1,658 results match your criteria Journal of Trace Elements in Medicine and Biology[Journal]


Sex-dependent expression of metallothioneins MT1 and MT2 and concentrations of trace elements in rat liver and kidney tissues: Effect of gonadectomy.

J Trace Elem Med Biol 2019 May 23;53:98-108. Epub 2019 Feb 23.

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia. Electronic address:

Metallothioneins (MTs) exhibit binding affinity for several essential and toxic trace elements. Previous studies in rodents indicated sex differences in the hepatic and renal expression of MTs and concentrations of various elements. The mechanism responsible for these differences has not been resolved. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.010DOI Listing
May 2019
2.491 Impact Factor

Assessing the dietary intake of calcium, magnesium, iron, zinc and copper in institutionalised children and adolescents from Guatemala. Contribution of nutritional supplements.

J Trace Elem Med Biol 2019 May 21;53:91-97. Epub 2019 Feb 21.

Department of Physiology and Biochemistry of Animal Nutrition, Estación Experimental del Zaidín (CSIC), Granada, Spain.

In childhood and adolescence an adequate mineral intake is essential for normal growth and immune function, and to prevent chronic diseases in adulthood. The aim of this study was to analyse the dietary intake of Ca, Mg, Fe, Zn and Cu in children and adolescents from an orphanage-school in Guatemala and to assess the mineral contribution of nutritional supplements used by this population. Mineral content was analysed in nutritional supplements, bioaccesible fractions obtained after an in vitro gastrointestinal method, and diets sampled by a 7-day duplicate diet study. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.009DOI Listing

Assessment of 7 trace elements in serum of patients with nontuberculous mycobacterial lung disease.

J Trace Elem Med Biol 2019 May 12;53:84-90. Epub 2019 Feb 12.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Pharmacology & Therapeutics, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Nontuberculous mycobacterial (NTM) lung diseases are an emerging cause of pulmonary infection, becoming more common in the clinical setting as incidence of NTM lung diseases steadily increases worldwide. Trace elements are essential micronutrients and are known to play many important roles in infectious diseases. We investigated the concentrations of trace elements in patients with NTM lung disease and compared these values to patients with pulmonary tuberculosis and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.004DOI Listing

Rutin abrogates manganese-Induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway.

J Trace Elem Med Biol 2019 May 24;53:8-15. Epub 2019 Jan 24.

Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Excess exposure to Manganese (Mn) promotes oxidative stress and neuro-inflammation. Rutin (RUT) has been found to exhibit both anti-oxidative stress and anti-inflammatory properties. This study aimed to investigate the effects of RUT on Mn accumulation, endogenous iron (Fe) depletion, oxidative stress, inflammation and nuclear factor kappa B (NF-κB) signaling pathways in the hippocampus and striatum of Mn - induced rats. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.014DOI Listing
May 2019
1 Read

Measurement of the enriched stable isotope Fe in iron related disorders- comparison of INAA and MC-ICP-MS.

J Trace Elem Med Biol 2019 May 10;53:77-83. Epub 2019 Feb 10.

Delft University of Technology, Mekelweg 15, 2629 JB, Delft, the Netherlands.

As a safer alternative for the use of radioactive tracers, the enriched stable Fe isotope has been introduced in studies of iron metabolism. In this study this isotope is measured with instrumental neutron activation analysis (INAA) in blood samples of patients with iron related disorders and controls after oral ingestion of a Fe containing pharmaceutical. Results were compared with those derived from MC-ICP-MS, applied on the same samples, and analytical and practical aspects of the two techniques were compared. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.001DOI Listing
May 2019
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Blood metals, age related macular degeneration and contrast sensitivity impairment.

Authors:
Tomoyuki Kawada

J Trace Elem Med Biol 2019 May 18;53:76. Epub 2019 Feb 18.

Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo 113-8602, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jtemb.2019.02.008DOI Listing
May 2019
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Urinary ionomic analysis reveals new relationship between minerals and longevity in a Han Chinese population.

J Trace Elem Med Biol 2019 May 12;53:69-75. Epub 2019 Feb 12.

Shenzhen Key Laboratory of Marine Bioresources and Ecology, Brain Disease and Big Data Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, Guangdong, PR China. Electronic address:

Human longevity involves genetic, nutritional, environmental and many other factors playing a key role in healthy aging. Previous studies have shown that mineral metabolism and homeostasis are associated with lifespan extension. However, the majority of them have focused on a limited number of elements and ignored the complex relationship between them. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.002DOI Listing
May 2019
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Zebrafish exposure to diphenyl diselenide-loaded polymeric nanocapsules caused no behavioral impairments and brain oxidative stress.

J Trace Elem Med Biol 2019 May 15;53:62-68. Epub 2019 Feb 15.

Laboratório de Tecnologia Farmacêutica, Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Previous findings showed that the nanoencapsulation of diphenyl diselenide [(PhSe)], an organoselenium compound, provided superior biological effects and lower toxicological potential than its free form in vitro. However, few studies reported the behavioral and biochemical effects of this nanocapsules formulation in vivo. Zebrafish (Danio rerio) has emerged as a useful animal model to determine the pharmacological and toxicological effects of nanoparticles. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.005DOI Listing

Sex-specific effects of blood cadmium on thyroid hormones and thyroid function status: Korean nationwide cross-sectional study.

J Trace Elem Med Biol 2019 May 12;53:55-61. Epub 2019 Feb 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam College of Medicine, Daegu, Republic of Korea. Electronic address:

Previous studies on blood cadmium (BCd) and changes in thyroid hormone levels are controversial. We investigated whether thyroid hormone levels and thyroid function status were associated with BCd according to sex in the Korean population. Our study included 1972 participants based on the 2013 Korea National Health and Nutrition Examination Survey (KNHANES) data. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.003DOI Listing
May 2019
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The combined effects of Cr(III) propionate complex supplementation and iron excess on copper and zinc status in rats.

Authors:
Halina Staniek

J Trace Elem Med Biol 2019 May 10;53:49-54. Epub 2019 Feb 10.

Institute of Human Nutrition and Dietetics, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-624 Poznań, Poland. Electronic address:

It is suggested that both iron overload and chromium(III) deficiency may be risk factors of diabetes. It seems that both Fe and Cr(III) metabolism as well as copper and zinc metabolism are interrelated. However, the direction of these changes may depend on mutual proportions of these elements in the diet and organism. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.011DOI Listing
May 2019
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The association of serum zinc and copper with hypertension: A meta-analysis.

J Trace Elem Med Biol 2019 May 1;53:41-48. Epub 2019 Feb 1.

Department of Epidemiology and Health Statistics, The Medical College of Qingdao University, Qingdao, Shandong Province, China. Electronic address:

Objective: The association of serum zinc (Zn), copper (Cu) with the risk of hypertension (HT) remains controversial. Therefore, we conducted a meta-analysis to explore the relationships.

Methods: We searched relevant literatures on PubMed and Web of Science up to September 2018. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.018DOI Listing
May 2019
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Organoselenotriazoles attenuate oxidative damage induced by mitochondrial dysfunction in mev-1 Caenorhabditis elegans mutants.

J Trace Elem Med Biol 2019 May 31;53:34-40. Epub 2019 Jan 31.

Programa de Pós-Graduação em Bioquímica, Laboratório de Bioquímica e Toxicologia em Caenorhabditis elegans (GBTOXce), Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS 97500-970, Brazil. Electronic address:

Organic selenium compounds have several pharmacological activities already described, as anti-inflammatory and antitumor activities, which have been attributed to their antioxidant effects. Because they are promising in pharmacology, the synthesis of these compounds has increased significantly. As many new molecules are synthesized the use of a simple model like Caenorhabditis elegans is highly advantageous for initial evaluation of the toxicity and therapeutic potential of these molecules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183050
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http://dx.doi.org/10.1016/j.jtemb.2019.01.017DOI Listing
May 2019
3 Reads

In vitro gastrointestinal digestion to evaluate the total, bioaccessible and bioavailable concentrations of iron and manganese in açaí (Euterpe oleracea Mart.) pulps.

J Trace Elem Med Biol 2019 May 29;53:27-33. Epub 2019 Jan 29.

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo - USP, Avenida do Café s/n, Monte Alegre, 14040-903, Ribeirão Preto, SP, Brazil.

Açaí pulp consumption has increased in Brazil and worldwide. Recently, a high average content of manganese (450 mg/kg) was observed in açaí pulp, raising the hypothesis of toxicological effects associated to its ingestion. However, the total concentration of an element does not reflect the real benefits and risks of consuming a food. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.016DOI Listing

Absorption of strontium by foods prepared in drinking water.

J Trace Elem Med Biol 2019 May 4;53:22-26. Epub 2019 Jan 4.

Office of Science and Technology, Office of Water, U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, Mail Code 4304T, Washington, DC, 20460, USA. Electronic address:

Strontium (Sr) is a natural element, ubiquitous in the environment and known to occur in water, food, air, and soils. Strontium is present in media as a salt or an ionized divalent cation. The Sr ion (dissociated) is toxicokinetically important because it is easily absorbed into systemic circulation when inhaled with particulates or ingested with water or foods. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436642PMC

High iodine intake and central lymph node metastasis risk of papillary thyroid cancer.

J Trace Elem Med Biol 2019 May 25;53:16-21. Epub 2019 Jan 25.

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

The relationship between iodine intake and clinicopathologic characteristics of papillary thyroid cancer (PTC) is unclear. We aim to investigate the relationship between iodine intake and central lymph node metastasis (CLNM) of PTC. A total of 4040 consecutive patients with PTC receiving thyroidectomy and central lymph node dissection were enrolled from 2013 to 2018. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.015DOI Listing
May 2019
1 Read

Selenium and selenium species in the etiology of Alzheimer's dementia: The potential for bias of the case-control study design.

J Trace Elem Med Biol 2019 May 7;53:154-162. Epub 2019 Mar 7.

Center for Neurosciences and Neurotechnology, Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, 287 Via Campi, Modena 41125, Italy; Department of Neurosciences, Azienda Ospedaliero-Universitaria di Modena, 71 Via del Pozzo, Modena 41124, Italy.

Several human studies imply that the trace element selenium and its species may influence the onset of neurological disease, including Alzheimer's dementia (AD). Nevertheless, the literature is conflicting, with reported associations between exposure and risk in opposite direction, possibly due to biases in exposure assessment. After conducting a cohort study that detected an excess AD risk associated with higher levels of inorganic-hexavalent selenium in subjects with mild cognitive impairment (MCI), we investigated the relation between selenium and AD using a case-control study design. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.03.002DOI Listing
May 2019
1 Read

Environmental boron exposure does not induce DNA damage in lymphocytes and buccal cells of females: DNA damage in lymphocytes and buccal cells of boron exposed females.

J Trace Elem Med Biol 2019 May 9;53:150-153. Epub 2019 Mar 9.

Leibniz Research Center for Working Environment and Human Factors (IfADo), Ardey Str. 67, 44139 Dortmund, Germany.

Boron (B) compounds are essential for plants and animals and beneficial for humans in nutritional amounts. I animals and humans increasing evidence have shown beneficial effects on B compounds on nutrition and on antioxidant status. The genotoxic effects of environmental B exposure in women living in boron-rich and boron-poor areas was examined in this study. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.03.004DOI Listing
May 2019
1 Read

The analysis of Cu, Mn and Zn content in prescription food for special medical purposes and modified milk products for newborns and infants available in Polish pharmacies from toxicological and nutritional point of view.

J Trace Elem Med Biol 2019 May 7;53:144-149. Epub 2019 Mar 7.

Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, 30-387 Kraków, Poland; School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok, 690950, Russia.

Background: Prescription food for special medical purposes (FSMPs) and modified milk products (MMPs), available in pharmacies, are important for newborns and infants that are not breastfed. In the scientific literature there is a lack of comprehensive studies and corresponding safety assessment of the essential trace elements in these products.

Objective: The aim of this article was determination of Cu, Mn and Zn levels in the most frequently available prescription FSMPs (n = 6) and MMPs (n = 6) available in Polish pharmacies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X193002
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http://dx.doi.org/10.1016/j.jtemb.2019.03.001DOI Listing
May 2019
6 Reads

Boron and pigment content in alfalfa affected by nano fertilization under calcareous conditions.

J Trace Elem Med Biol 2019 May 28;53:136-143. Epub 2019 Feb 28.

Associate Professor of Agronomy, Faculty of Agriculture, Shahed University, Tehran, Iran.

Boron is among the necessary nutrients for plant growth and yield production, and it can improve the nutritional properties of forage crops. However, at higher levels it maybe toxic adversely affecting plant growth and forage quality. Plant boron concentration is affected by different parameters including boron fertilization, soil, climate, plant species, etc. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.014DOI Listing
May 2019
1 Read

Monitoring of salt iodisation programme in Iran; Health outcomes, shortages and perspective.

J Trace Elem Med Biol 2019 May 2;53:135. Epub 2019 Mar 2.

Department of Clinical Nutrition, The First People's Hospital of Wujiang District, Suzhou, China.

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183071
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http://dx.doi.org/10.1016/j.jtemb.2019.02.012DOI Listing
May 2019
2 Reads

Levels of serum trace elements in patients with primary open-angle glaucoma.

J Trace Elem Med Biol 2019 May 15;53:129-134. Epub 2019 Feb 15.

Department of Ophthalmology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:

Purpose: Glaucoma disease is known as multifactorial. Trace elements seemed to be linked via oxidative stress mediated changes to the complex glaucoma pathophysiology. Thus, it was the aim of this study to investigate serum levels of trace elements in primary open-angle glaucoma patients (POAG). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.006DOI Listing

Blood titanium level as a biomarker of orthopaedic implant wear.

J Trace Elem Med Biol 2019 May 28;53:120-128. Epub 2019 Feb 28.

Institute of Orthopaedics and Musculoskeletal Science, University College London, HA7 4LP, Stanmore, UK; Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, UK.

Background: Joint replacement implants are usually manufactured from cobalt-chromium or titanium alloys. After the device is implanted, wear and corrosion generate metal particles and ions, which are released into local tissue and blood. The metal debris can cause a range of adverse local and systemic effects in patients. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.013DOI Listing

Chronic copper treatment prevents the liver critical balance transcription response induced by acetaminophen.

J Trace Elem Med Biol 2019 May 21;53:113-119. Epub 2019 Feb 21.

Gastroenterología y Nutrición, INTA, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile. Electronic address:

The independent toxic effects of copper and acetaminophen are among the most studied topics in liver toxicity. Here, in an animal model of Cebus capucinus chronically exposed to high dietary copper, we assessed clinical and global transcriptional adaptations of the liver induced by a single high dose of acetaminophen. The experiment conditions were chosen to resemble a close to human real-life situation of exposure to both toxic stimuli. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.007DOI Listing
May 2019
1 Read

The toxicological analysis of Cu, Mn and Zn as elemental impurities in pharmaceutical herbal products for teething available in pharmacies in Poland.

J Trace Elem Med Biol 2019 May 26;53:109-112. Epub 2019 Feb 26.

Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, 30 - 387 Kraków, Poland; School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok, 690950, Russia.

The monitoring of elemental impurities (EIs) in pharmaceutical materials is often not adequately treated, although it is a very important topic because the directive ICH Q3D requires a wide range of elements, often at low concentrations, to be monitored. This article describes the quantitative toxicological analysis of copper, manganese and zinc as EIs in the pharmaceutical gels for teething containing herbs available in Poland. The levels of EIs were measured to evaluate whether the intake of these metals through the gels was within recommended levels. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.011DOI Listing
May 2019
4 Reads

Hepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamide.

J Trace Elem Med Biol 2019 May 23;53:1-7. Epub 2019 Jan 23.

Eskişehir Osmangazi University, Faculty of Science and Letters, Department of Biology, 26480, Eskişehir, Turkey.

This study aims to examine cyclophosphamide (CP) exsposure associated toxicity on rat livers and the likely defensive effects of boric acid (BA). The rats used in this study were divided into four groups: control group, CP group, BA group, and BA + CP group. The present study was carried out using routine histological H&E stain, immunohistochemical stain caspase-3 as apoptotic marker, serum biochemical analysis for liver function markers (alanine transaminase (ALT), aspartate transaminase (AST) and alkalen phosphatase (ALP)), oxidative stress markers (total oxidant status (TOS), oxidative stress index (OSI) and total antioxidant capacity marker (TAC)). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.013DOI Listing
May 2019
1 Read

Increasing selenium supply for heat-stressed or actively cooled sows improves piglet preweaning survival, colostrum and milk composition, as well as maternal selenium, antioxidant status and immunoglobulin transfer.

J Trace Elem Med Biol 2019 Mar 29;52:89-99. Epub 2018 Nov 29.

Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:

This study aimed to evaluate the effects of increasing selenium (Se) supply for heat-stressed or actively cooled sows on sow productivity, colostrum and milk composition, as well as the selenium and antioxidant status and immunoglobulin levels of sows and nursing piglets. The study was a 2 × 2 factorial design, where the first factor was farrowing environment [heat stress vs. actively cooling, temperature: 29. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183044
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http://dx.doi.org/10.1016/j.jtemb.2018.11.010DOI Listing
March 2019
9 Reads

Association between serum selenium level and the prevalence of diabetes mellitus in U.S. population.

J Trace Elem Med Biol 2019 Mar 10;52:83-88. Epub 2018 Dec 10.

Department of Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea. Electronic address:

Objective: Selenium seems to be a risk factor for diabetes mellitus (DM) in recent studies, opposite to the previous expectation that it may contribute to prevent DM. The authors aimed to ascertain the relationship between selenium and DM.

Methods: Data were collected from the National Health and Nutrition Examination Survey conducted from 2011 to 2014. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.005DOI Listing
March 2019
2 Reads
2.491 Impact Factor

Cadmium-induced hepatocellular injury: Modulatory effects of γ-glutamyl cysteine on the biomarkers of inflammation, DNA damage, and apoptotic cell death.

J Trace Elem Med Biol 2019 Mar 7;52:74-82. Epub 2018 Dec 7.

Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Taif 21974, Saudi Arabia.

Cadmium is an extremely toxic pollutant that reaches human body through intake of the industrially polluted food and water as well as through cigarette smoking and exposure to polluted air. Cadmium accumulates in different body organs especially the liver. It induces tissue injury largely through inflammation and oxidative stress-based mechanisms. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.003DOI Listing
March 2019
1 Read

Predicting iron absorption from an effervescent iron supplement in obese patients before and after Roux-en-Y gastric bypass: a preliminary study.

J Trace Elem Med Biol 2019 Mar 7;52:68-73. Epub 2018 Dec 7.

KU Leuven, Clinical and Experimental Endocrinology, and University Hospitals Leuven/KU Leuven, Campus Gasthuisberg, Leuven, Belgium. Electronic address:

Background & Aims: Oral iron absorption is hampered in obese and bariatric patients, especially after Roux-en-Y gastric bypass (RYGB). As a result, iron deficiency, which is common in both patient groups, can be difficult to treat by oral supplements, often necessitating a switch to parenteral administration. The aim of this study was to find possible predictors of the extent of absorption of an effervescent iron gluconate oral supplement, which enables to pre-emptively identify those patients in which oral supplementation is likely to fail. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.002DOI Listing
March 2019
4 Reads

Monitoring of salt iodisation programme in Iran; Health outcomes, shortages and perspective.

J Trace Elem Med Biol 2019 Mar 10;52:6-11. Epub 2018 Nov 10.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Centre for Water Quality Research (CWQI), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Iodine deficiency disorders include a wide range of metabolic and nonmetabolic disorders including goiter. To control IDDs, the World Health Organization and responsible agencies in countries established daily iodine uptake. Almost all the countries in the world provide the required iodine through salt iodisation. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.004DOI Listing
March 2019
3 Reads

Suppression of proliferation and activation of cell death by sodium selenite involves mitochondria and lysosomes in chemoresistant bladder cancer cells.

J Trace Elem Med Biol 2019 Mar 27;52:58-67. Epub 2018 Nov 27.

Department of Medical Biology and Genetics Charles University, Faculty of Medicine in Hradec Králové, Zborovská 2089, 500 03 Hradec Králové, Czech Republic. Electronic address:

The specific effects of sodium selenite (selenite) on a chemoresistant human bladder cancer cell line RT-112/D21 were investigated during 72 h. Selenite at low concentration of 2.5 μmol (otherwise tolerated in normal urothelial cells UROtsa) suppressed growth and proliferation of the tested cancer cells via induced oxidative stress. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.009DOI Listing
March 2019
1 Read

Variation in trace element content between liver lobes in cattle. How important is the sampling site?

J Trace Elem Med Biol 2019 Mar 20;52:53-57. Epub 2018 Nov 20.

Department of Animal Pathology, Faculty of Veterinary Medicine, Universidade de Santiago de Compostela, 27002 Lugo, Spain.

The aim of the present study was to establish the pattern of lobular distribution of trace elements in the liver of cattle. The objective was to determine which part of the liver would provide accurate estimation of the trace element content of the whole organ. Liver samples were obtained from 10 Holstein-Friesian (HF), 10 Galician Blond (GB) and 10 GBxHF crosses (all aged 10 months) at slaughter. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.11.008DOI Listing
March 2019
3 Reads

Ultraclean paired sampling for metal analysis in neurodegenerative disorders.

Authors:
Per M Roos

J Trace Elem Med Biol 2019 Mar 15;52:48-52. Epub 2018 Nov 15.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Physiology, Capio St.Göran Hospital, Stockholm, Sweden. Electronic address:

The causes of neurodegenerative disorders are largely unknown. Environmental factors seem to contribute to neurodegeneration in genetically susceptible individuals. Increasing evidence point towards a key role for environmental exposure in the causation of neurodegenerative disorders and specifically for metal exposure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X173098
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http://dx.doi.org/10.1016/j.jtemb.2018.11.007DOI Listing
March 2019
5 Reads

The relationship between mercury exposure and epigenetic alterations regarding human health, risk assessment and diagnostic strategies.

J Trace Elem Med Biol 2019 Mar 14;52:37-47. Epub 2018 Nov 14.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Exposure to the environmental toxicants poses a serious threat to human health. The extent of exposure and the development of diseases are interrelated with each other. Chronic exposure to mercury (Hg) increases the risk of developing serious human disorders from embryo to adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183046
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http://dx.doi.org/10.1016/j.jtemb.2018.11.006DOI Listing
March 2019
10 Reads
2.491 Impact Factor

Aluminum and tin: Food contamination and dietary intake in an Italian population.

J Trace Elem Med Biol 2019 Mar 23;52:293-301. Epub 2019 Jan 23.

Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; Department of Epidemiology, Boston University School of Public Health, Boston, USA.

Aluminum and tin are ubiquitous in the environment. In normal biological systems, however, they are present only in trace amounts and have no recognized biological functions in humans. High exposure to these metals can result in adverse health effects such as neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.012DOI Listing
March 2019
1 Read

Hematoxylin assay of cupric chelation can give false positive results.

J Trace Elem Med Biol 2019 Mar 8;52:29-36. Epub 2018 Nov 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic. Electronic address:

Some compounds without apparent chelation sites have been shown to chelate cupric ions using the hematoxylin assay. Since these compounds also have reduction potential (direct antioxidant effect), the aim of this study was to determine the possible interference of reducing agents with the hematoxylin assay. Four different known reducing agents (hydroxylamine, vitamin C, trolox - a water-soluble form of vitamin E and reduced glutathione /GSH/) were selected for the study together with oxidized glutathione (GSSG) for comparison. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.022DOI Listing

Is the measurement of copper and iron in liver biopsies reliable? Results from a pilot external quality assurance scheme.

J Trace Elem Med Biol 2019 Mar 16;52:288-292. Epub 2019 Jan 16.

SAS Trace Element Centre, Surrey Research Park, 15 Frederick Sanger Road, Guildford, Surrey, GU2 7YD, UK. Electronic address:

The determination of copper and iron in liver biopsies have important roles in the diagnosis of Wilson's Disease and haemochromatosis respectively. An external quality assurance scheme is essential for analytical validation of results, however, none was available for these analytes at the time of this investigation. Accordingly a pilot scheme was established. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.009DOI Listing
March 2019
2 Reads

Sub-acute oral exposure of zinc oxide nanoparticles causes alteration in iron homeostasis through acute phase response: A protective effect by surface modification.

J Trace Elem Med Biol 2019 Mar 14;52:270-287. Epub 2019 Jan 14.

Biochemistry Laboratory, Animal Facility, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address:

Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanomaterials. Following oral exposure, these NPs can accumulate in various organs and induce the toxicity due to their physiochemical characteristics. In present study to reduce the toxicity, surface engineered ZnO NPs (c-ZnO NPs) were in-situ synthesized by using polyacrylamide grafted guar gum (PAm-g-GG) polymer in alkaline media. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.008DOI Listing
March 2019
3 Reads
2.491 Impact Factor

Reduction of hemoglobin, not iron, inhibited maturation of red blood cells in male rats exposed to high intensity endurance exercises.

J Trace Elem Med Biol 2019 Mar 11;52:263-269. Epub 2019 Jan 11.

Department of Naval Nutrition and Food Hygiene, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, China; Institute of International Medical Science and Technology, Sanda University, Shanghai, 201209, China. Electronic address:

The existence of sports anemia, induced by strenuous or long-term exercise and characterized by decreases of red blood cells (RBCs), hemoglobin and iron content, remains to be doubtful. To observe the effects of endurance exercise on RBCs and explain the underlying reason, we designed this study by observing RBCs parameters and iron metabolism in 8-weeks training rats and effects of iron supplement or protein supplement on RBCs. Results showed that erythrocyte counts, hematocrit, mean corpuscular volume and hemoglobin content decreased while RBC distribution width increased in exercised rats at later stage during 8 weeks training. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.006DOI Listing
March 2019
1 Read
2.491 Impact Factor

Evaluation of trace elements associated with antioxidant enzymes in blood of primary epithelial ovarian cancer patients.

J Trace Elem Med Biol 2019 Mar 16;52:254-262. Epub 2019 Jan 16.

Hacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara 06100, Turkey. Electronic address:

Epithelial ovarian cancer (EOC) has been associated with oxidative stress (OS) due to epithelial inflammation which makes ovaries more vulnerable to the deleterious effects of reactive oxygen species (ROS). However, antioxidant enzymes (AOEs) such as manganese-superoxide dismutase (Mn-SOD), copper,zinc-superoxide dismutase (Cu,Zn-SOD) and glutathione peroxidase (GPx1) protect cells against the biological damage of ROS-induced OS and support cancer prevention by maintaining normal cell cycle progression, inhibiting proliferation, tumor invasion, angiogenesis, inflammation or inducing apoptosis. In the present study, we aimed to measure the levels of trace elements [manganese (Mn), copper (Cu), zinc (Zn) and selenium (Se)] which are structurally and/or functionally associated with the AOEs by inductively coupled plasma/mass-spectrometry (ICP/MS) in blood samples of patients with EOC (M, n = 26) and compare the data with healthy subjects (C, n = 46). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.010DOI Listing
March 2019
2 Reads
2.491 Impact Factor

Circulating levels of selenium-binding protein 1 (SELENBP1) are associated with risk for major adverse cardiac events and death.

J Trace Elem Med Biol 2019 Mar 12;52:247-253. Epub 2019 Jan 12.

Charité - Universitätsmedizin Berlin, Institut für Experimentelle Endokrinologie, Berlin, Germany. Electronic address:

Objective: Selenium-binding protein 1 (SELENBP1) is an intracellular protein with variable expression in response to cellular stress. As the selenium (Se) status is affected by inflammation and hypoxia, we hypothesized that SELENBP1 contributes to disease-specific Se metabolism. To test this hypothesis, a quantitative assay was developed and used to monitor SELENBP1 in patients with acute coronary syndrome (ACS). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.005DOI Listing
March 2019
2 Reads
2.491 Impact Factor

A soybean-based diet modulates cadmium-induced vascular apoptosis.

J Trace Elem Med Biol 2019 Mar 11;52:239-246. Epub 2019 Jan 11.

Laboratory of Experimental and Translational Medicine, Multidisciplinary Institute of Biological Research-San Luis, CCT-San Luis, CONICET-National University of San Luis, San Luis, 5700 San Luis, Argentina. Electronic address:

Cadmium (Cd) exposure has been associated with an increased risk of cardiovascular diseases. The diet is a modifiable source of protecting or damaging factors that may affect this risk. Herein we tested the hypothesis that a soybean-based diet (SBD) protects the vascular wall of the aorta against Cd-induced pro-inflammatory and pro-apoptotic effects. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.007DOI Listing
March 2019
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Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells.

J Trace Elem Med Biol 2019 Mar 9;52:232-238. Epub 2019 Jan 9.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Iron chelation has already been proposed to be a feasible strategy for cancer therapeutics in that reinforced iron demand is demonstrated in cancer cells, and quite a few iron chelators have been developed for this purpose. Desferrioxamine (DFO), an iron chelator approved by the U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183057
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http://dx.doi.org/10.1016/j.jtemb.2019.01.004DOI Listing
March 2019
10 Reads

Fatty acid levels alterations in THP-1 macrophages cultured with lead (Pb).

J Trace Elem Med Biol 2019 Mar 4;52:222-231. Epub 2019 Jan 4.

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 St., 70-111, Szczecin, Poland.

Objective: As cardiovascular events are one of the main causes of death in developed countries, each factor potentially increasing the risk of cardiovascular disease deserves special attention. One such factor is the potentially atherogenic effect of lead (Pb) on lipid metabolism, and is significant in view of the still considerable Pb environmental pollution and the non-degradability of Pb compounds.

Methods: Analysis of saturated fatty acids (SFA) (caprylic acid (C8:0), decanoic acid (C10:0), lauric acid (C12:0), tridecanoic acid (C13:0), myristic acid (C14:0), pentadecanoic acid (C15:0), palmitic acid (C16:0), heptadecanoic acid (C17:0), stearic acid (C18:0), and behenic acid (C22:0)), monounsaturated fatty acid (MUFA) (palmitoleic acid (C16:1), oleic acid (18:1w9), trans-vaccenic acid (C18:1 trans11)), and polyunsaturated fatty acid (PUFA) (linoleic acid (C18:2n6), gamma-linolenic acid (C18:3n6), arachidonic acid (C20:4n6)), was conducted by gas chromatography. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.003DOI Listing
March 2019
4 Reads

Regular crabmeat consumers do not show increased urinary cadmium or beta-2-microglobulin levels compared to non-crabmeat consumers.

J Trace Elem Med Biol 2019 Mar 3;52:22-28. Epub 2018 Nov 3.

The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. Electronic address:

Cadmium (Cd) is a toxic metal that can be relatively high in brown meat from crab and there is concern that it may accumulate in long-term crabmeat consumers posing a health risk. Sixteen healthy habitual crabmeat consumers and twenty five healthy non-crabmeat consumers were recruited through completion of a seafood frequency questionnaire. Whole blood and urine samples were analysed for Cd levels and urinary beta-2-microglobulin, an established marker of Cd-induced kidney toxicity, to determine levels in crabmeat consumers. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.10.020DOI Listing
March 2019
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Zinc status and polycystic ovarian syndrome: A systematic review and meta-analysis.

J Trace Elem Med Biol 2019 Mar 4;52:216-221. Epub 2019 Jan 4.

Food Security Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Several studies have investigated serum zinc levels in patients with polycystic ovarian syndrome (PCOS), but the results of these studies remain inconclusive. Therefore, to derive a more precise estimation, we conducted a meta-analysis to investigate serum zinc concentrations in women with PCOS in comparison with healthy subjects. Electronic search was performed in PubMed, Scopus, and Google scholar up to April; 4, 2018 without any restriction. Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.01.002DOI Listing
March 2019
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Association of serum copper, zinc and selenium levels with risk of metabolic syndrome: A nested case-control study of middle-aged and older Chinese adults.

J Trace Elem Med Biol 2019 Mar 2;52:209-215. Epub 2019 Jan 2.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Trace elements, such as copper, zinc and selenium, have been linked to the development of metabolic syndrome. However, previous studies concerning these trace elements in association with metabolic syndrome have presented conflicting results in different countries. The aim of this study was to analyse the association between serum copper, zinc and selenium concentrations and the risk of metabolic syndrome among middle-aged and older Chinese adults. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.017DOI Listing

A multifunctional bis-(-)-nor-meptazinol-oxalamide hybrid with metal-chelating property ameliorates Cu(II)-induced spatial learning and memory deficits via preventing neuroinflammation and oxido-nitrosative stress in mice.

J Trace Elem Med Biol 2019 Mar 31;52:199-208. Epub 2018 Dec 31.

Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, PR China. Electronic address:

Excess copper exposure is a risk factor of neurodegeneration related to Alzheimer's disease (AD). Evidence indicates that, besides promoting amyloid β aggregation, activation of neuroinflammation and oxido-nitrosative stress (two key pathophysiological processes of AD) may also play important roles in Cu(II)-induced neuronal injury. Therefore, the copper-chelating strategy has gained attention in search for new anti-AD drugs. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.014DOI Listing
March 2019
7 Reads

Countering the effects of lead as an environmental toxicant on the microanatomy of female reproductive system of adult wistar rats using aqueous extract of Ficus vogelii.

J Trace Elem Med Biol 2019 Mar 31;52:192-198. Epub 2018 Dec 31.

Department of Anatomy, Faculty of Basic medical Sciences, University of Nigeria Enugu Campus (UNEC), Enugu State, Nigeria.

Background: Lead without nutritional value is a widely studied occupational and environmental toxicant. Leads' toxic effects on female reproduction are decreased fertility, inability to sustain pregnancy and reduced pregnancy.

Objective: This study aimed at examining the effect of oral administration of lead acetate (1. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.016DOI Listing
March 2019
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The neurotoxic impact of subchronic exposure of male rats to copper oxychloride.

J Trace Elem Med Biol 2019 Mar 31;52:186-191. Epub 2018 Dec 31.

Zoology Department, Faculty of Science, Suez University, Suez, Egypt. Electronic address:

Background: The target of this animal study was to clarify the influence of Copper oxychloride (COC) (at concentrations of 50, 100 and 200 mg/kg b.wt.) administration for ninety days on the brain tissues to evaluate its possible neurotoxicity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0946672X183063
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http://dx.doi.org/10.1016/j.jtemb.2018.12.015DOI Listing
March 2019
13 Reads