243 results match your criteria Journal of Transplantation [Journal]


Renal Dysfunction after Living-Donor Liver Transplantation: Experience with 500 Cases.

J Transplant 2018 23;2018:5910372. Epub 2018 Dec 23.

Liver Transplantation Unit and Gastroenterology Center, Faculty of Medicine, University of Mansoura, Mansoura, Egypt.

The possible risk factors for chronic kidney disease in transplant recipients have not been thoroughly investigated after living-donor liver transplantation. A retrospective cohort study of consecutive adults who underwent living-donor liver transplantation between May 2004 and October 2016, in a single center, was conducted. Kidney function was investigated successively for all the patients throughout the study period, with 12 months being the shortest follow-up. Read More

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http://dx.doi.org/10.1155/2018/5910372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323484PMC
December 2018
6 Reads

Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation.

J Transplant 2018 8;2018:9205083. Epub 2018 Nov 8.

Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada.

Background: Recent changes in the demographic of cardiac donors and recipients have modulated the rate and risk, associated with posttransplant diabetes mellitus (PTDM). We investigated the secular trends of the risk of PTDM at 1 year and 3 years after transplantation over 30 years and explored its effect on major outcomes.

Methods: Three hundred and three nondiabetic patients were followed for a minimum of 36 months, after a first cardiac transplantation performed between 1983 and 2011. Read More

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https://www.hindawi.com/journals/jtrans/2018/9205083/
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http://dx.doi.org/10.1155/2018/9205083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250037PMC
November 2018
5 Reads

Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?

J Transplant 2018 1;2018:6492034. Epub 2018 Oct 1.

Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Survivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology. On the other hand, it could be a useful molecule to be positively targeted when trying to save tissue and promote cells viability. Since protecting the allograft from ischemia reperfusion injury and inflammation-induced damage is a considerable objective in transplantation, it is reasonable to take advantage from antiapoptotic agents like survivin in order to achieve this goal. Read More

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https://www.hindawi.com/journals/jtrans/2018/6492034/
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http://dx.doi.org/10.1155/2018/6492034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188762PMC
October 2018
5 Reads

Optimal Use of Ganciclovir and Valganciclovir in Transplanted Patients: How Does It Relate to the Outcome?

J Transplant 2018 17;2018:8414385. Epub 2018 Sep 17.

Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: Organ transplant recipients receive immunosuppressive regimens to prevent transplant rejection, which put them at increased risk for opportunistic infections like cytomegalovirus (CMV). Ganciclovir and Valganciclovir are mostly used to prevent or treat CMV. Any incorrect use of the drug may have serious consequences for patients. Read More

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http://dx.doi.org/10.1155/2018/8414385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167560PMC
September 2018
1 Read

The Utility of Intraoperative Near Infrared Fluorescence (NIR) Imaging with Indocyanine Green (ICG) for the Assessment of Kidney Allograft Perfusion.

J Transplant 2018 19;2018:6703056. Epub 2018 Aug 19.

Department of Urology, Singapore General Hospital, Singapore.

Background: Near infrared light (NIR) fluorescence imaging with indocyanine green (ICG) has been used in various aspects of surgery, such as in the assessment of vascular anastomosis, tissue perfusion, and the identification of lymph nodes. In this study we evaluated the utility of NIR/ICG fluorescence imaging in kidney transplantation.

Materials And Methods: NIR/ICG imaging was used to assess allograft perfusion in n=1 living donor (LDRT) and n=2 deceased donor (DDRT) renal transplantations, performed in February 2017. Read More

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http://dx.doi.org/10.1155/2018/6703056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120275PMC
August 2018
9 Reads

Establishing Hematopoietic Stem Cell Transplant Unit in Resource Limited Setting: A Critical Analysis of Indian Council of Medical Research 2017 Guidelines.

J Transplant 2018 8;2018:1292307. Epub 2018 Aug 8.

Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, India.

The scope and application of hematopoietic stem cell transplantation are increasing. With advancement in science and close cooperation of health centers, HSCT units are coming up in new developing and underdeveloped countries. India hosts many HSCT units and often provides financially viable option for HSCT to foreign patients as well. Read More

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http://dx.doi.org/10.1155/2018/1292307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106904PMC

Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians.

J Transplant 2018 1;2018:9429265. Epub 2018 Aug 1.

RIPAS Hospital, Bandar Seri Begawan BA1710, Brunei Darussalam.

Drug-induced hematological cytopenia is common in kidney transplantation. Various cytopenia including leucopenia (neutropenia), thrombocytopenia, and anemia can occur in kidney transplant recipients. Persistent severe leucopenia or neutropenia can lead to opportunistic infections of various etiologies. Read More

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http://dx.doi.org/10.1155/2018/9429265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093016PMC
August 2018
1 Read

Does Rabbit Antithymocyte Globulin (Thymoglobuline®) Have a Role in Avoiding Delayed Graft Function in the Modern Era of Kidney Transplantation?

Authors:
Lluís Guirado

J Transplant 2018 12;2018:4524837. Epub 2018 Jul 12.

Department of Renal Transplantation, Fundació Puigvert, Barcelona, Spain.

Delayed graft function (DGF) increases the risk of graft loss by up to 40%, and recent developments in kidney donation have increased the risk of its occurrence. Lowering the risk of DGF, however, is challenging due to a complicated etiology in which ischemia-reperfusion injury (IRI) leads to acute tubular necrosis. Among various strategies explored, the choice of induction therapy is one consideration. Read More

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http://dx.doi.org/10.1155/2018/4524837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077603PMC
July 2018
11 Reads

Ramadan Fasting in Kidney Transplant Recipients: A Single-Centre Retrospective Study.

J Transplant 2018 3;2018:4890978. Epub 2018 Jun 3.

Department of Kidney and Pancreas Transplantation, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Background: Fasting during the lunar month of Ramadan is mandatory to all healthy adult Muslims. Renal transplant recipients are often worried about the impact of fluid and electrolyte deprivation during fasting on the function of their allograft. We aimed to examine the effect of fasting Ramadan on the graft function in renal transplant recipients. Read More

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http://dx.doi.org/10.1155/2018/4890978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008647PMC
June 2018
4 Reads

Renal Transplants from Older Deceased Donors: Use of Preimplantation Biopsy and Differential Allocation to Dual or Single Kidney Transplant according to Histological Score Has No Advantages over Allocation to Single Kidney Transplant by Simple Clinical Indication.

J Transplant 2018 16;2018:4141756. Epub 2018 May 16.

Division of Nephrology, Dialysis and Kidney Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Background: Grafts from elderly donors (ECD) are increasingly allocated to single (SKT) or dual (DKT) kidney transplantation according to biopsy score. Indications and benefits of either procedure lack universal agreement.

Methods: A total of 302 ECD-transplants in period from Jan 1, 2000, to Dec 31, 2015, were allocated to SKT (SKT) on clinical grounds alone (before Dec 2010, pre-DKT era, = 170) or according to a clinical-histological protocol (after Dec 2010, DKT era, = 132) to DKT ( = 48), SKT biopsy-based protocol ("high-risk", SKT, = 51), or SKT clinically based protocol ("low-risk", SKT, = 33). Read More

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http://dx.doi.org/10.1155/2018/4141756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976897PMC
May 2018
7 Reads

Pilot Analysis of Late Conversion to Belatacept in Kidney Transplant Recipients for Biopsy-Proven Chronic Tacrolimus Toxicity.

J Transplant 2018 2;2018:1968029. Epub 2018 May 2.

Massachusetts General Hospital, Boston, MA, USA.

Background: Calcineurin inhibitors are associated with chronic nephrotoxicity, manifesting as interstitial fibrosis/tubular atrophy (IF/TA) and arteriolar hyalinosis. Conversion from tacrolimus to belatacept may be one strategy to preserve renal function.

Methods: We conducted a retrospective review of renal transplant patients followed at our institution who were converted to belatacept and found to have chronic tacrolimus toxicity on biopsy. Read More

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http://dx.doi.org/10.1155/2018/1968029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954857PMC

The Kinetics of Anti-HLA Antibodies in the First Year after Kidney Transplantation: In Whom and When Should They Be Monitored?

J Transplant 2018 23;2018:8316860. Epub 2018 Apr 23.

Renal Transplantation Service, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, SP, Brazil.

The impact of the kinetics of the anti-HLA antibodies after KTx on the occurrence of acute rejection as well as the better time-point to monitor anti-HLA Abs after transplantation is not completely defined. This prospective study followed 150 patients over 12 months after transplantation. Serum IgG anti-HLA Abs were detected by single antigen beads after typing donors and recipients for loci A, B, C, DR, and DQ. Read More

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http://dx.doi.org/10.1155/2018/8316860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937436PMC
April 2018
7 Reads

Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation.

J Transplant 2018 2;2018:8926786. Epub 2018 Apr 2.

Department of Surgery, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

Background: Focal segmental glomerulosclerosis (FSGS) often develops rapidly and frequently progresses to renal failure, while the recurrence rate after kidney transplantation is 20-50%. We performed low-density lipoprotein (LDL) apheresis before kidney transplantation in FSGS patients to prevent recurrence.

Methods: Five adult patients with chronic renal failure due to FSGS undergoing living related donor kidney transplantation were investigated retrospectively. Read More

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http://dx.doi.org/10.1155/2018/8926786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901999PMC
April 2018
9 Reads

Role of Direct Antiviral Agents in Treatment of Chronic Hepatitis C Infection in Renal Transplant Recipients.

J Transplant 2018 28;2018:7579689. Epub 2018 Mar 28.

Army Hospital Research & Referral, Delhi, India.

Background: Since the introduction of direct antiviral agents (DAAs), morbidity of HCV has considerably decreased but still no guidelines have been formulated in renal transplant recipients (RTRs). We studied efficacy and tolerability of direct antiviral agents in RTRs.

Methods: This prospective observational study was conducted at Army Hospital Research & Referral, Delhi, from June 2016 to May 2017. Read More

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http://dx.doi.org/10.1155/2018/7579689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896212PMC
March 2018
4 Reads

Mending a Broken Heart: Treatment of Stress-Induced Heart Failure after Solid Organ Transplantation.

J Transplant 2018 18;2018:9739236. Epub 2018 Feb 18.

Division of Abdominal Transplantation and Hepatobiliary Surgery, Baylor College of Medicine, 6620 Main Street, Suite 1425, Houston, TX 77030, USA.

Stress-induced heart failure, also known as Broken Heart Syndrome or Takotsubo Syndrome, is a phenomenon characterized as rare but well described in the literature, with increasing incidence. While more commonly associated with postmenopausal women with psychiatric disorders, this entity is found in the postoperative patient. The nonischemic cardiogenic shock manifests as biventricular failure with significant decreases in ejection fraction and cardiac function. Read More

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http://dx.doi.org/10.1155/2018/9739236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835255PMC
February 2018
3 Reads

Corticosteroid Weaning in Stable Heart Transplant Patients: Guidance by Serum Cortisol Level.

J Transplant 2018 18;2018:3740395. Epub 2018 Feb 18.

Heart Failure Treatment and Transplant Program, Newark Beth Israel Medical Center, Newark, NJ, USA.

Background: Despite earlier studies describing the feasibility of steroid weaning in heart transplant patients, the majority of patients are maintained on steroid therapy for life. We examined a strategy based on a single morning serum cortisol measurement.

Methods: We assigned stable posttransplant patients, who were maintained on tacrolimus, mycophenolate mofetil, and corticosteroids, into one of two groups based on a screening morning cortisol level. Read More

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http://dx.doi.org/10.1155/2018/3740395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835262PMC
February 2018
1 Read

Management Strategies for Posttransplant Diabetes Mellitus after Heart Transplantation: A Review.

J Transplant 2018 29;2018:1025893. Epub 2018 Jan 29.

Faculty of Medicine, St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.

Posttransplant diabetes mellitus (PTDM) is a well-recognized complication of heart transplantation and is associated with increased morbidity and mortality. Previous studies have yielded wide ranging estimates in the incidence of PTDM due in part to variable definitions applied. In addition, there is a limited published data on the management of PTDM after heart transplantation and a paucity of studies examining the effects of newer classes of hypoglycaemic drug therapies. Read More

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http://dx.doi.org/10.1155/2018/1025893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829348PMC
January 2018
3 Reads

Validation of a Survey Questionnaire on Organ Donation: An Arabic World Scenario.

J Transplant 2018 8;2018:9309486. Epub 2018 Feb 8.

Trauma & Vascular Surgery, Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar.

Objective: To validate a questionnaire for measuring factors influencing organ donation and transplant.

Methods: The constructed questionnaire was based on the theory of planned behavior by Ajzen Icek and had 45 questions including general inquiry and demographic information. Four experts on the topic, Arabic culture, and the Arabic and English languages established content validity through review. Read More

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http://dx.doi.org/10.1155/2018/9309486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822804PMC
February 2018
2 Reads

Analysis of Risk Factors for Kidney Retransplant Outcomes Associated with Common Induction Regimens: A Study of over Twelve-Thousand Cases in the United States.

J Transplant 2017 24;2017:8132672. Epub 2017 Sep 24.

Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL, USA.

We studied registry data of 12,944 adult kidney retransplant recipients categorized by induction regimen received into antithymocyte globulin (ATG) ( = 9120), alemtuzumab ( = 1687), and basiliximab ( = 2137) cohorts. We analyzed risk factors for 1-year acute rejection (AR) and 5-year death-censored graft loss (DCGL) and patient death. Compared with the reference, basiliximab: (1) one-year AR risk was lower with ATG in retransplant recipients of expanded criteria deceased-donor kidneys (HR = 0. Read More

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https://www.hindawi.com/journals/jtrans/2017/8132672/
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http://dx.doi.org/10.1155/2017/8132672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632904PMC
September 2017
5 Reads

Retrospective Study Looking at Cinacalcet in the Management of Hyperparathyroidism after Kidney Transplantation.

J Transplant 2017 13;2017:8720283. Epub 2017 Mar 13.

Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.

The primary objective of this study is to evaluate the use of cinacalcet in the management of hyperparathyroidism in kidney transplant recipients. The secondary objective is to identify baseline factors that predict cinacalcet use after transplantation. In this single-center retrospective study, we conducted a chart review of all patients having been transplanted from 2003 to 2012 and having received cinacalcet up to kidney transplantation and/or thereafter. Read More

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http://dx.doi.org/10.1155/2017/8720283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366779PMC
March 2017
17 Reads

The CECARI Study: Everolimus (Certican®) Initiation and Calcineurin Inhibitor Withdrawal in Maintenance Heart Transplant Recipients with Renal Insufficiency: A Multicenter, Randomized Trial.

J Transplant 2017 20;2017:6347138. Epub 2017 Feb 20.

Department of Cardiology, University Hospitals Leuven, 3000 Leuven, Belgium.

In this 3-year, open-label, multicenter study, 57 maintenance heart transplant recipients (>1 year after transplant) with renal insufficiency (eGFR 30-60 mL/min/1.73 m) were randomized to start everolimus with CNI withdrawal ( = 29) or continue their current CNI-based immunosuppression ( = 28). The primary endpoint, change in measured glomerular filtration rate (mGFR) from baseline to year 3, did not differ significantly between both groups (+7. Read More

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http://dx.doi.org/10.1155/2017/6347138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337890PMC
February 2017
30 Reads

Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored.

J Transplant 2017 26;2017:5646858. Epub 2017 Jan 26.

Department of Nephrology, Hospital del Salvador, Santiago de Chile, Chile; Faculty of Medicine, Universidad de Chile, Santiago de Chile, Chile.

. Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch. Read More

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http://dx.doi.org/10.1155/2017/5646858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299171PMC
January 2017
13 Reads

A Single Perioperative Injection of Dexamethasone Decreases Nausea, Vomiting, and Pain after Laparoscopic Donor Nephrectomy.

J Transplant 2017 22;2017:3518103. Epub 2017 Jan 22.

Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.

A single dose of perioperative dexamethasone (8-10 mg) reportedly decreases postoperative nausea, vomiting, and pain but has not been widely used in laparoscopic donor nephrectomy (LDN). We performed a retrospective cohort study of living donors who underwent LDN between 2013 and 2015. Donors who received a lower dose (4-6 mg)  ( = 70) or a higher dose (8-14 mg) of dexamethasone ( = 100) were compared with 111 donors who did not receive dexamethasone (control). Read More

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http://dx.doi.org/10.1155/2017/3518103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292178PMC
January 2017
4 Reads

Risk Balancing of Cold Ischemic Time against Night Shift Surgery Possibly Reduces Rates of Reoperation and Perioperative Graft Loss.

J Transplant 2017 19;2017:5362704. Epub 2017 Jan 19.

General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany; Core Facility Quality Management & Health Technology Assessment in Transplantation, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.

This retrospective cohort study evaluates the advantages of risk balancing between prolonged cold ischemic time (CIT) and late night surgery. 1262 deceased donor kidney transplantations were analyzed. Multivariable regression was used to determine odds ratios (ORs) for reoperation, graft loss, delayed graft function (DGF), and discharge on dialysis. Read More

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http://dx.doi.org/10.1155/2017/5362704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288530PMC
January 2017
11 Reads

Blood Transfusions and Tumor Biopsy May Increase HCC Recurrence Rates after Liver Transplantation.

J Transplant 2017 5;2017:9731095. Epub 2017 Jan 5.

Department of General, Visceral and Transplantation Surgery, Charité Campus Virchow, Berlin, Germany.

Beneath tumor grading and vascular invasion, nontumor related risk factors for HCC recurrence after liver transplantation (LT) have been postulated. Potential factors were analyzed in a large single center experience. This retrospective analysis included 336 consecutive patients transplanted for HCC. Read More

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http://dx.doi.org/10.1155/2017/9731095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244021PMC
January 2017
10 Reads

Pretransplant Factors and Associations with Postoperative Respiratory Failure, ICU Length of Stay, and Short-Term Survival after Liver Transplantation in a High MELD Population.

J Transplant 2016 17;2016:6787854. Epub 2016 Nov 17.

Banner Transplant and Advanced Liver Disease Center, University of Arizona College of Medicine, Phoenix, AZ, USA; Division of Gastroenterology, Banner University Medical Center, University of Arizona College of Medicine, Phoenix, AZ, USA.

Changes in distribution policies have increased median MELD at transplant with recipients requiring increasing intensive care perioperatively. We aimed to evaluate association of preoperative variables with postoperative respiratory failure (PRF)/increased intensive care unit length of stay (ICU LOS)/short-term survival in a high MELD cohort undergoing liver transplant (LT). Retrospective analysis identified cases of PRF and increased ICU LOS with recipient, donor, and surgical variables examined. Read More

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http://dx.doi.org/10.1155/2016/6787854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131244PMC
November 2016
23 Reads

Immunomodulatory Role of Mesenchymal Stem Cell Therapy in Vascularized Composite Allotransplantation.

J Transplant 2016 16;2016:6951693. Epub 2016 Oct 16.

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Phoenix, AZ, USA; Head and Neck Regeneration Program, Mayo Clinic Center for Regenerative Medicine, Phoenix, AZ, USA.

This review aims to summarize contemporary evidence of the in vitro and in vivo immunomodulatory effects of mesenchymal stem cells (MSCs) in promoting vascularized composite allotransplant (VCA) tolerance. An extensive literature review was performed to identify pertinent articles of merit. Prospective preclinical trials in mammal subjects receiving VCA (or skin allograft) with administration of MSCs were reviewed. Read More

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http://dx.doi.org/10.1155/2016/6951693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086388PMC
October 2016
8 Reads

Everolimus and Malignancy after Solid Organ Transplantation: A Clinical Update.

J Transplant 2016 11;2016:4369574. Epub 2016 Oct 11.

Department of Cardiac Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Malignancy after solid organ transplantation remains a major cause of posttransplant mortality. The mammalian target of rapamycin (mTOR) inhibitor class of immunosuppressants exerts various antioncogenic effects, and the mTOR inhibitor everolimus is licensed for the treatment of several solid cancers. In kidney transplantation, evidence from registry studies indicates a lower rate of malignancy under mTOR inhibition, with some potentially supportive data from randomized trials of everolimus. Read More

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http://dx.doi.org/10.1155/2016/4369574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078653PMC
October 2016
8 Reads

Utilization of Public Health Service Increased Risk Donors Yields Equivalent Outcomes in Liver Transplantation.

J Transplant 2016 29;2016:9658904. Epub 2016 Sep 29.

Department of General Surgery, Division of Abdominal Transplantation, Rush University Medical Center, Chicago, IL, USA.

. The PHS increased risk donor (IRD) is underutilized in liver transplantation. We aimed to examine the posttransplant outcomes in recipients of increased-risk organs. Read More

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http://dx.doi.org/10.1155/2016/9658904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061985PMC
September 2016
2 Reads

Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice.

J Transplant 2016 22;2016:4570842. Epub 2016 Sep 22.

Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, Logan, UT, USA.

Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d) ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. Read More

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http://dx.doi.org/10.1155/2016/4570842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055969PMC
September 2016
8 Reads

Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect.

J Transplant 2016 1;2016:9709430. Epub 2016 Sep 1.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.

There is a paucity of literature examining recipient-donor obesity matching on liver transplantation outcomes. The United Network for Organ Sharing database was queried for first-time recipients of liver transplant whose age was ≥18 between January 2003 and September 2013. Outcomes including patient and graft survival at 30 days, 1 year, and 5 years and overall, liver retransplantation, and length of stay were compared between nonobese recipients receiving a graft from nonobese donors and obese recipient-obese donor, obese recipient-nonobese donor, and nonobese recipient-obese donor pairs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023820PMC
http://dx.doi.org/10.1155/2016/9709430DOI Listing
October 2016
26 Reads

C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch.

J Transplant 2016 4;2016:2106028. Epub 2016 Sep 4.

Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, 14080 Mexico City, Mexico.

The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies (DSA) and were tested with FXM. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027038PMC
http://dx.doi.org/10.1155/2016/2106028DOI Listing
October 2016
24 Reads

For and against Organ Donation and Transplantation: Intricate Facilitators and Barriers in Organ Donation Perceived by German Nurses and Doctors.

J Transplant 2016 15;2016:3454601. Epub 2016 Aug 15.

Institute of Integrative Medicine, Faculty of Medicine, Witten/Herdecke University, Herdecke, Gerhard-Kienle-Weg 4, 58313 Herdecke, Germany.

Background. Significant facilitators and barriers to organ donation and transplantation remain in the general public and even in health professionals. Negative attitudes of HPs have been identified as the most significant barrier to actual ODT. Read More

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http://dx.doi.org/10.1155/2016/3454601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002484PMC
September 2016
14 Reads

The Kidney Transplant Evaluation Process in the Elderly: Reasons for Being Turned down and Opportunities to Improve Cost-Effectiveness in a Single Center.

J Transplant 2016 4;2016:7405930. Epub 2016 Aug 4.

Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Background. The kidney transplant evaluation process for older candidates is complex due to the presence of multiple comorbid conditions. Methods. Read More

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http://dx.doi.org/10.1155/2016/7405930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989053PMC
August 2016
33 Reads

The Utility of Routine Ultrasound Imaging after Elective Transplant Ureteric Stent Removal.

J Transplant 2016 14;2016:1231567. Epub 2016 Jul 14.

Department of Nephrology and Transplantation, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.

Background. Ureteric stent insertion during kidney transplantation reduces the incidence of major urological complications (MUCs). We evaluated whether routine poststent removal graft ultrasonography (PSRGU) was useful in detecting MUCs before they became clinically or biochemically apparent. Read More

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http://dx.doi.org/10.1155/2016/1231567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963558PMC
August 2016
7 Reads

Clinical Course and Outcomes of Late Kidney Allograft Dysfunction.

J Transplant 2016 10;2016:7401808. Epub 2016 Jul 10.

Transplant Center, Regional Hospital, Illyicha Avenue 14, Donetsk 83000, Ukraine.

Background. This study is provided to increase the efficiency of the treatment of kidney transplant recipients by predicting the development of the late allotransplant dysfunction. Methods. Read More

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http://dx.doi.org/10.1155/2016/7401808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958442PMC
August 2016
11 Reads

Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique.

J Transplant 2016 10;2016:2586761. Epub 2016 Jul 10.

Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, USA.

Background. Acceptance of dual kidney transplantation (DKT) has proven difficult, due to surgical complexity and concerns regarding long-term outcomes. We herein present a standard technique for ipsilateral DKT and compare outcomes to single-kidney transplant (SKT) recipients. Read More

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http://dx.doi.org/10.1155/2016/2586761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958440PMC
August 2016
15 Reads

Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation.

J Transplant 2016 22;2016:7187206. Epub 2016 Jun 22.

Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Coronary artery disease (CAD) is prevalent in patients with end-stage liver disease and associated with poor outcomes when undergoing orthotopic liver transplantation (OLT); however, noninvasive screening for CAD in this population is less sensitive. In an attempt to identify redundancy, we reviewed our experience among patients undergoing CAD screening as part of their OLT evaluation between May 2009 and February 2014. Demographic, clinical, and procedural characteristics were analyzed. Read More

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http://dx.doi.org/10.1155/2016/7187206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933843PMC
July 2016
17 Reads

Current Treatment Approaches to HCC with a Special Consideration to Transplantation.

J Transplant 2016 20;2016:7926264. Epub 2016 Jun 20.

Department of Hepatobiliary and Pancreatic Surgery, Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford OX3 7LE, UK.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. The mainstay of treatment of HCC has been both resectional and transplantation surgery. It is well known that, in selected, optimized patients, hepatectomy for HCC may be an option, even in patients with underlying cirrhosis. Read More

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http://dx.doi.org/10.1155/2016/7926264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931061PMC
July 2016
2 Reads

Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation.

J Transplant 2016 15;2016:1916387. Epub 2016 Jun 15.

Division of Transplantation, Department of Surgery, University of Alberta, Edmonton, AB, Canada T6G 2B7.

Background. We aimed to assess incidentally discovered hepatocellular carcinoma (iHCC) over time and to compare outcome to preoperatively diagnosed hepatocellular carcinoma (pdHCC) and nontumor liver transplants. Methods. Read More

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http://dx.doi.org/10.1155/2016/1916387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925966PMC
July 2016
11 Reads

Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience.

J Transplant 2016 10;2016:7895956. Epub 2016 Jan 10.

Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany; IFB-TX Core Facility and HTA, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany.

Background. This is a single center oncological resume overlooking four decades of experience with liver transplantation (LT) for hepatocellular carcinoma (HCC). Methods. Read More

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http://dx.doi.org/10.1155/2016/7895956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736995PMC
April 2016
15 Reads

Lung Transplantation in Patients with High Lung Allocation Scores in the US: Evidence for the Need to Evaluate Score Specific Outcomes.

J Transplant 2015 21;2015:836751. Epub 2015 Dec 21.

University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Objective. The lung allocation score (LAS) resulted in a lung transplantation (LT) selection process guided by clinical acuity. We sought to evaluate the relationship between LAS and outcomes. Read More

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http://dx.doi.org/10.1155/2015/836751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698782PMC
January 2016
19 Reads

Risk Factors Associated with Increased Morbidity in Living Liver Donation.

J Transplant 2015 15;2015:949674. Epub 2015 Dec 15.

Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Rua Barata Ribeiro 414, cj 65, 01308-000 Bela Vista, SP, Brazil; Hepatology and Liver Transplantation, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.

Living donor liver donation (LDLD) is an alternative to cadaveric liver donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This is a retrospective cohort study in 688 donors between June 1995 and February 2014 at Hospital Sírio-Libanês and A. Read More

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http://downloads.hindawi.com/journals/jtrans/2015/949674.pdf
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http://www.hindawi.com/journals/jtrans/2015/949674/
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http://dx.doi.org/10.1155/2015/949674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693020PMC
January 2016
23 Reads

Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis.

J Transplant 2015 30;2015:639628. Epub 2015 Nov 30.

1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Mikras Asias Street 75, 11527 Athens, Greece.

Background. Posttransplant recurrence of primary focal segmental glomerulosclerosis (rFSGS) in the form of massive proteinuria is not uncommon and has detrimental consequences on renal allograft survival. A putative circulating permeability factor has been implicated in the pathogenesis leading to widespread use of plasma exchange (PLEX). Read More

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http://www.hindawi.com/journals/jtrans/2015/639628/
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http://dx.doi.org/10.1155/2015/639628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677212PMC
December 2015
13 Reads

Psychosocial Status of Liver Transplant Candidates in Iran and Its Correlation with Health-Related Quality of Life and Depression and Anxiety.

J Transplant 2015 15;2015:329615. Epub 2015 Nov 15.

Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran 1419733141, Iran ; Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran 1419733141, Iran.

Objectives. The study was aimed at providing a psychosocial profile for Iranian liver transplant candidates referred to an established liver transplantation program. Material and Methods. Read More

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http://dx.doi.org/10.1155/2015/329615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662971PMC
December 2015
31 Reads

Influence of Deceased Donor and Pretransplant Recipient Parameters on Early Overall Kidney Graft-Survival in Germany.

J Transplant 2015 11;2015:307230. Epub 2015 Oct 11.

Deutsche Stiftung Organtransplantation, Region Baden-Württemberg, Kriegerstraße 6, 70192 Stuttgart, Germany.

Background. Scarcity of grafts for kidney transplantation (KTX) caused an increased consideration of deceased donors with substantial risk factors. There is no agreement on which ones are detrimental for overall graft-survival. Read More

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http://dx.doi.org/10.1155/2015/307230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619958PMC
November 2015
8 Reads

Delayed Graft Function in Kidney Transplants: Time Evolution, Role of Acute Rejection, Risk Factors, and Impact on Patient and Graft Outcome.

J Transplant 2015 10;2015:163757. Epub 2015 Sep 10.

Department of Nephrology, Dialysis and Transplantation and Department of Abdominal Surgery, CUB, Erasmus Hospital, Route de Lennik 808, 1070 Brussels, Belgium.

Background. Although numerous risk factors for delayed graft function (DGF) have been identified, the role of ischemia-reperfusion injury and acute rejection episodes (ARE) occurring during the DGF period is ill-defined and DGF impact on patient and graft outcome remains controversial. Methods. Read More

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http://www.hindawi.com/journals/jtrans/2015/163757/
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http://dx.doi.org/10.1155/2015/163757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581567PMC
October 2015
22 Reads

Alternative Living Kidney Donation Programs Boost Genetically Unrelated Donation.

J Transplant 2015 2;2015:748102. Epub 2015 Sep 2.

Department of Internal Medicine, Erasmus MC, s-Gravendijkwal 230, 3015 CE Rotterdam, Netherlands.

Donor-recipient ABO and/or HLA incompatibility used to lead to donor decline. Development of alternative transplantation programs enabled transplantation of incompatible couples. How did that influence couple characteristics? Between 2000 and 2014, 1232 living donor transplantations have been performed. Read More

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http://dx.doi.org/10.1155/2015/748102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572426PMC
September 2015
6 Reads

Factors Associated with Uncontrolled Hypertension among Renal Transplant Recipients Attending Nephrology Clinics in Nairobi, Kenya.

J Transplant 2015 14;2015:746563. Epub 2015 Jul 14.

Department of Clinical Medicine and Therapeutics, University of Nairobi (UoN), P.O. Box 60337-00200, Nairobi, Kenya ; Kenyatta National Hospital (KNH), Nairobi, Kenya.

Objective. To determine the factors associated with poor blood pressure control among renal transplant recipients in a resource-limited setting. Methods. Read More

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http://dx.doi.org/10.1155/2015/746563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518186PMC
August 2015
7 Reads

Boceprevir-Based Triple Antiviral Therapy for Chronic Hepatitis C Virus Infection in Kidney-Transplant Candidates.

J Transplant 2015 16;2015:159795. Epub 2015 Jul 16.

Department of Nephrology and Organ Transplantation, CHU Rangueil, 31059 Toulouse, France ; INSERM U1043, IFR-BMT, CHU Purpan, 31059 Toulouse, France ; Université Paul Sabatier, 31000 Toulouse, France.

Background. There are few data on the combination of (pegylated-) interferon- (Peg-IFN-) α, ribavirin, and first-generation direct-acting antiviral agents (DAAs). Our aim was to describe the efficacy and safety of Peg-IFN-α, ribavirin, and boceprevir in hemodialysis patients. Read More

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http://dx.doi.org/10.1155/2015/159795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519545PMC
August 2015
21 Reads