1,633 results match your criteria Journal of Trace Elements in Medicine and Biology[Journal]


Increasing selenium supply for heat-stressed or actively cooled sows improves piglet preweaning survival, colostrum and milk composition, as well as maternal selenium, antioxidant status and immunoglobulin transfer.

J Trace Elem Med Biol 2019 Mar 29;52:89-99. Epub 2018 Nov 29.

Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:

This study aimed to evaluate the effects of increasing selenium (Se) supply for heat-stressed or actively cooled sows on sow productivity, colostrum and milk composition, as well as the selenium and antioxidant status and immunoglobulin levels of sows and nursing piglets. The study was a 2 × 2 factorial design, where the first factor was farrowing environment [heat stress vs. actively cooling, temperature: 29. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183044
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http://dx.doi.org/10.1016/j.jtemb.2018.11.010DOI Listing
March 2019
2 Reads

Association between serum selenium level and the prevalence of diabetes mellitus in U.S. population.

J Trace Elem Med Biol 2019 Mar 10;52:83-88. Epub 2018 Dec 10.

Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea. Electronic address:

Objective: Selenium seems to be a risk factor for diabetes mellitus (DM) in recent studies, opposite to the previous expectation that it may contribute to prevent DM. The authors aimed to ascertain the relationship between selenium and DM.

Methods: Data were collected from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.005DOI Listing
March 2019
2.491 Impact Factor

Cadmium-induced hepatocellular injury: Modulatory effects of γ-glutamyl cysteine on the biomarkers of inflammation, DNA damage, and apoptotic cell death.

J Trace Elem Med Biol 2019 Mar 7;52:74-82. Epub 2018 Dec 7.

Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Taif 21974, Saudi Arabia.

Cadmium is an extremely toxic pollutant that reaches human body through intake of the industrially polluted food and water as well as through cigarette smoking and exposure to polluted air. Cadmium accumulates in different body organs especially the liver. It induces tissue injury largely through inflammation and oxidative stress-based mechanisms. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.003DOI Listing

Predicting iron absorption from an effervescent iron supplement in obese patients before and after Roux-en-Y gastric bypass: a preliminary study.

J Trace Elem Med Biol 2019 Mar 7;52:68-73. Epub 2018 Dec 7.

KU Leuven, Clinical and Experimental Endocrinology, and University Hospitals Leuven/KU Leuven, Campus Gasthuisberg, Leuven, Belgium. Electronic address:

Background & Aims: Oral iron absorption is hampered in obese and bariatric patients, especially after Roux-en-Y gastric bypass (RYGB). As a result, iron deficiency, which is common in both patient groups, can be difficult to treat by oral supplements, often necessitating a switch to parenteral administration. The aim of this study was to find possible predictors of the extent of absorption of an effervescent iron gluconate oral supplement, which enables to pre-emptively identify those patients in which oral supplementation is likely to fail. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.002DOI Listing
March 2019
2 Reads

Monitoring of salt iodisation programme in Iran; Health outcomes, shortages and perspective.

J Trace Elem Med Biol 2019 Mar 10;52:6-11. Epub 2018 Nov 10.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Centre for Water Quality Research (CWQI), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Iodine deficiency disorders include a wide range of metabolic and nonmetabolic disorders including goiter. To control IDDs, the World Health Organization and responsible agencies in countries established daily iodine uptake. Almost all the countries in the world provide the required iodine through salt iodisation. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.004DOI Listing
March 2019
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Suppression of proliferation and activation of cell death by sodium selenite involves mitochondria and lysosomes in chemoresistant bladder cancer cells.

J Trace Elem Med Biol 2019 Mar 27;52:58-67. Epub 2018 Nov 27.

Department of Medical Biology and Genetics Charles University, Faculty of Medicine in Hradec Králové, Zborovská 2089, 500 03 Hradec Králové, Czech Republic. Electronic address:

The specific effects of sodium selenite (selenite) on a chemoresistant human bladder cancer cell line RT-112/D21 were investigated during 72 h. Selenite at low concentration of 2.5 μmol (otherwise tolerated in normal urothelial cells UROtsa) suppressed growth and proliferation of the tested cancer cells via induced oxidative stress. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.009DOI Listing

Variation in trace element content between liver lobes in cattle. How important is the sampling site?

J Trace Elem Med Biol 2019 Mar 20;52:53-57. Epub 2018 Nov 20.

Department of Animal Pathology, Faculty of Veterinary Medicine, Universidade de Santiago de Compostela, 27002 Lugo, Spain.

The aim of the present study was to establish the pattern of lobular distribution of trace elements in the liver of cattle. The objective was to determine which part of the liver would provide accurate estimation of the trace element content of the whole organ. Liver samples were obtained from 10 Holstein-Friesian (HF), 10 Galician Blond (GB) and 10 GBxHF crosses (all aged 10 months) at slaughter. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.008DOI Listing
March 2019
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Ultraclean paired sampling for metal analysis in neurodegenerative disorders.

Authors:
Per M Roos

J Trace Elem Med Biol 2019 Mar 15;52:48-52. Epub 2018 Nov 15.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Physiology, Capio St.Göran Hospital, Stockholm, Sweden. Electronic address:

The causes of neurodegenerative disorders are largely unknown. Environmental factors seem to contribute to neurodegeneration in genetically susceptible individuals. Increasing evidence point towards a key role for environmental exposure in the causation of neurodegenerative disorders and specifically for metal exposure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X173098
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http://dx.doi.org/10.1016/j.jtemb.2018.11.007DOI Listing
March 2019
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The relationship between mercury exposure and epigenetic alterations regarding human health, risk assessment and diagnostic strategies.

J Trace Elem Med Biol 2019 Mar 14;52:37-47. Epub 2018 Nov 14.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Exposure to the environmental toxicants poses a serious threat to human health. The extent of exposure and the development of diseases are interrelated with each other. Chronic exposure to mercury (Hg) increases the risk of developing serious human disorders from embryo to adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183046
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http://dx.doi.org/10.1016/j.jtemb.2018.11.006DOI Listing
March 2019
3 Reads
2.491 Impact Factor

Aluminum and tin: Food contamination and dietary intake in an Italian population.

J Trace Elem Med Biol 2019 Mar 23;52:293-301. Epub 2019 Jan 23.

Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; Department of Epidemiology, Boston University School of Public Health, Boston, USA.

Aluminum and tin are ubiquitous in the environment. In normal biological systems, however, they are present only in trace amounts and have no recognized biological functions in humans. High exposure to these metals can result in adverse health effects such as neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.012DOI Listing

Hematoxylin assay of cupric chelation can give false positive results.

J Trace Elem Med Biol 2019 Mar 8;52:29-36. Epub 2018 Nov 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic. Electronic address:

Some compounds without apparent chelation sites have been shown to chelate cupric ions using the hematoxylin assay. Since these compounds also have reduction potential (direct antioxidant effect), the aim of this study was to determine the possible interference of reducing agents with the hematoxylin assay. Four different known reducing agents (hydroxylamine, vitamin C, trolox - a water-soluble form of vitamin E and reduced glutathione /GSH/) were selected for the study together with oxidized glutathione (GSSG) for comparison. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.022DOI Listing

Is the measurement of copper and iron in liver biopsies reliable? Results from a pilot external quality assurance scheme.

J Trace Elem Med Biol 2019 Mar 16;52:288-292. Epub 2019 Jan 16.

SAS Trace Element Centre, Surrey Research Park, 15 Frederick Sanger Road, Guildford, Surrey, GU2 7YD, UK. Electronic address:

The determination of copper and iron in liver biopsies have important roles in the diagnosis of Wilson's Disease and haemochromatosis respectively. An external quality assurance scheme is essential for analytical validation of results, however, none was available for these analytes at the time of this investigation. Accordingly a pilot scheme was established. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.009DOI Listing
March 2019
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Sub-acute oral exposure of zinc oxide nanoparticles causes alteration in iron homeostasis through acute phase response: A protective effect by surface modification.

J Trace Elem Med Biol 2019 Mar 14;52:270-287. Epub 2019 Jan 14.

Biochemistry Laboratory, Animal Facility, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanomaterials. Following oral exposure, these NPs can accumulate in various organs and induce the toxicity due to their physiochemical characteristics. In present study to reduce the toxicity, surface engineered ZnO NPs (c-ZnO NPs) were in-situ synthesized by using polyacrylamide grafted guar gum (PAm-g-GG) polymer in alkaline media. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.008DOI Listing
March 2019
2 Reads
2.491 Impact Factor

Reduction of hemoglobin, not iron, inhibited maturation of red blood cells in male rats exposed to high intensity endurance exercises.

J Trace Elem Med Biol 2019 Mar 11;52:263-269. Epub 2019 Jan 11.

Department of Naval Nutrition and Food Hygiene, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, China; Institute of International Medical Science and Technology, Sanda University, Shanghai, 201209, China. Electronic address:

The existence of sports anemia, induced by strenuous or long-term exercise and characterized by decreases of red blood cells (RBCs), hemoglobin and iron content, remains to be doubtful. To observe the effects of endurance exercise on RBCs and explain the underlying reason, we designed this study by observing RBCs parameters and iron metabolism in 8-weeks training rats and effects of iron supplement or protein supplement on RBCs. Results showed that erythrocyte counts, hematocrit, mean corpuscular volume and hemoglobin content decreased while RBC distribution width increased in exercised rats at later stage during 8 weeks training. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.006DOI Listing
March 2019
2.491 Impact Factor

Evaluation of trace elements associated with antioxidant enzymes in blood of primary epithelial ovarian cancer patients.

J Trace Elem Med Biol 2019 Mar 16;52:254-262. Epub 2019 Jan 16.

Hacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara 06100, Turkey. Electronic address:

Epithelial ovarian cancer (EOC) has been associated with oxidative stress (OS) due to epithelial inflammation which makes ovaries more vulnerable to the deleterious effects of reactive oxygen species (ROS). However, antioxidant enzymes (AOEs) such as manganese-superoxide dismutase (Mn-SOD), copper,zinc-superoxide dismutase (Cu,Zn-SOD) and glutathione peroxidase (GPx1) protect cells against the biological damage of ROS-induced OS and support cancer prevention by maintaining normal cell cycle progression, inhibiting proliferation, tumor invasion, angiogenesis, inflammation or inducing apoptosis. In the present study, we aimed to measure the levels of trace elements [manganese (Mn), copper (Cu), zinc (Zn) and selenium (Se)] which are structurally and/or functionally associated with the AOEs by inductively coupled plasma/mass-spectrometry (ICP/MS) in blood samples of patients with EOC (M, n = 26) and compare the data with healthy subjects (C, n = 46). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.010DOI Listing
March 2019
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Circulating levels of selenium-binding protein 1 (SELENBP1) are associated with risk for major adverse cardiac events and death.

J Trace Elem Med Biol 2019 Mar 12;52:247-253. Epub 2019 Jan 12.

Charité - Universitätsmedizin Berlin, Institut für Experimentelle Endokrinologie, Berlin, Germany. Electronic address:

Objective: Selenium-binding protein 1 (SELENBP1) is an intracellular protein with variable expression in response to cellular stress. As the selenium (Se) status is affected by inflammation and hypoxia, we hypothesized that SELENBP1 contributes to disease-specific Se metabolism. To test this hypothesis, a quantitative assay was developed and used to monitor SELENBP1 in patients with acute coronary syndrome (ACS). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.005DOI Listing
March 2019
2 Reads
2.491 Impact Factor

A soybean-based diet modulates cadmium-induced vascular apoptosis.

J Trace Elem Med Biol 2019 Mar 11;52:239-246. Epub 2019 Jan 11.

Laboratory of Experimental and Translational Medicine, Multidisciplinary Institute of Biological Research-San Luis, CCT-San Luis, CONICET-National University of San Luis, San Luis, 5700 San Luis, Argentina. Electronic address:

Cadmium (Cd) exposure has been associated with an increased risk of cardiovascular diseases. The diet is a modifiable source of protecting or damaging factors that may affect this risk. Herein we tested the hypothesis that a soybean-based diet (SBD) protects the vascular wall of the aorta against Cd-induced pro-inflammatory and pro-apoptotic effects. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.007DOI Listing

Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells.

J Trace Elem Med Biol 2019 Mar 9;52:232-238. Epub 2019 Jan 9.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Iron chelation has already been proposed to be a feasible strategy for cancer therapeutics in that reinforced iron demand is demonstrated in cancer cells, and quite a few iron chelators have been developed for this purpose. Desferrioxamine (DFO), an iron chelator approved by the U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183057
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http://dx.doi.org/10.1016/j.jtemb.2019.01.004DOI Listing
March 2019
4 Reads

Fatty acid levels alterations in THP-1 macrophages cultured with lead (Pb).

J Trace Elem Med Biol 2019 Mar 4;52:222-231. Epub 2019 Jan 4.

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 St., 70-111, Szczecin, Poland.

Objective: As cardiovascular events are one of the main causes of death in developed countries, each factor potentially increasing the risk of cardiovascular disease deserves special attention. One such factor is the potentially atherogenic effect of lead (Pb) on lipid metabolism, and is significant in view of the still considerable Pb environmental pollution and the non-degradability of Pb compounds.

Methods: Analysis of saturated fatty acids (SFA) (caprylic acid (C8:0), decanoic acid (C10:0), lauric acid (C12:0), tridecanoic acid (C13:0), myristic acid (C14:0), pentadecanoic acid (C15:0), palmitic acid (C16:0), heptadecanoic acid (C17:0), stearic acid (C18:0), and behenic acid (C22:0)), monounsaturated fatty acid (MUFA) (palmitoleic acid (C16:1), oleic acid (18:1w9), trans-vaccenic acid (C18:1 trans11)), and polyunsaturated fatty acid (PUFA) (linoleic acid (C18:2n6), gamma-linolenic acid (C18:3n6), arachidonic acid (C20:4n6)), was conducted by gas chromatography. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.003DOI Listing
March 2019
1 Read

Regular crabmeat consumers do not show increased urinary cadmium or beta-2-microglobulin levels compared to non-crabmeat consumers.

J Trace Elem Med Biol 2019 Mar 3;52:22-28. Epub 2018 Nov 3.

The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. Electronic address:

Cadmium (Cd) is a toxic metal that can be relatively high in brown meat from crab and there is concern that it may accumulate in long-term crabmeat consumers posing a health risk. Sixteen healthy habitual crabmeat consumers and twenty five healthy non-crabmeat consumers were recruited through completion of a seafood frequency questionnaire. Whole blood and urine samples were analysed for Cd levels and urinary beta-2-microglobulin, an established marker of Cd-induced kidney toxicity, to determine levels in crabmeat consumers. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.020DOI Listing
March 2019
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Zinc status and polycystic ovarian syndrome: A systematic review and meta-analysis.

J Trace Elem Med Biol 2019 Mar 4;52:216-221. Epub 2019 Jan 4.

Food Security Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Several studies have investigated serum zinc levels in patients with polycystic ovarian syndrome (PCOS), but the results of these studies remain inconclusive. Therefore, to derive a more precise estimation, we conducted a meta-analysis to investigate serum zinc concentrations in women with PCOS in comparison with healthy subjects. Electronic search was performed in PubMed, Scopus, and Google scholar up to April; 4, 2018 without any restriction. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.002DOI Listing
March 2019
2 Reads

Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults.

J Trace Elem Med Biol 2019 Mar 2;52:209-215. Epub 2019 Jan 2.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Trace elements, such as copper, zinc and selenium, have been linked to the development of metabolic syndrome. However, previous studies concerning these trace elements in association with metabolic syndrome have presented conflicting results in different countries. The aim of this study was to analyse the association between serum copper, zinc and selenium concentrations and the risk of metabolic syndrome among middle-aged and older Chinese adults. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.017DOI Listing

A multifunctional bis-(-)-nor-meptazinol-oxalamide hybrid with metal-chelating property ameliorates Cu(II)-induced spatial learning and memory deficits via preventing neuroinflammation and oxido-nitrosative stress in mice.

J Trace Elem Med Biol 2019 Mar 31;52:199-208. Epub 2018 Dec 31.

Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, PR China. Electronic address:

Excess copper exposure is a risk factor of neurodegeneration related to Alzheimer's disease (AD). Evidence indicates that, besides promoting amyloid β aggregation, activation of neuroinflammation and oxido-nitrosative stress (two key pathophysiological processes of AD) may also play important roles in Cu(II)-induced neuronal injury. Therefore, the copper-chelating strategy has gained attention in search for new anti-AD drugs. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.014DOI Listing

Countering the effects of lead as an environmental toxicant on the microanatomy of female reproductive system of adult wistar rats using aqueous extract of Ficus vogelii.

J Trace Elem Med Biol 2019 Mar 31;52:192-198. Epub 2018 Dec 31.

Department of Anatomy, Faculty of Basic medical Sciences, University of Nigeria Enugu Campus (UNEC), Enugu State, Nigeria.

Background: Lead without nutritional value is a widely studied occupational and environmental toxicant. Leads' toxic effects on female reproduction are decreased fertility, inability to sustain pregnancy and reduced pregnancy.

Objective: This study aimed at examining the effect of oral administration of lead acetate (1. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.016DOI Listing
March 2019
1 Read

The neurotoxic impact of subchronic exposure of male rats to copper oxychloride.

J Trace Elem Med Biol 2019 Mar 31;52:186-191. Epub 2018 Dec 31.

Zoology Department, Faculty of Science, Suez University, Suez, Egypt. Electronic address:

Background: The target of this animal study was to clarify the influence of Copper oxychloride (COC) (at concentrations of 50, 100 and 200 mg/kg b.wt.) administration for ninety days on the brain tissues to evaluate its possible neurotoxicity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183063
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http://dx.doi.org/10.1016/j.jtemb.2018.12.015DOI Listing
March 2019
5 Reads

Toxicological analysis of Pb and Cd by ET AAS in local anaesthetics for teething (teething gels) based on herbs available in Polish pharmacies.

J Trace Elem Med Biol 2019 Mar 10;52:18-21. Epub 2018 Nov 10.

Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, 30-387 Kraków, Poland; School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok, 690950, Russia.

Studies related to the toxicological analyses of metallic impurities in pharmaceuticals (drugs) is an important issue but there is a lack of refereed literature around the safety of teething remedies from herbal origin related to toxic metals impurities. In this article, the levels of Pb and Cd were measured in samples of local anaesthetics for teething (gels) based on herbs. This article was motivated by the fact that Pb and Cd are relevant toxic metals that may cause an adverse effect in babies even at low levels. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.005DOI Listing
March 2019
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Effects of sodium selenite and L-selenomethionine on feed intake, clinically relevant blood parameters and selenium species in plasma, colostrum and milk from high-yielding sows.

J Trace Elem Med Biol 2019 Mar 15;52:176-185. Epub 2018 Dec 15.

Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine, NMBU, Kyrkjevegen 332/334, NO-4325, Sandnes, Norway. Electronic address:

A field study in periparturient sows fed different dietary concentrations of either sodium selenite or L-selenomethionine (SeMet) was conducted to evaluate feed intake, haematological and biochemical parameters as well as to describe some key selenium (Se) species, namely selenoprotein P (SelP), selenoalbumin (SeAlb) and selenomethionine (SeMet) as well as total Se in plasma, colostrum and milk. Thirty-two sows were allotted to four treatments from 30 days (d) prepartum throughout on average a 32 d lactation period. Sodium selenite supplemented diets contained 0. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.009DOI Listing
March 2019
2 Reads

μXRF and LA-ICP-TQMS for quantitative bioimaging of iron in organ samples of a hemochromatosis model.

J Trace Elem Med Biol 2019 Mar 22;52:166-175. Epub 2018 Dec 22.

University of Münster, Institute of Inorganic and Analytical Chemistry, Corrensstraße 30, 48149 Münster, Germany. Electronic address:

Hereditary hemochromatosis is the most common autosomal recessive genetic disorder of the iron metabolism. Iron accumulation in various organs, especially in liver and pancreas leads to diseases and may cause organ failure. In this study, methods for elemental bioimaging by means of quantitative micro X-ray fluorescence analysis (μXRF) and laser ablation-inductively coupled plasma-triple quadrupole mass spectrometry (LA-ICP-TQMS) were developed and applied to investigate the pathophysiological development of iron accumulation in murine tissue based on animals with an iron-overload phenotype caused by a hepatocyte-specific genetic mutation. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.012DOI Listing
March 2019
4 Reads
2.491 Impact Factor

Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile.

J Trace Elem Med Biol 2019 Mar 30;52:157-165. Epub 2018 Dec 30.

Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL), CONICET, Ejército de Los Andes 950, CP D5700HHW, San Luis, Argentina. Electronic address:

The present study was conducted to investigate whether the deficiency of tumor necrosis factor receptor p55 (TNFRp55) modulates oxidative/nitrosative stress and metallomic profile into the peritoneal cavity during the experimental endometriosis progression in mice. Female C57BL/6 mice, wild-type (WT) and TNFRp55 knockout (KO) of two months were used. Endometriosis was induced experimentally by autotransplanting three pieces of the right uterine horn to the intestinal mesentery. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.013DOI Listing

Association between serum thallium in early pregnancy and risk of gestational diabetes mellitus: The Ma'anshan birth cohort study.

J Trace Elem Med Biol 2019 Mar 19;52:151-156. Epub 2018 Dec 19.

Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical University, Hefei, China. Electronic address:

Background: High blood glucose has been noted in case reports of acute thallium poisoning, however, effects of low-level exposure of thallium on risk of gestational diabetes mellitus (GDM) has not been explored yet.

Objectives: We aimed to explore the association of serum thallium concentration (STC) in early pregnancy and risk of GDM.

Methods: Data of 3013 women from the Ma'anshan birth cohort study (MABC), China was used. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.011DOI Listing
March 2019
2 Reads

Neurochemical dysfunction in motor cortex and hippocampus impairs the behavioral performance of rats chronically exposed to inorganic mercury.

J Trace Elem Med Biol 2019 Mar 14;52:143-150. Epub 2018 Dec 14.

Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil. Electronic address:

Chronic exposure to mercury chloride (HgCl) has been shown to promote oxidative stress and cell death in the central nervous system of adult rats displaying motor and cognitive impairments. However, there are no investigations about neurochemical function after this type of exposure in rodents that may be associated with those behavioral changes already reported. Thus, the aim of this study was to analyze glutamatergic and GABAergic dysfunctions in the motor cortex and hippocampus of adult rats, in a model of chronic exposure to HgCl in. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.008DOI Listing

Relationship between pre-pregnancy body mass index and mineral concentrations in serum and amniotic fluid in pregnant women during labor.

J Trace Elem Med Biol 2019 Mar 14;52:136-142. Epub 2018 Dec 14.

Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, ul. Wojska Polskiego 31, 60-624 Poznań, Poland. Electronic address:

The aim of the study was to determine the correlations between body mass index (BMI) values before pregnancy and the concentrations of selected elements (Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe) in blood serum and amniotic fluid (AF) in pregnant women. Elemental analysis of serum and amniotic fluid in 225 Polish women (Caucasian/white) showed a relationship between the concentration of minerals in the above-mentioned samples and the pre-pregnancy BMI. Analysis of blood serum was performed by using ICP-MS and it demonstrated that iron concentration was significantly lower in overweight and obese women. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.007DOI Listing
March 2019
1 Read

Cerium ion promotes the osteoclastogenesis through the induction of reactive oxygen species.

J Trace Elem Med Biol 2019 Mar 15;52:126-135. Epub 2018 Dec 15.

School of Biomedical Engineering and Medical Imaging, Third Military Medical University, China. Electronic address:

Cerium and cerium containing materials have been drawing increasing attentions in industrial and biomedical applications in recent decades. The increased applications of cerium have also increased the risk of human body exposed to cerium ions. Due to its similar ionic radius to calcium(II), cerium(III) have found mainly deposited in the skeletal system. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.006DOI Listing

Preparation, characterizations and in vitro cytotoxic activity of nickel oxide nanoparticles on HT-29 and SW620 colon cancer cell lines.

J Trace Elem Med Biol 2019 Mar 10;52:12-17. Epub 2018 Nov 10.

Pharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Despite the extensive implication of nickel oxide nanoparticles (NiO-NPs) in different fields such as biomedical science and industrial manufacturing, their effect on human cancer cells has not been elucidated. In this study, we report a simple process for the preparation of NiO-NPs. X-ray diffraction and transmission electron microscopy were used to characterize the surface architecture and dimension of the synthesized NiO-NPs. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.003DOI Listing
March 2019
2.491 Impact Factor

Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers.

J Trace Elem Med Biol 2019 Mar 15;52:118-125. Epub 2018 Dec 15.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Several studies have been conducted on liver damage caused by cadmium, but few on the protective effects of Ganoderma triterpenoids against liver damage due to cadmium. This experiment was designed to evaluate the protective effects of Ganoderma triterpenoids on the liver damage induced by cadmium in chickens. Eighty healthy seven-day-old Hyline male egg-laying chickens were randomly divided into four groups with 20 chickens in each group. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.010DOI Listing

Investigation of twelve trace elements in herbal tea commercialized in Brazil.

J Trace Elem Med Biol 2019 Mar 8;52:111-117. Epub 2018 Dec 8.

Institute of Chemistry, University of Campinas, P.O. Box 6154, 13083-970, Campinas, SP, Brazil.

In this study twelve trace elements were investigated in herbal tea commercialized in Brazil. Boldo, Chamomile, Mate and Peppermint tea samples were acquired in Brazil local markets and both herbs and their infusions were evaluated. Trace elements were classified in two groups: poorly (Al, As, Ba, Cd, Cr, Fe, Pb and Se) and moderately (Cu, Mn, Ni and Zn) extractable. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.004DOI Listing

Association between methylmercury environmental exposure and neurological disorders: A systematic review.

J Trace Elem Med Biol 2019 Mar 6;52:100-110. Epub 2018 Dec 6.

Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belem, Brazil. Electronic address:

The mercury-related central nervous system disorders have been extensively studied on animal models and human beings. However, clinical evidences of which neurological changes are in fact associated with mercury exposure remains controversial. This systematic review (Prospero registration under the number CRD42016041760) aimed to elucidate the association of methylmercury (MeHg) exposure with neurological alteration in populations living in MeHg-endemic risk area. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.001DOI Listing
March 2019
2 Reads

High serum arsenic and cardiovascular risk factors in patients undergoing continuous ambulatory peritoneal dialysis.

J Trace Elem Med Biol 2019 Mar 8;52:1-5. Epub 2018 Nov 8.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. Electronic address:

The present study aims to assess arsenic accumulation and explore its association with renal function and biomarkers of CVD risk in chronic kidney disease patients receiving continuous ambulatory peritoneal dialysis (CAPD). The serum was collected from 87 CAPD patients and 26 healthy subjects between 2015 and 2016. The arsenic concentration was measured by inductively coupled plasma mass spectrometer. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.002DOI Listing
March 2019
3 Reads

Use of Selenium-enriched olive leaves in the feed of growing rabbits: Effect on oxidative status, mineral profile and Selenium speciation of Longissimus dorsi meat.

J Trace Elem Med Biol 2019 Jan 6;51:98-105. Epub 2018 Oct 6.

Department of Agricultural, Environmental and Food Science, University of Perugia, Perugia, Italy.

In the present study the use of Selenium-fortified olive leaves as potential dietary source of Se in rabbit nutrition was evaluated. Sixty New Zealand White rabbits (35 days of age) were randomly assigned to the following dietary treatments: standard diet (C), and C supplemented with either 10% olive leaves (OL) or 10% Selenium-fortified olive leaves (SeOL; 100 mg/L of foliar spray sodium selenate solution). At 70 days of age, 10 rabbits per group were slaughtered and the oxidative status, mineral profile and Selenium speciation of Longissimus dorsi meat was analyzed. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.004DOI Listing
January 2019
5 Reads

Effects of green tea polyphenols on trace metals level of rats on food restriction and high-fat diet.

J Trace Elem Med Biol 2019 Jan 4;51:91-97. Epub 2018 Oct 4.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China. Electronic address:

Little evidence showed the interplay between tea and diet in the regulation of trace metal. Here, we examined the effects of green tea polyphenols (GTPs) on the level of trace elements (TEs) in rats on food restriction or high-fat diet. Thirty-six rats (Wistar, male) were randomly divided into 6 groups and fed on standard diet, food restriction and high-fat diet with or without GTPs (200 mg/kg bw/day) supplementation, respectively. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.002DOI Listing
January 2019
8 Reads

Mercury in dental amalgams: A great concern for clinical toxicology in developing countries?

J Trace Elem Med Biol 2019 Jan 6;51:9-11. Epub 2018 Sep 6.

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

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http://dx.doi.org/10.1016/j.jtemb.2018.09.002DOI Listing
January 2019
12 Reads
2.491 Impact Factor

The comparison of zinc, copper and iron levels in serum, aorta and left internal mammarian artery tissues in coronary by-pass graft surgery patients.

J Trace Elem Med Biol 2019 Jan 4;51:86-90. Epub 2018 Oct 4.

Biophysics Department, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkey. Electronic address:

Trace elements are crucial for vital enzymatic reactions in all metabolic processes. Zinc (Zn) acts as a co-factor for many enzymes. Copper (Cu) and iron (Fe) have pro-atherogenic effects resulting in atherosclerosis. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.003DOI Listing
January 2019
2 Reads

Comparison of serum essential trace metals between patients with schizophrenia and healthy controls.

J Trace Elem Med Biol 2019 Jan 5;51:79-85. Epub 2018 Oct 5.

Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, 100191, PR China; Vaccine Research Center, School of Public Health, Peking University, Beijing, 100191, PR China; Peking University Medical and Health Analysis Center, Peking University, Beijing, 100191, PR China. Electronic address:

Preclinical and clinical studies have suggested that essential trace metals (ETMs) play an important role in the pathophysiology of brain-based disorders, including schizophrenia. This case-control study aimed to evaluate the association between ETMs and schizophrenia, and to further examine the association between ETMs and clinical characteristics in schizophrenia. One-hundred and five (n = 105) subjects who meet DSM-IV criteria for schizophrenia between the ages of 18 and 40 were recruited for the study. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.009DOI Listing
January 2019
8 Reads
2.491 Impact Factor

The toxicological analysis of lead and cadmium in prescription food for special medical purposes and modified milk products for newborns and infants available in Polish pharmacies.

J Trace Elem Med Biol 2019 Jan 5;51:73-78. Epub 2018 Oct 5.

Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, 30-387 Kraków, Poland; School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok, 690950, Russia.

There is currently a lack of risk assessments around Pb and Cd in prescription food for special medical purposes (FSMPs) and modified milk products available in from pharmacies in Poland. This article describes and evaluates a toxicological analysis of lead and cadmium in prescription FSMPs (n = 6) and modified milk products (n = 6) available in Polish pharmacies. The metals were determined using electrothermal atomisation atomic absorption spectrometry. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.007DOI Listing
January 2019

A new ferrous diflunisal complex and its effects on biopools of labile iron.

J Trace Elem Med Biol 2019 Jan 2;51:65-72. Epub 2018 Oct 2.

Laboratory for Bioinorganic Chemistry and Metallodrugs, Brazil. Electronic address:

Drugs bearing metal-coordinating moieties can alter biological metal distribution. In this work, a complex between iron(II) and diflunisal was prepared in the solid state, exhibiting the following composition: [Fe(diflunisal)(HO)], (Fe(dif)). The ability of diflunisal to alter labile pools of both plasmatic and cellular iron was investigated in this work. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.001DOI Listing
January 2019
9 Reads

Selenium-biofortified corn peptides: Attenuating concanavalin A-Induced liver injury and structure characterization.

J Trace Elem Med Biol 2019 Jan 29;51:57-64. Epub 2018 Sep 29.

College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan 43000, China. Electronic address:

The relationship between hepatoprotective effects of selenium-biofortified corn (Zea mays Linn) peptides (SeCPs) and its antioxidant ability was evaluated and the structure of SeCPs was identified. SeCPs and corn peptides (CPs) both had good antioxidant ability, and the effect of SeCPs was significantly higher than CPs within a certain concentration range (P < 0.05). Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.09.010DOI Listing
January 2019
1 Read
2.491 Impact Factor

Quantitative dried blood spot analysis for metallodrugs by laser ablation-inductively coupled plasma-mass spectrometry.

J Trace Elem Med Biol 2019 Jan 27;51:50-56. Epub 2018 Sep 27.

Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 28/30, 48149, Münster, Germany. Electronic address:

A quantitative dried blood spot (DBS) method based on direct sampling by means of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) is presented. Gadolinium-based contrast agents were used as model metallodrugs with a significant relevance for pharmaceutical applications. Challenges regarding the ablation of the complex blood-filter matrix were characterized and successfully addressed by a thorough adaption of the laser ablation conditions. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.09.009DOI Listing
January 2019
7 Reads
2.491 Impact Factor

Quantitative trace element mapping in liver tissue from patients with Wilson`s disease determined by micro X-ray fluorescence.

J Trace Elem Med Biol 2019 Jan 27;51:42-49. Epub 2018 Sep 27.

Medizinische Universität Wien, Klinisches Institut für Klinische Pathologie, Austria.

Aims: of this investigation were to quantify copper (Cu), iron (Fe) and zinc (Zn) along with sulphur (S) and phosphorus (P) in hepatocytes and connective tissue in liver section from patients with Wilson´s disease (WD) by micro Synchrotron X-ray fluorescence (μ-SRXRF). Secondly to establish two-dimensional μ-SRXRF element mappings for comparison with histologically prepared slices, and thirdly to assess whether elemental distributions are associated.

Methods: Archival liver tissues from twelve patients with end-stage cirrhosis or fulminant WD were investigated. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.09.007DOI Listing
January 2019
5 Reads

Micronutrient content and antioxidant enzyme activities in human breast milk.

J Trace Elem Med Biol 2019 Jan 27;51:36-41. Epub 2018 Sep 27.

Centro de Investigaciones Biológicas del Noroeste (CIBNOR), S.C., Instituto Politécnico Nacional 195, Col. Playa Palo de Santa Rita Sur, La Paz, Baja California Sur, C.P. 23096, Mexico. Electronic address:

Breast milk contains micronutrients that function as cofactors of antioxidant enzymes. High concentrations of iron (Fe) and copper (Cu) can increase the production of reactive oxygen species (ROS). This study aimed to assess the relationship between the activity of antioxidant enzymes (superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST)) and the concentration of the micronutrients Fe, Cu and zinc (Zn) in breast milk. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.09.008DOI Listing
January 2019
11 Reads

Trace element profile in pemphigus foliaceus and in pemphigus vulgaris patients from Southeastern Brazil.

J Trace Elem Med Biol 2019 Jan 24;51:31-35. Epub 2018 Sep 24.

Laboratory of the Division of Dermatology, University Hospital, Ribeirão Preto Medical School, Avenida Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.

Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune bullous diseases; they are endemic in the northeastern region of the state of São Paulo, Southeastern Brazil. Patients' copper (Cu), zinc (Zn), and selenium (Se) metabolic deficiencies have already been associated with PV pathogenesis in the Middle East but not in Brazil. Lead (Pb), Cu, Zn, and Se concentrations were determined in whole blood or serum samples obtained from 56 PV patients, 62 PF patients, and 135 healthy controls from the endemic region and compared. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.09.005DOI Listing
January 2019
6 Reads