOS

Correlates of continuum of maternal health services among Nepalese women: Evidence from Nepal Multiple Indicator Cluster Survey.

PLoS One 2019 19;14(4):e0215613. Epub 2019 Apr 19.

Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Continuum of Care (CoC) is an essential strategy to prevent maternal and child deaths where health services are arranged in a pathway throughout pregnancy, childbirth and after delivery. However, CoC is still a challenge in Nepal. This study aimed to investigate the correlates of CoC from pregnancy to the postnatal period in Nepalese women aged 15 to 49 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215613PLOS

Association Between Changes in Postpartum Weight and Waist Circumference and Changes in Cardiometabolic Risk Factors Among Women With Recent Gestational Diabetes.

Prev Chronic Dis 2019 Apr 18;16:E47. Epub 2019 Apr 18.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.

Introduction: Women with gestational diabetes mellitus (GDM) have a 30% to 70% risk for developing type 2 diabetes and are at increased risk for cardiovascular disease. Little is known about how anthropometric changes in the first postpartum year modify cardiometabolic risk factors.

Methods: We randomly assigned women in the Balance After Baby study to an intervention group consisting of participation in a web-based lifestyle program or to a control group in which no program was offered. Read More

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http://dx.doi.org/10.5888/pcd16.180308DOI Listing

Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):47-50

Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Type 2 diabetes mellitus (T2DM) is the most common metabolic and multifactorial disease in which both genetic and environmental factors are involved. In diabetes, the defects in the cellular metabolism result in higher levels of free radicals. These radicals react with other vital cellular molecules, which are responsible in diabetes side effects and known as diabetic retinopathy (DR), a disease of the retina that results in impairment or loss of vision. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2019025074DOI Listing
January 2019

Evaluation of Three Rapid Screening Tests for Detection of Hepatitis C Antibodies on Mass Scale.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):25-28

Department of Biotechnology, International Islamic University, Islamabad, Pakistan.

Hepatitis C virus (HCV) is a leading health problem across the globe. Only 20% of HCV positive individuals know their positive disease status. Effective HCV screening tests are required to screen both general and high-risk populations and identify the silent cases of HCV. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025062DOI Listing
January 2019
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Preventive Misconception and Risk Behaviors in a Multinational HIV Prevention Trial.

AJOB Empir Bioeth 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Population Health Sciences , Duke University School of Medicine , Durham , North Carolina , USA.

Background: Some HIV prevention research participants may hold a "preventive misconception" (PM), an overestimate of the probability or level of personal protection afforded by trial participation. However, these reports typically rely upon small, retrospective qualitative assessments that did not use a standardized approach.

Methods: We administered a measure of PM called PREMIS, during Microbicide Trials Network 020-A Study to Prevent Infection with a Ring for Extended Use, a large, multicenter, placebo-controlled, phase III trial evaluating the safety and efficacy of a dapivirine vaginal ring among women at risk for HIV infection in Malawi, South Africa, Uganda, and Zimbabwe. Read More

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https://www.tandfonline.com/doi/full/10.1080/23294515.2019.1
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http://dx.doi.org/10.1080/23294515.2019.1593257DOI Listing
April 2019
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Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.

J Clin Oncol 2019 Apr 19:JCO1801568. Epub 2019 Apr 19.

1 University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Purpose: To evaluate the impact of two different intraperitoneal (IP) chemotherapy regimens on progression-free survival (PFS) among women with newly diagnosed advanced ovarian carcinoma.

Methods: Eligible patients were randomly assigned to six cycles of IV paclitaxel 80 mg/m once per week with intravenous (IV) carboplatin area under the curve 6 (IV carboplatin) versus IV paclitaxel 80 mg/m once per week with IP carboplatin area under the curve 6 (IP carboplatin) versus once every 3 weeks IV paclitaxel 135 mg/m over 3 hours day 1, IP cisplatin 75 mg/m day 2, and IP paclitaxel 60 mg/m day 8 (IP cisplatin). All participants received bevacizumab 15 mg/kg IV every 3 weeks in cycles 2 to 22. Read More

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http://dx.doi.org/10.1200/JCO.18.01568DOI Listing

Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model.

FASEB J 2019 Apr 19:fj201802347RRR. Epub 2019 Apr 19.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Aromatase inhibitors are the preferred treatment for certain women with estrogen receptor (ER)-positive breast cancer, but evidence suggests that women with obesity experience aromatase inhibitor resistance at higher rates. To compare how stromal cells derived from women who are lean or obese influence response to the aromatase inhibitor (anastrazole), we incorporated patient-derived stroma in a previously characterized MCF7-derived duct model. Coculture with adipose stromal cells enabled the metabolism of testosterone (T) to E, which induced estrogen response element activity, epithelial proliferation, and hyperplasia in MCF7 cells. Read More

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http://dx.doi.org/10.1096/fj.201802347RRRDOI Listing

HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals.

J Clin Lab Anal 2019 Apr 19:e22900. Epub 2019 Apr 19.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: This study was conducted to investigate the association of carcinoembryonic antigen (CEA) and glycated hemoglobin (HbA1c) in normal, prediabetic, and diabetic subjects.

Methods: A total of 2,911 participants who underwent general health checkups were enrolled and categorized into the normal, prediabetes, and diabetes groups. Demographic, anthropological, and clinical variables were investigated, and correlations with CEA were analyzed. Read More

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http://dx.doi.org/10.1002/jcla.22900DOI Listing

Prevalence of polycystic ovary syndrome in a metabolically healthy obese population.

Int J Gynaecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Objective: To determine whether polycystic ovary syndrome (PCOS) prevalence is increased among metabolically healthy obese (MHO) women.

Methods: A national epidemiologic survey in 10 provinces and municipalities of China between October 2007 and September 2011. Women were stratified into four groups according to metabolic health (Assessment by Adult Treatment Panel III) and obesity (body mass index [BMI] ≥28): metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), MHO, and metabolically unhealthy obese (MUO). Read More

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http://dx.doi.org/10.1002/ijgo.12824DOI Listing

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study.

JAMA Netw Open 2019 Apr 5;2(4):e192745. Epub 2019 Apr 5.

Framingham Heart Study, Framingham, Massachusetts.

Importance: Dementia risk may be attenuated by physical activity (PA); however, the specific activity levels optimal for dementia prevention are unclear. Moreover, most older adults are unable to meet the nationally recommended PA guidelines, set at 150 minutes of moderate to vigorous PA per week.

Objective: To assess the association of total steps walked per day and total dose (intensity × duration) of PA with brain volumes on magnetic resonance imaging (MRI) among Framingham Heart Study participants. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2745DOI Listing

Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants.

JAMA Netw Open 2019 Apr 5;2(4):e192696. Epub 2019 Apr 5.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations.

Objectives: To evaluate the association of diabetes with all-cause and cause-specific mortality in Asia and to investigate potential effect modifications of the diabetes-mortality associations by participants' age, sex, education level, body mass index, and smoking status. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2696DOI Listing
April 2019
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Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)-Positive Breast Cancer.

JAMA Netw Open 2019 Apr 5;2(4):e192561. Epub 2019 Apr 5.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

Importance: There has been significant recent interest in understanding the utility of quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic response. No clinically accepted biomarkers are as yet available for estimation of response to human epidermal growth factor receptor 2 (currently known as ERBB2, but referred to as HER2 in this study)-targeted therapy in breast cancer.

Objective: To determine whether imaging signatures on clinical breast magnetic resonance imaging (MRI) could noninvasively characterize HER2-positive tumor biological factors and estimate response to HER2-targeted neoadjuvant therapy. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2561DOI Listing

Association of Maternal Cigarette Smoking and Smoking Cessation With Preterm Birth.

JAMA Netw Open 2019 Apr 5;2(4):e192514. Epub 2019 Apr 5.

Department of Community Health Sciences, University of California, Los Angeles.

Importance: Cigarette smoking during pregnancy increases the risk of preterm birth, low birth weight, and infant mortality.

Objective: To assess the probability of preterm birth among expectant mothers who smoked cigarettes before pregnancy and quit smoking at the start or during pregnancy.

Design, Setting, And Participants: This cross-sectional study analyzed information provided on live birth certificates from 2011 through 2017 that were obtained from US states that implemented the 2003 revision of the US live birth certificate. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2514DOI Listing

Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.

JAMA Netw Open 2019 Apr 5;2(4):e192416. Epub 2019 Apr 5.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Head-to-head randomized clinical trials showed greater efficacy of denosumab vs alendronate in improving bone mineral density. Although there is an association of changes in bone mineral density with reductions in fracture risk, the magnitude of the association is not well established.

Objective: To compare the risk of hip and any fracture in patients treated with denosumab and alendronate in routine practice settings. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2416DOI Listing
April 2019
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Is the Sum Greater than its Parts? Variations in Substance-Related Consequences by Conjoint Alcohol-Marijuana Use Patterns.

J Psychoactive Drugs 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Psychology , Palo Alto University , Palo Alto , CA , USA.

Alcohol and marijuana are the most commonly used substances for college-attending young adults. This study evaluated differences in substance-specific consequence attribution by alcohol-marijuana use patterns (concurrent alcohol and marijuana [CAM; use of both substances, not at same time] and simultaneous [SAM; use of both, at same time]) as well as alcohol-only (AO). First-year college students with prior alcohol use (N = 610, 50. Read More

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http://dx.doi.org/10.1080/02791072.2019.1599473DOI Listing

Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

Unid Reabilit Cardiovasc e Fisiol do Exerc, Heart Institute (InCor), University of Sao Paulo Medical School and School of Physical Education and Sport, University of Sao Paulo, Brazil.

Aims: To test if doxorubicin (DX) and cyclophosphamide (CY) adjuvant chemotherapy (CHT) acutely impairs neurovascular and hemodynamic responses in women with breast cancer.

Methods: Sixteen women (age:47.0±2. Read More

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http://dx.doi.org/10.1152/ajpheart.00756.2018DOI Listing

The association between clinical and laboratory parameters in thyroid disease and nonthyroidal illness in young women.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2950-2959

Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.

Objective: Evidence from epidemiological and clinical studies strongly suggest that young women in the preconception period are a group at risk for thyroid disorders which may lead to further aggravation of pre-existing chronic thyroid disease and complications during pregnancy.

Materials And Methods: This paper is a literature review focusing on articles published in English between 2014-2017 searched in Medline database using terms 'young women', 'subclinical hyperthyroidism', 'subclinical hypothyroidism', 'nonthyroidal illness syndrome', 'obesity', 'depression'.

Conclusions: Clinical assessment of young female patient including that of obtaining full medical history with a focus on the perceived changes in appearance, psychological symptoms and menstrual irregularities supported by laboratory tests indicative of metabolic status and characteristic changes in thyroid functions, may be the key to well-reasoned and justified individual therapeutic decisions. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17575DOI Listing

[Association of Strategy of Direct Stenting of Infarct-Related Artery with Reduction of Mortality in Woman with ST-Elevation Myocardial Infarction].

Kardiologiia 2019 Apr 16;59(4):5-11. Epub 2019 Apr 16.

Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences.

Aim of this study was to evaluate the impact of direct stenting (DS) strategy on the results of treatment of female patients with STelevation myocardial infarction (STEMI) undergoing percutaneous coronary interventions (PCIs).

Materials And Methods: Among 1297 patients with STEMI admitted to the coronary care unit and subjected to PCIs from 2006 to 2015 there were 330 women (25.4 %). Read More

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http://dx.doi.org/10.18087/cardio.2019.4.10246DOI Listing

Total laparoscopic hysterectomy for enlarged uteri: factors associated with the rate of conversion to open surgery.

J Obstet Gynaecol 2019 Apr 19:1-6. Epub 2019 Apr 19.

a Dipartimento Scienze della Salute della Donna e del Bambino , Fondazione Policlinico Univeristario A. Gemelli, IRCCS , Rome , Italy ;

A hysterectomy for enlarged uteri is considered a challenge for gynaecologic surgeons, due to the limit of exposure to surgical spaces. Our objective is to investigate the different variables that may have an impact on the risk of conversion to open surgery. This is a retrospective cohort study consisting of 133 women who were submitted to surgery for uterine fibroids and who underwent total hysterectomy by laparoscopic approach attempt. Read More

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http://dx.doi.org/10.1080/01443615.2019.1575342DOI Listing

Antepartum and postpartum uterine artery impedance in women with pre-eclampsia: a case control study.

J Obstet Gynaecol 2019 Apr 19:1-6. Epub 2019 Apr 19.

a Department of Obstetrics and Gynecology , KasrAlAini Hospital Cairo University , Cairo , Egypt.

This is a cohort study which included 100 cases with pre-eclampsia (PE) and 100 controls, done to compare the antepartum and postpartum uterine artery (UtA) Doppler velocimetry between them. UtA PI and RI were measured before and within 48-72 h after delivery. There was a highly significant difference between the cases and controls, regarding the UtA RI (0. Read More

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http://dx.doi.org/10.1080/01443615.2018.1563054DOI Listing

Efficacy and tolerability of 1% ciclopirox shampoo in the treatment of moderate-to-severe scalp seborrheic dermatitis: a multicenter, prospective, assessor-blinded trial.

G Ital Dermatol Venereol 2019 Jun;154(3):342-346

Difa Cooper, Caronno Pertusella, Varese, Italy -

Background: Seborrheic dermatitis (SD) is a very common inflammatory skin disease. It occurs in 1-3% of the population. The most supported pathogenetic theory links SD to dandruff via a common etiology, yeasts of the genus Malassezia. Read More

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http://dx.doi.org/10.23736/S0392-0488.17.05623-1DOI Listing

Moderate-to-severe psoriasis and pregnancy: impact on fertility, pregnancy outcome and treatment perspectives.

G Ital Dermatol Venereol 2019 Jun;154(3):305-314

Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Psoriasis affects 2-4% of the world's population, with no difference between men and women and 70% of patients experiencing disease onset before the age of 40, which coincides with the reproductive years. Few data are available from literature on impact of psoriasis on fertility, course and outcome of pregnancy and risk associated with treatments. Recent studies on other immune-mediated inflammatory diseases, among which psoriasis is also included, indicate that rheumatoid arthritis and inflammatory bowel diseases can impact female fertility and pregnancy outcomes especially during active disease episodes. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.06255-7DOI Listing
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