46,414 results match your criteria Journal of Virology[Journal]


HIV-1 subtype C with PYxE insertion has enhanced binding of Gag-p6 to host cell protein ALIX and increased replication fitness.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

Human immunodeficiency virus type 1 subtype C (HIV-1C) has a natural deletion of a YPxL motif in its Gag-p6 late domain. This domain mediates the binding of Gag to host cell protein ALIX and subsequently facilitates viral budding. In a subset of HIV-1C infected individuals, the tetrapeptide insertion PYxE has been identified at the deleted YPxL motif site. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00077-19DOI Listing
February 2019
1 Read

Effect of Previous Respiratory Syncytial Virus Infection on Murine Immune Responses to F and G Protein Containing Virus-like Particles.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology and Physiological Systems, Program in Immunology and Microbiology, University of Massachusetts Medical School, Worcester, MA.

Most individuals are infected with respiratory syncytial virus (RSV) by age two, but infection does not result in long-term protective immunity to subsequent infections. Previous RSV infection may, however, impact responses to an RSV vaccine. The goal of these studies was to explore the effect of previous RSV infection on murine antibody responses to RSV F and G protein containing virus-like particles (VLP), comparing responses to those resulting from VLP immunization of RSV naïve animals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00087-19DOI Listing
February 2019

The IκB kinases restrict human cytomegalovirus infection.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America

Human Cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes disease in immunosuppressed populations. HCMV has a complex relationship with innate immune signaling pathways. Specifically, HCMV has been found to block some aspects of inflammatory signaling while benefiting from others. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.02030-18
Publisher Site
http://dx.doi.org/10.1128/JVI.02030-18DOI Listing
February 2019
2 Reads

Genome characterization, prevalence and transmission mode of a novel picornavirus associated with the Threespine Stickleback fish ().

J Virol 2019 Feb 13. Epub 2019 Feb 13.

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook NY, USA

The complete genome sequence of an RNA virus was assembled from RNA sequencing of virus particles purified from threespine stickleback intestine tissue samples. This new virus is most closely related to the Eel Picornavirus and can be assigned to the genus in the family Its unique genetic properties are enough to establish a new species, dubbed the Threespine Stickleback Picornavirus (TSPV). Due to their broad geographic distribution throughout the northern hemisphere and parallel adaptation to freshwater, threespine sticklebacks have become a model in evolutionary ecology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02277-18DOI Listing
February 2019
1 Read

Turnip mosaic virus is a second example of a virus using transmission activation for plant-to-plant propagation by aphids.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

BGPI, INRA Centre Occitanie, SupAgro, CIRAD, Université de Montpellier, Montpellier, France

Cauliflower mosaic virus (CaMV, family ) responds to the presence of aphid vectors on infected plants by forming specific transmission morphs. This phenomenon, coined transmission activation (TA), controls plant-to-plant propagation of CaMV. A fundamental question is whether other viruses rely on TA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01822-18DOI Listing
February 2019
4.439 Impact Factor

Manipulation of aphid behavior by a persistent plant virus.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Plant Pathology and Environmental Microbiology, Pennsylvania State University, University Park, PA 16802, USA

Plants are frequently infected with cytoplasmic RNA viruses that persist for many generations through nearly 100% vertical transmission without producing any symptoms. Movement between plant cells and horizontal transmission has not been observed in these viruses; instead they are distributed to all host cells through host cell division. Jalapeño peppers () are all infected with 1 (PCV 1, family ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01781-18DOI Listing
February 2019

The US11 gene of Herpes Simplex Virus 1 promotes neuroinvasion and periocular replication following corneal infection.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH.

Herpes simplex virus type 1 (HSV-1) cycles between phases of latency in sensory neurons and replication in mucosal sites. HSV-1 encodes two key proteins that antagonize the shutdown of host translation; US11 through preventing PKR activation, and ICP34.5 through mediating eIF2α dephosphorylation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02246-18DOI Listing
February 2019
1 Read

Prime boost immunisations with DNA, MVA and protein-based vaccines elicit robust HIV-1, Tier 2 neutralizing antibodies against the CAP256 superinfecting virus.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa.

A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. Here we assessed the immunogenicity of the CAP256SU envelope protein delivered by modified vaccinia virus Ankara (M) and DNA (D) vaccines in different prime/boost combinations followed by a soluble protein (P) boost. The envelope protein (Env) contained a flexible, glycine linker and I559P mutation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02155-18DOI Listing
February 2019
1 Read

Molecular basis of a protective/neutralizing monoclonal antibody targeting envelope proteins of both tick-borne encephalitis virus and louping ill virus.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China

Tick-borne encephalitis virus (TBEV) and louping ill virus (LIV) are members of the tick-borne flaviviruses (TBFVs) in the family , which cause encephalomeningitis and encephalitis in humans and other animals. Although vaccines against TBEV and LIV are available, infection rates are rising due to the low vaccination coverage. To date, no specific therapeutics have been licensed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02132-18DOI Listing
February 2019

Comparison of HSV-1 strains circulating in Finland demonstrates the uncoupling of whole-genome relatedness and phenotypic outcomes of viral infection.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA

A majority of adults in Finland are seropositive carriers of herpes simplex viruses (HSV). Infection occurs at epithelial or mucosal surfaces, after which virions enter innervating nerve endings, eventually establishing lifelong infection in neurons of the sensory or autonomic nervous system. Recent data have highlighted the genetic diversity of HSV-1 strains, and demonstrated apparent geographic patterns in strain similarity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01824-18DOI Listing
February 2019

Cytoplasm and Beyond: The Dynamic Innate Immune Sensing of Influenza A Virus by RIG-I.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, Canada S7N 5E3

Innate immune sensing of influenza A virus (IAV) requires RIG-I, a fundamental cytoplasmic RNA sensor. How RIG-I's cytoplasmic localization reconciles with the nuclear replication nature of IAV is poorly understood. Recent findings provide advanced insights into the spatiotemporal RIG-I sensing of IAV and highlight the contribution of various RNA ligands to RIG-I activation. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.02299-18
Publisher Site
http://dx.doi.org/10.1128/JVI.02299-18DOI Listing
February 2019
3 Reads

Adaptation of an R5 Simian-human Immunodeficiency Virus Encoding an HIV Clade A Envelope With or Without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA

Simian-human immunodeficiency virus (SHIV) infection in rhesus macaques (RMs) resembles human immunodeficiency virus type 1 (HIV-1) infection in humans and serves as a tool to evaluate candidate AIDS vaccines. HIV-1 clade A (HIV-A) predominates in parts of Africa. We constructed an R5 clade A SHIV (SHIV-A; strain SHIV-KNH1144) carrying from a Kenyan HIV-A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02267-18DOI Listing
February 2019
1 Read
4.439 Impact Factor

Dissecting the cell entry pathway of baculovirus by single particle tracking and quantitative electron microscopic analysis.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

The budded virus of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infects insect cells through mainly clathrin-mediated endocytosis. However, the cell entry pathway of AcMNPV remains unclear. In this study, by using population-based analysis of single-virus tracking and electron microscopy, we investigated the internalization, fusion behavior and endocytic trafficking of AcMNPV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00033-19DOI Listing
February 2019

Differential Antibody-Based Immune Response Against Isolated GP1 Receptor-Binding Domains from Lassa and Junín Viruses.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel

There are two predominant subgroups in the family of viruses, the Old-World and the New-World viruses that use distinct cellular receptors for entry. While New-World viruses typically elicit good neutralizing antibody responses, the Old-World viruses generally evade such responses. Antibody based immune responses are directed against the glycoprotein spike complexes that decorate the viruses. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.00090-19
Publisher Site
http://dx.doi.org/10.1128/JVI.00090-19DOI Listing
February 2019
1 Read

Baculovirus IE2 interacts with viral DNA through Daxx to generate an organized nuclear body structure for gene activation in Vero cells.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, ROC.

Upon virus infection of a cell, the uncoated DNA is usually blocked by the host intrinsic immune system inside the nucleus. Although it is crucial for the virus to counteract the host intrinsic immune system and access its genome, little is known about how viruses can knock down host restriction and identify their blocked genomes for later viral gene activation and replication. We found that upon baculovirus transduction into Vero E6 cells, the invading viral DNA is trapped by the cellular death domain-associated protein (Daxx) and histone H3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00149-19DOI Listing
February 2019

Conserved gammaherpesvirus protein kinase selectively promotes irrelevant B cell responses.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Microbiology and Immunology Cancer Center Department of Pathology Medical College of Wisconsin, Milwaukee, Wisconsin, USA

Gammaherpesviruses are ubiquitous pathogens that are associated with B cell lymphomas. In the early stages of chronic infection these viruses infect naïve B cells and subsequently usurp the B cell differentiation process through the germinal center response to ensure latent infection of long-lived memory B cells. A unique feature of early gammaherpesvirus chronic infection is a robust differentiation of irrelevant, virus-nonspecific B cells with reactivities against self and other species' antigens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01760-18DOI Listing
February 2019

Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA

Memory B cells (MBCs) are key determinants of the B cell response to influenza virus infection and vaccination, but the effect of different forms of influenza antigen exposure on MBC populations has received little attention. We analyzed peripheral blood mononuclear cells and plasma collected following human H3N2 influenza infection to investigate the relationship between hemagglutinin-specific antibody production and changes in the size and character of hemagglutinin-reactive MBC populations. Infection produced increased concentrations of plasma IgG reactive to the H3 head of the infecting virus, to the conserved stalk, and to a broad chronological range of H3s consistent with original antigenic sin responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00169-19DOI Listing
February 2019
1 Read

Generation of infectious recombinant human rotaviruses from just 11 cloned cDNAs encoding the rotavirus genome.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

The generation of recombinant group A rotaviruses (RVAs) entirely from cloned cDNAs has been described only for a single animal RVA strain, simian SA11-L2. We recently developed an optimized RVA reverse genetics system based on only RVA cDNAs (11-plasmid system), in which the concentration of cDNA plasmids containing the NSP2 and NSP5 genes is 3- or 5-fold increased in relation to that of the other plasmids. Based on this approach, we generated a recombinant human RVA (HuRVA)-based monoreassortant virus containing the VP4 gene of the simian SA11-L2 virus using the 11-plasmid system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02207-18DOI Listing
February 2019
1 Read

Blocking HIV-1 infection by chromosomal integrative expression of human CD4 on the surface of R0052.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Nebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583

bacteria are potential delivery vehicles for biopharmaceutical molecules because they are well-recognized as safe microorganisms that naturally inhabit the human body. The goal of this study is to employ these lactobacilli to combat human immunodeficiency virus (HIV-1) infection and transmission. By using a chromosomal integration method, we engineered the R0052 strain to display human CD4, the HIV-1 receptor, on the cell surface. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01830-18DOI Listing
February 2019
1 Read

Early human B cell response to Ebola virus in four U.S. survivors of infection.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Departments of Pathology, Microbiology, and Immunology Pediatrics, and The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA

The human B cell response to natural filovirus infections early after recovery is poorly understood. Previous serologic studies suggest that some Ebola virus survivors exhibit delayed antibody responses with low magnitude and quality. Here, we sought to study the population of individual memory B cells induced early in convalescence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01439-18DOI Listing
February 2019
4.439 Impact Factor

Infectious herpes simplex virus in the brainstem is correlated with reactivation in the trigeminal ganglia.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati, OH 45229.

Herpes simplex virus (HSV) establishes latency in neurons of the peripheral and central nervous systems (CNS). Evidence is mounting that HSV latency and reactivation in the nervous system has the potential to promote neurodegenerative processes. Understanding how this occurs is an important human health goal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02209-18DOI Listing
February 2019
2 Reads

Comparison of the whole genome sequence of an Oka varicella vaccine from China with other Oka vaccine strains reveals sites putatively critical for vaccine efficacy.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention), WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, People's Republic of China.

Varicella-Zoster Virus (VZV) infection results in varicella mostly in children. Reactivation of the virus causes Herpes Zoster (HZ) mostly in adults. A live attenuated vaccine (vOka-Biken hereafter) was originally derived from the parental strain pOka. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02281-18DOI Listing
February 2019
1 Read

Regulation of HCV infection by Cellular Retinoic Acid Binding Proteins through the modulation of lipid droplet abundance.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

Retinoid (vitamin A) is an essential diet constituent that governs a broad range of biological processes. Its biologically active metabolite, all-trans retinoic acid (ATRA), exhibits a potent antiviral property by enhancing both innate and adaptive antiviral immunity against a variety of viral pathogens such as, but not limited to, HIV, RSV, HSV, and measles. Even though the hepatocyte is highly enriched with retinoid and its metabolite, ATRA, it supports the establishment of efficient hepatitis C virus (HCV) replication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02302-18DOI Listing
February 2019

Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Center for Host-Pathogen Interaction, Columbia University Medical Center, New York, USA

A clinical isolate of measles virus (MeV) bearing a single amino acid alteration in the viral fusion protein (F; L454W) was previously identified in two patients with lethal sequelae of MeV central nervous system (CNS) infection. The mutation dysregulated the viral fusion machinery so that the mutated F protein mediated cell fusion in the absence of known MeV cellular receptors. While this virus could feasibly have arisen via intra-host evolution of the wildtype (wt) virus, it was recently shown that the same mutation emerged under the selective pressure of small molecule antiviral treatment. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.01862-18
Publisher Site
http://dx.doi.org/10.1128/JVI.01862-18DOI Listing
February 2019
5 Reads

Medusavirus, a novel large DNA virus discovered from hot spring water.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku, Tokyo, 162-8601, Japan

Recent discoveries of new large DNA viruses reveal high diversity in their morphologies, genetic repertoires, and replication strategies. Here, we report the novel features of Medusavirus, a large DNA virus newly isolated from hot spring water in Japan. Medusavirus with a diameter of 260 nm shows a T=277 icosahedral capsid with unique spherical-headed spikes on its surface. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02130-18DOI Listing
February 2019

Human papillomavirus E6/E7 and lncRNA TMPOP2 mutually upregulated gene expression in cervical cancer cells.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Key Laboratory of Industrial Microbiology, Ministry of Education and Tianjin City, Tianjin University of Science and Technology, Tianjin, China

TMPOP2 was previously suggested to be an oncogenic long noncoding RNA which is excessively expressed in cervical cancer cells and inhibits E-cadherin gene expression by recruiting transcription repressor EZH2 to gene promoter. So far, the function and regulation of TMPOP2 in cervical cancer remains largely unknown. Herein, we found that TMPOP2 expression was correlated with human papillomavirus HPV16/18 E6 and E7 in cervical cancer cell CaSki and HeLa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01808-18DOI Listing
February 2019

Hepatitis Delta Antigen Regulates mRNA and Antigenome RNA Levels during Hepatitis Delta Virus Replication.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D.C., USA

Hepatitis delta virus (HDV) is a satellite of hepatitis B virus that increases the severity of acute and chronic liver disease. HDV produces three processed RNAs that accumulate in infected cells: the circular genome, the circular antigenome, which serves as a replication intermediate, and lesser amounts of the mRNA, which encodes the sole viral protein, hepatitis delta antigen (HDAg). The HDV genome and antigenome RNAs form ribonucleoprotein complexes with HDAg. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01989-18DOI Listing
February 2019
1 Read

The DNase Activity of KSHV SOX Protein Serves an Important Role in Viral Genome Processing During Lytic Replication.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Microbiology and Immunology, University of Nevada, Reno, School of Medicine, 1664 N Virginia Street, MS 320, Reno, NV 89557, USA

The KSHV alkaline exonuclease SOX, encoded by ORF37, is a bifunctional, early-lytic phase protein that possesses an alkaline 5'- to 3'- DNase activity and promotes host shutoff at the mRNA level during productive lytic infection. While the SOX protein is well characterized for drastically impairing cellular gene expression, little is known about the impact of its DNase activity on KSHV genome, life cycle and biology of KSHV infections. Here, we introduced a previously described DNase-inactivating Glu129His/Q129H mutation into ORF37 gene of the viral genome to generate ORF37-Q129H recombinant virus (Q129H mutant) and investigated the effects of loss/inactivation of DNase activity on viral genome replication, cleavage and packaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01983-18DOI Listing
February 2019

Coronavirus endoribonuclease activity in porcine epidemic diarrhea virus suppresses type I and type III interferon responses.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA

Identifying viral antagonists of innate immunity and determining if they contribute to pathogenesis is critical for developing effective strategies to control emerging viruses. Previously, we reported that an endoribonuclease (EndoU) encoded by murine coronavirus plays a pivotal role in evasion of host innate immune defenses in macrophages. Here, we asked if the EndoU activity of porcine epidemic diarrhea coronavirus (PEDV), which causes acute diarrhea in swine, plays a role in antagonizing the innate response in porcine epithelial cells and macrophages, the sites of viral replication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02000-18DOI Listing
February 2019
2 Reads

Zika virus infection in causes dermatological manifestations and confers protection against secondary infection.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.

Animal models of Zika virus (ZIKV) infection have recently been established in mice, guinea pigs, and nonhuman primates. Tree shrews () are an emerging experimental animal in biomedical applications, but their susceptibility to ZIKV infection has not been explored. In the present study, we showed that subcutaneous inoculation of ZIKV led to rapid viremia and viral secretion in saliva, as well as to typical dermatological manifestations characterized by massive diffuse skin rash on the trunk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01982-18DOI Listing
February 2019
1 Read

Punctuated evolution of myxoma virus: rapid and disjunct evolution of a recent viral lineage in Australia.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Sydney Medical School, Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.

Myxoma virus (MYXV) has been evolving in a novel host species - European rabbits - in Australia since 1950. Previous studies of viruses sampled from 1950 to 1999 revealed a remarkably clock-like evolutionary process across all Australian lineages of MYXV. Through an analysis of 49 newly generated MYXV genome sequences isolated in Australia between 2008 and 2017 we show that MYXV evolution in Australia can be characterized by three lineages, one of which exhibited a greatly elevated rate of evolutionary change and a dramatic break-down of temporal structure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01994-18DOI Listing
February 2019

The pseudoknots region of the 5' untranslated region is a determinant of viral tropism and virulence of foot-and-mouth disease virus.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China

Foot-and-mouth disease virus (FMDV) is the causative agent of foot-and-mouth disease. It is well-characterized by the genetic instability and different antigenic properties. The nonstructural protein, 3A, is a primary determinant of viral tropism and virulence of Cathay topotype FMDVs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02039-18DOI Listing
February 2019

The 13th International Double-Stranded RNA Virus Symposium, Houffalize, Belgium, 24 to 28 September 2018.

J Virol 2019 Feb 5;93(4). Epub 2019 Feb 5.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

The triennial International Double-Stranded RNA Virus Symposium, this year organized by J. Matthijnssens, J. S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01964-18DOI Listing
February 2019

Arbidol and other Low Molecular Weight Drugs That Inhibit Lassa and Ebola Viruses.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Microbiology and Department of Cell Biology, University of Virginia, Charlottesville, Virginia, 22908

Antiviral therapies that impede virus entry are attractive because they act on the first phase of the infectious cycle. Drugs that target pathways common to multiple viruses are particularly desirable when laboratory-based viral identification may be challenging, e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02185-18DOI Listing
January 2019

Assessing the protective potential of H1N1 influenza virus hemagglutinin head and stalk antibodies in humans.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodies (Abs) elicited by influenza viruses target the head domain of the hemagglutinin (HA) protein. Anti-HA head Abs can be highly potent, but they have limited breadth since the HA head is variable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02134-18DOI Listing
January 2019

The molecular basis for antigenic drift of human A/H2N2 influenza viruses.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands

Influenza A/H2N2 viruses caused a pandemic in 1957 and continued to circulate in humans until 1968. The antigenic evolution of A/H2N2 viruses over time and the amino acid substitutions responsible for this antigenic evolution are not known. Here, the antigenic diversity of a representative set of human A/H2N2 viruses isolated from 1957 until 1968 was characterized. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.01907-18
Publisher Site
http://dx.doi.org/10.1128/JVI.01907-18DOI Listing
January 2019
4 Reads

Identification of NK cell subpopulations that differentiate HIV-infected subject cohorts with diverse level of virus control.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Gilead Sciences, Inc., Foster City, CA, USA

HIV infection is controlled immunologically in a small subset of infected individuals without antiretroviral therapy (ART), though the mechanism of control is unclear. CD8 T cells are a critical component of HIV control in many immunologic controllers. NK cells are also believed to have a role in controlling HIV infection, though their role is less well-characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01790-18DOI Listing
January 2019
1 Read
4.439 Impact Factor

S-like phase CDKs stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcription.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

Temporally controlled gene expression is necessary for the propagation of herpesviruses. To achieve this, herpesviruses encode several transcriptional regulators. In Epstein-Barr virus, BcRF1 associates with five viral proteins (BDLF4, BGLF3, BFRF2, BVLF1 and BDLF3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01707-18DOI Listing
January 2019

An epigenetic journey: Epstein-Barr virus transcribes chromatinized and subsequently unchromatinized templates during its lytic cycle.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, USA.

The Epstein-Barr virus lytic phase, like that of all herpesviruses, proceeds via an orderly cascade that integrates DNA replication and gene expression. EBV early genes are expressed independent of viral DNA amplification, and several early gene products facilitate DNA amplification. On the other hand, EBV late genes are defined by their dependence upon viral DNA replication for expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02247-18DOI Listing
January 2019

Ceramide suppresses influenza A virus replication .

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Lebanon

Annual influenza outbreaks are associated with significant morbidity and mortality worldwide despite the availability of seasonal vaccines. Influenza pathogenesis depends on the manipulation of host cell signaling to promote virus replication. Ceramide is a sphingosine-derived lipid that regulates diverse cellular processes. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.00053-19
Publisher Site
http://dx.doi.org/10.1128/JVI.00053-19DOI Listing
January 2019
3 Reads

GADD45γ activated early in the course of HSV-1 infection suppresses the activation of a network of innate immunity genes.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China

The stress response genes encoding GADD45γ, and to a lesser extent GADD45β are activated early in infection with HSV-1. Cells depleted of GADD45γ by transfection of shRNA or in which the gene had been knocked out (ΔGADD45γ) yield significantly less virus than untreated infected cells. Consistent with lower virus yields the ΔGADD45γ cells, both uninfected or infected with HSV-1 exhibit significantly higher levels of transcripts encoding a cluster of a network of innate immunity genes that include those encoding IFI16, IFIT1, MDA5 and RIG-I. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02201-18DOI Listing
January 2019

An emerging issue in oncogenic virology: the role of beta HPV types in development of cutaneous squamous cell carcinoma.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Infections and Cancer Biology Group, International Agency for Research on Cancer (IARC), Lyon, France

Evidence suggests that beta HPVs, together with ultraviolet radiation, contribute to the development of cutaneous squamous cell carcinoma. Beta HPVs appear to be not the main drivers of carcinogenesis, but rather facilitators of the accumulation of ultraviolet-induced DNA mutations. Beta HPVs are promoters of skin carcinogenesis, although they are dispensable for the maintenance of the malignant phenotype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01003-18DOI Listing
January 2019

Transmission of A Novel Genotype Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

Hepatitis E virus (HEV) is zoonotic and a major cause of acute viral hepatitis worldwide. Recently, we identified a novel HEV genotype 8 (HEV8) in Bactrian camels in Xinjiang, China. However, the epidemiology, pathogenicity and zoonotic potential of HEV8 are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02014-18DOI Listing
January 2019
2 Reads

Engineering Responses to Amino Acid Substitutions in the VP0 and VP3 Coding Regions of PanAsia-1 Strains of Foot-and-Mouth Disease Virus Serotype O.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

State Key Laboratory of Veterinary Etiological Biology, OIE/China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.

The presence of sequence divergence through adaptive mutations in the major capsid protein VP1, and also in VP0 (VP4 and VP2) and VP3 of foot-and-mouth disease virus (FMDV) is relevant to a broad range of viral characteristics. To explore the potential role of isolate-specific residues in the VP0 and VP3 coding regions of PanAsia-1 strains in genetic and phenotypic properties of FMDV, a series of recombinant full-length genomic clones were constructed, by using a Cathay topotype infectious cDNA as the original backbone. The deleterious and compensatory effects of individual amino acid substitutions at positions 4008, 3060, and in several different domains of VP2 illustrated that the chain-based spatial interaction patterns of VP1-3 as well as between the internal VP4 and the three external capsid proteins of FMDV might contribute to the assembly of eventually viable viruses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02278-18DOI Listing
January 2019
1 Read

Expression of the pseudorabies virus gB glycoprotein triggers NK cell cytotoxicity and increases binding of the activating NK cell receptor PILRbeta.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Laboratory of Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

Natural killer (NK) cells are members of the innate immunity and are key players in the defense against viral infected and malignant cells. NK cells are particularly important in the innate defense against herpesviruses, including alphaherpesviruses. Aggravated and life-threatening alphaherpesvirus-induced disease has been reported in patients with NK cell deficiencies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02107-18DOI Listing
January 2019

Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in HIV-1 Chronically Infected Women.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Duke Human Vaccine Institute, Duke University, Durham, NC

The humoral response to invading mucosal pathogens comprises multiple antibody isotypes, derived from systemic and mucosal compartments. To understand the contribution of each antibody isotype/source to the mucosal humoral response, parallel investigation of the specificities and functions of antibodies within and across isotypes and compartments is required. The role of IgA against HIV-1 is complex, with studies supporting a protective role as well as a role for serum IgA in blocking effector functions. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.02084-18
Publisher Site
http://dx.doi.org/10.1128/JVI.02084-18DOI Listing
January 2019
2 Reads

Characterization of intact proviruses in blood and lymph node from HIV-infected individuals undergoing analytical treatment interruption.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA

The role of lymphoid tissue as a potential source of HIV-1 rebound following interruption of antiretroviral therapy is uncertain. To address this issue, we compared the latent viruses obtained from CD4 T cells in peripheral blood and lymph nodes to viruses emerging during treatment interruption. Latent viruses were characterized by sequencing near full-length (NFL) proviral DNA, and from viral outgrowth cultures (VOAs). Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.01920-18
Publisher Site
http://dx.doi.org/10.1128/JVI.01920-18DOI Listing
January 2019
4 Reads

JC Polyomavirus Entry by Clathrin-Mediated Endocytosis is Driven by β-arrestin.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Molecular and Biomedical Sciences, The University of Maine, Orono, ME, USA

JC polyomavirus (JCPyV) establishes a persistent, lifelong, asymptomatic infection within the kidney of the majority of the human population. Under conditions of severe immunosuppression or immune modulation, JCPyV can reactivate in the central nervous system (CNS) and cause progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease. Initiation of infection is mediated through viral attachment to α2,6-sialic acid containing lactoseries tetrasaccharide c (LSTc) on the surface of host cells. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.01948-18
Publisher Site
http://dx.doi.org/10.1128/JVI.01948-18DOI Listing
January 2019
6 Reads

HoxA10 Facilitates SHP-1-catalized Dephosphorylation of p38 MAPK/STAT3 to Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism.

J Virol 2019 Jan 23. Epub 2019 Jan 23.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China

Hepatitis B virus (HBV) infection is the leading cause of chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). This study reveals a distinct mechanism underlying the regulation of HBV replication. HBV activates the homeobox A10 (HoxA10) in human hepatocytes, leukocytes, peripheral blood mononuclear cells (PBMCs), HepG2-NTCP cells, leukocytes isolated from CHB patients, and HBV-associated HCC tissues. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.01607-18
Publisher Site
http://dx.doi.org/10.1128/JVI.01607-18DOI Listing
January 2019
6 Reads
4.439 Impact Factor