3,159 results match your criteria Journal of Translational Medicine [Journal]


Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China.

J Transl Med 2019 Feb 15;17(1):46. Epub 2019 Feb 15.

Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301, Yanchang Road, Shanghai, China.

Background: Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in China and find out the potential risk factors including air pollutant.

Methods: 23,922 eligible outpatients were recruited from ophthalmic clinics of 32 cities in China in 2013 by registration orders. Read More

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http://dx.doi.org/10.1186/s12967-019-1794-6DOI Listing
February 2019
3.930 Impact Factor

Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke.

J Transl Med 2019 Feb 13;17(1):45. Epub 2019 Feb 13.

Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

Background: Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, epidemiological data may understate its actual prevalence. Meanwhile, AF is considered to be a major cause of ischemic strokes due to irregular heart-rhythm, coexisting chronic vascular inflammation, and renal insufficiency, and blood stasis. We studied co-expressed genes to understand relationships between atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF-related stroke. Read More

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http://dx.doi.org/10.1186/s12967-019-1790-xDOI Listing
February 2019

Data-driven clinical decision processes: it's time.

J Transl Med 2019 Feb 12;17(1):44. Epub 2019 Feb 12.

Center for Computational Science, University of Miami, Miami, FL, USA.

Changes and transformations enabled by Big Data have direct effects on Translational Medicine. At one end, superior precision is expected from a more data-intensive and individualized medicine, thus accelerating scientific discovery and innovation (in diagnosis, therapy, disease management etc.). Read More

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http://dx.doi.org/10.1186/s12967-019-1795-5DOI Listing
February 2019

The phylogeny of 48 alleles, experimentally verified at 21 kb, and its application to clinical allele detection.

J Transl Med 2019 Feb 11;17(1):43. Epub 2019 Feb 11.

Laboratory Services Section, Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA.

Background: Sequence information generated from next generation sequencing is often computationally phased using haplotype-phasing algorithms. Utilizing experimentally derived allele or haplotype information improves this prediction, as routinely used in HLA typing. We recently established a large dataset of long ERMAP alleles, which code for protein variants in the Scianna blood group system. Read More

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http://dx.doi.org/10.1186/s12967-019-1791-9DOI Listing
February 2019

How stakeholder engagement influenced a randomized comparative effectiveness trial testing two Diabetes Prevention Program interventions in a Marshallese Pacific Islander Community.

J Transl Med 2019 Feb 11;17(1):42. Epub 2019 Feb 11.

University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR, 72205, USA.

Background: Marshallese face significant health disparities, with particularly high rates of type 2 diabetes. Engaging stakeholders in the research process is essential to reduce health inequities.

Methods: A community- and patient-engaged research approach was used to involve community Marshallese stakeholders in a randomized comparative effectiveness trial testing two Diabetes Prevention Program interventions. Read More

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http://dx.doi.org/10.1186/s12967-019-1793-7DOI Listing
February 2019

New risk score for predicting progression of membranous nephropathy.

J Transl Med 2019 Feb 8;17(1):41. Epub 2019 Feb 8.

Department of Nephrology, Institute of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.

Background: Patients with Idiopathic membranous nephropathy (IMN) have various outcomes. The aim of this study is to construct a tool for clinicians to precisely predict outcome of IMN.

Methods: IMN patients diagnosed by renal biopsy from Shanghai Ruijin Hospital from 2009. Read More

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http://dx.doi.org/10.1186/s12967-019-1792-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368730PMC
February 2019
1 Read

Peripheral T cell receptor beta immune repertoire is promptly reconstituted after acute myocardial infarction.

J Transl Med 2019 Feb 6;17(1):40. Epub 2019 Feb 6.

College of Basic Medicine, Qingdao University, Qingdao, Shandong, China.

Background: Acute myocardial infarction (AMI) is characterized by an inflammatory process in which T cell plays a key role. However, the profile of immune microenvironment in AMI is still uncertain. High-throughput sequencing of T cell receptor (TCR) provides deep insight into monitoring the immune microenvironment. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1788-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366076PMC
February 2019
5 Reads

DRAP: a toolbox for drug response analysis and visualization tailored for preclinical drug testing on patient-derived xenograft models.

J Transl Med 2019 Jan 29;17(1):39. Epub 2019 Jan 29.

Shanghai Center for Bioinformation Technology, 1278 Keyuan Road, Shanghai, 201203, People's Republic of China.

Background: One of the key reasons for the high failure rate of new agents and low therapeutic benefit of approved treatments is the lack of preclinical models that mirror the biology of human tumors. At present, the optimal cancer model for drug response study to date is patient-derived xenograft (PDX) models. PDX recaptures both inter- and intra-tumor heterogeneity inherent in human cancer, which represent a valuable platform for preclinical drug testing and personalized medicine applications. Read More

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http://dx.doi.org/10.1186/s12967-019-1785-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350365PMC
January 2019

Serum protein signature of coronary artery disease in type 2 diabetes mellitus.

J Transl Med 2019 Jan 24;17(1):17. Epub 2019 Jan 24.

Drug Discovery Research Center, Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, 121001, India.

Background: Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The purpose of the present study was to discriminate the Indian CAD patients with or without T2DM by using multiple pathophysiological biomarkers.

Methods: Using sensitive multiplex protein assays, we assessed 46 protein markers including cytokines/chemokines, metabolic hormones, adipokines and apolipoproteins for evaluating different pathophysiological conditions of control, T2DM, CAD and T2DM with CAD patients (T2DM_CAD). Read More

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http://dx.doi.org/10.1186/s12967-018-1755-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345069PMC
January 2019
4 Reads

Mathematical models of amino acid panel for assisting diagnosis of children acute leukemia.

J Transl Med 2019 Jan 23;17(1):38. Epub 2019 Jan 23.

Clinical Center for Molecular Medicine, Children's Hospital of Chongqing Medical University, 136 Zhongshan 2 Rd, Chongqing, 400014, China.

Background: The altered concentrations of amino acids were found in the bone marrow or blood of leukemia patients. Metabolomics technology combining mathematical model of biomarkers could be used for assisting the diagnosis of pediatric acute leukemia (AL).

Methods: The concentrations of 17 amino acids was measured by targeted liquid chromatograph-tandem mass spectrometry in periphery blood collected using dried blood spots. Read More

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http://dx.doi.org/10.1186/s12967-019-1783-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343345PMC
January 2019

LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production.

J Transl Med 2019 Jan 22;17(1):37. Epub 2019 Jan 22.

Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the presence of pathogenic autoantibodies associated with polyclonal B cell hyperreactivity. Previous study reported that autophagy-related gene Leucine-rich repeat kinase 2 (LRRK2) was likely a susceptible gene for SLE. However, the pathogenic function of LRRK2 in SLE is undefined. Read More

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http://dx.doi.org/10.1186/s12967-019-1786-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343316PMC
January 2019
3 Reads
3.930 Impact Factor

Macrophages are necessary for skin regeneration during tissue expansion.

J Transl Med 2019 Jan 21;17(1):36. Epub 2019 Jan 21.

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, 127 Chanle West Road, Xi'an, 710032, Shaanxi Province, China.

Background: Tissue expansion is a procedure that promotes skin regeneration by mechanical stretch. During the stress and relaxation cycle, the skin undergoes a repeated microtrauma which triggers an immune response leading to the recruitment of macrophages to repair the damaged tissue. Macrophages have been found to be necessary for tissue repair and wound healing, but their effects on skin regeneration during mechanical stretch remain unclear. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1780-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341552PMC
January 2019
6 Reads

An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers.

J Transl Med 2019 Jan 21;17(1):35. Epub 2019 Jan 21.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, 100050, China.

Background: Despite that most HIV-infected individuals experience progressive CD4+ T cell loss and develop AIDS, a minority of HIV-infected individuals remain asymptomatic and maintain high level CD4+ T cell counts several years after seroconversion. Efforts have been made to understand the determinants of the nonprogressive status, exemplified by the clinical course of elite controllers (ECs) who maintain an undetectable viremia and viremic nonprogressors (VNPs) who have a normal CD4+ count in spite of circulating viral load. However, the intrinsic mechanism underlying nonprogression remained elusive. Read More

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http://dx.doi.org/10.1186/s12967-019-1777-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341564PMC
January 2019

Climate, human behaviour or environment: individual-based modelling of Campylobacter seasonality and strategies to reduce disease burden.

J Transl Med 2019 Jan 21;17(1):34. Epub 2019 Jan 21.

Institute of Infection and Global Health, Liverpool University, Liverpool, L69 7BE, UK.

Background: With over 800 million cases globally, campylobacteriosis is a major cause of food borne disease. In temperate climates incidence is highly seasonal but the underlying mechanisms are poorly understood, making human disease control difficult. We hypothesised that observed disease patterns reflect complex interactions between weather, patterns of human risk behaviour, immune status and level of food contamination. Read More

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http://dx.doi.org/10.1186/s12967-019-1781-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341592PMC
January 2019
2 Reads

Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis.

J Transl Med 2019 Jan 21;17(1):33. Epub 2019 Jan 21.

US Army Institute of Surgical Research, Extremity Trauma and Regenerative Medicine, 3698 Chambers Pass BLDG 3611, Ft. Sam Houston, San Antonio, TX, 78234, USA.

Ischemia-reperfusion injury is caused by a period of ischemia followed by massive blood flow into a tissue that had experienced restricted blood flow. The severity of the injury is dependent on the time the tissue was restricted from blood flow, becoming more severe after longer ischemia times. This can lead to many complications such as tissue necrosis, cellular apoptosis, inflammation, metabolic and mitochondrial dysfunction, and even organ failure. Read More

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http://dx.doi.org/10.1186/s12967-018-1753-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340183PMC
January 2019

Three-dimensional nanostructured substrates enable dynamic detection of ALK-rearrangement in circulating tumor cells from treatment-naive patients with stage III/IV lung adenocarcinoma.

J Transl Med 2019 Jan 18;17(1):32. Epub 2019 Jan 18.

Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, People's Republic of China.

Background: Circulating tumor cells (CTC) shows great prospect to realize precision medicine in cancer patients.

Methods: We developed the NanoVelcro Chip integrating three functional mechanisms. NanoVelcro CTC capture efficiency was tested in stage III or IV lung adenocarcinoma. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1779-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339314PMC
January 2019
3 Reads

Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance.

J Transl Med 2019 Jan 18;17(1):31. Epub 2019 Jan 18.

Department of Neurology and Neurological Sciences, Stanford University, 1201 Welch Road, MSLS P250, Stanford, CA, 94305, USA.

Botticelli et al. proposed the activity of indoleamine-2,3-dioxygenase 1 (IDO) as a potential mechanism and predictive marker for primary resistance against anti-PD-1 treatment in the context of non-small cell lung cancer. However, there are a few points for the authors to address in order to strengthen their claims. Read More

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http://dx.doi.org/10.1186/s12967-019-1784-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339344PMC
January 2019
1 Read

Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer.

J Transl Med 2019 Jan 18;17(1):30. Epub 2019 Jan 18.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Background: Systemic inflammation and immune dysfunction have been proved to be associated with cancer progression and metastasis in various malignancies. The aim of this retrospective study was to evaluate the prognostic significance of pre-treatment systemic immune-inflammation index (SII) in patients with advanced pancreatic cancer.

Methods: In total, 419 patients diagnosed with advanced pancreatic cancer, between January 2011 and December 2015, were retrospectively enrolled. Read More

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http://dx.doi.org/10.1186/s12967-019-1782-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339361PMC
January 2019

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model.

J Transl Med 2019 Jan 17;17(1):29. Epub 2019 Jan 17.

Translational and Clinical Research Program, University of Hawaii Cancer Center, 701 Ilalo Street Suite 353, Honolulu, HI, 96813, USA.

Background: We set out to determine if the administration of subcutaneous (SQ) ALT-803 was non-inferior to standard intravesical BCG treatment in a carcinogen induced mouse (C57BL/6J) bladder cancer model.

Methods: Using this well-established carcinogen induced mouse model, we studied the effects of various dosing schemas of ALT-803 (SQ alone, SQ with intravesical BCG, intravesical alone, intravesical with intravesical BCG) compared to intravesical BCG alone (positive control) and PBS (negative control). The non-inferiority margin for the difference in bladder weight, as a surrogate for tumor mass, was defined as 7%. Read More

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http://dx.doi.org/10.1186/s12967-019-1778-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337786PMC
January 2019

The emerging role of WISP proteins in tumorigenesis and cancer therapy.

J Transl Med 2019 Jan 16;17(1):28. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, China.

Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. Read More

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http://dx.doi.org/10.1186/s12967-019-1769-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335850PMC
January 2019
1 Read

Clinical and genetic risk factors for Fulvestrant treatment in post-menopause ER-positive advanced breast cancer patients.

J Transl Med 2019 Jan 15;17(1):27. Epub 2019 Jan 15.

The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University / Hunan Cancer Hospital, Changsha, 410013, China.

Background: Among breast cancer (BC) patients, near 40% are post-menopause, and 70%-80% are hormone receptor (HR)-positive. About 30%-40% BC patients who are diagnosed as invasive carcinoma HR-positive BC would eventually develop metastatic breast cancers. In 2016, FALCON trial proves Fulvestrant as an effective first-line endocrine therapy for post-menopause HR-positive advanced BC (ABC) patients. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1734-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334389PMC
January 2019
6 Reads

Hypercholesterolemia-induced increase in plasma oxidized LDL abrogated pro angiogenic response in kidney grafts.

J Transl Med 2019 Jan 14;17(1):26. Epub 2019 Jan 14.

INSERM U1082 IRTOMIT, 2 rue de la Milétrie, CS90577, 86000, Poitiers, France.

Background: Renal transplantation is increasingly associated with the presence of comorbidity factors such as dyslipidemia which could influence the graft outcome. We hypothesized that hypercholesterolemia could affect vascular repair processes and promote post-transplant renal vascular remodeling through the over-expression of the anti-angiogenic thrombospondin-1 interacting with vascular endothelial growth factor-A levels.

Methods: We tested this hypothesis in vitro, in vivo and in a human cohort using (1) endothelial cells; (2) kidney auto-transplanted pig subjected (n = 5) or not (n = 6) to a diet enriched in cholesterol and (3) a renal transplanted patient cohort (16 patients). Read More

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http://dx.doi.org/10.1186/s12967-018-1764-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332834PMC
January 2019

Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity.

J Transl Med 2019 Jan 14;17(1):25. Epub 2019 Jan 14.

Department of Molecular Genetics, Medical Scientific Research Center, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.

Background: The present study attempted to identify potential key genes and miRNAs of dyslipidemia in obese, and to investigate the possible mechanisms associated with them.

Methods: The microarray data of GSE66676 were downloaded, including 67 obese samples from the Gene Expression Omnibus (GEO) database. The weighted gene co-expression network (WGCNA) analysis was performed using WGCNA package and grey60 module was considered as the highest correlation. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1776-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332685PMC
January 2019
4 Reads

Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer.

J Transl Med 2019 Jan 11;17(1):19. Epub 2019 Jan 11.

Department of Radiology, University of Mississippi Medical Center, Jackson, MS, 39126, USA.

Background: Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachment, thus murine cells are generally non-permissive for human adenoviral infection and replication, which limits translational studies.

Methods: We have developed a gene transfer method that uses a combination of lipid-encapsulated perfluorocarbon microbubbles and ultrasound to protect and deliver hAds to a target tissue, bypassing the requirement of specific receptors. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1771-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329087PMC
January 2019
4 Reads

Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture.

J Transl Med 2019 Jan 11;17(1):23. Epub 2019 Jan 11.

Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), 10 Center Drive-MSC-1184, Building 10, Room 3C720, Bethesda, MD, 20892-1184, USA.

Background: Bone marrow stromal cells (BMSCs) are a heterogeneous population that participates in wound healing, immune modulation and tissue regeneration. Next generation sequencing was used to analyze transcripts from single BMSCs in order to better characterize BMSC subpopulations.

Methods: Cryopreserved passage 2 BMSCs from one healthy subject were cultured through passage 10. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1766-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330466PMC
January 2019
4 Reads

MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.

J Transl Med 2019 Jan 11;17(1):22. Epub 2019 Jan 11.

Department of Hand, Plastic and Reconstructive Surgery, University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann Str. 13, 67071, Ludwigshafen, Germany.

Background: Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly investigated. Arteriovenous (AV) shunts are an established model for induction of neoangiogenesis in vivo and can serve as a tool for analysis of hemodynamic effects on miRNA and gene expression profiles over time. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1767-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330440PMC
January 2019
4 Reads

Regeneration of a neoartery through a completely autologous acellular conduit in a minipig model: a pilot study.

J Transl Med 2019 Jan 11;17(1):24. Epub 2019 Jan 11.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Vascular grafts are widely used as a treatment in coronary artery bypass surgery, hemodialysis, peripheral arterial bypass and congenital heart disease. Various types of synthetic and natural materials were experimented to produce tissue engineering vascular grafts. In this study, we investigated in vivo tissue engineering technology in miniature pigs to prepare decellularized autologous extracellular matrix-based grafts that could be used as vascular grafts for small-diameter vascular bypass surgery. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1763-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330492PMC
January 2019
4 Reads
3.930 Impact Factor

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α.

J Transl Med 2019 Jan 11;17(1):20. Epub 2019 Jan 11.

Department of Basic Medical Sciences Neurosciences and Sense Organs, University of Bari, Bari, Italy.

Background: Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay between the stress response and the gene expression programs leading to metastatic spread has been reported.

Methods: We evaluated levels and localization of eIF2α/peIF2α in V600BRAF and wtBRAF metastatic melanoma cell lines by means of western blot and confocal microscopy analyses. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1772-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329103PMC
January 2019
5 Reads
3.930 Impact Factor

Characteristics of T cell receptor repertoires of patients with acute myocardial infarction through high-throughput sequencing.

J Transl Med 2019 Jan 11;17(1):21. Epub 2019 Jan 11.

Center for Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, 514031, People's Republic of China.

Background: T cells are key regulators of immunity and one of the cells recruited in atherosclerosis and participated in various stages of the development of atherosclerosis. Characterizing T-cell receptor (TCR) repertoires is a priority of great scientific interest and potential clinical utility for the early diagnosis, risk stratification and prognostic evaluation of acute myocardial infarction (AMI).

Methods: The TCR repertoires in 21 subjects including 7 patients with non-ST-segment elevation myocardial infarction (NSTEMI), 6 patients with ST-segment elevation myocardial infarction (STEMI) and 8 subjects with normal coronary artery (NCA) as control were characterized by using high-throughput sequencing. Read More

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http://dx.doi.org/10.1186/s12967-019-1768-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330436PMC
January 2019
1 Read

Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis.

J Transl Med 2019 Jan 10;17(1):18. Epub 2019 Jan 10.

Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, 137-070, South Korea.

Background: Spondyloarthritis (SpA) is chronic inflammatory arthritis, and interleukin (IL)-17 is crucial in SpA pathogenesis. Type 17 helper T (Th17) cells are one of major IL-17-secreting cells. Signal transducer and activator of transcription (STAT)-3 signaling induces Th17 differentiation. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1774-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329133PMC
January 2019
3 Reads

Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes.

J Transl Med 2019 Jan 9;17(1):15. Epub 2019 Jan 9.

Servicio de Pediatría, Consorcio Hospital General Universitario de Valencia, 46014, Valencia, Spain.

Background: Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes that occur during this period have not been sufficiently characterized in longitudinal studies.

Methods: To this end, we studied the DNA methylation status of more than 750,000 CpG sites using Illumina MethylationEPIC arrays on 33 paired blood samples from 11 subjects at birth and at 5 and 10 years of age, then characterized the chromatin context associated with these loci by integrating our data with histone, chromatin-state and enhancer-element external datasets, and, finally, validated our results through bisulfite pyrosequencing in two independent longitudinal cohorts of 18 additional subjects. Read More

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http://dx.doi.org/10.1186/s12967-018-1751-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327427PMC
January 2019

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers.

J Transl Med 2019 Jan 9;17(1):14. Epub 2019 Jan 9.

Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK.

Background: Despite much progress in cancer research, its incidence and mortality continue to rise. A robust biomarker that would predict tumor behavior is highly desirable and could improve patient treatment and prognosis.

Methods: In a retrospective bioinformatics analysis involving patients with liver cancer (n = 839), we developed a prognostic signature consisting of 45 genes associated with tumor-infiltrating lymphocytes and cellular responses to hypoxia. Read More

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http://dx.doi.org/10.1186/s12967-019-1775-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327401PMC
January 2019
1 Read

Clinical verification of the relationship between smoking and the immune microenvironment of breast cancer.

J Transl Med 2019 Jan 7;17(1):13. Epub 2019 Jan 7.

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: The immune tumor microenvironment (iTME) is thought to affect the response to chemotherapy, and tumor-infiltrating lymphocytes (TILs) are often used as an indicator to evaluate the iTME. Smoking is involved in carcinogenesis, the relationship between smoking and the iTME of lung cancer has been reported. We hypothesized that smoking would affect the iTME of breast cancer and aimed to examine this relationship based on the amount of pre-diagnosis smoking and the subsequent effects on treatment response and prognosis. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1773-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323676PMC
January 2019
4 Reads

In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells.

J Transl Med 2019 Jan 7;17(1):12. Epub 2019 Jan 7.

Renal Unit, Department of Medicine, University-Hospital of Verona, Piazzale A. Stefani 1, 37126, Verona, VR, Italy.

Background: The epithelial to mesenchymal transition (EMT) is a multi-factorial biological mechanism involved in renal and hepatic fibrosis and the IL-1 beta has been assumed as a mediator of this process although data are not exhaustive. Therefore, the aim of our study was to evaluate the role of this cytokine in the EMT of renal proximal tubular epithelial cells (HK-2) and stellate cells (LX-2) and the protective/anti-fibrotic effect of its inhibition by Canakinumab (a specific human monoclonal antibody targeted against IL-1beta).

Methods: Both cell types were treated with IL-1 beta (10 ng/ml) for 6 and 24 h with and without Canakinumab (5 μg/ml). Read More

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http://dx.doi.org/10.1186/s12967-019-1770-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323803PMC
January 2019
1 Read

Establishment of clinical diagnosis model of Graves' disease and Hashimoto's thyroiditis.

J Transl Med 2019 Jan 7;17(1):11. Epub 2019 Jan 7.

Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.

Background: A clinical diagnosis model include thyroid functions, thyroid antibodies and radioactive iodine uptake (RAIU) of patients with hyperthyroidism were established and as new evaluation indicators for the differentiation of the Graves' disease (GD) and Hashimoto's thyroiditis (HT).

Methods: Clinical data of patients with newly diagnosed hyperthyroidism including gender, age, thyroid function, thyroid antibodies (FT3, FT4, TSH, TPOAb, TGAb, TRAb), RAIU (2 h, 6 h, 24 h) were collected. A stepwise regression analysis was performed to establish a model based on these variables. Read More

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http://dx.doi.org/10.1186/s12967-018-1765-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322254PMC
January 2019
5 Reads

Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation.

J Transl Med 2019 Jan 5;17(1):10. Epub 2019 Jan 5.

The Centre of Research and Formation High Technologies "Johannes Paulus II", Catholic University of Campobasso, Campobasso, Italy.

Background: This study examined the quality of bone marrow aspirates extracted using a novel, FDA cleared method to optimally target cells from the inner cortical iliac bone surface without the need for centrifugation. This method employs small draws from a single puncture that promote only lateral flow from multiple sites (SSLM method). The study utilized the Marrow Cellutions bone marrow aspiration system (MC system) which is based on the SSLM method and compared the MC system directly to bone marrow concentrates (BMAC) generated by centrifugation of aspirates harvested with a standard aspiration needle. Read More

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http://dx.doi.org/10.1186/s12967-018-1750-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321705PMC
January 2019
1 Read

Identification of potential miRNA-mRNA regulatory network contributing to pathogenesis of HBV-related HCC.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

Program of Innovative Cancer Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, College of Medicine, Key Laboratory of Organ Transplantation, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, China.

Background: Hepatitis B virus (HBV) is one of the major risk factors of hepatocellular carcinoma (HCC). Increasing evidence indicates that microRNA (miRNA)-mRNA axis is involved in HCC. However, a comprehensive miRNA-mRNA regulatory network in HBV-related HCC is still absent. Read More

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http://dx.doi.org/10.1186/s12967-018-1761-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317219PMC
January 2019
1 Read
3.930 Impact Factor

An innovative total temporomandibular joint prosthesis with customized design and 3D printing additive fabrication: a prospective clinical study.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, No. 639 Zhi Zao Ju Rd, Shanghai, 200011, China.

Background: Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of joint reconstruction. However, there is still an urgent need to design a new TMJ prosthesis because of no commercially available TMJ prosthesis appropriate for the clinical application on the Chinese population. This study was introduced to prospectively confirm the safety and effectiveness of a new TMJ prosthesis with customized design and 3D printing additive fabrication in clinical application. Read More

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http://dx.doi.org/10.1186/s12967-018-1759-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317245PMC
January 2019

Interferon-alpha 2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

Integrated Care Department of Public Health and Drug-Use, Section of Medical Pharmacology and Toxicology, "Federico II" University, Naples, Italy.

Background: Intramuscular triglycerides (IMTGs) represent an important energy supply and a dynamic fat-storage depot that can expand during periods of elevated lipid availability and a fatty acid source. Ultrasonography (US) of human skeletal muscles is a practical and reproducible method to assess both IMTG presence and entity. Although a crosstalk between cytokines in skeletal muscle and adipose tissue has been suggested in obesity, condition leading to hepatic steatosis (HS) or better defined as nonalcoholic fatty liver disease and cancer, there are still questions to be answered about the role of interferons (IFNs), alpha as well as gamma, and IMTG in obesity. Read More

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http://dx.doi.org/10.1186/s12967-018-1754-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317208PMC
January 2019

Exosomes of pasteurized milk: potential pathogens of Western diseases.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, University of Regensburg, Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

Milk consumption is a hallmark of western diet. According to common believes, milk consumption has beneficial effects for human health. Pasteurization of cow's milk protects thermolabile vitamins and other organic compounds including bioactive and bioavailable exosomes and extracellular vesicles in the range of 40-120 nm, which are pivotal mediators of cell communication via systemic transfer of specific micro-ribonucleic acids, mRNAs and regulatory proteins such as transforming growth factor-β. Read More

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http://dx.doi.org/10.1186/s12967-018-1760-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317263PMC
January 2019
3 Reads

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

Center of Internal Medicine II, Brandenburg Medical School, University Hospital Brandenburg, Hochstrasse 29, 14770, Brandenburg, Germany.

Background: Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment. We developed a powerful and rapid whole blood-based cytokine release assay assessing cellular immune responses to HBV antigens. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1752-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317231PMC
January 2019
5 Reads

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Doha, Qatar.

Background: The triple negative breast cancer (TNBC) paradox marks a major challenge in the treatment-decision making process. TNBC patients generally respond better to neoadjuvant chemotherapy compared to other breast cancer patients; however, they have a substantial higher risk of disease recurrence. We evaluated the expression of the tumor-associated antigen PReferentially Antigen expressed in MElanoma (PRAME) as a prognostic biomarker in breast cancer and explored its role in cell migration and invasion, key hallmarks of progressive and metastatic disease. Read More

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http://dx.doi.org/10.1186/s12967-018-1757-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317205PMC
January 2019
2 Reads

Identification of a serum-based miRNA signature for response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Neoadjuvant chemotherapy (NAC) has become the standard of care for resectable esophageal squamous cell carcinoma (ESCC) which is one of the most lethal cancers, to improve resectability and prognosis. On this basis, to provide individually optimized therapy for ESCC, a minimally-invasive biomarker for response to NAC is strongly desired. This study aimed to identify the miRNA signature in serum specimens taken from ESCC patients undergoing NAC through genome-wide microarray technology. Read More

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http://dx.doi.org/10.1186/s12967-018-1762-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317218PMC
January 2019
1 Read

Prediction of postoperative complications of pediatric cataract patients using data mining.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

School of Computer Science and Technology, Xidian University, No.2 South Taibai Rd, Xi'an, 710071, China.

Background: The common treatment for pediatric cataracts is to replace the cloudy lens with an artificial one. However, patients may suffer complications (severe lens proliferation into the visual axis and abnormal high intraocular pressure; SLPVA and AHIP) within 1 year after surgery and factors causing these complications are unknown.

Methods: Apriori algorithm is employed to find association rules related to complications. Read More

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http://dx.doi.org/10.1186/s12967-018-1758-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317183PMC
January 2019
1 Read

Microbiome-metabolome reveals the contribution of gut-kidney axis on kidney disease.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

School of Pharmacy, Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, 710069, Shaanxi, China.

Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and efforts in metagenomic and metabolomic analyses have led to a dramatical growth in our understanding of microbiome, but still, the mechanisms underlying gut microbiome-host interactions in healthy or diseased state remain elusive and their elucidation is in infancy. Disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation. Read More

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http://dx.doi.org/10.1186/s12967-018-1756-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317198PMC
January 2019
6 Reads
3.930 Impact Factor

Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms.

J Transl Med 2018 Dec 28;16(1):373. Epub 2018 Dec 28.

Canon Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, 875 Ellicott Street, Buffalo, NY, 14214, USA.

Background: Intracranial aneurysms (IAs) are dangerous because of their potential to rupture and cause deadly subarachnoid hemorrhages. Previously, we found significant RNA expression differences in circulating neutrophils between patients with unruptured IAs and aneurysm-free controls. Searching for circulating biomarkers for unruptured IAs, we tested the feasibility of developing classification algorithms that use neutrophil RNA expression levels from blood samples to predict the presence of an IA. Read More

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http://dx.doi.org/10.1186/s12967-018-1749-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310942PMC
December 2018
3 Reads

FGFR1 expression defines clinically distinct subtypes in pancreatic cancer.

J Transl Med 2018 Dec 28;16(1):374. Epub 2018 Dec 28.

Division of Oncology, Department of Internal Medicine, Gachon University Gil Hospital, Gachon University Gil Medical Center, Incheon, Republic of Korea.

Background: The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expression in pancreatic cancer.

Methods: First, we investigated the relationship between FGFR pathway gene expression and clinicopathological data in three pancreatic cancer cohorts containing 313 cases. Read More

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http://dx.doi.org/10.1186/s12967-018-1743-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311038PMC
December 2018
4 Reads

Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma.

J Transl Med 2018 Dec 27;16(1):372. Epub 2018 Dec 27.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Background: Lung adenocarcinoma (LUAD), largely remains a primary cause of cancer-related death worldwide. The molecular mechanisms in LUAD metastasis have not been completely uncovered.

Methods: In this study, we identified differentially expressed genes (DEGs), miRNAs (DEMs) and lncRNAs (DELs) underlying metastasis of LUAD from The Cancer Genome Atlas database. Read More

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http://dx.doi.org/10.1186/s12967-018-1732-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307237PMC
December 2018

Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials.

J Transl Med 2018 Dec 24;16(1):371. Epub 2018 Dec 24.

Department of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Turin, Italy.

Background: This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, blood pressure and other cardiometabolic risk factors.

Methods: Randomized controlled trials were systematically searched from MEDLINE, Cochrane Library, TRIP databases, EMBASE and CINAHL until May 2018. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1748-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304782PMC
December 2018
4 Reads
3.930 Impact Factor

NovelmiRNA-25 inhibits AMPD2 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and represents a promising novel biomarker.

J Transl Med 2018 Dec 22;16(1):370. Epub 2018 Dec 22.

Department of Nephrology, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325035, China.

Background: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with various clinical manifestations. MicroRNAs (miRNAs) and immunometabolism are recognized as key elements in SLE pathogenesis; however, the relationship between miRNAs in peripheral blood mononuclear cells (PBMCs) and metabolism in SLE remains unclear.

Methods: We detected PBMC miRNA and mRNA profiles from 3 pooled SLE patients and 3 healthy controls (HCs) using next-generation sequencing, predicted miRNA targets in dysregulated mRNAs, predicted functions and interactions of differentially expressed genes using bioinformatics analysis, validated candidate miRNAs using qRT-PCR, and investigated the association between the expression of candidate miRNAs and SLE clinical characteristics. Read More

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http://dx.doi.org/10.1186/s12967-018-1739-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303892PMC
December 2018
2 Reads