236,550 results match your criteria Journal of Vaccines & Vaccination [Journal]


Synthesis and immunological studies of β-1,2-mannan-peptide conjugates as antifungal vaccines.

Eur J Med Chem 2019 Apr 5;173:250-260. Epub 2019 Apr 5.

Department of Chemistry, University of Florida, 214 Leigh Hall, Gainesville, FL, 32611, USA. Electronic address:

Fungal cell surface carbohydrates and proteins are useful antigens for the development of antifungal vaccines. In this study, glycopeptides consisting of the β-1,2-mannan and N-terminal peptide epitopes of Candida albicans (C. albicans) cell wall phosphomannan complex and Als1p (rAls1p-N) protein, respectively, were synthesized and covalently conjugated with keyhole limpet hemocyanin (KLH) and human serum albumin (HSA) through homobifunctional disuccinimidyl glutarate. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.001DOI Listing

Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapy.

J Pharm Biomed Anal 2019 Apr 9;172:1-8. Epub 2019 Apr 9.

Jack Jumper Allergy Program, Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania, 7001, Australia; School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide, South Australia, 5001, Australia.

A major challenge in broader clinical application of Jack Jumper ant venom immunotherapy (JJA VIT) is the scarcity of ant venom which needs to be manually harvested from wild ants. Adjuvants are commonly used for antigen sparing in other vaccines, and thereby could potentially have major benefits to extend JJA supplies if they were to similarly enhance JJA VIT immunogenicity. The purpose of this study was to evaluate the physicochemical and microbiological stability and murine immunogenicity of low-dose JJA VIT formulated with a novel polysaccharide adjuvant referred to as delta inulin or Advax™. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.017DOI Listing

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target.

PLoS Pathog 2019 Apr 22;15(4):e1007713. Epub 2019 Apr 22.

Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. The cell wall-anchored protein clumping factor B (ClfB) has previously been shown to facilitate S. aureus nasal colonization through high affinity interactions with the cornified envelope in the anterior nares. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007713DOI Listing

Detection of post-vaccination enhanced dengue virus infection in macaques: An improved model for early assessment of dengue vaccines.

PLoS Pathog 2019 Apr 22;15(4):e1007721. Epub 2019 Apr 22.

Research & Development, GSK Vaccines, Rixensart, Belgium.

The need for improved dengue vaccines remains since the only licensed vaccine, Dengvaxia, shows variable efficacy depending on the infecting DENV type, and increases the risk of hospitalization for severe dengue in children not exposed to DENV before vaccination. Here, we developed a tetravalent dengue purified and inactivated vaccine (DPIV) candidate and characterized, in rhesus macaques, its immunogenicity and efficacy to control DENV infection by analyzing, after challenge, both viral replication and changes in biological markers associated with dengue in humans. Although DPIV elicited cross-type and long-lasting DENV-neutralizing antibody responses, it failed to control DENV infection. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007721DOI Listing

Assessment on reticuloendotheliosis virus infection in specific-pathogen-free chickens based on detection of yolk antibody.

PLoS One 2019 22;14(4):e0213978. Epub 2019 Apr 22.

College of Veterinary Medicine, Shandong Agricultural University, Taian, China.

Reticuloendotheliosis virus (REV) is the most frequent exogenous virus that contaminates attenuated vaccines. Therefore, it is extremely important to select REV-free specific-pathogen-free (SPF) chicken embryos. Generally, REV infection is assessed by detecting REV antibodies in SPF chickens. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213978PLOS

PARTIAL PROTECTION IN BALB/C HOUSE MICE () AND ROCKY MOUNTAIN ELK () AFTER VACCINATION WITH A KILLED, MUCOSALLY DELIVERED VACCINE.

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

2   Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

Brucellosis, caused by , has been eliminated from livestock in the US. Remaining wildlife reservoirs are the bison () and elk () populations in Yellowstone National Park and the surrounding area, from which there is periodic exposure and transmission to surrounding livestock herds. Elk account for nearly all of the livestock exposure, and the infection appears to be expanding in the elk population. Read More

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Selection of adjuvants for vaccines targeting specific pathogens.

Expert Rev Vaccines 2019 Apr 22:1-17. Epub 2019 Apr 22.

a VIDO-InterVac , University of Saskatchewan , Saskatoon , Canada.

Introduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and adaptive levels such that protective immunity can be elicited. Areas covered: Herein, we describe the recent progress in our understanding of the mode of action of adjuvants that are licensed for use in human vaccines or in clinical or pre-clinical stages at both innate and adaptive levels. Read More

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http://dx.doi.org/10.1080/14760584.2019.1604231DOI Listing

Plasmid copy number of pTRKH3 in Lactococcus lactis is increased by modification of the repDE ribosome binding site.

Biotechnol J 2019 Apr 22:e1800587. Epub 2019 Apr 22.

IBB - Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.

Plasmids for DNA vaccination are exclusively produced in the Gram-negative Escherichia coli. One important drawback of this system is the presence of lipopolysaccharides. The Generally Recognized As Safe Lactococcus lactis would constitute a safer alternative for plasmid production. Read More

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http://dx.doi.org/10.1002/biot.201800587DOI Listing

Duration of Immunity and Effectiveness of Diphtheria-Tetanus-Acellular Pertussis Vaccines in Children.

JAMA Pediatr 2019 Apr 22. Epub 2019 Apr 22.

Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor.

Importance: The United States has experienced a nationwide resurgence of pertussis since the mid-1970s, despite high estimated vaccine coverage. Short-lived immunity induced by diphtheria-tetanus-acellular pertussis (DTaP) vaccines in young children is widely believed to be responsible for this growing burden, but the duration of protection conferred by DTaP vaccines remains incompletely quantified.

Objective: To assess the duration of immunity and the effectiveness of DTaP vaccines in US children. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2019.0711DOI Listing

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses.

J Vis Exp 2019 Apr 4(146). Epub 2019 Apr 4.

UMR 1173 Institut national de la santé et de la recherche médicale (INSERM), Université de Versailles St. Quentin; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Ambroise Paré, Laboratoire de Microbiologie;

The use of recombinant viruses has become crucial in basic or applied virology. Reverse genetics has been proven to be an extremely powerful technology, both to decipher viral replication mechanisms and to study antivirals or provide development platform for vaccines. The construction and manipulation of a reverse genetic system for a negative-strand RNA virus such as a respiratory syncytial virus (RSV), however, remains delicate and requires special know-how. Read More

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http://dx.doi.org/10.3791/59218DOI Listing

The effectiveness and safety of pertussis booster vaccination for adolescents and adults: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15281

Immunization Program Office, Chongqing Center for Disease Control and Prevention.

Background: Due to the resurgence of pertussis, many countries have revised the pertussis immunization schedules and recommended booster doses of pertussis component vaccine for adolescents and adults. Here we aim to investigate the effectiveness and safety of pertussis component vaccines in adolescents and adults.

Methods: Based on a prospectively registered protocol, we reviewed the literature and selected trials in adolescents and adults using pertussis component vaccine. Read More

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http://dx.doi.org/10.1097/MD.0000000000015281DOI Listing

Treatment and Prevention of Pneumococcal Infection.

Clin Obstet Gynecol 2019 Apr 18. Epub 2019 Apr 18.

Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida.

Streptococcus pneumoniae, a gram-positive diplococcus, is the most common cause of bacterial pneumonia. The diagnosis of pneumococcal pneumonia is usually confirmed by chest x-ray and gram stain. The most appropriate antibiotics for treatment pneumococcal infection are macrolides, beta-lactams, and quinolones. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000451DOI Listing

Ovarian Cancer Stem Cells with High ROR1 Expression Serve as a New Prophylactic Vaccine for Ovarian Cancer.

J Immunol Res 2019 17;2019:9394615. Epub 2019 Mar 17.

Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China.

Tumor vaccines offer a number of advantages for cancer treatment. In the study, the vaccination with cancer stem cells (CSCs) with high expression of the type I receptor tyrosine kinase-like orphan receptor (ROR1) was evaluated in a murine model for the vaccine's immunogenicity and protective efficacy against epithelial ovarian carcinoma (EOC). CD117CD44 CSCs were isolated from human EOC HO8910 cell line using a magnetic-activated cell sorting system; murine ID8 EOC suspension sphere cells, which are collectively known as cancer stem-like cells, were acquired from serum-free suspension sphere-forming culture. Read More

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http://dx.doi.org/10.1155/2019/9394615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441513PMC

Evaluation of Different Stabilizers and Inactivating Compounds for the Enhancement of Vero Cell Rabies Vaccine Stability and Immunogenicity: Study.

Biomed Res Int 2019 17;2019:4518163. Epub 2019 Mar 17.

Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Saudi Arabia.

Inactivation of rabies virus is essential for rabies vaccine preparation where the inactivating compound that is currently recommended for rabies vaccine preparation is -propiolactone (-PL). This compound is considered better than phenol and formalin but it is expensive and potentially carcinogenic. Data revealed that Ascorbic acid (AA) with cupric ions could yield complete and irreversible inactivation of rabies virus without adversely affecting its antigenicity. Read More

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http://dx.doi.org/10.1155/2019/4518163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441502PMC

Self-reported receipt of preventive practices and its associated factors among adults with diabetes in the United States.

Prev Med Rep 2019 Jun 30;14:100857. Epub 2019 Mar 30.

Pharmacy Practice Research Unit, College of Pharmacy, Jazan University, Saudi Arabia.

Previous studies indicated that a high proportion of adults with diabetes do not receive recommended preventive care in the United States. Nevertheless, a comprehensive evaluation of the factors associated with the receipt of most recommended preventive care measures collectively is lacking. Therefore, this study describes the utilization of multiple preventive care measures collectively. Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.100857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458492PMC

The shape of chiropractic in Europe: a cross sectional survey of chiropractor's beliefs and practice.

Chiropr Man Therap 2019 10;27:16. Epub 2019 Apr 10.

AECC University College, Parkwood Road, Bournemouth, England, UK.

Background: The chiropractic profession both in the past and presently has diverse opinions concerning different health care approaches and the science or otherwise that underpins them. Previous research has reported that adherence to unorthodox descriptions of chiropractic were associated with types of practice behavior considered outside of acceptable evidence-based guidelines in Canada. However, this type of investigation has not been repeated in a European context and such relationships may be different. Read More

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http://dx.doi.org/10.1186/s12998-019-0237-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456953PMC

Structural Insights for Anti-Influenza Vaccine Design.

Comput Struct Biotechnol J 2019 23;17:475-483. Epub 2019 Mar 23.

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China.

Influenza A virus are a persistent and significant threat to human health, and current vaccines do not provide sufficient protection due to antigenic drift, which allows influenza viruses to easily escape immune surveillance and antiviral drug activity. Influenza hemagglutinin (HA) is a glycoprotein needed for the entry of enveloped influenza viruses into host cells and is a potential target for anti-influenza humoral immune responses. In recent years, a number of broadly neutralizing antibodies (bnAbs) have been isolated, and their relative structural information obtained from the crystallization of influenza antigens in complex with bnAbs has provided some new insights into future influenza vaccine research. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458449PMC

Progress towards elimination of measles in Kenya, 2003-2016.

Pan Afr Med J 2018 28;31:65. Epub 2018 Sep 28.

United States Centers for Disease Control and Prevention, Kenya.

Introduction: Measles is targeted for elimination in the World Health Organization African Region by the year 2020. In 2011, Kenya was off track in attaining the 2012 pre-elimination goal. We describe the epidemiology of measles in Kenya and assess progress made towards elimination. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.65.16309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457729PMC
September 2018

A Multicenter, Randomized, Equivalence Trial of a New Recombinant Human Chorionic Gonadotropin Preparation versus Ovitrelle for Ovulation in Women Undergoing Intrauterine Insemination Following Ovarian Stimulation.

J Hum Reprod Sci 2019 Jan-Mar;12(1):53-58

Department of Clinical Research and Pharmacovigilance, Bharat Serums and Vaccines Limited, Navi Mumbai, Maharashtra, India.

Context: A new indigenous recombinant human chorionic gonadotropin (r-hCG) has been developed in India with a comparable pharmacological profile to that of Ovitrelle (Merck Serono).

Aims: This study aims to compare the efficacy and safety of the new r-hCG with that of Ovitrelle for induction of ovulation in women undergoing intrauterine insemination (IUI).

Settings And Design: Randomized (2:1), multicenter, open-label, equivalence clinical trial conducted in India. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_101_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472201PMC

HBs antigen and mannose loading on the surface of iron oxide nanoparticles in order to immuno-targeting: fabrication, characterization, cellular and humoral immunoassay.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1543-1558

d Recombinant Vaccine Research Center , Tehran University of Medical Sciences , Tehran , Iran.

Mannosylation of nanovaccine is an appropriate strategy for targeting the mannose receptors on DCs. Here, HBsAg and mannose loaded on the surface of iron oxide nanoparticles to increases HBsAg vaccine potency. Nanoparticles are made by co-precipitation method and bonded to the HBsAg and mannose by chemical bonding. Read More

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http://dx.doi.org/10.1080/21691401.2019.1577888DOI Listing
December 2019

[Assessment of the effectiveness of an intervention to improve immunization coverage in splenectomy patients].

Rev Esp Salud Publica 2019 Apr 22;93. Epub 2019 Apr 22.

Servicio de Medicina Preventiva y Salud Pública. Hospital Clínico Universitario Lozano Blesa. Zaragoza. España.

Objective: Splenectomized patients have an increased risk of sepsis caused by encapsulated bacteria. Pneumococcal, meningococcal and Haemophilus influenzae B vaccination is recommended in this group. The aim of our study was to assess the impact of the introduction of an immunization hospital clinic on their immunization coverages. Read More

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[Use of mobile immunization teams to increase influenza vaccination coverage among heatlthcare workers. A community intervention trial].

Rev Esp Salud Publica 2019 Apr 22;93. Epub 2019 Apr 22.

Centre de Salut Ontinyent-III. Ontinyent. Valencia. España.

Objective: The use of mobile immunization teams has been proposed as a strategy to increase influenza vaccination (IV) coverage among healthcare workers (HCW), but has not been evaluated in Primary Healthcare (PHC). The objective of this work was to determine if the use of mobile immunization teams increases IV coverage among HCW of a basic health area in the Valencian Community.

Methods: Community intervention trial that included all HCWs from a basic health area in the Valencian Community. Read More

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Public motives and willingness to participate in first-in-human clinical trials in Saudi Arabia: A new era in the making.

J Infect Public Health 2019 Apr 18. Epub 2019 Apr 18.

King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia. Electronic address:

Background: Participation in first-in-human (FIH) clinical trials is a valuable contribution to science. This study aims to investigate the Saudi public's attitude toward FIH clinical trials, identify their willingness to take part in it, and their preferences for participating in these kinds of trials, given the fact that the Saudi FDA has never approved such studies in Saudi Arabia.

Methods: This was a cross sectional study conducted in February 2018. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.013DOI Listing

Nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies - a comprehensive review.

Vet Q 2019 Dec;39(1):26-55

k National Institute of Virology , Ministry of Health and Family Welfare, Govt of India , Pune , India.

Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservoir host. Read More

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December 2019

[Study on the safety and immunogenicity of simultaneous vaccination on both hepatitis E and hepatitis B vaccines].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):451-456

Beijing Chaoyang District Center for Disease Control and Prevention, Beijing 100021, China.

Safety and immunogenicity regarding simultaneous vaccination on both hepatitis E and hepatitis B vaccines were studied. A total of 600 healthy subjects aged 18-60 were recruited in Chaoyang district of Beijing city, from September 2015 to December 2016. Subjects meeting the inclusion and exclusion criteria were randomly divided into 3 groups: the simultaneous vaccination group of hepatitis E and hepatitis B, the hepatitis B vaccination group and the hepatitis E vaccination group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.015DOI Listing

Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017.

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

Monash University, Melbourne, VIC.

Objectives: To assess variations by time of year and hospital in the uptake of influenza and pertussis vaccinations by pregnant women in Victoria; to identify factors associated with vaccination uptake.

Design, Setting: Retrospective analysis of data in the Victorian Perinatal Data Collection (VPDC), a population surveillance system for obstetric conditions, procedures, and pregnancy and birth outcomes.

Participants: Women whose pregnancies ended in a live or stillbirth during July 2015 - June 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50125
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http://dx.doi.org/10.5694/mja2.50125DOI Listing
April 2019
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MF59 adjuvant enhances the immunogenicity and protective immunity of the OmpK/Omp22 fusion protein from Acineterbacter baumannii through intratracheal inoculation in mice.

Scand J Immunol 2019 Apr 21:e12769. Epub 2019 Apr 21.

Institute of Immunology and Molecular Biology, North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Acinetobacter baumannii (A. baumannii) is an emerging nosocomial pathogenic bacterium which leads to hospital infections. The increase of drug-resistant A. Read More

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http://dx.doi.org/10.1111/sji.12769DOI Listing

Hydrophobic-interaction chromatography for purification of influenza A and B virus.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 1;1117:103-117. Epub 2019 Apr 1.

Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany; Chair of Bioprocess Engineering, Otto-von-Guericke University, 39106 Magdeburg, Germany.

Options for hydrophobic-interaction chromatography (HIC) for purification of cell culture-derived influenza A and B virus have been assessed using a 96-well plate format using a semi-high-throughput approach. Follow-up experiments at preparative scale were used to characterize dynamic binding capacity, viral hemagglutinin protein (HA protein) recovery, and the influence of influenza virus (IV) strains on yield and contamination levels. Virus recoveries of up to 96% with a residual DNA level of about 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232193016
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http://dx.doi.org/10.1016/j.jchromb.2019.03.037DOI Listing
April 2019
1 Read

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study.

Vaccine 2019 Apr 17. Epub 2019 Apr 17.

Division of Infectious Diseases, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea; The Research Institute of Emerging Infectious Diseases, Korea University, Seoul, Republic of Korea. Electronic address:

Background: While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.

Methods: For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.04.017DOI Listing

Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1.

Vaccine 2019 Apr 17. Epub 2019 Apr 17.

Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering, Sandtorstr. 1, 39106 Magdeburg, Germany; Chair for Bioprocess Engineering, Otto-von-Guericke-University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany.

Seasonal and pandemic influenza respiratory infections are still a major public health issue. Vaccination is the most efficient way to prevent influenza infection. One option to produce influenza vaccines is cell-culture based virus propagation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193048
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http://dx.doi.org/10.1016/j.vaccine.2019.04.030DOI Listing
April 2019
2 Reads

HPV-specific antibodies at the oral cavity up to 30 months after the start of vaccination with the quadrivalent HPV vaccine among mid-adult aged men.

Vaccine 2019 Apr 17. Epub 2019 Apr 17.

Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Background: HPV-16 and HPV-18 cause most oropharyngeal cancers, which are increasing in incidence among males. Although HPV vaccines are highly effective against a number of HPV-associated cancers, efficacy for oropharyngeal cancers has not yet been demonstrated. In addition, the level of antibodies required for protection against oral HPV infection is unknown. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.064DOI Listing

Vaccination of the Stem Cell Transplant Recipient and the Hematologic Malignancy Patient.

Infect Dis Clin North Am 2019 Jun;33(2):593-609

Infectious Disease Service, Department of Medicine, Weill Cornell Medical College, 275 York Avenue, Box 420, New York, NY 10065, USA.

Patients with hematologic malignancy or those who undergo hematopoietic stem cell transplantation experience variable degrees of immunosuppression, dependent on underlying disease, therapy received, time since transplant, and complications, such as graft-versus-host disease. Vaccination is an important strategy to mitigate onset and severity of certain vaccine-preventable illnesses, such as influenza, pneumococcal disease, or varicella zoster infection, among others. This article highlights vaccines that should and should not be used in this patient population and includes general guidelines for timing of vaccination administration and special considerations in the context of newer therapies, recent vaccine developments, travel, and considerations for household contacts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915520193001
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http://dx.doi.org/10.1016/j.idc.2019.02.007DOI Listing

Immunogenic evaluation of FMD virus immuno-dominant epitopes coupled with IL-2/FcIgG in BALB/c mice.

Microb Pathog 2019 Apr 17. Epub 2019 Apr 17.

Razi Vaccine and Serum Research Institute, Mashhad, Iran.

Previous studies on vaccine development against foot-and-mouth disease (FMD) virus reported that application of the inactivated vaccines for FMD virus is not completely effective. Novel vaccinations based on immune-dominant epitopes showed they induced immune responses. In addition, for better and safer immunization, access to of efficient adjuvants against FMD virus seems to be critical. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183075
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http://dx.doi.org/10.1016/j.micpath.2019.04.019DOI Listing
April 2019
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Immunization of mice by the co-administration of codon-optimized HPV16 E7 and lL12 genes against HPV16-associated cervical cancer.

Microb Pathog 2019 Apr 17. Epub 2019 Apr 17.

Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address:

Background: Various promising procedures have been used to improve the potency of DNA vaccines for the treatment of human papillomavirus type 16 (HPV16) infections. Interleukin-12 (IL12) is a powerful adjuvant that can contribute to T cell-mediated protection against many pathogens, specifically viruses. Considering the important role of T cell-mediated immunity in tumor clearance, the induction of these responses can help control the progression of tumors in animal models. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.028DOI Listing

A TaqMan probe-based real-time PCR to differentiate porcine epidemic diarrhea virus virulent strains from attenuated vaccine strains.

Mol Cell Probes 2019 Apr 17. Epub 2019 Apr 17.

College of Animal Medicine, Hebei Agricultural University, Baoding, Hebei, 071000, China. Electronic address:

Porcine epidemic diarrhea virus (PEDV) is an important pathogen causing severe watery diarrhea, vomiting, dehydration, and death in sucking piglets. Attenuated vaccines have been used widely in sows in order to protect piglets through passive lactogenic immunity. Rapid and sensitive detection methods for differentiating attenuated vaccine strains from virulent ones are essential and practical in PEDV prevention and control. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.04.003DOI Listing

Development of a novel multiplex electrochemiluminescent-based immunoassay to aid enterotoxigenic Escherichia coli vaccine development and evaluations.

J Immunol Methods 2019 Apr 17. Epub 2019 Apr 17.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of bacterial diarrhea both among children in low and middle income countries and in travelers to these regions. Although there are several approaches to develop an effective vaccine for ETEC, no licensed vaccines are currently available. The most advanced ETEC vaccine candidates include multiple colonization factors along with the heat labile toxin B subunit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00221759183040
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http://dx.doi.org/10.1016/j.jim.2019.04.003DOI Listing
April 2019
1 Read

Timing of Intradermal Rabies Pre-exposure Prophylaxis Injections: Immunological Effect on Vaccination Response.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Travel Clinic, Centre for Infectious Diseases, Military Hospital Queen Astrid, Rue Bruyn 1, 1120 Neder-Over-Heembeek, Belgium.

Introduction: Rabies remains a global threat, with annually over 59,000 deaths. Intradermal (ID) pre-exposure prophylaxis (PrEP) is very efficient and reduces the need for rabies immunoglobulins. Not much is known about factors that influence the immune response to ID administered rabies vaccine. Read More

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http://dx.doi.org/10.1093/milmed/usz048DOI Listing

Postvaccination Febrile Seizure Severity and Outcome.

Pediatrics 2019 Apr 19. Epub 2019 Apr 19.

National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Sydney, Australia.

Background: Febrile seizures (FSs) are a common pediatric condition caused by a sudden rise in temperature, affecting 3% to 5% of children aged ≤6 years. Although vaccination can cause FSs, little is known on whether FSs occurring in the time soon after vaccination (vaccine-proximate febrile seizures [VP-FSs] differ clinically from non-vaccine-proximate febrile seizures [NVP-FSs]). We compared the clinical profile and outcomes of VP-FS to NVP-FS. Read More

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http://dx.doi.org/10.1542/peds.2018-2120DOI Listing
April 2019
6 Reads

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine.

Sci Immunol 2019 Apr;4(34)

HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of B cell expansion and evolution at the single-cell level after vaccination with a replication-competent adenovirus type 4 recombinant virus expressing influenza H5 hemagglutinin. Fluorescent H1 or H5 probes were used to quantitate and isolate peripheral blood B cells and their antigen receptors. Read More

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http://dx.doi.org/10.1126/sciimmunol.aau2710DOI Listing

Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice.

J Immunol 2019 Apr 19. Epub 2019 Apr 19.

Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242;

Respiratory syncytial virus (RSV) is the leading cause of severe respiratory tract infection in infants and young children, but no vaccine is currently available. Live-attenuated vaccines represent an attractive immunization approach; however, balancing attenuation while retaining sufficient immunogenicity and efficacy has prevented the successful development of such a vaccine. Recently, a recombinant RSV strain lacking the gene that encodes the matrix (M) protein (RSV M-null) was developed. Read More

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http://dx.doi.org/10.4049/jimmunol.1900050DOI Listing
April 2019
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International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact.

EBioMedicine 2019 Apr 16. Epub 2019 Apr 16.

Parasites and microbes, Wellcome Sanger Institute, Hinxton, UK.

Background: Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern. We used whole genome sequencing to study pneumococcal serotype, antibiotic resistance and invasiveness, in the context of genetic background.

Methods: Our dataset of 13,454 genomes, combined with four published genomic datasets, represented Africa (40%), Asia (25%), Europe (19%), North America (12%), and South America (5%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193025
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http://dx.doi.org/10.1016/j.ebiom.2019.04.021DOI Listing
April 2019
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Validation of parental reports of rotavirus vaccination of their children compared to the national immunization registry.

Vaccine 2019 Apr 16. Epub 2019 Apr 16.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. Electronic address:

Background: The introduction of rotavirus vaccines into national immunization programs necessitates vaccine effectiveness evaluations. Parental report of vaccination status is a simple and accessible source of information; however, its validity is unclear.

Aims: To validate parental reports of rotavirus immunization compared to documentation of vaccination in national immunization registry, and to assess vaccine effectiveness by each method. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193049
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http://dx.doi.org/10.1016/j.vaccine.2019.04.037DOI Listing
April 2019
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Two similar commercial live attenuated AMPV vaccines prepared by random passage of the identical field isolate, have unrelated sequences.

Vaccine 2019 Apr 16. Epub 2019 Apr 16.

Department of Infection Biology, University of Liverpool, Leahurst Campus, Neston, Cheshire CH64 7TE, United Kingdom.

Since late '80 s Avian metapneumovirus subtype A causes sufficient disease in Europe for commercial companies to have started developing live attenuated vaccines. Here, two of those vaccines were fully consensus sequenced alongside their progenitor field strain (#8544). Sequences comparison shows that the attenuation of field strain #8544 was associated with no common substitutions between the two derived vaccines. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.04.036DOI Listing

Production and Biomedical Application of Flavivirus-like Particles.

Trends Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Department of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland. Electronic address:

Many viruses belonging to the Flaviviridae family are transmitted by invertebrate vectors. Among those transmitted by mosquitos, there are many human pathogens of great medical importance, such as Japanese encephalitis virus, West Nile virus, dengue virus, Zika virus, or yellow fever virus. Millions of people contract mosquito-borne diseases each year, leading to thousands of deaths. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677799193007
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http://dx.doi.org/10.1016/j.tibtech.2019.03.013DOI Listing
April 2019
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CD20-Mimotope Peptides: A Model to Define the Molecular Basis of Epitope Spreading.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Biomedical Sciences and Human Oncology (DIMO), Rheumatologic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, I-70124 Bari, Italy.

Antigen-mimicking peptide (mimotope)-based vaccines are one of the most promising forms of active-immunotherapy. The main drawback of this approach is that it induces antibodies that react poorly with the nominal antigen. The aim of this study was to investigate the molecular basis underlying the weak antibody response induced against the naïve protein after peptide vaccination. Read More

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https://www.mdpi.com/1422-0067/20/8/1920
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http://dx.doi.org/10.3390/ijms20081920DOI Listing
April 2019
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Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection.

Pharmaceutics 2019 Apr 18;11(4). Epub 2019 Apr 18.

Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x virus-like particles (VLP)) as a cross-protective influenza vaccine candidate. Co-delivery of influenza split vaccine and M2e5x VLP to the skin by MN patch was found to confer effective protection against heterosubtypic influenza virus by preventing weight loss and reducing lung viral loads. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040188DOI Listing

Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine.

Curr Opin Immunol 2019 Apr 16;59:42-48. Epub 2019 Apr 16.

Departments of Pedatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States. Electronic address:

Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk populations. VZV-specific immune responses induced by RZV, including the generation of polyfunctional T cells, are driven by the synergistic actions of the components of the vaccine adjuvant system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09527915183017
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http://dx.doi.org/10.1016/j.coi.2019.02.009DOI Listing
April 2019
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Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 T cells.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands. Electronic address:

Outer membrane vesicles (OMVs) are vesicular nano-particles produced by Gram-negative bacteria that are recently being explored as vaccine vector. The fact that OMVs can be efficiently produced by a hypervesiculating Salmonella typhimurium strain, are packed with naturally-occurring adjuvants like lipopolysaccharides (LPS), and can be engineered to express any antigen of choice, makes them ideal candidates for vaccinology. However, it is unclear whether OMVs induce dendritic cell (DC)-mediated antigen-specific T cell responses and how immune activation is coordinated. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.033DOI Listing

Phylogenetic analysis of partial pre-membrane and envelope sequences of dengue viruses circulating in India.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Dept. of Clinical Virology, Christian Medical College, Vellore 632004, Tamil Nadu, India. Electronic address:

Objective: Phylogenetic characteristics of circulating Indian dengue viruses (DENV) were analysed using partial pre-membrane (PrM) and envelope (E) sequences. An immunodominant region was analysed for mutations and alignment with common DENV PCR primers and probes was determined.

Methods: Published Indian PrM and E DENV sequences were analysed with hitherto unpublished PrM sequences from this study site. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.010DOI Listing